methane has been researched along with Pulmonary Fibrosis in 86 studies
Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed)
methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inflammation, fibrosis, and malignancy are complex pathological processes that, in summation, underlie a major portion of human disease." | 2.61 | Integration of inflammation, fibrosis, and cancer induced by carbon nanotubes. ( Dong, J; Ma, Q, 2019) |
| "Pulmonary fibrosis is an important adverse outcome related to inhalation exposure to MWCNTs and one that the non-animal approach should be able to assess." | 2.53 | Predicting pulmonary fibrosis in humans after exposure to multi-walled carbon nanotubes (MWCNTs). ( Castranova, V; Clippinger, AJ; Halappanavar, S; Nikota, J; Rothen-Rutishauser, B; Sharma, M, 2016) |
| " Comparative toxicity studies in which mice were given equal weights of test materials showed that SWCNTs were more toxic than quartz, which is considered a serious occupational health hazard if it is chronically inhaled; ultrafine carbon black was shown to produce minimal lung responses." | 2.43 | A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks. ( Arepalli, S; Hunter, RL; James, JT; Lam, CW; McCluskey, R, 2006) |
| "Lung histological damages included pulmonary fibrosis, for both MWCNT types, similarly to asbestos; single liver and kidney histological alterations were present." | 1.91 | Characterization and in vivo toxicological evaluation of multi-walled carbon nanotubes: a low-dose repeated intratracheal administration study. ( Altknecht, LF; Amaral, MG; Arbo, MD; Bergmann, CP; Bubols, GB; Cestonaro, LV; Fão, N; Garcia, SC; Göethel, G; Guterres, SS; Nascimento, SN; Paese, K; Peruzzi, CP; Pohlmann, AR, 2023) |
| "Pulmonary fibrosis is a poorly understood pathologic condition." | 1.48 | Carbon nanotubes and crystalline silica induce matrix remodeling and contraction by stimulating myofibroblast transformation in a three-dimensional culture of human pulmonary fibroblasts: role of dimension and rigidity. ( Hindman, B; Ma, Q, 2018) |
| "Therefore, both rigidity and genetic susceptibility should be major considerations for risk assessment of MWCNTs." | 1.46 | STAT1-dependent and -independent pulmonary allergic and fibrogenic responses in mice after exposure to tangled versus rod-like multi-walled carbon nanotubes. ( Bonner, JC; Dandley, EC; Duke, KS; Ihrie, MD; Parsons, GN; Shipkowski, KA; Taylor-Just, AJ; Thompson, EA, 2017) |
| "Thus, MWCNT-induced carcinogenesis may involve ongoing low levels of DNA damage in an environment of persisting fibres, chronic inflammation and tissue irritation, and parallel increases or decreases in the expression of genes involved in several pro-carcinogenic pathways." | 1.46 | Multi-walled carbon nanotube-induced genotoxic, inflammatory and pro-fibrotic responses in mice: Investigating the mechanisms of pulmonary carcinogenesis. ( Aziz, SA; Halappanavar, S; Jacobsen, NR; Rahman, L; Vogel, U; Wallin, H; White, P; Williams, A; Wu, D; Yauk, CL, 2017) |
| " In addition, we compared pulmonary responses to SWCNT by bolus dosing through pharyngeal aspiration and inhalation 5 h/day for 4 days, to evaluate the effect of dose rate." | 1.40 | Long-term effects of carbon containing engineered nanomaterials and asbestos in the lung: one year postexposure comparisons. ( Castranova, V; Chirila, MM; Hubbs, A; Kagan, VE; Keohavong, P; Kisin, ER; Murray, AR; Shvedova, AA; Sycheva, LP; Tkach, AV; Yanamala, N, 2014) |
| "In this study, we examined the pulmonary fibrosis response to different length of MWCNT including short MWCNT (S-MWCNT, length=350-700nm) and long MWCNT (L-MWCNT, length=5-15μm) and investigated whether the epithelial-mesenchymal transition (EMT) occurred during MWCNT-induced pulmonary fibrosis." | 1.40 | Epithelial-mesenchymal transition involved in pulmonary fibrosis induced by multi-walled carbon nanotubes via TGF-beta/Smad signaling pathway. ( Chen, T; Chen, Z; Cui, X; Gao, X; Jia, G; Nie, H; Pu, J; Wang, H; Wang, Y; Yang, J, 2014) |
