methadone has been researched along with Preterm Birth in 19 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The preterm birth rate among individuals using buprenorphine for opioid use disorder (22." | 8.12 | Risk factors for preterm birth among gravid individuals receiving buprenorphine for opioid use disorder. ( Abdelwahab, M; Cleary, EM; Petrich, M; Rood, KM; Walker, E; Wang, H, 2022) |
| " In early pregnancy, 10,704 pregnant persons were exposed to buprenorphine and 4387 to methadone." | 8.12 | Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy. ( Bateman, BT; Connery, HS; Davis, JM; Gray, KJ; Hernández-Díaz, S; Huybrechts, KF; Jones, HE; Lester, B; Mogun, H; Straub, L; Suarez, EA; Terplan, M, 2022) |
| "Methadone is standard pharmacotherapy for opioid-dependent pregnant women, yet the relationship between maternal methadone dose and neonatal abstinence syndrome (NAS) severity is still unclear." | 7.76 | Prenatal methadone exposure, meconium biomarker concentrations and neonatal abstinence syndrome. ( Choo, RE; Concheiro, M; Elko, A; Gray, TR; Huestis, MA; Jansson, LM; Jones, HE; Williams, E, 2010) |
| "Prior studies noted elevated preterm birth (PTB) rates among opiate-addicted women treated with methadone." | 7.75 | Risk factors for preterm birth among opiate-addicted gravid women in a methadone treatment program. ( Almario, CV; Baxter, JK; Berghella, V; Dysart, KC; Seligman, NS, 2009) |
| "Moderately strong evidence indicates lower risk of preterm birth, greater birth weight and larger head circumference with buprenorphine treatment of maternal opioid use disorder during pregnancy compared with methadone treatment, and no greater harms." | 4.93 | Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child. ( Amick, HR; Jones, HE; Joyce, AR; Kim, MM; Mann, AL; Murrelle, EL; Zedler, BK, 2016) |
| "Of 400 eligible pregnancies, 85 and 137 individuals received buprenorphine and methadone, respectively, during early pregnancy." | 4.31 | Comparative Safety Analysis of Opioid Agonist Treatment in Pregnant Women with Opioid Use Disorder: A Population-Based Study. ( Brothers, TN; Hartzema, A; Lewkowitz, AK; Meador, KJ; Pawasauskas, J; Quilliam, BJ; Wang, S; Ward, KE; Wen, X, 2023) |
| "The preterm birth rate among individuals using buprenorphine for opioid use disorder (22." | 4.12 | Risk factors for preterm birth among gravid individuals receiving buprenorphine for opioid use disorder. ( Abdelwahab, M; Cleary, EM; Petrich, M; Rood, KM; Walker, E; Wang, H, 2022) |
| " In early pregnancy, 10,704 pregnant persons were exposed to buprenorphine and 4387 to methadone." | 4.12 | Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy. ( Bateman, BT; Connery, HS; Davis, JM; Gray, KJ; Hernández-Díaz, S; Huybrechts, KF; Jones, HE; Lester, B; Mogun, H; Straub, L; Suarez, EA; Terplan, M, 2022) |
| "In our theoretical cohort, treatment of OUD with buprenorphine during pregnancy resulted in 2413 fewer cases of neonatal opioid withdrawal syndrome, 1089 fewer preterm births, 299 fewer cases of fetal growth restriction, 32 fewer stillbirths, and 13 fewer cases of cerebral palsy compared to methadone treatment." | 4.12 | Cost effectiveness of buprenorphine vs. methadone for pregnant people with opioid use disorder. ( Caughey, AB; Hersh, AR; John, C; Robin, AM, 2022) |
