methadone has been researched along with Sensitivity and Specificity in 88 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Our objective was to compare mortality rates among patients who received prescribed methadone or long-acting morphine for pain." | 7.77 | Comparative mortality among Department of Veterans Affairs patients prescribed methadone or long-acting morphine for chronic pain. ( Bair, MJ; Becker, WC; Hui, S; Krebs, EE; McCoy, K; Zerzan, J, 2011) |
| " Our objective was to compare mortality rates among patients who received prescribed methadone or long-acting morphine for pain." | 3.77 | Comparative mortality among Department of Veterans Affairs patients prescribed methadone or long-acting morphine for chronic pain. ( Bair, MJ; Becker, WC; Hui, S; Krebs, EE; McCoy, K; Zerzan, J, 2011) |
| "The authors refer to their experience with alternative matrices to supervise the methadone therapy of heroin abusers." | 3.74 | Methadone in hair and sweat from patients in long-term maintenance therapy. ( De Giovanni, N; Fucci, N, 2007) |
| "The object of this study was to determine the sensitivity and specificity of the Cozart RapiScan onsite saliva test for methadone and opiates versus laboratory-based enzyme immunoassay (EIA) and gas chromatography-mass spectrometry (GC-MS) confirmation." | 3.71 | Gas chromatography-mass spectrometry confirmation of Cozart RapiScan saliva methadone and opiates tests. ( Holgate, R; Moore, L; Spiehler, V; Wicks, J, 2001) |
| "Methadone maintenance treatment (MMT) has been used as a treatment for opiate dependence since the mid-1960s." | 2.82 | Quantitative EEG and Low-Resolution Electromagnetic Tomography (LORETA) Imaging of Patients Undergoing Methadone Treatment for Opiate Addiction. ( Kydd, RR; Russell, BR; Wang, GY, 2016) |
| "To perform a quantitative trait locus association for identifying genetic variants for MMT dosage that underlie heroin addiction and methadone metabolism and then integrate several genotypic and phenotypic factors are potential predictors for clinically optimal MMT dose for personalized prescription." | 1.56 | Precision therapeutic opioid dosing implications from genetic biomarkers and craving score. ( Chang, HW; Ho, WC; Huang, CL; Wang, RY, 2020) |
| " The data suggest that the assay is well suited for pharmacokinetic purposes." | 1.51 | Enantioselective capillary electrophoresis for pharmacokinetic analysis of methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine in equines anesthetized with ketamine and isoflurane. ( Braun, C; Gittel, C; Larenza Menzies, MP; Sandbaumhüter, FA; Theurillat, R; Thormann, W, 2019) |
| "Methadone-d9 was used as internal standard for the determination of MDN and EMDP, while EDDP-d3 for EDDP." | 1.35 | Validated method for the simultaneous determination of methadone and its main metabolites (EDDP and EMDP) in plasma of umbilical cord blood by gas chromatography-mass spectrometry. ( Athanaselis, SA; Atta-Politou, J; Calokerinos, AC; Maravelias, CP; Nikolaou, PD; Papoutsis, II; Spiliopoulou, CA, 2008) |
| " With time the dosing often increases because of tolerance." | 1.32 | Methadone dosage for prevention of opioid withdrawal in children. ( Cimino, M; Fletcher, JE; Heard, AM; Heard, CM; Kielma, D; Siddappa, R, 2003) |
| "Methadone (MTD) is a chiral drug widely used for the treatment of opioid dependence for which a rapid analytical method for the determination of each enantiomer would be advantageous." | 1.32 | Automated LC-MS method for the fast stereoselective determination of methadone in plasma. ( Eap, C; Rudaz, S; Souverain, S; Veuthey, JL, 2003) |
