Page last updated: 2024-10-30

methadone and Scoliosis

methadone has been researched along with Scoliosis in 6 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Scoliosis: An appreciable lateral deviation in the normally straight vertical line of the spine. (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"Using a prospective, randomized, blinded design, adolescents presenting for posterior spinal fusion to treat idiopathic scoliosis were assigned to receive desflurane with remifentanil alone (REMI), remifentanil + methadone (MET) (0."9.27Analgesic effects of methadone and magnesium following posterior spinal fusion for idiopathic scoliosis in adolescents: a randomized controlled trial. ( Barry, N; Beebe, AC; Bhalla, T; Gill, L; Klamar, J; Martin, DP; Rice, J; Samora, WP; Thung, A; Tobias, JD; Tumin, D; Veneziano, G, 2018)
"Intraoperative methadone has been shown to decrease opioid medication requirement following posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS)."8.02In-hospital opioid usage following posterior spinal fusion for adolescent idiopathic scoliosis: Does methadone offer an advantage when used with an ERAS pathway? ( Chhatbar, P; Devito, DP; Fabregas, J; Fletcher, ND; Gidwani, S; Murphy, JS; Schmitz, ML; Shaw, KA, 2021)
"Adolescents undergoing posterior spinal fusion (PSF) for idiopathic scoliosis or pectus excavatum (PE) repair received methadone intraoperatively (0."5.41A Novel Perioperative Multidose Methadone-Based Multimodal Analgesic Strategy in Children Achieved Safe and Low Analgesic Blood Methadone Levels Enabling Opioid-Sparing Sustained Analgesia With Minimal Adverse Effects. ( Aruldhas, BW; Fitzgerald, RE; Overholser, BR; Packiasabapathy, S; Quinney, SK; Renschler, JS; Sadhasivam, S; Zang, Y; Zhang, P, 2021)
"Using a prospective, randomized, blinded design, adolescents presenting for posterior spinal fusion to treat idiopathic scoliosis were assigned to receive desflurane with remifentanil alone (REMI), remifentanil + methadone (MET) (0."5.27Analgesic effects of methadone and magnesium following posterior spinal fusion for idiopathic scoliosis in adolescents: a randomized controlled trial. ( Barry, N; Beebe, AC; Bhalla, T; Gill, L; Klamar, J; Martin, DP; Rice, J; Samora, WP; Thung, A; Tobias, JD; Tumin, D; Veneziano, G, 2018)
"The final methadone study cohort was 31 adolescents (14 ± 2 yr, range 10-18) undergoing major spine surgery for a diagnosis of scoliosis."3.77Perioperative pharmacokinetics of methadone in adolescents. ( Blood, J; Kharasch, ED; Kim, T; London, A; Sharma, A; Tallchief, D, 2011)
"The optimal methadone dosing regimen for children undergoing spinal surgery is uncertain because of sparse pediatric pharmacokinetic data and a paucity of analgesic effect data."1.39The pharmacokinetics of methadone in adolescents undergoing posterior spinal fusion. ( Abel, MF; Anderson, BJ; Balireddy, R; Colquhoun, DA; Durieux, ME; Langman, LJ; Stemland, CJ; Thammishetti, S; Witte, J, 2013)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (50.00)24.3611
2020's3 (50.00)2.80

