methamphetamine has been researched along with Nerve Degeneration in 71 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (7.04) | 18.7374 |
| 1990's | 9 (12.68) | 18.2507 |
| 2000's | 41 (57.75) | 29.6817 |
| 2010's | 14 (19.72) | 24.3611 |
| 2020's | 2 (2.82) | 2.80 |
| Authors | Studies |
|---|---|
| Ding, J; He, Y; Hu, S; Huang, J; Li, C; Meng, Y; Qiu, P | 1 |
| Aliaghaei, A; Boroujeni, ME; Boroujeni, PB; Fadaeifathabadi, F; Farhadieh, M; Nakhaei, H; Nasrollahi, A; Peirouvi, T; Sajedian, AM; Tehrani, AM | 1 |
| Bae, E; He, Y; Reiner, DJ; Shen, H; Wang, Y; Yu, SJ | 1 |
| Ageta-Ishihara, N; Hattori, S; Kinoshita, M; Miyakawa, T; Morita, T; Takahashi, R; Takao, K; Yamakado, H | 1 |
| Ares-Santos, S; Espadas, I; Granado, N; Martinez-Murillo, R; Moratalla, R | 1 |
| Jang, CG; Kim, HC; Ko, SK; Nabeshima, T; Nah, SY; Nguyen, TT; Park, DH; Shin, EJ; Shin, SW; Wie, MB; Yang, BW | 1 |
| Asanuma, M; Kita, T; Miyazaki, I; Takeshima, M | 1 |
| Chen, CX; Chen, L; Huang, EP; Huang, WY; Liu, C; Qiu, PM; Wang, AF; Wang, HJ; Wu, XF; Xie, WB | 1 |
| Hisahara, S; Honmou, O; Iwahara, N; Kawamata, J; Matsumura, A; Matsushita, T; Sasaki, M; Shimohama, S; Suzuki, S | 1 |
| Aguilera, J; Granado, N; Mendieta, L; Moratalla, R; Tizabi, Y | 1 |
| Bowyer, JF; Hanig, JP; Miller, DB; O'Callaghan, JP; Sarkar, S; Tranter, KM | 1 |
| Emson, PC; Guillot, TS; Li, Y; Miller, GW; Richardson, JR; Shepherd, KR; Wang, MZ | 1 |
| Ferrucci, M; Fornai, F; Paparelli, A; Pasquali, L; Ruggieri, S | 1 |
| Fornai, F; Isidoro, C; Lazzeri, G; Paparelli, A; Pasquali, L; Ruggieri, S | 1 |
| Fu, Y; Fujita, Y; Hirayama, M; Ichihara, M; Ito, M; Kajita, Y; Maesawa, S; Masuda, A; Ohno, K; Ohsawa, I; Ohta, S; Suzuki, Y | 1 |
| Malanga, CJ | 1 |
| Cadet, JL; Cesena, A; Hodges, AB; Hohmann, CF; Ivanova, E; Krasnova, IN; Ladenheim, B; Phillip, CG; Rhoades, R | 1 |
| Cadet, JL; Krasnova, IN | 1 |
| Murphy, NP; Sakoori, K | 1 |
| Chang, WT; Cherng, CG; Chuang, JY; Kao, GS; Yu, L | 1 |
| Luo, Y; Shen, H; Wang, Y; Yu, SJ | 1 |
| Ali, S; Anantharam, V; Chandramani-Shivalingappa, P; Ghosh, A; Jin, H; Kanthasamy, A; Kanthasamy, AG; Lin, M | 1 |
| Kiyatkin, EA; Sharma, HS | 1 |
| Armony, T; Finberg, JP; Gassen, M; Lamensdorf, I; Youdim, MB | 1 |
| Aihara, N; Hida, H; Imamura, N; Ishida, K; Kanda, Y; Nishino, H; Yamada, K | 1 |
| Cadet, JL; Deng, X; Jayanthi, S | 1 |
| Adame, A; Ellis, RJ; Grant, I; Grigorian, A; Langford, D; Marcotte, TD; Masliah, E; McCutchan, JA | 1 |
| Matuszewich, L; Yamamoto, BK | 1 |
| Angulo, JA; Cadet, JL; Wang, J; Yu, J | 1 |
| Marshall, JF; O'Dell, SJ | 3 |
| Adame, A; Crews, L; Grigorian, A; Hurford, R; Langford, D; Masliah, E | 1 |
| Inoue, K; Koizumi, S; Miyatake, M; Narita, M; Shibasaki, M; Suzuki, T; Tsuda, M; Yajima, Y | 1 |
| Brundin, P; Dringen, R; Falsig, J; Leist, M; Lotharius, J; Payne, S; van Beek, J | 1 |
| Cass, WA; Maragos, WF; Theodore, S | 1 |
| Curtis, WR; Palmiter, RD; Perez, FA | 1 |
| Angulo, JA; Xu, W; Zhu, JP | 1 |
| Dluzen, DE; Liu, B | 2 |
| Ali, S; Bowyer, JF | 1 |
| Adame, A; Chana, G; Cherner, M; Crews, L; Ellis, R; Everall, IP; Grant, I; Heaton, R; Langford, D; Lazzaretto, D; Masliah, E | 1 |
| Kalivas, PW; Melendez, RI; Murphy, TH; Pacchioni, AM; Shih, A; Vallone, J | 1 |
