methadone has been researched along with Seizures in 27 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the frequency of seizures associated with acepromazine administration when used as a premedicant with methadone for dogs undergoing myelography." | 7.78 | Incidence of seizures associated with the use of acepromazine in dogs undergoing myelography. ( Drynan, EA; Gray, P; Raisis, AL, 2012) |
| "Naloxone was without epileptogenic properties in animals that had not been pretreated with methadone." | 5.26 | Naloxone-induced electrographic seizures in the primate. ( Beck, EC; Dustmann, RE; Shearer, DE; Snyder, EW, 1980) |
| "We report here 2 cases of methadone induced Torsades de Pointes with a clinical presentation mimicking convulsive seizures in a substance abuser." | 3.83 | When a seizure is not a real seizure! ( Chaudhari, S; Ghobadi, F; Gracia, E; Hassen, GW; Olatunde, O; Pekler, G; Talebi, S; Visco, F, 2016) |
| "To investigate the frequency of seizures associated with acepromazine administration when used as a premedicant with methadone for dogs undergoing myelography." | 3.78 | Incidence of seizures associated with the use of acepromazine in dogs undergoing myelography. ( Drynan, EA; Gray, P; Raisis, AL, 2012) |
| "Cortical application of morphine (25, 100 and 400 micrograms) induced cortical spikes in a dose-related fashion and, at 400 micrograms, behavioral and electrographic seizures." | 3.67 | Nonspecific convulsions are induced by morphine but not D-Ala2-methionine-enkephalinamide at cortical sites. ( Frenk, H; Mayer, DJ; Miller, J; Watkins, LR, 1984) |
| "BACKGROUND Stress cardiomyopathy (SCM) is a transient dysfunction of the left ventricle due to physical or emotional triggers that produces a range of electrocardiogram (ECG) changes." | 1.51 | Diffuse Deep T-Wave Inversions Following a Generalized Seizure. ( Oleynick, C; Prosperi-Porta, G, 2019) |
| "Methadone is a synthetic opioid used to treat opiate withdrawal and addiction." | 1.51 | Methadone's effects on pentylenetetrazole-induced seizure threshold in mice: NMDA/opioid receptors and nitric oxide signaling. ( Aghaei, I; Bahramnejad, E; Dehpour, AR; Kazemi Roodsari, S; Rahimi, N, 2019) |
| "We present a case of seizure activity in a woman in whom EKG led to a diagnosis of intermittent monomorphic and polymorphic ventricular tachycardia (torsades de pointes), highlighting the need for careful consideration of alternative causes of seizures, even in patients with known epilepsy." | 1.46 | Ventricular tachycardia and prolonged QT interval presenting as seizure-like activity. ( Mitchell, SH; Morris, SC; Wentlandt, M, 2017) |
| "Naloxone was without epileptogenic properties in animals that had not been pretreated with methadone." | 1.26 | Naloxone-induced electrographic seizures in the primate. ( Beck, EC; Dustmann, RE; Shearer, DE; Snyder, EW, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (51.85) | 18.7374 |
| 1990's | 1 (3.70) | 18.2507 |
| 2000's | 3 (11.11) | 29.6817 |
| 2010's | 8 (29.63) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Prosperi-Porta, G | 1 |
| Oleynick, C | 1 |
| Gholami, M | 1 |
| Saboory, E | 1 |
| Ahmadi, AA | 1 |
| Asouri, M | 1 |
| Nasirikenari, M | 1 |
| Rostamnezhad, M | 1 |
| Kazemi Roodsari, S | 1 |
