Page last updated: 2024-10-30

methadone and Weight Gain

methadone has been researched along with Weight Gain in 14 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Weight Gain: Increase in BODY WEIGHT over existing weight.

Research Excerpts

ExcerptRelevanceReference
"Methadone maintenance treatment (MMT) is an important treatment tool for the opioid epidemic."6.58Double jeopardy: a review of weight gain and weight management strategies for psychotropic medication prescribing during methadone maintenance treatment. ( Antoine, DG; Huhn, AS; Schlienz, NJ; Speed, TJ; Sweeney, MM, 2018)
"Newborns who are prenatally exposed to methadone are at risk for neonatal abstinence syndrome and the associated excess weight loss and poor weight gain."5.27Randomized Clinical Trial of Standard- Versus High-Calorie Formula for Methadone-Exposed Infants: A Feasibility Study. ( Baker, R; Bogen, DL; Cohlan, B; Hanusa, BH; Medoff-Cooper, B, 2018)
"These analyses corroborate evidence of weight gain with methadone treatment but did not observe a sex-based disparity in weight gain with methadone or buprenorphine treatment for OUD."5.22Sex differences in weight gain during medication-based treatment for opioid use disorder: A meta-analysis and retrospective analysis of clinical trial data. ( Dennis, E; Hu, L; Johnson, A; Kroll, D; Manza, P; McPherson, KL; Tai, B; Volkow, ND, 2022)
" However, data suggest the potential for significant weight gain during methadone treatment and little is known about weight change during buprenorphine treatment."4.31Weight change in a national cohort of U.S. Military Veterans engaged in medication treatment for opioid use disorder. ( Carr, MM; Cave, S; Martino, S; Masheb, R; Midboe, AM; Wolkowicz, NR, 2023)
"Despite the clear efficacy of methadone for opioid dependence, one less desirable phenomenon associated with methadone may be weight gain."3.81Increases in body mass index following initiation of methadone treatment. ( Fenn, JM; Laurent, JS; Sigmon, SC, 2015)
"Besides significant reduction in heroin consumption, weight gain is an accompanying phenomenon during methadone maintenance treatment."3.78[Weight changes of patients in methadone maintenance treatment during four years period]. ( Okruhlica, Ĺ; Slezáková, S, 2012)
"Methadone maintenance treatment (MMT) is an important treatment tool for the opioid epidemic."2.58Double jeopardy: a review of weight gain and weight management strategies for psychotropic medication prescribing during methadone maintenance treatment. ( Antoine, DG; Huhn, AS; Schlienz, NJ; Speed, TJ; Sweeney, MM, 2018)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.14)18.2507
2000's5 (35.71)29.6817
2010's5 (35.71)24.3611
2020's3 (21.43)2.80

Authors

AuthorsStudies
Manza, P1
Kroll, D1
McPherson, KL1
Johnson, A1
Dennis, E1
Hu, L1
Tai, B1
Volkow, ND1
Carr, MM1
Wolkowicz, NR1
Cave, S1
Martino, S1
Masheb, R1
Midboe, AM1
Kaplan, HC1
Kuhnell, P1
Walsh, MC1
Crowley, M1
McClead, R1
Wexelblatt, S1
Ford, S1
Provost, LP1
Lannon, C1
Macaluso, M1
Bogen, DL1
Hanusa, BH1
Baker, R1
Medoff-Cooper, B1
Cohlan, B1
Schlienz, NJ1
Huhn, AS1
Speed, TJ1
Sweeney, MM1
Antoine, DG1
Fenn, JM1
Laurent, JS1
Sigmon, SC2
Okruhlica, L2
Slezáková, S2
Staub, D1
Vargo, MA1
Leveille, TL1
Szpanowska-Wohn, A1
Kolarzyk, E1
Pach, D1
Targosz, D1
Kábrt, J1
Wilczek, H1
Svobodová, J1
Haluzík, M1
Kotrlíková, E1
Robinson, SE1
Wallace, MJ1
Gundersen, R1