| Asanuma, M; Diaz-Corrales, FJ; Higashi, Y; Miyazaki, I; Miyoshi, K; Ogawa, N; Shimizu, M | 1 |
| Belcher, AM; Feinstein, EM; Marshall, JF; O'Dell, SJ | 1 |
| Adame, A; Crews, L; Everall, IP; Grant, I; Kuczenski, R; Masliah, E | 1 |
| Borges, F; Grade, S; Macedo, TR; Marques, E; Milhazes, N; Pereira, FC; Ribeiro, CF; Silva, AP; Simões, PF | 1 |
| Braden, BB; Butler, TR; Prendergast, MA; Self, RL; Smith, KJ | 1 |
| Ali, S; Bowyer, JF; Robinson, B; Schmued, LC | 1 |
| Cadet, JL; Cai, NS | 1 |
| Ricaurte, GA; Schuster, CR; Seiden, LS | 1 |
| Lorez, H | 1 |
| Cappon, GD; Fisher, JE; Pu, C; Vorhees, CV | 1 |
| Bhattacharya, N; Holland, D; Murray, B; Oh, C; Tatton, WG | 1 |
| Ellison, G; Switzer, RC | 1 |
| Althaus, JS; Andrus, PK; Hall, ED; Oostveen, JA; VonVoigtlander, PF | 1 |
| Bowyer, JF; Schmued, LC | 1 |
| Andersen, JK; Jurma, OP; Wei, Q | 1 |
| Albers, DS; Moy, LY; Sonsalla, PK | 1 |
| Carter, RJ; Morton, AJ; Reynolds, DS | 1 |
| Bing, G; Jhoo, W; Kim, H; Shin, E | 1 |
| Harvey, DC; Lacan, G; Melega, WP; Tanious, SP | 1 |
| Ail, SF; Itzhak, Y; Martin, JL | 1 |
| Asanuma, M; Cadet, JL; Hayashi, T; Hirata, H; Ladenheim, B; Su, TP; Tsao, LI | 1 |
| Bonhomme, N; Casara, P; Dorey, G; Lestage, P; Lockhart, B; Roger, A | 1 |
| Davidson, C; Ellinwood, EH; Gow, AJ; Lee, TH | 1 |
| Cadet, JL; Chou, J; Deng, X; Wang, Y | 1 |
| Da Prada, M; Lorez, H; Richards, JG; Saner, A | 1 |
| Black, CK; Schmidt, CJ; Taylor, VL | 1 |
| Gibb, JW; Hanson, GR; Johnson, M | 1 |
| DeLanney, LE; Forno, LS; Irwin, I; Langston, E; Langston, JW; Ricaurte, GA | 1 |
6 review(s) available for methamphetamine and Nerve Degeneration
| Article | Year |
|---|---|
Protective effects of phytochemical antioxidants against neurotoxin-induced degeneration of dopaminergic neurons.
Topics: Animals; Antioxidants; Catechin; Cyclooxygenase 2; Dopamine; Dopaminergic Neurons; Flavonoids; Humans; Methamphetamine; Microglia; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Phytochemicals; Polyphenols; Reactive Oxygen Species | 2014 |
Molecular bases of methamphetamine-induced neurodegeneration.
Topics: Animals; Brain; Central Nervous System Stimulants; Humans; Methamphetamine; Nerve Degeneration; Neurons; Oxidative Stress | 2009 |
Environmental conditions modulate neurotoxic effects of psychomotor stimulant drugs of abuse.
Topics: Animals; Blood-Brain Barrier; Body Temperature; Brain; Brain Edema; Environment; Fever; Hot Temperature; Illicit Drugs; Interpersonal Relations; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Neuroglia | 2012 |
Speed kills: cellular and molecular bases of methamphetamine-induced nerve terminal degeneration and neuronal apoptosis.
Topics: Animals; Apoptosis; Cytoprotection; Humans; Methamphetamine; Mice; Models, Biological; Nerve Degeneration; Neurons; Neurotoxicity Syndromes; Presynaptic Terminals; Rats; Signal Transduction | 2003 |
Methamphetamine-induced neural and cognitive changes in rodents.
Topics: Amphetamine-Related Disorders; Animals; Central Nervous System Stimulants; Cerebral Cortex; Cognition; Cognition Disorders; Cortical Synchronization; Dopamine; Female; Humans; Male; Methamphetamine; Nerve Degeneration; Neurons; Rats; Serotonin | 2007 |
Methamphetamine neurotoxicity: necrotic and apoptotic mechanisms and relevance to human abuse and treatment.
