methandriol and Body-Weight

Adrenal vein catheterizations were done in rats made hypertensive by administration of methylandrostenediol (MAD; 17alpha-methyl-5-androstene-3beta,-17beta-diol), and in control rats at intervals during treatment. All MAD-treated rats were hypertensive by 7 weeks. Secretion of corticosterone was consistently decreased at all times in MAD-treated rats. 18-Hydroxy-11-deoxycorticosterone secretion and 11-deoxycorticosterone (DOC) secretion decreased and increased, respectively, compared to controls at 2, 4, and 6 weeks. Aldosterone secretion was decreased at 2 and 4 weeks. This study shows an in vivo block of adrenal 11- and 18-hydroxylation. Transient DOC accumulation by treatment with MAD produced hypertension, though DOC oversecretion and other changes in steroidogenesis were waning by the time hypertension developed.

Topics: 18-Hydroxydesoxycorticosterone; Adrenal Glands; Animals; Blood Pressure; Body Weight; Corticosterone; Cortodoxone; Female; Hypertension; Methandriol; Rats; Steroids

Topics: Adrenal Glands; Androgens; Animals; Body Weight; Body Weights and Measures; Cholesterol; Cortisone; Methandriol; Rats; Thiouracil

Topics: Androgens; Body Weight; Body Weights and Measures; Drug-Related Side Effects and Adverse Reactions; Emetine; Humans; Methandriol; Prednisolone

Topics: Androgens; Body Weight; Body Weights and Measures; Humans; Methandriol; Postoperative Period

Topics: Androgens; Animals; Body Composition; Body Weight; Body Weights and Measures; Methandriol; Rats

Topics: Androgens; Animals; Body Weight; Body Weights and Measures; Methandriol; Muscle Proteins; Muscles; Proteins; Rats