methanol has been researched along with Acute Liver Injury, Drug-Induced in 76 studies
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.
primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.
methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Paracetamol and aspirin were used to induce hepatotoxicity and gastric ulcer in rats, respectively." | 4.12 | Evaluation of Hepatoprotective and Gastroprotective Activities of Paspalidium flavidum Leaves Extract in Experimental Animal Models. ( Ahsan, H; Anjum, I; Ismail, S; Kahrizi, D; Movafagh, A; Naveed Mushtaq, M; Ramzan, HM; Razzaq, A; Shabbir, U; Shoukat, A, 2022) |
| " In addition, the inhibitory effects of Cm-ME orally administered were tested by LPS/D-galactosamine (D-GalN)-induced hepatitis and LPS-induced peritonitis mouse models in vivo." | 3.83 | Cerbera manghas methanol extract exerts anti-inflammatory activity by targeting c-Jun N-terminal kinase in the AP-1 pathway. ( Cho, JY; Kim, D; Yi, YS, 2016) |
| "Methanol extract was found to be the most potent in in-vitro antioxidant studies." | 1.56 | Hepatoprotective effect of Ziziphus oxyphylla Edgew in paracetamol-induced hepatotoxic rat model. ( Akhtar, MS; Anjum, I; Awan, AF; Fatima, A; Haider, SI; Khan, MUR; Mushtaq, MN, 2020) |
| " Long term usage and over-dosage of diclofenac is associated with adverse effects like drug-induced liver injury, gastrointestinal and renal toxicity." | 1.51 | Protective effect of the ethanolic and methanolic leaf extracts of Madhuca longifolia against diclofenac-induced toxicity in female Wistar albino rats. ( Katturaja, R; Namachivayam, A; Nithyanandham, S; Parthasarathy, M; Prince, SE; Simon, JP, 2019) |
| " The study concludes that the extract of Alchornea cordifolia leaves has toxic potential at 800 mg kg(-1) and 1600 mg kg(-1) doses, but is safe and has beneficial effects on male reproduction when used at doses equal to or lower than 400 mg kg(-1) ." | 1.42 | Reproductive and toxic effects of methanol extract of Alchornea cordifolia leaf in male rats. ( Ajibade, TO; Olayemi, FO, 2015) |
| "Acetaminophen (APAP) is a substance that harms human health by stimulating free radical production." | 1.40 | Abrogation by Trifolium alexandrinum root extract on hepatotoxicity induced by acetaminophen in rats. ( Aziz, AT; Rehman, H; Saggu, S; Sakeran, MI; Zidan, N, 2014) |
| "The treatment with methanol exhibited a significant increase in serum hepatic and renal biochemical parameters (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, bilirubin, urea, and creatinine)." | 1.38 | Differential oxidative stress responses to methanol in intraperitoneally exposed rats: ameliorative effects of Opuntia vulgaris fruit extract. ( Ben Hsouna, A; El Feki, A; Jamoussi, K; Jaoua, S; Saoudi, M; Trigui, M, 2012) |
| "All the extracts were found to be safe up to a dose of 2000mg/kg." | 1.38 | Hibiscus vitifolius (Linn.) root extracts shows potent protective action against anti-tubercular drug induced hepatotoxicity. ( Ariamuthu, S; Chellappan, DK; Kalusalingam, A; Mohan, S; Samuel, AJ, 2012) |
