methane has been researched along with Malabsorption Syndromes in 19 studies
Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed)
methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).
Malabsorption Syndromes: General term for a group of MALNUTRITION syndromes caused by failure of normal INTESTINAL ABSORPTION of nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a randomized, double-blind, cross-over study, 27 consecutive patients with unexplained, self-reported food hypersensitivity were given 10 g lactulose and 10 g glucose (placebo)." | 9.14 | Carbohydrate intolerance in patients with self-reported food hypersensitivity: comparison of lactulose and glucose. ( Berstad, A; Midtvedt, T; Morken, MH; Norin, E; Valeur, J, 2009) |
| "In a randomized, double-blind, cross-over study, 27 consecutive patients with unexplained, self-reported food hypersensitivity were given 10 g lactulose and 10 g glucose (placebo)." | 5.14 | Carbohydrate intolerance in patients with self-reported food hypersensitivity: comparison of lactulose and glucose. ( Berstad, A; Midtvedt, T; Morken, MH; Norin, E; Valeur, J, 2009) |
| "The measurement of hydrogen-methane breath gases is widely used in gastroenterology to evaluate malabsorption syndromes and bacterial overgrowth." | 4.02 | Hydrogen-methane breath testing results influenced by oral hygiene. ( Erdrich, S; Harnett, JE; Hawrelak, JA; Myers, SP; Tan, ECK, 2021) |
| "The purpose of the present study was to ascertain whether pediatric patients with chronic abdominal pain had concurrent fructose intolerance as determined by a standardized dose breath hydrogen test (BHT), and whether symptoms would improve with a low-fructose diet." | 3.80 | Fructose intolerance/malabsorption and recurrent abdominal pain in children. ( Abdullah, B; Amoroso, PJ; Escobar, MA; Lustig, D; Pflugeisen, BM; Saeed, R; Shamdeen, S; Sherif, D; Tuider, J, 2014) |
| " Overall, 79 (39 %) patients with gastroparesis had evidence of SIBO by LBT: 30 (15 %) had positive H2@90min, 53 (26 %) positive DPHBT, and 6 (3 %) positive breath methane test." | 3.80 | Small intestinal bacterial overgrowth in gastroparesis. ( George, NS; Parkman, HP; Sankineni, A, 2014) |
| " We performed a dose-response study of fructose absorption in healthy subjects to develop a breath test to distinguish normal from abnormal fructose absorption capacity." | 2.73 | Ability of the normal human small intestine to absorb fructose: evaluation by breath testing. ( Anderson, L; Attaluri, A; Rao, SS; Stumbo, P, 2007) |
| "While lactose malabsorption is a well-investigated condition, few epidemiologic data are available for fructose and sorbitol malabsorption." | 1.42 | Carbohydrate Malabsorption and Putative Carbohydrate-Specific Small Intestinal Bacterial Overgrowth: Prevalence and Diagnostic Overlap Observed in an Austrian Outpatient Center. ( Enko, D; Halwachs-Baumann, G; Kimbacher, C; Kriegshäuser, G; Mangge, H; Stolba, R, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.53) | 18.7374 |
| 1990's | 4 (21.05) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 7 (36.84) | 24.3611 |
| 2020's | 3 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Erdrich, S | 1 |
| Tan, ECK | 1 |
| Hawrelak, JA | 1 |
| Myers, SP | 1 |
| Harnett, JE | 1 |
| Hammer, K | 1 |
| Hasanagic, H | 1 |
| Memaran, N | 1 |
| Huber, WD | 1 |
| Hammer, J | 2 |
| Hammer, HF | 1 |
| Fox, MR | 1 |
| Keller, J | 1 |
| Salvatore, S | 1 |
| Basilisco, G | 1 |
| Lopetuso, L | 1 |
| Benninga, M | 1 |
| Borrelli, O | 1 |
| Dumitrascu, D | 1 |
| Hauser, B | 1 |
| Herszenyi, L | 1 |
| Nakov, R | 1 |
| Pohl, D | 1 |
| Thapar, N | 1 |
| Sonyi, M | 1 |
| Berg, LK | 1 |
| Fagerli, E | 1 |
| Martinussen, M | 1 |
| Myhre, AO | 1 |
| Florholmen, J | 1 |
| Goll, R | 1 |
| Escobar, MA | 1 |
| Lustig, D | 1 |
| Pflugeisen, BM | 1 |
| Amoroso, PJ | 1 |
| Sherif, D | 1 |
| Saeed, R | 1 |
| Shamdeen, S | 1 |
| Tuider, J | 1 |
| Abdullah, B | 1 |
| Hanf, S | 1 |
| Bögözi, T | 1 |
| Keiner, R | 1 |
| Frosch, T | 1 |
| Popp, J | 1 |
| Enko, D | 1 |
| Kriegshäuser, G | 1 |
| Kimbacher, C | 1 |
| Stolba, R | 1 |
| Mangge, H | 1 |
| Halwachs-Baumann, G | 1 |
| Andalib, I | 1 |
| Shah, H | 1 |
| Bal, BS | 1 |
| Shope, TR | 1 |
| Finelli, FC | 1 |
| Koch, TR | 1 |
| Valeur, J | 1 |
| Morken, MH | 1 |
| Norin, E | 1 |
| Midtvedt, T | 1 |
| Berstad, A | 1 |
| Knudsen, CD | 1 |
| Di Palma, JA | 1 |
| George, NS | 1 |
| Sankineni, A | 1 |
| Parkman, HP | 1 |
| Mishkin, DS | 1 |
| Mishkin, S | 1 |
| Blank, D | 1 |
| Yalovsky, M | 1 |
| Rao, SS | 1 |
| Attaluri, A | 1 |
| Anderson, L | 1 |
| Stumbo, P | 1 |
| Rumessen, JJ | 1 |
| Nordgaard-Andersen, I | 1 |
