methadone has been researched along with Torsade de Pointes in 101 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methadone is highly effective in treating opioid dependence, and it is also used as an analgesic for second-line management of chronic pain." | 8.86 | Methadone deaths: risk factors in pain and addicted populations. ( Brooks, D; Modesto-Lowe, V; Petry, N, 2010) |
| "Methadone is increasingly prescribed for chronic pain, yet the associated mortality appears to be rising disproportionately relative to other opioid analgesics." | 8.85 | Methadone-induced mortality in the treatment of chronic pain: role of QT prolongation. ( Andrews, CM; Capacchione, JF; Haigney, MC; Krantz, MJ; Marcuson, MJ; Wedam, EF, 2009) |
| "To assess the relative frequency of reporting of adverse events involving ventricular arrhythmia, cardiac arrest, corrected QT interval (QTc) prolongation or torsade de pointes to the US Food and Drug Administration (FDA) between buprenorphine and methadone." | 7.81 | Arrhythmia associated with buprenorphine and methadone reported to the Food and Drug Administration. ( Haigney, MC; Kao, DP; Krantz, MJ; Mehler, PS, 2015) |
| "High-dose methadone has been associated with rate-corrected QT (QTc) prolongation and 'torsade de pointes'." | 7.77 | Methadone maintenance, QTc and torsade de pointes: who needs an electrocardiogram and what is the prevalence of QTc prolongation? ( Gossop, M; Lintzeris, N; Markides, V; Mayet, S; Strang, J, 2011) |
| "Methadone, a pharmacological agent used to treat heroin dependence is relatively safe, but may cause cardiac arrhythmias in the concurrent presence of other risk factors." | 7.75 | Itraconazole-induced torsade de pointes in a patient receiving methadone substitution therapy. ( Narayanan, S; NoorZurani, MH; Vicknasingam, B, 2009) |
| "Outpatient pain management center and methadone maintenance treatment programs." | 7.72 | Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes. ( Krantz, MJ; Kutinsky, IB; Mehler, PS; Robertson, AD, 2003) |
| "Methadone maintenance treatment programs in the United States and a pain management center in Canada." | 7.71 | Torsade de pointes associated with very-high-dose methadone. ( Hays, H; Krantz, MJ; Lewkowiez, L; Mehler, PS; Robertson, AD; Woodroffe, MA, 2002) |
| "Methadone is a synthetic opioid frequently used in drug maintenance programs for heroin addicts." | 6.43 | Methadone-induced Torsade de pointes tachycardias. ( Ammann, P; Maeder, M; Osswald, S; Schaer, BA; Sticherling, C, 2005) |
| "Methadone maintenance treatment (MMT) for opioid dependency has consistently shown important heath, social and legal benefits." | 6.43 | Methadone death, dosage and torsade de pointes: risk-benefit policy implications. ( Latowsky, M, 2006) |
| "Torsade de pointes is a rare but potentially fatal ventricular arrhythmia that is often triggered by drugs that prolong the rate-corrected QT (QTc) interval." | 5.33 | Effects of buprenorphine on cardiac repolarization in a patient with methadone-related torsade de pointes. ( Garcia, JA; Krantz, MJ; Mehler, PS, 2005) |
| "Methadone is highly effective in treating opioid dependence, and it is also used as an analgesic for second-line management of chronic pain." | 4.86 | Methadone deaths: risk factors in pain and addicted populations. ( Brooks, D; Modesto-Lowe, V; Petry, N, 2010) |
| "Methadone is increasingly prescribed for chronic pain, yet the associated mortality appears to be rising disproportionately relative to other opioid analgesics." | 4.85 | Methadone-induced mortality in the treatment of chronic pain: role of QT prolongation. ( Andrews, CM; Capacchione, JF; Haigney, MC; Krantz, MJ; Marcuson, MJ; Wedam, EF, 2009) |
| "To examine the recent literature with regards to methadone, prolongation of the QT interval, torsade de pointes and the implications for palliative care clinicians." | 4.85 | Prolonged QT interval and methadone: implications for palliative care. ( Beattie, JM; Wilcock, A, 2009) |
| "The full potential of methadone maintenance treatment (MMT) is often limited by the large inter-individual variability in both pharmacokinetics (PK) and pharmacodynamics (PD), and by the risk of torsade de pointes, a severe adverse effect caused by QTc prolongation." | 4.12 | A genetic-based population PK/PD modeling of methadone in Chinese opiate dependence patients. ( Guo, D; Lou, X; Shi, S; Shu, Y; Tan, Z; Yang, H; Yu, L; Zhou, H, 2022) |
| "We report here 2 cases of methadone induced Torsades de Pointes with a clinical presentation mimicking convulsive seizures in a substance abuser." | 3.83 | When a seizure is not a real seizure! ( Chaudhari, S; Ghobadi, F; Gracia, E; Hassen, GW; Olatunde, O; Pekler, G; Talebi, S; Visco, F, 2016) |
