methanol has been researched along with Abnormalities, Drug-Induced in 27 studies
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.
primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.
methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Exposure of pregnant CD-1 mice to methanol (MeOH) by inhalation on gestation days (gd) 6-15 results in dose-related increases in fetal cleft palate, exencephaly, and skeletal defects." | 3.69 | Critical periods of sensitivity to the developmental toxicity of inhaled methanol in the CD-1 mouse. ( Mole, ML; Rogers, JM, 1997) |
| " The uncertainties in this conclusion are based on the lack of information on dose-response relationship at reasonable, projected exposure levels and of studies examining end points of concern in sensitive species." | 2.38 | Health effects of oxygenated fuels. ( Costantini, MG, 1993) |
| "No maternal intoxication was apparent, but the high dosage level caused a transient deficit in maternal weight gain." | 1.32 | Methanol exposure during gastrulation causes holoprosencephaly, facial dysgenesis, and cervical vertebral malformations in C57BL/6J mice. ( Barbee, BD; Brannen, KC; Degitz, SJ; Rogers, JM; Zucker, RM, 2004) |
| "Methanol is toxic to embryos of mice and rats when inhaled by dams at high concentrations." | 1.29 | Phase-specific developmental toxicity in mice following maternal methanol inhalation. ( Bolon, B; Dorman, DC; Janszen, D; Morgan, KT; Welsch, F, 1993) |
| " One dam died in each of the 7,500, 10,000, and 15,000 ppm methanol exposure groups, but no dose-response relationship was evident for maternal death." | 1.29 | The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose-response modeling for estimation of benchmark doses. ( Barbee, BD; Chernoff, N; Kavlock, RJ; Logsdon, TR; Mole, ML; Rogers, JM; Turner, CI, 1993) |
| "Fetal body weights were lowest in the low folic acid groups and significantly lower in the methanol groups relative to vehicle-treated animals." | 1.29 | Influence of maternal folate status on the developmental toxicity of methanol in the CD-1 mouse. ( Connelly, LE; Fu, SS; Keen, CL; Rogers, JM; Sakanashi, TM, 1996) |
| "Methanol was administered at 20,000 ppm (20ME), 10,000 ppm (10ME), 5000 ppm (5ME), and 0 ppm (MECO) for 7 hr/day on Days 1-19 of gestation (Days 7-15 for 20ME)." | 1.27 | Teratological assessment of methanol and ethanol at high inhalation levels in rats. ( Brightwell, WS; Burg, JR; Goad, PT; Khan, A; MacKenzie, DR; Nelson, BK; Weigel, WW, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (40.74) | 18.7374 |
| 1990's | 9 (33.33) | 18.2507 |
| 2000's | 3 (11.11) | 29.6817 |
| 2010's | 4 (14.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sweeting, JN | 2 |
| Wells, PG | 3 |
| Downing, C | 1 |
| Johnson, TE | 1 |
| Larson, C | 1 |
| Leakey, TI | 1 |
| Siegfried, RN | 1 |
| Rafferty, TM | 1 |
| Cooney, CA | 1 |
| Siu, M | 1 |
| Wiley, MJ | 2 |
| Siu, MT | 1 |
| Starr, TB | 1 |
| Festa, JL | 1 |
| Rogers, JM | 6 |
| Brannen, KC | 1 |
| Barbee, BD | 2 |
| Zucker, RM | 2 |
| Degitz, SJ | 2 |
| Hunter, ES | 1 |
| Costantini, MG | 1 |
| Bolon, B | 1 |
| Dorman, DC | 1 |
| Janszen, D | 1 |
| Morgan, KT | 1 |
| Welsch, F | 1 |
| Mole, ML | 2 |
| Chernoff, N | 1 |
| Turner, CI | 1 |
| Logsdon, TR | 1 |
| Kavlock, RJ | 1 |
| Sakanashi, TM | 1 |
| Fu, SS | 1 |
| Connelly, LE | 2 |
| Keen, CL | 1 |
| Andrews, JE | 1 |
| Ebron-Mccoy, M | 1 |
| Schmid, JE | 1 |
| Svendsgaard, D | 1 |
| Nelson, BK | 1 |
| Brightwell, WS | 1 |
| MacKenzie, DR | 1 |
| Khan, A | 1 |
| Burg, JR | 1 |
| Weigel, WW | 1 |
| Goad, PT | 1 |
| Bariliak, IR | 1 |
| Alekhina, TN | 1 |
| Cekanova, E | 1 |
| Larsson, KS | 1 |
| Mörck, E | 1 |
| Aberg, G | 1 |
| Moore, JA | 1 |
| Matsumoto, H | 1 |
| Spatz, M | 1 |
| Laqueur, GL | 1 |
| Fischer, MH | 1 |
| Welker, C | 1 |
| Waisman, HA | 1 |
| Stenger, EG | 1 |
| Aeppli, L | 1 |
| Machemer, L | 1 |
| Müller, D | 1 |
| Trokan, J | 1 |
| Nakamura, K | 1 |
| Suzuki, A | 1 |
| Williams, PL | 1 |
| Copeland, TL | 1 |
| Paustenbach, DJ | 1 |
| Harris, MA | 1 |
| Otani, J | 1 |
| Dimich-Ward, H | 1 |
| Hertzman, C | 1 |
| Teschke, K | 1 |
| Hershler, R | 1 |
| Marion, SA | 1 |
| Ostry, A | 1 |
| Kelly, S | 1 |
| Sandermann, W | 1 |
3 reviews available for methanol and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
A proposed inhalation reference concentration for methanol.
Topics: Abnormalities, Drug-Induced; Administration, Inhalation; Animals; Environmental Pollutants; Female; | 2003 |
Health effects of oxygenated fuels.