| " pentaphylla is able to alter the toxic condition of the hepatocytes so as to protect the membrane integrity against paracetamol-induced leakage of marker enzymes." | 1.37 | Hepatoprotective activity of Glycosmis pentaphylla against paracetamol-induced hepatotoxicity in Swiss albino mice. ( Jain, R; Nayak, SS; Sahoo, AK, 2011) |
| "The methanol extract was purified by repeated column chromatography, resulting in the identification of five metabolites whose hepatoprotective effects were evaluated by measuring aspartate transaminase, alanine transaminase, alkaline phosphatase, glutamate, total bilirubin level, lactate dehydrogenase, total serum protein, and lipid peroxidation (thiobarbituric acid reactive substances assay) in CCl(4)-induced hepatic injury in mice." | 1.37 | Effect of flavonoids from Prosthechea michuacana on carbon tetrachloride induced acute hepatotoxicity in mice. ( Anaya Sosa, I; Hoyo Vadillo, C; Perez Gutierrez, RM; Victoria, TC, 2011) |
| "Diclofenac sodium was used as the toxicant in hepatoprotective studies, in which various serum biochemical parameters and liver glycogen were assessed." | 1.35 | Assessment of anti-inflammatory and hepatoprotective potency of Polyalthia longifolia var. pendula leaf in Wistar albino rats. ( Chanda, S; Nair, R; Tanna, A, 2009) |
| "The methanol fraction was found to be the most active, which was further supported by a significant recovery of hepatocytes in the histopathological study of the liver showing almost complete normalization of the tissues as neither the fatty accumulation nor the necrosis was observed." | 1.31 | Antihepatotoxic activity of Phyllanthus fraternus. ( Ahmed, B; al-Howiriny, TA; Mathew, R, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (9.21) | 18.7374 |
| 1990's | 8 (10.53) | 18.2507 |
| 2000's | 11 (14.47) | 29.6817 |
| 2010's | 34 (44.74) | 24.3611 |
| 2020's | 16 (21.05) | 2.80 |
| Authors | Studies |
|---|---|
| Alam, W | 1 |
| Khan, H | 1 |
| Khan, SA | 1 |
| Ali, N | 1 |
| Sharif, N | 1 |
| Ghafar, R | 1 |
| Nazir, S | 1 |
| Daglia, M | 1 |
| Gad El-Hak, HN | 1 |
| Mahmoud, HS | 1 |
| Ahmed, EA | 1 |
| Elnegris, HM | 1 |
| Aldayel, TS | 1 |
| Abdelrazek, HMA | 1 |
| Soliman, MTA | 1 |
| El-Menyawy, MAI | 1 |
| Elsayed, HE | 1 |
| Ebrahim, HY | 1 |
| Mady, MS | 1 |
| Khattab, MA | 1 |
| El-Sayed, EK | 1 |
| Moharram, FA | 2 |
| Makhuvele, R | 1 |
| Foubert, K | 1 |
| Hermans, N | 1 |
| Pieters, L | 1 |
| Verschaeve, L | 1 |
| Elgorashi, E | 1 |
| Chakrabarty, N | 1 |
| Chung, HJ | 1 |
| Alam, R | 1 |
| Emon, NU | 1 |
| Alam, S | 1 |
| Kabir, MF | 1 |
| Islam, MM | 1 |
| Hong, ST | 1 |
| Sarkar, T | 1 |
| Sarker, MMR | 1 |
| Rahman, MM | 1 |
| Sarkar, C | 1 |
| Mondal, M | 1 |
| Al-Khafaji, K | 1 |
| El-Kersh, DM | 1 |
| Jamaddar, S | 1 |
| Ray, P | 1 |
| Roy, UK | 1 |
| Afroze, M | 1 |
| Moniruzzaman, M | 1 |
| Khan, M | 1 |
| Asha, UH | 1 |
| Khalipha, ABR | 1 |
| Mori, E | 1 |
| de Lacerda, BCGV | 1 |
| Araújo, IM | 1 |
| Coutinho, HDM | 1 |
| Shill, MC | 1 |
| Islam, MT | 1 |