| " Treatment with buprenorphine-naloxone (compared with methadone) reduced odds of each outcome including neonatal abstinence syndrome (adjusted odds ratio: 0." | 4.02 | Opioid Use Disorder and Perinatal Outcomes. ( Homayra, F; Marchand, C; Mead, A; Min, JE; Ng, J; Nosyk, B; Piske, M; Woolner, M; Zhou, H, 2021) |
| "Two national cohorts of women receiving opioid maintenance treatment during pregnancy showed small but not statistically significant differences in neonatal outcomes in favour of buprenorphine compared with methadone." | 3.88 | Neonatal outcomes after fetal exposure to methadone and buprenorphine: national registry studies from the Czech Republic and Norway. ( Engeland, A; Gabrhelík, R; Handal, M; Lund, IO; Mravčík, V; Nechanská, B; Skurtveit, S, 2018) |
| "The purpose of this study was to examine the relationship among methadone maintenance treatment, perinatal outcomes, and neonatal abstinence syndrome." | 3.77 | Methadone and perinatal outcomes: a retrospective cohort study. ( Cleary, BJ; Donnelly, JM; Fahey, T; Gallagher, PJ; Murphy, DJ; Strawbridge, JD; White, MJ, 2011) |
| "Methadone is standard pharmacotherapy for opioid-dependent pregnant women, yet the relationship between maternal methadone dose and neonatal abstinence syndrome (NAS) severity is still unclear." | 3.76 | Prenatal methadone exposure, meconium biomarker concentrations and neonatal abstinence syndrome. ( Choo, RE; Concheiro, M; Elko, A; Gray, TR; Huestis, MA; Jansson, LM; Jones, HE; Williams, E, 2010) |
| "Prior studies noted elevated preterm birth (PTB) rates among opiate-addicted women treated with methadone." | 3.75 | Risk factors for preterm birth among opiate-addicted gravid women in a methadone treatment program. ( Almario, CV; Baxter, JK; Berghella, V; Dysart, KC; Seligman, NS, 2009) |
| "Longer duration of medication for opioid use disorder use during pregnancy appears to be associated with improved maternal and perinatal outcomes." | 1.62 | Outcomes associated with the use of medications for opioid use disorder during pregnancy. ( Chen, Q; James, AE; Jarlenski, MP; Kelley, D; Kim, JY; Krans, EE; Rothenberger, SD, 2021) |
| "Preterm birth is associated with less risk of neonatal abstinence syndrome (NAS)." | 1.48 | The Role of Preterm Birth in the Association Between Opioid Maintenance Therapy and Neonatal Abstinence Syndrome. ( Bodnar, LM; Caritis, SN; Lemon, LS; Naimi, A; Platt, RW; Venkataramanan, R, 2018) |
| "Methadone treatment was not found to increase the treatment requirement for neonatal abstinence syndrome compared with those using heroin only (P = 0." | 1.39 | Predictors of neonatal outcomes amongst a methadone- and/or heroin-dependent population referred to a multidisciplinary Perinatal and Family Drug Health Service. ( Buckley, V; Haber, P; Razaghi, A, 2013) |
| "During pregnancy, drug addiction represents one of the most dangerous situations." | 1.35 | Drug addiction during pregnancy: correlations between the placental health and the newborn's outcome - elaboration of a predictive score. ( Boldrini, A; Cuttano, A; Domenici, C; Ghirri, P; Nardini, V; Varese, L, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 9 (47.37) | 24.3611 |
