methapyrilene has been researched along with Body Weight in 6 studies
Methapyrilene: Histamine H1 antagonist with sedative action used as a hypnotic and in allergies.
methapyrilene : A member of the class of ethylenediamine derivatives that is ethylenediamine in which one of the nitrogens is substituted by two methyl groups, and the other nitrogen is substituted by a 2-pyridyl group and a (2-thienyl)methyl group.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methapyrilene treatment alone specifically decreased microsomal enzyme activity markers for CYP2C11, CYP3A, and CYP2A and pretreatment with all the hepatic enzyme-inducing agents specifically prevented the loss of CYP2C11." | 1.30 | Effects of induction and inhibition of cytochromes P450 on the hepatotoxicity of methapyrilene. ( Cottrell, S; Powell, CJ; Ratra, GS, 1998) |
| "Methapyrilene (MPH) was a widely used antihistamine until it was found to produce hepatocellular carcinoma and cholangiocarcinoma in Fischer 344 rats." | 1.29 | The hepatocarcinogen methapyrilene but not the analog pyrilamine induces sustained hepatocellular replication and protein alterations in F344 rats in a 13-week feed study. ( Anderson, NL; Cunningham, ML; Pippin, LL; Wenk, ML, 1995) |
| "Triprolidine was not carcinogenic in F344 rats." | 1.29 | Triprolidine: 104-week feeding study in rats. ( Allaben, WT; Allen, R; Greenman, DL; Schieferstein, G; Sheldon, W, 1995) |
| "Bromodeoxyuridine was administered continuously using an osmotic minipump during the last week of treatment to provide an index of DNA synthesis." | 1.28 | Effects of methapyrilene on DNA synthesis in mice and rats following continuous dietary exposure. ( Copple, DM; Eacho, PI; Richardson, FC, 1992) |
| "Methapyrilene hydrochloride was administered in the feed to rats at a concentration of 1,000 ppm for periods up to 89 weeks." | 1.27 | A sequential study of methapyrilene hydrochloride-induced liver carcinogenesis in male F344 rats. ( Brennan, LM; Creasia, DA; Ohshima, M; Ward, JM, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mally, A | 1 |
| Chipman, JK | 1 |
| Ohshima, M | 1 |
| Ward, JM | 1 |
| Brennan, LM | 1 |
| Creasia, DA | 1 |
| Cunningham, ML | 1 |
| Pippin, LL | 1 |
| Anderson, NL | 1 |
| Wenk, ML | 1 |
| Greenman, DL | 1 |
| Sheldon, W | 1 |
| Schieferstein, G | 1 |
| Allen, R | 1 |
| Allaben, WT | 1 |
| Ratra, GS | 1 |
| Cottrell, S | 1 |
| Powell, CJ | 1 |
| Richardson, FC | 1 |
| Copple, DM | 1 |
| Eacho, PI | 1 |
6 other studies available for methapyrilene and Body Weight
| Article | Year |
|---|---|
Non-genotoxic carcinogens: early effects on gap junctions, cell proliferation and apoptosis in the rat.
Topics: Animals; Apoptosis; Body Weight; Carcinogens; Cell Division; Connexin 26; Connexins; Dose-Response R | 2002 |
A sequential study of methapyrilene hydrochloride-induced liver carcinogenesis in male F344 rats.
Topics: Aminopyridines; Animals; Body Weight; Carcinogens; Liver; Liver Neoplasms; Liver Neoplasms, Experime | 1984 |
The hepatocarcinogen methapyrilene but not the analog pyrilamine induces sustained hepatocellular replication and protein alterations in F344 rats in a 13-week feed study.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Cell Division; Dose-Response Relationship, | 1995 |
Triprolidine: 104-week feeding study in rats.
Topics: Animals; Body Weight; Carcinogens; Eating; Feeding Behavior; Female; Histamine H1 Antagonists; Male; | 1995 |
Effects of induction and inhibition of cytochromes P450 on the hepatotoxicity of methapyrilene.
Topics: Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cy | 1998 |
Effects of methapyrilene on DNA synthesis in mice and rats following continuous dietary exposure.
Topics: Animals; Body Weight; Bromodeoxyuridine; Diet; DNA Replication; Liver; Liver Neoplasms, Experimental | 1992 |