Page last updated: 2024-10-30

methadone and Respiratory Insufficiency

methadone has been researched along with Respiratory Insufficiency in 50 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Respiratory Insufficiency: Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)

Research Excerpts

ExcerptRelevanceReference
"Methadone is highly effective in treating opioid dependence, and it is also used as an analgesic for second-line management of chronic pain."8.86Methadone deaths: risk factors in pain and addicted populations. ( Brooks, D; Modesto-Lowe, V; Petry, N, 2010)
"Methadone may cause respiratory depression."5.36Mechanisms of respiratory insufficiency induced by methadone overdose in rats. ( Baud, FJ; Chevillard, L; Declèves, X; Mager, D; Mégarbane, B; Milan, N; Ricordel, I; Risède, P, 2010)
"Methadone is a long-acting mu-opioid and is an effective treatment for heroin addiction."5.33Ventilatory responses to hypoxia and hypercapnia in stable methadone maintenance treatment patients. ( Cunnington, D; Drummer, OH; Kronborg, I; Quinnell, T; Teichtahl, H; Tran, H; Wang, D, 2005)
"Methadone is highly effective in treating opioid dependence, and it is also used as an analgesic for second-line management of chronic pain."4.86Methadone deaths: risk factors in pain and addicted populations. ( Brooks, D; Modesto-Lowe, V; Petry, N, 2010)
"We reports a six-year-old child with autistic disorder and methadone intoxication."3.80Be careful of lies: a six-year-old boy with respiratory distress and decreased level of consciousness. ( Farshadmoghadam, H; Gharib, B; Hosseini, F; Yaghmaie, B, 2014)
"Methadone, the most widely delivered maintenance therapy for heroin addicts, may be responsible for life-threatening poisonings with respiratory depression."3.74Case report: quantification of methadone-induced respiratory depression using toxicokinetic/toxicodynamic relationships. ( Bardin, C; Baud, FJ; Bloch, V; Chast, F; Declèves, X; Mégarbane, B, 2007)
"We report on the preclinical management of a 4-year-old child who was found in a comatose condition with respiratory failure after accidental ingestion of methadone."3.72[Preclinical management of accidental methadone intoxication of a 4-year-old girl. Antagonist or intubation?]. ( Bernhard, M; Gries, A; Hainer, C, 2004)
"Immediate attention must be given to the respiratory system of the heroin abuser; then he should be given naloxone HCl."3.65Treating heroin overdose. ( Calabro, JJ; Neaderthal, RL, 1975)
"Buprenorphine appears to be a safe and effective substitute for naloxone in overdosed opioid-dependent patients."2.94Buprenorphine to reverse respiratory depression from methadone overdose in opioid-dependent patients: a prospective randomized trial. ( Buckley, NA; Hassanian-Moghaddam, H; Zamani, N, 2020)
" We systematically searched for studies of acute toxicity of quetiapine or other antipsychotics combined with morphine or methadone."2.72Quetiapine and other antipsychotics combined with opioids in legal autopsy cases: A random finding or cause of fatal outcome? ( Andersen, CU; Andersen, FD; Simonsen, U, 2021)
"Objective and subjective withdrawal symptoms were measured until urine was free of drugs and patients had no withdrawal symptoms."2.69Opiate detoxification under anesthesia: no apparent benefit but suppression of thyroid hormones and risk of pulmonary and renal failure. ( Hirtl, C; Pfab, R; Zilker, T, 1999)
"Postoperative pain is not adequately managed in greater than 40% of surgical patients and is a high priority for perioperative research."2.66Intraoperative methadone administration and postoperative pain control: a systematic review and meta-analysis. ( D'Souza, RS; Gurrieri, C; Johnson, RL; Warner, N; Wittwer, E, 2020)
"Opioid-induced respiratory depression limits the use of μ-opioid receptor agonists in clinical settings and is the main cause of opioid overdose fatalities."1.91Assessment of the potential of novel and classical opioids to induce respiratory depression in mice. ( Antonijevic, M; Canals, M; Hill, R; Hosking, Y; Javitch, JA; Kruegel, AC; Lane, JR; Lemel, L; Mistry, SN; Sanchez, J, 2023)
" Clinically significant MDIs included withdrawal symptoms, which were found among MMTP patients co-administered with buprenorphine or tramadol; severe QTc prolongation effect, which might be associated with use of haloperidol or droperidol; and additive CNS and respiratory depression, which could result from use of methadone in combination with chlorpromazine or thioridazine."1.38Survey of methadone-drug interactions among patients of methadone maintenance treatment program in Taiwan. ( Lee, HY; Li, JH; Tang, HP; Wu, JS; Wu, LT; Yen, CF, 2012)
"Methadone may cause respiratory depression."1.36Mechanisms of respiratory insufficiency induced by methadone overdose in rats. ( Baud, FJ; Chevillard, L; Declèves, X; Mager, D; Mégarbane, B; Milan, N; Ricordel, I; Risède, P, 2010)
"Opioids are known to induce respiratory depression."1.35Characteristics and comparative severity of respiratory response to toxic doses of fentanyl, methadone, morphine, and buprenorphine in rats. ( Baud, FJ; Chevillard, L; Mégarbane, B; Risède, P, 2009)
"Methadone is an interesting analgesic for multiple reasons."1.35The safety of methadone hydrochloride. ( Swegle, JM; Wensel, DD, 2008)
"While the depth of methadone-induced respiratory depression did not depend on pup age, the control of breathing was different in 3-day-old pups, where inspiratory time increased fourfold; twice that of older pups."1.34Methadone-induced respiratory depression in the neonatal guinea pig. ( Abraham, SL; Nelson, CS; Nettleton, RT; Olsen, GD; Ransom, TA, 2007)
"Methadone is a long-acting mu-opioid and is an effective treatment for heroin addiction."1.33Ventilatory responses to hypoxia and hypercapnia in stable methadone maintenance treatment patients. ( Cunnington, D; Drummer, OH; Kronborg, I; Quinnell, T; Teichtahl, H; Tran, H; Wang, D, 2005)
"However, he developed respiratory depression 2 days after intravenous fluconazole was administrated for refractory oral candidiasis."1.31Methadone and fluconazole: respiratory depression by drug interaction. ( Pereira, J; Tarumi, Y; Watanabe, S, 2002)
" The relationship between drug effect and the systemic bioavailability of methadone, measured as the area under the plasma concentration-time curve (AUC0-180), was also evaluated."1.29The effect of changes in gastric pH induced by omeprazole on the absorption and respiratory depression of methadone. ( Aguirre, C; Calvo, R; de Castro, J; Garrido, MJ; Gómez, E; Rodríguez-Sasiaín, JM, 1996)

