Page last updated: 2024-10-30

methadone and Tuberculosis

methadone has been researched along with Tuberculosis in 20 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Tuberculosis: Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.

Research Excerpts

ExcerptRelevanceReference
"To evaluate an approach to enhancing compliance with tuberculosis chemoprophylaxis in drug users enrolled on methadone maintenance utilizing an isoniazid (INH)-methadone admixture."7.70Tuberculosis chemoprophylaxis using a liquid isoniazid-methadone admixture for drug users in methadone maintenance. ( Durante, AJ; Friedman, L; Henry, S; O'Connor, PG; Selwyn, PA; Shi, JM, 1999)
"The rate of tuberculosis in patients receiving methadone treatment is significantly greater than the general population."7.69Tuberculosis treatment through directly observed therapy in a large multisite methadone maintenance treatment program: addressing the public health needs of a high-risk population. ( Altarac, D; Dansky, SF, 1995)
" This study compared completion rates for isoniazid (INH) preventive therapy for injection drug users (IDUs) randomly assigned to methadone treatment combined with directly observed preventive treatment (DOPT) versus those assigned to routine TB clinic referral without methadone treatment."6.70A controlled trial of methadone treatment combined with directly observed isoniazid for tuberculosis prevention in injection drug users. ( Batki, SL; Bradley, JM; Bradley, M; Delucchi, K; Gruber, VA, 2002)
"Methadone maintenance treatment (MMT) has been available in Guangdong province, China since 2006."5.39High prevalence of HIV, HCV and tuberculosis and associated risk behaviours among new entrants of methadone maintenance treatment clinics in Guangdong Province, China. ( Chen, W; Ling, L; Zhang, D; Zhang, L; Zou, X, 2013)
"Treatment with isoniazid was beneficial in HIV-infected, tuberculin-positive IDUs."5.32Effectiveness of isoniazid treatment for latent tuberculosis infection among human immunodeficiency virus (HIV)-infected and HIV-uninfected injection drug users in methadone programs. ( Amofa, J; Driver, CR; Fujiwara, PI; Gourevitch, MN; Highley, E; Kaye, K; Munsiff, SS; Rubino, MA; Scholten, JN; Seewald, R; Trim, C, 2003)
"Methadone dosing was not contingent upon ingestion of antituberculous medication(s)."5.29Successful adherence to observed prophylaxis and treatment of tuberculosis among drug users in a methadone program. ( Gourevitch, MN; Panero, MS; Selwyn, PA; Wasserman, W, 1996)
"To analyse prevalence of hidden hepatitis B infection (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), and tuberculosis infection in drug users (DU) in a maintenance programme with methadone (MPM)."3.71[Prevalence of chronic hidden infections in a cohort of patients in substitutive treatment with methadone]. ( Belda, J; de Estudio Protocolo-INH, G; Esteban, J; Isabel Manso, M; Llinares, R; Portilla, J; Sánchez-Payá, J, 2001)
"To evaluate an approach to enhancing compliance with tuberculosis chemoprophylaxis in drug users enrolled on methadone maintenance utilizing an isoniazid (INH)-methadone admixture."3.70Tuberculosis chemoprophylaxis using a liquid isoniazid-methadone admixture for drug users in methadone maintenance. ( Durante, AJ; Friedman, L; Henry, S; O'Connor, PG; Selwyn, PA; Shi, JM, 1999)
"The rate of tuberculosis in patients receiving methadone treatment is significantly greater than the general population."3.69Tuberculosis treatment through directly observed therapy in a large multisite methadone maintenance treatment program: addressing the public health needs of a high-risk population. ( Altarac, D; Dansky, SF, 1995)
" This study compared completion rates for isoniazid (INH) preventive therapy for injection drug users (IDUs) randomly assigned to methadone treatment combined with directly observed preventive treatment (DOPT) versus those assigned to routine TB clinic referral without methadone treatment."2.70A controlled trial of methadone treatment combined with directly observed isoniazid for tuberculosis prevention in injection drug users. ( Batki, SL; Bradley, JM; Bradley, M; Delucchi, K; Gruber, VA, 2002)
"Most methadone treatment programs have insufficient resources to provide medical care."2.67Providing medical care to methadone clinic patients: referral vs on-site care. ( Bigelow, GE; Ginn, DH; Pabst, KM; Umbricht-Schneiter, A, 1994)
" The results confirm the importance of adequate OAT dosing (≥60mg of methadone, ≥8mg of buprenorphine)."1.46Retention in medication-assisted treatment programs in Ukraine-Identifying factors contributing to a continuing HIV epidemic. ( Altice, FL; Chernova, O; Dumchev, K; Dvoryak, S; Morozova, O, 2017)
"Methadone maintenance treatment (MMT) has been available in Guangdong province, China since 2006."1.39High prevalence of HIV, HCV and tuberculosis and associated risk behaviours among new entrants of methadone maintenance treatment clinics in Guangdong Province, China. ( Chen, W; Ling, L; Zhang, D; Zhang, L; Zou, X, 2013)
"Treatment with isoniazid was beneficial in HIV-infected, tuberculin-positive IDUs."1.32Effectiveness of isoniazid treatment for latent tuberculosis infection among human immunodeficiency virus (HIV)-infected and HIV-uninfected injection drug users in methadone programs. ( Amofa, J; Driver, CR; Fujiwara, PI; Gourevitch, MN; Highley, E; Kaye, K; Munsiff, SS; Rubino, MA; Scholten, JN; Seewald, R; Trim, C, 2003)
"Methadone dosing was not contingent upon ingestion of antituberculous medication(s)."1.29Successful adherence to observed prophylaxis and treatment of tuberculosis among drug users in a methadone program. ( Gourevitch, MN; Panero, MS; Selwyn, PA; Wasserman, W, 1996)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19902 (10.00)18.7374
1990's6 (30.00)18.2507
2000's5 (25.00)29.6817
2010's6 (30.00)24.3611
2020's1 (5.00)2.80

