methadyl acetate has been researched along with Substance Withdrawal Syndrome in 52 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 37 (71.15) | 18.7374 |
1990's | 5 (9.62) | 18.2507 |
2000's | 9 (17.31) | 29.6817 |
2010's | 1 (1.92) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Gewirtz, JC; Hamilton, KL; Harris, AC | 1 |
Chopra, MP; Feldman, Z; Mancino, MJ; Oliveto, A | 1 |
Baumgart, MI; Schrott, LM; Sparber, SB; Zhang, X | 1 |
Krantz, MJ; Mehler, PS | 1 |
Schrott, LM; Sparber, SB | 1 |
Bochner, F; Newcombe, DA; Somogyi, AA; White, JM | 1 |
France, CP; Koek, W; McMahon, LR; Sell, SL | 1 |
Franklin, L'; Hamilton, KL; Roy, S; Schrott, LM | 1 |
Franklin, L'; Schrott, LM; Serrano, PA | 1 |
Jeziorski, K; Matsumoto, H | 1 |
Baskerville, JC; Brands, B; Gowdey, CW; Hirst, M | 2 |
Goldstein, A; Inturrisi, CE; Judson, BA | 1 |
Geyer, G; Resnick, RB; Washton, AM | 1 |
Dorus, W; Hargreaves, WA; Ling, W; Resnick, R; Senay, E; Tuason, VB | 1 |
Dewey, WL | 1 |
Lichtblau, L; Messing, RB; Sparber, SB | 1 |
Kuwahara, MD; Sparber, SB | 2 |
Ellingboe, J; Goldstein, A; Judson, BA; Mendelson, JH | 1 |
Jones, SE; McGillkiard, KL; Olsen, GD; Robertson, GE | 1 |
Fraser, HF; Gorodetzky, CW; Kay, DC; Yeh, SY | 1 |
Hargreaves, WA; Sorensen, JL; Weinberg, JA | 2 |
Khazan, N; Steinfels, GF; Young, GA | 2 |
Steinfels, GF; Young, GA | 1 |
Lichtblau, L; Sparber, SB | 1 |
Khazan, N; Steinfels, GF; Wolf, DL; Young, GA | 1 |
Goldstein, A; Himmelberger, DU; Judson, BA | 1 |
Gillis, RD; Klett, JC; Ling, W | 1 |
Jasinski, DR; Vaupel, DB | 1 |
Bigelow, GE; Houtsmuller, EJ; Johnson, RE; Schuh, KJ; Stitzer, ML; Walsh, SL | 1 |
Farren, C; Kosten, TR; Oliveto, AH | 1 |
Brandt, MR; France, CP | 1 |
Bigelow, GE; Buchhalter, AR; Eissenberg, T; Stitzer, ML; Walsh, SL | 1 |
Fiellin, DA; O'Connor, PG | 1 |
Goldstein, MG; Sollod, RM | 1 |
Fraser, HF; Isbell, H; Nash, TL; Vanhorn, GD | 1 |
Blaine, JD | 1 |
Klett, CJ | 1 |
Khazan, N; Meltzer, LT; Moreton, JE; Young, GA | 1 |
Dorus, W; Renault, PF; Senay, EC | 1 |
Blaine, J; Renault, P | 1 |
Whysner, JA | 1 |
Goldstein, A | 1 |
Fraser, HF; Isbell, H | 1 |
Fink, M; Freedman, AM; Levine, R; Zaks, A | 1 |
Chen, RC; Ho, AK | 1 |
Hough, G; Murphy, BF; Plumb, M; Taintor, Z | 1 |
Crawford, J; Parwatikar, S; Unverdi, C | 1 |
Crowley, TJ; Macdonald, MJ; Zerbe, G | 1 |
6 review(s) available for methadyl acetate and Substance Withdrawal Syndrome
Article | Year |
---|---|
Treating opioid dependence. Growing implications for primary care.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Buprenorphine; Europe; Humans; Methadone; Methadyl Acetate; Opioid-Related Disorders; Prevalence; Primary Health Care; Substance Withdrawal Syndrome; United States | 2004 |
[Treatment of opiate withdrawal syndromes (historical review)].