Research

Studies (50)

TimeframeStudies, this research(%)All Research%
pre-19907 (14.00)18.7374
1990's5 (10.00)18.2507
2000's15 (30.00)29.6817
2010's13 (26.00)24.3611
2020's10 (20.00)2.80

Authors

AuthorsStudies
Tas, B1
Kalk, NJ1
Lozano-García, M1
Rafferty, GF1
Cho, P1
Kelleher, M1
Moxham, J1
Strang, J1
Jolley, CJ1
Komatsu, R1
Nash, MG1
Wu, J2
Dinges, EM1
Delgado, CM1
Bollag, LA1
Hill, R1
Sanchez, J2
Lemel, L1
Antonijevic, M1
Hosking, Y1
Mistry, SN1
Kruegel, AC1
Javitch, JA1
Lane, JR1
Canals, M1
D'Souza, RS1
Gurrieri, C1
Johnson, RL1
Warner, N1
Wittwer, E1
Zamani, N3
Buckley, NA1
Hassanian-Moghaddam, H3
Halim, AA1
Alsayed, B1
Embarak, S1
Yaseen, T1
Dabbous, S1
Fontaine, O1
Dueluzeau, R1
Raibaud, P1
Chabanet, C1
Popoff, MR1
Badoual, J1
Gabilan, JC1
Andremont, A1
Gómez, L1
Andrés, S1
Alonso, JM1
Rey, J1
López, F1
Jiménez, A1
Yan, Z1
Zhou, L1
Zhao, Y3
Wang, J6
Huang, L2
Hu, K1
Liu, H4
Wang, H3
Guo, Z1
Song, Y1
Huang, H4
Yang, R1
Owen, TW1
Al-Kaysi, RO1
Bardeen, CJ1
Cheng, Q1
Wu, S1
Cheng, T1
Zhou, X1
Wang, B4
Zhang, Q4
Wu, X2
Yao, Y3
Ochiai, T1
Ishiguro, H2
Nakano, R2
Kubota, Y2
Hara, M1
Sunada, K1
Hashimoto, K1
Kajioka, J1
Fujishima, A1
Jiao, J3
Gai, QY3
Wang, W2
Zang, YP2
Niu, LL2
Fu, YJ3
Wang, X4
Yao, LP1
Qin, QP1
Wang, ZY1
Liu, J4
Aleksic Sabo, V1
Knezevic, P1
Borges-Argáez, R1
Chan-Balan, R1
Cetina-Montejo, L1
Ayora-Talavera, G1
Sansores-Peraza, P1
Gómez-Carballo, J1
Cáceres-Farfán, M1
Jang, J1
Akin, D1
Bashir, R1
Yu, Z1
Zhu, J2
Jiang, H1
He, C2
Xiao, Z1
Xu, J2
Sun, Q1
Han, D1
Lei, H1
Zhao, K2
Zhu, L1
Li, X4
Fu, H2
Wilson, BK1
Step, DL1
Maxwell, CL1
Gifford, CA1
Richards, CJ1
Krehbiel, CR1
Warner, JM1
Doerr, AJ1
Erickson, GE1
Guretzky, JA1
Rasby, RJ1
Watson, AK1
Klopfenstein, TJ1
Sun, Y4
Liu, Z3
Pham, TD1
Lee, BK1
Yang, FC1
Wu, KH1
Lin, WP1
Hu, MK1
Lin, L3
Shao, J1
Sun, M1
Xu, G1
Zhang, X6
Xu, N1
Wang, R1
Liu, S1
He, H1
Dong, X2
Yang, M2
Yang, Q1
Duan, S1
Yu, Y2
Han, J2
Zhang, C3
Chen, L2
Yang, X1
Li, W3
Wang, T2
Campbell, DA1
Gao, K1
Zager, RA1
Johnson, ACM1
Guillem, A1
Keyser, J1
Singh, B1
Steubl, D1
Schneider, MP1
Meiselbach, H1
Nadal, J1
Schmid, MC1
Saritas, T1
Krane, V1
Sommerer, C1
Baid-Agrawal, S1
Voelkl, J1
Kotsis, F1
Köttgen, A1
Eckardt, KU1
Scherberich, JE1
Li, H4
Yao, L2
Sun, L3
Zhu, Z1
Naren, N1
Zhang, XX2
Gentile, GL1
Rupert, AS1
Carrasco, LI1
Garcia, EM1
Kumar, NG1
Walsh, SW1
Jefferson, KK1
Guest, RL1
Samé Guerra, D1
Wissler, M1
Grimm, J1
Silhavy, TJ1
Lee, JH2
Yoo, JS1
Kim, Y1
Kim, JS2
Lee, EJ1
Roe, JH1
Delorme, M1
Bouchard, PA1
Simon, M1
Simard, S1
Lellouche, F1
D'Urzo, KA1
Mok, F1
D'Urzo, AD1
Koneru, B1
Lopez, G1
Farooqi, A1
Conkrite, KL1
Nguyen, TH1
Macha, SJ1
Modi, A1
Rokita, JL1
Urias, E1
Hindle, A1
Davidson, H1
Mccoy, K1
Nance, J1
Yazdani, V1
Irwin, MS1
Yang, S1
Wheeler, DA1
Maris, JM1
Diskin, SJ1
Reynolds, CP1
Abhilash, L1
Kalliyil, A1
Sheeba, V1
Hartley, AM2
Meunier, B2
Pinotsis, N1
Maréchal, A2
Xu, JY1
Genko, N1
Haraux, F1
Rich, PR1
Kamalanathan, M1
Doyle, SM1
Xu, C1
Achberger, AM1
Wade, TL1
Schwehr, K1
Santschi, PH1
Sylvan, JB1
Quigg, A1
Leong, W1
Xu, W2
Gao, S1
Zhai, X1
Wang, C2
Gilson, E1
Ye, J1
Lu, Y1
Yan, R1
Zhang, Y6
Hu, Z1
You, Q1
Cai, Q1
Yang, D1
Gu, S1
Dai, H1
Zhao, X1
Gui, C1
Gui, J1
Wu, PK1
Hong, SK1
Starenki, D1
Oshima, K1
Shao, H1
Gestwicki, JE1
Tsai, S1
Park, JI1
Wang, Y7
Zhao, R1
Gu, Z1
Dong, C2
Guo, G1
Li, L4