| Bahramnejad, E | 1 |
| Rahimi, N | 1 |
| Aghaei, I | 1 |
| Dehpour, AR | 1 |
| Adami, C | 1 |
| Spadavecchia, C | 1 |
| Casoni, D | 1 |
| Raina, S | 1 |
| Paydak, H | 1 |
| Al-Lahham, T | 1 |
| Shihabuddin, BS | 1 |
| Talebi, S | 1 |
| Ghobadi, F | 1 |
| Chaudhari, S | 1 |
| Gracia, E | 1 |
| Olatunde, O | 1 |
| Pekler, G | 1 |
| Visco, F | 1 |
| Hassen, GW | 1 |
| Wentlandt, M | 1 |
| Morris, SC | 1 |
| Mitchell, SH | 1 |
| Drynan, EA | 1 |
| Gray, P | 1 |
| Raisis, AL | 1 |
| Tiesmeier, J | 1 |
| Emmerich, M | 1 |
| Johnson, K | 1 |
| Gerada, C | 1 |
| Greenough, A | 1 |
| HAMBURGER, E | 1 |
| VEATCH, RM | 1 |
| ADLER, TK | 1 |
| WAY, EL | 1 |
| Yong, RL | 1 |
| Holmes, DT | 1 |
| Sreenivasan, GM | 1 |
| Frenk, H | 2 |
| Watkins, LR | 2 |
| Mayer, DJ | 2 |
| Miller, J | 1 |
| Snyder, EW | 1 |
| Shearer, DE | 1 |
| Beck, EC | 1 |
| Dustmann, RE | 1 |
| Ziegler, M | 1 |
| Poustka, F | 1 |
| von Loewenich, V | 1 |
| Englert, E | 1 |
| Goddard, J | 1 |
| Wilson, GS | 1 |
| Zelson, C | 2 |
| Davis, MM | 1 |
| Shanks, B | 1 |
| Witkin, JM | 1 |
| Johnson, RE | 1 |
| Jaffe, JH | 1 |
| Goldberg, SR | 1 |
| Grayson, NA | 1 |
| Rice, KC | 1 |
| Katz, JL | 1 |
| Saxon, AJ | 1 |
| Whittaker, S | 1 |
| Hawker, CS | 1 |
| Thornton, WE | 1 |
| Thornton, BP | 1 |
| Lee, SJ | 1 |
| Casalino, M | 1 |
| Granat, FR | 1 |
| Saelens, JK | 1 |
| Zaks, AM | 1 |
| Bruner, A | 1 |
| Fink, M | 1 |
| Freedman, AM | 1 |
| Huidobro, F | 1 |
2 reviews available for methadone and Seizures
| Article | Year |
|---|---|
Treatment of neonatal abstinence syndrome.
Topics: Clinical Trials as Topic; Drug Therapy, Combination; Heroin; Humans; Infant, Newborn; Methadone; Mor | 2003 |
Narcotic poisoning: a review of the literature.
Topics: Chemical and Drug Induced Liver Injury; Drug Contamination; Endocarditis; Heroin Dependence; Humans; | 1974 |
1 trial available for methadone and Seizures
| Article | Year |
|---|---|
Intravenous diacetylmorphine (heroin) in studies of opiate dependence.
Topics: Bridged-Ring Compounds; Clinical Trials as Topic; Cyclazocine; Electroencephalography; Frontal Lobe; | 1969 |
24 other studies available for methadone and Seizures
| Article | Year |
|---|---|
Diffuse Deep T-Wave Inversions Following a Generalized Seizure.
Topics: Adult; Delayed Diagnosis; Diagnosis, Differential; Electrocardiography; Female; Humans; Methadone; P | 2019 |
Long-time effects of prenatal morphine, tramadol, methadone, and buprenorphine exposure on seizure and anxiety in immature rats.
Topics: Animals; Animals, Newborn; Anxiety; Behavior, Animal; Buprenorphine; Female; Locomotion; Male; Maze | 2020 |
Methadone's effects on pentylenetetrazole-induced seizure threshold in mice: NMDA/opioid receptors and nitric oxide signaling.
Topics: Animals; Anticonvulsants; Dizocilpine Maleate; Guanidines; Indazoles; Ketamine; Male; Methadone; Mic | 2019 |
Seizure activity occurring in two dogs after S-ketamine-induction.
Topics: Acepromazine; Analgesics, Opioid; Anesthesia, General; Anesthetics, Dissociative; Animals; Anticonvu | 2013 |
Methadone induced Torsades de Pointes mimicking seizures in clinical presentation.
Topics: Adult; Female; Humans; Methadone; Opioid-Related Disorders; Seizures; Torsades de Pointes | 2014 |
When a seizure is not a real seizure!