Authors

AuthorsStudies
Roberts, L1
Dumchev, K1
Dvoryak, S2
Chernova, O1
Morozova, O2
Altice, FL3
Gowing, LR1
Hickman, M1
Degenhardt, L1
Zhang, L1
Zhang, D1
Chen, W1
Zou, X1
Ling, L1
Bruce, RD3
Lambdin, B2
Chang, O1
Masao, F1
Mbwambo, J2
Mteza, I2
Nyandindi, C2
Zamudio-Haas, S1
Buma, D1
Dunbar, MS1
Kilonzo, G1
Gupta, A1
Shenoi, S1
Doula, BI1
Mfaume, S1
Schwarz, RK1
Ball, SA1
Herme, M1
HEROLD, K1
Scholten, JN1
Driver, CR1
Munsiff, SS1
Kaye, K1
Rubino, MA1
Gourevitch, MN2
Trim, C1
Amofa, J1
Seewald, R1
Highley, E1
Fujiwara, PI1
Umbricht-Schneiter, A1
Ginn, DH1
Pabst, KM1
Bigelow, GE1
Sell, L1
Finch, E1
Farrell, M1
Sheridan, J1
Strang, J1
Wasserman, W1
Panero, MS1
Selwyn, PA3
Antela, A1
Casado, JL1
González, MJ1
Pérez, P1
Pérez-Elías, MJ1
Montilla, P1
Buzón, L1
Altarac, D1
Dansky, SF1
O'Connor, PG1
Shi, JM1
Henry, S1
Durante, AJ1
Friedman, L1
Portilla, J1
Esteban, J1
Llinares, R1
Belda, J1
Sánchez-Payá, J1
Isabel Manso, M1
de Estudio Protocolo-INH, G1
Habrat, B1
Chmielewska, K1
Baran-Furga, H1
Batki, SL1
Gruber, VA1
Bradley, JM1
Bradley, M1
Delucchi, K1
Feingold, AR1
Iezza, A1
Satyadeo, M1
Colley, J1
Torres, R1
Shaw, JF1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Continuing Care Following Drug Abuse Treatment: Linkage With Primary Care[NCT01621711]504 participants (Actual)Interventional2011-03-31Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for methadone and Tuberculosis

ArticleYear
Mitigating the risk of HIV infection with opioid substitution treatment.
    Bulletin of the World Health Organization, 2013, Feb-01, Volume: 91, Issue:2

    Topics: Antiretroviral Therapy, Highly Active; Buprenorphine; Comorbidity; Evidence-Based Medicine; Harm Red

2013

Trials

2 trials available for methadone and Tuberculosis

ArticleYear
Providing medical care to methadone clinic patients: referral vs on-site care.
    American journal of public health, 1994, Volume: 84, Issue:2

    Topics: Female; Health Services; HIV Infections; Humans; Hypertension; Male; Methadone; Referral and Consult

1994
A controlled trial of methadone treatment combined with directly observed isoniazid for tuberculosis prevention in injection drug users.
    Drug and alcohol dependence, 2002, May-01, Volume: 66, Issue:3

    Topics: Adult; Analysis of Variance; Antitubercular Agents; Chi-Square Distribution; Directly Observed Thera

2002

Other Studies

17 other studies available for methadone and Tuberculosis

ArticleYear
Surge of HIV, tuberculosis and COVID feared amid war in Ukraine.
    Nature, 2022, Volume: 603, Issue:7902

    Topics: Anti-HIV Agents; Armed Conflicts; COVID-19; HIV Infections; Humans; Immunization Programs; Male; Mea

2022
Retention in medication-assisted treatment programs in Ukraine-Identifying factors contributing to a continuing HIV epidemic.
    The International journal on drug policy, 2017, Volume: 48