Topics: Antipsychotic Agents; Clonidine; Drug Evaluation; History, 19th Century; History, 20th Century; Humans; Methadone; Methadyl Acetate; Morphine; Narcotic Antagonists; Phenothiazines; Substance Withdrawal Syndrome | 1984 |
Possible influence of opioid normetabolites on the onset, magnitude and quality of the opioid abstinence syndrome.
Topics: Administration, Oral; Animals; Biotransformation; Body Weight; Codeine; Dealkylation; Dextropropoxyphene; Dogs; Guinea Pigs; Humans; Injections, Subcutaneous; Levorphanol; Meperidine; Methadyl Acetate; Morphine; Narcotics; Rabbits; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1980 |
Pharmacologic treatment of heroin-dependent patients.
Topics: Analgesics, Opioid; Buprenorphine; Counseling; Heroin Dependence; Humans; Mental Disorders; Methadone; Methadyl Acetate; Naltrexone; Narcotic Antagonists; Physician's Role; Substance Withdrawal Syndrome | 2000 |
Rx: 3x/week LAAM: alternative to methadone. Clinical studies: Phase I.
Topics: Analgesics; Analgesics, Opioid; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Tolerance; Heroin; Heroin Dependence; Humans; Kinetics; Methadone; Methadyl Acetate; Morphine; Morphine Dependence; Patient Dropouts; Substance Withdrawal Syndrome; Time Factors | 1976 |
Introduction. Roc: 3x/week LAAM: alternative to methadone.
Topics: Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Evaluation, Preclinical; Female; Government; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Research Design; Research Support as Topic; Substance Withdrawal Syndrome; United States | 1976 |
15 trial(s) available for methadyl acetate and Substance Withdrawal Syndrome
Article | Year |
---|---|
Evaluation of levo-alpha-acetylmethdol (LAAM) as an alternative treatment for methadone maintenance patients who regularly experience withdrawal: a pharmacokinetic and pharmacodynamic analysis.
Topics: Adult; Analysis of Variance; Cross-Over Studies; Female; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Opioid-Related Disorders; Substance Withdrawal Syndrome | 2004 |
Methadyl acetate (LAAM) in the treatment of heroin addicts. II. Double-blind comparison of gradual and abrupt detoxification.
Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Naltrexone; Outcome and Process Assessment, Health Care; Placebos; Substance Withdrawal Syndrome | 1983 |
Opiate withdrawal using lofexidine, a clonidine analogue with fewer side effects.
Topics: Adult; Ambulatory Care; Antihypertensive Agents; Clinical Trials as Topic; Clonidine; Humans; Male; Methadone; Methadyl Acetate; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1983 |
Alternative induction and crossover schedules for methadyl acetate.
Topics: Adolescent; Adult; Attitude to Health; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Patient Dropouts; Placebos; Random Allocation; Substance Withdrawal Syndrome | 1984 |
Withdrawal from heroin in three or six weeks. Comparison of methadyl acetate and methadone.
Topics: Adult; Ambulatory Care; Follow-Up Studies; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Substance Withdrawal Syndrome | 1982 |
A cooperative clinical study of methadyl acetate. II. Friday-only regimen.
Topics: Adult; Drug Administration Schedule; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Outcome and Process Assessment, Health Care; Substance Withdrawal Syndrome | 1980 |
Dose-response analysis of opioid cross-tolerance and withdrawal suppression during LAAM maintenance.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Female; Humans; Hydromorphone; Male; Methadyl Acetate; Narcotics; Substance Withdrawal Syndrome | 1998 |
Effect of LAAM dose on opiate use in opioid-dependent patients. A pilot study.
Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Male; Methadyl Acetate; Narcotics; Opioid-Related Disorders; Pilot Projects; Substance Withdrawal Syndrome | 1998 |
Relative potency of levo-alpha-acetylmethadol and methadone in humans under acute dosing conditions.
Topics: Adult; Analgesics, Opioid; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Naloxone; Narcotic Antagonists; Pupil; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Surveys and Questionnaires; Time Factors | 1999 |
Rx: 3x/week LAAM: alternative to methadone. Clinical studies: Phase I.
