Page last updated: 2024-10-16

methane and Colitis Gravis

methane has been researched along with Colitis Gravis in 8 studies

Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed)
methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).

Research Excerpts

ExcerptRelevanceReference
" Since there are two gases (hydrogen and methane) measured on lactulose breath testing, we evaluated whether the different gas patterns on lactulose breath testing coincide with diarrhea and constipation symptoms in IBS and IBD."3.72Methane production during lactulose breath test is associated with gastrointestinal disease presentation. ( Chow, EJ; Hasan, A; Kong, Y; Mayer, AG; Park, S; Pimentel, M, 2003)
"Methane is an inert gas and has probably no direct effect in man."2.39[Hydrogen metabolism in the large intestine--physiology and clinical implications]. ( Christl, SU; Kasper, H; Scheppach, W, 1995)
"Fecal samples from 25 subjects with ulcerative colitis and 17 controls were incubated in 4-L containers, and gas release was assessed at intervals over 24 h."1.30Fecal hydrogen sulfide production in ulcerative colitis. ( Ellis, CJ; Furne, JK; Levine, J; Levitt, MD; Springfield, J, 1998)
"Patients with Crohn's disease, ulcerative colitis, and pneumatosis cystoides intestinalis had significantly lower prevalences of methane excretion (13%, 15%, and 11% respectively)."1.27Methane excretion in man--a study of breath, flatus, and faeces. ( Brydon, WG; Eastwood, MA; McKay, LF, 1985)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19902 (25.00)18.7374
1990's3 (37.50)18.2507
2000's1 (12.50)29.6817
2010's1 (12.50)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Zhu, S1
Han, M1
Liu, S1
Fan, L1
Shi, H1
Li, P1
Karpińska, G1
Dobrowolski, JC1
Yinda, CK1
Rector, A1
Zeller, M1
Conceição-Neto, N1
Heylen, E1
Maes, P1
Ghogomu, SM1
Van Ranst, M1
Matthijnssens, J1
Arthanari, SK1
Vanitha, J1
Ganesh, M1
Venkateshwaran, K1
de Lama Caro-Patón, G1
García-Salido, A1
Iglesias-Bouzas, MI1
Guillén, M1
Cañedo-Villaroya, E1
Martínez-Romera, I1
Serrano-González, A1
Casado-Flores, J1
Gale, P2
Chen, X2
Li, H1
Lucero-Prisno, DE1
Abdullah, AS1
Huang, J1
Laurence, C1
Liang, X1
Ma, Z1
Mao, Z1
Ren, R1
Wu, S1
Wang, N1
Wang, P2
Wang, T1
Yan, H1
Zou, Y1
Olsen, KM1
Gabler, NK1
Rademacher, CJ1
Schwartz, KJ1
Schweer, WP1
Gourley, GG1
Patience, JF1
Rauch, JC1
Stokes, RS1
Shike, DW1
Luebbe, KM1
Stalker, LA1
Klopfenstein, TJ1
Funston, RN1
Unger, PA1
Lighaam, LC1
Vermeulen, E1
Kruithof, S1
Makuch, M1
Culver, EL1
van Bruggen, R1
Remmerswaal, EBM1
Ten Berge, IJM1
Emmens, RW1
Niessen, HWM1
Barnes, E1
Wolbink, GJ1
van Ham, SM1
Rispens, T1
Liang, JX1
Lin, J1
Liu, J1
Wang, X1
Zhang, T1
Li, J1
Wu, Y2
Venier, M1
Salamova, A1
Gonçales, VR1
Lian, J1
Gautam, S1
Tilley, RD1
Gooding, JJ1
Kandel, YR1
Bradley, CA1
Chilvers, MI1
Mathew, FM1
Tenuta, AU1
Smith, DL1
Wise, KA1
Mueller, DS1
Lu, N1
Lu, M1
Liu, P1
Xu, H1
Qiu, X1
Hu, S1