| "To assess the relative frequency of reporting of adverse events involving ventricular arrhythmia, cardiac arrest, corrected QT interval (QTc) prolongation or torsade de pointes to the US Food and Drug Administration (FDA) between buprenorphine and methadone." | 3.81 | Arrhythmia associated with buprenorphine and methadone reported to the Food and Drug Administration. ( Haigney, MC; Kao, DP; Krantz, MJ; Mehler, PS, 2015) |
| "Corrected QT interval (QTc) prolongation is long considered as a predisposing factor for the occurrence of torsade de pointes (TdP) and sudden cardiac arrest in methadone maintenance treatment." | 3.80 | The correlation between prolonged corrected QT interval with the frequency of respiratory arrest, endotracheal intubation, and mortality in acute methadone overdose. ( Azizi, Z; Farsi, D; Hassanian-Moghaddam, H; Jamshidnejad, N; Mirafzal, A; Zehtabchi, S, 2014) |
| "We report a case of nearly fatal ventricular tachyarrhythmia type Torsade de pointes caused by medication-induced prolongation of QTc duration (methadone, ondansetron, escitalopram)." | 3.79 | [Drug-induced malignant arrhythmias. IT prevents lethal drug mixtures]. ( Flury, G; Neumeier, C; Thaler, S, 2013) |
| "1646 cases of ventricular arrhythmia or cardiac arrest and 379 cases of QTc prolongation or torsade de pointes were associated with methadone." | 3.79 | Trends in reporting methadone-associated cardiac arrhythmia, 1997-2011: an analysis of registry data. ( Bucher Bartelson, B; Dart, R; Kao, D; Katz, D; Khatri, V; Krantz, MJ; Mehler, PS, 2013) |
| "Several studies have reported prolonged QTc intervals in patients under methadone maintenance treatment, including development of torsade-de-pointes arrhythmia and death." | 3.79 | QTc prolongation in methadone maintenance--the role of HCV infection. ( Boesch, L; Bruggmann, P; Falcato, L; Gholami, N; Stohler, R, 2013) |
| "High-dose methadone has been associated with rate-corrected QT (QTc) prolongation and 'torsade de pointes'." | 3.77 | Methadone maintenance, QTc and torsade de pointes: who needs an electrocardiogram and what is the prevalence of QTc prolongation? ( Gossop, M; Lintzeris, N; Markides, V; Mayet, S; Strang, J, 2011) |
| "Illicit drugs such as cocaine, and methadone can induce acquired long QT syndrome." | 3.77 | Cardiovascular-associated disease in an addicted population: an observation study. ( Bignamini, E; Cappa, C; Compostino, R; De Vivo, E; Demarie, D; Ferro, S; Imazio, M; Marletta, G; Trinchero, R, 2011) |
| "Methadone, a pharmacological agent used to treat heroin dependence is relatively safe, but may cause cardiac arrhythmias in the concurrent presence of other risk factors." | 3.75 | Itraconazole-induced torsade de pointes in a patient receiving methadone substitution therapy. ( Narayanan, S; NoorZurani, MH; Vicknasingam, B, 2009) |
| "Methadone is associated with prolongation of the corrected QT interval (QTc) and torsade de pointes in case series, cross sectional studies, a prospective cohort study, and one randomized trial." | 3.74 | Heterogeneous impact of methadone on the QTc interval: what are the practical implications? ( Krantz, MJ, 2008) |
| "A woman developed a prolonged QT interval and torsade de pointes while on methadone treatment for heroin addiction." | 3.73 | A twist on torsade: a prolonged QT interval on methadone. ( Hunt, SC; Lamont, P, 2006) |
| "Outpatient pain management center and methadone maintenance treatment programs." | 3.72 | Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes. ( Krantz, MJ; Kutinsky, IB; Mehler, PS; Robertson, AD, 2003) |
| "Methadone maintenance treatment programs in the United States and a pain management center in Canada." | 3.71 | Torsade de pointes associated with very-high-dose methadone. ( Hays, H; Krantz, MJ; Lewkowiez, L; Mehler, PS; Robertson, AD; Woodroffe, MA, 2002) |
| "To reduce the risk of cardiac arrhythmias and to improve patient outcomes, consideration of accurate patient selection, concomitant medications, electrolyte monitoring, and vigilant ECG monitoring should be considered." | 2.82 | Effects of opioid receptor agonist and antagonist medications on electrocardiogram changes and presentation of cardiac arrhythmia: review article. ( Catanzaro, JN; Delisle, BP; Di Biase, L; Elayi, CS; Etaee, F; Komaki, A; Natale, A; Tobin, M; Vuppala, S, 2022) |
| "Methadone is a synthetic opioid frequently used in drug maintenance programs for heroin addicts." | 2.43 | Methadone-induced Torsade de pointes tachycardias. ( Ammann, P; Maeder, M; Osswald, S; Schaer, BA; Sticherling, C, 2005) |
| "Methadone maintenance treatment (MMT) for opioid dependency has consistently shown important heath, social and legal benefits." | 2.43 | Methadone death, dosage and torsade de pointes: risk-benefit policy implications. ( Latowsky, M, 2006) |
