methandriol and Hypertension

The antihypertensive activity of nicergoline (Sermion), an adrenolytic and vasodilator drug, was tested in rats when hypertensive vascular disease was induced by administration of methylandrostenediol (MAD). Nicergoline not only counteracted the effect of MAD on the systolic blood pressure of the rats, but it also prevented the appearance of vascular lesions usually induced by this type of experimental hypertension on arterioles of several organs such as heart, kidney and brain and of the pancreatic mesenteric region. When given alone, the drug was well tolerated. Since the drug did not interfere with the modification induced by MAD on the adrenal steroidogenesis, as seen by EM studies of the zona fasciculata of the androgen-treated animals, it is likely that it may have exerted its adrenolytic effect on the peripheral vessels of the MAD-induced hypertensive rats.

Topics: Adrenal Glands; Androstenediols; Animals; Blood Pressure; Cytochrome P-450 Enzyme System; Ergolines; Female; Hypertension; Methandriol; Nicergoline; Organ Size; Potassium; Rats; Sodium

Adrenal vein catheterizations were done in rats made hypertensive by administration of methylandrostenediol (MAD; 17alpha-methyl-5-androstene-3beta,-17beta-diol), and in control rats at intervals during treatment. All MAD-treated rats were hypertensive by 7 weeks. Secretion of corticosterone was consistently decreased at all times in MAD-treated rats. 18-Hydroxy-11-deoxycorticosterone secretion and 11-deoxycorticosterone (DOC) secretion decreased and increased, respectively, compared to controls at 2, 4, and 6 weeks. Aldosterone secretion was decreased at 2 and 4 weeks. This study shows an in vivo block of adrenal 11- and 18-hydroxylation. Transient DOC accumulation by treatment with MAD produced hypertension, though DOC oversecretion and other changes in steroidogenesis were waning by the time hypertension developed.

Topics: 18-Hydroxydesoxycorticosterone; Adrenal Glands; Animals; Blood Pressure; Body Weight; Corticosterone; Cortodoxone; Female; Hypertension; Methandriol; Rats; Steroids

Topics: Adrenal Glands; Androgens; Animals; Hypertension; Methandriol; Peptide Hydrolases; Rats; Renin

Topics: Androgens; Animals; Blood Vessels; Desoxycorticosterone; Desoxycorticosterone Acetate; Hypertension; Methandriol; Rats

Topics: Androgens; Animals; Hypertension; Methandriol; Myocarditis; Nephrosclerosis; Rats

Topics: Androgens; Animals; Desoxycorticosterone; Hypertension; Kidney; Methandriol; Myocardium; Nephrosclerosis; Rats