Barrett, HE1
Meester, EJ1
van Gaalen, K1
van der Heiden, K1
Krenning, BJ1
Beekman, FJ1
de Blois, E1
de Swart, J1
Verhagen, HJ1
Maina, T1
Nock, BA1
Norenberg, JP1
de Jong, M1
Gijsen, FJH1
Bernsen, MR1
Martínez-Milla, J1
Galán-Arriola, C1
Carnero, M1
Cobiella, J1
Pérez-Camargo, D1
Bautista-Hernández, V1
Rigol, M1
Solanes, N1
Villena-Gutierrez, R1
Lobo, M1
Mateo, J1
Vilchez-Tschischke, JP1
Salinas, B1
Cussó, L1
López, GJ1
Fuster, V1
Desco, M1
Sanchez-González, J1
Ibanez, B1
van den Berg, P1
Schweitzer, DH1
van Haard, PMM1
Geusens, PP1
van den Bergh, JP1
Zhu, X1
Huang, X2
Xu, H2
Yang, G2
Lin, Z1
Salem, HF1
Nafady, MM1
Kharshoum, RM1
Abd El-Ghafar, OA1
Farouk, HO1
Domiciano, D1
Nery, FC1
de Carvalho, PA1
Prudente, DO1
de Souza, LB1
Chalfun-Júnior, A1
Paiva, R1
Marchiori, PER1
Lu, M2
An, Z1
Jiang, J2
Li, J7
Du, S1
Zhou, H1
Cui, J1
Wu, W1
Liu, Y7
Song, J1
Lian, Q1
Uddin Ahmad, Z1
Gang, DD1
Konggidinata, MI1
Gallo, AA1
Zappi, ME1
Yang, TWW1
Johari, Y1
Burton, PR1
Earnest, A1
Shaw, K1
Hare, JL1
Brown, WA1
Kim, GA1
Han, S1
Choi, GH1
Choi, J1
Lim, YS1
Gallo, A1
Cancelli, C1
Ceron, E1
Covino, M1
Capoluongo, E1
Pocino, K1
Ianiro, G1
Cammarota, G1
Gasbarrini, A1
Montalto, M1
Somasundar, Y1
Lu, IC1
Mills, MR1
Qian, LY1
Olivares, X1
Ryabov, AD1
Collins, TJ1
Zhao, L1
Doddipatla, S1
Thomas, AM1
Nikolayev, AA1
Galimova, GR1
Azyazov, VN1
Mebel, AM1
Kaiser, RI1
Guo, S1
Yang, P1
Yu, X2
Wu, Y2
Zhang, H1
Yu, B2
Han, B1
George, MW1
Moor, MB1
Bonny, O1
Langenberg, E1
Paik, H1
Smith, EH1
Nair, HP1
Hanke, I1
Ganschow, S1
Catalan, G1
Domingo, N1
Schlom, DG1
Assefa, MK1
Wu, G2
Hayton, TW1
Becker, B1
Enikeev, D1
Netsch, C1
Gross, AJ1
Laukhtina, E1
Glybochko, P1
Rapoport, L1
Herrmann, TRW1
Taratkin, M1
Dai, W1
Shi, J2
Carreno, J1
Kloner, RA1
Pickersgill, NA1
Vetter, JM1
Kim, EH1
Cope, SJ1
Du, K1
Venkatesh, R1
Giardina, JD1
Saad, NES1
Bhayani, SB1
Figenshau, RS1
Eriksson, J1
Landfeldt, E1
Ireland, S1
Jackson, C1
Wyatt, E1
Gaudig, M1
Stancill, JS1
Happ, JT1
Broniowska, KA1
Hogg, N1
Corbett, JA1
Tang, LF1
Bi, YL1
Fan, Y2
Sun, YB1
Wang, AL1
Xiao, BH1
Wang, LF1
Qiu, SW1
Guo, SW1
Wáng, YXJ1
Sun, J2
Chu, S1
Pan, Q1
Li, D2
Zheng, S2
Ma, L1
Wang, L3
Hu, T1
Wang, F1
Han, Z1
Yin, Z1
Ge, X1
Xie, K1
Lei, P1
Dias-Santagata, D1
Lennerz, JK1
Sadow, PM1
Frazier, RP1
Govinda Raju, S1
Henry, D1
Chung, T1
Kherani, J1
Rothenberg, SM1
Wirth, LJ1
Marti, CN1
Choi, NG1
Bae, SJ1
Ni, L1
Luo, X1
Dai, T1
Yang, Y3
Lee, R1
Fleischer, AS1
Wemhoff, AP1
Ford, CR1
Kleppinger, EL1
Helms, K1
Bush, AA1
Luna-Abanto, J1
García Ruiz, L1
Laura Martinez, J1
Álvarez Larraondo, M1
Villoslada Terrones, V1
Dukic, L1
Maric, N1
Simundic, AM1
Chogtu, B1
Ommurugan, B1
Thomson, SR1
Kalthur, SG1
Benidir, M1
El Massoudi, S1
El Ghadraoui, L1
Lazraq, A1
Benjelloun, M1
Errachidi, F1
Cassar, M1
Law, AD1
Chow, ES1
Giebultowicz, JM1
Kretzschmar, D1
Salonurmi, T1
Nabil, H1
Ronkainen, J1
Hyötyläinen, T1
Hautajärvi, H1
Savolainen, MJ1
Tolonen, A1
Orešič, M1
Känsäkoski, P1
Rysä, J1
Hakkola, J1
Hukkanen, J1
Zhu, N1
Li, Y4
Du, Q1
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Cao, X1
Li, CX1
Zhao, S1
Luo, XM1
Feng, JX1
Gonzalez-Cotto, M1
Guo, L1
Karwan, M1
Sen, SK1
Barb, J1
Collado, CJ1
Elloumi, F1
Palmieri, EM1
Boelte, K1
Kolodgie, FD1
Finn, AV1
Biesecker, LG1
McVicar, DW1
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Tang, J3
Chen, Z2
