methadone has been researched along with Pregnancy in 1026 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methadone use for the management of opioid dependency during pregnancy is commonplace." | 9.41 | Precision dosing of methadone during pregnancy: A pharmacokinetics virtual clinical trials study. ( Badhan, RKS; Gittins, R, 2021) |
| " While methadone-maintenance currently is the standard of care for opioid dependence during pregnancy, research suggests that buprenorphine-maintenance may be associated with shorter infant hospital lengths of stay (LOS) relative to methadone-maintenance." | 9.19 | Design considerations for point-of-care clinical trials comparing methadone and buprenorphine treatment for opioid dependence in pregnancy and for neonatal abstinence syndrome. ( Hall, ES; Lewis, D; Marcotte, M; Theobald, J; Van Hook, J; Wexelblatt, SL; Wilder, C; Winhusen, T, 2014) |
| "To compare the profile of signs of neonatal abstinence syndrome (NAS) in methadone- versus buprenorphine-exposed infants." | 9.16 | Differences in the profile of neonatal abstinence syndrome signs in methadone- versus buprenorphine-exposed neonates. ( Arria, AM; Badger, GJ; Coyle, MG; Gaalema, DE; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; Scott, TL; Stine, SM, 2012) |
| "Methadone, a full mu-opioid agonist, is the recommended treatment for opioid dependence during pregnancy." | 9.14 | Neonatal abstinence syndrome after methadone or buprenorphine exposure. ( Arria, AM; Coyle, MG; Fischer, G; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; O'Grady, KE; Selby, P; Stine, SM, 2010) |
| " Infants born to buprenorphine maintained women are not exposed to a greater proportion of the maternal dose compared with methadone and may be exposed to relatively less of the maternal dose compared with infants born to women maintained on methadone during pregnancy." | 9.14 | (R)- and (S)-methadone and buprenorphine concentration ratios in maternal and umbilical cord plasma following chronic maintenance dosing in pregnancy. ( Foster, DJ; Gordon, AL; Lopatko, OV; Somogyi, AA; White, JM, 2010) |
| "The aim of the study was to evaluate the effect of substitution therapy in heroin addicted pregnant women on the course of pregnancy, perinatal outcomes and course of the neonatal abstinence syndrome." | 9.13 | Prospective randomised comparative study of the effect of buprenorphine, methadone and heroin on the course of pregnancy, birthweight of newborns, early postpartum adaptation and course of the neonatal abstinence syndrome (NAS) in women followed up in the ( Binder, T; Vavrinková, B, 2008) |
| "Though methadone pharmacotherapy is the treatment of choice for opiate-dependence during pregnancy in the USA, most methadone-exposed neonates develop neonatal abstinence syndrome (NAS)." | 9.12 | Maternal vagal tone change in response to methadone is associated with neonatal abstinence syndrome severity in exposed neonates. ( Dipietro, JA; Elko, A; Jansson, LM; Velez, M, 2007) |
| "Treating opioid-addicted women with methadone in pregnancy increased the number of newborns suffering from neonatal abstinence syndrome (NAS)." | 9.11 | Therapy of the neonatal abstinence syndrome with tincture of opium or morphine drops. ( Birkenfeld, L; Hellmich, M; Herkenrath, P; Langenfeld, S; Müller, C; Theisohn, M, 2005) |
| "This study was designed to compare the neonatal abstinence syndrome (NAS) in neonates of methadone and buprenorphine maintained pregnant opioid-dependent women and to provide preliminary safety and efficacy data for a larger multi-center trial." | 9.11 | Buprenorphine versus methadone in the treatment of pregnant opioid-dependent patients: effects on the neonatal abstinence syndrome. ( Chisholm, CA; Choo, RE; Crocetti, M; Dudas, R; Harrow, C; Huestis, MA; Jansson, LM; Jasinski, DR; Johnson, RE; Jones, HE; Lantz, M; Lester, BM; Milio, L; O'Grady, KE, 2005) |
| "To systematically review and meta-analyse studies of neurodevelopmental outcome of children born to mothers prescribed methadone in pregnancy." | 9.01 | Childhood neurodevelopment after prescription of maintenance methadone for opioid dependency in pregnancy: a systematic review and meta-analysis. ( Boardman, JP; Chappell, FM; Hamilton, R; Mactier, H; Monnelly, VJ, 2019) |
| "To compare the effects of morphine and methadone on length of hospital stay (LOS) or treatment (LOT) and adverse effects in infants with neonatal abstinence syndrome (NAS)." | 8.98 | Morphine and Methadone for Neonatal Abstinence Syndrome: A Systematic Review. ( Gregory, PJ; Hein, DJ; Risoldi Cochrane, Z; Slowiczek, L, 2018) |
| "A literature search of PubMed (1966 to March 2016) and EMBASE (1973 to March 2016) was completed using the search terms buprenorphine, methadone, pregnancy, opioid, and neonatal abstinence syndrome Priority was given to randomized controlled trials and trials directly comparing buprenorphine and methadone during pregnancy." | 8.93 | Buprenorphine Versus Methadone for Opioid Dependence in Pregnancy. ( Campbell, K; Crannage, E; Forinash, A; Noormohammadi, A; Shyken, J; Yancey, A, 2016) |
| "Buprenorphine and methadone are opioid-receptor agonists used as opioid substitution therapy during pregnancy to limit exposure of the fetus to cycles of opioid withdrawal and reduce the risk of infectious comorbidities of illicit opioid use." | 8.90 | Buprenorphine and methadone for opioid addiction during pregnancy. ( Mozurkewich, EL; Rayburn, WF, 2014) |
| "Many individuals receiving methadone maintenance treatment (MMT) for opioid addiction also require treatment for acute or chronic pain, and the presence of pain is known to have a negative impact on patient health and function." | 8.89 | Chronic and acute pain and pain management for patients in methadone maintenance treatment. ( Eyler, EC, 2013) |
| "This article provides an overview and discussion of the collective maternal, fetal and neonatal outcome research on women maintained on methadone or buprenorphine during pregnancy." | 8.88 | Methadone and buprenorphine for the management of opioid dependence in pregnancy. ( Finnegan, LP; Jones, HE; Kaltenbach, K, 2012) |
| "To determine if there is a relationship between maternal methadone dose in pregnancy and the diagnosis or medical treatment of neonatal abstinence syndrome (NAS)." | 8.86 | Methadone dose and neonatal abstinence syndrome-systematic review and meta-analysis. ( Clarke, M; Cleary, BJ; Donnelly, J; Fahey, T; Gallagher, PJ; Murphy, DJ; Strawbridge, J, 2010) |
| "Methadone treatment during pregnancy offers overwhelming advantages compared with the less acceptable option of medical detoxification or the unacceptably dangerous option of leaving heroin-addicted women dependent on street drugs." | 8.80 | The methadone-maintained pregnancy. ( Doberczak, TM; Jantunen, M; Kandall, SR; Stein, J, 1999) |