| 2020's | 6 (31.58) | 2.80 |
| Authors | Studies |
|---|---|
| Piske, M | 1 |
| Homayra, F | 1 |
| Min, JE | 1 |
| Zhou, H | 1 |
| Marchand, C | 1 |
| Mead, A | 1 |
| Ng, J | 1 |
| Woolner, M | 1 |
| Nosyk, B | 1 |
| Abdelwahab, M | 1 |
| Petrich, M | 1 |
| Wang, H | 1 |
| Walker, E | 1 |
| Cleary, EM | 1 |
| Rood, KM | 1 |
| Suarez, EA | 3 |
| Huybrechts, KF | 3 |
| Straub, L | 3 |
| Hernández-Díaz, S | 3 |
| Jones, HE | 6 |
| Connery, HS | 3 |
| Davis, JM | 3 |
| Gray, KJ | 3 |
| Lester, B | 3 |
| Terplan, M | 3 |
| Mogun, H | 3 |
| Bateman, BT | 3 |
| Wang, S | 1 |
| Meador, KJ | 1 |
| Pawasauskas, J | 1 |
| Lewkowitz, AK | 1 |
| Ward, KE | 1 |
| Brothers, TN | 1 |
| Hartzema, A | 1 |
| Quilliam, BJ | 1 |
| Wen, X | 1 |
| Robin, AM | 1 |
| Hersh, AR | 1 |
| John, C | 1 |
| Caughey, AB | 1 |
| Krans, EE | 1 |
| Kim, JY | 1 |
| Chen, Q | 1 |
| Rothenberger, SD | 1 |
| James, AE | 1 |
| Kelley, D | 1 |
| Jarlenski, MP | 1 |
| Lemon, LS | 1 |
| Naimi, A | 1 |
| Caritis, SN | 1 |
| Platt, RW | 1 |
| Venkataramanan, R | 1 |
| Bodnar, LM | 1 |
| Nechanská, B | 1 |
| Mravčík, V | 1 |
| Skurtveit, S | 1 |
| Lund, IO | 1 |
| Gabrhelík, R | 1 |
| Engeland, A | 1 |
| Handal, M | 1 |
| Wang, MJ | 1 |
| Kuper, SG | 1 |
| Sims, B | 1 |
| Paddock, CS | 1 |
| Dantzler, J | 1 |
| Muir, S | 1 |
| Harper, LM | 1 |
| Buckley, V | 1 |
| Razaghi, A | 1 |
| Haber, P | 1 |
| Zedler, BK | 1 |
| Mann, AL | 1 |
| Kim, MM | 1 |
| Amick, HR | 1 |
| Joyce, AR | 1 |
| Murrelle, EL | 1 |
| Gibson, KS | 1 |
| Stark, S | 1 |
| Kumar, D | 1 |
| Bailit, JL | 1 |
| Almario, CV | 1 |
| Seligman, NS | 1 |
| Dysart, KC | 1 |
| Berghella, V | 1 |
| Baxter, JK | 1 |
| Domenici, C | 1 |
| Cuttano, A | 1 |
| Nardini, V | 1 |
| Varese, L | 1 |
| Ghirri, P | 1 |
| Boldrini, A | 1 |
| Gray, TR | 1 |
| Choo, RE | 1 |
| Concheiro, M | 1 |
| Williams, E | 1 |
| Elko, A | 1 |
| Jansson, LM | 2 |
| Huestis, MA | 1 |
| Cleary, BJ | 1 |
| Donnelly, JM | 1 |
| Strawbridge, JD | 1 |
| Gallagher, PJ | 1 |
| Fahey, T | 1 |
| White, MJ | 1 |
| Murphy, DJ | 1 |
| Kaltenbach, K | 1 |
| Nanovskaya, TN | 1 |
| Nekhayeva, IA | 1 |
| Hankins, GD | 1 |
| Ahmed, MS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Randomized Comparative Effectiveness Clinical Trial of Buprenorphine vs. Methadone for the Treatment of Opioid Dependence in Pregnancy.[NCT03098407] | 55 participants (Actual) | Interventional | 2017-04-20 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for methadone and Preterm Birth
| Article | Year |
|---|---|
Opioid Detoxification in Pregnancy: Systematic Review and Meta-Analysis of Perinatal Outcomes.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence S | 2019 |
Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child.
Topics: Abnormalities, Drug-Induced; Analgesics, Opioid; Birth Weight; Buprenorphine; Female; Fetal Death; F | 2016 |
17 other studies available for methadone and Preterm Birth
| Article | Year |
|---|---|
Opioid Use Disorder and Perinatal Outcomes.