| "Mice exposed to MWCNTs develop pulmonary fibrosis." | 1.40 | Atomic layer deposition coating of carbon nanotubes with aluminum oxide alters pro-fibrogenic cytokine expression by human mononuclear phagocytes in vitro and reduces lung fibrosis in mice in vivo. ( Bonner, JC; Garantziotis, S; Hussain, S; McClure, CD; Parsons, GN; Shipkowski, KA; Taylor, AJ; Thompson, EA, 2014) |
| " However, the potential adverse effects of f-CNTs have not been quantitatively or systematically explored." | 1.39 | Surface charge and cellular processing of covalently functionalized multiwall carbon nanotubes determine pulmonary toxicity. ( Chang, CH; Hwang, AA; Ji, Z; Li, R; Li, Z; Liao, YP; Lin, S; Meng, H; Nel, AE; Song, TB; Sun, B; Wang, M; Wang, X; Xia, T; Xu, R; Yang, Y; Zhang, H; Zink, JI, 2013) |
| " We assessed the onset of pulmonary toxic effects caused by pristine MW-CNTs and functionalized MW-NH₂ or MW-COOH, 16 days after intratracheal instillation (1 mg/kg b." | 1.37 | Comparative pulmonary toxicity assessment of pristine and functionalized multi-walled carbon nanotubes intratracheally instilled in rats: morphohistochemical evaluations. ( Acerbi, D; Barni, S; Coccini, T; Manzo, L; Roda, E; Vaccarone, R, 2011) |
| "Rapid development of pulmonary fibrosis in mice that inhaled CNT was also confirmed by significant increases in the collagen level." | 1.37 | Pulmonary biocompatibility assessment of inhaled single-wall and multiwall carbon nanotubes in BALB/c mice. ( Baluchamy, S; Biradar, S; Goornavar, V; Gopikrishnan, R; Hall, JC; Jeffers, R; Ramesh, GT; Ramesh, V; Ravichandran, P; Thomas, R; Wilson, BL, 2011) |
| " Dose-response determined at 56 days post-exposure for the average thickness of connective tissue in alveolar septa was 0." | 1.37 | Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes. ( Battelli, LA; Castranova, V; Friend, S; Hubbs, AF; Mercer, RR; Porter, DW; Scabilloni, JF; Wang, L, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (5.81) | 29.6817 |
| 2010's | 68 (79.07) | 24.3611 |
| 2020's | 13 (15.12) | 2.80 |
| Authors | Studies |
|---|---|
| Fraser, K | 1 |
| Hubbs, A | 2 |
| Yanamala, N | 4 |
| Mercer, RR | 9 |
| Stueckle, TA | 3 |
| Jensen, J | 1 |
| Eye, T | 1 |
| Battelli, L | 4 |
| Clingerman, S | 1 |
| Fluharty, K | 1 |
| Dodd, T | 1 |
| Casuccio, G | 1 |
| Bunker, K | 1 |
| Lersch, TL | 1 |
| Kashon, ML | 1 |
| Orandle, M | 1 |
| Dahm, M | 1 |
| Schubauer-Berigan, MK | 2 |
| Kodali, V | 1 |
| Erdely, A | 1 |
| Soliman, E | 1 |
| Bhalla, S | 1 |
| Elhassanny, AEM | 1 |
| Malur, A | 3 |
| Ogburn, D | 1 |
| Leffler, N | 2 |
| Malur, AG | 1 |
| Thomassen, MJ | 2 |
| Gromelski, M | 1 |
| Stoliński, F | 1 |
| Jagiello, K | 2 |
| Rybińska-Fryca, A | 2 |
| Williams, A | 5 |
| Halappanavar, S | 7 |
| Vogel, U | 6 |
| Puzyn, T | 2 |
| Zhang, XL | 1 |
| Li, B | 1 |
| Zhang, X | 3 |
| Zhu, J | 1 |
| Xie, Y | 1 |
| Shen, T | 2 |
| Tang, W | 1 |
| Zhang, J | 1 |
| Murphy, F | 1 |
| Jacobsen, NR | 3 |
| Di Ianni, E | 1 |
| Johnston, H | 1 |
| Braakhuis, H | 1 |
| Peijnenburg, W | 1 |
| Oomen, A | 1 |
| Fernandes, T | 1 |
| Stone, V | 1 |
| Pantzke, J | 2 |
| Offer, S | 2 |
| Zimmermann, EJ | 2 |
| Kuhn, E | 2 |
| Streibel, T | 2 |
| Oeder, S | 2 |
| Di Bucchianico, S | 2 |
| Zimmermann, R | 2 |
| Bubols, GB | 1 |
| Arbo, MD | 1 |
| Peruzzi, CP | 1 |
| Cestonaro, LV | 1 |
| Altknecht, LF | 1 |
| Fão, N | 1 |
| Göethel, G | 1 |
| Nascimento, SN | 1 |
| Paese, K | 1 |
| Amaral, MG | 1 |
| Bergmann, CP | 1 |
| Pohlmann, AR | 1 |
| Guterres, SS | 1 |
| Garcia, SC | 1 |