Topics: Analgesics; Analgesics, Opioid; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Tolerance; Heroin; Heroin Dependence; Humans; Kinetics; Methadone; Methadyl Acetate; Morphine; Morphine Dependence; Patient Dropouts; Substance Withdrawal Syndrome; Time Factors | 1976 |
Use of miotic effect in evaluating analgesic drugs in man. 1954 [proceedings].
Topics: Analgesics, Opioid; Clinical Trials as Topic; Euphoria; Humans; Methadyl Acetate; Miotics; Substance Withdrawal Syndrome; Substance-Related Disorders | 1976 |
Early clinical studies of levo-alpha acetylmethadol (LAAM): an opiate for use in the medical treatment of chronic heroin dependence.
Topics: Arousal; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Tolerance; Emotions; Heroin Dependence; Humans; Methadone; Methadyl Acetate; Pain, Intractable; Substance Withdrawal Syndrome | 1978 |
Methadyl acetate and methadone. An open comparison.
Topics: Adult; Clinical Trials as Topic; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Morphine; Substance Withdrawal Syndrome | 1977 |
Introduction. Roc: 3x/week LAAM: alternative to methadone.
Topics: Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Evaluation, Preclinical; Female; Government; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Research Design; Research Support as Topic; Substance Withdrawal Syndrome; United States | 1976 |
Phase III clinical study of levo-alpha-acetylmethadol.
Topics: Clinical Trials as Topic; Drug Evaluation; Drug Interactions; Emotions; Female; Follow-Up Studies; Heroin Dependence; Humans; Illicit Drugs; Male; Methadone; Methadyl Acetate; Pregnancy; Research Design; Self Administration; Substance Withdrawal Syndrome | 1976 |
33 other study(ies) available for methadyl acetate and Substance Withdrawal Syndrome
Article | Year |
---|---|
Affective and neuroendocrine effects of withdrawal from chronic, long-acting opiate administration.
Topics: Affect; Animals; Corticosterone; Male; Methadyl Acetate; Naloxone; Narcotic Antagonists; Narcotics; Neurosecretory Systems; Rats; Rats, Sprague-Dawley; Reflex, Startle; Substance Withdrawal Syndrome | 2013 |
Sex and opioid maintenance dose influence response to naloxone in opioid-dependent humans: a retrospective analysis.
Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Male; Methadone; Methadyl Acetate; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Retrospective Studies; Sex Characteristics; Substance Withdrawal Syndrome | 2008 |
Prenatal opiate withdrawal activates the chick embryo hypothalamic pituitary-adrenal axis and dilates vitelline blood vessels via serotonin(2) receptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chick Embryo; Corticosterone; Disease Models, Animal; Hypothalamo-Hypophyseal System; Methadyl Acetate; Morphogenesis; Naloxone; Narcotics; Pituitary-Adrenal System; Receptors, Serotonin; Ritanserin; Substance Withdrawal Syndrome | 2002 |
Suppressed fever and hypersensitivity responses in chicks prenatally exposed to opiates.
Topics: Analysis of Variance; Animals; Basophils; Chick Embryo; Chickens; Corticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Embryonic Development; Female; Fever; Hypersensitivity; Hypothalamo-Hypophyseal System; Lipopolysaccharides; Methadyl Acetate; Narcotics; Neuroimmunomodulation; Ovum; Skin; Substance Withdrawal Syndrome; Toxicity Tests, Acute; Toxicity Tests, Chronic | 2004 |
Monoaminergic drugs and directly observable signs of LAAM withdrawal in rhesus monkeys.
Topics: Adrenergic alpha-Agonists; Amphetamine; Analgesics, Opioid; Animals; Antidepressive Agents, Tricyclic; Biogenic Monoamines; Clonidine; Cocaine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Haloperidol; Imipramine; Macaca mulatta; Male; Methadyl Acetate; Muscle Rigidity; Naltrexone; Narcotic Antagonists; Respiratory Mechanics; Salivation; Substance Withdrawal Syndrome | 2005 |
Prenatal opiate exposure attenuates LPS-induced fever in adult rats: role of interleukin-1beta.
Topics: Animals; Female; Fever; Hypothalamus; Immune System; Interleukin-1beta; Lipopolysaccharides; Male; Methadyl Acetate; Narcotics; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Spleen; Substance Withdrawal Syndrome | 2007 |
Prenatal opiate exposure impairs radial arm maze performance and reduces levels of BDNF precursor following training.