| "Results showed mean reduction in birth weight associated with heroin use: 489 g (95% CI 284-693 g), compared with methadone: 279 g (229-328 g)." | 8.79 | The relationship between maternal use of heroin and methadone and infant birth weight. ( English, DR; Holman, CD; Hulse, GK; Milne, E, 1997) |
| " Illicit drug use during the pregnancy was common in all groups, but in the methadone group it was most common (p = 0." | 8.31 | Buprenorphine-naloxone, buprenorphine, and methadone throughout pregnancy in maternal opioid use disorder. ( Kahila, HK; Kanervo, MM; Nikkola, EM; Rantakari, KM; Tupola, SJ, 2023) |
| " Methadone is recommended for the treatment of opioid use disorders during pregnancy, increasing the number of children prenatally exposed to long-acting opioids." | 8.31 | Methadone administered to rat dams during pregnancy and lactation affects the circadian rhythms of their pups. ( Bendová, Z; Novotný, J; Pačesová, D; Spišská, V, 2023) |
| "Methadone is used as a substitute for illicit opioids during pregnancy." | 8.31 | Long-Term Visual and Neurodevelopmental Outcomes in Two Children with Congenital Nystagmus Secondary to Methadone Exposure In utero. ( Accorsi, P; Fazzi, E; Franzoni, A; Galli, J; Loi, E; Micheletti, S; Pansera, L, 2023) |
| "The preterm birth rate among individuals using buprenorphine for opioid use disorder (22." | 8.12 | Risk factors for preterm birth among gravid individuals receiving buprenorphine for opioid use disorder. ( Abdelwahab, M; Cleary, EM; Petrich, M; Rood, KM; Walker, E; Wang, H, 2022) |
| " In early pregnancy, 10,704 pregnant persons were exposed to buprenorphine and 4387 to methadone." | 8.12 | Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy. ( Bateman, BT; Connery, HS; Davis, JM; Gray, KJ; Hernández-Díaz, S; Huybrechts, KF; Jones, HE; Lester, B; Mogun, H; Straub, L; Suarez, EA; Terplan, M, 2022) |
| "The aim of the study is to assess the correlation between maternal methadone dose and severity of neonatal abstinence syndrome (NAS) in infants that required pharmacological treatment for NAS." | 8.12 | Is Maternal Methadone Dose Associated with the Severity of Neonatal Abstinence Syndrome? ( Adeniyi-Jones, S; Aghai, ZH; Boelig, RC; Carola, D; Greenspan, JS; Kraft, WK; Lafferty, M; Smith, J, 2022) |
| "This pilot study evaluated the relationship between maternal and neonatal R- and S-methadone and R- and S-2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) exposure and the severity of neonatal abstinence syndrome (NAS)." | 8.02 | Stereoselective Analysis of Methadone and EDDP in Laboring Women and Neonates in Plasma and Dried Blood Spots and Association with Neonatal Abstinence Syndrome. ( Evrard, CA; Haas, DM; Haneline, LS; Jones, DR; Masters, AR; Metzger, IF; Quinney, SK; Thomas, AE, 2021) |
| "The mainstay of the management of opioid use disorder in pregnancy is with methadone or buprenorphine medication-assisted treatment." | 7.96 | Use of naltrexone in treating opioid use disorder in pregnancy. ( Katz, E; Towers, CV; Visconti, K; Weitz, B, 2020) |
| "To assess safety and effectiveness of transitioning from methadone to buprenorphine when necessary during pregnancy." | 7.88 | Transitioning from methadone to buprenorphine maintenance in management of opioid use disorder during pregnancy. ( Johnson, S; Martin, PR, 2018) |
| "Antenatal exposure to methadone or buprenorphine often causes neonatal abstinence syndrome (NAS) in newborns." | 7.88 | Antenatal methadone vs buprenorphine exposure and length of hospital stay in infants admitted to the intensive care unit with neonatal abstinence syndrome. ( Benjamin, DK; Bennett, MM; Clark, RH; Miller, ES; Murthy, K; Smith, PB; Tolia, VN, 2018) |
| "Our objective was to estimate the association between methadone and neonatal abstinence syndrome compared with buprenorphine using a probabilistic bias analysis to account for unmeasured confounding by severity of addiction." | 7.88 | Methadone Versus Buprenorphine for Opioid Use Dependence and Risk of Neonatal Abstinence Syndrome. ( Bodnar, LM; Caritis, SN; Lemon, LS; Platt, RW; Venkataramanan, R, 2018) |
| " Factors influencing adherence to buprenorphine during pregnancy have not been identified." | 7.88 | Buprenorphine medication-assisted treatment during pregnancy: An exploratory factor analysis associated with adherence. ( Catlin, D; Coker, JL; Knight, B; Ray-Griffith, S; Stowe, ZN, 2018) |
| "To compare neonatal abstinence syndrome prevalence and characteristics among neonates born to women prescribed buprenorphine and naloxone compared with methadone during pregnancy." | 7.81 | Buprenorphine and naloxone compared with methadone treatment in pregnancy. ( Jones, H; Seashore, C; Stringer, EM; Stuebe, AM; Thorp, J; Wiegand, SL, 2015) |
| "This article aims to describe neonatal outcomes, clinical correlates, and the rate for neonatal abstinence syndrome (NAS) for women on methadone maintenance therapy." | 7.81 | Maternal methadone treatment and neonatal abstinence syndrome. ( Faisal, M; Li, S; Liu, WF; Singh, K, 2015) |
| " The birth weights of methadone-exposed neonates of the women who tapered more than 50% were significantly higher than for the methadone-exposed neonates of the women tapering between 11 and 50%." | 7.81 | Tapering from Methadone or Buprenorphine during Pregnancy: Maternal and Neonatal Outcomes in Norway 1996-2009. ( Bakstad, B; Bjarkø, L; Ravndal, E; Skurtveit, S; Tanum, L; Waal, H; Welle-Strand, GK, 2015) |
| "To identify and describe infant deaths presenting suddenly and unexpectedly in whom there was a history of maternal methadone consumption or misuse of drugs during pregnancy." | 7.81 | Maternal use of methadone and risk of sudden neonatal death. ( Cohen, MC; Coombs, RC; Morley, SR, 2015) |
| "To evaluate neonatal abstinence syndrome (NAS) treatment outcomes achieved using an optimized methadone weaning protocol developed using pharmacokinetic (PK) modeling compared with standard methadone weaning." | 7.81 | Cohort Analysis of a Pharmacokinetic-Modeled Methadone Weaning Optimization for Neonatal Abstinence Syndrome. ( Hall, ES; Meinzen-Derr, J; Wexelblatt, SL, 2015) |
| "The primary objective was to determine whether oral morphine sulfate contributed to decreased length of stay, both in the hospital and neonatal intensive care unit (NICU), when compared to oral methadone for the treatment of neonatal abstinence syndrome (NAS)." | 7.81 | Retrospective chart review comparing morphine and methadone in neonates treated for neonatal abstinence syndrome. ( Hager, SJ; Spurlock, D; Young, ME, 2015) |