| "Methadone is a widely used opioid agonist treatment associated with QT prolongation and torsades de pointes." | 1.46 | QT interval prolongation in opioid agonist treatment: analysis of continuous 12-lead electrocardiogram recordings. ( Brown, AL; Calver, L; Dunlop, AJ; Gill, A; Isbister, GK; Scott, AJ, 2017) |
| "Methadone was by far the leading medication implicated in the development of TdP and an independent predictor in both univariate and multivariate analyses despite the fact that it was not the most common QT-prolonging medication in our population." | 1.43 | Drug-induced torsades de pointes in an underserved urban population. Methadone: is there therapeutic equipoise? ( Baldinger, SH; Di Biase, L; Engstrom, K; Ferrick, KJ; Fisher, JD; Garcia, MJ; Golive, A; Goodman-Meza, D; Gross, J; Kim, S; Krumerman, A; Makkiya, M; Medrano, F; Rangasamy, S; Romero, J; Valencia, CR, 2016) |
| "Torsades de pointes is a polymorphic ventricular tachycardia that can quickly evolve into ventricular fibrillation and sudden death." | 1.39 | Methadone-induced Torsades de pointes. ( Levine, D; Russell, L, 2013) |
| "Sudden cardiac death was recorded in five patients, and torsade de pointes was recorded in seven other patients." | 1.39 | Drug-induced long QT in adult psychiatric inpatients: the 5-year cross-sectional ECG Screening Outcome in Psychiatry study. ( Berney, P; Dayer, P; Gaspoz, JM; Gex-Fabry, M; Girardin, FR; Shah, D, 2013) |
| "Methadone dose was reduced in five patients with improvement of QT interval and resolution of arrhythmia." | 1.36 | Ventricular arrhythmias in patients treated with methadone for opioid dependence. ( Hanon, S; Rosman, J; Schweitzer, P; Seewald, RM; Yang, F, 2010) |
| "Both methadone and heroin inhibit hERG currents in a concentration-dependent manner." | 1.36 | Comparison of the effects of methadone and heroin on human ether-à-go-go-related gene channels. ( Wos-Maganga, M; Zünkler, BJ, 2010) |
| "To investigate spontaneous reports of TdP present in the public version of the FDA Adverse Event Reporting System (AERS) in the light of what is already known on their TdP-liability." | 1.35 | Drug-induced torsades de pointes: data mining of the public version of the FDA Adverse Event Reporting System (AERS). ( De Ponti, F; Moretti, U; Poluzzi, E; Raschi, E, 2009) |
| " Additional electrocardiography is recommended if the methadone dosage exceeds 100 mg/d or if patients have unexplained syncope or seizures." | 1.35 | QTc interval screening in methadone treatment. ( Haigney, MC; Krantz, MJ; Martin, J; Mehta, D; Stimmel, B, 2009) |
| "Buprenorphine should be used for opiate dependence and chronic pain in patients with methadone-induced QT prolongation and as first line therapy in patients with risk factors for torsades de pointes." | 1.35 | Successful transition to buprenorphine in a patient with methadone-induced torsades de pointes. ( Do, LT; Esses, JL; Hanon, S; Rosman, J; Schweitzer, P, 2008) |
| " Both chronic use of large doses and a recent increase in the daily dose of methadone have been associated with QT prolongation and subsequent development of torsades de pointes." | 1.35 | Chronic methadone therapy complicated by torsades de pointes: a case report. ( Mayo, D; Pimentel, L, 2008) |
| "Methadone was subsequently shown to prolong the QT interval as well." | 1.34 | Physician awareness of the cardiac effects of methadone: results of a national survey. ( Bucher Bartelson, B; Krantz, MJ; Rowan, SB; Schmittner, J, 2007) |
| "Oral methadone therapy is an effective and increasingly popular treatment for opioid dependency and chronic pain." | 1.34 | QTc prolongation and torsades de pointes associated with methadone therapy. ( Brooks, DE; Katz, KD; Routhier, DD, 2007) |
| "(3) Methadone has a long plasma elimination half-life, and this poses a risk of accumulation." | 1.33 | Torsades de pointes with methadone. ( , 2005) |
| "Methadone is a synthetic opioid that has been used successfully to treat heroin addiction and chronic pain." | 1.33 | [Torsades de pointes during methadone treatment]. ( Almendral Garrote, J; Arenal Maíz, A; Atienza Fernández, F; González Torrecilla, E; Puchol Calderón, A; Sánchez Hernández, AM, 2005) |
| "Torsade de pointes is a rare but potentially fatal ventricular arrhythmia that is often triggered by drugs that prolong the rate-corrected QT (QTc) interval." | 1.33 | Effects of buprenorphine on cardiac repolarization in a patient with methadone-related torsade de pointes. ( Garcia, JA; Krantz, MJ; Mehler, PS, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 61 (60.40) | 29.6817 |
| 2010's | 36 (35.64) | 24.3611 |
| 2020's | 4 (3.96) | 2.80 |
| Authors | Studies |
|---|---|
| Kramer, J | 1 |
