Page last updated: 2024-10-30

methadone and Seizures

methadone has been researched along with Seizures in 27 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"To investigate the frequency of seizures associated with acepromazine administration when used as a premedicant with methadone for dogs undergoing myelography."7.78Incidence of seizures associated with the use of acepromazine in dogs undergoing myelography. ( Drynan, EA; Gray, P; Raisis, AL, 2012)
"Naloxone was without epileptogenic properties in animals that had not been pretreated with methadone."5.26Naloxone-induced electrographic seizures in the primate. ( Beck, EC; Dustmann, RE; Shearer, DE; Snyder, EW, 1980)
"We report here 2 cases of methadone induced Torsades de Pointes with a clinical presentation mimicking convulsive seizures in a substance abuser."3.83When a seizure is not a real seizure! ( Chaudhari, S; Ghobadi, F; Gracia, E; Hassen, GW; Olatunde, O; Pekler, G; Talebi, S; Visco, F, 2016)
"To investigate the frequency of seizures associated with acepromazine administration when used as a premedicant with methadone for dogs undergoing myelography."3.78Incidence of seizures associated with the use of acepromazine in dogs undergoing myelography. ( Drynan, EA; Gray, P; Raisis, AL, 2012)
"Cortical application of morphine (25, 100 and 400 micrograms) induced cortical spikes in a dose-related fashion and, at 400 micrograms, behavioral and electrographic seizures."3.67Nonspecific convulsions are induced by morphine but not D-Ala2-methionine-enkephalinamide at cortical sites. ( Frenk, H; Mayer, DJ; Miller, J; Watkins, LR, 1984)
"BACKGROUND Stress cardiomyopathy (SCM) is a transient dysfunction of the left ventricle due to physical or emotional triggers that produces a range of electrocardiogram (ECG) changes."1.51Diffuse Deep T-Wave Inversions Following a Generalized Seizure. ( Oleynick, C; Prosperi-Porta, G, 2019)
"Methadone is a synthetic opioid used to treat opiate withdrawal and addiction."1.51Methadone's effects on pentylenetetrazole-induced seizure threshold in mice: NMDA/opioid receptors and nitric oxide signaling. ( Aghaei, I; Bahramnejad, E; Dehpour, AR; Kazemi Roodsari, S; Rahimi, N, 2019)
"We present a case of seizure activity in a woman in whom EKG led to a diagnosis of intermittent monomorphic and polymorphic ventricular tachycardia (torsades de pointes), highlighting the need for careful consideration of alternative causes of seizures, even in patients with known epilepsy."1.46Ventricular tachycardia and prolonged QT interval presenting as seizure-like activity. ( Mitchell, SH; Morris, SC; Wentlandt, M, 2017)
"Naloxone was without epileptogenic properties in animals that had not been pretreated with methadone."1.26Naloxone-induced electrographic seizures in the primate. ( Beck, EC; Dustmann, RE; Shearer, DE; Snyder, EW, 1980)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-199014 (51.85)18.7374
1990's1 (3.70)18.2507
2000's3 (11.11)29.6817
2010's8 (29.63)24.3611
2020's1 (3.70)2.80

Authors

AuthorsStudies
Prosperi-Porta, G1
Oleynick, C1
Gholami, M1
Saboory, E1
Ahmadi, AA1
Asouri, M1
Nasirikenari, M1
Rostamnezhad, M1
Kazemi Roodsari, S1
Bahramnejad, E1
Rahimi, N1
Aghaei, I1
Dehpour, AR1
Adami, C1
Spadavecchia, C1
Casoni, D1
Raina, S1
Paydak, H1
Al-Lahham, T1
Shihabuddin, BS1
Talebi, S1
Ghobadi, F1
Chaudhari, S1
Gracia, E1
Olatunde, O1
Pekler, G1
Visco, F1
Hassen, GW1
Wentlandt, M1
Morris, SC1
Mitchell, SH1
Drynan, EA1
Gray, P1
Raisis, AL1
Tiesmeier, J1
Emmerich, M1
Johnson, K1
Gerada, C1
Greenough, A1
HAMBURGER, E1
VEATCH, RM1
ADLER, TK1
WAY, EL1
Yong, RL1
Holmes, DT1
Sreenivasan, GM1
Frenk, H2
Watkins, LR2
Mayer, DJ2
Miller, J1
Snyder, EW1
Shearer, DE1
Beck, EC1
Dustmann, RE1
Ziegler, M1
Poustka, F1
von Loewenich, V1
Englert, E1
Goddard, J1
Wilson, GS1
Zelson, C2
Davis, MM1
Shanks, B1
Witkin, JM1
Johnson, RE1
Jaffe, JH1
Goldberg, SR1
Grayson, NA1
Rice, KC1
Katz, JL1
Saxon, AJ1
Whittaker, S1
Hawker, CS1
Thornton, WE1
Thornton, BP1
Lee, SJ1
Casalino, M1
Granat, FR1
Saelens, JK1
Zaks, AM1
Bruner, A1
Fink, M1
Freedman, AM1
Huidobro, F1

