methadone has been researched along with Respiratory Distress Syndrome, Newborn in 12 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Respiratory Distress Syndrome, Newborn: A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report here the case of an infant who developed life-threatening rigid-chest syndrome after receiving an accidental overdose of methadone." | 7.76 | Methadone-induced rigid-chest syndrome after substantial overdose. ( Hack, RA; Lynch, RE, 2010) |
| "The course of pregnancy and delivery in 28 women under closely supervised methadone maintenance (group 1) was compared with that of 57 women using heroin or methadone under less controlled circumstances (group 2) and with that of 30 women free of mood-altering medications (group 3)." | 7.65 | Narcotic dependency in pregnancy. Methadone maintenance compared to use of street drugs. ( Adamsons, K; Stimmel, B, 1976) |
| "Buprenorphine appears to have an acceptable safety profile for use during pregnancy." | 5.16 | Infections and obstetric outcomes in opioid-dependent pregnant women maintained on methadone or buprenorphine. ( Baxter, JK; Coyle, MG; Heil, SH; Holbrook, AM; Jones, HE; Kaltenbach, K; Martin, PR; Stine, SM, 2012) |
| "We report here the case of an infant who developed life-threatening rigid-chest syndrome after receiving an accidental overdose of methadone." | 3.76 | Methadone-induced rigid-chest syndrome after substantial overdose. ( Hack, RA; Lynch, RE, 2010) |
| "This report describes a case in which cocaine abuse during pregnancy was related temporally to abruptio placentae, preterm labour and to rapid delivery." | 3.67 | Perinatal cocaine intoxication. ( Collins, E; Hardwick, RJ; Jeffery, H, 1989) |
| "The course of pregnancy and delivery in 28 women under closely supervised methadone maintenance (group 1) was compared with that of 57 women using heroin or methadone under less controlled circumstances (group 2) and with that of 30 women free of mood-altering medications (group 3)." | 3.65 | Narcotic dependency in pregnancy. Methadone maintenance compared to use of street drugs. ( Adamsons, K; Stimmel, B, 1976) |
| "Infant delirium is an under-recognized clinical entity in neonatal intensive care, and earlier identification and treatment could minimize morbidities associated with this condition." | 1.46 | A case of infant delirium in the neonatal intensive care unit. ( Bidegain, M; Cotten, CM; Edwards, LE; Hornik, CD; Hutchison, LB; Smith, PB, 2017) |
| "Illicit drug abuse, as well as smoking, are known risk factors in the development of intrauterine growth retardation." | 1.28 | [Drug dependence, smoking and fetal growth retardation]. ( Hanzal, E; Hoffmann, G; Kölbl, H, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (58.33) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Edwards, LE | 1 |
| Hutchison, LB | 1 |
| Hornik, CD | 1 |
| Smith, PB | 1 |
| Cotten, CM | 1 |
| Bidegain, M | 1 |
| Lynch, RE | 1 |
| Hack, RA | 1 |
| Catlin, EA | 1 |
| Warren, HS | 1 |
| Shailam, R | 1 |
| Lahoud-Rahme, M | 1 |
| Lew, M | 1 |
| Holbrook, AM | 1 |
| Baxter, JK | 1 |
| Jones, HE | 1 |
| Heil, SH | 1 |
| Coyle, MG | 1 |
| Martin, PR | 1 |
| Stine, SM | 1 |
| Kaltenbach, K | 1 |
| Connaughton, JF | 1 |
| Reeser, D | 1 |
| Schut, J | 1 |
| Finnegan, LP | 1 |
| Stimmel, B | 1 |
| Adamsons, K | 1 |
| Vargas, GC | 1 |
| Pildes, RS | 1 |
| Vidyasagar, D | 1 |
| Keith, LG | 1 |
| Hanzal, E | 1 |
| Hoffmann, G | 1 |
| Kölbl, H | 1 |
| Collins, E | 1 |
| Hardwick, RJ | 1 |
| Jeffery, H | 1 |
| Singh, EJ | 1 |
| Zuspan, FP | 1 |
| Schaaf, JT | 1 |
| Spivack, ML | 1 |
| Rath, GS | 1 |
| Snider, GL | 1 |
| Scott, NR | 1 |
| Ryan, JJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Maternal Opioid Treatment: Human Experimental Research[NCT00271219] | Phase 3 | 175 participants (Actual) | Interventional | 2005-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00271219)
Timeframe: birth
| Intervention | cm (Mean) |
|---|---|
| A Methadone | 33.0 |
| B Buprenorphine | 33.8 |
(NCT00271219)
Timeframe: delivery until hospital discharge (min=2 days, max=79 days)
| Intervention | days (Mean) |
|---|---|
| A Methadone | 17.5 |
| B Buprenorphine | 10.0 |
NAS was measured with the MOTHER NAS scale, which includes 28 items, 19 of which are used for scoring and medication decisions. Scores can range from 0 to 42, with higher scores indicating more severe withdrawal. (NCT00271219)
Timeframe: minimum twice daily from birth until NAS no longer measured (min=10 days)
| Intervention | Score on the scale (Mean) |
|---|---|
| A Methadone | 12.8 |
| B Buprenorphine | 11.0 |
(NCT00271219)
Timeframe: monthly from study entry until discontinuation or delivery (min=29 days, max=239 days)