| " MTD excretion was higher in men, decreased with increased urinary pH, and increased with daily dosage of MTD; these factors explain 32% of the total variance of urinary MTD." | 1.32 | Compliance with methadone-based substitutive treatment: a proposed model based on immunoassay urinary sample screening. ( Bézie, Y; Billaud, E; Boutouyrie, P; Illier, C; Lillo, A; Prognon, P; Talon, V, 2004) |
| "Methadone is a 50:50 mixture of two enantiomers and (R)-methadone accounts for the majority of its opioid effect." | 1.31 | Plasma concentrations of the enantiomers of methadone and therapeutic response in methadone maintenance treatment. ( Baumann, P; Bourquin, M; Déglon, J; Eap, CB; Livoti, S; Martin, J; Powell, K; Spagnoli, J, 2000) |
| "Methadone is a potent analgesic and sedative." | 1.31 | Determination of methadone in urine using ion trap GC/MS in positive ion chemical ionization mode. ( Guzaldo, F; Hussain, MJ; Lewis, D; Moore, C, 2001) |
| "Methadone was also found to block I(K) in GH3 cells and in chick myoblasts." | 1.29 | Methadone block of K+ current in squid giant fiber lobe neurons. ( Gilly, WF; Horrigan, FT, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (14.77) | 18.2507 |
| 2000's | 51 (57.95) | 29.6817 |
| 2010's | 19 (21.59) | 24.3611 |
| 2020's | 5 (5.68) | 2.80 |
| Authors | Studies |
|---|---|
| Xue, W | 1 |
| Tan, X | 1 |
| Khaing Oo, MK | 1 |
| Kulkarni, G | 1 |
| Ilgen, MA | 1 |
| Fan, X | 1 |
| Wakeman, SE | 1 |
| Pelletti, G | 1 |
| Rossi, F | 1 |
| Garagnani, M | 1 |
| Barone, R | 1 |
| Roffi, R | 1 |
| Fais, P | 1 |
| Pelotti, S | 1 |
| Chang, HW | 1 |
| Ho, WC | 1 |
| Huang, CL | 1 |
| Wang, RY | 1 |
| Livingston, KE | 1 |
| Mahoney, JP | 1 |
| Manglik, A | 1 |
| Sunahara, RK | 1 |
| Traynor, JR | 1 |
| Picht, F | 1 |
| Beck, O | 2 |
| Böttcher, M | 1 |
| Theurillat, R | 1 |
| Sandbaumhüter, FA | 1 |
| Gittel, C | 1 |
| Larenza Menzies, MP | 1 |
| Braun, C | 1 |
| Thormann, W | 1 |
| Davari, B | 1 |
| Kotecha, N | 1 |
| Clavijo, CF | 1 |
| Thomas, JJ | 1 |
| Rzasa-Lynn, R | 1 |
| Galinkin, JL | 1 |
| Christians, U | 1 |
| Sempio, C | 1 |
| Winklhofer, S | 1 |
| Surer, E | 1 |
| Ampanozi, G | 1 |
| Ruder, T | 1 |
| Stolzmann, P | 1 |
| Elliott, M | 1 |
| Oestreich, A | 1 |
| Kraemer, T | 1 |
| Thali, M | 1 |
| Alkadhi, H | 1 |
| Schweitzer, W | 1 |
| Carlsson, S | 1 |
| Tusic, M | 1 |
| Olsson, R | 1 |
| Franzen, L | 1 |
| Hulten, P | 1 |
| Kyle, AR | 1 |
| Carmical, J | 1 |
| Shah, D | 1 |
| Pryor, J | 1 |
| Brown, S | 1 |
| Wang, GY | 2 |
| Kydd, RR | 1 |
| Russell, BR | 1 |
| Beck, R | 1 |
| Carter, P | 1 |
| Shonsey, E | 1 |
| Graves, D | 1 |
| Doborjeh, MG | 1 |
| Kasabov, NK | 1 |
| Kydd, R | 1 |
| Russell, B | 1 |
| Kim, SY | 1 |
| Kim, H | 1 |
| Park, Y | 1 |
| Lim, J | 1 |
| Kim, J | 1 |
| Koo, SH | 1 |
| Kwon, GC | 1 |
| Prommer, EE | 1 |
| Marin, SJ | 1 |
| Keith, L | 1 |
| Merrell, M | 1 |
| McMillin, GA | 1 |
| de Castro, A | 1 |
| Concheiro, M | 1 |
| Shakleya, DM | 2 |
| Huestis, MA | 7 |
| Varenbut, M | 2 |
| Plater-Zyberk, CJ | 1 |
| Worster, A | 2 |
| Daiter, J | 2 |
| Gosselin, M | 1 |
| Ramirez Fernandez, Mdel M | 1 |
| Wille, SM | 1 |
| Samyn, N | 1 |
| De Boeck, G | 1 |
| Bourel, B | 1 |
| Dowling, G | 1 |
| Regan, L | 1 |
| Tierney, J | 1 |
| Nangle, M | 1 |
| Kirschbaum, KM | 2 |
| Musshoff, F | 2 |
| Wilbert, A | 1 |
| Röhrich, J | 1 |
| Madea, B | 2 |
| Krebs, EE | 1 |
| Becker, WC | 1 |
| Zerzan, J | 1 |
| Bair, MJ | 1 |
| McCoy, K | 1 |
| Hui, S | 1 |
| Schmithausen, R | 1 |
| Stockhausen, S | 1 |
| Lopez-Avila, V | 1 |