| Obejero-Paz, CA | 1 |
| Myatt, G | 1 |
| Kuryshev, YA | 1 |
| Bruening-Wright, A | 1 |
| Verducci, JS | 1 |
| Brown, AM | 1 |
| Etaee, F | 1 |
| Tobin, M | 1 |
| Vuppala, S | 1 |
| Komaki, A | 1 |
| Delisle, BP | 1 |
| Di Biase, L | 2 |
| Catanzaro, JN | 1 |
| Natale, A | 1 |
| Elayi, CS | 1 |
| Guo, D | 1 |
| Tan, Z | 1 |
| Lou, X | 1 |
| Shi, S | 1 |
| Shu, Y | 1 |
| Zhou, H | 1 |
| Yu, L | 1 |
| Yang, H | 1 |
| Ryan, K | 1 |
| Benz, P | 1 |
| Zosel, A | 1 |
| Farkas, A | 1 |
| Theobald, J | 1 |
| Mehta, A | 1 |
| Patel, BM | 1 |
| Isbister, GK | 1 |
| Brown, AL | 1 |
| Gill, A | 1 |
| Scott, AJ | 1 |
| Calver, L | 1 |
| Dunlop, AJ | 1 |
| Schwinghammer, AJ | 1 |
| Wilson, MD | 1 |
| Hall, BA | 1 |
| Krieg, B | 1 |
| Thaler, S | 1 |
| Neumeier, C | 1 |
| Flury, G | 1 |
| Kao, D | 2 |
| Bucher Bartelson, B | 2 |
| Khatri, V | 1 |
| Dart, R | 1 |
| Mehler, PS | 8 |
| Katz, D | 1 |
| Krantz, MJ | 13 |
| Pani, PP | 1 |
| Trogu, E | 1 |
| Maremmani, I | 1 |
| Pacini, M | 1 |
| Russell, L | 1 |
| Levine, D | 1 |
| Hasnain, M | 1 |
| Vieweg, WV | 1 |
| Breden Crouse, EL | 1 |
| Hancox, JC | 1 |
| Gholami, N | 1 |
| Boesch, L | 1 |
| Falcato, L | 1 |
| Stohler, R | 1 |
| Bruggmann, P | 1 |
| Katz, DF | 2 |
| Varosy, PD | 1 |
| Masoudi, FA | 1 |
| Laqueille, X | 1 |
| Genin, C | 1 |
| Pitrat, B | 1 |
| Lupuyau, A | 1 |
| Dervaux, A | 1 |
| Girardin, FR | 1 |
| Gex-Fabry, M | 1 |
| Berney, P | 1 |
| Shah, D | 1 |
| Gaspoz, JM | 1 |
| Dayer, P | 1 |
| Albright, K | 1 |
| Farsi, D | 1 |
| Mirafzal, A | 1 |
| Hassanian-Moghaddam, H | 1 |
| Azizi, Z | 1 |
| Jamshidnejad, N | 1 |
| Zehtabchi, S | 1 |
| Raina, S | 1 |
| Paydak, H | 1 |
| Al-Lahham, T | 1 |
| Shihabuddin, BS | 1 |
| Kao, DP | 1 |
| Haigney, MC | 6 |
| Walton, G | 1 |
| Nolan, S | 1 |
| Sutherland, C | 1 |
| Ahamad, K | 1 |
| Talebi, S | 1 |
| Ghobadi, F | 1 |
| Chaudhari, S | 1 |
| Gracia, E | 1 |
| Olatunde, O | 1 |
| Pekler, G | 1 |
| Visco, F | 1 |
| Hassen, GW | 1 |
| Romero, J | 1 |
| Baldinger, SH | 1 |
| Goodman-Meza, D | 1 |
| Engstrom, K | 1 |
| Valencia, CR | 1 |
| Golive, A | 1 |
| Medrano, F | 1 |
| Rangasamy, S | 1 |
| Makkiya, M | 1 |
| Fisher, JD | 1 |
| Gross, J | 1 |
| Krumerman, A | 1 |
| Kim, S | 1 |
| Garcia, MJ | 1 |
| Ferrick, KJ | 1 |
| Krantz, M | 1 |
| Esses, JL | 1 |
| Rosman, J | 2 |
| Do, LT | 1 |
| Schweitzer, P | 3 |
| Hanon, S | 2 |
| Martin, J | 1 |
| Stimmel, B | 4 |
| Mehta, D | 2 |
| Gourevitch, MN | 1 |
| Poluzzi, E | 1 |
| Raschi, E | 1 |
| Moretti, U | 1 |
| De Ponti, F | 1 |
| Stringer, J | 1 |
| Welsh, C | 1 |
| Tommasello, A | 1 |
| Andrews, CM | 1 |
| Wedam, EF | 1 |
| Marcuson, MJ | 1 |
| Capacchione, JF | 1 |
| Nair, MK | 1 |
| Patel, K | 1 |
| Starer, PJ | 1 |
| George, S | 2 |
| Moreira, K | 1 |
| Fapohunda, M | 1 |
| Cohen, SP | 1 |
| Mao, J | 1 |
| Byrne, A | 2 |
| Girgis, G | 1 |
| Bart, G | 2 |
| Wilcock, A | 1 |
| Beattie, JM | 1 |
| NoorZurani, MH | 1 |
| Vicknasingam, B | 1 |
| Narayanan, S | 1 |
| Modesto-Lowe, V | 1 |
| Brooks, D | 1 |
| Petry, N | 1 |
| Seewald, RM | 1 |
| Yang, F | 1 |
| Zünkler, BJ | 1 |
| Wos-Maganga, M | 1 |
| Hallinan, R | 1 |
| Newman, RG | 1 |
| Grant, KJ | 1 |
| Baca, CT | 1 |
| Nordt, SP | 1 |
| Zilberstein, J | 1 |
| Gold, B | 1 |
| Perrin-Terrin, A | 1 |
| Pathak, A | 1 |
| Lapeyre-Mestre, M | 1 |
| Demarie, D | 1 |
| Marletta, G | 1 |
| Imazio, M | 1 |
| Cappa, C | 1 |
| Ferro, S | 1 |
| Compostino, R | 1 |
| De Vivo, E | 1 |
| Trinchero, R | 1 |
| Bignamini, E | 1 |
| Mayet, S | 1 |
| Gossop, M | 1 |
| Lintzeris, N | 1 |
| Markides, V | 1 |
| Strang, J | 1 |
| Auguet-Mancini, P | 1 |
| Guyomar, Y | 1 |
| Cordova, H | 1 |
| Urso-Baiardo, L | 1 |
| Martin, JA | 1 |
| Campbell, A | 1 |
| Killip, T | 1 |
| Kotz, M | 1 |
| Kreek, MJ | 1 |
| McCarroll, BA | 1 |
| Payte, JT | 1 |
| Taylor, T | 1 |
| Wilford, BB | 1 |
| Stallvik, M | 1 |
| Nordstrand, B | 1 |
| Kristensen, Ø | 1 |
| Bathen, J | 1 |
| Skogvoll, E | 1 |
| Spigset, O | 1 |
| Lewkowiez, L | 1 |
| Hays, H | 1 |
| Woodroffe, MA | 1 |
| Robertson, AD | 2 |
| Walker, PW | 1 |
| Klein, D | 1 |
| Kasza, L | 1 |
| Kutinsky, IB | 1 |
| De Bels, D | 1 |
| Staroukine, M | 1 |
| Devriendt, J | 1 |
| Mokwe, EO | 1 |
| Ositadinma, O | 1 |
| Sala, M | 2 |
| Anguera, I | 2 |
| Cervantes, M | 2 |
| Gil, M | 1 |
| Chapinal, O | 1 |
| Guma, JR | 1 |
| Segura, F | 1 |
| Vodoz, JF | 1 |
| Jaquier, F | 1 |
| Lamy, O | 1 |
| Lucchini, A | 1 |
| Barbaro, G | 1 |
| Barbarini, G | 1 |
| Al-Shakarshi, JS | 1 |
| Bent-Hansen, L | 1 |
| Jensen, GB | 1 |
| Reddy, S | 1 |
| Fisch, M | 1 |
| Bruera, E | 1 |
| Krook, AL | 1 |
| Waal, H | 1 |
| Hansteen, V | 1 |
| Hrovatin, E | 1 |
| Zardo, F | 1 |
| Brieda, M | 1 |
| Dametto, E | 1 |
| Piazza, R | 1 |
| Antonini-Canterin, F | 1 |
| Cassin, M | 1 |
| Meneguzzo, N | 1 |
