methadone has been researched along with Sleep Apnea, Central in 7 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Sleep Apnea, Central: A condition associated with multiple episodes of sleep apnea which are distinguished from obstructive sleep apnea (SLEEP APNEA, OBSTRUCTIVE) by the complete cessation of efforts to breathe. This disorder is associated with dysfunction of central nervous system centers that regulate respiration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe a child with acute myeloid leukemia (AML) who developed severe central sleep apnea (CSA) on methadone therapy for chronic pain management." | 3.79 | Severe central sleep apnea in a child with leukemia on chronic methadone therapy. ( Amos, LB; D'Andrea, LA, 2013) |
| "Our objectives were to: (1) characterize obstructive sleep apnea (OSA) and CSA in patients in methadone maintenance treatment (MMT) for opioid dependence; (2) examine factors associated with SDB in this population; and (3) investigate whether SDB was related to severity of subjective sleep complaints in MMT patients with subjective sleep disturbances." | 1.36 | Obstructive sleep apnea is more common than central sleep apnea in methadone maintenance patients with subjective sleep complaints. ( Anderson, BJ; Corso, RP; Kurth, ME; Millman, RP; Sharkey, KM; Stein, MD, 2010) |
| "Thirty percent of MMT patients had a central apnea index (CAI) > 5, and 20% had a CAI > 10." | 1.33 | Central sleep apnea in stable methadone maintenance treatment patients. ( Cherry, G; Cunnington, D; Drummer, O; Goodman, C; Kronborg, I; Teichtahl, H; Wang, D, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, D | 3 |
| Lintzeris, N | 1 |
| Leung, S | 1 |
| Haber, PS | 1 |
| Yee, BJ | 1 |
| Grunstein, RR | 2 |
| Teichtahl, H | 3 |
| Goodman, C | 2 |
| Drummer, O | 2 |
| Kronborg, I | 3 |
| Sharkey, KM | 1 |
| Kurth, ME | 1 |
| Anderson, BJ | 1 |
| Corso, RP | 1 |
| Millman, RP | 1 |
| Stein, MD | 1 |
| Amos, LB | 1 |
| D'Andrea, LA | 1 |
| Durst, P | 1 |
| Palazzolo, J | 1 |
| Peyrelong, JP | 1 |
| Berger, M | 1 |
| Chalabreysse, M | 1 |
| Billiard, M | 1 |
| Vialle, A | 1 |
| Cherry, G | 2 |
| Cunnington, D | 1 |
| Prodromidis, A | 1 |
| Miller, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Acute Intravenous Morphine Administration on Sleep Disordered Breathing (SDB) in Patients With Moderate Obstructive Sleep Apnoea (OSA): A Paired Design Trial[NCT03127800] | Phase 3 | 6 participants (Actual) | Interventional | 2016-05-20 | Terminated (stopped due to Difficulties with recruitment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for methadone and Sleep Apnea, Central
| Article | Year |
|---|---|
Reversal of central sleep apnoea with change from methadone to buprenorphine-naloxone: a case report.
Topics: Buprenorphine, Naloxone Drug Combination; Heroin Dependence; Humans; Hypoxia; Male; Methadone; Middl | 2015 |
Subjective daytime sleepiness and daytime function in patients on stable methadone maintenance treatment: possible mechanisms.
Topics: Adult; Australia; Case-Control Studies; Depression; Female; Humans; Male; Methadone; Middle Aged; Na | 2008 |
Obstructive sleep apnea is more common than central sleep apnea in methadone maintenance patients with subjective sleep complaints.
Topics: Adult; Body Mass Index; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Diso | 2010 |
Severe central sleep apnea in a child with leukemia on chronic methadone therapy.
Topics: Analgesics, Opioid; Child; Humans; Leukemia, Myeloid, Acute; Male; Methadone; Pain; Severity of Illn | 2013 |
[Methadone and sleep apnea syndrome].
Topics: Adult; Brain; Clonidine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Drug Administr | 2005 |
Central sleep apnea in stable methadone maintenance treatment patients.
Topics: Adult; Female; Heroin Dependence; Humans; Hypercapnia; Hypoxia; Male; Methadone; Narcotics; Polysomn | 2005 |
Sleep-disordered breathing in stable methadone programme patients: a pilot study.
Topics: Adult; Body Mass Index; Case-Control Studies; Depression; Female; Health Status; Heroin Dependence; | 2001 |