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Xiong, D1
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Niu, PP1
Song, B1
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Chen, D5
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Dymek, B1
Stanczak, PS1
Mazurkiewicz, M1
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Marcotte, DJ1
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Boudot, C1
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Tronnet, A1
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Corvaisier, S1
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Wyllie, S1
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Fang, X1
Gao, M1
Gao, H1
Bi, W1
Tang, H1
Cui, Y1
Zhang, L3
Fan, H1
Yu, H1
Mathison, CJN1
Chianelli, D1
Rucker, PV1
Nelson, J1
Roland, J1
Huang, Z2
Xie, YF1
Epple, R1
Bursulaya, B1
Lee, C1
Gao, MY1
Shaffer, J1
Briones, S1
Sarkisova, Y1
Galkin, A1
Li, N1
Li, C2
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Kasibhatla, S1
Kinyamu-Akunda, J1
Kikkawa, R1
Molteni, V1
Tellew, JE1
Jin, X1
Pang, B1
Liu, Q2
Liu, X3
Huang, Y2
Josephine Fauci, A1
Ma, Y1
Soo Lee, M1
Yuan, W1
Gao, R1
Qi, H1
Zheng, W1
Yang, F2
Chua, H1
Wang, K1
Ou, Y1
Huang, M1
Zhu, Y1
Yu, J1
Tian, J1
Zhao, M1
Hu, J1
Yao, C1
Zhang, B1
Usawachintachit, M1
Tzou, DT1
Washington, SL1
Hu, W1
Chi, T1
Sorensen, MD1
Bailey, MR1
Hsi, RS1
Cunitz, BW1
Simon, J1
Wang, YN1
Dunmire, BL1
Paun, M1
Starr, F1
Lu, W1
Evan, AP1
Harper, JD1
Han, G1
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Davalos, RV1
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Levin, M1
Kaplan, DL1
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Farmany, A1
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Kang, J1
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Cho, JY1
Park, IH1
Kim, HB1
Song, M1
Mfarrej, B1
Jofra, T1
Morsiani, C1
Gagliani, N1
Fousteri, G1
Battaglia, M1
Giuliano, C1
Levinger, I1
Vogrin, S1
Neil, CJ1
Allen, JD1
Lv, Y1
Yuan, R1
Cai, B1
Bahrami, B1
Chowdhury, AH1
Yang, C2
Qiao, Q1
Liu, SF1
Zhang, WH1
Kolano, L1
Knappe, D1
Volke, D1
Sträter, N1
Hoffmann, R1
Coussens, M1
Calders, P1
Lapauw, B1
Celie, B1
Banica, T1
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Pacey, V1
Malfait, F1
Rombaut, L1
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Honjol, Y1
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Gbureck, U1
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Kim, MJ1
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Lee, CS1
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Wang, Q2
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Jena, P1
Sun, Z1
Li, Z2
Liang, H1
Xu, X1
Ma, G1
Huo, X1
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Chace-Donahue, F1
Blum, JL1
Ratner, JR1
Zelikoff, JT1
Schwartzer, JJ1
Fiseha, T1
Tamir, Z1
Yao, W1
Wang, P1
Mi, K1
Cheng, J1
Gu, C1
Huang, J2
Sun, HB1
Xing, WQ1
Liu, XB1
Zheng, Y1
Yang, SJ1
Wang, ZF1
Liu, SL1
Ba, YF1
Zhang, RX1
Liu, BX1
Fan, CC1
Chen, PN1
Liang, GH1
Yu, YK1
Wang, HR1
Li, HM1
Li, ZX1
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Khan, IT1
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Khalique, A1
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Chieppa, M1
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Civardi, E1
Garofoli, F1
