methandriol and Coronary-Disease

The effect of seven different anabolic steroids (Ethyloestrenol, Methenolone acetate, Norethandrolone, Methylandrostenediol, Oxymetholone, Methandienone, and Stanozolol) on three alpha-globulin antiprotease inhibitors of thrombin and plasmin was studied in men with ischaemic heart disease. In distinct contrast to the oral contraceptives, five of the six 17-alpha-alkylated anabolic steroids studied produced increased plasma Antithrombin III levels and five produced decreased levels of plasma alpha2-macroglobulin. The effect on plasma alpha1-antitrypsin levels was less clear-cut but three of the steroids examined produced significantly elevated levels. The increased plasma fibrinolytic activity which the 17-alpha-alkylated anabolic steroids induce is therefore unlikely to be secondary to disseminated intravascular coagulation.

Topics: Adult; Aged; alpha 1-Antitrypsin; alpha-Macroglobulins; Anabolic Agents; Antithrombins; Clinical Trials as Topic; Coronary Disease; Disseminated Intravascular Coagulation; Ethylestrenol; Fibrinolysis; Humans; Male; Methandriol; Methandrostenolone; Methenolone; Middle Aged; Norethandrolone; Oxymetholone; Stanozolol