Topics: Amphetamine-Related Disorders; Animals; Apoptosis; Central Nervous System; Disease Models, Animal; Drug Administration Schedule; Humans; Methamphetamine; Necrosis; Nerve Degeneration; Neurotoxins; Parkinson Disease | 2001 |
65 other study(ies) available for methamphetamine and Nerve Degeneration
| Article | Year |
|---|---|
Alpha-Synuclein deficiency ameliorates chronic methamphetamine induced neurodegeneration in mice.
Topics: alpha-Synuclein; Animals; Autophagy; Axons; Cells, Cultured; Cyclin-Dependent Kinase 5; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Hippocampus; Lysosomes; Male; Methamphetamine; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Nerve Degeneration; Neurons; Neurotoxicity Syndromes; Phosphorylation; Substantia Nigra; tau Proteins; Time Factors | 2020 |
Exposure to methamphetamine exacerbates motor activities and alters circular RNA profile of cerebellum.
Topics: Animals; Central Nervous System Stimulants; Cerebellum; Gene Expression; Male; Methamphetamine; Motor Activity; Nerve Degeneration; Purkinje Cells; Rats, Sprague-Dawley; RNA, Circular | 2020 |
9-Cis retinoic acid protects against methamphetamine-induced neurotoxicity in nigrostriatal dopamine neurons.
Topics: Alitretinoin; Animals; Bone Morphogenetic Protein 7; Carrier Proteins; Cells, Cultured; Corpus Striatum; Dopaminergic Neurons; Male; Methamphetamine; Motor Activity; Nerve Degeneration; Neuroprotective Agents; Neurotoxicity Syndromes; Nuclear Receptor Subfamily 4, Group A, Member 1; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substantia Nigra; Tretinoin; Tyrosine 3-Monooxygenase | 2014 |
Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice.
Topics: alpha-Synuclein; Animals; Behavior, Animal; Circadian Rhythm; Dopamine; Dopamine Plasma Membrane Transport Proteins; Exploratory Behavior; Humans; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neostriatum; Nerve Degeneration; Parkinson Disease; Peptides; Protein Structure, Quaternary; Rats; Septins; Solubility; Substrate Specificity; Tyrosine 3-Monooxygenase; Ubiquitin-Protein Ligases | 2013 |
Methamphetamine causes degeneration of dopamine cell bodies and terminals of the nigrostriatal pathway evidenced by silver staining.
Topics: Animals; Apoptosis; Axons; Corpus Striatum; Dopamine Agents; Dopaminergic Neurons; Dose-Response Relationship, Drug; Immunohistochemistry; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Necrosis; Nerve Degeneration; Neural Pathways; Neurons; Silver Staining; Substantia Nigra; Tyrosine 3-Monooxygenase | 2014 |
Ginsenoside Re rescues methamphetamine-induced oxidative damage, mitochondrial dysfunction, microglial activation, and dopaminergic degeneration by inhibiting the protein kinase Cδ gene.
Topics: Animals; Dopaminergic Neurons; Ginsenosides; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Mitochondria; Nerve Degeneration; Oxidative Stress; Protein Kinase C-delta; Protein Kinase Inhibitors | 2014 |
S-Nitrosylating protein disulphide isomerase mediates α-synuclein aggregation caused by methamphetamine exposure in PC12 cells.
Topics: alpha-Synuclein; Animals; Apoptosis; Cell Survival; Central Nervous System Stimulants; Enzyme Inhibitors; Gene Knockdown Techniques; Methamphetamine; Nerve Degeneration; Neurons; Neurotoxicity Syndromes; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; PC12 Cells; Protein Disulfide-Isomerases; Protein Processing, Post-Translational; Rats; RNA Interference; Time Factors; Transfection | 2014 |
Intravenous mesenchymal stem cell administration exhibits therapeutic effects against 6-hydroxydopamine-induced dopaminergic neurodegeneration and glial activation in rats.
Topics: Animals; Dopaminergic Neurons; Female; Humans; Mesenchymal Stem Cell Transplantation; Methamphetamine; Nerve Degeneration; Neuroglia; Oxidopamine; Parkinsonian Disorders; Rats, Sprague-Dawley; Stereotyped Behavior; Substantia Nigra; Tyrosine 3-Monooxygenase | 2015 |
Fragment C Domain of Tetanus Toxin Mitigates Methamphetamine Neurotoxicity and Its Motor Consequences in Mice.
Topics: Animals; Body Temperature; Cell Count; Corpus Striatum; Dopaminergic Neurons; Locomotion; Male; Methamphetamine; Mice; Nerve Degeneration; Neuroprotective Agents; Neurotoxicity Syndromes; Peptide Fragments; Rotarod Performance Test; Tetanus Toxin; Tyrosine 3-Monooxygenase | 2016 |
Vascular-directed responses of microglia produced by methamphetamine exposure: indirect evidence that microglia are involved in vascular repair?
