methapyrilene has been researched along with Experimental Hepatoma in 15 studies
Methapyrilene: Histamine H1 antagonist with sedative action used as a hypnotic and in allergies.
methapyrilene : A member of the class of ethylenediamine derivatives that is ethylenediamine in which one of the nitrogens is substituted by two methyl groups, and the other nitrogen is substituted by a 2-pyridyl group and a (2-thienyl)methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methapyrilene was administered ad libitum at doses of 0, 62." | 1.29 | Dose-responses in rat hepatic protein modification and expression following exposure to the rat hepatocarcinogen methapyrilene. ( Anderson, NL; Horn, DM; Richardson, FC, 1994) |
| "Bromodeoxyuridine was administered continuously using an osmotic minipump during the last week of treatment to provide an index of DNA synthesis." | 1.28 | Effects of methapyrilene on DNA synthesis in mice and rats following continuous dietary exposure. ( Copple, DM; Eacho, PI; Richardson, FC, 1992) |
| "Methapyrilene hydrochloride was administered in the feed to rats at a concentration of 1,000 ppm for periods up to 89 weeks." | 1.27 | A sequential study of methapyrilene hydrochloride-induced liver carcinogenesis in male F344 rats. ( Brennan, LM; Creasia, DA; Ohshima, M; Ward, JM, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (60.00) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Uehara, T | 1 |
| Hirode, M | 1 |
| Ono, A | 1 |
| Kiyosawa, N | 1 |
| Omura, K | 1 |
| Shimizu, T | 1 |
| Mizukawa, Y | 1 |
| Miyagishima, T | 1 |
| Nagao, T | 1 |
| Urushidani, T | 1 |
| Reznik-Schüller, HM | 1 |
| Gregg, M | 1 |
| Ohshima, M | 1 |
| Ward, JM | 1 |
| Brennan, LM | 1 |
| Creasia, DA | 1 |
| Furuya, K | 1 |
| Mori, H | 1 |
| Williams, GM | 1 |
| Lijinsky, W | 3 |
| Reuber, MD | 1 |
| Blackwell, BN | 1 |
| Richardson, FC | 3 |
| Horn, DM | 2 |
| Anderson, NL | 1 |
| Jordan, WH | 1 |
| Holloway, DC | 1 |
| Smith, WC | 1 |
| Copple, DM | 1 |
| Eacho, PI | 1 |
| Kovatch, RM | 1 |
| Thomas, BJ | 1 |
| Hernandez, L | 1 |
| Petropoulos, CJ | 1 |
| Hughes, SH | 1 |
| Glauert, HP | 1 |
| Pitot, HC | 1 |
| Fischer, G | 1 |
| Lilienblum, W | 1 |
| Ullrich, D | 1 |
| Bock, KW | 1 |
| Iype, PT | 1 |
| Bucana, CD | 1 |
| Kelley, SP | 1 |
| Kammerer, RC | 1 |
| Kloc, K | 1 |
| Lampe, MA | 1 |
| Schmitz, DA | 1 |
| Habs, M | 1 |
| Shubik, P | 1 |
| Eisenbrand, G | 1 |
15 other studies available for methapyrilene and Experimental Hepatoma
| Article | Year |
|---|---|
A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Gene Expression; Glutathione; Liver; Liver Neoplasms, E | 2008 |
Sequential morphologic changes during methapyrilene-induced hepatocellular carcinogenesis in rats.
Topics: Aminopyridines; Animals; Eosinophilia; Liver; Liver Neoplasms, Experimental; Male; Methapyrilene; Mi | 1983 |
A sequential study of methapyrilene hydrochloride-induced liver carcinogenesis in male F344 rats.
Topics: Aminopyridines; Animals; Body Weight; Carcinogens; Liver; Liver Neoplasms; Liver Neoplasms, Experime | 1984 |
An enhancing effect of the antihistaminic drug methapyrilene on rat liver carcinogenesis by previously administered N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Aminopyridines; Animals; Liver Neoplasms, Experimental; Male; Methapyrilene; | 1983 |
Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride.
Topics: Aminopyridines; Animals; Carcinogens; Drug Interactions; Female; Liver Neoplasms, Experimental; Male | 1980 |
Dose-responses in rat hepatic protein modification and expression following exposure to the rat hepatocarcinogen methapyrilene.
Topics: Animals; Carcinogens; Dose-Response Relationship, Drug; Liver; Liver Neoplasms, Experimental; Male; | 1994 |
Dose-dependent induction of GST-P+ staining foci by the rat hepatocarcinogen methapyrilene in the medium-term bioassay.
Topics: Administration, Oral; Animals; Antibodies, Monoclonal; Carcinogens; Diet; Diethylnitrosamine; Dose-R | 1996 |
Effects of methapyrilene on DNA synthesis in mice and rats following continuous dietary exposure.
Topics: Animals; Body Weight; Bromodeoxyuridine; Diet; DNA Replication; Liver; Liver Neoplasms, Experimental | 1992 |
The carcinogenic effect of methapyrilene combined with nitrosodiethylamine given to rats in low doses.
Topics: Adenoma; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Drug Interactions; Female; Hepatectomy | 1992 |
DNA methylation and oncogene expression in methapyrilene-induced rat liver tumors and in treated hepatocytes in culture.
Topics: Animals; Deoxycytidine; DNA; Gene Expression; Liver; Liver Neoplasms, Experimental; Male; Methapyril | 1991 |
Effect of the antihistamine, methapyrilene, as an initiator of hepatocarcinogenesis in female rats.
Topics: Adenosine Triphosphatases; Aminopyridines; Animals; Female; gamma-Glutamyltransferase; Glucose-6-Pho | 1989 |
Immunohistochemical differentiation of gamma-glutamyltranspeptidase in focal lesions and in zone I of rat liver after treatment with chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Female; gamma-Glutamyltransferase; Histocytochemistry; Liver; Liver | 1986 |
Carcinogenesis by nonmutagenic chemicals: early response of rat liver cells induced by methapyrilene.
Topics: Aminopyridines; Animals; Inclusion Bodies; Lipids; Liver; Liver Neoplasms, Experimental; Methapyrile | 1985 |
Oxidation of the pyridine ring: a major pathway of metabolism for the rat hepatocarcinogen, methapyrilene.
Topics: Aminopyridines; Animals; Cricetinae; Guinea Pigs; Liver Neoplasms, Experimental; Male; Methapyrilene | 1987 |
Carcinogenicity of methapyrilene hydrochloride, mepyramine hydrochloride, thenyldiamine hydrochloride, and pyribenzamine hydrochloride in Sprague-Dawley rats.
Topics: Adenoma; Adrenal Gland Neoplasms; Aminopyridines; Animals; Dose-Response Relationship, Drug; Female; | 1986 |