| "To evaluate the effectiveness of methadone for the treatment of neonatal abstinence syndrome when used according to a preexisting clinical pathway." | 7.80 | Effectiveness of a clinical pathway with methadone treatment protocol for treatment of neonatal abstinence syndrome following in utero drug exposure to substances of abuse*. ( Bhatt-Mehta, V; Ng, CM; Schumacher, RE, 2014) |
| "This report, the first description of Italian cases of nystagmus related to use of methadone during pregnancy, underlies the importance of a careful investigation of drug use in pregnancy in cases of unexplained congenital nystagmus." | 7.79 | Congenital nystagmus in two infants born from mothers exposed to methadone during pregnancy. ( Battini, R; Cioni, G; Gamucci, A; Tinelli, F, 2013) |
| "In a tertiary neonatal care center in Taiwan, three neonates whose mothers self-reported heroin abuse with methadone treatment during pregnancy were studied." | 7.78 | Perinatal effects of combined use of heroin, methadone, and amphetamine during pregnancy and quantitative measurement of metabolites in hair. ( Chang, YZ; Chen, JY; Chen, SC; Ng, YY; Su, PH; Yang, C, 2012) |
| "To identify maternal and neonatal factors that impact response to methadone therapy for neonatal abstinence syndrome." | 7.77 | Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome. ( Akinbi, H; Isemann, B; Meinzen-Derr, J, 2011) |
| "Determine whether infants exposed to chronic maternal methadone with abnormal intrapartum fetal heart rate (FHR) patterns are more likely to require treatment for neonatal abstinence syndrome (NAS)." | 7.77 | Association between intrapartum fetal heart rate patterns and neonatal abstinence syndrome in methadone exposed neonates. ( Albright, B; Brown, SA; Hsi, A; Leeman, LM; Rayburn, WF; Skipper, B, 2011) |
| "05), birth weight, and neonatal morbidities were similar regardless of the maternal methadone dose." | 7.77 | Higher maternal doses of methadone does not increase neonatal abstinence syndrome. ( Bombrys, A; Grier, M; Habli, M; Livingston, J; Pizarro, D; Sibai, B, 2011) |
| "The aim of this study is to better understand anticipated changes in daily methadone doses as a guide for prescription during pregnancy." | 7.77 | Changes in methadone maintenance therapy during and after pregnancy. ( Abbott, P; Albright, B; de la Torre, L; Price, S; Rayburn, W; Skipper, B, 2011) |
| "This study suggests that a treatment of neonatal abstinence syndrome with clonidine in omission of opiates is possible without causing short-term adverse cardiovascular effects." | 7.76 | Treatment of neonatal abstinence syndrome with clonidine and chloral hydrate. ( Bastanier, C; Beske, F; Esmaeili, A; Keinhorst, AK; Schlösser, R; Schuster, T, 2010) |
| "Infants born to drug-misusing mothers prescribed methadone in pregnancy are at risk of a range of visual problems, the underlying causes of which are not clear." | 7.76 | Ophthalmic, clinical and visual electrophysiological findings in children born to mothers prescribed substitute methadone in pregnancy. ( Bradnam, MS; Hamilton, R; MacKinnon, JR; Mactier, H; McGlone, L; Russell, HC, 2010) |
| "To estimate the relationship between maternal methadone dose and the incidence of neonatal abstinence syndrome (NAS)." | 7.76 | Relationship between maternal methadone dose at delivery and neonatal abstinence syndrome. ( Almario, CV; Baxter, JK; Berghella, V; Dysart, KC; Hayes, EJ; Seligman, NS, 2010) |
| "Methadone is standard pharmacotherapy for opioid-dependent pregnant women, yet the relationship between maternal methadone dose and neonatal abstinence syndrome (NAS) severity is still unclear." | 7.76 | Prenatal methadone exposure, meconium biomarker concentrations and neonatal abstinence syndrome. ( Choo, RE; Concheiro, M; Elko, A; Gray, TR; Huestis, MA; Jansson, LM; Jones, HE; Williams, E, 2010) |
| " This study aims to determine the infant mortality rate of infants born to women on a methadone program during pregnancy and to identify any modifiable risk factors." | 7.76 | Infant mortality among women on a methadone program during pregnancy. ( Burns, L; Conroy, E; Mattick, RP, 2010) |
| " This study compared the acoustic cry characteristics of infants born to mothers maintained on methadone during pregnancy with those of infants not exposed to methadone during pregnancy." | 7.75 | Acoustic cry characteristics of infants exposed to methadone during pregnancy. ( Quick, ZL; Robb, MP; Woodward, LJ, 2009) |
| "The purpose of this study was to examine high-dose methadone in pregnant women and its effect on the duration of neonatal abstinence syndrome." | 7.75 | High-dose methadone in pregnant women and its effect on duration of neonatal abstinence syndrome. ( Cordero, L; Gardner, DK; Lim, S; Prasad, MR; Samuels, P, 2009) |
| "Four hundred and fifty singleton pregnancies of drug-misusing women prescribed substitute methadone in pregnancy." | 7.75 | Maternal methadone use in pregnancy: factors associated with the development of neonatal abstinence syndrome and implications for healthcare resources. ( Dryden, C; Hepburn, M; Mactier, H; Young, D, 2009) |
| "Empirical evidence is needed to guide adequate postpartum pain relief of methadone and buprenorphine stabilized patients." | 7.75 | Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy. ( Dahne, J; Johnson, R; Jones, HE; Lemoine, L; Milio, L; O'Grady, K; Ordean, A; Selby, P, 2009) |
| "Prior studies noted elevated preterm birth (PTB) rates among opiate-addicted women treated with methadone." | 7.75 | Risk factors for preterm birth among opiate-addicted gravid women in a methadone treatment program. ( Almario, CV; Baxter, JK; Berghella, V; Dysart, KC; Seligman, NS, 2009) |
| "To describe the patterns of screening for hepatitis C virus (HCV) infection in methadone-maintained pregnant women and their infants." | 7.75 | Screening for hepatitis C virus infection in methadone-maintained mothers and their infants. ( An, EI; Leroi, MJ; Liu, AJ; Murray, HG; Nanan, RK; Tetstall, E, 2009) |
| "Methadone-maintained pregnant patients with mood disorders have compromised treatment outcomes ( [1] )." | 7.75 | The impact of mood disorders on the delivery and neonatal outcomes of methadone-maintained pregnant patients. ( Chisolm, MS; Fitzsimons, H; Heil, SH; Jones, HE; O'Grady, KE; Tuten, M, 2009) |
| "To examine the association between retention in methadone treatment during pregnancy and key neonatal outcomes." | 7.74 | Methadone in pregnancy: treatment retention and neonatal outcomes. ( Burns, L; Lim, K; Mattick, RP; Wallace, C, 2007) |