Topics: Analgesics, Opioid; Animals; Brain-Derived Neurotrophic Factor; Down-Regulation; Drug Administration Schedule; Female; Hippocampus; Learning; Male; Maze Learning; Methadyl Acetate; Neuronal Plasticity; Opioid-Related Disorders; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptor, trkB; Substance Withdrawal Syndrome | 2008 |
Zinc tannate salts of heroin, LAAM and hydromorphone attenuate opiate withdrawal syndrome.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Codeine; Delayed-Action Preparations; Heroin; Humans; Hydromorphone; Male; Methadone; Methadyl Acetate; Opioid-Related Disorders; Rats; Substance Withdrawal Syndrome; Zinc | 1980 |
Various factors which affect the rate of development of tolerance and physical dependence to abused drugs.
Topics: Animals; Body Weight; Drug Tolerance; Humans; Methadone; Methadyl Acetate; Morphine; Naloxone; Rats; Reaction Time; Species Specificity; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1984 |
Neonatal opiate withdrawal alters the reactivity of adult rats to the hot-plate.
Topics: Animals; Dose-Response Relationship, Drug; Escape Reaction; Female; Humans; Male; Methadone; Methadyl Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Reaction Time; Substance Withdrawal Syndrome | 1984 |
Opiate withdrawal increases ornithine decarboxylase activity which is otherwise unaltered in brains of dependent chicken fetuses.
Topics: Animals; Brain; Carboxy-Lyases; Chick Embryo; Humans; Methadone; Methadyl Acetate; Naloxone; Ornithine Decarboxylase; Substance Withdrawal Syndrome | 1983 |
Plasma testosterone and luteinizing hormone levels during levo-alpha-acetylmethadol maintenance and withdrawal.
Topics: Adult; Humans; Luteinizing Hormone; Male; Methadone; Methadyl Acetate; Opioid-Related Disorders; Pituitary Gland; Radioimmunoassay; Substance Withdrawal Syndrome; Testosterone | 1984 |
Altered respiratory control in newborn puppies after chronic prenatal exposure to alpha-1-acetylmethadol (LAAM).
Topics: Animals; Animals, Newborn; Carbon Dioxide; Chloral Hydrate; Dogs; Female; Humans; Methadone; Methadyl Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Respiration; Sleep; Substance Withdrawal Syndrome; Time Factors | 1982 |
Heroin addict responses to six weeks of detoxification with LAAM.
Topics: Adult; Heroin; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Patient Dropouts; Social Adjustment; Substance Withdrawal Syndrome | 1982 |
Narcotic abstinence in dependent rats: EEG and behavioral correlates.
Topics: Animals; Behavior, Animal; Electroencephalography; Female; Humans; Methadone; Methadyl Acetate; Morphine; Opioid-Related Disorders; Rats; Sleep, REM; Substance Withdrawal Syndrome | 1980 |
Effects of narcotic abstinence on schedule-controlled behavior in dependent rats.
Topics: Animals; Conditioning, Operant; Female; Humans; Methadyl Acetate; Morphine; Opioid-Related Disorders; Rats; Reinforcement Schedule; Substance Withdrawal Syndrome; Time Factors | 1981 |
Opiate withdrawal in utero increases neonatal morbidity in the rat.
Topics: Animals; Drug Tolerance; Embryo Implantation; Female; Fetal Death; Humans; Litter Size; Methadone; Methadyl Acetate; Naloxone; Opioid-Related Disorders; Pregnancy; Pregnancy, Animal; Rats; Substance Withdrawal Syndrome | 1981 |
Prenatal withdrawal from opiates interferes with hatching of otherwise viable chick fetuses.
Topics: Animals; Chick Embryo; Humans; Methadone; Methadyl Acetate; Naloxone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1981 |
Morphine challenges in levo-alpha-acetylmethadol (LAAM) post-addict rats.
Topics: Animals; Female; Humans; Methadone; Methadyl Acetate; Morphine; Rats; Sleep; Substance Withdrawal Syndrome; Substance-Related Disorders; Wakefulness | 1981 |
The naloxone test for opiate dependence.