Topics: Animals; Antigens, Surface; Blood Vessels; Calcium-Binding Proteins; CD11b Antigen; Central Nervous System Stimulants; Male; Membrane Glycoproteins; Methamphetamine; Microfilament Proteins; Microglia; Nerve Degeneration; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley | 2016 |
Reduced vesicular storage of dopamine exacerbates methamphetamine-induced neurodegeneration and astrogliosis.
Topics: Amphetamine-Related Disorders; Animals; Astrocytes; Biomarkers; Brain; Cell Compartmentation; Cells, Cultured; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Down-Regulation; Fever; Gliosis; Methamphetamine; Mice; Mice, Knockout; Nerve Degeneration; Neurons; Oxidative Stress; Synaptic Vesicles; Vesicular Monoamine Transport Proteins | 2008 |
Pathways of methamphetamine toxicity.
Topics: Amyotrophic Lateral Sclerosis; Animals; Autophagy; Dopamine; Dopamine Agents; Humans; Methamphetamine; Mice; Mice, Transgenic; Nerve Degeneration; Neurons; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Ubiquitin | 2008 |
Role of autophagy during methamphetamine neurotoxicity.
Topics: Animals; Autophagy; Dopamine; Dopamine Agents; Humans; Methamphetamine; Nerve Degeneration; Neurons; PC12 Cells; Rats; Substantia Nigra | 2008 |
Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease.
Topics: Administration, Oral; Adrenergic Agents; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Hydrogen; Immunohistochemistry; Injections, Intraperitoneal; Male; Methamphetamine; Microinjections; Nerve Degeneration; Neurons; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase | 2009 |
Still no time for complacency: Developmental effects of prenatal methamphetamine exposure.
Topics: Abnormalities, Drug-Induced; Brain; Central Nervous System Stimulants; Child; Child, Preschool; Female; Health Policy; Humans; Infant, Newborn; Magnetic Resonance Imaging; Methamphetamine; Nerve Degeneration; Nerve Fibers, Myelinated; Neuropsychological Tests; Pregnancy; Prenatal Exposure Delayed Effects | 2009 |
Methamphetamine treatment causes delayed decrease in novelty-induced locomotor activity in mice.
Topics: Age Factors; Aging; Amphetamine-Related Disorders; Animals; Brain; Central Nervous System Stimulants; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dopamine; Exploratory Behavior; Male; Methamphetamine; Mice; Mice, Inbred BALB C; Motor Activity; Nerve Degeneration; Presynaptic Terminals | 2009 |
Reduced degeneration of dopaminergic terminals and accentuated astrocyte activation by high dose methamphetamine administration in nociceptin receptor knock out mice.
Topics: Animals; Astrocytes; Calcium-Binding Proteins; Central Nervous System Stimulants; Corpus Striatum; Dopamine; Fever; Glial Fibrillary Acidic Protein; Immunohistochemistry; Male; Methamphetamine; Mice; Mice, Knockout; Microfilament Proteins; Microglia; Nerve Degeneration; Neurons; Nociceptin Receptor; Receptors, Opioid; Tyrosine 3-Monooxygenase | 2010 |
Repeated co-administrations of alcohol- and methamphetamine-produced anxiogenic effect could be associated with the neurotoxicity in the dentate gyrus.
Topics: Adrenergic Uptake Inhibitors; Alcohol-Induced Disorders, Nervous System; Animals; Anxiety Disorders; Central Nervous System Depressants; Dentate Gyrus; Drug Administration Schedule; Drug Combinations; Ethanol; Male; Methamphetamine; Mice; Mice, Inbred BALB C; Nerve Degeneration | 2011 |
Enhanced neurodegeneration after a high dose of methamphetamine in adenosine A3 receptor null mutant mice.
Topics: Adrenergic Uptake Inhibitors; Animals; Down-Regulation; Exploratory Behavior; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Nerve Degeneration; Receptor, Adenosine A3 | 2011 |
Methamphetamine-induced neurotoxicity linked to ubiquitin-proteasome system dysfunction and autophagy-related changes that can be modulated by protein kinase C delta in dopaminergic neuronal cells.
Topics: Animals; Apoptosis; Central Nervous System Stimulants; DNA Fragmentation; Dopaminergic Neurons; Male; Membrane Potential, Mitochondrial; Methamphetamine; Microscopy, Electron, Transmission; Nerve Degeneration; Proteasome Endopeptidase Complex; Protein Kinase C-delta; Rats; Rats, Wistar; RNA, Small Interfering; Signal Transduction; Transfection; Ubiquitin-Protein Ligase Complexes | 2012 |
Attenuation of methamphetamine induced dopaminergic neurotoxicity by flupirtine: microdialysis study on dopamine release and free radical generation.