| "We determined the effect of preterm delivery on the course of neonatal abstinence syndrome (NAS) in infants born to mothers participating in a methadone maintenance program." | 7.74 | Sequela of preterm versus term infants born to mothers on a methadone maintenance program: differential course of neonatal abstinence syndrome. ( Dysart, K; Greenspan, JS; Hsieh, HC; Kaltenbach, K, 2007) |
| "Sixty-eight patients treated with methadone for opiate dependence during pregnancy (vaginal n=35; cesarean n=33) were matched retrospectively to control women." | 7.74 | Intrapartum and postpartum analgesia for women maintained on methadone during pregnancy. ( Benvenuto, A; Howard, D; Meyer, M; Plante, D; Wagner, K, 2007) |
| "Data from this non-randomized comparison suggest that buprenorphine may offer advantages for treatment of opiate dependence during pregnancy." | 7.74 | Buprenorphine and methadone treatment of opiate dependence during pregnancy: comparison of fetal growth and neonatal outcomes in two consecutive case series. ( Heilig, M; Kakko, J; Sarman, I, 2008) |
| "The aim of the study was to analyze the neonatal impact of a methadone maintenance program in pregnancy, and the social resources of the families involved." | 7.73 | Methadone maintenance program in pregnancy in a Swiss perinatal center (II): neonatal outcome and social resources. ( Arlettaz, R; Bucher, HU; Das-Kundu, S; Fauchère, JC; Kashiwagi, M; Lang, A, 2005) |
| "This study assesses the effect of higher doses of methadone during pregnancy on maternal and fetal outcomes." | 7.73 | High-dose methadone maintenance in pregnancy: maternal and neonatal outcomes. ( Anania, B; Leamon, MH; McCarthy, JJ; Parr, MS, 2005) |
| "Measurement of plasma methadone concentration to investigate the rate of clearance of methadone prescribed for heroin dependence in the first, second and third trimesters of pregnancy." | 7.73 | Changes to methadone clearance during pregnancy. ( Boys, A; Hay, A; Raistrick, D; Rostami-Hodjegan, A; Wolff, K, 2005) |
| "To assess the outcomes of infants born to mothers receiving methadone for the management of pain in pregnancy." | 7.72 | Outcomes of infants born to mothers receiving methadone for pain management in pregnancy. ( Kuschel, C; Sharpe, C, 2004) |
| "To assess the usefulness of cord and serum methadone concentrations at 2 days of age in predicting the severity of neonatal abstinence syndrome (NAS) in infants whose mothers received methadone during pregnancy." | 7.72 | Can methadone concentrations predict the severity of withdrawal in infants at risk of neonatal abstinence syndrome? ( Austerberry, L; Cornwell, M; Couch, R; Kuschel, CA; Rowley, RS, 2004) |
| "The purpose of this study is to evaluate women receiving methadone maintenance during pregnancy." | 7.70 | Methadone maintenance in pregnancy: a reappraisal. ( Britton, KA; Brizendine, E; Brown, HL; Hiett, AK; Mahaffey, D; Turnquest, MA, 1998) |
| "The volume of feeds, changes in infant body weight, as well as occurrence of adverse clinical effects in infants withdrawing from methadone were studied during the first month of life." | 7.70 | Hyperphagia in neonates withdrawing from methadone. ( Kastner, B; Martinez, A; Taeusch, HW, 1999) |
| "The authors describe their experience with methadone treatment in pregnancy." | 7.67 | Methadone in pregnancy: clinical-toxicological aspects. ( Chiarotti, M; De Giovanni, N; Falasconi, AM; Offidani, C, 1986) |
| " These two groups were compared with a group of women who had used narcotics in the past and were maintained on methadone during pregnancy, and with a group of drug-free women." | 7.67 | Cocaine use in pregnancy. ( Burns, KA; Burns, WJ; Chasnoff, IJ; Schnoll, SH, 1985) |
| "Body weight gain and food and water consumption of female rats receiving daily methadone injections (5 mg/kg) intraperitoneally prior to mating and during gestation and lactation were studied." | 7.66 | Effects of chronic methadone treatment on maternal body weight and food and water consumption in rats. ( McLaughlin, PJ; White, WJ; Zagon, IS, 1978) |
| "The course of pregnancy and delivery in 28 women under closely supervised methadone maintenance (group 1) was compared with that of 57 women using heroin or methadone under less controlled circumstances (group 2) and with that of 30 women free of mood-altering medications (group 3)." | 7.65 | Narcotic dependency in pregnancy. Methadone maintenance compared to use of street drugs. ( Adamsons, K; Stimmel, B, 1976) |
| "A retrospective, inception cohort, nonrandomized control design was employed to evaluate the effects of daily vs twice daily dosing of methadone on opiate/cocaine use, and noncompliance with urine toxicology requests in methadone-maintained pregnant women, n = 45." | 6.68 | Methadone dosing and pregnancy: impact on program compliance. ( DePetrillo, PB; Rice, JM, 1995) |
| " These recommendations address: antepartum issues including treatment, dosage and pharmacological considerations, medical conditions and lab tests, intrapartum issues, postpartum concerns including breastfeeding, neonatal withdrawal, and developmental effects associated with methadone." | 6.41 | Clinical management of methadone dependence during pregnancy. ( Curet, LB; Dorato, V; Wallerstedt, C; Wilbourne, P, 2001) |
| "For methadone, 11 cases were positive in hair, 9 in meconium and 6 in placenta and umbilical cord." | 5.46 | Bioanalysis for cocaine, opiates, methadone, and amphetamines exposure detection during pregnancy. ( Concheiro, M; Concheiro-Guisan, A; Cruz-Landeira, A; de Castro, A; Gónzalez-Colmenero, E; Lendoiro, E; López-Rivadulla, M; Macias-Cortiña, M; Peñas-Silva, P, 2017) |
| "Methadone use for the management of opioid dependency during pregnancy is commonplace." | 5.41 | Precision dosing of methadone during pregnancy: A pharmacokinetics virtual clinical trials study. ( Badhan, RKS; Gittins, R, 2021) |
| "Weight loss was less in small for gestational age compared to appropriately grown infants (p<0." | 5.38 | Postnatal weight loss in substitute methadone-exposed infants: implications for the management of breast feeding. ( Campbell, N; Dryden, C; Mactier, H; Young, D, 2012) |
| "Methadone maintenance treatment (MMT) is the standard treatment of choice for pregnant opiate addicts; however, data on newborn outcomes are contradictory." | 5.38 | Duration of methadone maintenance treatment during pregnancy and pregnancy outcome parameters in women with opiate addiction. ( Adelson, M; Bloch, M; Dollberg, S; Peles, E; Schreiber, S, 2012) |
| "Pregnancy care for these women needs to continue to develop to improve overall outcomes." | 5.38 | Maternal and neonatal outcomes following methadone substitution during pregnancy. ( Ash, A; Douiri, A; Greig, E, 2012) |
| " Maternal opiate dosing has been investigated with conflicting results." | 5.36 | Perinatal risk factors for the neonatal abstinence syndrome in infants born to women on methadone maintenance therapy. ( Cook, CM; Jones, MP; Liu, AJ; Murray, H; Nanan, R, 2010) |
