methanol has been researched along with Folic Acid Deficiency in 21 studies
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.
primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.
methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.
Folic Acid Deficiency: A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic ethanol use can lead to folic acid deficiency in humans." | 3.66 | Relationship of alcohol metabolism to folate deficiency produced by ethanol in the rat. ( Collins, TD; McMartin, KE, 1983) |
| " Monkeys were then reexposed to the highest exposure concentration, 900 ppm 14C-methanol, for a similar 2-hour period, and again the pharmacokinetic data described above were obtained." | 1.30 | Pharmacokinetics of methanol and formate in female cynomolgus monkeys exposed to methanol vapors. ( Bond, JA; Dorman, DC; Everitt, JI; Janszen, DB; Medinsky, MA; Moss, OR, 1997) |
| "Formaldehyde was not detected in blood or vitreous humor with or without DSF treatment, suggesting that formate is the toxic metabolite in methanol-induced retinal toxicity." | 1.29 | Role of retinal metabolism in methanol-induced retinal toxicity. ( Garner, CD; Lee, EW; Louis-Ferdinand, RT; Terzo, TS, 1995) |
| "Methanol is an ocular toxicant which causes visual dysfunction often leading to blindness after acute exposure." | 1.29 | Müller cell involvement in methanol-induced retinal toxicity. ( Garner, CD; Lee, EW; Louis-Ferdinand, RT, 1995) |
| "Methanol was administered to rats by either the oral or inhalation route." | 1.29 | A rat model manifesting methanol-induced visual dysfunction suitable for both acute and long-term exposure studies. ( Garner, CD; Lee, EW; Terzo, TS, 1994) |
| "We attempted to develop a rodent model that exhibits characteristics of human methanol toxicities such as acidosis and visual dysfunction, which are correlated with an accumulation of formate, a toxic metabolite of methanol." | 1.29 | Animal model for the study of methanol toxicity: comparison of folate-reduced rat responses with published monkey data. ( Garner, CD; Lee, EW; Terzo, TS, 1994) |
| "Fetal body weights were lowest in the low folic acid groups and significantly lower in the methanol groups relative to vehicle-treated animals." | 1.29 | Influence of maternal folate status on the developmental toxicity of methanol in the CD-1 mouse. ( Connelly, LE; Fu, SS; Keen, CL; Rogers, JM; Sakanashi, TM, 1996) |
| "Methanol treated (4 g/kg) Csb-FAD mice excreted 30." | 1.26 | Acute toxicity of methanol in the folate-deficient acatalasemic mouse. ( Smith, EN; Taylor, RT, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (42.86) | 18.7374 |
| 1990's | 7 (33.33) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weinberg, L | 1 |
| Stewart, J | 1 |
| Wyatt, JP | 1 |
| Mathew, J | 1 |
| Datta, NJ | 1 |
| Namasivayam, A | 2 |
| González-Quevedo, A | 1 |
| Obregón, F | 1 |
| Urbina, M | 1 |
| Roussó, T | 1 |
| Lima, L | 1 |
| FATTERPAKER, P | 2 |
| MARFATIA, U | 2 |
| SREENIVASAN, A | 2 |
| Paula, EM | 1 |
| Mathangi, DC | 1 |
| Rajamani, R | 1 |
| Muthuvel, A | 1 |
| Manikandan, S | 1 |
| Srikumar, R | 1 |
| Sheeladevi, R | 1 |
| McMartin, KE | 1 |
| Collins, TD | 1 |
| Smith, EN | 1 |
| Taylor, RT | 1 |
| Garner, CD | 4 |
| Lee, EW | 4 |
| Terzo, TS | 3 |
| Louis-Ferdinand, RT | 2 |
| Dorman, DC | 2 |
| Moss, OR | 2 |
| Farris, GM | 1 |
| Janszen, D | 1 |
| Bond, JA | 2 |
| Medinsky, MA | 2 |
| Sakanashi, TM | 1 |
| Rogers, JM | 1 |
| Fu, SS | 1 |
| Connelly, LE | 1 |
| Keen, CL | 1 |
| Janszen, DB | 1 |
| Everitt, JI | 1 |
| Makar, AB | 2 |
| Tephly, TR | 3 |
| Billings, RE | 1 |
| Rietbrock, N | 2 |
| Säger, U | 1 |
| Stieren, B | 1 |
| Malorny, G | 1 |
21 other studies available for methanol and Folic Acid Deficiency
| Article | Year |
|---|---|
Unexplained drowsiness and progressive visual loss: Methanol poisoning diagnosed at autopsy.
