methadone has been researched along with Renal Insufficiency in 3 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methadone is a synthetic opioid that is effective for the relief of moderate-to-severe pain and for the treatment of opioid dependence." | 4.82 | Pharmacokinetics of methadone. ( Kern, SE; Lugo, RA; Satterfield, KL, 2005) |
| "Our patient simultaneously had kidney failure, rhabdomyolysis, and permanent hearing loss following methadone poisoning." | 3.91 | Methadone associated long term hearing loss and nephrotoxicity; a case report and literature review. ( Brent, J; Ghasemi, S; Izadpanahi, S; Mehrpour, O; Yaghoubi, MA, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ghasemi, S | 1 |
| Izadpanahi, S | 1 |
| Yaghoubi, MA | 1 |
| Brent, J | 1 |
| Mehrpour, O | 1 |
| Lugo, RA | 1 |
| Satterfield, KL | 1 |
| Kern, SE | 1 |
| Justo, D | 1 |
| Gal-Oz, A | 1 |
| Paran, Y | 1 |
| Goldin, Y | 1 |
| Zeltser, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Influence of Aging on Perioperative Methadone Dosing[NCT04526236] | Phase 4 | 60 participants (Actual) | Interventional | 2019-09-03 | Completed | ||
| Single-dose Intraoperative Methadone for Early Ambulation and Sustained Pain Control in Spinal Fusion Surgery Patients[NCT02989597] | Phase 4 | 10 participants (Actual) | Interventional | 2017-07-29 | Terminated (stopped due to Due to personnel loss and logistical issues the study was unable to be completed as planned.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for methadone and Renal Insufficiency
| Article | Year |
|---|---|
Pharmacokinetics of methadone.
Topics: Aged; Analgesics, Opioid; Area Under Curve; Biological Availability; Child; Cytochrome P-450 Enzyme | 2005 |
Pharmacokinetics of methadone.
Topics: Aged; Analgesics, Opioid; Area Under Curve; Biological Availability; Child; Cytochrome P-450 Enzyme | 2005 |
Pharmacokinetics of methadone.
Topics: Aged; Analgesics, Opioid; Area Under Curve; Biological Availability; Child; Cytochrome P-450 Enzyme | 2005 |
Pharmacokinetics of methadone.
Topics: Aged; Analgesics, Opioid; Area Under Curve; Biological Availability; Child; Cytochrome P-450 Enzyme | 2005 |
2 other studies available for methadone and Renal Insufficiency
| Article | Year |
|---|---|
Methadone associated long term hearing loss and nephrotoxicity; a case report and literature review.
Topics: Adult; Analgesics, Opioid; Hearing Loss, Sensorineural; Humans; Male; Methadone; Renal Insufficiency | 2019 |
Methadone-associated Torsades de Pointes (polymorphic ventricular tachycardia) in opioid-dependent patients.
Topics: Adult; Female; Heroin Dependence; Humans; Hypokalemia; Methadone; Middle Aged; Narcotics; Renal Insu | 2006 |