Page last updated: 2024-10-30

methadone and Suicidal Ideation

methadone has been researched along with Suicidal Ideation in 8 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Suicidal Ideation: A risk factor for suicide attempts and completions, it is the most common of all suicidal behavior, but only a minority of ideators engage in overt self-harm.

Research Excerpts

ExcerptRelevanceReference
" The objective of this study was to examine the prevalence and correlates of suicide attempt in Chinese individuals receiving methadone maintenance treatment for heroin dependence."7.91Prevalence and correlates of suicide attempt among Chinese individuals receiving methadone maintenance treatment for heroin dependence. ( Chen, H; Lu, J; Xie, WX; Zhong, BL; Zhu, JH, 2019)
" Methadone maintenance treatment (MMT) is an evidence-based effective treatment for drug addiction; however, there are few studies investigating depression, suicidal ideation, and their related factors among MMT users."7.83Depression, suicidal ideation, and related factors of methadone maintenance treatment users in Guangzhou, China. ( Davis, A; Gu, J; Hao, C; Hao, Y; Lau, JT; Xu, H; Zhang, X; Zhao, Y, 2016)
"There is a dearth of information about mothers in methadone maintenance treatment (MMT), their parental stress, and suicidal ideation."7.83Suicidal Ideation Among Heroin-Abusing Mothers in Methadone Maintenance Treatment. ( Isralowitz, R; Reznik, A; Sarid, O; Yehudai, M, 2016)
" The objective of this study was to examine the prevalence and correlates of suicide attempt in Chinese individuals receiving methadone maintenance treatment for heroin dependence."3.91Prevalence and correlates of suicide attempt among Chinese individuals receiving methadone maintenance treatment for heroin dependence. ( Chen, H; Lu, J; Xie, WX; Zhong, BL; Zhu, JH, 2019)
" Methadone maintenance treatment (MMT) is an evidence-based effective treatment for drug addiction; however, there are few studies investigating depression, suicidal ideation, and their related factors among MMT users."3.83Depression, suicidal ideation, and related factors of methadone maintenance treatment users in Guangzhou, China. ( Davis, A; Gu, J; Hao, C; Hao, Y; Lau, JT; Xu, H; Zhang, X; Zhao, Y, 2016)
"There is a dearth of information about mothers in methadone maintenance treatment (MMT), their parental stress, and suicidal ideation."3.83Suicidal Ideation Among Heroin-Abusing Mothers in Methadone Maintenance Treatment. ( Isralowitz, R; Reznik, A; Sarid, O; Yehudai, M, 2016)
"Among individuals with opioid use disorder (OUD), medications for OUD (MOUD) may lower suicide risk."1.72Association between clinically recognized suicidality and subsequent initiation or continuation of medications for opioid use disorder. ( Blosnich, JR; Edelman, EJ; Frost, MC; Hawkins, EJ; Richards, JE; Tsui, JI; Williams, EC, 2022)
"For methadone, there were significant reductions in the rate of suicidal behaviors (hazard ratio=0."1.48Medications for Alcohol and Opioid Use Disorders and Risk of Suicidal Behavior, Accidental Overdoses, and Crime. ( Binswanger, IA; Fazel, S; Hellner, C; Larsson, H; Molero, Y; Zetterqvist, J, 2018)
"The burden of opiate dependence not only relies on somatic complications such as infectious diseases or acute intoxication but also on frequent psychiatric events such as major depressive disorder (MDD) and suicidal behavior (SB)."1.42A cannabinoid receptor 1 polymorphism is protective against major depressive disorder in methadone-maintained outpatients. ( Bellivier, F; Bloch, V; Hajj, A; Icick, R; Karsinti, E; Ksouda, K; Laplanche, JL; Lépine, JP; Mouly, S; Peoc'h, K; Prince, N; Vorspan, F, 2015)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (75.00)24.3611
2020's2 (25.00)2.80