Topics: Acidosis; Adult; Brain Edema; Fatal Outcome; Female; Folic Acid Deficiency; Humans; Methanol; Sleep | 2003 |
In vitro effect of methanol on folate-deficient rat hepatocytes.
Topics: Animals; Female; Folic Acid Deficiency; Hepatocytes; Male; Methanol; Rats; Rats, Wistar; Vitamin E | 2003 |
Effects of taurine deficiency and chronic methanol administration on rat retina, optic nerve and brain amino acids and monoamines.
Topics: Amino Acids; Animals; Asparagine; beta-Alanine; Biogenic Monoamines; Brain; Brain Chemistry; Cerebra | 2003 |
A sparing effect of formate or methanol on the impairment of creatine metabolism in folic acid deficiency.
Topics: Creatine; Ethanol; Folic Acid; Folic Acid Deficiency; Formates; Humans; Methanol | 1952 |
Rôle of folic acid and vitamin B12 in transmethylations. II. A sparing effect of formate or methanol on the impairment of creatine metabolism in folic acid deficiency.
Topics: Creatine; Ethanol; Folic Acid; Folic Acid Deficiency; Formates; Humans; Methanol; Vitamin B 12 | 1955 |
Free radical changes in methanol toxicity.
Topics: Animals; Female; Folic Acid Deficiency; Free Radical Scavengers; Free Radicals; Hydroxyl Radical; In | 2003 |
Efficacy of DL-alpha-lipoic acid on methanol induced free radical changes, protein oxidative damages and hsp70 expression in folate deficient rat nervous tissue.
Topics: Animals; Brain; Catalase; Folic Acid Deficiency; Free Radical Scavengers; Gene Expression; Glutathio | 2007 |
Relationship of alcohol metabolism to folate deficiency produced by ethanol in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Ethanol; Folic Acid; Folic Acid Deficiency; Male; Metabol | 1983 |
Acute toxicity of methanol in the folate-deficient acatalasemic mouse.
Topics: Acatalasia; Animals; Diet; Female; Folic Acid Deficiency; Formates; Male; Methanol; Methionine; Mice | 1982 |
Role of retinal metabolism in methanol-induced retinal toxicity.
Topics: Animals; Chromatography, Gas; Disulfiram; Drug Interactions; Electroretinography; Folic Acid Deficie | 1995 |
Müller cell involvement in methanol-induced retinal toxicity.
Topics: 2-Aminoadipic Acid; Adenosine Triphosphate; Administration, Oral; Aminobutyrates; Animals; Dose-Resp | 1995 |
A rat model manifesting methanol-induced visual dysfunction suitable for both acute and long-term exposure studies.
Topics: Administration, Inhalation; Administration, Oral; Animals; Chromatography, Gas; Disease Models, Anim | 1994 |
Pharmacokinetics of inhaled [14C]methanol and methanol-derived [14C]formate in normal and folate-deficient cynomolgus monkeys.
Topics: Administration, Inhalation; Animals; Carbon Dioxide; Chromatography, Gas; Disease Models, Animal; En | 1994 |
Animal model for the study of methanol toxicity: comparison of folate-reduced rat responses with published monkey data.
Topics: Administration, Inhalation; Administration, Oral; Aerosols; Animals; Disease Models, Animal; Dose-Re | 1994 |
Influence of maternal folate status on the developmental toxicity of methanol in the CD-1 mouse.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Embryo, Mammalian; Embryonic and Fetal Developmen | 1996 |
Pharmacokinetics of methanol and formate in female cynomolgus monkeys exposed to methanol vapors.
Topics: Adult; Air Pollutants; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Female; Foli | 1997 |
Methanol poisoning in the folate-deficient rat.
Topics: Animals; Folic Acid Deficiency; Formates; Hydrogen-Ion Concentration; Male; Methanol; Rats | 1976 |
Methanol poisoning VI: role of folic acid in the production of methanol poisoning in the rat.
Topics: Animals; Folic Acid; Folic Acid Deficiency; Formaldehyde; Formates; Hydrogen-Ion Concentration; Male | 1977 |
Studies on methanol toxicity and formate metabolism in isolated hepatocytes. The role of methionine in folate-dependent reactions.
Topics: Animals; Catalase; Folic Acid; Folic Acid Deficiency; Formates; Glycolates; Histidine; In Vitro Tech | 1979 |
[Influence of intermittent ethanol administration on methanol transformation in dogs].
Topics: Acidosis; Animals; Biotransformation; Dogs; Ethanol; Folic Acid; Folic Acid Deficiency; Formates; Me | 1967 |
[Effect of folic acid on methanol metabolism].
Topics: Animals; Dogs; Folic Acid; Folic Acid Deficiency; Formates; Injections, Intravenous; Methanol; Metho | 1966 |