| Cooley, J | 1 |
| Urdahl, R | 1 |
| Thevis, M | 1 |
| Ahmadi, F | 1 |
| Rezaei, H | 1 |
| Tahvilian, R | 1 |
| Agius, R | 1 |
| Nadulski, T | 1 |
| Kahl, HG | 1 |
| Dufaux, B | 1 |
| Ho, TS | 1 |
| Pedersen-Bjergaard, S | 1 |
| Rasmussen, KE | 1 |
| Kellogg, SH | 1 |
| Ho, A | 1 |
| Bell, K | 1 |
| Schluger, RP | 1 |
| McHugh, PF | 1 |
| McClary, KA | 1 |
| Kreek, MJ | 1 |
| Shiran, MR | 1 |
| Gregory, A | 1 |
| Rostami-Hodjegan, A | 1 |
| Tucker, GT | 1 |
| Lennard, MS | 1 |
| Rentsch, KM | 1 |
| Rosas, ME | 1 |
| Preston, KL | 4 |
| Epstein, DH | 1 |
| Moolchan, ET | 1 |
| Wainer, IW | 2 |
| Siddappa, R | 1 |
| Fletcher, JE | 1 |
| Heard, AM | 1 |
| Kielma, D | 1 |
| Cimino, M | 1 |
| Heard, CM | 1 |
| Liang, HR | 2 |
| Foltz, RL | 2 |
| Meng, M | 2 |
| Bennett, P | 2 |
| Souverain, S | 1 |
| Eap, C | 1 |
| Veuthey, JL | 4 |
| Rudaz, S | 4 |
| Bézie, Y | 1 |
| Talon, V | 1 |
| Lillo, A | 1 |
| Illier, C | 1 |
| Billaud, E | 1 |
| Prognon, P | 1 |
| Boutouyrie, P | 1 |
| Whittington, D | 1 |
| Sheffels, P | 1 |
| Kharasch, ED | 1 |
| Vanagas, G | 1 |
| Padaiga, Z | 1 |
| Subata, E | 1 |
| Choo, RE | 2 |
| Murphy, CM | 1 |
| Jones, HE | 1 |
| He, H | 1 |
| Sun, C | 1 |
| Wang, XR | 1 |
| Pham-Huy, C | 2 |
| Chikhi-Chorfi, N | 2 |
| Galons, H | 2 |
| Thevenin, M | 2 |
| Claude, JR | 2 |
| Warnet, JM | 2 |
| Hallinan, R | 1 |
| Ray, J | 1 |
| Byrne, A | 1 |
| Agho, K | 1 |
| Attia, J | 1 |
| Cooper, G | 2 |
| Wilson, L | 2 |
| Reid, C | 2 |
| Baldwin, D | 2 |
| Hand, C | 2 |
| Spiehler, V | 3 |
| Etter, ML | 1 |
| George, S | 1 |
| Graybiel, K | 1 |
| Eichhorst, J | 1 |
| Lehotay, DC | 1 |
| Quintela, O | 1 |
| López, P | 1 |
| Bermejo, AM | 2 |
| López-Rivadulla, M | 1 |
| Rodriguez-Rosas, ME | 1 |
| Lofwall, MR | 1 |
| Strain, EC | 1 |
| Siluk, D | 1 |
| Valentová, J | 1 |
| Horáková, R | 1 |
| Pechová, I | 1 |
| Okruhlica, L | 1 |
| Devínsky, F | 1 |
| Jansson, LM | 2 |
| Scheidweiler, K | 1 |
| Swaminathan, S | 1 |
| Schoenbaum, EE | 1 |
| Klein, RS | 1 |
| Howard, AA | 1 |
| Lo, Y | 1 |
| Gourevitch, MN | 1 |
| Fucci, N | 1 |
| De Giovanni, N | 1 |
| Schappler, J | 1 |
| Guillarme, D | 1 |
| Prat, J | 1 |
| El-Beqqali, A | 1 |
| Abdel-Rehim, M | 1 |
| Kelly, T | 1 |
| Doble, P | 1 |
| Dawson, M | 1 |
| Teplin, D | 1 |
| Raz, B | 1 |
| Martins, LF | 1 |
| Yegles, M | 1 |
| Wennig, R | 1 |
| Nanovskaya, TN | 1 |
| Nekhayeva, IA | 1 |
| Hankins, GD | 1 |
| Ahmed, MS | 1 |
| Nikolaou, PD | 1 |
| Papoutsis, II | 1 |
| Atta-Politou, J | 1 |
| Athanaselis, SA | 1 |
| Spiliopoulou, CA | 1 |
| Calokerinos, AC | 1 |
| Maravelias, CP | 1 |
| Raistrick, D | 1 |
| Bradshaw, J | 1 |
| Tober, G | 1 |
| Weiner, J | 1 |
| Allison, J | 1 |
| Healey, C | 1 |
| Brewer, C | 1 |
| Kristensen, K | 2 |
| Angelo, HR | 2 |
| Blemmer, T | 1 |
| Horrigan, FT | 1 |
| Gilly, WF | 1 |
| Dessalles, MC | 1 |
| Gasdeblay, S | 1 |
| Mahuzier, G | 1 |
| Verweij, AM | 1 |
| Hordijk, ML | 1 |
| Lipman, PJ | 1 |
| Manji, H | 1 |
| Chen, G | 1 |
| Potter, W | 1 |
| Kosten, TR | 1 |
| Brown, ER | 1 |
| Jarvie, DR | 1 |
| Simpson, D | 1 |
| Galloway, JH | 1 |
| Ashford, M | 1 |
| Marsh, ID | 1 |
| Holden, M | 1 |
| Forrest, AR | 1 |
| Torrens, M | 1 |
| Castillo, C | 1 |
| San, L | 1 |
| del Moral, E | 1 |
| González, ML | 1 |
| de la Torre, R | 1 |
| Beck, N | 1 |
| Wong, CJ | 2 |
| Umbricht, A | 2 |
| Goldberger, BA | 1 |
| Cone, EJ | 2 |
| Barnett, PG | 2 |
| Sporkert, F | 2 |
| Pragst, F | 2 |
| Lucas, AC | 1 |
| Tabernero, MJ | 1 |
| Fernández, P | 1 |
| Strano-Rossi, S | 1 |
| Ortelli, D | 1 |
| Chevalley, AF | 1 |
| Mino, A | 1 |
| Deglon, JJ | 1 |