    Topics: Adult; Buprenorphine; Cohort Studies; Delivery of Health Care, Integrated; Dose-Response Relationshi

2017
High prevalence of HIV, HCV and tuberculosis and associated risk behaviours among new entrants of methadone maintenance treatment clinics in Guangdong Province, China.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Adult; Analgesics, Opioid; China; Coinfection; Comorbidity; Female; Hepatitis C; HIV Infections; Hum

2013
Lessons from Tanzania on the integration of HIV and tuberculosis treatments into methadone assisted treatment.
    The International journal on drug policy, 2014, Volume: 25, Issue:1

    Topics: Delivery of Health Care, Integrated; HIV Infections; Humans; Mental Health Services; Methadone; Opia

2014
Methadone treatment improves tuberculosis treatment among hospitalized opioid dependent patients in Ukraine.
    The International journal on drug policy, 2013, Volume: 24, Issue:6

    Topics: Adult; Analgesics, Opioid; Antitubercular Agents; Delivery of Health Care, Integrated; Drug Users; F

2013
Active case finding for tuberculosis among people who inject drugs on methadone treatment in Dar es Salaam, Tanzania.
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2014, Volume: 18, Issue:7

    Topics: Adult; Female; Humans; Male; Methadone; Prevalence; Substance Abuse, Intravenous; Surveys and Questi

2014
Comparison of tuberculin skin testing reactivity in opioid-dependent patients seeking treatment with methadone versus buprenorphine: policy implications for tuberculosis screening.
    The American journal of drug and alcohol abuse, 2009, Volume: 35, Issue:6

    Topics: Adult; Buprenorphine; Female; Humans; Male; Methadone; Opioid-Related Disorders; Policy Making; Prev

2009
[Polamidon as cough remedy in treatment of menopausal deficiencies with estrogens].
    Die Medizinische, 1953, Jan-24, Volume: 6, Issue:4

    Topics: Contraceptive Agents, Female; Cough; Estradiol Congeners; Estrogens; Female; Humans; Menopause; Meth

1953
Effectiveness of isoniazid treatment for latent tuberculosis infection among human immunodeficiency virus (HIV)-infected and HIV-uninfected injection drug users in methadone programs.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2003, Dec-15, Volume: 37, Issue:12

    Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Antitubercular Agents; Female; HIV; HIV Infectio

2003
Directly observed treatment for tuberculosis. Could be provided by community pharmacists supervising consumption of methadone.
    BMJ (Clinical research ed.), 1996, Jul-06, Volume: 313, Issue:7048

    Topics: Antitubercular Agents; Community Pharmacy Services; Humans; Methadone; Patient Compliance; Substance

1996
Successful adherence to observed prophylaxis and treatment of tuberculosis among drug users in a methadone program.
    Journal of addictive diseases, 1996, Volume: 15, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antitubercular Agents; Comorbidity; Female; Humans; Male;

1996
Influence of a methadone maintenance programme on the improved outcome of a cohort on injecting drug users with advanced HIV disease.
    AIDS (London, England), 1997, Volume: 11, Issue:11

    Topics: Adult; AIDS-Related Opportunistic Infections; CD4 Lymphocyte Count; Disease Progression; Female; HIV

1997
Tuberculosis treatment through directly observed therapy in a large multisite methadone maintenance treatment program: addressing the public health needs of a high-risk population.
    Journal of public health management and practice : JPHMP, 1995,Fall, Volume: 1, Issue:4

    Topics: Adult; Antitubercular Agents; Community Health Services; Female; Health Services Accessibility; Heal

1995
Tuberculosis chemoprophylaxis using a liquid isoniazid-methadone admixture for drug users in methadone maintenance.
    Addiction (Abingdon, England), 1999, Volume: 94, Issue:7

    Topics: Antitubercular Agents; Cohort Studies; Drug Combinations; Female; Humans; Isoniazid; Male; Methadone

1999
[Prevalence of chronic hidden infections in a cohort of patients in substitutive treatment with methadone].
    Medicina clinica, 2001, Mar-10, Volume: 116, Issue:9

    Topics: Adult; Female; Hepatitis B, Chronic; Hepatitis C, Chronic; HIV Infections; Humans; Male; Methadone;

2001
[Health status of individuals dependent on opiates before and after a year of treatment in a methadone maintenance program].
    Przeglad lekarski, 2001, Volume: 58, Issue:4

    Topics: Adult; Female; Health Status; Humans; Infections; Liver Diseases; Male; Methadone; Opioid-Related Di

2001
Primary care for patients with human immunodeficiency virus (HIV) infection in a methadone maintenance treatment program.
    Annals of internal medicine, 1989, Nov-01, Volume: 111, Issue:9

    Topics: Acquired Immunodeficiency Syndrome; Adult; Aerosols; Female; HIV Infections; Humans; Male; Methadone

1989