Authors

AuthorsStudies
Mok, V1
Sweetman, S1
Hernandez, B1
Casias, T1
Hylton, J1
Krause, BM1
Noonan, KJ1
Walker, BJ1
Sadhasivam, S1
Aruldhas, BW1
Packiasabapathy, S1
Overholser, BR1
Zhang, P1
Zang, Y1
Renschler, JS1
Fitzgerald, RE1
Quinney, SK1
Shaw, KA1
Fletcher, ND1
Devito, DP1
Schmitz, ML1
Fabregas, J1
Gidwani, S1
Chhatbar, P1
Murphy, JS1
Martin, DP1
Samora, WP1
Beebe, AC1
Klamar, J1
Gill, L1
Bhalla, T1
Veneziano, G1
Thung, A1
Tumin, D1
Barry, N1
Rice, J1
Tobias, JD1
Sharma, A1
Tallchief, D1
Blood, J1
Kim, T1
London, A1
Kharasch, ED1
Stemland, CJ1
Witte, J1
Colquhoun, DA1
Durieux, ME1
Langman, LJ1
Balireddy, R1
Thammishetti, S1
Abel, MF1
Anderson, BJ1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pharmacogenetics and Pharmacokinetics of Oxycodone to Personalize Postoperative Pain Management Following Major Inpatient Surgery in Children[NCT03495388]500 participants (Anticipated)Observational2018-04-01Active, not recruiting
Analgesia Following Posterior Spinal Fusion: Methadone vs Magnesium[NCT01795495]Phase 263 participants (Actual)Interventional2013-09-30Completed
Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients[NCT02558010]Phase 358 participants (Actual)Interventional2016-02-01Completed
Single-dose Intraoperative Methadone for Early Ambulation and Sustained Pain Control in Spinal Fusion Surgery Patients[NCT02989597]Phase 410 participants (Actual)Interventional2017-07-29Terminated (stopped due to Due to personnel loss and logistical issues the study was unable to be completed as planned.)
A Randomized Blinded Prospective Trial Comparing Single Intraoperative Dose of Methadone Versus Placebo in Pediatric Patients Undergoing Spine Surgery.[NCT02206685]Phase 474 participants (Actual)Interventional2014-05-31Completed
The Effect of Methadone vs. Fentanyl Administration on Postoperative Pain Control in Pediatric Patients Undergoing Cardiac Surgery: A Randomized, Double-Blinded Controlled Trial[NCT02747875]26 participants (Actual)Interventional2016-09-30Terminated (stopped due to Drug Shortage)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Intra- and Post-operative Pain Relief

To prospectively compare the effects of intra-operative methadone and magnesium on postoperative opioid requirements. Total amount of hydromorphone administered in OR, recovery room (PACU), and on the inpatient ward 24 hours post-operatively. (NCT01795495)
Timeframe: Intra-operative and 24 hours post-operatively

Interventionmg/kg (Mean)
Remifentanil0.34
Remifentanil Plus Methadone0.26
Remifentanil Plus Magnesium0.38

Post-operative Pain Scores

VAS pain score - 0 being no pain and 10 being worst pain. (NCT01795495)
Timeframe: Post-operatively to 24 hours

Interventionunits on a scale (Mean)
Remifentanil4.6
Remifentanil Plus Methadone5.1
Remifentanil Plus Magnesium5.1

Post-operative Opioid Consumption (mg/kg)

Total amount of opioids consumed during the first 72 hours after surgery. (NCT02558010)
Timeframe: 72 hours

Interventionmg/kg (Median)
Methadone Group0.267
Control Group0.340

Opioid Usage

Subjects were given access to Patient-Controlled Intravenous Opioid Administration (PCA) to manage their post-operative pain. The doses of morphine were calculated at at PACU, 24 hours, 48 hours and 72 hours respectively. (NCT02206685)
Timeframe: Admission to PACU to 72 hours post-operative

,
Interventionmg/kg (Median)
PACU24 Hours48 Hours72 Hours
Control Group0.470.550.550.04
Treatment Group0.410.580.580.10

Pain Scores

The FLACC scale or Face, Legs, Activity, Cry, Consolability scale is a measurement used to assess pain for children between the ages of 2 months and 7 years or individuals that are unable to communicate their pain. The scale is scored in a range of 0-10 with 0 representing no pain. The scale has five criteria, which are each assigned a score of 0, 1 or 2. The data reported here represents the mean difference in FLACC score by treatment group at PACU, 24 hours, 48 hours and 72 hours, respectively. (NCT02206685)
Timeframe: Admission to PACU to 72 hours post-operative

,
Interventionunits on a scale (Mean)
PACU24 Hours48 Hours72 Hours
Control Group0.650.420.360.29
Treatment Group0.530.140.240.16

Total Opioid Dose, in Morphine Equivalents, in the First 24 Hours After Pediatric Cardiac Bypass Surgery.

