methapyrilene has been researched along with Liver Diseases in 3 studies
Methapyrilene: Histamine H1 antagonist with sedative action used as a hypnotic and in allergies.
methapyrilene : A member of the class of ethylenediamine derivatives that is ethylenediamine in which one of the nitrogens is substituted by two methyl groups, and the other nitrogen is substituted by a 2-pyridyl group and a (2-thienyl)methyl group.
Liver Diseases: Pathological processes of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Administration of high doses of the histamine antagonist methapyrilene to rats causes periportal liver necrosis." | 3.73 | Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat. ( Craig, A; Holmes, E; Jackson, D; Nicholson, J; Nickson, J; Orton, T; Rowlinson, R; Sidaway, J; Tonge, R; Wilson, I, 2006) |
| " In the middle dose groups (30 mg/kg MP), no apparent changes were noted in blood biochemical data by single dosing or repeated dosing up to one week, and no obvious histopathological changes were observed except a slight hypertrophy in the hepatocytes." | 1.35 | Gene expression profiling of methapyrilene-induced hepatotoxicity in rat. ( Hirode, M; Kiyosawa, N; Miyagishima, T; Mizukawa, Y; Nagao, T; Omura, K; Ono, A; Shimizu, T; Uehara, T; Urushidani, T, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Craig, A | 1 |
| Sidaway, J | 1 |
| Holmes, E | 1 |
| Orton, T | 1 |
| Jackson, D | 1 |
| Rowlinson, R | 1 |
| Nickson, J | 1 |
| Tonge, R | 1 |
| Wilson, I | 1 |
| Nicholson, J | 1 |
| Uehara, T | 1 |
| Kiyosawa, N | 1 |
| Hirode, M | 1 |
| Omura, K | 1 |
| Shimizu, T | 1 |
| Ono, A | 1 |
| Mizukawa, Y | 1 |
| Miyagishima, T | 1 |
| Nagao, T | 1 |
| Urushidani, T | 1 |
| Graichen, ME | 1 |
| Neptun, DA | 1 |
| Dent, JG | 1 |
| Popp, JA | 1 |
| Leonard, TB | 1 |
3 other studies available for methapyrilene and Liver Diseases
| Article | Year |
|---|---|
Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Gene Expression R | 2006 |
Gene expression profiling of methapyrilene-induced hepatotoxicity in rat.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Cell Cycle; Chemical and Drug | 2008 |
Effects of methapyrilene on rat hepatic xenobiotic metabolizing enzymes and liver morphology.
Topics: Alanine Transaminase; Aminopyridines; Animals; Bile Acids and Salts; Bile Ducts; Chemical and Drug I | 1985 |