Topics: Aminopyridines; Animals; Dopamine; Drug Interactions; Extracellular Space; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Microdialysis; Neostriatum; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Presynaptic Terminals; Rats; Rats, Sprague-Dawley | 2003 |
Neurodegeneration of substantia nigra accompanied with macrophage/microglia infiltration after intrastriatal hemorrhage.
Topics: Animals; Apomorphine; Behavior, Animal; Brain-Derived Neurotrophic Factor; Central Nervous System Stimulants; Cerebral Hemorrhage; Collagenases; Disease Models, Animal; Dopamine Agonists; Ectodysplasins; Enzyme-Linked Immunosorbent Assay; Functional Laterality; Immunohistochemistry; In Situ Hybridization; Macrophages; Male; Membrane Proteins; Methamphetamine; Microglia; Mitogen-Activated Protein Kinases; Nerve Degeneration; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; RNA, Messenger; Rotation; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 2003 |
Patterns of selective neuronal damage in methamphetamine-user AIDS patients.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS Dementia Complex; Amphetamine-Related Disorders; Autopsy; Brain; Calbindins; CD4 Lymphocyte Count; Female; HIV Seropositivity; Humans; Longitudinal Studies; Male; Methamphetamine; Nerve Degeneration; Neurons; Parvalbumins; S100 Calcium Binding Protein G; Viral Load | 2003 |
Chronic stress augments the long-term and acute effects of methamphetamine.
Topics: Amphetamine-Related Disorders; Animals; Body Weight; Chronic Disease; Corpus Striatum; Corticosterone; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Down-Regulation; Drug Tolerance; Fever; Male; Methamphetamine; Nerve Degeneration; Neurons; Neurotoxins; Organ Size; Rats; Rats, Sprague-Dawley; Reaction Time; Stress, Physiological | 2004 |
Histological evidence supporting a role for the striatal neurokinin-1 receptor in methamphetamine-induced neurotoxicity in the mouse brain.
Topics: Androstanes; Animals; Benzimidazoles; Brain; Cell Count; Corpus Striatum; Drug Interactions; Fluoresceins; Fluorescent Dyes; Glial Fibrillary Acidic Protein; Immunohistochemistry; Male; Methamphetamine; Mice; Nerve Degeneration; Neurokinin-1 Receptor Antagonists; Neurotoxicity Syndromes; Organic Chemicals; Receptors, Neurokinin-1; Tyrosine 3-Monooxygenase | 2004 |
Neurotoxic regimens of methamphetamine induce persistent expression of phospho-c-Jun in somatosensory cortex and substantia nigra.
Topics: Afferent Pathways; Animals; Apoptosis; Biomarkers; Cell Survival; Denervation; Disease Models, Animal; Down-Regulation; Fluoresceins; Fluorescent Dyes; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Male; Methamphetamine; Nerve Degeneration; Neurotoxins; Organic Chemicals; Phosphorylation; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Substantia Nigra; Time Factors; Vibrissae | 2005 |
The role of mitochondrial alterations in the combined toxic effects of human immunodeficiency virus Tat protein and methamphetamine on calbindin positive-neurons.
Topics: Animals; Brain; Calbindins; Calcium; Cell Death; Cells, Cultured; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Gene Products, tat; HIV; Humans; Immunohistochemistry; Methamphetamine; Microtubule-Associated Proteins; Mitochondria; Nerve Degeneration; Neurons; S100 Calcium Binding Protein G; tat Gene Products, Human Immunodeficiency Virus; Time Factors | 2004 |
Long-lasting change in brain dynamics induced by methamphetamine: enhancement of protein kinase C-dependent astrocytic response and behavioral sensitization.
Topics: Amphetamine-Related Disorders; Animals; Animals, Newborn; Astrocytes; Behavior, Animal; Brain; Cells, Cultured; Central Nervous System Stimulants; Coculture Techniques; Disease Models, Animal; Gyrus Cinguli; Hyperkinesis; Male; Methamphetamine; Mice; Mice, Inbred ICR; Morphine; Narcotics; Nerve Degeneration; Neuronal Plasticity; Nucleus Accumbens; Protein Kinase C; Up-Regulation | 2005 |
Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway.
Topics: Animals; Apoptosis; Carbazoles; Cell Line; Cells, Cultured; Cystine; Cytosol; Dopamine; Enzyme Activation; Ferrous Compounds; Glutathione; Humans; Hydrogen Peroxide; Indoles; JNK Mitogen-Activated Protein Kinases; Lipid Peroxidation; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mesencephalon; Methamphetamine; Nerve Degeneration; Neurites; Neurons; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Superoxides | 2005 |
Methamphetamine and human immunodeficiency virus protein Tat synergize to destroy dopaminergic terminals in the rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biomarkers; Blotting, Western; Central Nervous System Stimulants; Dopamine; Drug Synergism; Gene Products, tat; Male; Methamphetamine; Neostriatum; Nerve Degeneration; Nerve Endings; Nerve Fibers; Oxidative Stress; Rats; Rats, Sprague-Dawley; Silver Staining; Substantia Nigra; Tyrosine 3-Monooxygenase | 2006 |
Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity.