| Hu, X | 1 |
| Zhang, Y | 3 |
| Liu, B | 2 |
| Pan, H | 1 |
| Liu, Z | 1 |
| Yao, Z | 1 |
| Zhu, Q | 1 |
| Wu, C | 1 |
| Miyauchi, A | 1 |
| Akashi, T | 1 |
| Yokota, S | 1 |
| Taquahashi, Y | 1 |
| Hirose, A | 1 |
| Hojo, M | 1 |
| Yoshida, H | 1 |
| Kurokawa, M | 1 |
| Watanabe, W | 1 |
| Lee, HY | 1 |
| You, DJ | 1 |
| Taylor-Just, A | 1 |
| Tisch, LJ | 1 |
| Bartone, RD | 1 |
| Atkins, HM | 1 |
| Ralph, LM | 1 |
| Antoniak, S | 1 |
| Bonner, JC | 10 |
| Dong, J | 10 |
| Ma, Q | 10 |
| Kiratipaiboon, C | 1 |
| Voronkova, M | 1 |
| Ghosh, R | 1 |
| Rojanasakul, LW | 2 |
| Dinu, CZ | 2 |
| Chen, YC | 1 |
| Rojanasakul, Y | 8 |
| Willliams, A | 1 |
| Duke, KS | 3 |
| Taylor-Just, AJ | 1 |
| Ihrie, MD | 2 |
| Shipkowski, KA | 3 |
| Thompson, EA | 2 |
| Dandley, EC | 3 |
| Parsons, GN | 4 |
| Nikota, J | 2 |
| Banville, A | 1 |
| Goodwin, LR | 1 |
| Wu, D | 2 |
| Yauk, CL | 4 |
| Wallin, H | 4 |
| Rahman, L | 1 |
| Aziz, SA | 1 |
| White, P | 1 |
| Honda, K | 1 |
| Naya, M | 1 |
| Takehara, H | 1 |
| Kataura, H | 1 |
| Fujita, K | 1 |
| Ema, M | 1 |
| Hindman, B | 1 |
| Mohan, A | 1 |
| Barrington, RA | 1 |
| Muller-Borer, B | 1 |
| Murray, G | 1 |
| Kew, K | 1 |
| Zhou, C | 1 |
| Russell, J | 1 |
| Jones, JL | 1 |
| Wingard, CJ | 2 |
| Barna, BP | 1 |
| Bing, Q | 1 |
| Li, S | 2 |
| Han, B | 1 |
| Lu, J | 1 |
| Baiyun, R | 1 |
| Lv, Y | 1 |
| Wu, H | 1 |
| Zhang, Z | 1 |
| Wang, K | 1 |
| Shi, L | 1 |
| Linthicum, W | 1 |
| Man, K | 1 |
| He, X | 2 |
| Wen, Q | 1 |
| Yang, Y | 4 |
| Li, R | 3 |
| Wang, X | 5 |
| Ji, Z | 4 |
| Sun, B | 3 |
| Zhang, H | 4 |
| Chang, CH | 2 |
| Lin, S | 3 |
| Meng, H | 3 |
| Liao, YP | 3 |
| Wang, M | 4 |
| Li, Z | 1 |
| Hwang, AA | 1 |
| Song, TB | 2 |
| Xu, R | 1 |
| Zink, JI | 1 |
| Nel, AE | 4 |
| Xia, T | 4 |
| Wang, P | 1 |
| Nie, X | 1 |
| Wang, Y | 2 |
| Li, Y | 2 |
| Ge, C | 1 |
| Zhang, L | 1 |
| Wang, L | 8 |
| Bai, R | 1 |
| Chen, Z | 3 |
| Zhao, Y | 1 |
| Chen, C | 1 |
| Di, YP | 1 |
| Tkach, AV | 3 |
| Stanley, S | 1 |
| Gao, S | 1 |
| Shurin, MR | 1 |
| Kisin, ER | 5 |
| Kagan, VE | 4 |
| Shvedova, A | 1 |
| Snyder-Talkington, BN | 4 |
| Dymacek, J | 2 |
| Porter, DW | 9 |
| Wolfarth, MG | 5 |
| Pacurari, M | 1 |
| Denvir, J | 1 |
| Castranova, V | 15 |
| Qian, Y | 4 |
| Guo, NL | 4 |
| Scabilloni, JF | 3 |
| Hubbs, AF | 4 |
| Battelli, LA | 3 |
| McKinney, W | 2 |
| Friend, S | 2 |
| Andrew, M | 3 |
| Vietti, G | 3 |
| Ibouraadaten, S | 2 |
| Palmai-Pallag, M | 2 |
| Yakoub, Y | 2 |
| Bailly, C | 1 |
| Fenoglio, I | 2 |
| Marbaix, E | 2 |
| Lison, D | 3 |
| van den Brule, S | 3 |
| Sager, TM | 1 |
| Wolfarth, MW | 1 |
| Leonard, SS | 1 |
| Steinbach, T | 1 |
| Endo, M | 1 |
| Tsuruoka, S | 1 |
| Shvedova, AA | 6 |
| Murray, AR | 3 |
| Chirila, MM | 1 |
| Keohavong, P | 1 |
| Sycheva, LP | 1 |
| Chen, T | 1 |
| Nie, H | 1 |
| Gao, X | 1 |
| Yang, J | 1 |
| Pu, J | 1 |
| Cui, X | 1 |
| Wang, H | 1 |
| Jia, G | 1 |
| Manke, A | 2 |
| Luanpitpong, S | 1 |
| Dong, C | 3 |
| Derk, R | 2 |
| Sager, T | 1 |
| Gou, H | 1 |
| Wu, N | 2 |
| Hussain, S | 3 |
| Sangtian, S | 1 |
| Anderson, SM | 1 |
| Snyder, RJ | 1 |
| Marshburn, JD | 1 |
| Rice, AB | 1 |
| Garantziotis, S | 3 |
| Taylor, AJ | 3 |
| McClure, CD | 1 |
| Batteli, LA | 1 |
| Richardson, DL | 1 |
| Poulsen, SS | 1 |
| Saber, AT | 1 |
| Andersen, O | 1 |
| Købler, C | 1 |
| Atluri, R | 1 |
| Pozzebon, ME | 1 |
| Mucelli, SP | 1 |
| Simion, M | 1 |
| Rickerby, D | 1 |
| Mortensen, A | 1 |
| Jackson, P | 1 |
| Kyjovska, ZO | 1 |
| Mølhave, K | 1 |
| Jensen, KA | 1 |
| Sargent, LM | 1 |
| Staska, LM | 1 |
| Raese, R | 2 |
| Chen, BT | 1 |
| Lowry, DT | 1 |
| Reynolds, SH | 1 |
| Brown, TA | 1 |
| Lee, JW | 1 |
| Holian, A | 1 |
| Porter, V | 1 |
| Fredriksen, H | 1 |
| Kim, M | 1 |
| Cho, YH | 1 |
| Piret, JP | 1 |
| Mishra, A | 2 |
