methapyrilene has been researched along with Acute Liver Injury, Drug-Induced in 16 studies
Methapyrilene: Histamine H1 antagonist with sedative action used as a hypnotic and in allergies.
methapyrilene : A member of the class of ethylenediamine derivatives that is ethylenediamine in which one of the nitrogens is substituted by two methyl groups, and the other nitrogen is substituted by a 2-pyridyl group and a (2-thienyl)methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methapyrilene, [N,N-dimethyl-N'-pyridyl-N'(2-thienylmethyl)-1,2-ethanediamine] (MP) was withdrawn from, clinical use due to reported periportal hepatic necrosis and hepatocarcinogenicity in the rat, via S-oxidation of the thiophene group." | 7.75 | Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis. ( Antoine, DJ; Benson, CA; Foster, J; Graham, EE; Hirst, CM; Kenna, JG; Mercer, AE; Park, BK; Regan, SL; Williams, DP, 2009) |
| "Methapyrilene, [N,N-dimethyl-N'-pyridyl-N'(2-thienylmethyl)-1,2-ethanediamine] (MP) was withdrawn from, clinical use due to reported periportal hepatic necrosis and hepatocarcinogenicity in the rat, via S-oxidation of the thiophene group." | 3.75 | Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis. ( Antoine, DJ; Benson, CA; Foster, J; Graham, EE; Hirst, CM; Kenna, JG; Mercer, AE; Park, BK; Regan, SL; Williams, DP, 2009) |
| "Administration of high doses of the histamine antagonist methapyrilene to rats causes periportal liver necrosis." | 3.73 | Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat. ( Craig, A; Holmes, E; Jackson, D; Nicholson, J; Nickson, J; Orton, T; Rowlinson, R; Sidaway, J; Tonge, R; Wilson, I, 2006) |
| " Methapyrilene, a known hepatotoxin was dosed daily over 14-days at doses of 30 and 80mg/kg, followed by a recovery phase of 10days." | 1.46 | Quantitative targeted bile acid profiling as new markers for DILI in a model of methapyrilene-induced liver injury in rats. ( Ellinger-Ziegelbauer, H; Ernst, R; Herrmann, A; Keck, M; Mally, A; Pavkovic, M; Riefke, B; Slopianka, M, 2017) |
| " The method was successfully applied to the determination of OA in samples obtained following the chronic administration of the rat hepatotoxin methapyrilene, where plasma OA concentrations were observed to show a weak negative correlation with those of established liver injury biomarkers such as aspartate aminotransferase (AST)." | 1.37 | HPLC-MS/MS methods for the quantitative analysis of ophthalmic acid in rodent plasma and hepatic cell line culture medium. ( Geenen, S; Kenna, JG; Kolaja, KL; Michopoulos, F; Westerhoff, HV; Wilson, I, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| " In the middle dose groups (30 mg/kg MP), no apparent changes were noted in blood biochemical data by single dosing or repeated dosing up to one week, and no obvious histopathological changes were observed except a slight hypertrophy in the hepatocytes." | 1.35 | Gene expression profiling of methapyrilene-induced hepatotoxicity in rat. ( Hirode, M; Kiyosawa, N; Miyagishima, T; Mizukawa, Y; Nagao, T; Omura, K; Ono, A; Shimizu, T; Uehara, T; Urushidani, T, 2008) |
| "Methapyrilene treatment alone specifically decreased microsomal enzyme activity markers for CYP2C11, CYP3A, and CYP2A and pretreatment with all the hepatic enzyme-inducing agents specifically prevented the loss of CYP2C11." | 1.30 | Effects of induction and inhibition of cytochromes P450 on the hepatotoxicity of methapyrilene. ( Cottrell, S; Powell, CJ; Ratra, GS, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 9 (56.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Dawson, S | 1 |