| Balant, L | 1 |
| Zaric, GS | 1 |
| Brandeau, ML | 1 |
| Jussila, M | 1 |
| Sinervo, K | 1 |
| Porras, SP | 1 |
| Riekkola, ML | 1 |
| Eap, CB | 1 |
| Bourquin, M | 1 |
| Martin, J | 1 |
| Spagnoli, J | 1 |
| Livoti, S | 1 |
| Powell, K | 1 |
| Baumann, P | 1 |
| Déglon, J | 1 |
| Moore, C | 1 |
| Guzaldo, F | 1 |
| Hussain, MJ | 1 |
| Lewis, D | 1 |
| Happe, HK | 1 |
| Bylund, DB | 1 |
| Murrin, LC | 1 |
| Bovasso, GB | 1 |
| Alterman, AI | 1 |
| Cacciola, JS | 1 |
| Cook, TG | 1 |
| Cherkaoui, S | 1 |
| Varesio, E | 1 |
| Spanbauer, AC | 1 |
| Casseday, S | 1 |
| Davoudzadeh, D | 1 |
| Moore, L | 1 |
| Wicks, J | 1 |
| Holgate, R | 1 |
| Wodak, AD | 1 |
| Hall, WD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of CYP2B6, CYP3A4, and MDR1 in the Metabolic Clearance of Methadone in Human Subjects[NCT00504413] | Phase 1 | 20 participants (Anticipated) | Interventional | 2007-07-31 | Recruiting | ||
| Neurophysiological, Biomolecular and Psychological Aspects of Erenumab Treatment in Chronic Migraine: an Open Label, Hypothesis Generator Study[NCT04361721] | 40 participants (Anticipated) | Observational | 2020-01-15 | Recruiting | |||
| A Randomized Community Intervention Trial on Reducing HIV Infection Among Drug Users Attending Methadone Maintenance Treatment(MMT) and Preventing Secondary Transmission From HIV Positive Clients to Their Sexual Partners in China[NCT01108614] | Phase 3 | 12,000 participants (Anticipated) | Interventional | 2009-06-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for methadone and Sensitivity and Specificity
| Article | Year |
|---|---|
The importance of stereoselective determination of drugs in the clinical laboratory.
Topics: Anesthetics; Anticoagulants; Drug Evaluation; Humans; Methadone; Pharmaceutical Preparations; Pharma | 2002 |
Drug addiction maintenance treatment and quality of life measurements.
Topics: Activities of Daily Living; Humans; Interviews as Topic; Methadone; Narcotics; Pain Measurement; Pat | 2004 |
Hair analysis as a tool for monitoring and managing patients on methadone maintenance. A discussion.
Topics: Hair; Humans; Illicit Drugs; Methadone; Narcotics; Sensitivity and Specificity; Substance Abuse Dete | 1993 |
The cost-effectiveness of methadone maintenance as a health care intervention.
Topics: Adult; Aged; Cohort Studies; Cost-Benefit Analysis; Follow-Up Studies; Heroin Dependence; Humans; Ma | 1999 |
3 trials available for methadone and Sensitivity and Specificity
| Article | Year |
|---|---|
Quantitative EEG and Low-Resolution Electromagnetic Tomography (LORETA) Imaging of Patients Undergoing Methadone Treatment for Opiate Addiction.
Topics: Adult; Analgesics, Opioid; Brain Mapping; Diagnosis, Computer-Assisted; Electroencephalography; Fema | 2016 |
A Spiking Neural Network Methodology and System for Learning and Comparative Analysis of EEG Data From Healthy Versus Addiction Treated Versus Addiction Not Treated Subjects.
Topics: Adult; Brain; Cognition; Diagnosis, Computer-Assisted; Electroencephalography; Female; Humans; Machi | 2016 |
Simultaneous determination of buprenorphine, norbuprenorphine and the enantiomers of methadone and its metabolite (EDDP) in human plasma by liquid chromatography/mass spectrometry.
Topics: Buprenorphine; Calibration; Humans; Mass Spectrometry; Methadone; Reference Standards; Reproducibili | 2007 |
81 other studies available for methadone and Sensitivity and Specificity
| Article | Year |
|---|---|
Rapid and sensitive detection of drugs of abuse in sweat by multiplexed capillary based immuno-biosensors.