| Fatkhutdinova, LM | 1 |
| Khaliullin, TO | 1 |
| Vasil'yeva, OL | 1 |
| Zalyalov, RR | 1 |
| Mustafin, IG | 1 |
| Birch, ME | 1 |
| Labib, S | 1 |
| Nikota, JK | 1 |
| Ducatman, B | 1 |
| Sharma, M | 1 |
| Rothen-Rutishauser, B | 1 |
| Clippinger, AJ | 1 |
| Polimeni, M | 1 |
| Gulino, GR | 1 |
| Gazzano, E | 1 |
| Kopecka, J | 1 |
| Marucco, A | 1 |
| Cesano, F | 1 |
| Campagnolo, L | 1 |
| Magrini, A | 1 |
| Pietroiusti, A | 1 |
| Ghigo, D | 1 |
| Aldieri, E | 1 |
| Wang, Q | 1 |
| Asmani, M | 1 |
| Liu, C | 1 |
| Li, C | 2 |
| Lippmann, JM | 1 |
| Wu, Y | 1 |
| Zhao, R | 1 |
| Qin, Y | 1 |
| Zhao, G | 1 |
| Fu, X | 1 |
| Xie, X | 1 |
| Huang, Y | 1 |
| Cheng, X | 1 |
| Wei, J | 1 |
| Liu, H | 1 |
| Lai, Z | 1 |
| Hilton, GM | 1 |
| Griffith, EH | 1 |
| Bereman, MS | 1 |
| Elgrabli, D | 1 |
| Abella-Gallart, S | 1 |
| Robidel, F | 1 |
| Rogerieux, F | 1 |
| Boczkowski, J | 1 |
| Lacroix, G | 1 |
| Ishimatsu, S | 1 |
| Hori, H | 1 |
| Kasai, T | 2 |
| Ogami, A | 1 |
| Morimoto, Y | 1 |
| Oyabu, T | 1 |
| Tanaka, I | 1 |
| Ryman-Rasmussen, JP | 1 |
| Cesta, MF | 1 |
| Brody, AR | 1 |
| Shipley-Phillips, JK | 1 |
| Everitt, JI | 1 |
| Tewksbury, EW | 1 |
| Moss, OR | 1 |
| Wong, BA | 1 |
| Dodd, DE | 1 |
| Andersen, ME | 1 |
| Qiu, A | 1 |
| Lu, Y | 2 |
| Aiso, S | 1 |
| Yamazaki, K | 1 |
| Umeda, Y | 1 |
| Asakura, M | 1 |
| Takaya, M | 1 |
| Toya, T | 1 |
| Koda, S | 1 |
| Nagano, K | 1 |
| Arito, H | 1 |
| Fukushima, S | 1 |
| Chen, B | 1 |
| Schwegler-Berry, D | 2 |
| Teeguarden, JG | 1 |
| Webb-Robertson, BJ | 1 |
| Waters, KM | 1 |
| Varnum, SM | 1 |
| Jacobs, JM | 1 |
| Pounds, JG | 1 |
| Zanger, RC | 1 |
| Roda, E | 1 |
| Coccini, T | 1 |
| Acerbi, D | 1 |
| Barni, S | 1 |
| Vaccarone, R | 1 |
| Manzo, L | 1 |
| Park, EJ | 2 |
| Roh, J | 2 |
| Kim, SN | 2 |
| Kang, MS | 1 |
| Han, YA | 1 |
| Kim, Y | 2 |
| Hong, JT | 2 |
| Choi, K | 1 |
| Kuempel, ED | 2 |
| Ravichandran, P | 1 |
| Baluchamy, S | 1 |
| Gopikrishnan, R | 1 |
| Biradar, S | 1 |
| Ramesh, V | 1 |
| Goornavar, V | 1 |
| Thomas, R | 1 |
| Wilson, BL | 1 |
| Jeffers, R | 1 |
| Hall, JC | 1 |
| Ramesh, GT | 1 |
| Chang, CC | 1 |
| Tsai, ML | 1 |
| Huang, HC | 1 |
| Chen, CY | 1 |
| Dai, SX | 1 |
| Katwa, P | 1 |
| Podila, R | 1 |
| Chen, P | 1 |
| Ke, PC | 1 |
| Rao, AM | 1 |
| Walters, DM | 1 |
| Brown, JM | 1 |
| Ntim, SA | 1 |
| Chung, CH | 1 |
| George, S | 1 |
| Li, N | 1 |
| Mitra, S | 1 |
| Azad, N | 1 |
| Iyer, AK | 1 |
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| Schulte, PA | 1 |
| Zumwalde, RD | 1 |
| Geraci, CL | 1 |
| Hodson, L | 1 |
| Murashov, V | 1 |
| Dahm, MM | 1 |
| Ellenbecker, M | 1 |
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| Duch, MC | 1 |
| Hersam, MC | 1 |
| Swedin, L | 1 |
| Arrighi, R | 1 |
| Andersson-Willman, B | 1 |
| Murray, A | 1 |
| Chen, Y | 1 |
| Karlsson, MC | 1 |
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| Fadeel, B | 1 |
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| Gorelik, O | 1 |
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| Antonini, J | 1 |
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| Ramsey, D | 1 |
| Maynard, A | 1 |
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| McCluskey, R | 1 |
| Hunter, RL | 1 |
12 reviews available for methane and Pulmonary Fibrosis
| Article | Year |
|---|---|
Integration of inflammation, fibrosis, and cancer induced by carbon nanotubes.
Topics: Animals; Humans; Inflammation; Nanotubes, Carbon; Neoplasms; Pulmonary Fibrosis | 2019 |
Signaling Pathways Implicated in Carbon Nanotube-Induced Lung Inflammation.
Topics: Animals; Humans; Lung; Nanotubes, Carbon; Pneumonia; Pulmonary Fibrosis; Signal Transduction | 2020 |
Mechanisms of carbon nanotube-induced pulmonary fibrosis: a physicochemical characteristic perspective.