| Gudmand-Høyer, E | 1 |
| Corazza, GR | 1 |
| Benati, G | 1 |
| Strocchi, A | 2 |
| Malservisi, S | 1 |
| Gasbarrini, G | 2 |
| Corazza, G | 1 |
| Ellis, CJ | 1 |
| Levitt, MD | 1 |
| Bolin, TD | 1 |
| Genge, JR | 1 |
| Duncombe, VM | 1 |
| Prins, RA | 1 |
| Flourié, B | 1 |
| Leblond, A | 1 |
| Florent, C | 1 |
| Rautureau, M | 1 |
| Bisalli, A | 1 |
| Rambaud, JC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Autonomic Neuropathy, Gastrointestinal Motility, and Inflammation in HIV[NCT02850276] | Early Phase 1 | 76 participants (Actual) | Interventional | 2015-11-30 | Completed | ||
| Colonic Microbial and Clinical Adaptation to Large Doses of Fructose[NCT00775567] | 45 participants (Actual) | Interventional | 2008-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Number of participants with reduction in Small intestinal bacterial overgrowth (SIBO) assessed with breath testing after 8 weeks of treatment.~The hydrogen breath test for the detection of small intestinal bacterial overgrowth (SIBO), obtained by having participants exhale into a plastic bag. the hydrogen content of the samples is measured using a commercially available analyzer." (NCT02850276)
Timeframe: week 8
| Intervention | Participants (Count of Participants) |
|---|---|
| Pyridostigmine | 13 |
Breath Test at week 8 as compared to baseline. Breath test results is the rise in the combined hydrogen and methane during the breath test. (NCT02850276)
Timeframe: baseline and week 8
| Intervention | ppm (Median) | |
|---|---|---|
| Baseline | week 8 | |
| Pyridostigmine | 28 | 14 |
Change in IL-6 plasma level at week 8 as compared to baseline. Plasma interleukin-6 (IL-6), an important inflammatory mediator which predicts mortality in HIV as well as multiple medical co-morbidities, presumably via inflammatory mechanisms. (NCT02850276)
Timeframe: Baseline and week 8
| Intervention | mean florescence intensity (Median) | |
|---|---|---|
| Baseline | Week 8 | |
| Pyridostigmine | 30.5 | 26.5 |
Change in sCD14 level at week 8 as compared to baseline. sCD14 is a marker of macrophage activation commonly used as an indirect measure of translocation (NCT02850276)
Timeframe: Baseline and week 8
| Intervention | mean florescence intensity (Median) | |
|---|---|---|
| Baseline | Week 8 | |
| Pyridostigmine | 2573 | 2095 |
TNFα is a pro-inflammatory cytokine which is induced by components of translocating bacteria. Change in TNFα level at week 8 compared to baseline (NCT02850276)
Timeframe: Baseline and week 8
| Intervention | mean florescence intensity (Median) | |
|---|---|---|
| Baseline | week 8 | |
| Pyridostigmine | 134.0 | 117.5 |
Percent retention of gastric contents on gastric emptying study. GI dysmotility calculated from gastric emptying scintigraphy - measurement of the percent retention of gastric contents at 4 hours. (NCT02850276)
Timeframe: Baseline and week 8
| Intervention | percent retention of gastric contents (Mean) | |
|---|---|---|
| Baseline | week 8 | |
| Pyridostigmine | 3 | 2 |
Medical Outcomes Study (MOS-HIV) quality of life questionnaire. It is a 35 item questionnaire covering 11 dimensions of health including physical functioning, role functioning, pain, social functioning, emotional well-being, energy/fatigue, cognitive functioning, general health, health distress, overall QOL, and health transition. The total scale ranges from 0-100 with a higher score representing better functioning and well-being. (NCT02850276)
Timeframe: Baseline and week 8
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Baseline | Week 8 | |
| Pyridostigmine | 66.1 | 65 |
The gastrointestinal domain domain score of the COMPASS contains 12 items which reflect gastrointestinal symptoms of autonomic function. It is scored on a total scale of 0-28, with higher numbers reflecting worse symptoms. (NCT02850276)
Timeframe: Baseline and week 8
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Baseline | Week 8 | |
| Pyridostigmine | 8 | 8.6 |
1 review available for methane and Malabsorption Syndromes
| Article | Year |
|---|---|
European guideline on indications, performance, and clinical impact of hydrogen and methane breath tests in adult and pediatric patients: European Association for Gastroenterology, Endoscopy and Nutrition, European Society of Neurogastroenterology and Mot
Topics: Adult; Breath Tests; Carbohydrate Metabolism; Child; Consensus; Dietary Carbohydrates; Dysbiosis; En | 2022 |
4 trials available for methane and Malabsorption Syndromes
| Article | Year |
|---|---|
Effect of fructose-reduced diet in patients with irritable bowel syndrome, and its correlation to a standard fructose breath test.
