methanol has been researched along with Hepatocellular Carcinoma in 41 studies
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.
primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.
methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Apigenin has 92 targets out of 627 total targets related to HCC, while there was13 pathways in the target-pathway network." | 5.72 | Network pharmacology-based study on apigenin present in the methanolic fraction of leaves extract of Cestrum nocturnum L. to uncover mechanism of action on hepatocellular carcinoma. ( Kumar, P; Mishra, SK; Singh, AK; Tiwari, KN; Verma, P, 2022) |
| "speciosus on the growth of human hepatocellular carcinoma (HepG2) cells and understand possible mechanisms of its action." | 5.40 | Apoptotic and inhibitory effects on cell proliferation of hepatocellular carcinoma HepG2 cells by methanol leaf extract of Costus speciosus. ( Hettihewa, M; Nair, SV; Rupasinghe, HP, 2014) |
| " Together, these findings indicate that OSU-A9 is a potent, orally bioavailable inhibitor of the Akt-NF-kappaB signaling network with a broad spectrum of antitumor activity that includes targets regulating multiple aspects of HCC pathogenesis and progression." | 5.35 | Targeting of the Akt-nuclear factor-kappa B signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma. ( Chen, CS; Kulp, SK; Omar, HA; Patel, T; Sargeant, AM; Wang, D; Weng, JR, 2009) |
| " Hepatocellular Carcinoma (HCC) was induced in the liver of male Sprague Dawley (SD) rats by treating with diethylnitrosamine (DEN)." | 3.85 | In vitro, In silico and In vivo Antitumor Activity of Crude Methanolic Extract of Tetilla dactyloidea (Carter, 1869) on DEN Induced HCC in a Rat Model. ( Antony Joseph, SR; Krishnan, GS; Rajagopal, V; Savarimuthu, I; Sebastian, D; Selvaraj, KRN; Thobias, AF, 2017) |
| " communis methanol extract (AM) and its dichloromethane fraction (AD) in two human hepatocellular carcinoma (HCC) cell lines, HepG2 and PLC/PRF/5." | 3.81 | Artocarpus communis Induces Autophagic Instead of Apoptotic Cell Death in Human Hepatocellular Carcinoma Cells. ( Lee, CW; Lin, CC; Lin, LT; Tzeng, CW; Tzeng, WS; Yen, FL; Yen, MH, 2015) |
| "Apigenin has 92 targets out of 627 total targets related to HCC, while there was13 pathways in the target-pathway network." | 1.72 | Network pharmacology-based study on apigenin present in the methanolic fraction of leaves extract of Cestrum nocturnum L. to uncover mechanism of action on hepatocellular carcinoma. ( Kumar, P; Mishra, SK; Singh, AK; Tiwari, KN; Verma, P, 2022) |
| "Hepatocellular carcinoma is the most frequent and deadliest cancers worldwide." | 1.51 | Cytotoxic potentials of S. cumini methanolic seed kernel extract in human hepatoma HepG2 cells. ( Devaraj, E; Solai Prakash, AK, 2019) |
| "speciosus on the growth of human hepatocellular carcinoma (HepG2) cells and understand possible mechanisms of its action." | 1.40 | Apoptotic and inhibitory effects on cell proliferation of hepatocellular carcinoma HepG2 cells by methanol leaf extract of Costus speciosus. ( Hettihewa, M; Nair, SV; Rupasinghe, HP, 2014) |