Topics: Humans; Injections, Intramuscular; Injections, Intravenous; Methadyl Acetate; Naloxone; Naltrexone; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1980 |
l-alpha-Acetylmethadol, l-alpha-acetyl-N-normethadol and l-alpha-acetyl-N,N-dinormethadol: comparisons with morphine and methadone in suppression of the opioid withdrawal syndrome in the dog.
Topics: Analgesics, Opioid; Animals; Dogs; Dose-Response Relationship, Drug; Methadone; Methadyl Acetate; Morphine; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1997 |
Chronic l-alpha acetylmethadol in rhesus monkeys: discriminative stimulus and other behavioral measures of dependence and withdrawal.
Topics: Administration, Oral; Animals; Discrimination Learning; Injections, Intravenous; Macaca mulatta; Mental Disorders; Methadyl Acetate; Narcotic Antagonists; Narcotics; Substance Withdrawal Syndrome; Substance-Related Disorders | 1998 |
Dependence in rats after one injection of heroin-, LAAM- or hydromorphone-zinc tannate.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Heroin; Heroin Dependence; Humans; Hydromorphone; Methadone; Methadyl Acetate; Naloxone; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1979 |
The SAODAP cooperative studies of LAAM: unblinded comparison with methadone.
Topics: Drug Administration Schedule; Government Agencies; Heroin Dependence; Humans; Methadone; Methadyl Acetate; Substance Withdrawal Syndrome; United States; United States Food and Drug Administration | 1978 |
1-alpha-acetylmethadol (LAAM), methadone and morphine abstinence in dependent rats: EEG and behavioral correlates.
Topics: Animals; Behavior, Animal; Electroencephalography; Electromyography; Female; Humans; Methadone; Methadyl Acetate; Morphine Dependence; Rats; Sleep, REM; Substance Withdrawal Syndrome; Substance-Related Disorders | 1977 |
Spontaneous vs. naloxone-induced abstinence in dependent rats self-administering L-alpha-acetylmethadol (LAAM) or morphine.
Topics: Animals; Female; Humans; Methadone; Methadyl Acetate; Morphine Dependence; Naloxone; Rats; Self Administration; Sleep, REM; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1979 |
A clinical experience with LAAM.
Topics: Heroin Dependence; Humans; Methadone; Methadyl Acetate; Self Administration; Substance Withdrawal Syndrome; Time Factors | 1976 |
Actions and addiction liabilities of alpha-acetylmethadols in man. 1952 [proceedings].
Topics: Adult; Drug Administration Schedule; Humans; Male; Methadone; Methadyl Acetate; Miotics; Morphine Dependence; Substance Withdrawal Syndrome; Substance-Related Disorders | 1976 |
Levomethadyl acetate: prolonged duration of opioid effects, including cross tolerance to heroin, in man. 1973 [proceedings].
Topics: Adult; Drug Tolerance; Heroin; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Narcotics; Substance Withdrawal Syndrome; Time Factors | 1976 |
Interactions of narcotics, narcotic antagonists, and ethanol during acute, chronic, and withdrawal states.
Topics: Alcohol Drinking; Animals; Animals, Newborn; Dextrorphan; Drug Interactions; Ethanol; Humans; Levorphanol; Male; Methadone; Methadyl Acetate; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1976 |
l-alpha-acetylmethadol and methadone in Buffalo: safety and efficacy.
Topics: Administration, Oral; Adolescent; Adult; Aged; Attitude of Health Personnel; Drug Evaluation; Heroin Dependence; Hostility; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; New York; Patient Compliance; Patient Dropouts; Substance Withdrawal Syndrome | 1975 |
LAAM (l-alpha-acetylmethadol) study in St. Louis.
Topics: Adolescent; Adult; Age Factors; Blood Pressure; Brain; Drug Evaluation; Evoked Potentials; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Missouri; Patient Compliance; Patient Dropouts; Research; Substance Withdrawal Syndrome; Time Factors; Visual Perception | 1975 |
Variability in simian motor and social behavior with alternating-day acetylmethadol.
Topics: Animals; Circadian Rhythm; Humans; Macaca radiata; Male; Methadone; Methadyl Acetate; Motor Activity; Social Behavior; Substance Withdrawal Syndrome; Time Factors | 1985 |