Topics: Aging; Animals; Dopamine; Drug Resistance; Methamphetamine; Mice; Mice, Knockout; Nerve Degeneration; Neurons; Neurotoxins; Oxidative Stress; Oxidopamine; Ubiquitin; Ubiquitin-Protein Ligases | 2005 |
Methamphetamine-induced cell death: selective vulnerability in neuronal subpopulations of the striatum in mice.
Topics: Amphetamine-Related Disorders; Animals; Apoptosis; Biomarkers; Central Nervous System Stimulants; Corpus Striatum; Disease Models, Animal; DNA-Binding Proteins; Drug Resistance; Immunohistochemistry; In Situ Nick-End Labeling; Interneurons; Male; Methamphetamine; Mice; Mice, Inbred ICR; Nerve Degeneration; Nerve Tissue Proteins; Neural Pathways; Neurons; Neurotoxins; Neurotransmitter Agents; Nuclear Proteins | 2006 |
Effect of estrogen upon methamphetamine-induced neurotoxicity within the impaired nigrostriatal dopaminergic system.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Uptake Inhibitors; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Estrogens; Female; Male; Methamphetamine; Mice; Nerve Degeneration; Neural Pathways; Neuroprotective Agents; Neurotoxins; Orchiectomy; Ovariectomy; Parkinsonian Disorders; Substantia Nigra | 2006 |
Effects of estrogen and related agents upon methamphetamine-induced neurotoxicity within an impaired nigrostriatal dopaminergic system of ovariectomized mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Androgens; Animals; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Estradiol; Estrogen Antagonists; Female; Methamphetamine; Mice; Neostriatum; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Ovariectomy; Parkinson Disease; Substantia Nigra; Tamoxifen | 2006 |
High doses of methamphetamine that cause disruption of the blood-brain barrier in limbic regions produce extensive neuronal degeneration in mouse hippocampus.
Topics: Amphetamine-Related Disorders; Amygdala; Animals; Blood-Brain Barrier; Body Temperature; Central Nervous System Stimulants; Cerebral Arteries; Disease Models, Animal; Fever; Fluoresceins; Gliosis; Hippocampus; Immunoglobulin G; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Neurons; Organic Chemicals; Phagocytosis; Plant Lectins; Seizures | 2006 |
Cognitive deficits and degeneration of interneurons in HIV+ methamphetamine users.
Topics: Amphetamine-Related Disorders; Cadaver; Cognition Disorders; Frontal Lobe; HIV Seropositivity; Humans; Interneurons; Memory Disorders; Methamphetamine; Nerve Degeneration; Severity of Illness Index | 2006 |
Nrf2 gene deletion fails to alter psychostimulant-induced behavior or neurotoxicity.
Topics: Amino Acid Transport System y+; Animals; Brain; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Gene Expression Regulation; Glutamic Acid; Methamphetamine; Mice; Mice, Knockout; Nerve Degeneration; NF-E2-Related Factor 2; Nucleus Accumbens; Oxidative Stress; Regulatory Elements, Transcriptional | 2007 |
Suppression of p53-activated gene, PAG608, attenuates methamphetamine-induced neurotoxicity.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Central Nervous System Stimulants; DNA-Binding Proteins; Dopamine; Down-Regulation; Drug Resistance; Gene Expression Regulation; Methamphetamine; Mice; Nerve Degeneration; Neurons; Neurotoxins; Nuclear Proteins; PC12 Cells; Rats; RNA Interference; RNA-Binding Proteins; RNA, Small Interfering; Tumor Suppressor Protein p53 | 2007 |
Escalating dose-multiple binge methamphetamine exposure results in degeneration of the neocortex and limbic system in the rat.
Topics: Animals; Brain; Calbindins; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Administration Schedule; Frontal Lobe; Hippocampus; Interneurons; Limbic System; Male; Methamphetamine; Neocortex; Nerve Degeneration; Neurotoxins; Pyramidal Cells; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G; Time Factors | 2007 |
Methamphetamine induces alterations on hippocampal NMDA and AMPA receptor subunit levels and impairs spatial working memory.
Topics: Animals; Central Nervous System Stimulants; Fluoresceins; Gliosis; Glutamic Acid; Hippocampus; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Methamphetamine; Nerve Degeneration; Organic Chemicals; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Up-Regulation | 2007 |
Potentiation of N-methyl-D-aspartate receptor-mediated neuronal injury during methamphetamine withdrawal in vitro requires co-activation of IP3 receptors.