| " Together, these findings indicate that OSU-A9 is a potent, orally bioavailable inhibitor of the Akt-NF-kappaB signaling network with a broad spectrum of antitumor activity that includes targets regulating multiple aspects of HCC pathogenesis and progression." | 1.35 | Targeting of the Akt-nuclear factor-kappa B signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma. ( Chen, CS; Kulp, SK; Omar, HA; Patel, T; Sargeant, AM; Wang, D; Weng, JR, 2009) |
| "Unknown and uncontrolled toxic materials in the environment of experimental animals endanger the reliability of research results." | 1.30 | Cytotoxicity and biotransformation inducing activity of rodent beddings: a global survey using the Hepa-1 assay. ( Hänninen, OO; Pelkonen, KH, 1997) |
| "Among five human hepatoma cell lines (Hep G2, HLE, HuH-6, HuH-7, and PLC/PRF/5), only HLE cells showed enhanced colony formation due to methanol." | 1.29 | Methanol stimulates the colony-formation rate in a human hepatoma cell line (HLE). ( Gu, YC; Kitajiri, S; Namba, M; Ohomori, M; Okada, S, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (36.59) | 18.7374 |
| 1990's | 4 (9.76) | 18.2507 |
| 2000's | 7 (17.07) | 29.6817 |
| 2010's | 13 (31.71) | 24.3611 |
| 2020's | 2 (4.88) | 2.80 |
| Authors | Studies |
|---|---|
| Kumar, P | 1 |
| Singh, AK | 1 |
| Verma, P | 1 |
| Tiwari, KN | 1 |
| Mishra, SK | 1 |
| Şebin, M | 1 |
| Yılmaz, N | 1 |
| Aydın, A | 1 |
| Solai Prakash, AK | 1 |
| Devaraj, E | 1 |
| Krishnan, GS | 1 |
| Rajagopal, V | 1 |
| Antony Joseph, SR | 1 |
| Sebastian, D | 1 |
| Savarimuthu, I | 1 |
| Selvaraj, KRN | 1 |
| Thobias, AF | 1 |
| Ju, A | 1 |
| Cho, YC | 1 |
| Kim, BR | 1 |
| Lee, S | 1 |
| Le, HTT | 1 |
| Vuong, HL | 1 |
| Cho, S | 1 |
| Ahmad, K | 1 |
| Hafeez, ZB | 1 |
| Bhat, AR | 1 |
| Rizvi, MA | 1 |
| Thakur, SC | 1 |
| Azam, A | 1 |
| Athar, F | 1 |
| Omar, HA | 2 |
| Arafa, el-SA | 1 |
| Maghrabi, IA | 1 |
| Weng, JR | 2 |
| Nair, SV | 1 |
| Hettihewa, M | 1 |
| Rupasinghe, HP | 1 |
| Tzeng, CW | 1 |
| Tzeng, WS | 1 |
| Lin, LT | 1 |
| Lee, CW | 1 |
| Yen, MH | 1 |
| Yen, FL | 1 |
| Lin, CC | 1 |
| Armentano, MF | 1 |
| Bisaccia, F | 1 |
| Miglionico, R | 1 |
| Russo, D | 1 |
| Nolfi, N | 1 |
| Carmosino, M | 1 |
| Andrade, PB | 1 |
| Valentão, P | 1 |
| Diop, MS | 1 |
| Milella, L | 1 |
| Reddy, BS | 1 |
| Reddy, RK | 1 |
| Reddy, BP | 1 |
| Ramakrishna, S | 1 |
| Diwan, PV | 1 |
| Sargeant, AM | 1 |
| Wang, D | 1 |
| Kulp, SK | 1 |
| Patel, T | 1 |
| Chen, CS | 1 |
| Stevens, AP | 1 |
| Dettmer, K | 1 |
| Kirovski, G | 1 |
| Samejima, K | 1 |
| Hellerbrand, C | 1 |
| Bosserhoff, AK | 1 |
| Oefner, PJ | 1 |
| Hempel, JM | 1 |
| Greif-Higer, G | 1 |
| Kaufmann, T | 1 |
| Beutel, ME | 1 |
| Zedda, G | 1 |
| Simbula, G | 1 |
| Begala, M | 1 |
| Pibiri, M | 1 |
| Floris, C | 1 |
| Casu, M | 1 |
| Casu, L | 1 |
| Tocco, G | 1 |
| Abdel-Hamid, NM | 1 |
| Abdel-Ghany, MI | 1 |
| Nazmy, MH | 1 |
| Amgad, SW | 1 |
| Norikura, T | 1 |
| Kojima-Yuasa, A | 1 |
| Shimizu, M | 1 |
| Huang, X | 1 |
| Xu, S | 1 |
| Kametani, S | 1 |
| Rho, SN | 1 |
| Kennedy, DO | 1 |
| Matsui-Yuasa, I | 1 |
| Nakajima, T | 1 |
| Kagawa, K | 1 |
| Ueda, K | 1 |
| Ohkawara, T | 1 |
| Kimura, H | 1 |