| Viel, E | 1 |
| Lestuzzi, C | 1 |
| Di Gennaro, G | 1 |
| Nicolosi, GL | 1 |
| Harris, JD | 1 |
| de Leon-Casasola, OA | 1 |
| Rowan, SB | 2 |
| Porter, BO | 1 |
| Coyne, PJ | 1 |
| Smith, WR | 1 |
| Cruciani, RA | 1 |
| Sekine, R | 1 |
| Homel, P | 1 |
| Lussier, D | 1 |
| Yap, Y | 1 |
| Suzuki, Y | 1 |
| Yancovitz, SR | 1 |
| Lapin, JA | 1 |
| Shaiova, L | 1 |
| Sheu, RG | 1 |
| Portenoy, RK | 1 |
| Pearson, EC | 1 |
| Woosley, RL | 2 |
| Garcia, JA | 1 |
| Sticherling, C | 1 |
| Schaer, BA | 1 |
| Ammann, P | 1 |
| Maeder, M | 1 |
| Osswald, S | 1 |
| Østvold, C | 1 |
| Topper, M | 1 |
| Sánchez Hernández, AM | 1 |
| Atienza Fernández, F | 1 |
| Arenal Maíz, A | 1 |
| González Torrecilla, E | 1 |
| Puchol Calderón, A | 1 |
| Almendral Garrote, J | 1 |
| Katchman, AN | 1 |
| Koerner, J | 1 |
| Tosaka, T | 1 |
| Ebert, SN | 1 |
| Fayez, K | 1 |
| Juan-Diego, H | 1 |
| Oscar A, de LC | 1 |
| Chatterjee, B | 1 |
| Bürgi, U | 1 |
| Justo, D | 2 |
| Gal-Oz, A | 1 |
| Paran, Y | 1 |
| Goldin, Y | 1 |
| Zeltser, D | 1 |
| Lamont, P | 1 |
| Hunt, SC | 1 |
| Moral Moral, P | 1 |
| Rueda Soriano, J | 1 |
| Tasias Pitarch, M | 1 |
| Calbuig Alborch, JR | 1 |
| Latowsky, M | 1 |
| Iskandar, SB | 1 |
| Abi-Saleh, BS | 1 |
| Mechleb, BK | 1 |
| Fahrig, SA | 1 |
| Routhier, DD | 1 |
| Katz, KD | 1 |
| Brooks, DE | 1 |
| Lüthi, B | 1 |
| Huttner, A | 1 |
| Speck, RF | 1 |
| Mueller, NJ | 1 |
| Al-Sardar, H | 1 |
| Ehret, GB | 1 |
| Desmeules, JA | 1 |
| Broers, B | 1 |
| Atkinson, D | 1 |
| Dunne, A | 1 |
| Parker, M | 1 |
| Pimentel, L | 1 |
| Mayo, D | 1 |
| Schmittner, J | 1 |
| Wong, SC | 1 |
| Roberts, JR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-label, Randomised Pilot Study Comparing the Efficacy, Safety and Tolerability of Raltegravir With Protease Inhibitor-based Therapy in Treatment-naïve, HIV/Hepatitis C Co-infected Injecting Drug Users Receiving Methadone[NCT01105611] | Phase 4 | 40 participants (Anticipated) | Interventional | 2010-08-31 | Recruiting | ||
| Development and Evaluation of a Methadone Protocol for Severe Chronic Pain Management[NCT02335398] | Phase 4 | 34 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for methadone and Torsade de Pointes
| Article | Year |
|---|---|
Effects of opioid receptor agonist and antagonist medications on electrocardiogram changes and presentation of cardiac arrhythmia: review article.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Electrocardiography; Humans; Long QT Syndrome; Methadone; | 2022 |
Long-acting opioids and cardiovascular diseases: Help or hindrance!
Topics: Analgesics, Opioid; Cardiovascular Diseases; Humans; Methadone; Receptors, Opioid; Torsades de Point | 2023 |
QTc interval screening for cardiac risk in methadone treatment of opioid dependence.
Topics: Humans; Methadone; Narcotics; Opioid-Related Disorders; Torsades de Pointes | 2013 |
Methadone-associated Q-T interval prolongation and torsades de pointes.
Topics: Animals; Humans; Long QT Syndrome; Methadone; Risk Factors; Torsades de Pointes | 2009 |
Methadone-induced mortality in the treatment of chronic pain: role of QT prolongation.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Chronic Disease; Delayed Rectifier Potassium Channels; ERG | 2009 |
Methadone and the heart: what the clinician needs to know.
Topics: Animals; Dose-Response Relationship, Drug; Female; Heart Conduction System; Humans; Infusions, Intra | 2008 |
Prolonged QT interval and methadone: implications for palliative care.
Topics: Female; Humans; Long QT Syndrome; Male; Methadone; Narcotics; Palliative Care; Patient Selection; To | 2009 |
Methadone deaths: risk factors in pain and addicted populations.
Topics: Analgesics, Opioid; Chronic Disease; Death, Sudden, Cardiac; Drug Overdose; Humans; Methadone; Opiat | 2010 |
Methadone-induced Torsade de pointes tachycardias.
Topics: Adult; Analgesics, Opioid; Cocaine-Related Disorders; Electrocardiography; Female; Humans; Long QT S | 2005 |
Methadone death, dosage and torsade de pointes: risk-benefit policy implications.
Topics: Electrocardiography; Humans; Methadone; Opioid-Related Disorders; Risk; Torsades de Pointes | 2006 |
Methadone and torsade de pointes: case report and review of the literature.
Topics: Adult; Defibrillators, Implantable; Electrocardiography; Female; Humans; Methadone; Narcotics; Torsa | 2007 |
Methadone-associated long QT syndrome: improving pharmacotherapy for dependence on illegal opioids and lessons learned for pharmacology.
Topics: Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Electr | 2007 |
2 trials available for methadone and Torsade de Pointes
| Article | Year |
|---|---|
QT interval prolongation: prevalence, risk factors and pharmacovigilance data among methadone-treated patients in France.