Topics: Animals; Animals, Newborn; Cell Death; Cell Survival; Central Nervous System Stimulants; Drug Interactions; Drug Synergism; Excitatory Amino Acid Antagonists; Female; Hippocampus; Inositol 1,4,5-Trisphosphate Receptors; Macrocyclic Compounds; Male; Methamphetamine; Nerve Degeneration; Organ Culture Techniques; Oxazoles; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2008 |
Neurotoxic-related changes in tyrosine hydroxylase, microglia, myelin, and the blood-brain barrier in the caudate-putamen from acute methamphetamine exposure.
Topics: Analysis of Variance; Animals; Blood-Brain Barrier; Central Nervous System Stimulants; Corpus Striatum; Disease Models, Animal; Dopamine; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Microglia; Myelin Sheath; Neostriatum; Nerve Degeneration; Serotonin; Time Factors; Tyrosine 3-Monooxygenase | 2008 |
The combination of methamphetamine and of the HIV protein, Tat, induces death of the human neuroblastoma cell line, SH-SY5Y.
Topics: AIDS Dementia Complex; Amphetamine-Related Disorders; Brain; Cell Death; Cell Line, Tumor; Central Nervous System Stimulants; Drug Synergism; Humans; Methamphetamine; Nerve Degeneration; Neuroblastoma; Neurons; tat Gene Products, Human Immunodeficiency Virus; Time Factors | 2008 |
Further evidence that amphetamines produce long-lasting dopamine neurochemical deficits by destroying dopamine nerve fibers.
Topics: Amphetamine; Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Male; Methamphetamine; Nerve Degeneration; Nerve Fibers; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1984 |
Fluorescence histochemistry indicates damage of striatal dopamine nerve terminals in rats after multiple doses of methamphetamine.
Topics: Animals; Brain; Catecholamines; Corpus Striatum; Dopamine; Histocytochemistry; Male; Methamphetamine; Microscopy, Fluorescence; Nerve Degeneration; Nerve Fibers; Neurons; Rats | 1981 |
The effects of amfonelic acid, a dopamine uptake inhibitor, on methamphetamine-induced dopaminergic terminal degeneration and astrocytic response in rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Astrocytes; Chromatography, High Pressure Liquid; Dopamine; Dopamine Uptake Inhibitors; Immunohistochemistry; Male; Methamphetamine; Nalidixic Acid; Naphthyridines; Neostriatum; Nerve Degeneration; Nerve Endings; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase | 1994 |
(-)-Deprenyl alters the survival of adult murine facial motoneurons after axotomy: increases in vulnerable C57BL strain but decreases in motor neuron degeneration mutants.
Topics: Amphetamine; Animals; Axons; Cell Survival; Facial Nerve; Methamphetamine; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mice, Neurologic Mutants; Motor Neurons; Nerve Degeneration; Selegiline; Species Specificity | 1994 |
Dissimilar patterns of degeneration in brain following four different addictive stimulants.
Topics: Animals; Brain; Cocaine; Dextroamphetamine; Disease Models, Animal; Drug Implants; Methamphetamine; Nerve Degeneration; Phencyclidine; Rats; Substance-Related Disorders | 1993 |
Neuroprotective effects of the dopamine D2/D3 agonist pramipexole against postischemic or methamphetamine-induced degeneration of nigrostriatal neurons.
Topics: Animals; Benzothiazoles; Brain Ischemia; Corpus Striatum; Dopamine Agonists; Dose-Response Relationship, Drug; Gerbillinae; Male; Methamphetamine; Nerve Degeneration; Pramipexole; Substantia Nigra; Thiazoles | 1996 |
Methamphetamine exposure can produce neuronal degeneration in mouse hippocampal remnants.
Topics: Animals; Behavior, Animal; Cell Death; Fluorescent Dyes; Hippocampus; Limbic System; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Prosencephalon; Seizures; Silver; Staining and Labeling | 1997 |
Increased expression of monoamine oxidase-B results in enhanced neurite degeneration in methamphetamine-treated PC12 cells.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cell Survival; Dopamine; Dopamine Agents; Hydrogen Peroxide; Lipid Peroxidation; Methamphetamine; Monoamine Oxidase; Nerve Degeneration; Neurites; PC12 Cells; Rats | 1997 |
Lowering ambient or core body temperature elevates striatal MPP+ levels and enhances toxicity to dopamine neurons in MPTP-treated mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine Agents; Excitatory Amino Acid Antagonists; Methamphetamine; Mice; MPTP Poisoning; Nerve Degeneration; Neurons; Neurotoxins; Serotonin Receptor Agonists; Tyrosine 3-Monooxygenase | 1998 |
Dopamine modulates the susceptibility of striatal neurons to 3-nitropropionic acid in the rat model of Huntington's disease.