| Kakusui, M | 1 |
| Deguchi, T | 1 |
| Okanoue, T | 1 |
| Kashima, K | 1 |
| Ashihara, T | 1 |
| Gu, YC | 1 |
| Okada, S | 1 |
| Ohomori, M | 1 |
| Kitajiri, S | 1 |
| Namba, M | 1 |
| Wilms, H | 1 |
| Hartmann, D | 1 |
| Sievers, J | 1 |
| Hopper, DG | 1 |
| Pimm, MV | 1 |
| Baldwin, RW | 1 |
| Wainberg, MA | 1 |
| Deutsch, V | 1 |
| Weiss, DW | 3 |
| Kuzela, S | 1 |
| Krempaský, V | 1 |
| Kolarov, J | 1 |
| Ujházy, V | 1 |
| Pancake, SJ | 1 |
| Hollingdale, MR | 1 |
| Saito, T | 1 |
| Hakomori, SI | 1 |
| Fukunishi, R | 1 |
| Watanabe, K | 1 |
| Sieber, SM | 1 |
| Whang-Peng, J | 1 |
| Johns, DG | 1 |
| Adamson, RH | 1 |
| Haese, WH | 1 |
| Smith, DL | 1 |
| Bueding, E | 1 |
| Minden, P | 1 |
| Wainberg, M | 1 |
| Dastur, DK | 1 |
| Palekar, RS | 1 |
| Chen, TH | 1 |
| Liau, BC | 1 |
| Wang, SY | 1 |
| Jong, TT | 1 |
| Freise, C | 1 |
| Ruehl, M | 1 |
| Erben, U | 1 |
| Neumann, U | 1 |
| Seehofer, D | 1 |
| Kim, KY | 1 |
| Trowitzsch-Kienast, W | 1 |
| Stroh, T | 1 |
| Zeitz, M | 1 |
| Somasundaram, R | 1 |
| Su, BN | 1 |
| Park, EJ | 1 |
| Mbwambo, ZH | 1 |
| Santarsiero, BD | 1 |
| Mesecar, AD | 1 |
| Fong, HH | 1 |
| Pezzuto, JM | 1 |
| Kinghorn, AD | 1 |
| Asari, M | 1 |
| Takatsuki, H | 1 |
| Yamazaki, M | 1 |
| Azuma, T | 1 |
| Takigami, H | 1 |
| Sakai, S | 1 |
| Li, J | 1 |
| Zhang, YJ | 1 |
| Jin, BF | 1 |
| Su, XJ | 1 |
| Tao, YW | 1 |
| She, ZG | 1 |
| Lin, YC | 1 |
| Pelkonen, KH | 1 |
| Hänninen, OO | 1 |
| Heston, WE | 1 |
| Sabine, JR | 2 |
| Vlahakis, G | 1 |
| Horton, BJ | 1 |
| Wicks, MB | 1 |
1 review available for methanol and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Immunological intervention in neoplasia.
Topics: Adjuvants, Immunologic; Animals; Antibodies, Neoplasm; Antigen-Antibody Complex; Antigens, Bacterial | 1974 |
1 trial available for methanol and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Can methanolic extract of Nigella sativa seed affect glyco-regulatory enzymes in experimental hepatocellular carcinoma?
Topics: Animals; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Carbon Tetrachloride; Carcinoma, Hepa | 2013 |
39 other studies available for methanol and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Network pharmacology-based study on apigenin present in the methanolic fraction of leaves extract of Cestrum nocturnum L. to uncover mechanism of action on hepatocellular carcinoma.
Topics: Apigenin; Carcinoma, Hepatocellular; Cestrum; Humans; Liver Neoplasms; Methanol; Network Pharmacolog | 2022 |
Some Wild Mushrooms with High Antioxidant Capacity Exhibit Potent Anticancer Activity on Cancer Cells using the Apoptotic and Antimigration Cell Death Mechanisms.
Topics: Agaricales; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; DNA; Female; Hexanes; Humans; Methan | 2023 |
Cytotoxic potentials of S. cumini methanolic seed kernel extract in human hepatoma HepG2 cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; Down-Regulation; Hep G2 Cells; Hepatocyte Nuclear Factor 1-alp | 2019 |
In vitro, In silico and In vivo Antitumor Activity of Crude Methanolic Extract of Tetilla dactyloidea (Carter, 1869) on DEN Induced HCC in a Rat Model.