Bai, S1
Wu, J1
Xue, S1
Dai, X1
Dharmage, SC1
Abramson, MJ1
Erbas, B1
Bennett, CM1
Svanes, C1
Hui, J1
Axelrad, C1
Lowe, AJ1
Lodge, CJ1
Hoshi, M1
Osawa, Y1
Nakamoto, K1
Morita, N1
Yamamoto, Y1
Ando, T1
Tashita, C1
Nabeshima, T1
Saito, K1
Gianesello, L1
Del Prete, D1
Ceol, M1
Priante, G1
Calò, LA1
Anglani, F1
Vekaria, HJ1
Hubbard, WB1
Scholpa, NE1
Spry, ML1
Gooch, JL1
Prince, SJ1
Schnellmann, RG1
Sullivan, PG1
Zhang, Q1
Hu, R1
Gu, Z1
Zhang, M1
Zhang, Z1
Peng, Y1
Feng, L1
Li, X3
Zhao, C1
Sarfaraz, K1
Gao, L1
Wang, H1
Wan, C1
Leng, J1
Yang, P1
Gao, X1
Gao, J1
Emam, HE1
Saad, NM1
Abdallah, AEM1
Ahmed, HB1
Palombo, M1
Ianus, A1
Guerreri, M1
Nunes, D1
Alexander, DC1
Shemesh, N1
Zhang, H1
Xiong, Q1
Liu, YS1
Hu, LX1
Shi, ZQ1
Ying, GG1
Chen, R1
Hong, X1
Yan, S1
Zha, J1
Gu, H1
Zhong, Q1
Zeng, Y1
Zhang, S1
Bu, Y1
Farghali, M1
Mayumi, M1
Syo, K1
Satoshi, A1
Seiichi, Y1
Takashima, S1
Ono, H1
Ap, Y1
Yamashiro, T1
Ahmed, MM1
Kotb, S1
Iwasaki, M1
Ihara, I1
Umetsu, K1
Hu, B1
Wang, Y2
Quan, J1
Huang, K1
Gu, X1
Zhu, J1
Yan, Y1
Wu, P1
Yang, L1
Zhao, J1
Koók, L1
Nemestóthy, N1
Bélafi-Bakó, K1
Bakonyi, P1
Luo, X1
Zhang, F1
Li, Q1
Xia, Q1
Li, Z1
Ye, W1
Li, S1
Ge, C1
Zakkula, A1
Pulipati, S1
Dittakavi, S1
Bestha, RM1
Zainuddin, M1
Trivedi, RK1
Mullangi, R1
Lo, GH1
Lin, CW1
Tai, CM1
Perng, DS1
Chen, IL1
Yeh, JH1
Lin, HC1
Rocha, GS1
Silva, MKL1
Cesarino, I1
Hazzaa, SM1
Abdelaziz, SAM1
Abd Eldaim, MA1
Abdel-Daim, MM1
Elgarawany, GE1
Larsson, P1
Ljuslinder, I1
Öhlund, D1
Myte, R1
Löfgren-Burström, A1
Zingmark, C1
Ling, A1
Edin, S1
Palmqvist, R1
Murthi, P1
Rajaraman, G1
Erwich, JJHM1
Dimitriadis, E1
Yoon, HG1
Oh, D1
Ahn, YC1
Noh, JM1
Pyo, H1
Cho, WK1
Song, YM1
Park, M1
Hwang, NY1
Sun, JM1
Kim, HK1
Zo, JI1
Shim, YM1
Persano, A1
Quaranta, F1
Taurino, A1
Siciliano, PA1
Iannacci, J1
Malekbala, MR1
Soltani, S1
Abdul Rashid, S1
Abdullah, LC1
Rashid, U1
Nehdi, IA1
Choong, TSY1
Teo, SH1
Xu, P1
Yan, F1
Zhao, Y1
Sun, S1
Ying, L1
Quinzi, V1
Caruso, S1
Mummolo, S1
Nota, A1
Angelone, AM1
Mattei, A1
Gatto, R1
Marzo, G1
Xin, W1
Severino, J1
Venkert, A1
Yu, H1
Knorr, D1
Yang, JM1
Carlson, L1
Hicks, R1
De Rosa, I1
Beckmann, NA1
Bitsch, RG1
Schonhoff, M1
Siebenrock, KA1
Schwarze, M1
Jaeger, S1
Pimentel, M1
Mayer, AG1
Park, S1
Chow, EJ1
Hasan, A1
Kong, Y1
Piqué, JM1
Pallarés, M1
Cusó, E1
Vilar-Bonet, J1
Gassull, MA1
Christl, SU1
Scheppach, W1
Kasper, H1
Levine, J2
Furne, JK2
Levitt, MD2
Ellis, CJ1
Springfield, J1
McKay, LF1
Eastwood, MA1
Brydon, WG1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Efficacy and Safety of Single, Daily Oral Doses of SYN-010 Compared to Placebo in Adult Patients With Irritable Bowel Syndrome With Constipation (EASE-DO)[NCT03763175]Phase 259 participants (Actual)Interventional2018-12-24Terminated (stopped due to Interim Futility Analysis)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Baseline in Breath Methane Production Based on a Single-point Breath Methane Test