Authors

AuthorsStudies
Frost, MC1
Richards, JE1
Blosnich, JR1
Hawkins, EJ1
Tsui, JI1
Edelman, EJ1
Williams, EC1
Zhong, BL1
Xie, WX1
Zhu, JH1
Lu, J1
Chen, H1
Chen, WT1
Wang, SC1
Wang, IA1
Tsay, JH1
Chen, CY1
El Hage, C1
Ghabrash, MF1
Dubreucq, S1
Brissette, S1
Lespérance, F1
Lespérance, P1
Ouellet-Plamondon, C1
Bruneau, J1
Jutras-Aswad, D1
Molero, Y1
Zetterqvist, J1
Binswanger, IA1
Hellner, C1
Larsson, H1
Fazel, S1
Icick, R1
Peoc'h, K1
Karsinti, E1
Ksouda, K1
Hajj, A1
Bloch, V1
Prince, N1
Mouly, S1
Bellivier, F1
Lépine, JP1
Laplanche, JL1
Vorspan, F1
Zhang, X1
Xu, H1
Gu, J1
Lau, JT1
Hao, C1
Zhao, Y1
Davis, A1
Hao, Y1
Sarid, O1
Isralowitz, R1
Yehudai, M1
Reznik, A1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Open-Label Pilot Study of Desvenlafaxine for Opioid-Dependent Patients With Comorbid Depression[NCT02200406]Phase 418 participants (Actual)Interventional2014-07-31Completed
Factors Associated With the Variance of Oral Methadone Dosage at Steady State of Maintenance Treatment: Description of Bio-markers of Phenotype and Genotype.[NCT00894452]210 participants (Actual)Observational2008-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for methadone and Suicidal Ideation

ArticleYear
A pilot, open-label, 8-week study evaluating desvenlafaxine for treatment of major depression in methadone-maintained individuals with opioid use disorder.
    International clinical psychopharmacology, 2018, Volume: 33, Issue:5

    Topics: Adult; Antidepressive Agents; Anxiety; Craving; Depressive Disorder, Major; Desvenlafaxine Succinate

2018

Other Studies

7 other studies available for methadone and Suicidal Ideation

ArticleYear
Association between clinically recognized suicidality and subsequent initiation or continuation of medications for opioid use disorder.
    Drug and alcohol dependence, 2022, 08-01, Volume: 237

    Topics: Analgesics, Opioid; Buprenorphine; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related

2022
Prevalence and correlates of suicide attempt among Chinese individuals receiving methadone maintenance treatment for heroin dependence.
    Scientific reports, 2019, 10-30, Volume: 9, Issue:1

    Topics: Adult; Antisocial Personality Disorder; Anxiety; China; Depressive Disorder, Major; Female; Heroin;

2019
Suicide attempts and death among heroin-involved women seeking methadone treatment in Taiwan.
    Drug and alcohol dependence, 2020, 12-01, Volume: 217

    Topics: Adult; Cohort Studies; Female; Heroin Dependence; Humans; Longitudinal Studies; Methadone; Middle Ag

2020
Medications for Alcohol and Opioid Use Disorders and Risk of Suicidal Behavior, Accidental Overdoses, and Crime.
    The American journal of psychiatry, 2018, 10-01, Volume: 175, Issue:10

    Topics: Acamprosate; Adult; Aged; Alcohol Deterrents; Alcoholism; Buprenorphine; Cohort Studies; Crime; Drug

2018
A cannabinoid receptor 1 polymorphism is protective against major depressive disorder in methadone-maintained outpatients.
    The American journal on addictions, 2015, Volume: 24, Issue:7

    Topics: Adult; Alleles; Depressive Disorder, Major; Female; Humans; Male; Methadone; Middle Aged; Opiate Sub

2015
Depression, suicidal ideation, and related factors of methadone maintenance treatment users in Guangzhou, China.
    AIDS care, 2016, Volume: 28, Issue:7

    Topics: Adult; China; Cross-Sectional Studies; Depression; Drug Users; Female; Humans; Interview, Psychologi

2016
Suicidal Ideation Among Heroin-Abusing Mothers in Methadone Maintenance Treatment.
    Crisis, 2016, Volume: 37, Issue:6

    Topics: Adult; Cross-Sectional Studies; Female; Heroin Dependence; Humans; Israel; Methadone; Middle Aged; M

2016