Topics: Animals; Antineoplastic Agents; Antioxidants; Biomarkers, Tumor; Body Weight; Carcinoma, Hepatocellu | 2017 |
Anticancer effects of methanol extract of Myrmecodia platytyrea Becc. leaves against human hepatocellular carcinoma cells via inhibition of ERK and STAT3 signaling pathways.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Extracellular Signal-Regulated MAP Kinas | 2018 |
Antioxidant and apoptotic effects of Callistemon lanceolatus leaves and their compounds against human cancer cells.
Topics: Acetates; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Breast Neoplasms; Carcinoma, H | 2018 |
Sensitization of hepatocellular carcinoma cells to Apo2L/TRAIL by a novel Akt/NF-κB signalling inhibitor.
Topics: Carcinoma, Hepatocellular; Caspase 3; Caspase 8; Cell Line, Tumor; Humans; Indoles; Liver Neoplasms; | 2014 |
Apoptotic and inhibitory effects on cell proliferation of hepatocellular carcinoma HepG2 cells by methanol leaf extract of Costus speciosus.
Topics: Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Cell Cycle; Cell Proliferation; Cell Shape; Costus; | 2014 |
Artocarpus communis Induces Autophagic Instead of Apoptotic Cell Death in Human Hepatocellular Carcinoma Cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Artocarpus; Autophagy; Carcinoma, Hepatocellular; Cell | 2015 |
Antioxidant and proapoptotic activities of Sclerocarya birrea [(A. Rich.) Hochst.] methanolic root extract on the hepatocellular carcinoma cell line HepG2.
Topics: Anacardiaceae; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Hep G2 Cells; Humans; Liver Neopl | 2015 |
Potential in vitro antioxidant and protective effects of Soymida febrifuga on ethanol induced oxidative damage in HepG2 cells.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Cell Line, Tumor; Etha | 2008 |
Targeting of the Akt-nuclear factor-kappa B signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Disease Models, Animal; Drug Delivery Systems; | 2009 |
Quantification of intermediates of the methionine and polyamine metabolism by liquid chromatography-tandem mass spectrometry in cultured tumor cells and liver biopsies.
Topics: Calibration; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromatography, Liquid; Humans; Liver Neop | 2010 |
Detection of alcohol consumption in patients with alcoholic liver cirrhosis during the evaluation process for liver transplantation.
Topics: Alcohol Drinking; Alcoholism; Carcinoma, Hepatocellular; Ethanol; Female; Hepatitis B; Hepatitis C; | 2012 |
Mild synthetic approach to novel indole-1-carbinols and preliminary evaluation of their cytotoxicity in hepatocarcinoma cells.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Indoles; Liver Neopla | 2012 |
Mechanism of growth inhibitory effect of Blumea balsamifera extract in hepatocellular carcinoma.
Topics: Animals; Asteraceae; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Ce | 2008 |
Evaluation of hepatic proliferative activity in chronic liver diseases and hepatocellular carcinomas by proliferating cell nuclear antigen (PCNA) immunohistochemical staining of methanol-fixed tissues.
Topics: Analysis of Variance; Carcinoma, Hepatocellular; Cell Division; Chronic Disease; Fixatives; Formalde | 1994 |
Methanol stimulates the colony-formation rate in a human hepatoma cell line (HLE).
Topics: Carcinoma, Hepatocellular; Colony-Forming Units Assay; Humans; Liver Neoplasms; Methanol; Tumor Cell | 1993 |
Ramification of microglia, monocytes and macrophages in vitro: influences of various epithelial and mesenchymal cells and their conditioned media.
Topics: Animals; Astrocytes; Carcinoma, Hepatocellular; Cell Culture Techniques; Cell Size; Culture Media, C | 1997 |
Methanol extraction residue of BCG in the treatment of transplanted rat tumours.
Topics: Animals; BCG Vaccine; Carcinoma, Hepatocellular; Female; Liver Neoplasms; Male; Mammary Neoplasms, E | 1975 |
Stimulation of anti-tumour immunity in guinea-pigs by methanol extraction residue of BCG.
