methapyrilene has been researched along with Experimental Neoplasms in 6 studies
Methapyrilene: Histamine H1 antagonist with sedative action used as a hypnotic and in allergies.
methapyrilene : A member of the class of ethylenediamine derivatives that is ethylenediamine in which one of the nitrogens is substituted by two methyl groups, and the other nitrogen is substituted by a 2-pyridyl group and a (2-thienyl)methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Triprolidine was not carcinogenic in F344 rats." | 1.29 | Triprolidine: 104-week feeding study in rats. ( Allaben, WT; Allen, R; Greenman, DL; Schieferstein, G; Sheldon, W, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fischer, G | 2 |
| Altmannsberger, M | 1 |
| Schauer, A | 2 |
| Katz, N | 2 |
| Bock, KW | 1 |
| Ullrich, D | 1 |
| Brennan, LM | 1 |
| Creasia, DA | 1 |
| Greenman, DL | 1 |
| Sheldon, W | 1 |
| Schieferstein, G | 1 |
| Allen, R | 1 |
| Allaben, WT | 1 |
| Lijinsky, W | 1 |
| Kovatch, RM | 1 |
| Thomas, BJ | 1 |
| Habs, M | 1 |
| Shubik, P | 1 |
| Eisenbrand, G | 1 |
6 other studies available for methapyrilene and Experimental Neoplasms
| Article | Year |
|---|---|
Early stages of chemically induced liver carcinogenesis by oral administration of the antihistaminic methapyrilene hydrochloride.
Topics: Adenosine Triphosphatases; Administration, Oral; Aminopyridines; Animals; Female; gamma-Glutamyltran | 1983 |
Immunohistochemical demonstration of increased UDP-glucuronyltransferase in putative preneoplastic liver foci.
Topics: Animals; Carcinogens; Glucuronosyltransferase; Histocytochemistry; Liver; Liver Neoplasms; Methapyri | 1983 |
The effects of methapyrilene hydrochloride on hepatocarcinogenicity and pentobarbital-induced sleeping time in rats and mice.
Topics: Aminopyridines; Animals; Enzyme Induction; Female; Liver; Liver Neoplasms; Male; Methapyrilene; Mice | 1982 |
Triprolidine: 104-week feeding study in rats.
Topics: Animals; Body Weight; Carcinogens; Eating; Feeding Behavior; Female; Histamine H1 Antagonists; Male; | 1995 |
The carcinogenic effect of methapyrilene combined with nitrosodiethylamine given to rats in low doses.
Topics: Adenoma; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Drug Interactions; Female; Hepatectomy | 1992 |
Carcinogenicity of methapyrilene hydrochloride, mepyramine hydrochloride, thenyldiamine hydrochloride, and pyribenzamine hydrochloride in Sprague-Dawley rats.
Topics: Adenoma; Adrenal Gland Neoplasms; Aminopyridines; Animals; Dose-Response Relationship, Drug; Female; | 1986 |