methadone has been researched along with Sleep Initiation and Maintenance Disorders in 14 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Sleep Initiation and Maintenance Disorders: Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Poor sleep is a major complaint of people with human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) and undergoing methadone maintenance therapy (MMT)." | 5.34 | Effects of treatment of sleep disorders on sleep, psychological and cognitive functioning and biomarkers in individuals with HIV/AIDS and under methadone maintenance therapy. ( Alikhani, M; Brand, S; Davarinejad, O; Dürsteler, K; Ebrahimi, A; Farnia, V; Khazaie, H; Mohamadi, E; Radmehr, F; Sadeghi Bahmani, D, 2020) |
| "The significance of the insomnia findings was mainly contributed by a subgroup of patients who had a positive urine morphine test (p<0." | 2.77 | Genetic polymorphisms in the opioid receptor mu1 gene are associated with changes in libido and insomnia in methadone maintenance patients. ( Chen, AC; Chen, CH; Chen, YT; Chiang, IC; Chou, SY; Fang, KC; Fang, YC; Ho, IK; Hsiao, CF; Huang, CL; Kuo, HW; Lin, KM; Lin, YF; Liu, ML; Liu, SC; Liu, YL; Su, LW; Tian, JN; Tsou, HH; Wang, SC; Wu, HY, 2012) |
| "This trial was aimed to estimate the pharmacokinetic interaction between voriconazole and methadone at steady state in male patients on methadone therapy and to characterize the safety and tolerability profile during the coadministration." | 2.73 | Pharmacokinetic interaction between voriconazole and methadone at steady state in patients on methadone therapy. ( Foster, G; Labadie, R; Liu, P; Sharma, A; Somoza, E, 2007) |
| "Methadone was investigated to see if it induced an insomnia comparable to that after single doses of morphine." | 2.65 | Morphinelike arousal by methadone during sleep. ( Kay, DC; Neidert, GL; Pickworth, WB, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (21.43) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 3 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Halim, AA | 1 |
| Alsayed, B | 1 |
| Embarak, S | 1 |
| Yaseen, T | 1 |
| Dabbous, S | 1 |
| Fontaine, O | 1 |
| Dueluzeau, R | 1 |
| Raibaud, P | 1 |
| Chabanet, C | 1 |
| Popoff, MR | 1 |
| Badoual, J | 1 |
| Gabilan, JC | 1 |
| Andremont, A | 1 |
| Gómez, L | 1 |
| Andrés, S | 1 |
| Sánchez, J | 1 |
| Alonso, JM | 1 |
| Rey, J | 1 |
| López, F | 1 |
| Jiménez, A | 1 |
| Yan, Z | 1 |
| Zhou, L | 1 |
| Zhao, Y | 3 |
| Wang, J | 6 |
| Huang, L | 2 |
| Hu, K | 1 |
| Liu, H | 4 |
| Wang, H | 3 |
| Guo, Z | 1 |
| Song, Y | 1 |
| Huang, H | 4 |
| Yang, R | 1 |
| Owen, TW | 1 |
| Al-Kaysi, RO | 1 |
| Bardeen, CJ | 1 |
| Cheng, Q | 1 |
| Wu, S | 1 |
| Cheng, T | 1 |
| Zhou, X | 1 |
| Wang, B | 4 |
| Zhang, Q | 4 |
| Wu, X | 2 |
| Yao, Y | 3 |
| Ochiai, T | 1 |
| Ishiguro, H | 2 |
| Nakano, R | 2 |
| Kubota, Y | 2 |
| Hara, M | 1 |
| Sunada, K | 1 |
| Hashimoto, K | 1 |
| Kajioka, J | 1 |
| Fujishima, A | 1 |
| Jiao, J | 3 |
| Gai, QY | 3 |
| Wang, W | 2 |
| Zang, YP | 2 |
| Niu, LL | 2 |
| Fu, YJ | 3 |
| Wang, X | 4 |
| Yao, LP | 1 |
| Qin, QP | 1 |
| Wang, ZY | 1 |
| Liu, J | 4 |
| Aleksic Sabo, V | 1 |
| Knezevic, P | 1 |
| Borges-Argáez, R | 1 |
| Chan-Balan, R | 1 |
| Cetina-Montejo, L | 1 |
| Ayora-Talavera, G | 1 |
| Sansores-Peraza, P | 1 |
| Gómez-Carballo, J | 1 |
| Cáceres-Farfán, M | 1 |
| Jang, J | 1 |
| Akin, D | 1 |
| Bashir, R | 1 |
| Yu, Z | 1 |
| Zhu, J | 2 |
| Jiang, H | 1 |
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| Xiao, Z | 1 |
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| Sun, Q | 1 |
| Han, D | 1 |
| Lei, H | 1 |
| Zhao, K | 2 |
| Zhu, L | 1 |
| Li, X | 4 |
| Fu, H | 2 |
| Wilson, BK | 1 |
| Step, DL | 1 |
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| Gifford, CA | 1 |
| Richards, CJ | 1 |
| Krehbiel, CR | 1 |
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| Erickson, GE | 1 |
| Guretzky, JA | 1 |
| Rasby, RJ | 1 |
| Watson, AK | 1 |
| Klopfenstein, TJ | 1 |
| Sun, Y | 4 |
| Liu, Z | 3 |