| Sahoo, S | 1 |
| Rath, D | 1 |
| Kar, DM | 1 |
| Pattanaik, S | 1 |
| Ayenew, KD | 1 |
| Wasihun, Y | 1 |
| Ismail, S | 1 |
| Naveed Mushtaq, M | 1 |
| Shabbir, U | 1 |
| Razzaq, A | 1 |
| Ramzan, HM | 1 |
| Shoukat, A | 1 |
| Ahsan, H | 1 |
| Movafagh, A | 1 |
| Kahrizi, D | 1 |
| Anjum, I | 2 |
| Simon, JP | 1 |
| Parthasarathy, M | 1 |
| Nithyanandham, S | 1 |
| Katturaja, R | 1 |
| Namachivayam, A | 1 |
| Prince, SE | 1 |
| Sioud, F | 1 |
| Ben Toumia, I | 1 |
| Lahmer, A | 1 |
| Khlifi, R | 1 |
| Dhaouefi, Z | 1 |
| Maatouk, M | 1 |
| Ghedira, K | 1 |
| Chekir-Ghedira, L | 1 |
| Nugrahanti, MP | 1 |
| Armalina, D | 1 |
| Partiningrum, DL | 1 |
| Fulyani, F | 1 |
| Nagy, MM | 1 |
| El Dib, RA | 1 |
| El-Tantawy, MM | 1 |
| El Hossary, GG | 1 |
| El-Hosari, DG | 1 |
| Awan, AF | 1 |
| Akhtar, MS | 1 |
| Mushtaq, MN | 1 |
| Fatima, A | 1 |
| Khan, MUR | 1 |
| Haider, SI | 1 |
| Dar, MA | 1 |
| Mir, PA | 1 |
| Masoodi, MH | 1 |
| Alqahtani, AS | 1 |
| Siddiqui, NA | 2 |
| Ahmad, B | 1 |
| Saleem, M | 1 |
| Nain, H | 1 |
| Akhtar, MF | 1 |
| Saleem, A | 1 |
| Saadullah, M | 1 |
| Mobashar, A | 1 |
| Rasul, A | 1 |
| Shah, MA | 1 |
| Hamid, I | 1 |
| Iqbal, R | 1 |
| Ilahi, I | 1 |
| Khan, J | 1 |
| Ali, H | 1 |
| Ghias, M | 1 |
| Rahim, A | 1 |
| Haq, T | 1 |
| Sajad, MA | 1 |
| Zaman, S | 1 |
| Rahim, G | 1 |
| Jan, T | 1 |
| Ahmad, S | 1 |
| Ullah, S | 1 |
| Mehreen, S | 1 |
| Zafar, H | 1 |
| Singh, K | 1 |
| Singh, N | 1 |
| Chandy, A | 1 |
| Manigauha, A | 1 |
| Matić, S | 1 |
| Stanić, S | 1 |
| Bogojević, D | 1 |
| Vidaković, M | 1 |
| Grdović, N | 1 |
| Dinić, S | 1 |
| Solujić, S | 1 |
| Mladenović, M | 1 |
| Stanković, N | 1 |
| Mihailović, M | 1 |
| Ghaffari, H | 1 |
| Venkataramana, M | 1 |
| Nayaka, SC | 1 |
| Ghassam, BJ | 1 |
| Angaswamy, N | 1 |
| Shekar, S | 1 |
| Sampath Kumara, KK | 1 |
| Prakash, HS | 1 |
| Sakeran, MI | 1 |
| Zidan, N | 1 |
| Rehman, H | 1 |
| Aziz, AT | 1 |
| Saggu, S | 1 |
| Kwape, TE | 1 |
| Chaturvedi, P | 1 |
| Kamau, JM | 1 |
| George, S | 1 |
| Raj, S | 1 |
| Gothandam, KM | 1 |
| Ajibade, TO | 1 |
| Olayemi, FO | 1 |
| Ganaie, MA | 1 |
| Khan, TH | 1 |
| Ansari, MN | 1 |
| Tukappa N K, A | 1 |
| Londonkar, RL | 1 |
| Nayaka, HB | 1 |
| Kumar C B, S | 1 |
| Onoja, SO | 1 |
| Madubuike, GK | 1 |
| Ezeja, MI | 1 |
| El-Naggar, SA | 1 |
| Abdel-Farid, IB | 1 |
| Germoush, MO | 1 |
| Elgebaly, HA | 1 |
| Alm-Eldeen, AA | 1 |
| Zakaria, ZA | 1 |
| Yahya, F | 1 |
| Mamat, SS | 1 |
| Mahmood, ND | 1 |
| Mohtarrudin, N | 1 |
| Taher, M | 1 |
| Hamid, SS | 1 |
| Teh, LK | 1 |
| Salleh, MZ | 1 |
| Yi, YS | 1 |
| Cho, JY | 1 |
| Kim, D | 1 |
| Jiang, Z | 1 |
| Wang, J | 1 |
| Xue, H | 1 |
| Wang, M | 1 |
| Jiang, H | 1 |
| Liang, Y | 1 |
| Dias, AC | 1 |
| Gregory, M | 1 |
| Chen, C | 1 |
| Zhang, X | 1 |
| Oyeyemi, IT | 1 |
| Akanni, OO | 1 |
| Adaramoye, OA | 1 |
| Bakare, AA | 2 |
| Tanna, A | 1 |
| Nair, R | 1 |
| Chanda, S | 1 |
| Abdel-Kader, MS | 1 |
| Alqasoumi, SI | 1 |
| Al-Taweel, AM | 1 |
| Coballase-Urrutia, E | 1 |
| Pedraza-Chaverri, J | 1 |