Topics: Animals; Cells, Cultured; Chemical Phenomena; Disease Models, Animal; Environmental Exposure; Epithe | 2018 |
Type 2 Immune Mechanisms in Carbon Nanotube-Induced Lung Fibrosis.
Topics: Animals; Cell Differentiation; Disease Susceptibility; Humans; Lymphocyte Activation; Macrophage Act | 2018 |
Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP).
Topics: Animals; Cell Communication; Epithelial Cells; Extracellular Matrix Proteins; Fibroblasts; Humans; I | 2016 |
Predicting pulmonary fibrosis in humans after exposure to multi-walled carbon nanotubes (MWCNTs).
Topics: Air Pollutants; Cells, Cultured; Coculture Techniques; Humans; Inhalation Exposure; Nanotubes, Carbo | 2016 |
Myofibroblasts and lung fibrosis induced by carbon nanotube exposure.
Topics: Animals; Humans; Myofibroblasts; Nanotubes, Carbon; Pulmonary Fibrosis | 2016 |
The role of nanotoxicology in realizing the 'helping without harm' paradigm of nanomedicine: lessons from studies of pulmonary effects of single-walled carbon nanotubes.
Topics: Animals; Humans; Inhalation; Lung; Nanomedicine; Nanoparticles; Nanotubes, Carbon; Oxidative Stress; | 2010 |
Carbon nanotubes as delivery systems for respiratory disease: do the dangers outweigh the potential benefits?
Topics: Animals; Disease Progression; Drug Carriers; Humans; Nanotechnology; Nanotubes, Carbon; Neoplasms; P | 2011 |
Focused actions to protect carbon nanotube workers.
Topics: Animals; DNA Damage; Humans; Inhalation Exposure; Lung; Nanotubes, Carbon; Neoplasms; Occupational E | 2012 |
Pulmonary toxicity and fibrogenic response of carbon nanotubes.
Topics: Animals; Blood-Air Barrier; Capillary Permeability; DNA Damage; Humans; Inflammation Mediators; Lung | 2013 |
A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks.
Topics: Air Pollutants; Animals; Environmental Health; Granuloma, Respiratory Tract; Heart; Humans; Inhalati | 2006 |
74 other studies available for methane and Pulmonary Fibrosis
| Article | Year |
|---|---|
Histopathology of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities in a murine model.
Topics: Animals; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Nanofibers; Nanotubes, Carbon; Pulm | 2021 |
Myeloid ABCG1 Deficiency Enhances Apoptosis and Initiates Efferocytosis in Bronchoalveolar Lavage Cells of Murine Multi-Walled Carbon Nanotube-Induced Granuloma Model.
Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily G, Member 1; Bronchoalveolar Lavage; | 2021 |
AOP173 key event associated pathway predictor - online application for the prediction of benchmark dose lower bound (BMDLs) of a transcriptomic pathway involved in MWCNTs-induced lung fibrosis.
Topics: Animals; Benchmarking; Lung; Mice; Nanotubes, Carbon; Pulmonary Fibrosis; Transcriptome | 2022 |
18β-Glycyrrhetinic acid monoglucuronide (GAMG) alleviates single-walled carbon nanotubes (SWCNT)-induced lung inflammation and fibrosis in mice through PI3K/AKT/NF-κB signaling pathway.
Topics: Animals; Collagen; Fibrosis; Glycyrrhetinic Acid; Lung; Mice; Nanotubes, Carbon; NF-kappa B; Phospha | 2022 |
Grouping MWCNTs based on their similar potential to cause pulmonary hazard after inhalation: a case-study.
Topics: Administration, Inhalation; Humans; Lung; Nanotubes, Carbon; Pulmonary Fibrosis; Toxicity Tests | 2022 |
An alternative
Topics: Cell Communication; Humans; Lung; Nanotubes, Carbon; Pulmonary Fibrosis; Respiratory Aerosols and Dr | 2023 |
An alternative
Topics: Cell Communication; Humans; Lung; Nanotubes, Carbon; Pulmonary Fibrosis; Respiratory Aerosols and Dr | 2023 |
An alternative
Topics: Cell Communication; Humans; Lung; Nanotubes, Carbon; Pulmonary Fibrosis; Respiratory Aerosols and Dr | 2023 |
An alternative
Topics: Cell Communication; Humans; Lung; Nanotubes, Carbon; Pulmonary Fibrosis; Respiratory Aerosols and Dr | 2023 |
Characterization and in vivo toxicological evaluation of multi-walled carbon nanotubes: a low-dose repeated intratracheal administration study.
Topics: Animals; Bronchoalveolar Lavage Fluid; Lung; Nanotubes, Carbon; Pulmonary Fibrosis; Time Factors | 2023 |
Impaired autophagy-accelerated senescence of alveolar type II epithelial cells drives pulmonary fibrosis induced by single-walled carbon nanotubes.
Topics: Alveolar Epithelial Cells; Animals; Autophagy; Fibroblasts; Humans; Mice; Nanotubes, Carbon; Pulmona | 2023 |
Effects of inhalation of multi-walled carbon nanotube (MWCNT) on respiratory syncytial virus (RSV) infection in mice.
Topics: Animals; Bronchoalveolar Lavage Fluid; Inhalation Exposure; Lung; Mice; Mice, Inbred C57BL; Nanotube | 2023 |
Role of the protease-activated receptor-2 (PAR2) in the exacerbation of house dust mite-induced murine allergic lung disease by multi-walled carbon nanotubes.
Topics: Allergens; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Fibrosis; Hypersensitivity | 2023 |
SOX2Mediates Carbon Nanotube-Induced Fibrogenesis and Fibroblast Stem Cell Acquisition.