Topics: Abnormalities, Drug-Induced; Animals; Ethers; Gasoline; Methanol; Methyl Ethers; Reproduction; Solve | 1993 |
Pentachlorophenol, an assessment of the occupational hazard.
Topics: Abnormalities, Drug-Induced; Animals; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Ch | 1982 |
24 other studies available for methanol and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
New Zealand white rabbit progeny exposed in utero to methanol are resistant to skeletal anomalies reported for rodents, but exhibit a novel vertebral defect.
Topics: Abnormalities, Drug-Induced; Animals; Female; Gestational Age; Maternal Exposure; Methanol; Mice; Mo | 2015 |
Subtle decreases in DNA methylation and gene expression at the mouse Igf2 locus following prenatal alcohol exposure: effects of a methyl-supplemented diet.
Topics: Abnormalities, Drug-Induced; Animals; Betaine; Choline; Diet; DNA Methylation; Drug Resistance; Etha | 2011 |
Species- and strain-dependent teratogenicity of methanol in rabbits and mice.
Topics: Abnormalities, Drug-Induced; Animals; Area Under Curve; Catalase; Embryo, Mammalian; Embryonic Devel | 2011 |
Methanol teratogenicity in mutant mice with deficient catalase activity and transgenic mice expressing human catalase.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acatalasia; Animals; Catalase; Embryo, Mammali | 2013 |
Methanol exposure during gastrulation causes holoprosencephaly, facial dysgenesis, and cervical vertebral malformations in C57BL/6J mice.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Bone Development; Cervical Vertebrae; | 2004 |
Developmental toxicity of methanol: Pathogenesis in CD-1 and C57BL/6J mice exposed in whole embryo culture.
Topics: Abnormalities, Drug-Induced; Animals; Apoptosis; Bone and Bones; Cell Cycle; Embryonic Development; | 2004 |
Phase-specific developmental toxicity in mice following maternal methanol inhalation.
Topics: Abnormalities, Drug-Induced; Animals; Female; Gestational Age; Male; Methanol; Mice; Mice, Inbred St | 1993 |
The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose-response modeling for estimation of benchmark doses.
Topics: Abnormalities, Drug-Induced; Administration, Inhalation; Animals; Dose-Response Relationship, Drug; | 1993 |
Influence of maternal folate status on the developmental toxicity of methanol in the CD-1 mouse.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Embryo, Mammalian; Embryonic and Fetal Developmen | 1996 |
Methanol causes posteriorization of cervical vertebrae in mice.
Topics: Abnormalities, Drug-Induced; Animals; Cervical Vertebrae; Dose-Response Relationship, Drug; Female; | 1997 |
Critical periods of sensitivity to the developmental toxicity of inhaled methanol in the CD-1 mouse.
Topics: Abnormalities, Drug-Induced; Administration, Inhalation; Animals; Bone and Bones; Brain; Cervical Ve | 1997 |
Effects of combinations of methanol and formic acid on rat embryos in culture.
Topics: Abnormalities, Drug-Induced; Animals; Culture Techniques; Dose-Response Relationship, Drug; Drug Int | 1998 |
Teratological assessment of methanol and ethanol at high inhalation levels in rats.
Topics: Abnormalities, Drug-Induced; Air Pollutants; Animals; Dose-Response Relationship, Drug; Ethanol; Fem | 1985 |
[Effect of pentoxyl on the intrauterine development of rats].
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Gestational Age; Immobilization; In | 1973 |
Interactions between salicylic acid and pyridyl-3-methanol: anti-inflammatory and teratogenic effects.
Topics: Abnormalities, Drug-Induced; Acid Phosphatase; Animals; Cell Membrane; Drug Interactions; Drug Syner | 1974 |
Teratogenicity of hycanthone in mice.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Bone and Bones; Ethylamines; Female; | 1972 |
Hycanthone for schistosomiasis.
Topics: Abnormalities, Drug-Induced; Anthelmintics; Ethylenediamines; Fatty Liver; Humans; Methanol; Neoplas | 1974 |
Quantitative changes with age in the DNA content of methylazoxymethanol-induced microencephalic rat brain.
Topics: Abnormalities, Drug-Induced; Age Factors; Animals; Azo Compounds; Brain; Cerebellum; Cerebral Cortex | 1972 |
Generalized growth retardation in rats induced by prenatal exposure to methylazoxymethyl acetate.
Topics: Abnormalities, Drug-Induced; Animals; Azo Compounds; Birth Weight; Brain; Female; Gestational Age; G | 1972 |
[Toxicity of propyleneglykol-monomethylether].
Topics: 1-Propanol; Abnormalities, Drug-Induced; Administration, Oral; Animals; Autopsy; Dogs; Ethers; Femal | 1972 |
[Experiences on the congenital malformations of the brain caused by intervention of certain agents. (Study on the fetus of the Wistar rat)].
Topics: Abnormalities, Drug-Induced; Animals; Brain; Congenital Abnormalities; Electrocoagulation; Ethanol; | 1967 |
Comparing the results of a Monte Carlo analysis with EPA's reasonable maximum exposed individual (RMEI): a case study of a former wood treatment site.
Topics: Abnormalities, Drug-Induced; Algorithms; Animals; Benzofurans; Dibenzofurans, Polychlorinated; Dose- | 1993 |
Reproductive effects of paternal exposure to chlorophenate wood preservatives in the sawmill industry.
Topics: Abnormalities, Drug-Induced; Adult; British Columbia; Chlorophenols; Cohort Studies; Dioxins; Female | 1996 |
[Polychlorinated aromatic compounds as environmental poisons].
Topics: Abnormalities, Drug-Induced; Animals; Cattle; Chemical Phenomena; Chemistry; DDT; Dermatitis, Occupa | 1974 |