Reviews

2 reviews available for methadone and Weight Gain

ArticleYear
Sex differences in weight gain during medication-based treatment for opioid use disorder: A meta-analysis and retrospective analysis of clinical trial data.
    Drug and alcohol dependence, 2022, 09-01, Volume: 238

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Male; Methadone; Opiate Substitution Treatment; O

2022
Double jeopardy: a review of weight gain and weight management strategies for psychotropic medication prescribing during methadone maintenance treatment.
    International review of psychiatry (Abingdon, England), 2018, Volume: 30, Issue:5

    Topics: Body Weight Maintenance; Diagnosis, Dual (Psychiatry); Humans; Methadone; Narcotics; Opiate Substitu

2018

Trials

1 trial available for methadone and Weight Gain

ArticleYear
Randomized Clinical Trial of Standard- Versus High-Calorie Formula for Methadone-Exposed Infants: A Feasibility Study.
    Hospital pediatrics, 2018, Volume: 8, Issue:1

    Topics: Double-Blind Method; Energy Intake; Feasibility Studies; Female; Humans; Infant Formula; Infant, New

2018

Other Studies

11 other studies available for methadone and Weight Gain

ArticleYear
Weight change in a national cohort of U.S. Military Veterans engaged in medication treatment for opioid use disorder.
    Journal of psychiatric research, 2023, Volume: 168

    Topics: Analgesics, Opioid; Buprenorphine; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related

2023
Orchestrated Testing of Formula Type to Reduce Length of Stay in Neonatal Abstinence Syndrome.
    Pediatrics, 2020, Volume: 146, Issue:4

    Topics: Energy Intake; Female; Humans; Infant Formula; Infant, Newborn; Lactose; Length of Stay; Methadone;

2020
Increases in body mass index following initiation of methadone treatment.
    Journal of substance abuse treatment, 2015, Volume: 51

    Topics: Adult; Body Mass Index; Body Weight; Female; Humans; Male; Methadone; Middle Aged; Opiate Substituti

2015
Additive burdens of malnutrition, poverty, and substance abuse.
    Lancet (London, England), 2016, Oct-15, Volume: 388, Issue:10054

    Topics: Analgesics, Opioid; Blood Glucose; Cost of Illness; Feeding Behavior; Health Behavior; Health Promot

2016
[Weight gain among the patients in methadone maintenance program as come-back to population norm].
    Casopis lekaru ceskych, 2008, Volume: 147, Issue:8

    Topics: Adult; Body Mass Index; Female; Humans; Male; Methadone; Narcotics; Opioid-Related Disorders; Weight

2008
Tackling a weighty issue.
    Behavioral healthcare, 2009, Volume: 29, Issue:4

    Topics: Adult; Body Mass Index; Florida; Humans; Methadone; Overweight; Patient Education as Topic; Program

2009
[Weight changes of patients in methadone maintenance treatment during four years period].
    Casopis lekaru ceskych, 2012, Volume: 151, Issue:8

    Topics: Adult; Female; Heroin Dependence; Humans; Male; Methadone; Opiate Substitution Treatment; Weight Gai

2012
[Nutritional status of opiate-dependent persons before and during methadone maintenance therapy].
    Przeglad lekarski, 2004, Volume: 61, Issue:4

    Topics: Adult; Body Composition; Body Mass Index; Body Size; Female; Humans; Male; Methadone; Middle Aged; N

2004
[Nutritional status of drug addicts in a methadone program].
    Casopis lekaru ceskych, 1999, Nov-15, Volume: 138, Issue:22

    Topics: Adult; Anthropometry; Blood Chemical Analysis; Female; Humans; Male; Methadone; Nutritional Status;

1999
Effect of perinatal buprenorphine exposure on development in the rat.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 298, Issue:2

    Topics: Animals; Animals, Newborn; Buprenorphine; Drinking; Eating; Female; Growth; Litter Size; Methadone;

2001
[Methadone and thyroid disorders].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2001, Nov-30, Volume: 121, Issue:29

    Topics: Humans; Hypothyroidism; Methadone; Narcotics; Obesity; Opioid-Related Disorders; Weight Gain

2001