Topics: Animals; Fibroblasts; Lung; Mice; Nanotubes, Carbon; Pulmonary Fibrosis; Stem Cells | 2020 |
Transcriptomics-Based and AOP-Informed Structure-Activity Relationships to Predict Pulmonary Pathology Induced by Multiwalled Carbon Nanotubes.
Topics: Adverse Outcome Pathways; Animals; Lung; Mice; Nanotubes, Carbon; Pulmonary Fibrosis; Structure-Acti | 2021 |
Osteopontin enhances multi-walled carbon nanotube-triggered lung fibrosis by promoting TGF-β1 activation and myofibroblast differentiation.
Topics: Animals; Cell Differentiation; Cells, Cultured; Extracellular Matrix; Extracellular Matrix Proteins; | 2017 |
STAT1-dependent and -independent pulmonary allergic and fibrogenic responses in mice after exposure to tangled versus rod-like multi-walled carbon nanotubes.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Proliferation; Cytokines; Epithelial Cells; Genetic Pred | 2017 |
Stat-6 signaling pathway and not Interleukin-1 mediates multi-walled carbon nanotube-induced lung fibrosis in mice: insights from an adverse outcome pathway framework.
Topics: Adverse Outcome Pathways; Animals; Bronchoalveolar Lavage Fluid; Female; Inhalation Exposure; Interl | 2017 |
Multi-walled carbon nanotube-induced genotoxic, inflammatory and pro-fibrotic responses in mice: Investigating the mechanisms of pulmonary carcinogenesis.
Topics: Animals; Bronchoalveolar Lavage Fluid; Carcinogenesis; Cell Proliferation; Chemical Phenomena; Comet | 2017 |
A 104-week pulmonary toxicity assessment of long and short single-wall carbon nanotubes after a single intratracheal instillation in rats.
Topics: Animals; Bronchi; Comet Assay; DNA Damage; Inhalation Exposure; Lung; Male; Nanotubes, Carbon; Pneum | 2017 |
Macrophage polarization and activation at the interface of multi-walled carbon nanotube-induced pulmonary inflammation and fibrosis.
Topics: Animals; Arginase; Inflammation; Lung; Macrophages; Male; Mice; Nanotubes, Carbon; Nitric Oxide Synt | 2018 |
Carbon nanotubes and crystalline silica induce matrix remodeling and contraction by stimulating myofibroblast transformation in a three-dimensional culture of human pulmonary fibroblasts: role of dimension and rigidity.
Topics: Cells, Cultured; Collagen; Fibroblasts; Humans; Lung; Myofibroblasts; Nanotubes, Carbon; Pulmonary F | 2018 |
Peroxisome Proliferator-activated Receptor-γ Deficiency Exacerbates Fibrotic Response to Mycobacteria Peptide in Murine Sarcoidosis Model.
Topics: Animals; Antigens, Bacterial; Bacterial Proteins; Bronchoalveolar Lavage; Bronchoalveolar Lavage Flu | 2019 |
Role of A
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Cell Differentiation; Cell Survival; Collagen | 2019 |
Substrate Stiffness-Dependent Carbon Nanotube-Induced Lung Fibrogenesis.
Topics: Cell Line; Cell Movement; Collagen Type I; Elasticity; Fibroblasts; Focal Adhesion Protein-Tyrosine | 2019 |
Surface charge and cellular processing of covalently functionalized multiwall carbon nanotubes determine pulmonary toxicity.
Topics: Animals; Biological Transport, Active; Cell Line; Cytokines; Humans; Inflammasomes; Lung; Lung Injur | 2013 |
Multiwall carbon nanotubes mediate macrophage activation and promote pulmonary fibrosis through TGF-β/Smad signaling pathway.
Topics: Animals; Macrophage Activation; Nanotubes, Carbon; Pulmonary Fibrosis; Rats; Rats, Inbred SHR; Signa | 2013 |
Dual acute proinflammatory and antifibrotic pulmonary effects of short palate, lung, and nasal epithelium clone-1 after exposure to carbon nanotubes.
Topics: Animals; Cell Line; Chemotaxis; Glycoproteins; Immunity, Innate; Immunity, Mucosal; Inflammation Med | 2013 |
System-based identification of toxicity pathways associated with multi-walled carbon nanotube-induced pathological responses.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cells, Cultured; Computational Biology; Environmental Polluta | 2013 |
Distribution and fibrotic response following inhalation exposure to multi-walled carbon nanotubes.
Topics: Aerosols; Albumins; Animals; Bronchoalveolar Lavage Fluid; Fibrillar Collagens; Inhalation Exposure; | 2013 |
Towards predicting the lung fibrogenic activity of nanomaterials: experimental validation of an in vitro fibroblast proliferation assay.
Topics: Animals; Asbestos, Crocidolite; BALB 3T3 Cells; Biological Assay; Cell Count; Cell Proliferation; Do | 2013 |
Investigation of the pulmonary bioactivity of double-walled carbon nanotubes.
Topics: Animals; Blood-Air Barrier; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Dose-Response Rela | 2013 |
Long-term effects of carbon containing engineered nanomaterials and asbestos in the lung: one year postexposure comparisons.
Topics: Administration, Inhalation; Animals; Asbestos; Bronchoalveolar Lavage Fluid; Bronchopneumonia; Carbo | 2014 |
Epithelial-mesenchymal transition involved in pulmonary fibrosis induced by multi-walled carbon nanotubes via TGF-beta/Smad signaling pathway.
