methapyrilene has been researched along with Liver Neoplasms in 15 studies
Methapyrilene: Histamine H1 antagonist with sedative action used as a hypnotic and in allergies.
methapyrilene : A member of the class of ethylenediamine derivatives that is ethylenediamine in which one of the nitrogens is substituted by two methyl groups, and the other nitrogen is substituted by a 2-pyridyl group and a (2-thienyl)methyl group.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The dose-response for one or more key event(s) linked to the MOA for carcinogenicity allows a point of departure (POD) to be selected from the most sensitive effect dose or no-effect dose." | 1.36 | Toxicogenomics and cancer risk assessment: a framework for key event analysis and dose-response assessment for nongenotoxic carcinogens. ( Baker, TK; Bercu, JP; Flagella, KM; Jolly, RA; Romero, P; Stevens, JL, 2010) |
| "Methapyrilene hydrochloride was administered at levels of 125 or 250 ppm in the diet to groups of male and female F344 rats." | 1.27 | Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats. ( Lijinsky, W, 1984) |
| "Methapyrilene hydrochloride was administered in the feed to rats at a concentration of 1,000 ppm for periods up to 89 weeks." | 1.27 | A sequential study of methapyrilene hydrochloride-induced liver carcinogenesis in male F344 rats. ( Brennan, LM; Creasia, DA; Ohshima, M; Ward, JM, 1984) |
| "No increase in incidence of liver neoplasms was observed after treatment with any of the four compounds, thenyldiamine, chlorothen, methafurylene, or methaphenilene, although each differed structurally from methapyrilene only in one atom or one position of substitution." | 1.27 | Carcinogenicity studies of some analogs of the carcinogen methapyrilene in F344 rats. ( Kovatch, RM; Lijinsky, W, 1986) |
| " Dosing the animals with tetradeuterium-labelled I helped identify 7 different metabolites of I in the urine, including (5-hydroxylpyridyl)-methapyrilene, which was identified by comparison with a synthetic reference standard." | 1.27 | The in vivo metabolism of methapyrilene, a hepatocarcinogen, in the rat. ( Kammerer, RC; Kloc, K; Lampe, MA; Schmitz, DA, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (80.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Omura, K | 1 |
| Uehara, T | 1 |
| Morikawa, Y | 1 |
| Hayashi, H | 1 |
| Mitsumori, K | 1 |
| Minami, K | 1 |
| Kanki, M | 1 |
| Yamada, H | 1 |
| Ono, A | 1 |
| Urushidani, T | 1 |
| Bercu, JP | 1 |
| Jolly, RA | 1 |
| Flagella, KM | 1 |
| Baker, TK | 1 |
| Romero, P | 1 |
| Stevens, JL | 1 |
| Fischer, G | 2 |
| Altmannsberger, M | 1 |
| Schauer, A | 2 |
| Katz, N | 2 |
| Bock, KW | 1 |
| Ullrich, D | 1 |
| Casciano, DA | 1 |
| Schol, HM | 1 |
| Lijinsky, W | 4 |
| Ohshima, M | 1 |
| Ward, JM | 1 |
| Brennan, LM | 2 |
| Creasia, DA | 2 |
| Furuya, K | 1 |
| Williams, GM | 1 |
| Reznik-Schüller, HM | 1 |
| Kovatch, RM | 2 |
| Thomas, BJ | 1 |
| Perera, MI | 1 |
| Katyal, SL | 1 |
| Shinozuka, H | 1 |
| Kammerer, RC | 1 |
| Schmitz, DA | 1 |
| Lampe, MA | 1 |
| Kloc, K | 1 |
| Habs, M | 1 |
| Shubik, P | 1 |
| Eisenbrand, G | 1 |
15 other studies available for methapyrilene and Liver Neoplasms
| Article | Year |
|---|---|
Detection of initiating potential of non-genotoxic carcinogens in a two-stage hepatocarcinogenesis study in rats.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; DNA D | 2014 |
Toxicogenomics and cancer risk assessment: a framework for key event analysis and dose-response assessment for nongenotoxic carcinogens.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Dose-Response Relationship, Drug; Female; Fenofibra | 2010 |
Early stages of chemically induced liver carcinogenesis by oral administration of the antihistaminic methapyrilene hydrochloride.
Topics: Adenosine Triphosphatases; Administration, Oral; Aminopyridines; Animals; Female; gamma-Glutamyltran | 1983 |
Immunohistochemical demonstration of increased UDP-glucuronyltransferase in putative preneoplastic liver foci.
Topics: Animals; Carcinogens; Glucuronosyltransferase; Histocytochemistry; Liver; Liver Neoplasms; Methapyri | 1983 |
Methapyrilene is inactive in the hepatocyte-mediated Chinese hamster ovary/hypoxanthine-guanine phosphoribosyl transferase mutational assay.
Topics: Aminopyridines; Animals; Cricetinae; Cricetulus; Female; Hypoxanthine Phosphoribosyltransferase; Liv | 1984 |
Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats.
Topics: Aminopyridines; Animals; Carcinogens; Diet; Dose-Response Relationship, Drug; Female; Liver Neoplasm | 1984 |
A sequential study of methapyrilene hydrochloride-induced liver carcinogenesis in male F344 rats.
Topics: Aminopyridines; Animals; Body Weight; Carcinogens; Liver; Liver Neoplasms; Liver Neoplasms, Experime | 1984 |
Neoplastic conversion in rat liver by the antihistamine methapyrilene demonstrated by a sequential syncarcinogenic effect with N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Aminopyridines; Animals; Diethylnitrosamine; DNA; Drug Synergism; Liver Neopl | 1984 |
The effects of methapyrilene hydrochloride on hepatocarcinogenicity and pentobarbital-induced sleeping time in rats and mice.
Topics: Aminopyridines; Animals; Enzyme Induction; Female; Liver; Liver Neoplasms; Male; Methapyrilene; Mice | 1982 |
Morphology of early changes in liver carcinogenesis induced by methapyrilene.
Topics: Aminopyridines; Animals; Female; Liver; Liver Neoplasms; Methapyrilene; Microscopy, Electron; Rats; | 1981 |
The carcinogenic effect of methapyrilene combined with nitrosodiethylamine given to rats in low doses.
Topics: Adenoma; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Drug Interactions; Female; Hepatectomy | 1992 |
Carcinogenicity studies of some analogs of the carcinogen methapyrilene in F344 rats.
Topics: Aminopyridines; Animals; Female; Histamine H1 Antagonists; Liver Neoplasms; Male; Methapyrilene; Pyr | 1986 |
Choline deficient diet enhances the initiating and promoting effects of methapyrilene hydrochloride in rat liver as assayed by the induction of gamma-glutamyltranspeptidase-positive hepatocyte foci.
Topics: Aminopyridines; Animals; Choline Deficiency; Enzyme Activation; gamma-Glutamyltransferase; Lipid Per | 1987 |
The in vivo metabolism of methapyrilene, a hepatocarcinogen, in the rat.
Topics: Aminopyridines; Animals; Deuterium; Gas Chromatography-Mass Spectrometry; Liver Neoplasms; Male; Met | 1988 |
Carcinogenicity of methapyrilene hydrochloride, mepyramine hydrochloride, thenyldiamine hydrochloride, and pyribenzamine hydrochloride in Sprague-Dawley rats.
Topics: Adenoma; Adrenal Gland Neoplasms; Aminopyridines; Animals; Dose-Response Relationship, Drug; Female; | 1986 |