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Cena, H1
Kong, D1
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Xue, H1
Zhang, W1
Ruan, Z1
Li, S2
Noer, PR1
Kjaer-Sorensen, K1
Juhl, AK1
Goldstein, A1
Ke, C1
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Kong, F1
Lin, S1
Wang, Z2
Bhattacharya, R1
Mazumder, D1
Yan, X1
Ma, C1
Tang, Y1
Kong, X1
Lu, J1
Zhang, M1
Vital-Jacome, M1
Cazares-Granillo, M1
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Jacob, SI1
Douair, I1
Maron, L1
Ménard, G1
Rusjan, P1
Sabioni, P1
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Boileau, I1
Laveillé, A1
Capet, M1
Duvauchelle, T1
Schwartz, JC1
Robert, P1
Le Foll, B1
Xia, Y1
Chen, S1
Luo, M1
Cai, S1
He, Y2
Garbacz, P1
Misiak, M1
Jackowski, K1
Yuan, Q1
Sherrell, PC1
Chen, J2
Bi, X1
Nutho, B1
Mahalapbutr, P1
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Shigeta, Y1
Hannongbua, S1
Rungrotmongkol, T1
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Kher, R1
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Xue, J1
Wu, P1
Xu, L1
Yuan, Y1
Luo, J1
Ye, S1
Ustriyana, P1
Wei, B1
Raee, E1
Hu, Y1
Wesdemiotis, C1
Sahai, N1
Kaur, A1
Nigam, K1
Srivastava, S1
Tyagi, A1
Dang, S1
Millar, JE1
Bartnikowski, N1
Passmore, MR1
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Malfertheiner, MV1
von Bahr, V1
Redd, MA1
See Hoe, L1
Ki, KK1
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Baillie, JK1
Shekar, K1
Palpant, N1
Suen, JY1
Matthay, MA1
McAuley, DF1
Fraser, JF1
Settles, JA1
Gerety, GF1
Spaepen, E1
Suico, JG1
Child, CJ1
Oh, BL1
Lee, JS1
Lee, EY1
Lee, HY2
Yu, HG1
Leslie, I1
Boos, LA1
Larkin, J1
Pickering, L1
Lima, HK1
Vogel, K1
Hampel, D1
Wagner-Gillespie, M1
Fogleman, AD1
Ferraz, SL1
O'Connor, M1
Mazzucchelli, TG1
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Cheng, H1
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Zhou, YL1
Yan, W1
Luo, L1
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Fan, MZ1
Wang, SR1
Zhao, WG1
Xu, D1
Hassan, HM1
Jiang, Z1
Bachmann, KF1
Haenggi, M1
Jakob, SM1
Takala, J1
Gattinoni, L1
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Banks, L1
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Balcar, VJ1
Šerý, O1
Qiao, L1
Xiong, X1
Peng, X1
Zheng, J1
Duan, J1
Xiao, W1
Zhou, HY1
Sui, ZY1
Zhao, FL1
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Wang, HY1
Han, BH1
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Shasha, Y1
Jincai, W1
Chunyan, L1
Mengya, Y1
Yongli, S1
Rasoanirina, BNV1
Lassoued, MA1
Miladi, K1
Razafindrakoto, Z1
Chaâbane-Banaoues, R1
Ramanitrahasimbola, D1
Cornet, M1
Sfar, S1
Liang, C1
Xing, Q1
Yi, JL1
Zhang, YQ1
Li, CY1
Tang, SJ1
Gao, C1
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Peng, M1
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Zhang, T1
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Liao, CX1
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Jiang, GH1
Wang, XJ1
Wang, BY1
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Yao, T1
Dong, S1
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Operario, D1
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Zaller, N1
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Gómez-Ontañón, E1
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Legge, JS1
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Reviews