Topics: Actins; Animals; Antigens, CD; Biomarkers; Cadherins; Cell Line, Tumor; Collagen; Disease Models, An | 2014 |
Effect of fiber length on carbon nanotube-induced fibrogenesis.
Topics: Cell Survival; Cells, Cultured; Collagen Type I; Cytotoxins; Fibroblasts; Humans; Nanotubes, Carbon; | 2014 |
Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts.
Topics: Antioxidants; Apoptosis; Culture Media, Conditioned; Enzyme-Linked Immunosorbent Assay; Epithelial C | 2014 |
Atomic layer deposition coating of carbon nanotubes with aluminum oxide alters pro-fibrogenic cytokine expression by human mononuclear phagocytes in vitro and reduces lung fibrosis in mice in vivo.
Topics: Aluminum Oxide; Animals; Cell Death; Cell Line; Cytokines; Humans; Inflammation; Interleukin-1beta; | 2014 |
Pathologic and molecular profiling of rapid-onset fibrosis and inflammation induced by multi-walled carbon nanotubes.
Topics: Animals; Bronchoalveolar Lavage Fluid; Collagen Type I; Collagen Type I, alpha 1 Chain; Cytokines; F | 2015 |
mRNA and miRNA regulatory networks reflective of multi-walled carbon nanotube-induced lung inflammatory and fibrotic pathologies in mice.
Topics: Animals; Computational Biology; Databases, Genetic; Disease Models, Animal; Gene Expression Profilin | 2015 |
MWCNTs of different physicochemical properties cause similar inflammatory responses, but differences in transcriptional and histological markers of fibrosis in mouse lungs.
Topics: Animals; Bronchoalveolar Lavage Fluid; DNA Damage; Dose-Response Relationship, Drug; Female; Gene Ex | 2015 |
NADPH Oxidase-Dependent NLRP3 Inflammasome Activation and its Important Role in Lung Fibrosis by Multiwalled Carbon Nanotubes.
Topics: Animals; Carrier Proteins; Cathepsin B; Cell Line; Cytochrome b Group; Humans; Inflammasomes; Interl | 2015 |
mRNAs and miRNAs in whole blood associated with lung hyperplasia, fibrosis, and bronchiolo-alveolar adenoma and adenocarcinoma after multi-walled carbon nanotube inhalation exposure in mice.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adenoma; Animals; Gene Regulatory Networks; Hyperplasia; Inh | 2016 |
Alterations in DNA methylation corresponding with lung inflammation and as a biomarker for disease development after MWCNT exposure.
Topics: Animals; Biomarkers; DNA Methylation; Inhalation Exposure; Interferon-gamma; Mice; Nanotubes, Carbon | 2016 |
Towards predicting the lung fibrogenic activity of MWCNT: Key role of endocytosis, kinase receptors and ERK 1/2 signaling.
Topics: Amiloride; Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Collagen; Endocytosis | 2016 |
Identification of TGF-β receptor-1 as a key regulator of carbon nanotube-induced fibrogenesis.
Topics: Animals; Cell Line; Collagen Type I; Fibroblasts; Gene Knockdown Techniques; Humans; Lung; Mice; Nan | 2015 |
Suppression of basal and carbon nanotube-induced oxidative stress, inflammation and fibrosis in mouse lungs by Nrf2.
Topics: Animals; Cytokines; Dose-Response Relationship, Drug; Lung; Macrophages; Mice; Mice, Inbred C57BL; M | 2016 |
Fibrosis biomarkers in workers exposed to MWCNTs.
Topics: Adult; Biomarkers; Cytokines; Female; Humans; Male; Middle Aged; Nanotubes, Carbon; Occupational Exp | 2016 |
Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes.
Topics: Animals; Benchmarking; Computational Biology; Databases, Genetic; Dose-Response Relationship, Drug; | 2016 |
Multiwalled carbon nanotube-induced pulmonary inflammatory and fibrotic responses and genomic changes following aspiration exposure in mice: A 1-year postexposure study.
Topics: Air Pollutants; Animals; Asbestos, Crocidolite; Bronchoalveolar Lavage Fluid; Dose-Response Relation | 2016 |
In vivo activation of a T helper 2-driven innate immune response in lung fibrosis induced by multi-walled carbon nanotubes.
Topics: Acute Disease; Animals; Chronic Disease; Cytokines; Disease Progression; Gene Expression Profiling; | 2016 |
Multi-walled carbon nanotubes directly induce epithelial-mesenchymal transition in human bronchial epithelial cells via the TGF-β-mediated Akt/GSK-3β/SNAIL-1 signalling pathway.
Topics: Animals; Bronchi; Carcinogenicity Tests; Cell Line; Epithelial-Mesenchymal Transition; Glycogen Synt | 2016 |
Atomic layer deposition coating of carbon nanotubes with zinc oxide causes acute phase immune responses in human monocytes in vitro and in mice after pulmonary exposure.
Topics: Acute-Phase Reaction; Air Pollutants; Animals; Cell Line; Cytokines; Disease Progression; Gene Expre | 2016 |
Lung Microtissue Array to Screen the Fibrogenic Potential of Carbon Nanotubes.
Topics: Cell Line; Cell Survival; Cytoprotection; Humans; Lung; MicroRNAs; Models, Biological; Nanotubes, Ca | 2016 |
TIMP1 promotes multi-walled carbon nanotube-induced lung fibrosis by stimulating fibroblast activation and proliferation.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Differentiation; Cell Proliferation; Fibroblasts; Humans | 2017 |
Long-term intravenous administration of carboxylated single-walled carbon nanotubes induces persistent accumulation in the lungs and pulmonary fibrosis via the nuclear factor-kappa B pathway.