Topics: Adult; Death, Sudden; Death, Sudden, Cardiac; Female; France; Heart Diseases; Humans; Long QT Syndro | 2011 |
Measurement of QTc in patients receiving chronic methadone therapy.
Topics: Electrocardiography; Female; Heart Rate; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Pa | 2005 |
87 other studies available for methadone and Torsade de Pointes
| Article | Year |
|---|---|
MICE models: superior to the HERG model in predicting Torsade de Pointes.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp T | 2013 |
A genetic-based population PK/PD modeling of methadone in Chinese opiate dependence patients.
Topics: China; Dose-Response Relationship, Drug; Electrocardiography; Humans; Long QT Syndrome; Methadone; O | 2022 |
QTc Prolongation in Poison Center Exposures to CredibleMeds List of Substances with "Known Risk of Torsades de Pointes".
Topics: Amitriptyline; Arrhythmias, Cardiac; Diphenhydramine; Electrocardiography; Flecainide; Humans; Long | 2022 |
QT interval prolongation in opioid agonist treatment: analysis of continuous 12-lead electrocardiogram recordings.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Dose-Response Relationship, Drug; Electrocardiography; Fem | 2017 |
Corrected QT Interval Prolongation in Hospitalized Pediatric Patients Receiving Methadone.
Topics: Child; Child, Preschool; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Infa | 2018 |
Topics: Buprenorphine; Drug Interactions; Germany; Humans; Loperamide; Methadone; Opiate Substitution Treatm | 2016 |
[Drug-induced malignant arrhythmias. IT prevents lethal drug mixtures].
Topics: Adult; Analgesics, Opioid; Antidepressive Agents; Antidepressive Agents, Second-Generation; Citalopr | 2013 |
Trends in reporting methadone-associated cardiac arrhythmia, 1997-2011: an analysis of registry data.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Anti-Retroviral Agents; Heart Arrest; HIV Infections | 2013 |
Methadone-induced Torsades de pointes.
Topics: Female; Humans; Methadone; Middle Aged; Torsades de Pointes | 2013 |
Methadone and torsade de pointes: how can we better understand the association?
Topics: Age Factors; Analgesics, Opioid; Female; Humans; Long QT Syndrome; Male; Methadone; Risk Factors; Se | 2013 |
QTc prolongation in methadone maintenance--the role of HCV infection.
Topics: Adult; Analgesics, Opioid; Arrhythmias, Cardiac; Cross-Sectional Studies; Dose-Response Relationship | 2013 |
Syncope: a tale of two triggers.
Topics: Bradycardia; Dose-Response Relationship, Drug; Electrocardiography; Humans; Male; Methadone; Middle | 2013 |
Torsade de Pointes associated with laxative abuse in a patient receiving methadone.
Topics: Bisacodyl; Feeding and Eating Disorders; Female; Humans; Laxatives; Methadone; Middle Aged; Torsades | 2013 |
Drug-induced long QT in adult psychiatric inpatients: the 5-year cross-sectional ECG Screening Outcome in Psychiatry study.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Case-Control Studies; Citalopram; Cross-Sectional Stu | 2013 |
An ECG-based cardiac safety initiative is well received by opioid treatment program staff: results from a qualitative assessment.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Attitude of Health Personnel; Electrocardiography; Humans; | 2013 |
The correlation between prolonged corrected QT interval with the frequency of respiratory arrest, endotracheal intubation, and mortality in acute methadone overdose.
Topics: Adolescent; Adult; Aged; Cross-Sectional Studies; Drug Overdose; Electrocardiography; Female; Humans | 2014 |
Methadone induced Torsades de Pointes mimicking seizures in clinical presentation.
Topics: Adult; Female; Humans; Methadone; Opioid-Related Disorders; Seizures; Torsades de Pointes | 2014 |
Arrhythmia associated with buprenorphine and methadone reported to the Food and Drug Administration.
Topics: Adult; Arrhythmias, Cardiac; Buprenorphine; Female; Heart Arrest; Humans; Long QT Syndrome; Male; Me | 2015 |
Sustained release oral morphine as an alternative to methadone for the treatment of opioid-use disorder post Torsades de Pointes cardiac arrest.
Topics: Administration, Oral; Delayed-Action Preparations; Electrocardiography; Heart Arrest; Humans; Male; | 2015 |
When a seizure is not a real seizure!
Topics: Diagnosis, Differential; Electrocardiography; Female; Humans; Male; Methadone; Middle Aged; Opiate S | 2016 |
Drug-induced torsades de pointes in an underserved urban population. Methadone: is there therapeutic equipoise?
Topics: Age Distribution; Causality; Comorbidity; Drug-Related Side Effects and Adverse Reactions; Female; H | 2016 |
Reply to Cataldo (2016): Arrhythmia associated with buprenorphine and methadone reported to the Food and Drug Administration.
Topics: Arrhythmias, Cardiac; Buprenorphine; Electrocardiography; Humans; Long QT Syndrome; Methadone; Torsa | 2016 |
Successful transition to buprenorphine in a patient with methadone-induced torsades de pointes.
Topics: Buprenorphine; Humans; Male; Methadone; Middle Aged; Narcotic Antagonists; Opioid-Related Disorders; | 2008 |
Heterogeneous impact of methadone on the QTc interval: what are the practical implications?
Topics: Adolescent; Adult; Analgesics, Opioid; Electrocardiography; Heroin Dependence; Humans; Long QT Syndr | 2008 |
QTc interval screening in methadone treatment.
Topics: Dose-Response Relationship, Drug; Drug Interactions; Electrocardiography; Female; Heroin Dependence; | 2009 |
Summaries for patients. QTc interval screening in methadone treatment.
Topics: Dose-Response Relationship, Drug; Drug Interactions; Electrocardiography; Female; Heroin Dependence; | 2009 |
First do no harm ... Reduction?