| Pham, TD | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Behavioral Intervention to Improve Insomnia Symptoms in Patients With Opioid Use Disorder[NCT05588726] | 0 participants (Actual) | Interventional | 2022-01-01 | Withdrawn (stopped due to Staff no longer available to continue enrollment and other research activities) | |||
| Insomnia and Drug Relapse Risk[NCT00253890] | Phase 3 | 137 participants (Actual) | Interventional | 2005-10-31 | Completed | ||
| [NCT01059747] | 500 participants (Anticipated) | Observational | 2008-12-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of minutes spent sleeping during sleep period, as measured by daily sleep diary. (NCT00253890)
Timeframe: Baseline to 1-month
| Intervention | minutes (Mean) |
|---|---|
| Trazodone | 339 |
| Placebo | 329 |
2 reviews available for methadone and Sleep Initiation and Maintenance Disorders
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Use of psychotropic drugs in treatment of methadone maintained narcotic addicts.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Benzodiazepine | 1978 |
8 trials available for methadone and Sleep Initiation and Maintenance Disorders
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Effects of treatment of sleep disorders on sleep, psychological and cognitive functioning and biomarkers in individuals with HIV/AIDS and under methadone maintenance therapy.
Topics: Acquired Immunodeficiency Syndrome; Adult; Biomarkers; Cognition; Humans; Male; Methadone; Sleep; Sl | 2020 |
The Efficacy of Combined Electroacupuncture and Auricular Pressure on Sleep Quality in Patients Receiving Methadone Maintenance Treatment.
Topics: Acupuncture, Ear; Adult; Combined Modality Therapy; Cross-Over Studies; Electroacupuncture; Female; | 2021 |
Genetic polymorphisms in the opioid receptor mu1 gene are associated with changes in libido and insomnia in methadone maintenance patients.
Topics: Adult; Analgesics, Opioid; Benzodiazepines; Cohort Studies; Cross-Sectional Studies; Female; Genetic | 2012 |
[Acupuncture therapy for the improvement of sleep quality of outpatients receiving methadone maintenance treatment: a randomized controlled trial].
Topics: Acupuncture Therapy; Adult; Double-Blind Method; Female; Humans; Male; Methadone; Outpatients; Sleep | 2012 |
Pharmacokinetic interaction between voriconazole and methadone at steady state in patients on methadone therapy.
Topics: Adult; Antifungal Agents; Area Under Curve; Back Pain; Dose-Response Relationship, Drug; Double-Blin | 2007 |
Insomnia among addicts during supervised withdrawal from opiates: a comparison of oral methadone and electrostimulation.
Topics: Adult; Arousal; Electric Stimulation Therapy; Female; Humans; Male; Methadone; Opioid-Related Disord | 1984 |
Morphinelike arousal by methadone during sleep.
Topics: Adult; Arousal; Double-Blind Method; Humans; Male; Methadone; Middle Aged; Morphine; Muscle Contract | 1981 |
5 other studies available for methadone and Sleep Initiation and Maintenance Disorders
| Article | Year |
|---|---|
Benzodiazepine Use in Opioid Maintenance Treatment Programme: Risks and Clinical Outcomes.
Topics: Adult; Analgesics, Opioid; Anxiety; Benzodiazepines; Buprenorphine; Cross-Sectional Studies; Diazepa | 2021 |
Poor sleep quality is significantly associated with low sexual satisfaction in Chinese methadone-maintained patients.
Topics: Adult; China; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opiate Substitution Treatment | 2017 |
Inflammatory chemokine eotaxin-1 is correlated with age in heroin dependent patients under methadone maintenance therapy.
Topics: Adult; Aging; Amyloid beta-Peptides; Brain; Case-Control Studies; Chemokine CCL11; Cotinine; Female; | 2018 |
Insomnia and excessive daytime sleepiness in women and men receiving methadone and buprenorphine maintenance treatment.
Topics: Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Cross-Sectional Studies; Depression; | 2019 |
Insomnia among methadone-maintained individuals: the feasibility of collecting home polysomnographic recordings.
Topics: Adult; Clinical Trials as Topic; Feasibility Studies; Female; Humans; Illicit Drugs; Male; Methadone | 2009 |