| Cárdenas-Rodríguez, N | 1 |
| Huerta-Gertrudis, B | 1 |
| García-Cruz, ME | 1 |
| Ramírez-Morales, A | 1 |
| Sánchez-González, DJ | 1 |
| Martínez-Martínez, CM | 1 |
| Camacho-Carranza, R | 1 |
| Espinosa-Aguirre, JJ | 1 |
| Singab, AN | 1 |
| Ayoub, NA | 1 |
| Ali, EN | 1 |
| Mostafa, NM | 1 |
| Nayak, SS | 1 |
| Jain, R | 1 |
| Sahoo, AK | 1 |
| Hubert, DJ | 1 |
| Dawe, A | 1 |
| Florence, NT | 1 |
| Gilbert, KD | 1 |
| Angele, TN | 1 |
| Buonocore, D | 2 |
| Finzi, PV | 2 |
| Vidari, G | 2 |
| Bonaventure, NT | 1 |
| Marzatico, F | 2 |
| Paul, MF | 1 |
| Donfack, JH | 1 |
| Simo, CC | 1 |
| Ngameni, B | 1 |
| Tchana, AN | 1 |
| Kerr, PG | 1 |
| Giardina, S | 1 |
| Ngadjui, BT | 1 |
| Moundipa, PF | 1 |
| Saoudi, M | 1 |
| Ben Hsouna, A | 1 |
| Trigui, M | 1 |
| Jamoussi, K | 1 |
| Jaoua, S | 1 |
| El Feki, A | 1 |
| Perez Gutierrez, RM | 1 |
| Anaya Sosa, I | 1 |
| Hoyo Vadillo, C | 1 |
| Victoria, TC | 1 |
| Rajamurugan, R | 2 |
| Selvaganabathy, N | 2 |
| Kumaravel, S | 1 |
| Ramamurthy, Ch | 2 |
| Sujatha, V | 2 |
| Suresh Kumar, M | 1 |
| Thirunavukkarasu, C | 2 |
| Maheshwari, P | 1 |
| Baburao, B | 1 |
| Reddy, AR | 1 |
| Badmus, JA | 1 |
| Odunola, OA | 1 |
| Samuel, AJ | 1 |
| Mohan, S | 1 |
| Chellappan, DK | 1 |
| Kalusalingam, A | 1 |
| Ariamuthu, S | 1 |
| Osadebe, PO | 1 |
| Okoye, FB | 1 |
| Uzor, PF | 1 |
| Nnamani, NR | 1 |
| Adiele, IE | 1 |
| Obiano, NC | 1 |
| Koksal, M | 1 |
| Kurcer, Z | 1 |
| Erdogan, D | 1 |
| Iraz, M | 1 |
| Tas, M | 1 |
| Eren, MA | 1 |
| Aydogan, T | 1 |
| Ulas, T | 1 |
| Haldar, PK | 1 |
| Bera, S | 1 |
| Panda, SP | 1 |
| Bhattacharya, S | 1 |
| Chaulya, NC | 1 |
| Mukherjee, A | 1 |
| Singhal, KG | 1 |
| Gupta, GD | 1 |
| Suyavaran, A | 1 |
| Reddy, GP | 1 |
| Ahmed, B | 1 |
| al-Howiriny, TA | 1 |
| Mathew, R | 1 |
| Ilavarasan, R | 1 |
| Vasudevan, M | 1 |
| Anbazhagan, S | 1 |
| Venkataraman, S | 1 |
| Shivashangari, KS | 1 |
| Ravikumar, V | 1 |
| Devaki, T | 1 |
| Vahdati-Mashhadian, N | 1 |
| Rakhshandeh, H | 1 |
| Omidi, A | 1 |
| Jhoo, JW | 1 |
| Freeman, JP | 1 |
| Heinze, TM | 1 |
| Moody, JD | 1 |
| Schnackenberg, LK | 1 |
| Beger, RD | 1 |
| Dragull, K | 1 |
| Tang, CS | 1 |
| Ang, CY | 1 |
| Lakshmi, B | 1 |
| Ajith, TA | 1 |
| Jose, N | 1 |
| Janardhanan, KK | 1 |
| Lima, CF | 1 |
| Valentao, PC | 1 |
| Andrade, PB | 1 |
| Seabra, RM | 1 |
| Fernandes-Ferreira, M | 1 |
| Pereira-Wilson, C | 1 |
| Ohta, S | 2 |
| Sato, N | 1 |
| Tu, SH | 2 |
| Shinoda, M | 2 |
| Lin, CC | 1 |
| Lin, CH | 1 |
| Allis, JW | 1 |
| Brown, BL | 1 |
| Simmons, JE | 1 |
| Hatch, GE | 1 |
| McDonald, A | 1 |
| House, DE | 1 |
| Skrzydlewska, E | 2 |
| Farbiszewski, R | 1 |
| Karan, M | 1 |
| Vasisht, K | 1 |
| Handa, SS | 1 |
| Kasacka, I | 2 |
| Sawicki, B | 1 |
| Yoshikawa, M | 1 |
| Ninomiya, K | 1 |
| Shimoda, H | 1 |
| Nishida, N | 1 |
| Matsuda, H | 1 |
| Wainwright, J | 1 |
| Schonland, MM | 1 |
| Candy, HA | 1 |
| Kumazawa, N | 1 |
| Kamogawa, A | 1 |
| Goerttler, K | 1 |
| Arnold, HP | 1 |
| Michalk, DV | 1 |
| Vilela, MP | 1 |
| Borges, DR | 1 |
| Ganc, AJ | 1 |