Topics: Adolescent; Adult; Aged; Biomarkers; Breath Tests; Dietary Carbohydrates; Female; Fructose; Humans; | 2013 |
Carbohydrate intolerance in patients with self-reported food hypersensitivity: comparison of lactulose and glucose.
Topics: Adolescent; Adult; Breath Tests; Carbohydrates; Cross-Over Studies; Dinoprostone; Double-Blind Metho | 2009 |
Ability of the normal human small intestine to absorb fructose: evaluation by breath testing.
Topics: Adult; Aged; Air; Breath Tests; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follo | 2007 |
Carbohydrate malabsorption: quantification by methane and hydrogen breath tests.
Topics: Adult; Breath Tests; Female; Humans; Hydrogen; Intestinal Absorption; Lactulose; Malabsorption Syndr | 1994 |
14 other studies available for methane and Malabsorption Syndromes
| Article | Year |
|---|---|
Hydrogen-methane breath testing results influenced by oral hygiene.
Topics: Adolescent; Adult; Aged; Breath Tests; Dysbiosis; Exhalation; Female; Gases; Gastrointestinal Diseas | 2021 |
Relevance of Methane and Carbon Dioxide Evaluation in Breath Tests for Carbohydrate Malabsorption in a Paediatric Cohort.
Topics: Adolescent; Breath Tests; Carbon Dioxide; Child; Fructose; Humans; Hydrogen; Lactose Intolerance; Ma | 2021 |
Fructose intolerance/malabsorption and recurrent abdominal pain in children.
Topics: Abdominal Pain; Adolescent; Breath Tests; Child; Child, Preschool; Dietary Carbohydrates; Female; Fr | 2014 |
Fast and highly sensitive fiber-enhanced Raman spectroscopic monitoring of molecular H2 and CH4 for point-of-care diagnosis of malabsorption disorders in exhaled human breath.
Topics: Bacterial Infections; Breath Tests; Exhalation; Fiber Optic Technology; Humans; Hydrogen; Intestines | 2015 |
Carbohydrate Malabsorption and Putative Carbohydrate-Specific Small Intestinal Bacterial Overgrowth: Prevalence and Diagnostic Overlap Observed in an Austrian Outpatient Center.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Care Facilities; Austria; Blind Loop Syndrome | 2015 |
Breath Hydrogen as a Biomarker for Glucose Malabsorption after Roux-en-Y Gastric Bypass Surgery.
Topics: Adult; Biomarkers; Breath Tests; Carbohydrate Metabolism, Inborn Errors; Female; Gastric Bypass; Hum | 2015 |
Carbohydrate challenge tests: do you need to measure methane?
Topics: Breath Tests; Carbohydrate Metabolism; Female; Humans; Hydrogen; Lactose Intolerance; Malabsorption | 2012 |
Small intestinal bacterial overgrowth in gastroparesis.
Topics: Adult; Biomarkers; Breath Tests; Female; Gastroparesis; Humans; Hydrogen; Intestine, Small; Lactulos | 2014 |
Does the addition of methane determinations increase the yield of hydrogen breath tests for sugar malabsorption?
Topics: Breath Tests; Carbohydrate Metabolism; Humans; Hydrogen; Malabsorption Syndromes; Methane; Reproduci | 2004 |
The possible role of breath methane measurement in detecting carbohydrate malabsorption.
Topics: Adult; Breath Tests; Carbohydrates; Electrolytes; Fasting; Female; Humans; Hydrogen; Lactose; Malabs | 1994 |
Detection of malabsorption of low doses of carbohydrate: accuracy of various breath H2 criteria.
Topics: Adult; Aged; Anti-Bacterial Agents; Breath Tests; Carbohydrate Metabolism; Female; Humans; Hydrogen; | 1993 |
Correlation of hydrogen and methane production to rice carbohydrate malabsorption in Burmese (Myanmar) children.
Topics: Adult; Aging; Anthropometry; Body Height; Breath Tests; Child; Child, Preschool; Colon; Dietary Carb | 1996 |
Methanogenesis in the gastrointestinal tract of ruminants and man.
Topics: Animals; Carbohydrate Metabolism; Cattle; Colon; Ethanol; Euryarchaeota; Fatty Acids, Volatile; Huma | 1979 |
Starch malabsorption and breath gas excretion in healthy humans consuming low- and high-starch diets.
Topics: Adult; Breath Tests; Colon; Dietary Carbohydrates; Feces; Humans; Hydrogen; Ileum; Intestinal Absorp | 1988 |