Topics: Animals; BCG Vaccine; Carcinoma, Hepatocellular; Cell Migration Inhibition; Guinea Pigs; Hypersensit | 1976 |
Formation, size, and solubility in chloroform/methanol of products of protein synthesis in isolated mitochondria of rat liver and Zajdela hepatoma.
Topics: Animals; Carcinoma, Hepatocellular; Chloramphenicol; Chloroform; Female; Hydrogen-Ion Concentration; | 1975 |
Plasmodium berghei: reaction of sporozoites with chemically and enzymatically modified hepatoma cells.
Topics: Carcinoma, Hepatocellular; Cells, Cultured; Chymotrypsin; Formaldehyde; Galactose Oxidase; Glutaral; | 1986 |
Quantitative isolation of total glycosphingolipids from animal cells.
Topics: Acetates; Acetone; Anhydrides; Animals; Carcinoma, Hepatocellular; Cell Biology; Cerebrosides; Chlor | 1971 |
[Natural carcinogens: hepatic disorders in the rat caused by cycasin, with special reference to the induction of hepatic tumors].
Topics: Animals; Azo Compounds; Carcinogens; Carcinoma, Hepatocellular; Female; Glucose; Glycosides; Hemangi | 1972 |
Effects of hycanthone on rapidly proliferating cells.
Topics: Aldehyde Oxidoreductases; Animals; Anthelmintics; Antineoplastic Agents; Carcinoma 256, Walker; Carc | 1973 |
Hycanthone-induced hepatic changes in mice infected with Schistosoma mansoni.
Topics: Animals; Anthelmintics; Bile; Carcinoma, Hepatocellular; Ethylenediamines; Female; Hyperplasia; Live | 1973 |
Protection against guinea pig hepatomas by pretreatment with subcelluar fractions of Mycobacterium bovis (BCG).
Topics: Animals; BCG Vaccine; Carcinoma, Hepatocellular; Cell Fractionation; Cell Line; Female; Guinea Pigs; | 1974 |
The experimental pathology of cycad toxicity with special reference to oncogenic effects.
Topics: Adenoma; Animals; Animals, Newborn; Azo Compounds; Carcinogens; Carcinoma, Hepatocellular; Glycoside | 1974 |
Isolation and cytotoxicity of the lignanoids from Chamaecyparis formosensis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Artemia; Benzodioxoles; Benzofurans; Carcinoma, Hepatoce | 2008 |
A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Ce | 2011 |
New chemical constituents of Euphorbia quinquecostata and absolute configuration assignment by a convenient Mosher ester procedure carried out in NMR tubes.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Crystallography, X-Ray; Diterpe | 2002 |
Waste wood recycling as animal bedding and development of bio-monitoring tool using the CALUX assay.
Topics: Animals; Benzofurans; Biological Assay; Carcinoma, Hepatocellular; Conservation of Natural Resources | 2004 |
1H and 13C NMR assignments for two lignans from the heartwood of Streblus asper.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Li | 2008 |
Cytotoxicity and biotransformation inducing activity of rodent beddings: a global survey using the Hepa-1 assay.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carcinoma, Hepatocellular; Cytochrome P-4 | 1997 |
Testing for possible effects of cedar wood shavings and diet on occurrence of mammary gland tumors and hepatomas in C3H-A-vy and C3H-Avy-fB mice.
Topics: Animals; Carcinoma, Hepatocellular; Diet; Female; Housing, Animal; Liver Neoplasms; Male; Mammary Ne | 1975 |
Exposure to an environment containing the aromatic red cedar, Juniperus virginiana: procarcinogenic, enzyme-inducing and insecticidal effects.
Topics: Animals; Carcinoma, Hepatocellular; Cockroaches; Environment; Enzyme Induction; Insecta; Liver Neopl | 1975 |
Possible carcinogenic effects of cedar shavings in bedding of C3H-Avy fB mice.
Topics: Age Factors; Animals; Carcinogens, Environmental; Carcinoma, Hepatocellular; Female; Liver Neoplasms | 1977 |
Spontaneous tumors in C3H-A vy and C3H-A vy fB mice: high incidence in the United States and low incidence in Australia.
Topics: Age Factors; Animals; Animals, Laboratory; Australia; Carcinoma, Hepatocellular; Environmental Expos | 1973 |