| Guimaraes, RX | 1 |
| Marinho, RP | 2 |
| Godoy, P | 2 |
| Raso, P | 2 |
| Neves, J | 2 |
| de Oliveira, MC | 1 |
| Berg, PA | 1 |
| Saad-Hussein, A | 1 |
| Shahy, EM | 1 |
| Shaheen, W | 1 |
| Ibrahim, KS | 1 |
| Mahdy-Abdallah, H | 1 |
| Taha, MM | 1 |
| Hafez, SF | 1 |
| Breuer, C | 1 |
| Oh, J | 1 |
| Nolkemper, D | 1 |
| Achilles, EG | 1 |
| Fischer, L | 1 |
| Eglite, I | 1 |
| Guesmer, C | 1 |
| Heitland, P | 1 |
| Koester, HD | 1 |
| Brinkert, F | 1 |
| Singer, D | 1 |
| Blohm, M | 1 |
| Shyur, LF | 1 |
| Huang, CC | 1 |
| Lo, CP | 1 |
| Chiu, CY | 1 |
| Chen, YP | 1 |
| Wang, SY | 1 |
| Chang, ST | 1 |
| Williams, PL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Oral Administration of a Herbarium Mixture (Guazuma Ulmifolia and Tecoma Stans) on Metabolic Profile in Type 2 Diabetic Patients[NCT03313856] | Phase 2/Phase 3 | 40 participants (Actual) | Interventional | 2010-01-10 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for methanol and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Pentachlorophenol, an assessment of the occupational hazard.
Topics: Abnormalities, Drug-Induced; Animals; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Ch | 1982 |
75 other studies available for methanol and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Evaluation of hepatoprotective effects of crude methanolic extract of Datura metel L. in mice.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Datura | 2021 |
Methanolic
Topics: Animals; Chemical and Drug Induced Liver Injury; Cisplatin; Male; Methanol; Phoeniceae; Plant Extrac | 2022 |
Ethnopharmacological impact of Melaleuca rugulosa (Link) Craven leaves extract on liver inflammation.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Inju | 2022 |
Protective effects of methanolic leaf extracts of Monanthotaxis caffra against aflatoxin B1-induced hepatotoxicity in rats.
Topics: Aflatoxin B1; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2022 |
Chemico-Pharmacological Screening of the Methanol Extract of
Topics: Antioxidants; Asteraceae; Chemical and Drug Induced Liver Injury; Computers; Liver; Methanol; Molecu | 2022 |
GC-MS analysis, and evaluation of protective effect of Piper chaba stem bark against paracetamol-induced liver damage in Sprague-Dawley rats: Possible defensive mechanism by targeting CYP2E1 enzyme through in silico study.
Topics: Acetaminophen; Alkaloids; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Cytochrome P-4 | 2022 |
Hepatoprotective potency of Litsea glutinosa (L.) C.B. Rob. leaf methanol extract on H
Topics: Antioxidants; Chemical and Drug Induced Liver Injury; Hep G2 Cells; Humans; Hydrogen Peroxide; Litse | 2023 |
Hepatoprotective effect of methanol extract of Agave americana leaves on paracetamol induced hepatotoxicity in Wistar albino rats.
Topics: Acetaminophen; Agave; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Gum Arabic; Methan | 2023 |
Evaluation of Hepatoprotective and Gastroprotective Activities of Paspalidium flavidum Leaves Extract in Experimental Animal Models.