Topics: Analgesics, Opioid; Electrocardiography; Heroin Dependence; Humans; Methadone; Risk Factors; Torsade | 2009 |
Drug-induced torsades de pointes: data mining of the public version of the FDA Adverse Event Reporting System (AERS).
Topics: Adverse Drug Reaction Reporting Systems; Amiodarone; Anti-Bacterial Agents; Antidepressive Agents; A | 2009 |
Ciprofloxacin-induced torsades de pointes in a methadone-dependent patient.
Topics: Anti-Infective Agents; Ciprofloxacin; Drug Interactions; Humans; Male; Methadone; Middle Aged; Narco | 2008 |
Concerns about consensus guidelines for QTc interval screening in methadone treatment.
Topics: Electrocardiography; Heroin Dependence; Humans; Methadone; Narcotics; Practice Guidelines as Topic; | 2009 |
Concerns about consensus guidelines for QTc interval screening in methadone treatment.
Topics: Electrocardiography; Heroin Dependence; Humans; Methadone; Narcotics; Practice Guidelines as Topic; | 2009 |
Concerns about consensus guidelines for QTc interval screening in methadone treatment.
Topics: Electrocardiography; Heroin Dependence; Humans; Methadone; Narcotics; Practice Guidelines as Topic; | 2009 |
Concerns about consensus guidelines for QTc interval screening in methadone treatment.
Topics: Electrocardiography; Heroin Dependence; Humans; Methadone; Narcotics; Practice Guidelines as Topic; | 2009 |
Itraconazole-induced torsade de pointes in a patient receiving methadone substitution therapy.
Topics: Adult; Female; Heroin Dependence; Humans; Itraconazole; Methadone; Torsades de Pointes | 2009 |
Ventricular arrhythmias in patients treated with methadone for opioid dependence.
Topics: Adult; Cardiac Pacing, Artificial; Dose-Response Relationship, Drug; Drug Administration Schedule; E | 2010 |
Comparison of the effects of methadone and heroin on human ether-à-go-go-related gene channels.
Topics: Dose-Response Relationship, Drug; Electrophysiology; Ether-A-Go-Go Potassium Channels; HEK293 Cells; | 2010 |
Does electrocardiography improve methadone safety?
Topics: Cause of Death; Electrocardiography; Humans; Long QT Syndrome; Methadone; Narcotics; Norway; Opioid- | 2010 |
Methadone deaths in pain and addiction populations.
Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Pain; Palliative Care; Substance-Related Dis | 2010 |
Methadone-induced torsade de pointes.
Topics: Analgesics, Opioid; Humans; Male; Methadone; Middle Aged; Neuralgia; Torsades de Pointes | 2011 |
Cardiovascular-associated disease in an addicted population: an observation study.
Topics: Adult; Buprenorphine; Cardiovascular Diseases; Electrocardiography; Female; Humans; Hypertension; Lo | 2011 |
Methadone maintenance, QTc and torsade de pointes: who needs an electrocardiogram and what is the prevalence of QTc prolongation?
Topics: Adult; Analgesics, Opioid; Cross-Sectional Studies; Electrocardiography; Female; Humans; London; Lon | 2011 |
[Torsades de pointes with methadone treatment].
Topics: Adult; Humans; Male; Methadone; Opiate Substitution Treatment; Torsades de Pointes | 2012 |
QT or not QT, that is the question: routine electrocardiograms for individuals in methadone maintenance treatment.
Topics: Humans; Long QT Syndrome; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Patien | 2011 |
First, do no harm: QT interval screening in methadone maintenance treatment.
Topics: Humans; Long QT Syndrome; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Patien | 2011 |
QT interval screening in methadone maintenance treatment: report of a SAMHSA expert panel.
Topics: Humans; Long QT Syndrome; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Patien | 2011 |
CSAT's QT interval screening in methadone report: outrageous fortune or sea of troubles?
Topics: Humans; Long QT Syndrome; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Patien | 2011 |
Corrected QT interval during treatment with methadone and buprenorphine--relation to doses and serum concentrations.
Topics: Adult; Arrhythmias, Cardiac; Buprenorphine; Electrocardiography; Female; Humans; International Class | 2013 |
Torsade de pointes associated with very-high-dose methadone.
Topics: Adult; Analgesics, Opioid; Canada; Chronic Disease; Electrocardiography; Female; Heroin Dependence; | 2002 |
Summaries for patients. Very high doses of methadone may cause abnormal heart rhythm.
Topics: Adult; Analgesics, Opioid; Canada; Chronic Disease; Female; Heroin Dependence; Humans; Male; Methado | 2002 |
High dose methadone and ventricular arrhythmias: a report of three cases.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Arrhythmias, Cardiac; Drug Interactions; Heart Vent | 2003 |
Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes.
Topics: Adult; Aged; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Hypokalemia; Lon | 2003 |
Torsades de pointes due to methadone.
Topics: Heroin Dependence; Humans; Methadone; Torsades de Pointes | 2003 |
Torsade de pointes due to methadone.
Topics: Adult; Analgesics, Opioid; Female; Humans; Methadone; Torsades de Pointes | 2003 |
Torsade de pointes due to methadone.
Topics: Adult; Analgesics, Opioid; HIV Infections; Humans; Male; Methadone; Torsades de Pointes | 2003 |
QT prolongation and Torsades de Pointes in patients infected with human immunodeficiency virus and treated with methadone.
Topics: Adult; Analgesics, Opioid; Antiretroviral Therapy, Highly Active; Dose-Response Relationship, Drug; | 2003 |
[Torsade de pointes: a severe and unknown adverse effect in a patient taking methadone].
Topics: Adult; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diagnosis, Differential; Electrocardi | 2003 |
Methadone and affairs of the heart and of the brain.
Topics: Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Electrocardiography; Humans; Long QT Syndr | 2003 |
Possible association between methadone and potentially fatal cardiac arrhythmia.
Topics: Analgesics, Opioid; Humans; Methadone; Torsades de Pointes | 2003 |
Methadone and QT prolongation: a dose-dependent effect?