| " Furthermore, late-gestation mice experienced significant increases in the [(3)H]saquinavir and [(3)H]methadone brain-to-plasma ratios 60 min after dosing relative to mid-gestation (p < 0." | 5.35 | Distribution of saquinavir, methadone, and buprenorphine in maternal brain, placenta, and fetus during two different gestational stages of pregnancy in mice. ( Coles, LD; Eddington, ND; Hassan, HE; Lee, IJ, 2009) |
| "Methadone levels were kept blinded from clinicians." | 5.31 | Methadone trough levels in pregnancy. ( Berghella, V; Drozdick, J; Hill, M; Kaltenbach, K, 2002) |
| "Traditionally, methadone maintenance therapy has been a once-daily dosing schedule." | 5.30 | Alterations in methadone metabolism during late pregnancy. ( Jarvis, MA; Kniseley, JS; Schnoll, SH; Wu-Pong, S, 1999) |
| " Methadone plasma concentration-time data were fit to a one-compartment pharmacokinetic model by extended least-squares regression." | 5.28 | Altered methadone pharmacokinetics in pregnancy: implications for dosing. ( Camara, P; DePetrillo, P; Dudley, M; Griffiths, W; Swift, RM, 1989) |
| "Newborns who are prenatally exposed to methadone are at risk for neonatal abstinence syndrome and the associated excess weight loss and poor weight gain." | 5.27 | Randomized Clinical Trial of Standard- Versus High-Calorie Formula for Methadone-Exposed Infants: A Feasibility Study. ( Baker, R; Bogen, DL; Cohlan, B; Hanusa, BH; Medoff-Cooper, B, 2018) |
| "Methadone and buprenorphine are recommended to treat opioid use disorders during pregnancy." | 5.27 | Prenatal exposure to methadone or buprenorphine: Early childhood developmental outcomes. ( Coyle, MG; Fischer, G; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; O'Grady, KE; Salisbury, AL; Stine, S, 2018) |
| " While methadone-maintenance currently is the standard of care for opioid dependence during pregnancy, research suggests that buprenorphine-maintenance may be associated with shorter infant hospital lengths of stay (LOS) relative to methadone-maintenance." | 5.19 | Design considerations for point-of-care clinical trials comparing methadone and buprenorphine treatment for opioid dependence in pregnancy and for neonatal abstinence syndrome. ( Hall, ES; Lewis, D; Marcotte, M; Theobald, J; Van Hook, J; Wexelblatt, SL; Wilder, C; Winhusen, T, 2014) |
| "Induction onto buprenorphine during pregnancy may be more challenging than induction onto methadone." | 5.17 | Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention. ( Coyle, MG; Fischer, G; Heil, SH; Holbrook, AM; Jones, HE; Kaltenbach, K; Martin, PR; Stine, SM, 2013) |
| " The objective of this study is to examine the extent to which cigarette smoking profiles differentially changed during the course of pregnancy in opioid-dependent patients receiving either double-blind methadone or buprenorphine." | 5.17 | A comparison of cigarette smoking profiles in opioid-dependent pregnant patients receiving methadone or buprenorphine. ( Acquavita, SP; Chisolm, MS; Fitzsimons, H; Heil, SH; Jansson, LM; Jones, HE; Kaltenbach, K; Leoutsakos, JM; Martin, PR; Tuten, M; Wilson-Murphy, M; Winklbaur, B, 2013) |
| "To identify factors that predict the expression of neonatal abstinence syndrome (NAS) in infants exposed to methadone or buprenorphine in utero." | 5.16 | Predicting treatment for neonatal abstinence syndrome in infants born to women maintained on opioid agonist medication. ( Coyle, MG; Heil, SH; Holbrook, AM; Jones, HE; Kaltenbach, K; Martin, PR; Salisbury, AL; Stine, SM, 2012) |
| "To compare the profile of signs of neonatal abstinence syndrome (NAS) in methadone- versus buprenorphine-exposed infants." | 5.16 | Differences in the profile of neonatal abstinence syndrome signs in methadone- versus buprenorphine-exposed neonates. ( Arria, AM; Badger, GJ; Coyle, MG; Gaalema, DE; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; Scott, TL; Stine, SM, 2012) |
| "Buprenorphine appears to have an acceptable safety profile for use during pregnancy." | 5.16 | Infections and obstetric outcomes in opioid-dependent pregnant women maintained on methadone or buprenorphine. ( Baxter, JK; Coyle, MG; Heil, SH; Holbrook, AM; Jones, HE; Kaltenbach, K; Martin, PR; Stine, SM, 2012) |
| "To examine hepatic enzyme test results throughout the course of pregnancy in women maintained on methadone or buprenorphine." | 5.16 | Effect of hepatitis C virus status on liver enzymes in opioid-dependent pregnant women maintained on opioid-agonist medication. ( Coyle, MG; Heil, SH; Holbrook, AM; Jones, HE; Kaltenbach, K; Martin, PR; McNicholas, LF; O'Grady, KE; Stine, SM, 2012) |
| " Methadone maintenance yielded to a significantly higher neonatal birth weight." | 5.15 | Randomized controlled trials in pregnancy: scientific and ethical aspects. Exposure to different opioid medications during pregnancy in an intra-individual comparison. ( Arria, A; Aschauer, C; Bäwert, A; Fischer, G; Jagsch, R; Jones, H; Leitich, H; Rohrmeister, K; Unger, A; Winklbaur, B, 2011) |
| "In order to investigate the effects of exposure to buprenorphine compared with methadone during pregnancy, a prospective multicenter study was conducted in collaboration with maternity hospitals, maintenance therapy centers, and general practitioners involved in addiction care." | 5.15 | Buprenorphine versus methadone in pregnant opioid-dependent women: a prospective multicenter study. ( Berrebi, A; Chaumerliac, C; Damase-Michel, C; Garipuy, D; Hammou, Y; Lacroix, I; Lapeyre-Mestre, M; Montastruc, JL; Schmitt, L, 2011) |
| "One hundred and fourteen subjects were included in the analysis, with 77 in SP (n = 51 methadone, n = 26 buprenorphine), and 37 in CT (n = 19 methadone, n = 18 buprenorphine), comparing maternal concomitant consumption during third trimester, demographic birth data, duration of treatment for neonatal abstinence syndrome (NAS), morphine dose for NAS treatment and length of hospital stay (LOS)." | 5.15 | Impact of treatment approach on maternal and neonatal outcome in pregnant opioid-maintained women. ( Aschauer, C; Ebner, N; Fischer, G; Jagsch, R; Metz, V; Pribasnig, A; Würzl, J, 2011) |
| "This was a secondary analysis of data collected in a prospective randomized, double-blind, double-dummy, multicenter trial (MOTHER study) that examined the comparative safety and efficacy of methadone and buprenorphine during pregnancy." | 5.15 | Are male neonates more vulnerable to neonatal abstinence syndrome than female neonates? ( Bäwert, A; Coyle, M; Fischer, G; Jagsch, R; Martin, PR; Rohrmeister, K; Unger, A; Winklbaur, B, 2011) |