Topics: Acetaminophen; Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Chemical and Drug Induced Liver In | 2022 |
Protective effect of the ethanolic and methanolic leaf extracts of Madhuca longifolia against diclofenac-induced toxicity in female Wistar albino rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspartate Amin | 2019 |
Methanolic extract of Ephedra alata ameliorates cisplatin-induced nephrotoxicity and hepatotoxicity through reducing oxidative stress and genotoxicity.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cisplatin; DNA Damage; Ephedra; Gluta | 2020 |
The effect of ranitidine administration in graded dosage to the degree of liver damage: A study on Wistar rats with acute methanol intoxication.
Topics: Animals; Anti-Ulcer Agents; Antidotes; Chemical and Drug Induced Liver Injury; Dose-Response Relatio | 2021 |
Pharmacological activity and flavonoids constituents of Artemisia judaica L aerial parts.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Antipyretics; Artemisia; Behavior, Anim | 2021 |
Hepatoprotective effect of Ziziphus oxyphylla Edgew in paracetamol-induced hepatotoxic rat model.
Topics: Acetaminophen; Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Mo | 2020 |
Amelioration of Experimental Hepatotoxicity in Rats by Portulaca oleracea Linn. from Kashmir Himalaya.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver Diseases; | 2022 |
Protective effect of Heliotropium strigosum 70% aqueous methanolic extract against paracetamol induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid | 2021 |
Hepaotoprotective and nephroprotective activities of Pistacia integerrima fruit extract in paracetamol intoxicated male rabbits with effect on blood cells count.
Topics: Acetaminophen; Animals; Blood Cell Count; Chemical and Drug Induced Liver Injury; Fruit; Kidney; Mal | 2019 |
In vivo antioxidant and hepatoprotective activity of methanolic extracts of Daucus carota seeds in experimental animals.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced | 2012 |
Methanol extract from the stem of Cotinus coggygria Scop., and its major bioactive phytochemical constituent myricetin modulate pyrogallol-induced DNA damage and liver injury.
Topics: Alanine Transaminase; Alkaline Phosphatase; Anacardiaceae; Animals; Aspartate Aminotransferases; Bil | 2013 |
Hepatoprotective action of Orthosiphon diffusus (Benth.) methanol active fraction through antioxidant mechanisms: an in vivo and in vitro evaluation.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cell Survival; Chemical and Drug Induced Liver Injury; | 2013 |
Abrogation by Trifolium alexandrinum root extract on hepatotoxicity induced by acetaminophen in rats.
Topics: Acetaminophen; Animals; Benzoquinones; Biotransformation; Chemical and Drug Induced Liver Injury; DN | 2014 |
Hepato-protective potential of methanol extract of leaf of Ziziphus mucronata (ZMLM) against dimethoate toxicity: biochemical and histological approach.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Catalase; Chemical and Drug | 2013 |
Hepatoprotective effect of polyphenols rich methanolic extract of Amorphophallus commutatus var. wayanadensis against CCl4 induced hepatic injury in swiss albino mice.
Topics: Amorphophallus; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Liver | 2014 |
Reproductive and toxic effects of methanol extract of Alchornea cordifolia leaf in male rats.
Topics: Acute Kidney Injury; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug I | 2015 |
Ameliorative effect of methanol extract of Rumex vesicarius on CCl4-induced liver damage in Wistar albino rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Male; Methanol; Plant Extract | 2015 |
Cytotoxicity and hepatoprotective attributes of methanolic extract of Rumex vesicarius L.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anticarcinogenic Agents; Antioxidants; Aspartat | 2015 |
Hepatoprotective and antioxidant activity of hydromethanolic extract of Daniella oliveri leaves in carbon tetrachloride-induced hepatotoxicity in rats.
Topics: Animals; Antioxidants; Biphenyl Compounds; Carbon Tetrachloride; Catalase; Chemical and Drug Induced | 2015 |
Efficacy of Rosmarinus officinalis leaves extract against cyclophosphamide-induced hepatotoxicity.
Topics: Animals; Antioxidants; Biomarkers; Biphenyl Compounds; Chemical and Drug Induced Liver Injury; Cyclo | 2016 |
Hepatoprotective action of various partitions of methanol extract of Bauhinia purpurea leaves against paracetamol-induced liver toxicity: involvement of the antioxidant mechanisms.
Topics: Acetaminophen; Animals; Antioxidants; Bauhinia; Chemical and Drug Induced Liver Injury; Liver; Male; | 2016 |
Cerbera manghas methanol extract exerts anti-inflammatory activity by targeting c-Jun N-terminal kinase in the AP-1 pathway.