Topics: Animals; Antihypertensive Agents; Behavior, Animal; Benzazepines; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Antagonists; Drug Interactions; Female; Huntington Disease; Methamphetamine; Microglia; Nerve Degeneration; Neurons; Nitro Compounds; Oxidopamine; Propionates; Rats; Rats, Sprague-Dawley; Substantia Nigra; Sympatholytics; Sympathomimetics | 1998 |
Selenium deficiency potentiates methamphetamine-induced nigral neuronal loss; comparison with MPTP model.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Antioxidants; Diet; Dopamine; Dopamine Agents; Homovanillic Acid; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Selenium; Substantia Nigra; Tyrosine 3-Monooxygenase | 2000 |
Repeated administration of methamphetamine damages cells in the somatosensory cortex: overlap with cytochrome oxidase-rich barrels.
Topics: Animals; Dopamine Uptake Inhibitors; Electron Transport Complex IV; Male; Methamphetamine; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Vibrissae | 2000 |
Recovery from methamphetamine induced long-term nigrostriatal dopaminergic deficits without substantia nigra cell loss.
Topics: Animals; Carbon Radioisotopes; Carrier Proteins; Cell Count; Cercopithecus; Dopamine Plasma Membrane Transport Proteins; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methamphetamine; Neostriatum; Nerve Degeneration; Nerve Tissue Proteins; Neural Pathways; Neuropeptides; Recovery of Function; Substantia Nigra; Time Factors; Tomography, Emission-Computed; Tyrosine 3-Monooxygenase; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2000 |
nNOS inhibitors attenuate methamphetamine-induced dopaminergic neurotoxicity but not hyperthermia in mice.
Topics: Animals; Citrulline; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Fever; Indazoles; Male; Methamphetamine; Mice; Neostriatum; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Nitric Oxide; Nitric Oxide Synthase; Thiourea | 2000 |
Delta opioid peptide [D-Ala2, D-Leu5]enkephalin causes a near complete blockade of the neuronal damage caused by a single high dose of methamphetamine: examining the role of p53.
Topics: Animals; Brain; Carrier Proteins; Central Nervous System Stimulants; Dopamine; Dopamine Plasma Membrane Transport Proteins; Enkephalin, Leucine-2-Alanine; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methamphetamine; Mice; Nerve Degeneration; Nerve Tissue Proteins; Neuroprotective Agents; Serotonin; Transcription, Genetic; Tumor Suppressor Protein p53; Tyrosine 3-Monooxygenase | 2001 |
Protective effect of the antioxidant 6-ethoxy-2,2-pentamethylen-1,2-dihydroquinoline (S 33113) in models of cerebral neurodegeneration.
Topics: Alloxan; Animals; Antioxidants; Body Temperature; Brain Ischemia; Cell Survival; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Hippocampus; Hyperglycemia; Injections, Intraventricular; Kainic Acid; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Nerve Degeneration; Neurons; Quinolines; Rats; Rats, Wistar; Rectum; Survival Rate; tert-Butylhydroperoxide | 2001 |
Methamphetamine causes widespread apoptosis in the mouse brain: evidence from using an improved TUNEL histochemical method.
Topics: Animals; Apoptosis; Brain; Buffers; Central Nervous System Stimulants; Detergents; Endopeptidase K; Hot Temperature; In Situ Nick-End Labeling; Male; Methamphetamine; Mice; Mice, Inbred Strains; Microwaves; Nerve Degeneration; Octoxynol; Rats; Rats, Sprague-Dawley; Reproducibility of Results | 2001 |
Effects of vibrissae removal on methamphetamine-induced damage to rat somatosensory cortical neurons.
Topics: Afferent Pathways; Animals; DNA-Binding Proteins; Early Growth Response Protein 1; Fluoresceins; Fluorescent Dyes; Functional Laterality; Hyperkinesis; Immediate-Early Proteins; Immunohistochemistry; Male; Methamphetamine; Nerve Degeneration; Neurons; Organic Chemicals; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sensory Deprivation; Somatosensory Cortex; Transcription Factors; Transcription, Genetic; Vibrissae | 2002 |
Accumulation of 5-HT in non-terminal axons after p-chloro-N-methylamphetamine without degeneration of identified 5-HT nerve terminals.
Topics: Animals; Axons; Catecholamines; Histocytochemistry; Male; Methamphetamine; Nerve Degeneration; Nerve Endings; Rats; Serotonin | 1976 |
L-DOPA potentiation of the serotonergic deficits due to a single administration of 3,4-methylenedioxymethamphetamine, p-chloroamphetamine or methamphetamine to rats.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Dopamine; Drug Synergism; Fenfluramine; Hippocampus; Levodopa; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Nerve Endings; Nervous System Diseases; p-Chloroamphetamine; Rats; Rats, Inbred Strains; Serotonin | 1991 |
MK-801 attenuates the methamphetamine induced decreased in tryptophan hydroxylase activity.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Anticonvulsants; Brain; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Serotonin; Tryptophan Hydroxylase | 1989 |
Aging and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced degeneration of dopaminergic neurons in the substantia nigra.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Animals; Corpus Striatum; Dopamine; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Nerve Degeneration; Pyridines; Substantia Nigra | 1987 |