The distribution of the total opioid dose in the first 24 hours will be evaluated by randomization group (methadone vs. fentanyl) and differences between groups will be tested. It is hypothesized that compared to fentanyl, methadone administered intraoperative will result in a significantly lower total opioid dose (morphine or oxycodone) during the first 24 hour postoperative period. Assuming no difference between the two treatment strategies in the population, a total sample size of 52 in each group will provide 80% power to detect an effect size of 0.1. Significance will be measured as a 30% reduction in postoperative pain requirement. (NCT02747875)
Timeframe: 24 hours

Interventionmg postop morphine equivelant 24hr (Mean)
Control - Fentanyl0.55
Treatment - Methadone0.48

Opioid-related Adverse Events Including: Respiratory Failure, Cardiovascular Instability, and Postoperative Nausea and Vomiting

Opioid-related adverse events will be monitored closely and a secondary analysis will compare the incidence of side effects between the two groups during the first 24-hour postoperative period. The Pearson's contingency chi-square test will be used to evaluate any differences between the randomization groups in opioid-related adverse events during the first 24-hour postoperative period. (NCT02747875)
Timeframe: 24 hours

,
Interventionevents (Mean)
Ondansetron DosesEmesis EpisodesHypoventilation EpisodesArrhythmias
Control - Fentanyl3.812.7200
Treatment - Methadone3.432.0800

Trials

2 trials available for methadone and Scoliosis

ArticleYear
A Novel Perioperative Multidose Methadone-Based Multimodal Analgesic Strategy in Children Achieved Safe and Low Analgesic Blood Methadone Levels Enabling Opioid-Sparing Sustained Analgesia With Minimal Adverse Effects.
    Anesthesia and analgesia, 2021, 08-01, Volume: 133, Issue:2

    Topics: Adolescent; Age Factors; Analgesics, Opioid; Child; Drug Administration Schedule; Drug Monitoring; F

2021
Analgesic effects of methadone and magnesium following posterior spinal fusion for idiopathic scoliosis in adolescents: a randomized controlled trial.
    Journal of anesthesia, 2018, Volume: 32, Issue:5

    Topics: Adolescent; Analgesics, Opioid; Desflurane; Female; Humans; Hyperalgesia; Magnesium; Male; Methadone

2018

Other Studies

4 other studies available for methadone and Scoliosis

ArticleYear
Scheduled methadone reduces overall opioid requirements after pediatric posterior spinal fusion: A single center retrospective case series.
    Paediatric anaesthesia, 2022, Volume: 32, Issue:10

    Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics, Opioid; Child; Humans; Hydromorphone; Methado

2022
In-hospital opioid usage following posterior spinal fusion for adolescent idiopathic scoliosis: Does methadone offer an advantage when used with an ERAS pathway?
    Spine deformity, 2021, Volume: 9, Issue:4

    Topics: Adolescent; Analgesics, Opioid; Child; Enhanced Recovery After Surgery; Hospitals; Humans; Methadone

2021
Perioperative pharmacokinetics of methadone in adolescents.
    Anesthesiology, 2011, Volume: 115, Issue:6

    Topics: Adolescent; Analgesics, Opioid; Analysis of Variance; Anesthesia, General; Child; Child, Preschool;

2011
Perioperative pharmacokinetics of methadone in adolescents.
    Anesthesiology, 2011, Volume: 115, Issue:6

    Topics: Adolescent; Analgesics, Opioid; Analysis of Variance; Anesthesia, General; Child; Child, Preschool;

2011
Perioperative pharmacokinetics of methadone in adolescents.
    Anesthesiology, 2011, Volume: 115, Issue:6

    Topics: Adolescent; Analgesics, Opioid; Analysis of Variance; Anesthesia, General; Child; Child, Preschool;

2011
Perioperative pharmacokinetics of methadone in adolescents.
    Anesthesiology, 2011, Volume: 115, Issue:6

    Topics: Adolescent; Analgesics, Opioid; Analysis of Variance; Anesthesia, General; Child; Child, Preschool;

2011
Perioperative pharmacokinetics of methadone in adolescents.
    Anesthesiology, 2011, Volume: 115, Issue:6

    Topics: Adolescent; Analgesics, Opioid; Analysis of Variance; Anesthesia, General; Child; Child, Preschool;

2011
Perioperative pharmacokinetics of methadone in adolescents.
    Anesthesiology, 2011, Volume: 115, Issue:6

    Topics: Adolescent; Analgesics, Opioid; Analysis of Variance; Anesthesia, General; Child; Child, Preschool;

2011
Perioperative pharmacokinetics of methadone in adolescents.
    Anesthesiology, 2011, Volume: 115, Issue:6

    Topics: Adolescent; Analgesics, Opioid; Analysis of Variance; Anesthesia, General; Child; Child, Preschool;

2011
Perioperative pharmacokinetics of methadone in adolescents.
    Anesthesiology, 2011, Volume: 115, Issue:6

    Topics: Adolescent; Analgesics, Opioid; Analysis of Variance; Anesthesia, General; Child; Child, Preschool;