Reviews

2 reviews available for methadone and Seizures

ArticleYear
Treatment of neonatal abstinence syndrome.
    Archives of disease in childhood. Fetal and neonatal edition, 2003, Volume: 88, Issue:1

    Topics: Clinical Trials as Topic; Drug Therapy, Combination; Heroin; Humans; Infant, Newborn; Methadone; Mor

2003
Narcotic poisoning: a review of the literature.
    The American journal of psychiatry, 1974, Volume: 131, Issue:8

    Topics: Chemical and Drug Induced Liver Injury; Drug Contamination; Endocarditis; Heroin Dependence; Humans;

1974

Trials

1 trial available for methadone and Seizures

ArticleYear
Intravenous diacetylmorphine (heroin) in studies of opiate dependence.
    Diseases of the nervous system, 1969, Volume: 30, Issue:2

    Topics: Bridged-Ring Compounds; Clinical Trials as Topic; Cyclazocine; Electroencephalography; Frontal Lobe;

1969

Other Studies

24 other studies available for methadone and Seizures

ArticleYear
Diffuse Deep T-Wave Inversions Following a Generalized Seizure.
    The American journal of case reports, 2019, Oct-26, Volume: 20

    Topics: Adult; Delayed Diagnosis; Diagnosis, Differential; Electrocardiography; Female; Humans; Methadone; P

2019
Long-time effects of prenatal morphine, tramadol, methadone, and buprenorphine exposure on seizure and anxiety in immature rats.
    The International journal of neuroscience, 2020, Volume: 130, Issue:9

    Topics: Animals; Animals, Newborn; Anxiety; Behavior, Animal; Buprenorphine; Female; Locomotion; Male; Maze

2020
Methadone's effects on pentylenetetrazole-induced seizure threshold in mice: NMDA/opioid receptors and nitric oxide signaling.
    Annals of the New York Academy of Sciences, 2019, Volume: 1449, Issue:1

    Topics: Animals; Anticonvulsants; Dizocilpine Maleate; Guanidines; Indazoles; Ketamine; Male; Methadone; Mic

2019
Seizure activity occurring in two dogs after S-ketamine-induction.
    Schweizer Archiv fur Tierheilkunde, 2013, Volume: 155, Issue:10

    Topics: Acepromazine; Analgesics, Opioid; Anesthesia, General; Anesthetics, Dissociative; Animals; Anticonvu

2013
Methadone induced Torsades de Pointes mimicking seizures in clinical presentation.
    The American journal of drug and alcohol abuse, 2014, Volume: 40, Issue:6

    Topics: Adult; Female; Humans; Methadone; Opioid-Related Disorders; Seizures; Torsades de Pointes

2014
When a seizure is not a real seizure!
    The American journal of emergency medicine, 2016, Volume: 34, Issue:4

    Topics: Diagnosis, Differential; Electrocardiography; Female; Humans; Male; Methadone; Middle Aged; Opiate S

2016
Ventricular tachycardia and prolonged QT interval presenting as seizure-like activity.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:5

    Topics: Adult; Alcoholism; Anti-Arrhythmia Agents; Anticonvulsants; Diuretics; Electrocardiography; Emergenc

2017
Incidence of seizures associated with the use of acepromazine in dogs undergoing myelography.
    Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001), 2012, Volume: 22, Issue:2

    Topics: Acepromazine; Analgesics, Opioid; Animals; Dog Diseases; Dogs; Dopamine Antagonists; Female; Male; M