| "Daily methadone maintenance is the standard of care for opiate dependency during pregnancy." | 5.14 | Maternal methadone dosing schedule and fetal neurobehaviour. ( Dipietro, JA; Elko, A; Jansson, LM; Kivlighan, KT; Knauer, H; Velez, M, 2009) |
| "Methadone, a full mu-opioid agonist, is the recommended treatment for opioid dependence during pregnancy." | 5.14 | Neonatal abstinence syndrome after methadone or buprenorphine exposure. ( Arria, AM; Coyle, MG; Fischer, G; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; O'Grady, KE; Selby, P; Stine, SM, 2010) |
| " Infants born to buprenorphine maintained women are not exposed to a greater proportion of the maternal dose compared with methadone and may be exposed to relatively less of the maternal dose compared with infants born to women maintained on methadone during pregnancy." | 5.14 | (R)- and (S)-methadone and buprenorphine concentration ratios in maternal and umbilical cord plasma following chronic maintenance dosing in pregnancy. ( Foster, DJ; Gordon, AL; Lopatko, OV; Somogyi, AA; White, JM, 2010) |
| " Free and total buprenorphine and norbuprenorphine, nicotine, opiates, cocaine, benzodiazepines, and metabolites were quantified in meconium from 10 infants born to women who had received buprenorphine during pregnancy." | 5.13 | Correlations of maternal buprenorphine dose, buprenorphine, and metabolite concentrations in meconium with neonatal outcomes. ( Choo, RE; Huestis, MA; Johnson, RE; Jones, HE; Kacinko, SL, 2008) |
| "The aim of the study was to evaluate the effect of substitution therapy in heroin addicted pregnant women on the course of pregnancy, perinatal outcomes and course of the neonatal abstinence syndrome." | 5.13 | Prospective randomised comparative study of the effect of buprenorphine, methadone and heroin on the course of pregnancy, birthweight of newborns, early postpartum adaptation and course of the neonatal abstinence syndrome (NAS) in women followed up in the ( Binder, T; Vavrinková, B, 2008) |
| "Eighteen women were assigned randomly to receive either methadone (n = 9) or buprenorphine (n = 9) during weeks 24-29 of pregnancy." | 5.12 | Methadone versus buprenorphine in pregnant addicts: a double-blind, double-dummy comparison study. ( Aschauer, H; Baewert, A; Fischer, G; Jagsch, R; Langer, M; Ortner, R; Rohrmeister, K, 2006) |
| " The mothers received methadone (n=22), slow-release oral morphine (n=17) or buprenorphine (n=14) throughout pregnancy." | 5.12 | Management of neonatal abstinence syndrome in neonates born to opioid maintained women. ( Baewert, A; Ebner, N; Fischer, G; Jagsch, R; Peternell, A; Rohrmeister, K; Thau, K; Winklbaur, B, 2007) |
| "Though methadone pharmacotherapy is the treatment of choice for opiate-dependence during pregnancy in the USA, most methadone-exposed neonates develop neonatal abstinence syndrome (NAS)." | 5.12 | Maternal vagal tone change in response to methadone is associated with neonatal abstinence syndrome severity in exposed neonates. ( Dipietro, JA; Elko, A; Jansson, LM; Velez, M, 2007) |
| "Treating opioid-addicted women with methadone in pregnancy increased the number of newborns suffering from neonatal abstinence syndrome (NAS)." | 5.11 | Therapy of the neonatal abstinence syndrome with tincture of opium or morphine drops. ( Birkenfeld, L; Hellmich, M; Herkenrath, P; Langenfeld, S; Müller, C; Theisohn, M, 2005) |
| "This study was designed to compare the neonatal abstinence syndrome (NAS) in neonates of methadone and buprenorphine maintained pregnant opioid-dependent women and to provide preliminary safety and efficacy data for a larger multi-center trial." | 5.11 | Buprenorphine versus methadone in the treatment of pregnant opioid-dependent patients: effects on the neonatal abstinence syndrome. ( Chisholm, CA; Choo, RE; Crocetti, M; Dudas, R; Harrow, C; Huestis, MA; Jansson, LM; Jasinski, DR; Johnson, RE; Jones, HE; Lantz, M; Lester, BM; Milio, L; O'Grady, KE, 2005) |
| "To investigate whether the neonatal abstinence syndrome (NAS) is different in children born to women maintained on slow-release morphine, compared with those maintained on methadone, and to compare additional drug consumption in these groups of women." | 5.09 | Comparison of methadone and slow-release morphine maintenance in pregnant addicts. ( Aschauer, HN; Eder, H; Etzersdorfer, P; Fischer, G; Gombas, W; Jagsch, R; Schatten, C; Schmidl-Mohl, K; Weninger, M, 1999) |
| "A literature search was conducted using scientific databases (PubMed, Scopus, Web of Science, and reports from international institutions) to review published articles on buprenorphine and methadone monitoring during pregnancy." | 5.05 | Monitoring Prenatal Exposure to Buprenorphine and Methadone. ( Busardò, FP; Carlier, J; Di Trana, A; Huestis, MA; La Maida, N; Pichini, S; Tittarelli, R, 2020) |
| "To systematically review and meta-analyse studies of neurodevelopmental outcome of children born to mothers prescribed methadone in pregnancy." | 5.01 | Childhood neurodevelopment after prescription of maintenance methadone for opioid dependency in pregnancy: a systematic review and meta-analysis. ( Boardman, JP; Chappell, FM; Hamilton, R; Mactier, H; Monnelly, VJ, 2019) |
| "To compare the effects of morphine and methadone on length of hospital stay (LOS) or treatment (LOT) and adverse effects in infants with neonatal abstinence syndrome (NAS)." | 4.98 | Morphine and Methadone for Neonatal Abstinence Syndrome: A Systematic Review. ( Gregory, PJ; Hein, DJ; Risoldi Cochrane, Z; Slowiczek, L, 2018) |
| "This study examined the obstetric health of opioid-dependent women who were treated with implant naltrexone during pregnancy, and compared them with women treated with methadone and/or buprenorphine and a cohort of non-opioid-dependent controls." | 4.95 | A Retrospective Cohort Study of Obstetric Outcomes in Opioid-Dependent Women Treated with Implant Naltrexone, Oral Methadone or Sublingual Buprenorphine, and Non-Dependent Controls. ( Hulse, G; Kelty, E, 2017) |
| "A literature search of PubMed (1966 to March 2016) and EMBASE (1973 to March 2016) was completed using the search terms buprenorphine, methadone, pregnancy, opioid, and neonatal abstinence syndrome Priority was given to randomized controlled trials and trials directly comparing buprenorphine and methadone during pregnancy." | 4.93 | Buprenorphine Versus Methadone for Opioid Dependence in Pregnancy. ( Campbell, K; Crannage, E; Forinash, A; Noormohammadi, A; Shyken, J; Yancey, A, 2016) |
| "Moderately strong evidence indicates lower risk of preterm birth, greater birth weight and larger head circumference with buprenorphine treatment of maternal opioid use disorder during pregnancy compared with methadone treatment, and no greater harms." | 4.93 | Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child. ( Amick, HR; Jones, HE; Joyce, AR; Kim, MM; Mann, AL; Murrelle, EL; Zedler, BK, 2016) |