Topics: Adult; Analgesics, Opioid; British Columbia; Buprenorphine; Female; Humans; Incidence; Infant, Newbo | 2021 |
Risk factors for preterm birth among gravid individuals receiving buprenorphine for opioid use disorder.
Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Opioid-Related Disorders; Placenta; Pregn | 2022 |
Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.
Topics: Buprenorphine; Cesarean Section; Cohort Studies; Female; Humans; Infant; Infant, Low Birth Weight; I | 2022 |
Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.
Topics: Buprenorphine; Cesarean Section; Cohort Studies; Female; Humans; Infant; Infant, Low Birth Weight; I | 2022 |
Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.
Topics: Buprenorphine; Cesarean Section; Cohort Studies; Female; Humans; Infant; Infant, Low Birth Weight; I | 2022 |
Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.
Topics: Buprenorphine; Cesarean Section; Cohort Studies; Female; Humans; Infant; Infant, Low Birth Weight; I | 2022 |
Comparative Safety Analysis of Opioid Agonist Treatment in Pregnant Women with Opioid Use Disorder: A Population-Based Study.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence S | 2023 |
Cost effectiveness of buprenorphine vs. methadone for pregnant people with opioid use disorder.
Topics: Analgesics, Opioid; Buprenorphine; Cerebral Palsy; Cost-Benefit Analysis; Female; Fetal Growth Retar | 2022 |
Outcomes associated with the use of medications for opioid use disorder during pregnancy.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant; Infant, Newborn; Methadone; Neonatal Abst | 2021 |
The Role of Preterm Birth in the Association Between Opioid Maintenance Therapy and Neonatal Abstinence Syndrome.
Topics: Adult; Buprenorphine; Female; Humans; Infant, Newborn; Maternal Age; Methadone; Neonatal Abstinence | 2018 |
Neonatal outcomes after fetal exposure to methadone and buprenorphine: national registry studies from the Czech Republic and Norway.
Topics: Abortion, Spontaneous; Adult; Analgesics, Opioid; Apgar Score; Buprenorphine; Czech Republic; Female | 2018 |
Predictors of neonatal outcomes amongst a methadone- and/or heroin-dependent population referred to a multidisciplinary Perinatal and Family Drug Health Service.
Topics: Adult; Child Custody; Female; Gestational Age; Heroin Dependence; Humans; Infant, Low Birth Weight; | 2013 |
The relationship between gestational age and the severity of neonatal abstinence syndrome.
Topics: Adult; Analgesics, Opioid; Female; Gestational Age; Humans; Infant, Newborn; Intensive Care Units, N | 2017 |
Buprenorphine and pregnancy.
Topics: Buprenorphine; Congenital Abnormalities; Female; France; Humans; Infant, Newborn; Methadone; Neonata | 2009 |
Risk factors for preterm birth among opiate-addicted gravid women in a methadone treatment program.
Topics: Adult; Analgesics, Opioid; Comorbidity; Female; Humans; Methadone; Odds Ratio; Opioid-Related Disord | 2009 |
Drug addiction during pregnancy: correlations between the placental health and the newborn's outcome - elaboration of a predictive score.
Topics: Adult; Analgesics, Opioid; Cannabis; Cocaine; Ethanol; Female; Gestational Age; Humans; Infant, Newb | 2009 |
Prenatal methadone exposure, meconium biomarker concentrations and neonatal abstinence syndrome.
Topics: Adult; Analgesics, Opioid; Cocaine; Cocaine-Related Disorders; Female; Gestational Age; Humans; Infa | 2010 |
Methadone and perinatal outcomes: a retrospective cohort study.
Topics: Age Factors; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Methadone; Narcotics | 2011 |
Methadone and perinatal outcomes: another perspective.
Topics: Female; Humans; Methadone; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Opioid-Relat | 2011 |
Transfer of methadone across the dually perfused preterm human placental lobule.
Topics: Female; Gestational Age; Humans; Maternal-Fetal Exchange; Methadone; Organ Culture Techniques; Perfu | 2008 |