Change in exhaled methane level as a potential predictor of constipation improvement will be evaluated by comparing single-point breath tests pre- and post-treatment. (NCT03763175)
Timeframe: After completing course of SYN-010

Interventionparticles per million (Mean)
SYN-010 21 mg-22.623
SYN-010 42 mg-4.785
Placebo-10.081

Change From Baseline in the Weekly Average Number of Completely Spontaneous Bowel Movements (CSBM) Compared to the 12-week Treatment Period

Subjects will record their daily bowel movements throughout the duration of the study. Change in weekly average number of CSBMs will be evaluated by comparing reported values pre- and post-treatment. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010

InterventionWeekly average CSBMs (Least Squares Mean)
SYN-010 21 mg1.53
SYN-010 42 mg0.32
Placebo0.51

Mean Change From Baseline in the Area-under-the-curve (AUC) of Breath Methane Production, Based on the 120-minute Lactulose Breath Test.

Change in exhaled methane level as a potential predictor of constipation improvement will be evaluated by comparing lactulose breath tests pre- and post-treatment. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010

Interventionparticles per million * min (Mean)
SYN-010 21 mg-18.678
SYN-010 42 mg-20.137
Placebo-39.199

Proportion of Overall Abdominal Pain Intensity Responders During the 12-week Treatment Period

An overall abdominal pain intensity responder is defined as a patient with a weekly abdominal pain intensity response in at least 50% of the weeks of treatment (6 of 12 weeks). A weekly response abdominal pain intensity response is defined as a decrease in the patient's weekly average score for worst abdominal pain in the past 24 hours of at least 30% compared to baseline, with stool frequency unchanged or improved compared with baseline. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010

InterventionParticipants (Count of Participants)
SYN-010 21 mg4
SYN-010 42 mg4
Placebo7

Proportion of Overall Bloating Responders During the 12-week Treatment Period

An overall bloating responder is defined as a patient with a weekly bloating response in at least 50% of the weeks of treatment (6 of 12 weeks). A weekly bloating response is defined as a weekly average bloating score of at least 30% improvement compared to baseline, with stool frequency unchanged or improved compared with baseline. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010

InterventionParticipants (Count of Participants)
SYN-010 21 mg3
SYN-010 42 mg3
Placebo1

Proportion of Overall Responders During the 12-week Treatment Period

An overall 12-week responder is defined as a patient with a weekly response in at least 50% of the weeks of treatment (6 of 12 weeks). A weekly response is defined as a decrease in the patient's weekly average score for worst abdominal pain in the past 24 hours of at least 30% compared to baseline and a stool frequency increase of 1 or more CSBMs per week compared with baseline. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010