7 reviews available for methadone and Respiratory Insufficiency

ArticleYear
Intraoperative methadone administration and postoperative pain control: a systematic review and meta-analysis.
    Pain, 2020, Volume: 161, Issue:2

    Topics: Airway Extubation; Analgesics, Opioid; Humans; Hypoxia; Intraoperative Care; Length of Stay; Methado

2020
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
Quetiapine and other antipsychotics combined with opioids in legal autopsy cases: A random finding or cause of fatal outcome?
    Basic & clinical pharmacology & toxicology, 2021, Volume: 128, Issue:1

    Topics: Adolescent; Adult; Analgesics, Opioid; Animals; Antipsychotic Agents; Arrhythmias, Cardiac; Autopsy;

2021
Effect of intraoperative methadone vs other opioids on postoperative outcomes: a meta-analysis of randomized controlled studies.
    Pain, 2022, 02-01, Volume: 163, Issue:2

    Topics: Airway Extubation; Analgesics, Opioid; Humans; Methadone; Pain, Postoperative; Randomized Controlled

2022
Methadone deaths: risk factors in pain and addicted populations.
    Journal of general internal medicine, 2010, Volume: 25, Issue:4

    Topics: Analgesics, Opioid; Chronic Disease; Death, Sudden, Cardiac; Drug Overdose; Humans; Methadone; Opiat

2010
Management of opioid substitution therapy during medical intervention.
    Internal medicine journal, 2012, Volume: 42, Issue:3

    Topics: Analgesics; Australia; Buprenorphine; Comorbidity; Drug Interactions; Female; Humans; Liver Diseases

2012
[Findings in newborn infants following drug abuse or drug weaning in the mother].
    Der Gynakologe, 1991, Volume: 24, Issue:6

    Topics: Abnormalities, Drug-Induced; Adult; Female; Fetal Growth Retardation; Heroin Dependence; Humans; Inf

1991

Trials

4 trials available for methadone and Respiratory Insufficiency

ArticleYear
Buprenorphine to reverse respiratory depression from methadone overdose in opioid-dependent patients: a prospective randomized trial.
    Critical care (London, England), 2020, 02-07, Volume: 24, Issue:1

    Topics: Adult; Analgesics, Opioid; Buprenorphine; Drug Overdose; Female; Humans; Male; Methadone; Middle Age

2020
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
Comparison of Two Naloxone Regimens in Opioid-dependent Methadoneoverdosed Patients: A Clinical Trial Study.
    Current clinical pharmacology, 2017, Volume: 12, Issue:4

    Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Overdose; Female

2017
Opiate detoxification under anesthesia: no apparent benefit but suppression of thyroid hormones and risk of pulmonary and renal failure.
    Journal of toxicology. Clinical toxicology, 1999, Volume: 37, Issue:1

    Topics: Acute Kidney Injury; Adult; Anesthesia; Codeine; Female; Heroin Dependence; Humans; Male; Methadone;

1999

Other Studies

40 other studies available for methadone and Respiratory Insufficiency

ArticleYear
Undetected Respiratory Depression in People with Opioid Use Disorder.
    Drug and alcohol dependence, 2022, 05-01, Volume: 234

    Topics: Analgesics, Opioid; Buprenorphine; Carbon Dioxide; Drug Overdose; Humans; Methadone; Opiate Substitu

2022
Prediction of postoperative respiratory depression and respiratory complications in patients on preoperative methadone.
    Journal of anesthesia, 2023, Volume: 37, Issue:1

    Topics: Humans; Methadone; Postoperative Complications; Respiration Disorders; Respiratory Insufficiency; Re

2023
Assessment of the potential of novel and classical opioids to induce respiratory depression in mice.
    British journal of pharmacology, 2023, Volume: 180, Issue:24

    Topics: Analgesics, Opioid; Animals; HEK293 Cells; Humans; Male; Methadone; Mice; Morphine; Oxycodone; Respi

2023
Naloxone should remain the appropriate antidote to treat opioid overdose.
    Critical care (London, England), 2020, 04-28, Volume: 24, Issue:1

    Topics: Analgesics, Opioid; Antidotes; Buprenorphine; Drug Overdose; Humans; Methadone; Naloxone; Prospectiv

2020
Opioid Use Disorder and COVID-19: Biological Plausibility for Worsened Outcomes.
    Substance use & misuse, 2020, Volume: 55, Issue:11