2012
Prehospital transient airway management using the I-gel with sustained spontaneous breathing in different emergency situations.
    Minerva anestesiologica, 2013, Volume: 79, Issue:2

    Topics: Administration, Intranasal; Adult; Aged; Airway Management; Alcoholic Intoxication; Analgesics, Opio

2013
BARBITURATE USE IN NARCOTIC ADDICTS.
    JAMA, 1964, Aug-03, Volume: 189

    Topics: Barbiturates; Codeine; Drug Tolerance; Ethchlorvynol; Glutethimide; Heroin; Hydromorphone; Hypnotics

1964
THE IMPORTANCE OF STERIC CONFIGUA. ION IN CERTAIN MORPHINNE-MIMETIC ACTIONS OF SYNTHETIC ANALGETICS.
    The Journal of pharmacology and experimental therapeutics, 1964, Volume: 145

    Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Apnea; Chemical Phenomena; Chemistry; Methadone;

1964
Aluminum toxicity due to intravenous injection of boiled methadone.
    The New England journal of medicine, 2006, Mar-16, Volume: 354, Issue:11

    Topics: Adult; Aluminum; Ataxia; Chelation Therapy; Deferoxamine; Dysarthria; Humans; Male; Methadone; Poiso

2006
Differential behavioral effects induced by intrathecal microinjection of opiates: comparison of convulsive and cataleptic effects produced by morphine, methadone, and D-Ala2-methionine-enkephalinamide.
    Brain research, 1984, May-07, Volume: 299, Issue:1

    Topics: Animals; Arousal; Behavior, Animal; Cerebral Cortex; Dose-Response Relationship, Drug; Electroenceph

1984
Nonspecific convulsions are induced by morphine but not D-Ala2-methionine-enkephalinamide at cortical sites.
    Brain research, 1984, May-07, Volume: 299, Issue:1

    Topics: Animals; Cerebral Cortex; Drug Tolerance; Electroencephalography; Enkephalin, Methionine; Evoked Pot

1984
Naloxone-induced electrographic seizures in the primate.
    Psychopharmacology, 1980, Volume: 67, Issue:3

    Topics: Animals; Blood Pressure; Body Temperature; Drug Interactions; Electrocardiography; Electroencephalog

1980
[Postpartum risk factors in the development of children born to opiate-addicted mothers; comparison between mothers with and without methadone substitution].
    Der Nervenarzt, 2000, Volume: 71, Issue:9

    Topics: Adult; Birth Weight; Case-Control Studies; Child Advocacy; Child Development; Female; Germany; Gesta

2000
Management of neonatal drug withdrawal.
    The Journal of pediatrics, 1978, Volume: 92, Issue:5

    Topics: Diazepam; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Seizures

1978
Acute management of neonatal addiction.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Antidiarrheals; Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant

1975
Neurological aspects of perinatal narcotic addiction and methadone treatment.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Auditory Perception; Autonomic Nervous System; Birth Weight; Central Nervous System Diseases; Child

1975
The partial opioid agonist, buprenorphine, protects against lethal effects of cocaine.
    Drug and alcohol dependence, 1991, Volume: 27, Issue:2

    Topics: Animals; Brain; Buprenorphine; Cocaine; Dose-Response Relationship, Drug; Methadone; Mice; Mice, Inb

1991
Valproic acid, unlike other anticonvulsants, has no effect on methadone metabolism: two cases.
    The Journal of clinical psychiatry, 1989, Volume: 50, Issue:6

    Topics: Adult; Drug Therapy, Combination; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Phenytoin

1989
Neonatal narcotic addiction. Comparative effects of maternal intake of heroin and methadone.
    The New England journal of medicine, 1973, Dec-06, Volume: 289, Issue:23

    Topics: Adult; Apgar Score; Birth Weight; Chlorpromazine; Female; Gestational Age; Heroin Dependence; Humans

1973
Effect of stimulus intensity on the potency of some analgetic agents.
    Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 205, Issue:1

    Topics: Analgesics; Animals; Codeine; Dextropropoxyphene; Dose-Response Relationship, Drug; Drug Interaction

1973
Action of picric acid on the effects of some drugs acting on the central nervous system, with special reference to opioids.
    Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 192, Issue:2

    Topics: Amphetamine; Analgesia; Analgesics; Animals; Benzimidazoles; Drug Synergism; Female; Male; Meperidin

1971