Topics: Amphetamine; Biosensing Techniques; Dronabinol; Enzyme-Linked Immunosorbent Assay; Humans; Illicit D | 2020 |
Diagnosis and Treatment of Opioid Use Disorder in 2020.
Topics: Adult; Buprenorphine; Delayed-Action Preparations; Diagnostic and Statistical Manual of Mental Disor | 2020 |
Optimization of cloned enzyme donor immunoassay cut-offs for drugs of abuse in post-mortem whole blood.
Topics: Amphetamines; Cannabinoids; Cocaine; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Huma | 2020 |
Precision therapeutic opioid dosing implications from genetic biomarkers and craving score.
Topics: Adult; Craving; Cytochrome P-450 CYP2B6; Female; Genetic Association Studies; Genetic Markers; Heroi | 2020 |
Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor.
Topics: Allosteric Regulation; Allosteric Site; Biosensing Techniques; Biotin; Humans; Interferometry; Ligan | 2018 |
Evaluation of an on-site test device for the heroin metabolite 6-acetylmorphine in urine.
Topics: Buprenorphine; Codeine; Gas Chromatography-Mass Spectrometry; Heroin; Humans; Methadone; Morphine; M | 2019 |
Enantioselective capillary electrophoresis for pharmacokinetic analysis of methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine in equines anesthetized with ketamine and isoflurane.
Topics: Animals; Drug Interactions; Electrophoresis, Capillary; Horses; Isoflurane; Ketamine; Methadone; Pyr | 2019 |
A Sensitive LC-MS/MS Assay for the Quantification of Methadone and its Metabolites in Dried Blood Spots: Comparison With Plasma.
Topics: Analgesics, Opioid; Chromatography, Liquid; Dried Blood Spot Testing; Drug Monitoring; Humans; Metha | 2020 |
Post-mortem whole body computed tomography of opioid (heroin and methadone) fatalities: frequent findings and comparison to autopsy.
Topics: Adolescent; Adult; Autopsy; Brain Edema; Cardiomegaly; Cause of Death; Female; Forensic Pathology; H | 2014 |
Laboratory and clinical evaluation of on-site urine drug testing.
Topics: Amphetamines; Analgesics, Opioid; Benzodiazepines; Buprenorphine; Cannabinoids; Evaluation Studies a | 2014 |
UHPLC-MS/MS quantification of buprenorphine, norbuprenorphine, methadone, and glucuronide conjugates in umbilical cord plasma.
Topics: Blood Chemical Analysis; Blood Specimen Collection; Buprenorphine; Chromatography, High Pressure Liq | 2015 |
Tandem DART™ MS Methods for Methadone Analysis in Unprocessed Urine.
Topics: Chromatography, Liquid; Gas Chromatography-Mass Spectrometry; Humans; Immunoenzyme Techniques; Limit | 2016 |
Evaluation of an Automated Reader and Color Interpretation-Based Immunoassays for Multiplexed Drug-of-Abuse Testing in Urine.
Topics: Amphetamine; Automation; Buprenorphine; China; Cocaine; Dronabinol; Gas Chromatography-Mass Spectrom | 2017 |
Opioid-induced pain.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; | 2008 |
Comparison of drugs of abuse detection in meconium by EMIT II and ELISA.
Topics: Amphetamines; Analgesics, Opioid; Barbiturates; Benzodiazepines; Cannabinoids; Chromatography, Liqui | 2009 |
Development and validation of a liquid chromatography mass spectrometry assay for the simultaneous quantification of methadone, cocaine, opiates and metabolites in human umbilical cord.
Topics: Chromatography, Liquid; Cocaine; Drug Stability; Female; Humans; Least-Squares Analysis; Mass Spectr | 2009 |
Does low urine creatinine level indicate the presence of urine alcohol in methadone maintenance treatment patients?
Topics: Analgesics, Opioid; Biomarkers, Pharmacological; Creatinine; Ethanol; Humans; Medical Records; Metha | 2010 |
Quantification of methadone and its metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine in third instar larvae of Lucilia sericata (Diptera: Calliphoridae) using liquid chromatography-tandem mass spectrometry.
Topics: Animals; Chromatography, Liquid; Diptera; Forensic Medicine; Humans; Larva; Methadone; Narcotics; Py | 2010 |
A hybrid liquid chromatography-mass spectrometry strategy in a forensic laboratory for opioid, cocaine and amphetamine classes in human urine using a hybrid linear ion trap-triple quadrupole mass spectrometer.
Topics: Amphetamines; Calibration; Chromatography, Liquid; Cocaine; Humans; Linear Models; Mass Spectrometry | 2010 |
Direct ELISA kits as a sensitive and selective screening method for abstinence control in urine.
Topics: Amphetamines; Automobile Driving; Benzodiazepines; Cocaine; Enzyme-Linked Immunosorbent Assay; Gas C | 2011 |
Comparative mortality among Department of Veterans Affairs patients prescribed methadone or long-acting morphine for chronic pain.