Topics: Administration, Intravenous; Animals; Capillaries; Carboxylic Acids; Cytokines; Female; Injections, | 2017 |
Mapping differential cellular protein response of mouse alveolar epithelial cells to multi-walled carbon nanotubes as a function of atomic layer deposition coating.
Topics: Aluminum Oxide; Alveolar Epithelial Cells; Animals; Cells, Cultured; Mice; Nanotubes, Carbon; Proteo | 2017 |
Induction of apoptosis and absence of inflammation in rat lung after intratracheal instillation of multiwalled carbon nanotubes.
Topics: Animals; Apoptosis; Caspase 3; Collagen; Granuloma, Respiratory Tract; Inflammation; Inhalation Expo | 2008 |
Biological effect of carbon graphite whisker in rat lung by long-term Inhalation.
Topics: Adenoma; Air Pollutants; Animals; Body Weight; Epithelial Cells; Graphite; Hyperplasia; Inhalation E | 2009 |
Inhaled carbon nanotubes reach the subpleural tissue in mice.
Topics: Aerosols; Animals; Immunity; Inhalation Exposure; Male; Mice; Mice, Inbred C57BL; Nanotubes, Carbon; | 2009 |
Direct fibrogenic effects of dispersed single-walled carbon nanotubes on human lung fibroblasts.
Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Fibroblasts; Humans; Lung; Mat | 2010 |
Pulmonary toxicity of intratracheally instilled multiwall carbon nanotubes in male Fischer 344 rats.
Topics: Albumins; Alveolar Epithelial Cells; Animals; Body Weight; Bronchoalveolar Lavage Fluid; Disease Mod | 2010 |
Dispersion of single-walled carbon nanotubes by a natural lung surfactant for pulmonary in vitro and in vivo toxicity studies.
Topics: Animals; Biological Products; Cell Proliferation; Cell Survival; Cells, Cultured; Collagen; Epitheli | 2010 |
Comparative proteomics and pulmonary toxicity of instilled single-walled carbon nanotubes, crocidolite asbestos, and ultrafine carbon black in mice.
Topics: Animals; Asbestos, Crocidolite; Bronchoalveolar Lavage Fluid; Chromatography, High Pressure Liquid; | 2011 |
Comparative pulmonary toxicity assessment of pristine and functionalized multi-walled carbon nanotubes intratracheally instilled in rats: morphohistochemical evaluations.
Topics: Administration, Inhalation; Animals; Collagen Type I; Female; Immunohistochemistry; In Situ Nick-End | 2011 |
A single intratracheal instillation of single-walled carbon nanotubes induced early lung fibrosis and subchronic tissue damage in mice.
Topics: Animals; Bronchoalveolar Lavage Fluid; Collagen; Cytokines; Data Interpretation, Statistical; Dose-R | 2011 |
Carbon nanotube risk assessment: implications for exposure and medical monitoring.
Topics: Air Pollutants, Occupational; Animals; Granuloma, Respiratory Tract; Humans; Inhalation Exposure; Na | 2011 |
Pulmonary biocompatibility assessment of inhaled single-wall and multiwall carbon nanotubes in BALB/c mice.
Topics: Aerosols; Animals; Antioxidants; Apoptosis; Caspase 3; Caspase 8; Lung; Materials Testing; Mice; Mic | 2011 |
Epithelial-mesenchymal transition contributes to SWCNT-induced pulmonary fibrosis.
Topics: Animals; beta Catenin; Epithelial-Mesenchymal Transition; Female; Flow Cytometry; Lung; Matrix Metal | 2012 |
Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes.
Topics: Administration, Inhalation; Animals; Dose-Response Relationship, Drug; Granuloma; Lung; Male; Mice; | 2011 |
Multi-walled carbon nanotube instillation impairs pulmonary function in C57BL/6 mice.
Topics: Animals; Bronchoalveolar Lavage Fluid; Collagen; Cytokines; Dose-Response Relationship, Drug; Inhala | 2011 |
Dispersal state of multiwalled carbon nanotubes elicits profibrogenic cellular responses that correlate with fibrogenesis biomarkers and fibrosis in the murine lung.
Topics: Animals; Biomarkers; Cytokines; Dose-Response Relationship, Drug; Lung; Mice; Nanotubes, Carbon; Pul | 2011 |
Reactive oxygen species-mediated p38 MAPK regulates carbon nanotube-induced fibrogenic and angiogenic responses.
Topics: Cell Line; Cell Proliferation; Collagen; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme | 2013 |
CCR5 plays an important role in resolving an inflammatory response to single-walled carbon nanotubes.
Topics: Animals; Apoptosis; Bronchoalveolar Lavage; Caspase 3; Cell Cycle; Immunoglobulin E; Inflammation; I | 2013 |
Pluronic F108 coating decreases the lung fibrosis potential of multiwall carbon nanotubes by reducing lysosomal injury.
Topics: Administration, Inhalation; Animals; Coated Materials, Biocompatible; Lysosomes; Mice; Nanotubes, Ca | 2012 |
Pulmonary exposure to single-walled carbon nanotubes does not affect the early immune response against Toxoplasma gondii.
Topics: Animals; Bronchoalveolar Lavage Fluid; Immunity, Cellular; Intubation, Intratracheal; Lung; Mice; Mi | 2012 |
Functionalized single-walled carbon nanotubes cause reversible acute lung injury and induce fibrosis in mice.
Topics: Acute Lung Injury; Adrenal Cortex Hormones; Animals; Bronchoalveolar Lavage Fluid; Cytokines; Dexame | 2013 |
Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Female; gamma-Glutamyltransferase; Glut | 2005 |