Topics: Animals; Anti-Inflammatory Agents; Apocynaceae; Chemical and Drug Induced Liver Injury; Cytokines; D | 2016 |
Protective effect of wild Corni fructus methanolic extract against acute alcoholic liver injury in mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced | 2017 |
Methanol extract of Nymphaea lotus ameliorates carbon tetrachloride-induced chronic liver injury in rats via inhibition of oxidative stress.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Male; Methanol; Nymphaea; Oxi | 2017 |
Assessment of anti-inflammatory and hepatoprotective potency of Polyalthia longifolia var. pendula leaf in Wistar albino rats.
Topics: Acetone; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Chemi | 2009 |
Hepatoprotective constituents from Cleome droserifolia.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbohy | 2009 |
Hepatoprotective effect of acetonic and methanolic extracts of Heterotheca inuloides against CCl(4)-induced toxicity in rats.
Topics: Acetone; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Asteraceae; Carbo | 2011 |
Antioxidant and hepatoprotective activities of Egyptian moraceous plants against carbon tetrachloride-induced oxidative stress and liver damage in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, | 2010 |
Hepatoprotective activity of Glycosmis pentaphylla against paracetamol-induced hepatotoxicity in Swiss albino mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Dose-Respo | 2011 |
In vitro hepatoprotective and antioxidant activities of crude extract and isolated compounds from Ficus gnaphalocarpa.
Topics: Animals; Antioxidants; beta Carotene; Cell Death; Cell Line, Tumor; Chemical and Drug Induced Liver | 2011 |
Antihepatotoxic and antioxidant activities of methanol extract and isolated compounds from Ficus chlamydocarpa.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Carb | 2010 |
Differential oxidative stress responses to methanol in intraperitoneally exposed rats: ameliorative effects of Opuntia vulgaris fruit extract.
Topics: Analysis of Variance; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Flavonoids; Free | 2012 |
Effect of flavonoids from Prosthechea michuacana on carbon tetrachloride induced acute hepatotoxicity in mice.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography; C | 2011 |
Identification, quantification of bioactive constituents, evaluation of antioxidant and in vivo acute toxicity property from the methanol extract of Vernonia cinerea leaf extract.
Topics: Animals; Antioxidants; Asteraceae; Chemical and Drug Induced Liver Injury; Chromatography, Thin Laye | 2011 |
Hepatoprotective activity of methanolic extract of Hiptage bengalensis leaves against CCl₄-induced hepatotoxicity in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon | 2012 |
Effect of defatted methanolic extract of Holarrhena floribunda leaves in sodium arsenite-induced clastogenecity in Wistar albino rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Arsenites; Aspartate Aminotransferases; Chemical and Dr | 2010 |
Hibiscus vitifolius (Linn.) root extracts shows potent protective action against anti-tubercular drug induced hepatotoxicity.
Topics: Administration, Oral; Alkanes; Animals; Antioxidants; Antitubercular Agents; Biomarkers; Chemical an | 2012 |
Phytochemical analysis, hepatoprotective and antioxidant activity of Alchornea cordifolia methanol leaf extract on carbon tetrachloride-induced hepatic damage in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Euphorbiaceae; | 2012 |
Effect of melatonin and n-acetylcysteine on hepatic injury in rat induced by methanol intoxication: a comparative study.
Topics: Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Ani | 2012 |
Hepatoprotective activity of Cyperus tegetum rhizome against paracetamol-induced liver damage in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cyperus; L | 2011 |
Hepatoprotective and antioxidant activity of methanolic extract of flowers of Nerium oleander against CCl4-induced liver injury in rats.
Topics: Alkaline Phosphatase; Animals; Antioxidants; Benzothiazoles; Biphenyl Compounds; Carbon Tetrachlorid | 2012 |
Brassica nigra plays a remedy role in hepatic and renal damage.
Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease M | 2012 |
Antihepatotoxic activity of Phyllanthus fraternus.
Topics: Alanine Transaminase; Albumins; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning | 2002 |
Antioxidant activity of Thespesia populnea bark extracts against carbon tetrachloride-induced liver injury in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride Poisoning; Catalase; Chemical and Drug Induced Liver Inj | 2003 |
Evaluation of the protective efficacy of Asteracantha longifolia on acetaminophen-induced liver damage in rats.
Topics: Acanthaceae; Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotran | 2004 |
An investigation on LD50 and subacute hepatic toxicity of Nigella sativa seed extracts in mice.
Topics: Alkaline Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Chloroform; Lethal Dose 50; M | 2005 |
In vitro cytotoxicity of nonpolar constituents from different parts of kava plant (Piper methysticum).