| Stahl, S | 2 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 5 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Slopianka, M | 1 |
| Herrmann, A | 1 |
| Pavkovic, M | 1 |
| Ellinger-Ziegelbauer, H | 1 |
| Ernst, R | 1 |
| Mally, A | 1 |
| Keck, M | 1 |
| Riefke, B | 1 |
| Leitch, AC | 1 |
| Probert, PME | 1 |
| Shayman, JA | 1 |
| Meyer, SK | 1 |
| Kass, GEN | 1 |
| Wright, MC | 1 |
| Braeuning, A | 1 |
| Oberemm, A | 1 |
| Heise, T | 1 |
| Gundert-Remy, U | 1 |
| Hengstler, JG | 1 |
| Lampen, A | 1 |
| Mercer, AE | 1 |
| Regan, SL | 1 |
| Hirst, CM | 2 |
| Graham, EE | 2 |
| Antoine, DJ | 1 |
| Benson, CA | 1 |
| Williams, DP | 2 |
| Foster, J | 1 |
| Park, BK | 2 |
| Geenen, S | 1 |
| Michopoulos, F | 1 |
| Kolaja, KL | 1 |
| Westerhoff, HV | 1 |
| Wilson, I | 2 |
| O'Brien, PJ | 1 |
| Slaughter, MR | 1 |
| Polley, SR | 1 |
| Kramer, K | 1 |
| Craig, A | 1 |
| Sidaway, J | 1 |
| Holmes, E | 1 |
| Orton, T | 1 |
| Jackson, D | 1 |
| Rowlinson, R | 1 |
| Nickson, J | 1 |
| Tonge, R | 1 |
| Nicholson, J | 1 |
| Uehara, T | 1 |
| Kiyosawa, N | 1 |
| Hirode, M | 1 |
| Omura, K | 1 |
| Shimizu, T | 1 |
| Ono, A | 1 |
| Mizukawa, Y | 1 |
| Miyagishima, T | 1 |
| Nagao, T | 1 |
| Urushidani, T | 1 |
| Walsh, RJ | 1 |
| Maggs, JL | 1 |
| Martin, S | 1 |
| Wild, MJ | 1 |
| Wilson, ID | 1 |
| Harding, JR | 1 |
| Peter, RM | 1 |
| Ratra, GS | 1 |
| Cottrell, S | 1 |
| Powell, CJ | 1 |
| Graichen, ME | 1 |
| Neptun, DA | 1 |
| Dent, JG | 1 |
| Popp, JA | 1 |
| Leonard, TB | 1 |
16 other studies available for methapyrilene and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Quantitative targeted bile acid profiling as new markers for DILI in a model of methapyrilene-induced liver injury in rats.
Topics: Animals; Bile Acids and Salts; Biomarkers; Chemical and Drug Induced Liver Injury; Chromatography, L | 2017 |
B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals.
Topics: Animals; Benzoates; Benzylamines; Cell Line; Chemical and Drug Induced Liver Injury; Dose-Response R | 2017 |
In vitro proteomic analysis of methapyrilene toxicity in rat hepatocytes reveals effects on intermediary metabolism.
Topics: Animals; Cell Culture Techniques; Chemical and Drug Induced Liver Injury; Computational Biology; Gen | 2019 |
Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis.
Topics: Animals; Apoptosis; Blotting, Western; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liv | 2009 |
HPLC-MS/MS methods for the quantitative analysis of ophthalmic acid in rodent plasma and hepatic cell line culture medium.
Topics: Animals; Biomarkers; Cell Line; Chemical and Drug Induced Liver Injury; Chromatography, High Pressur | 2011 |
Advantages of glutamate dehydrogenase as a blood biomarker of acute hepatic injury in rats.
Topics: Acute Disease; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Biomarkers; Chemical and | 2002 |
Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Gene Expression R | 2006 |
Gene expression profiling of methapyrilene-induced hepatotoxicity in rat.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Cell Cycle; Chemical and Drug | 2008 |
Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore.
Topics: Animals; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromatography, Hig | 2008 |
Effects of induction and inhibition of cytochromes P450 on the hepatotoxicity of methapyrilene.
Topics: Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cy | 1998 |
Effects of methapyrilene on rat hepatic xenobiotic metabolizing enzymes and liver morphology.
Topics: Alanine Transaminase; Aminopyridines; Animals; Bile Acids and Salts; Bile Ducts; Chemical and Drug I | 1985 |