| "Parents of infants with neonatal abstinence syndrome (NAS) in the NICU may have questions about the long-term consequences of prenatal exposure to methadone, both asked and unasked." | 4.93 | Long-Term Outcomes of Infants with Neonatal Abstinence Syndrome. ( Armstrong, K; Brooks, SS; Clark, L; Cline, GJ; Germain, AM; Maguire, DJ; Shaffer-Hudkins, E; Taylor, S, 2016) |
| " This review summarizes existing knowledge about smoking cessation treatments for pregnant women on buprenorphine or methadone, the two forms of medication-assisted treatment for opioid use disorder indicated for prenatal use." | 4.91 | Treating tobacco use disorder in pregnant women in medication-assisted treatment for an opioid use disorder: a systematic review. ( Akerman, SC; Blunt, HB; Brunette, MF; Goodman, DJ; Green, AI; Heil, SH, 2015) |
| "Buprenorphine and methadone are opioid-receptor agonists used as opioid substitution therapy during pregnancy to limit exposure of the fetus to cycles of opioid withdrawal and reduce the risk of infectious comorbidities of illicit opioid use." | 4.90 | Buprenorphine and methadone for opioid addiction during pregnancy. ( Mozurkewich, EL; Rayburn, WF, 2014) |
| "The present paper considers naltrexone to treat opioid dependence during pregnancy." | 4.89 | Naltrexone in the treatment of opioid-dependent pregnant women: the case for a considered and measured approach to research. ( Chisolm, MS; Jansson, LM; Jones, HE; Terplan, M, 2013) |
| " The standard of care for illicit or prescription opioid dependence during pregnancy is opioid agonist (methadone or buprenorphine) substitution therapy, which are also frequently abused." | 4.89 | Novel pharmacotherapeutic strategies for treatment of opioid-induced neonatal abstinence syndrome. ( Gauda, EB; Jones, CH; Lewis, T; McLemore, GL, 2013) |
| "Many individuals receiving methadone maintenance treatment (MMT) for opioid addiction also require treatment for acute or chronic pain, and the presence of pain is known to have a negative impact on patient health and function." | 4.89 | Chronic and acute pain and pain management for patients in methadone maintenance treatment. ( Eyler, EC, 2013) |
| " However, concerns about neonatal abstinence syndrome (NAS) in methadone-exposed neonates have resulted in efforts to withdraw women from methadone during pregnancy or to use buprenorphine, a mixed agonist/antagonist opiate in place of methadone." | 4.88 | Intrauterine abstinence syndrome (IAS) during buprenorphine inductions and methadone tapers: can we assure the safety of the fetus? ( McCarthy, JJ, 2012) |
| "This article provides an overview and discussion of the collective maternal, fetal and neonatal outcome research on women maintained on methadone or buprenorphine during pregnancy." | 4.88 | Methadone and buprenorphine for the management of opioid dependence in pregnancy. ( Finnegan, LP; Jones, HE; Kaltenbach, K, 2012) |
| "While buprenorphine produces a less severe neonatal abstinence syndrome than methadone, both methadone and buprenorphine are important parts of a complete comprehensive treatment approach for opioid-dependent pregnant women." | 4.88 | Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review. ( Arria, AM; Baewert, A; Coyle, MG; Fischer, G; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; Selby, P; Stine, SM, 2012) |
| "After completing this CME activity, physicians should be better able to assess the treatment options available to patients with opioid addiction during pregnancy, compare the risk/safety profiles of methadone and buprenorphine, and evaluate the recommendations and current data surrounding breast-feeding while on opioid maintenance treatment." | 4.88 | Opioid addiction in pregnancy. ( Lee-Parritz, A; Saia, K; Shainker, SA, 2012) |
| "This manuscript provides an overview of the current scientific literature on the impact of maternal drug use, specifically opioids and cocaine, during pregnancy on the acute and long-term outcomes of infants and toddlers from birth through age 3 years." | 4.86 | Prenatal drug exposure: infant and toddler outcomes. ( Accornero, VH; Bandstra, ES; Mansoor, E; Morrow, CE, 2010) |
| "To determine if there is a relationship between maternal methadone dose in pregnancy and the diagnosis or medical treatment of neonatal abstinence syndrome (NAS)." | 4.86 | Methadone dose and neonatal abstinence syndrome-systematic review and meta-analysis. ( Clarke, M; Cleary, BJ; Donnelly, J; Fahey, T; Gallagher, PJ; Murphy, DJ; Strawbridge, J, 2010) |
| " Examples of situations that characterise these special populations are: co-infection with hepatitis virus B and/or C, pregnancy, lipodystrophy, cardiovascular risk, renal failure, treatment of children and adolescents, immigrant health care, and the management of patients receiving methadone replacement therapy, among others." | 4.84 | [Utility of atazanavir in special populations]. ( Antela López, A, 2008) |
| "Methadone is a synthetic opioid that is effective for the relief of moderate-to-severe pain and for the treatment of opioid dependence." | 4.82 | Pharmacokinetics of methadone. ( Kern, SE; Lugo, RA; Satterfield, KL, 2005) |
| " First, women who continued to use illicit heroin throughout pregnancy; secondly, women stabilized on methadone at the time of conception or shortly after and thirdly, women who use heroin well into pregnancy with late entry into methadone treatment, or who continued to use illicit heroin during pregnancy while receiving methadone." | 4.80 | Assessing the relationship between maternal opiate use and neonatal mortality. ( English, DR; Holman, CD; Hulse, GK; Milne, E, 1998) |
| "In the twenty years since the first case of neonatal drug addiction (resulting from the mother's use during pregnancy of morphine, heroin, methadone, cocaine) was referred to our attention, there has been a steady increase in the number of cases per year." | 4.80 | Neonatal drug addiction. ( Fabris, C; Perathoner, C; Prandi, G; Soldi, A, 1998) |
| "Methadone treatment during pregnancy offers overwhelming advantages compared with the less acceptable option of medical detoxification or the unacceptably dangerous option of leaving heroin-addicted women dependent on street drugs." | 4.80 | The methadone-maintained pregnancy. ( Doberczak, TM; Jantunen, M; Kandall, SR; Stein, J, 1999) |
| "Results showed mean reduction in birth weight associated with heroin use: 489 g (95% CI 284-693 g), compared with methadone: 279 g (229-328 g)." | 4.79 | The relationship between maternal use of heroin and methadone and infant birth weight. ( English, DR; Holman, CD; Hulse, GK; Milne, E, 1997) |