Topics: Adult; Aged; Analgesics, Opioid; Benzodiazepines; Cohort Studies; Drug Delivery Systems; Female; Hum | 2011 |
Optimization and validation of CEDIA drugs of abuse immunoassay tests in serum on Hitachi 912.
Topics: Amphetamines; Autoanalysis; Cannabinoids; Chromatography, Liquid; Cocaine; Cohort Studies; Female; F | 2011 |
Determination of stimulants using gas chromatography/high-resolution time-of-flight mass spectrometry and a soft ionization source.
Topics: Caffeine; Central Nervous System Stimulants; Cocaine; Codeine; Dopamine Uptake Inhibitors; Equipment | 2012 |
Computational-aided design of molecularly imprinted polymer for selective extraction of methadone from plasma and saliva and determination by gas chromatography.
Topics: Adsorption; Chromatography, Gas; Computer-Aided Design; Humans; Hydrogen-Ion Concentration; Linear M | 2012 |
Comparison of LUCIO®-direct ELISA with CEDIA immunoassay for 'zero tolerance' drug screening in urine as required by the German re-licensing guidelines.
Topics: Amphetamines; Analgesics, Opioid; Benzodiazepines; Cannabinoids; Cocaine; Enzyme-Linked Immunosorben | 2013 |
Recovery, enrichment and selectivity in liquid-phase microextraction comparison with conventional liquid-liquid extraction.
Topics: Chromatography, Gas; Chromatography, Liquid; Electrophoresis, Capillary; Humans; Methadone; Prometha | 2002 |
The Personality Assessment Inventory Drug Problems Scale: a validity analysis.
Topics: Adult; Female; Humans; Male; Methadone; New York City; Opioid-Related Disorders; Personality Invento | 2002 |
Determination of midazolam and 1'-hydroxymidazolam by liquid chromatography-mass spectrometry in plasma of patients undergoing methadone maintenance treatment.
Topics: Adjuvants, Anesthesia; Anti-Anxiety Agents; Chromatography, Liquid; Humans; Mass Spectrometry; Metha | 2003 |
Quantitative determination of the enantiomers of methadone and its metabolite (EDDP) in human saliva by enantioselective liquid chromatography with mass spectrometric detection.
Topics: Chromatography, Liquid; Humans; Hydrogen-Ion Concentration; Mass Spectrometry; Methadone; Reference | 2003 |
Methadone dosage for prevention of opioid withdrawal in children.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; F | 2003 |
Ionization enhancement in atmospheric pressure chemical ionization and suppression in electrospray ionization between target drugs and stable-isotope-labeled internal standards in quantitative liquid chromatography/tandem mass spectrometry.
Topics: Artifacts; Calibration; Chromatography, Liquid; Flow Injection Analysis; Fructose; Humans; Isotope L | 2003 |
Automated LC-MS method for the fast stereoselective determination of methadone in plasma.
Topics: Analgesics, Opioid; Chromatography, Liquid; Humans; Mass Spectrometry; Methadone; Reference Standard | 2003 |
Compliance with methadone-based substitutive treatment: a proposed model based on immunoassay urinary sample screening.
Topics: Adult; Cross-Sectional Studies; Enzyme Multiplied Immunoassay Technique; Female; Humans; Hydrogen-Io | 2004 |
Method development and validation for quantitative determination of methadone enantiomers in human plasma by liquid chromatography/tandem mass spectrometry.
Topics: Calibration; Chromatography, Liquid; Humans; Methadone; Reference Standards; Reproducibility of Resu | 2004 |
Stereoselective determination of methadone and the primary metabolite EDDP in human plasma by automated on-line extraction and liquid chromatography mass spectrometry.
Topics: Automation; Chromatography, Liquid; Humans; Mass Spectrometry; Methadone; Pyrrolidines; Sensitivity | 2004 |
Determination of methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, 2-ethyl-5-methyl-3,3-diphenylpyraline and methadol in meconium by liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry.
Topics: Atmospheric Pressure; Humans; Mass Spectrometry; Meconium; Methadone; Pyrrolidines; Reproducibility | 2005 |
Solid-phase extraction of methadone enantiomers and benzodiazepines in biological fluids by two polymeric cartridges for liquid chromatographic analysis.
Topics: Animals; Benzodiazepines; Chromatography, High Pressure Liquid; Humans; Methadone; Polymers; Rabbits | 2005 |
Therapeutic thresholds in methadone maintenance treatment: a receiver operating characteristic analysis.
Topics: Adult; Area Under Curve; Differential Threshold; Female; Humans; Male; Methadone; Narcotics; Odds Ra | 2006 |
Comparison of GC-MS and EIA results for the analysis of methadone in oral fluid.
Topics: Female; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Humans; Immunoenzyme Techniques; Ma | 2005 |
Determination of free and protein-bound methadone and its major metabolite EDDP: enantiomeric separation and quantitation by LC/MS/MS.
Topics: Chromatography, Liquid; Humans; Linear Models; Mass Spectrometry; Methadone; Molecular Structure; Pr | 2005 |
Comparison of Cozart microplate ELISA and GC-MS detection of methadone and metabolites in human hair.