InterventionParticipants (Count of Participants)
SYN-010 21 mg1
SYN-010 42 mg2
Placebo6

Proportion of Overall Stool Frequency Responders During the 12-week Treatment Period

An overall stool frequency responder is defined as a patient with a weekly stool frequency response in at least 50% of the weeks of treatment (6 of 12 weeks). A weekly stool frequency response is defined as a stool frequency increase of 1 or more CSBMs per week compared with baseline, with abdominal pain unchanged or improved compared with baseline. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010

InterventionParticipants (Count of Participants)
SYN-010 21 mg4
SYN-010 42 mg6
Placebo9

Proportion of Patients Using Rescue Medication

Subjects will record their use of rescue medication throughout the study period. Proportion of patients using rescue medication after completing the 12-week course of treatment will be compared to those reporting usage at baseline screening period. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010

InterventionParticipants (Count of Participants)
SYN-010 21 mg9
SYN-010 42 mg11
Placebo8

Proportion of Patients With Adequate Relief

Outcome will be assessed by evaluating proportion of patients reporting adequate relief pre- and post-treatment on validated questionnaire. (NCT03763175)
Timeframe: After completing 12-week course of SYN-010

InterventionParticipants (Count of Participants)
SYN-010 21 mg1
SYN-010 42 mg2
Placebo6

Reviews

2 reviews available for methane and Colitis Gravis

ArticleYear
    Computational & theoretical chemistry, 2013, Feb-01, Volume: 1005

    Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am

2013
[Hydrogen metabolism in the large intestine--physiology and clinical implications].
    Zeitschrift fur Gastroenterologie, 1995, Volume: 33, Issue:7

    Topics: Colitis, Ulcerative; Colon; Colonic Neoplasms; Fermentation; Flatulence; Gases; Humans; Hydrogen; Me

1995

Trials

1 trial available for methane and Colitis Gravis

ArticleYear
    Computational & theoretical chemistry, 2013, Feb-01, Volume: 1005

    Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am

2013

Other Studies

6 other studies available for methane and Colitis Gravis

ArticleYear
Composition and diverse differences of intestinal microbiota in ulcerative colitis patients.
    Frontiers in cellular and infection microbiology, 2022, Volume: 12

    Topics: Butyrates; Clostridiales; Colitis, Ulcerative; Gastrointestinal Microbiome; Humans; Lactams, Macrocy

2022
Methane production during lactulose breath test is associated with gastrointestinal disease presentation.
    Digestive diseases and sciences, 2003, Volume: 48, Issue:1

    Topics: Breath Tests; Colitis, Ulcerative; Constipation; Crohn Disease; Databases, Factual; Gastrointestinal

2003
Methane production and colon cancer.
    Gastroenterology, 1984, Volume: 87, Issue:3

    Topics: Adolescent; Adult; Aged; Breath Tests; Child; Colitis, Ulcerative; Colonic Neoplasms; Colonic Polyps

1984
Ashkenazi Jews, sulfur gases, and ulcerative colitis.
    Journal of clinical gastroenterology, 1996, Volume: 22, Issue:4

    Topics: Adolescent; Adult; Aged; Breath Tests; Colitis, Ulcerative; Colon; Humans; Hydrogen Sulfide; Jews; M

1996
Fecal hydrogen sulfide production in ulcerative colitis.
    The American journal of gastroenterology, 1998, Volume: 93, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bacteria; Carbon Dioxide; Carbon Monoxide; Chromatograph

1998
Methane excretion in man--a study of breath, flatus, and faeces.
    Gut, 1985, Volume: 26, Issue:1

    Topics: Adolescent; Adult; Aged; Breath Tests; Colitis, Ulcerative; Colon; Crohn Disease; Feces; Female; Gas

1985