Topics: Aspartate Aminotransferases; Cell Line; Chemical and Drug Induced Liver Injury; Flavonoids; Kava; L- | 2006 |
Antimutagenic activity of methanolic extract of Ganoderma lucidum and its effect on hepatic damage caused by benzo[a]pyrene.
Topics: Animals; Antimutagenic Agents; Antioxidants; Benzo(a)pyrene; Chemical and Drug Induced Liver Injury; | 2006 |
Water and methanolic extracts of Salvia officinalis protect HepG2 cells from t-BHP induced oxidative damage.
Topics: Biphenyl Compounds; Cell Death; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Comet Assa | 2007 |
[Protective effects of Taiwan crude drugs on experimental liver injuries].
Topics: 1-Naphthylisothiocyanate; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver I | 1993 |
Pharmacological and pathological studies on Taiwan folk medicine (IX): The hepatoprotective effect of the methanolic extract from echinops grijisii.
Topics: 1-Butanol; Acetates; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biopsy; Butanols; C | 1993 |
Methanol potentiation of carbon tetrachloride hepatotoxicity: the central role of cytochrome P450.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Syste | 1996 |
Trolox-derivative antioxidant protects against methanol-induced damage.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Chromans; Erythrocytes; Glutathione; | 1997 |
Antihepatotoxic activity of Swertia chirata on carbon tetrachloride induced hepatotoxicity in rats.
Topics: Animals; Butanols; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorofor | 1999 |
The preliminary evaluation of liver damage in rats intoxicated with methanol.
Topics: Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; Methanol; Necrosis; Pilot Pr | 1999 |
Parenchymal cell mitochondria in the liver of rats after methanol intoxication.
Topics: Animals; Chemical and Drug Induced Liver Injury; L-Lactate Dehydrogenase; Liver; Liver Diseases; Mal | 1999 |
Hepatoprotective and antioxidative properties of Salacia reticulata: preventive effects of phenolic constituents on CCl4-induced liver injury in mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Biphenyl Compounds; Carbon | 2002 |
Toxicity of Callilepis laureola.
Topics: Animals; Atractyloside; Chemical and Drug Induced Liver Injury; Kidney Tubular Necrosis, Acute; Meth | 1977 |
[Protective effects of various methanol extracts of crude drugs on experimental hepatic injury induced by alpha-naphthylisothiocyanate in rats].
Topics: 1-Naphthylisothiocyanate; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Depression, Ch | 1991 |
[Carcinogen-induced diaplacental effects in the rat. (Histological findings and the kinetics of DNA metabolism following the application of aflatoxin B1, methylazoxymethanol-acetate, and ethylnitrosourea)].
Topics: Acetates; Aflatoxins; Animals; Azo Compounds; Brain; Brain Diseases; Carcinogens; Chemical and Drug | 1970 |
[Hepatic and psychological manifestations following hycanthone administration].
Topics: Adolescent; Anthelmintics; Anthracenes; Chemical and Drug Induced Liver Injury; Cognition Disorders; | 1972 |
[Hepatopathy after treatment of S. mansoni with hycanthone. I. Report of a case of acute yellow atrophy].
Topics: Adult; Anthelmintics; Chemical and Drug Induced Liver Injury; Ethylenediamines; Humans; Liver; Male; | 1974 |
[Hepatopathy after treatment of schistosomiasis mansoni with hycanthone. II. Report of a case of death after 30 days of treatment].
Topics: Adult; Anthelmintics; Chemical and Drug Induced Liver Injury; Drug Evaluation; Ethylenediamines; Fem | 1974 |
[Serologic studies in patients with alcoholic liver disease and their importance in differential diagnosis].
Topics: Alcoholism; Antibodies; Autoantibodies; Autoimmune Diseases; Chemical and Drug Induced Liver Injury; | 1971 |
Hepatotoxicity of aflatoxin B1 and its oxidative effects in wood dust Egyptian exposed workers.
Topics: Adult; Aflatoxin B1; Antioxidants; Aspergillus; Chemical and Drug Induced Liver Injury; Cross-Sectio | 2021 |
Successful detoxification and liver transplantation in a severe poisoning with a chemical wood preservative containing chromium, copper, and arsenic.
Topics: Arsenates; Chelating Agents; Chemical and Drug Induced Liver Injury; Child, Preschool; Heavy Metal P | 2015 |
Hepatoprotective phytocompounds from Cryptomeria japonica are potent modulators of inflammatory mediators.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Cryptomeria; Cyclo | 2008 |