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Humans; Long QT Syndrome; Methadone; Torsades | 2004 |
Methadone and QT prolongation in HIV-infected patients.
Topics: Analgesics, Opioid; HIV Infections; Humans; Long QT Syndrome; Methadone; Torsades de Pointes | 2004 |
[Life-threatening, recurrent arrhythmia in patients on high-dose methadone treatment: torsade de pointes].
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Risk Facto | 2004 |
Oral methadone for cancer pain: no indication of Q-T interval prolongation or torsades de pointes.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Electrocardiography; Heart Rate; Humans; Methadone; Neopla | 2004 |
[Routine ECG in methadone-assisted rehabilitation is wrong prioritization].
Topics: Dose-Response Relationship, Drug; Electrocardiography; Humans; Long QT Syndrome; Methadone; Narcotic | 2004 |
[Long QT and torsade de pointes in a patient with acquired human immunodeficiency virus infection in multitherapy with drugs affecting cytochrome P450].
Topics: Acquired Immunodeficiency Syndrome; Analgesics, Opioid; Antifungal Agents; Antiretroviral Therapy, H | 2004 |
Oral erythromycin and the risk of sudden death.
Topics: Anti-Bacterial Agents; Cytochrome P-450 Enzyme Inhibitors; Death, Sudden, Cardiac; Drug Interactions | 2005 |
Cocaine-related torsade de pointes in a methadone maintenance patient.
Topics: Cocaine; Dopamine Uptake Inhibitors; Drug Interactions; Female; Heart Arrest; Heroin Dependence; Hum | 2005 |
Methadone-related Torsades de Pointes in a sickle cell patient treated for chronic pain.
Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Male; Methadone; Pain; Torsades de Pointes | 2005 |
Torsades de pointes with methadone.
Topics: Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Drug Interactions; Heroin; Humans; Hypokalemia; L | 2005 |
QT prolongation and torsades de pointes among methadone users: reports to the FDA spontaneous reporting system.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Databases, Factual; Female; Humans | 2005 |
Effects of buprenorphine on cardiac repolarization in a patient with methadone-related torsade de pointes.
Topics: Analgesics, Opioid; Buprenorphine; Dose-Response Relationship, Drug; Heroin Dependence; Humans; Male | 2005 |
[Methadone-induced heart arrhythmia].
Topics: Adult; Electrocardiography; Fatal Outcome; Female; Humans; Long QT Syndrome; Male; Methadone; Middle | 2005 |
[Torsades de pointes during methadone treatment].
Topics: Adult; Analgesics, Opioid; Female; Humans; Male; Methadone; Torsades de Pointes | 2005 |
Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs.
Topics: Animals; Arsenic Trioxide; Arsenicals; Cells, Cultured; Electrocardiography; ERG1 Potassium Channel; | 2006 |
Re: Methadone in the management of intractable neuropathic noncancer pain.
Topics: Analgesics, Opioid; Electrocardiography; Humans; Long QT Syndrome; Methadone; Neuralgia; Pain, Intra | 2006 |
Syncope of a drug addict - a special case.
Topics: Adult; Female; Heroin Dependence; Humans; Long QT Syndrome; Methadone; Narcotics; Syncope; Torsades | 2006 |
Methadone-associated Torsades de Pointes (polymorphic ventricular tachycardia) in opioid-dependent patients.
Topics: Adult; Female; Heroin Dependence; Humans; Hypokalemia; Methadone; Middle Aged; Narcotics; Renal Insu | 2006 |
A twist on torsade: a prolonged QT interval on methadone.
Topics: Female; Humans; Long QT Syndrome; Methadone; Middle Aged; Torsades de Pointes | 2006 |
[Torsade de Pointes in patient infected with human immunodeficiency virus and treated with methadone].
Topics: HIV Infections; Humans; Male; Methadone; Middle Aged; Narcotics; Torsades de Pointes | 2006 |
Methadone-induced long QT syndrome vs methadone-induced torsades de pointes.
Topics: Adolescent; Adult; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Methadone; Middle Ag | 2006 |
QTc prolongation and torsades de pointes associated with methadone therapy.
Topics: Electrocardiography; Female; Humans; Long QT Syndrome; Methadone; Middle Aged; Narcotics; Opioid-Rel | 2007 |
Methadone-induced Torsade de pointes after stopping lopinavir-ritonavir.
Topics: Analgesics, Opioid; Anti-Retroviral Agents; Drug Administration Schedule; Drug Combinations; Drug In | 2007 |
Methadone-associated QT prolongation and torsades de pointes.
Topics: Analgesics, Opioid; Humans; Long QT Syndrome; Methadone; Opioid-Related Disorders; Torsades de Point | 2007 |
Methadone-associated QT prolongation and torsades de pointes. Dubrey and Groscott-Mason's patient was underttreated for her atrial fibrillation.
Topics: Analgesics, Opioid; Atrial Fibrillation; Humans; Long QT Syndrome; Methadone; Opioid-Related Disorde | 2007 |
Torsades de pointes and self-terminating ventricular fibrillation in a prescription methadone user.
Topics: Electrocardiography; Humans; Male; Methadone; Middle Aged; Substance Abuse, Intravenous; Torsades de | 2007 |
Chronic methadone therapy complicated by torsades de pointes: a case report.
Topics: Adult; Defibrillators, Implantable; Electrocardiography; Female; Heroin Dependence; Humans; Methadon | 2008 |
Physician awareness of the cardiac effects of methadone: results of a national survey.
Topics: Arrhythmias, Cardiac; Awareness; Heroin Dependence; Humans; Long QT Syndrome; Methadone; Narcotics; | 2007 |
Case files of the Drexel University Medical Toxicology Fellowship: methadone-induced QTc prolongation.
Topics: Adult; Drug Overdose; Electrocardiography; Emergency Medical Services; Humans; Long QT Syndrome; Mal | 2007 |