methadone has been researched along with Serotonin Syndrome in 8 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Serotonin Syndrome: An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A patient was seen on the palliative care service at our institution who developed serotonin syndrome and mutism associated with methadone use." | 7.73 | A case of serotonin syndrome and mutism associated with methadone. ( Bush, E; Friedman, I; Miller, C, 2006) |
| "Serotonin syndrome is a syndrome identified by a triad of altered mental status, neuromuscular overactivity, and autonomic instability caused by the overstimulation of serotonin in the central nervous system and periphery." | 5.42 | Serotonin syndrome caused by fentanyl and methadone in a burn injury. ( Gala, G; Hillman, AD; Sultan, SM; Witenko, CJ, 2015) |
| "Methadone has additional pharmacologic and toxicologic properties which may complicate the assessment and treatment in overdose situations." | 5.35 | A case of serotonin syndrome associated with methadone overdose. ( Martinez, DN; Martinez, TT, 2008) |
| "A patient was seen on the palliative care service at our institution who developed serotonin syndrome and mutism associated with methadone use." | 3.73 | A case of serotonin syndrome and mutism associated with methadone. ( Bush, E; Friedman, I; Miller, C, 2006) |
| "Serotonin syndrome is a syndrome identified by a triad of altered mental status, neuromuscular overactivity, and autonomic instability caused by the overstimulation of serotonin in the central nervous system and periphery." | 1.42 | Serotonin syndrome caused by fentanyl and methadone in a burn injury. ( Gala, G; Hillman, AD; Sultan, SM; Witenko, CJ, 2015) |
| "Methadone has additional pharmacologic and toxicologic properties which may complicate the assessment and treatment in overdose situations." | 1.35 | A case of serotonin syndrome associated with methadone overdose. ( Martinez, DN; Martinez, TT, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mastroianni, A | 1 |
| Ravaglia, G | 1 |
| Hillman, AD | 1 |
| Witenko, CJ | 1 |
| Sultan, SM | 1 |
| Gala, G | 2 |
| Atkinson, TJ | 1 |
| Fudin, J | 1 |
| Pham, TC | 1 |
| Hillman, A | 1 |
| Witenko, C | 1 |
| Sultan, S | 1 |
| Zhang, XC | 1 |
| Siket, M | 1 |
| Binder, W | 1 |
| Martinez, TT | 1 |
| Martinez, DN | 1 |
| Rastogi, R | 1 |
| Swarm, RA | 1 |
| Patel, TA | 1 |
| Rachid, F | 1 |
| Golaz, J | 1 |
| Bondolfi, G | 1 |
| Bertschy, G | 1 |
| Bush, E | 1 |
| Miller, C | 1 |
| Friedman, I | 1 |
2 reviews available for methadone and Serotonin Syndrome
| Article | Year |
|---|---|
Serotonin syndrome due to co-administration of linezolid and methadone.
Topics: Adult; Anti-HIV Agents; Drug Synergism; Drug Therapy, Combination; HIV Infections; Humans; Linezolid | 2017 |
Case scenario: opioid association with serotonin syndrome: implications to the practitioners.
Topics: Analgesics, Opioid; Antidepressive Agents, Tricyclic; Celecoxib; Chronic Pain; Cyclooxygenase 2 Inhi | 2011 |
6 other studies available for methadone and Serotonin Syndrome
| Article | Year |
|---|---|
Serotonin syndrome caused by fentanyl and methadone in a burn injury.
Topics: Adult; Analgesics, Opioid; Burns; Drug Interactions; Drug Therapy, Combination; Fentanyl; Humans; Ma | 2015 |
Combined fentanyl and methadone induced serotonin syndrome is called into question.
Topics: Analgesics, Opioid; Burns; Fentanyl; Humans; Male; Methadone; Serotonin Syndrome | 2015 |
The pharma-fever that almost got away.
Topics: Acetaminophen; Aged; Analgesics, Opioid; Antipyretics; Carcinoma, Non-Small-Cell Lung; Drug Overdose | 2016 |
A case of serotonin syndrome associated with methadone overdose.
Topics: Adult; Cyclohexanols; Drug Overdose; Humans; Male; Methadone; Selective Serotonin Reuptake Inhibitor | 2008 |
Induction of a mixed depressive episode during rTMS treatment in a patient with refractory major depression.
Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Antidepressive | 2006 |
A case of serotonin syndrome and mutism associated with methadone.
Topics: Aged; Female; Humans; Methadone; Mutism; Narcotics; Palliative Care; Serotonin Syndrome; United Stat | 2006 |