| Intervention | percentage of HIV risk behaviors (Number) |
|---|---|
| A Methadone | NA |
| B Buprenorphine | NA |
Pregnant women maintained on an opioid agonist medication may require upward adjustment to their medication during the course of pregnant. The Dose Adequacy Measure represented a recordation of dosing adjustments during the course of the study. (NCT00271219)
Timeframe: from study entry until discontinuation or delivery (min=29 days, max=239 days)
| Intervention | dose increase per trimester (Number) |
|---|---|
| A Methadone | NA |
| B Buprenorphine | NA |
The Addiction Severity Index is a structured clinical interview that assesses problem severity in 7 areas of functioning: alcohol use, drug use, medical, legal, employment, psychosocial, and psychiatric status. Each area of functioning yields a composite scale score between 0 and 1, with higher scores indicating greater problem severity in that area. Only the psychosocial index was examined in this study. (NCT00271219)
Timeframe: at delivery
| Intervention | Score on the scale (Mean) |
|---|---|
| Methadone | .014 |
| Buprenorphine | .088 |
(NCT00271219)
Timeframe: monthly from study entry until discontinuation or delivery (min=29 days, max=239 days)
| Intervention | percentage of drug use (Number) |
|---|---|
| A Methadone | NA |
| B Buprenorphine | NA |
Neonatal abstinence syndrome (NAS) characterized by hyperirritability of the central nervous system and dysfunction in the autonomic nervous system, gastrointestinal tract, and respiratory system.11 When left untreated, NAS can result in serious illness (e.g., diarrhea, feeding difficulties, weight loss, and seizures) and death. (NCT00271219)
Timeframe: From birth until hospital discharge (min=4 days, max=10, depending on site)
| Intervention | participants (Number) |
|---|---|
| A Methadone | 41 |
| B Buprenorphine | 27 |
Total amount in mg (NCT00271219)
Timeframe: Start of NAS treatment until discontinuation of NAS treatment (min=0 days, max=76 days)
| Intervention | mg (Mean) |
|---|---|
| A Methadone | 10.4 |
| B Buprenorphine | 1.1 |
1 trial available for methadone and Respiratory Distress Syndrome, Newborn
| Article | Year |
|---|---|
Infections and obstetric outcomes in opioid-dependent pregnant women maintained on methadone or buprenorphine.
Topics: Adolescent; Adult; Analgesics, Opioid; Analysis of Variance; Buprenorphine; Communicable Diseases; F | 2012 |
11 other studies available for methadone and Respiratory Distress Syndrome, Newborn
| Article | Year |
|---|---|
A case of infant delirium in the neonatal intensive care unit.
Topics: Amines; Analgesics, Opioid; Anti-Anxiety Agents; Cardiac Catheterization; Cyclohexanecarboxylic Acid | 2017 |
Methadone-induced rigid-chest syndrome after substantial overdose.
Topics: Drug Administration Schedule; Drug Overdose; Fentanyl; Follow-Up Studies; Humans; Infant, Newborn; I | 2010 |
Case records of the Massachusetts General Hospital. Case 19-2012. A premature newborn boy with respiratory distress.
Topics: Adrenal Glands; Diagnosis, Differential; Echocardiography; Fatal Outcome; Herpes Simplex; Humans; In | 2012 |
Perinatal addiction: outcome and management.
Topics: Abruptio Placentae; Apgar Score; Breech Presentation; Cesarean Section; Counseling; Female; Fetal Gr | 1977 |
Narcotic dependency in pregnancy. Methadone maintenance compared to use of street drugs.
Topics: Adolescent; Adult; Apgar Score; Birth Weight; Child, Preschool; Female; Follow-Up Studies; Heroin De | 1976 |
Effect of maternal heroin addiction on 67 liveborn neonates. Withdrawal symptoms, small body size, and small head circumference were frequent findings.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Birth Weight; Blood Glucose; Cephalomet | 1975 |
[Drug dependence, smoking and fetal growth retardation].
Topics: Acid-Base Equilibrium; Adult; Birth Weight; Drug Synergism; Female; Fetal Growth Retardation; Gestat | 1992 |
Perinatal cocaine intoxication.
Topics: Adult; Cocaine; Female; Follow-Up Studies; Humans; Infant, Newborn; Male; Methadone; Neonatal Abstin | 1989 |
Rapid phospholipid test for fetal pulmonary maturity.
Topics: Amniotic Fluid; Chromatography, Paper; Densitometry; Female; Humans; Infant, Newborn; Methadone; Pho | 1974 |
Pulmonary edema and adult respiratory distress syndrome following methadone abuse.
Topics: Adolescent; Humans; Hypoxia; Infant, Newborn; Injections, Intravenous; Male; Methadone; Pneumothorax | 1973 |
Clinical evaluation of pregnant methadone maintenance patients and their newborn infants.
Topics: Adolescent; Adult; Community Health Services; Evaluation Studies as Topic; Female; Heroin Dependence | 1973 |