methadone has been researched along with Soft Tissue Infections in 3 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Soft Tissue Infections: Infections of non-skeletal tissue, i.e., exclusive of bone, ligaments, cartilage, and fibrous tissue. The concept is usually referred to as skin and soft tissue infections and usually subcutaneous and muscle tissue are involved. The predisposing factors in anaerobic infections are trauma, ischemia, and surgery. The organisms often derive from the fecal or oral flora, particularly in wounds associated with intestinal surgery, decubitus ulcer, and human bites. (From Cecil Textbook of Medicine, 19th ed, p1688)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe the case of an intravenous drug user affected by life-threatening Staphylococcus aureus-complicated skin and soft tissue infection with associated bacteraemia who, while on replacement therapy with methadone, required 11 mg/kg/day daptomycin to achieve trough (Cmin) and peak (Cmax) plasma levels similar to those observed with the standard dosage of 6 mg/kg in healthy volunteers (mean ± standard deviation: Cmin 12." | 1.40 | Daptomycin underexposure in a young intravenous drug user who was affected by life-threatening Staphylococcus aureus-complicated skin and soft tissue infection associated with bacteraemia. ( Bassetti, M; Cojutti, P; Crapis, M; Pea, F, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Figgatt, MC | 1 |
| Hincapie-Castillo, JM | 1 |
| Schranz, AJ | 1 |
| Dasgupta, N | 1 |
| Edwards, JK | 1 |
| Jackson, BE | 1 |
| Marshall, SW | 1 |
| Golightly, YM | 1 |
| Pea, F | 1 |
| Crapis, M | 1 |
| Cojutti, P | 1 |
| Bassetti, M | 1 |
| Dahlman, D | 1 |
| Håkansson, A | 1 |
| Björkman, P | 1 |
| Blomé, MA | 1 |
| Kral, AH | 1 |
3 other studies available for methadone and Soft Tissue Infections
| Article | Year |
|---|---|
Medications for Opioid Use Disorder and Mortality and Hospitalization Among People With Opioid Use-related Infections.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Hospitalization; Humans; Male; Methadone; Opiate S | 2024 |
Daptomycin underexposure in a young intravenous drug user who was affected by life-threatening Staphylococcus aureus-complicated skin and soft tissue infection associated with bacteraemia.
Topics: Analgesics, Opioid; Anti-Bacterial Agents; Bacteremia; Daptomycin; Drug Interactions; Drug Users; Hu | 2014 |
Correlates of Skin and Soft Tissue Infections in Injection Drug Users in a Syringe-Exchange Program in Malmö, Sweden.
Topics: Adult; Amphetamine-Related Disorders; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Drug | 2015 |