methapyrilene has been researched along with Carcinoma, Hepatocellular in 2 studies
Methapyrilene: Histamine H1 antagonist with sedative action used as a hypnotic and in allergies.
methapyrilene : A member of the class of ethylenediamine derivatives that is ethylenediamine in which one of the nitrogens is substituted by two methyl groups, and the other nitrogen is substituted by a 2-pyridyl group and a (2-thienyl)methyl group.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The dose-response for one or more key event(s) linked to the MOA for carcinogenicity allows a point of departure (POD) to be selected from the most sensitive effect dose or no-effect dose." | 1.36 | Toxicogenomics and cancer risk assessment: a framework for key event analysis and dose-response assessment for nongenotoxic carcinogens. ( Baker, TK; Bercu, JP; Flagella, KM; Jolly, RA; Romero, P; Stevens, JL, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Omura, K | 1 |
| Uehara, T | 1 |
| Morikawa, Y | 1 |
| Hayashi, H | 1 |
| Mitsumori, K | 1 |
| Minami, K | 1 |
| Kanki, M | 1 |
| Yamada, H | 1 |
| Ono, A | 1 |
| Urushidani, T | 1 |
| Bercu, JP | 1 |
| Jolly, RA | 1 |
| Flagella, KM | 1 |
| Baker, TK | 1 |
| Romero, P | 1 |
| Stevens, JL | 1 |
2 other studies available for methapyrilene and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Detection of initiating potential of non-genotoxic carcinogens in a two-stage hepatocarcinogenesis study in rats.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; DNA D | 2014 |
Toxicogenomics and cancer risk assessment: a framework for key event analysis and dose-response assessment for nongenotoxic carcinogens.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Dose-Response Relationship, Drug; Female; Fenofibra | 2010 |