methapyrilene has been researched along with Precancerous Conditions in 4 studies
Methapyrilene: Histamine H1 antagonist with sedative action used as a hypnotic and in allergies.
methapyrilene : A member of the class of ethylenediamine derivatives that is ethylenediamine in which one of the nitrogens is substituted by two methyl groups, and the other nitrogen is substituted by a 2-pyridyl group and a (2-thienyl)methyl group.
Precancerous Conditions: Pathological conditions that tend eventually to become malignant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methapyrilene hydrochloride was administered in the feed to rats at a concentration of 1,000 ppm for periods up to 89 weeks." | 1.27 | A sequential study of methapyrilene hydrochloride-induced liver carcinogenesis in male F344 rats. ( Brennan, LM; Creasia, DA; Ohshima, M; Ward, JM, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fischer, G | 2 |
| Altmannsberger, M | 1 |
| Schauer, A | 2 |
| Katz, N | 2 |
| Bock, KW | 1 |
| Ullrich, D | 1 |
| Reznik-Schüller, HM | 1 |
| Gregg, M | 1 |
| Ohshima, M | 1 |
| Ward, JM | 1 |
| Brennan, LM | 1 |
| Creasia, DA | 1 |
4 other studies available for methapyrilene and Precancerous Conditions
| Article | Year |
|---|---|
Early stages of chemically induced liver carcinogenesis by oral administration of the antihistaminic methapyrilene hydrochloride.
Topics: Adenosine Triphosphatases; Administration, Oral; Aminopyridines; Animals; Female; gamma-Glutamyltran | 1983 |
Immunohistochemical demonstration of increased UDP-glucuronyltransferase in putative preneoplastic liver foci.
Topics: Animals; Carcinogens; Glucuronosyltransferase; Histocytochemistry; Liver; Liver Neoplasms; Methapyri | 1983 |
Sequential morphologic changes during methapyrilene-induced hepatocellular carcinogenesis in rats.
Topics: Aminopyridines; Animals; Eosinophilia; Liver; Liver Neoplasms, Experimental; Male; Methapyrilene; Mi | 1983 |
A sequential study of methapyrilene hydrochloride-induced liver carcinogenesis in male F344 rats.
Topics: Aminopyridines; Animals; Body Weight; Carcinogens; Liver; Liver Neoplasms; Liver Neoplasms, Experime | 1984 |