Topics: Diagnosis, Differential; Electrocardiography; Female; Humans; Male; Methadone; Middle Aged; Opiate S | 2016 |
Ventricular tachycardia and prolonged QT interval presenting as seizure-like activity.
Topics: Adult; Alcoholism; Anti-Arrhythmia Agents; Anticonvulsants; Diuretics; Electrocardiography; Emergenc | 2017 |
Incidence of seizures associated with the use of acepromazine in dogs undergoing myelography.
Topics: Acepromazine; Analgesics, Opioid; Animals; Dog Diseases; Dogs; Dopamine Antagonists; Female; Male; M | 2012 |
Prehospital transient airway management using the I-gel with sustained spontaneous breathing in different emergency situations.
Topics: Administration, Intranasal; Adult; Aged; Airway Management; Alcoholic Intoxication; Analgesics, Opio | 2013 |
BARBITURATE USE IN NARCOTIC ADDICTS.
Topics: Barbiturates; Codeine; Drug Tolerance; Ethchlorvynol; Glutethimide; Heroin; Hydromorphone; Hypnotics | 1964 |
THE IMPORTANCE OF STERIC CONFIGUA. ION IN CERTAIN MORPHINNE-MIMETIC ACTIONS OF SYNTHETIC ANALGETICS.
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Apnea; Chemical Phenomena; Chemistry; Methadone; | 1964 |
Aluminum toxicity due to intravenous injection of boiled methadone.
Topics: Adult; Aluminum; Ataxia; Chelation Therapy; Deferoxamine; Dysarthria; Humans; Male; Methadone; Poiso | 2006 |
Differential behavioral effects induced by intrathecal microinjection of opiates: comparison of convulsive and cataleptic effects produced by morphine, methadone, and D-Ala2-methionine-enkephalinamide.
Topics: Animals; Arousal; Behavior, Animal; Cerebral Cortex; Dose-Response Relationship, Drug; Electroenceph | 1984 |
Nonspecific convulsions are induced by morphine but not D-Ala2-methionine-enkephalinamide at cortical sites.
Topics: Animals; Cerebral Cortex; Drug Tolerance; Electroencephalography; Enkephalin, Methionine; Evoked Pot | 1984 |
Naloxone-induced electrographic seizures in the primate.
Topics: Animals; Blood Pressure; Body Temperature; Drug Interactions; Electrocardiography; Electroencephalog | 1980 |
[Postpartum risk factors in the development of children born to opiate-addicted mothers; comparison between mothers with and without methadone substitution].
Topics: Adult; Birth Weight; Case-Control Studies; Child Advocacy; Child Development; Female; Germany; Gesta | 2000 |
Management of neonatal drug withdrawal.
Topics: Diazepam; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Seizures | 1978 |
Acute management of neonatal addiction.
Topics: Antidiarrheals; Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant | 1975 |
Neurological aspects of perinatal narcotic addiction and methadone treatment.
Topics: Auditory Perception; Autonomic Nervous System; Birth Weight; Central Nervous System Diseases; Child | 1975 |
The partial opioid agonist, buprenorphine, protects against lethal effects of cocaine.
Topics: Animals; Brain; Buprenorphine; Cocaine; Dose-Response Relationship, Drug; Methadone; Mice; Mice, Inb | 1991 |
Valproic acid, unlike other anticonvulsants, has no effect on methadone metabolism: two cases.
Topics: Adult; Drug Therapy, Combination; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Phenytoin | 1989 |
Neonatal narcotic addiction. Comparative effects of maternal intake of heroin and methadone.
Topics: Adult; Apgar Score; Birth Weight; Chlorpromazine; Female; Gestational Age; Heroin Dependence; Humans | 1973 |
Effect of stimulus intensity on the potency of some analgetic agents.
Topics: Analgesics; Animals; Codeine; Dextropropoxyphene; Dose-Response Relationship, Drug; Drug Interaction | 1973 |
Action of picric acid on the effects of some drugs acting on the central nervous system, with special reference to opioids.
Topics: Amphetamine; Analgesia; Analgesics; Animals; Benzimidazoles; Drug Synergism; Female; Male; Meperidin | 1971 |