Topics: Enzyme-Linked Immunosorbent Assay; False Negative Reactions; False Positive Reactions; Forensic Medi | 2005 |
Determination of methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine and alprazolam in human plasma by liquid chromatography-electrospray ionization mass spectrometry.
Topics: Alprazolam; Calibration; Chromatography, Liquid; Humans; Methadone; Pyrrolidines; Reproducibility of | 2006 |
Stereoselective determination of methadone and its main metabolite in serum and urine from methadone maintenance patients.
Topics: Adult; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Humans; Male; | 2006 |
A validated liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometric method for the quantification of methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), and 2-Ethyl-5-methyl-3,3-diphenylpyroline (EMDP) in
Topics: Chromatography, Liquid; Female; Humans; Lactation; Methadone; Milk, Human; Narcotics; Pyrrolidines; | 2007 |
Two-step tuberculin skin testing in drug users.
Topics: Adult; AIDS-Related Opportunistic Infections; Alcoholism; CD4 Lymphocyte Count; Comorbidity; Female; | 2007 |
Validation of a LC-APCI-MS/MS method for quantification of methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-diphenylpyraline (EMDP) in infant plasma following protein precipitation.
Topics: Blood Proteins; Chemical Precipitation; Chromatography, Liquid; Humans; Infant; Methadone; Pyrrolidi | 2007 |
Methadone in hair and sweat from patients in long-term maintenance therapy.
Topics: Adult; Drug Monitoring; Female; Gas Chromatography-Mass Spectrometry; Hair; Heroin Dependence; Human | 2007 |
Coupling CE with atmospheric pressure photoionization MS for pharmaceutical basic compounds: optimization of operating parameters.
Topics: Atmospheric Pressure; Electrophoresis, Capillary; Methadone; N-Methyl-3,4-methylenedioxyamphetamine; | 2007 |
Quantitative analysis of methadone in human urine samples by microextraction in packed syringe-gas chromatography-mass spectrometry (MEPS-GC-MS).
Topics: Amides; Calibration; Chemistry, Pharmaceutical; Cyclophosphamide; Drug Monitoring; Gas Chromatograph | 2007 |
A fast CE method for the achiral separation of methadone and its major metabolites, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine and 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline.
Topics: Calibration; Coated Materials, Biocompatible; Dextran Sulfate; Electrophoresis, Capillary; Forensic | 2007 |
Diagnostic value of self-report of alcohol use in patients enrolled in a methadone maintenance treatment program (MMTP).
Topics: Alcoholism; Cohort Studies; Humans; Methadone; Narcotics; Opioid-Related Disorders; Retrospective St | 2007 |
Simultaneous enantioselective quantification of methadone and of 2-ethylidene-1,5-dimethyl-3,3-diphenyl-pyrrolidine in oral fluid using capillary electrophoresis.
Topics: Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentration; Methadone; Pyrrolidines; Reproducibi | 2008 |
Transfer of methadone across the dually perfused preterm human placental lobule.
Topics: Female; Gestational Age; Humans; Maternal-Fetal Exchange; Methadone; Organ Culture Techniques; Perfu | 2008 |
Validated method for the simultaneous determination of methadone and its main metabolites (EDDP and EMDP) in plasma of umbilical cord blood by gas chromatography-mass spectrometry.
Topics: Calibration; Fetal Blood; Gas Chromatography-Mass Spectrometry; Humans; Methadone; Reproducibility o | 2008 |
Development of the Leeds Dependence Questionnaire (LDQ): a questionnaire to measure alcohol and opiate dependence in the context of a treatment evaluation package.
Topics: Adult; Alcoholism; Female; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders; Pilot Pro | 1994 |
Enantioselective high-performance liquid chromatographic method for the determination of methadone in serum using an AGP and a CN column as chiral and analytical column, respectively.
Topics: Chromatography, High Pressure Liquid; Humans; Methadone; Sensitivity and Specificity; Stereoisomeris | 1994 |
Methadone block of K+ current in squid giant fiber lobe neurons.
Topics: Analgesics, Opioid; Animals; Cells, Cultured; Chick Embryo; Decapodiformes; Dextropropoxyphene; Elec | 1996 |
[Determination of serum methadone with an immunologic kit and comparison with a liquid chromatography method].
Topics: Chromatography, Liquid; Fluorescence Polarization Immunoassay; Humans; Methadone; Reagent Kits, Diag | 1996 |
Liquid chromatographic-thermospray tandem mass spectrometric quantitative analysis of some drugs with hypnotic, sedative and tranquillising properties in whole blood.
Topics: Benzodiazepines; Butyrophenones; Calibration; Chromatography, High Pressure Liquid; Humans; Mass Spe | 1996 |
Guanine nucleotide binding proteins in opioid-dependent patients.
Topics: Adenosine Diphosphate Ribose; Adult; Blood Platelets; Cell Membrane; Female; GTP-Binding Protein alp | 1997 |
Evaluation of Bionike one-step tests for the detection of drugs of abuse in urine.