    Topics: Adaptive Immunity; Analgesics, Opioid; Arrhythmias, Cardiac; Betacoronavirus; Coronavirus Infections

2020
Clinical characteristics and time trends of hospitalized methadone exposures in the United States based on the Toxicology Investigators Consortium (ToxIC) case registry: 2010-2017.
    BMC pharmacology & toxicology, 2020, 07-22, Volume: 21, Issue:1

    Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Child; Child, Preschool; Coma; Drug Overdose; Female; H

2020
Risk factors for severe respiratory depression from prescription opioid overdose.
    Addiction (Abingdon, England), 2018, Volume: 113, Issue:1

    Topics: Adult; Age Factors; Analgesics, Opioid; Cohort Studies; Drug Overdose; Emergency Service, Hospital;

2018
Be careful of lies: a six-year-old boy with respiratory distress and decreased level of consciousness.
    Acta medica Iranica, 2014, Volume: 52, Issue:6

    Topics: Autistic Disorder; Child; Consciousness; Diagnosis, Differential; Humans; Male; Methadone; Narcotics

2014
Accidental methadone intoxication masquerading as asthma exacerbation with respiratory arrest in a six-year-old boy.
    Delaware medical journal, 2015, Volume: 87, Issue:5

    Topics: Asthma; Bradycardia; Child; Diagnosis, Differential; Drug Overdose; Humans; Male; Methadone; Naloxon

2015
Intravenous Buprenorphine: A Substitute for Naloxone in Methadone-Overdosed Patients?
    Annals of emergency medicine, 2017, Volume: 69, Issue:6

    Topics: Administration, Intravenous; Buprenorphine; Drug Overdose; Humans; Male; Methadone; Naloxone; Narcot

2017
S-Methadone augments R-methadone induced respiratory depression in the neonatal guinea pig.
    Respiratory physiology & neurobiology, 2009, Dec-31, Volume: 169, Issue:3

    Topics: Age Factors; Analgesics, Opioid; Analysis of Variance; Animals; Animals, Newborn; Disease Models, An

2009
Characteristics and comparative severity of respiratory response to toxic doses of fentanyl, methadone, morphine, and buprenorphine in rats.
    Toxicology letters, 2009, Dec-15, Volume: 191, Issue:2-3

    Topics: Animals; Blood Gas Analysis; Buprenorphine; Catheterization; Fentanyl; Lactic Acid; Male; Methadone;

2009
Postnatal methadone withdrawal syndrome: hair analysis for detecting chronic exposure.
    Acta paediatrica (Oslo, Norway : 1992), 2010, Volume: 99, Issue:2

    Topics: Gas Chromatography-Mass Spectrometry; Hair; Heroin Dependence; Humans; Immunoassay; Infant; Lethargy

2010
Mechanisms of respiratory insufficiency induced by methadone overdose in rats.
    Addiction biology, 2010, Volume: 15, Issue:1

    Topics: Acidosis, Respiratory; Animals; Dose-Response Relationship, Drug; Drug Overdose; Exhalation; Hypoxia

2010
Withdrawal treatment with clonidine after prolonged use of chloral hydrate in a pediatric intensive care patient.
    Paediatric anaesthesia, 2011, Volume: 21, Issue:10

    Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Chloral Hydrate; Clonidine; Fentanyl; Humans; Hypnoti

2011
Survey of methadone-drug interactions among patients of methadone maintenance treatment program in Taiwan.
    Substance abuse treatment, prevention, and policy, 2012, Mar-20, Volume: 7

    Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Arrhythmias, Cardiac; Drug Interactions; Female;

2012
Respiratory failure caused by a suspicious white powder: a case report of intentional methadone poisoning in an infant.
    Pediatric emergency care, 2012, Volume: 28, Issue:9

    Topics: Child Abuse; Humans; Infant; Infant, Newborn; Male; Methadone; Narcotics; Neonatal Abstinence Syndro

2012
Use of radiotelemetry to evaluate respiratory depression produced by chronic methadone administration.
    European journal of pharmacology, 2004, Jan-26, Volume: 484, Issue:2-3

    Topics: Animals; Heart Rate; Infusion Pumps, Implantable; Male; Methadone; Motor Activity; Rats; Rats, Sprag

2004
[Preclinical management of accidental methadone intoxication of a 4-year-old girl. Antagonist or intubation?].
    Der Anaesthesist, 2004, Volume: 53, Issue:10

    Topics: Analgesics, Opioid; Child, Preschool; Coma; Emergency Medical Services; Female; Humans; Intubation,

2004
Reversal of morphine, methadone and heroin induced effects in mice by naloxone methiodide.
    Life sciences, 2006, Jan-11, Volume: 78, Issue:7

    Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Drug Interactions; Female; Heroin; Male; Methad

2006
Ventilatory responses to hypoxia and hypercapnia in stable methadone maintenance treatment patients.
    Chest, 2005, Volume: 128, Issue:3

    Topics: Adult; Female; Heroin Dependence; Humans; Hypercapnia; Hypoxia; Male; Methadone; Narcotics; Pulmonar