2011
Perioperative pharmacokinetics of methadone in adolescents.
    Anesthesiology, 2011, Volume: 115, Issue:6

    Topics: Adolescent; Analgesics, Opioid; Analysis of Variance; Anesthesia, General; Child; Child, Preschool;

2011
Perioperative pharmacokinetics of methadone in adolescents.
    Anesthesiology, 2011, Volume: 115, Issue:6

    Topics: Adolescent; Analgesics, Opioid; Analysis of Variance; Anesthesia, General; Child; Child, Preschool;

2011
Perioperative pharmacokinetics of methadone in adolescents.
    Anesthesiology, 2011, Volume: 115, Issue:6

    Topics: Adolescent; Analgesics, Opioid; Analysis of Variance; Anesthesia, General; Child; Child, Preschool;

2011
Perioperative pharmacokinetics of methadone in adolescents.
    Anesthesiology, 2011, Volume: 115, Issue:6

    Topics: Adolescent; Analgesics, Opioid; Analysis of Variance; Anesthesia, General; Child; Child, Preschool;

2011
Perioperative pharmacokinetics of methadone in adolescents.
    Anesthesiology, 2011, Volume: 115, Issue:6

    Topics: Adolescent; Analgesics, Opioid; Analysis of Variance; Anesthesia, General; Child; Child, Preschool;

2011
Perioperative pharmacokinetics of methadone in adolescents.
    Anesthesiology, 2011, Volume: 115, Issue:6

    Topics: Adolescent; Analgesics, Opioid; Analysis of Variance; Anesthesia, General; Child; Child, Preschool;

2011
Perioperative pharmacokinetics of methadone in adolescents.
    Anesthesiology, 2011, Volume: 115, Issue:6

    Topics: Adolescent; Analgesics, Opioid; Analysis of Variance; Anesthesia, General; Child; Child, Preschool;

2011
Perioperative pharmacokinetics of methadone in adolescents.
    Anesthesiology, 2011, Volume: 115, Issue:6

    Topics: Adolescent; Analgesics, Opioid; Analysis of Variance; Anesthesia, General; Child; Child, Preschool;

2011
The pharmacokinetics of methadone in adolescents undergoing posterior spinal fusion.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:1

    Topics: Adolescent; Adult; Analgesics, Opioid; Child; Female; Follow-Up Studies; Half-Life; Humans; Methadon

2013
The pharmacokinetics of methadone in adolescents undergoing posterior spinal fusion.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:1

    Topics: Adolescent; Adult; Analgesics, Opioid; Child; Female; Follow-Up Studies; Half-Life; Humans; Methadon

2013
The pharmacokinetics of methadone in adolescents undergoing posterior spinal fusion.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:1

    Topics: Adolescent; Adult; Analgesics, Opioid; Child; Female; Follow-Up Studies; Half-Life; Humans; Methadon

2013
The pharmacokinetics of methadone in adolescents undergoing posterior spinal fusion.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:1

    Topics: Adolescent; Adult; Analgesics, Opioid; Child; Female; Follow-Up Studies; Half-Life; Humans; Methadon

2013
The pharmacokinetics of methadone in adolescents undergoing posterior spinal fusion.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:1

    Topics: Adolescent; Adult; Analgesics, Opioid; Child; Female; Follow-Up Studies; Half-Life; Humans; Methadon

2013
The pharmacokinetics of methadone in adolescents undergoing posterior spinal fusion.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:1

    Topics: Adolescent; Adult; Analgesics, Opioid; Child; Female; Follow-Up Studies; Half-Life; Humans; Methadon

2013
The pharmacokinetics of methadone in adolescents undergoing posterior spinal fusion.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:1

    Topics: Adolescent; Adult; Analgesics, Opioid; Child; Female; Follow-Up Studies; Half-Life; Humans; Methadon

2013
The pharmacokinetics of methadone in adolescents undergoing posterior spinal fusion.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:1

    Topics: Adolescent; Adult; Analgesics, Opioid; Child; Female; Follow-Up Studies; Half-Life; Humans; Methadon

2013
The pharmacokinetics of methadone in adolescents undergoing posterior spinal fusion.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:1

    Topics: Adolescent; Adult; Analgesics, Opioid; Child; Female; Follow-Up Studies; Half-Life; Humans; Methadon

2013