Topics: Amphetamine; Benzodiazepines; Cannabinoids; Chemistry, Clinical; Chromatography, Gas; Diagnostic Tes | 1997 |
A method for the confirmation and identification of drugs of misuse in urine using solid phase extraction and gas-liquid chromatography with mass spectrometry.
Topics: Codeine; Gas Chromatography-Mass Spectrometry; Humans; Illicit Drugs; Methadone; Morphine; Morphine | 1998 |
Plasma methadone concentrations as an indicator of opioid withdrawal symptoms and heroin use in a methadone maintenance program.
Topics: Adult; Dose-Response Relationship, Drug; Female; Heroin Dependence; Humans; Male; Methadone; Middle | 1998 |
Enantioselective high-performance liquid chromatographic method for the determination of methadone and its main metabolite in urine using an AGP and a C8 column coupled serially.
Topics: Chromatography, High Pressure Liquid; Humans; Methadone; Pain; Reproducibility of Results; Sensitivi | 1999 |
Monitoring cocaine use in substance-abuse-treatment patients by sweat and urine testing.
Topics: Adolescent; Adult; Aged; Cocaine; Cocaine-Related Disorders; Enzyme Multiplied Immunoassay Technique | 1999 |
Use of headspace solid-phase microextraction (HS-SPME) in hair analysis for organic compounds.
Topics: Antidepressive Agents, Tricyclic; Cannabinoids; Chlormethiazole; Diphenhydramine; Gas Chromatography | 2000 |
Use of solid-phase microextraction (SPME) for the determination of methadone and EDDP in human hair by GC-MS.
Topics: Calibration; Gas Chromatography-Mass Spectrometry; Humans; Methadone; Pyrrolidines; Reproducibility | 2000 |
Enantioselective analysis of methadone in saliva by liquid chromatography-mass spectrometry.
Topics: Chromatography, Liquid; Humans; Mass Spectrometry; Methadone; Reproducibility of Results; Saliva; Se | 2000 |
HIV transmission and the cost-effectiveness of methadone maintenance.
Topics: Adult; Analgesics, Opioid; Cost-Benefit Analysis; Health Care Costs; Heroin Dependence; HIV Infectio | 2000 |
Modified liquid junction interface for nonaqueous capillary electrophoresis-mass spectrometry.
Topics: Codeine; Electrophoresis, Capillary; Equipment Design; Indicators and Reagents; Levorphanol; Methado | 2000 |
Monitoring opiate use in substance abuse treatment patients with sweat and urine drug testing.
Topics: Adolescent; Adult; Aged; Enzyme Multiplied Immunoassay Technique; Enzyme-Linked Immunosorbent Assay; | 2000 |
Plasma concentrations of the enantiomers of methadone and therapeutic response in methadone maintenance treatment.
Topics: Adult; Drug Administration Schedule; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid | 2000 |
Determination of methadone and its metabolites EDDP and EMDP in human hair by headspace solid-phase microextraction and gas chromatography-mass spectrometry.
Topics: Adsorption; Calibration; Gas Chromatography-Mass Spectrometry; Hair; Humans; Methadone; Pyrrolidines | 2000 |
Selective antibodies to methadone enantiomers: synthesis of (R)- and (R,S)-methadone conjugates and determination by an immunoenzymatic method in human serum.
Topics: Animals; Antibody Specificity; Cattle; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Humans; M | 2001 |
Determination of methadone in urine using ion trap GC/MS in positive ion chemical ionization mode.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Methadone; Narcotics; Sensitivity and Specificity; Sub | 2001 |
Agonist-stimulated [35S]GTPgammaS autoradiography: optimization for high sensitivity.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Animals; Autoradiography; Binding, Compet | 2001 |
Predictive validity of the Addiction Severity Index's composite scores in the assessment of 2-year outcomes in a methadone maintenance population.
Topics: Adult; Female; Humans; Interview, Psychological; Logistic Models; Male; Methadone; Opioid-Related Di | 2001 |
On-line capillary electrophoresis-electrospray mass spectrometry for the stereoselective analysis of drugs and metabolites.
Topics: Amphetamines; Cyclodextrins; Cyclohexanols; Electrophoresis, Capillary; Indicators and Reagents; Met | 2001 |
Detection of opiate use in a methadone maintenance treatment population with the CEDIA 6-acetylmorphine and CEDIA DAU opiate assays.
Topics: Adolescent; Adult; Cocaine-Related Disorders; Codeine; False Positive Reactions; Female; Gas Chromat | 2001 |
Gas chromatography-mass spectrometry confirmation of Cozart RapiScan saliva methadone and opiates tests.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Immunoenzyme Techniques; Methadone; Narcotics; Saliva; | 2001 |
Buprenorphine: better late than never.
Topics: Australia; Buprenorphine; Female; Follow-Up Studies; Heroin; Humans; Male; Methadone; Narcotic Antag | 2001 |