2005
Methadone-induced respiratory depression in a patient with a history of alcoholism.
    Journal of palliative medicine, 2005, Volume: 8, Issue:5

    Topics: Aged; Alcoholism; Analgesics, Opioid; Back Pain; Drug Interactions; Drug Monitoring; Humans; Male; M

2005
Methadone-induced respiratory depression after discontinuing carbamazepine administration.
    Journal of pain and symptom management, 2006, Volume: 32, Issue:2

    Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Carbamazepine; Female; Humans; Methadone; Middle Aged;

2006
Case report: quantification of methadone-induced respiratory depression using toxicokinetic/toxicodynamic relationships.
    Critical care (London, England), 2007, Volume: 11, Issue:1

    Topics: Adult; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Infusions, Intravenous; Isomer

2007
Could pharmacogenetic data explain part of the interindividual sensitivity to methadone-induced respiratory depression?
    Critical care (London, England), 2007, Volume: 11, Issue:1

    Topics: Cytochrome P-450 Enzyme System; Humans; Methadone; Narcotics; Polymorphism, Genetic; Receptors, Opio

2007
Methadone-induced respiratory depression in the neonatal guinea pig.
    Pediatric pulmonology, 2007, Volume: 42, Issue:12

    Topics: Animals; Animals, Newborn; Blood Gas Analysis; Breath Tests; Carbon Dioxide; Disease Models, Animal;

2007
The safety of methadone hydrochloride.
    Expert opinion on drug safety, 2008, Volume: 7, Issue:1

    Topics: Animals; Humans; Methadone; Opioid-Related Disorders; Pain; Respiratory Insufficiency

2008
Sudden infant death.
    Scientific American, 1980, Volume: 242, Issue:4

    Topics: Adipose Tissue; Adipose Tissue, Brown; Carotid Body; Erythrocytes, Abnormal; Female; Humans; Hypoxia

1980
The effect of changes in gastric pH induced by omeprazole on the absorption and respiratory depression of methadone.
    Biopharmaceutics & drug disposition, 1996, Volume: 17, Issue:7

    Topics: Administration, Oral; Animals; Area Under Curve; Drug Interactions; Female; Gastric Mucosa; Hydrogen

1996
Coma, myalagia and hypoxia.
    Postgraduate medical journal, 1996, Volume: 72, Issue:852

    Topics: Adult; Coma; Humans; Male; Methadone; Respiratory Insufficiency; Rhabdomyolysis

1996
Methadone, ciprofloxacin, and adverse drug reactions.
    Lancet (London, England), 2000, Dec-16, Volume: 356, Issue:9247

    Topics: Adult; Analgesics, Opioid; Anti-Infective Agents; Ciprofloxacin; Confusion; Cytochrome P-450 CYP1A2

2000
Nervous regulation of breathing in opiate dependent patient. Part II. Respiratory system efficiency and breathing regulation of persons classified to the methadone maintenance treatment.
    Przeglad lekarski, 2000, Volume: 57, Issue:10

    Topics: Adult; Female; Heroin Dependence; Humans; Male; Methadone; Morphine Dependence; Narcotics; Pons; Res

2000
Methadone and fluconazole: respiratory depression by drug interaction.
    Journal of pain and symptom management, 2002, Volume: 23, Issue:2

    Topics: Analgesics, Opioid; Antifungal Agents; Drug Interactions; Fluconazole; Humans; Male; Methadone; Midd

2002
Treating heroin overdose.
    American family physician, 1975, Volume: 11, Issue:2

    Topics: Arrhythmias, Cardiac; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Emer

1975
Infrequent neonatal opiate withdrawal following maternal methadone detoxification during pregnancy.
    Journal of perinatal medicine, 1990, Volume: 18, Issue:2

    Topics: Adult; Birth Weight; Embryonic and Fetal Development; Female; Humans; Infant, Newborn; Maternal-Feta

1990
An apparent epidemic: methadone poisoning in children.
    Clinical toxicology, 1973, Volume: 6, Issue:2

    Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Ipecac; Male; Methadone; Nalorphine; Po

1973
Postoperative ventilatory failure in a patient with primary alveolar hypoventilation. A case report.
    British journal of anaesthesia, 1973, Volume: 45, Issue:1

    Topics: Appendectomy; Carbon Dioxide; Cheyne-Stokes Respiration; Female; Humans; Hydrogen-Ion Concentration;

1973
Fatal methadone poisoning in children: report of four cases.
    Journal of forensic sciences, 1973, Volume: 18, Issue:2

    Topics: Autopsy; Child, Preschool; Female; Heroin Dependence; Humans; Infant; Intubation, Intratracheal; Mal

1973
Childhood poisoning. An unfortunate consequence of methadone availability.
    JAMA, 1972, Jan-17, Volume: 219, Issue:3

    Topics: Child; Child, Preschool; Female; Gastric Lavage; Humans; Infant; Injections, Intravenous; Intubation

1972
The hazard of narcotics in the home: accidental ingestion by infants and young children.
    The Journal of pediatrics, 1971, Volume: 79, Issue:4

    Topics: Accidents, Home; Child; Child, Preschool; Female; Heroin; Humans; Infant; Male; Methadone; Nalorphin

1971