| "We compared the association of methadone, buprenorphine, and short-acting opioid exposure with newborn head circumference (HC) and birth weight (BW), and evaluated gestational age (GA) as a mediator." | 4.31 | Association of medication-assisted treatment and short acting opioids with newborn head circumference and birth weight. ( Cox, DF; Craig, AK; Cutler, AJ; Gabrielson, SMB; Picarillo, AP, 2023) |
| " Illicit drug use during the pregnancy was common in all groups, but in the methadone group it was most common (p = 0." | 4.31 | Buprenorphine-naloxone, buprenorphine, and methadone throughout pregnancy in maternal opioid use disorder. ( Kahila, HK; Kanervo, MM; Nikkola, EM; Rantakari, KM; Tupola, SJ, 2023) |
| "Of 400 eligible pregnancies, 85 and 137 individuals received buprenorphine and methadone, respectively, during early pregnancy." | 4.31 | Comparative Safety Analysis of Opioid Agonist Treatment in Pregnant Women with Opioid Use Disorder: A Population-Based Study. ( Brothers, TN; Hartzema, A; Lewkowitz, AK; Meador, KJ; Pawasauskas, J; Quilliam, BJ; Wang, S; Ward, KE; Wen, X, 2023) |
| " In adjusted analyses assessing likelihood of initiation for individual MOUD, pregnancy status was associated with an increase in buprenorphine (adjusted odds ratio [aOR] 1." | 4.31 | Initiation and Treatment Discontinuation of Medications for Opioid Use Disorder in Pregnant People Compared With Nonpregnant People. ( Bierut, LJ; Carter, EB; Grucza, RA; Jones, HE; Kelly, JC; Martin, CE; Schiff, DM; Xu, KY, 2023) |
| " buprenorphine) or pregnancy status." | 4.31 | Treatment access for opioid use disorder among women with medicaid in Florida. ( Elmore, AL; Fryer, K; Marshall, J; McNeer, E; Mehra, S; Patrick, SW; Reid, CN; Salemi, JL; Sappenfield, WM, 2023) |
| " Key indicators for this analysis include pregnancy testing at intake, number of county jails offering methadone or buprenorphine to pregnant incarcerated persons for detoxification on admission, continuation of pre-incarceration treatment, or linkage to post-incarceration treatment." | 4.31 | United States county jail treatment and care of pregnant incarcerated persons with opioid use disorder. ( Beckwith, C; Benck, KN; Jones, AK; Nowotny, KM; Omori, M; Rubinstein, LB; Seide, K, 2023) |
| " Methadone is recommended for the treatment of opioid use disorders during pregnancy, increasing the number of children prenatally exposed to long-acting opioids." | 4.31 | Methadone administered to rat dams during pregnancy and lactation affects the circadian rhythms of their pups. ( Bendová, Z; Novotný, J; Pačesová, D; Spišská, V, 2023) |
| "Methadone is used as a substitute for illicit opioids during pregnancy." | 4.31 | Long-Term Visual and Neurodevelopmental Outcomes in Two Children with Congenital Nystagmus Secondary to Methadone Exposure In utero. ( Accorsi, P; Fazzi, E; Franzoni, A; Galli, J; Loi, E; Micheletti, S; Pansera, L, 2023) |
| " Research consistently demonstrates the efficacy of medications for OUD (MOUD); however, researchers have called for additional studies evaluating the safety of MOUD during pregnancy, particularly the relative safety of two commonly used MOUD medications-methadone and buprenorphine." | 4.12 | A retrospective, observational study on medication for opioid use disorder during pregnancy and risk for neonatal abstinence syndrome. ( Aujla, R; Boyars, L; Cleary, E; Douglas, E; Guille, C; Smith, C; Sujan, A, 2022) |
| "The preterm birth rate among individuals using buprenorphine for opioid use disorder (22." | 4.12 | Risk factors for preterm birth among gravid individuals receiving buprenorphine for opioid use disorder. ( Abdelwahab, M; Cleary, EM; Petrich, M; Rood, KM; Walker, E; Wang, H, 2022) |
| " Four unique themes emerged as barriers to medication utilization and adherence in the perinatal period: 1) Lack of agency and autonomy surrounding medication decisions because pregnancy or parenting status affected treatment adherence; 2) Hesitancy to use MOUD to minimize risk of newborn withdrawal; 3) Concern about increased scrutiny and potential loss of custody due to mandated child protective services reporting for opioid-exposure at delivery in Massachusetts; and 4) Perception that treatment environments, particularly methadone clinics, did not provide gender-responsive or equitable care, and standardized, inflexible visit regulations were particularly difficult to comply with in the early postpartum period." | 4.12 | "You have to take this medication, but then you get punished for taking it:" lack of agency, choice, and fear of medications to treat opioid use disorder across the perinatal period. ( Bernstein, J; Gray, JR; Greenfield, SF; Hoeppner, BB; Jones, HE; Kelly, JF; MacMillan, KDL; Muftu, S; Partridge, S; Schiff, DM; Terplan, M; Wilens, TE; Work, EC, 2022) |
| "Methadone (MTD) is a commonly prescribed treatment for opioid use disorder in pregnancy, despite limited information on the effects of passive exposure on fetal brain development." | 4.12 | Perinatal methadone exposure attenuates myelination and induces oligodendrocyte apoptosis in neonatal rat brain. ( Cai, J; Chu, T; Devlin Phinney, LA; Gibson, JM; Kong, M; Mellen, N; Wethall, AC; Zeng, W, 2022) |
| "The potential long-term developmental effects of prenatal methadone and buprenorphine exposure during pregnancy are still largely unknown." | 4.12 | Verbal and nonverbal memory in school-aged children born to opioid-dependent mothers. ( Konijnenberg, C; Melinder, A, 2022) |
| " Opioid exposure during pregnancy included 16 202 pregnancies exposed to codeine, 4540 to oxycodone, 1244 to tramadol, 260 to methadone (dispensed for pain), 90 to hydromorphone, and 63 to morphine compared with 25 710 exposed to hydrocodone." | 4.12 | Characteristics of Prescription Opioid Analgesics in Pregnancy and Risk of Neonatal Opioid Withdrawal Syndrome in Newborns. ( Bateman, BT; Esposito, DB; Hernández-Díaz, S; Huybrechts, KF; Mogun, H; Straub, L; Werler, MM, 2022) |
| " In early pregnancy, 10,704 pregnant persons were exposed to buprenorphine and 4387 to methadone." | 4.12 | Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy. ( Bateman, BT; Connery, HS; Davis, JM; Gray, KJ; Hernández-Díaz, S; Huybrechts, KF; Jones, HE; Lester, B; Mogun, H; Straub, L; Suarez, EA; Terplan, M, 2022) |
| "To examine the evidence for emerging treatment options, buprenorphine or clonidine, as monotherapy for the treatment of neonatal abstinence syndrome (NAS) against standards of care, morphine or methadone." | 4.12 | Emerging therapies for the treatment of neonatal abstinence syndrome. ( Bobby, LE; Frazier, LM; Gawronski, KM, 2022) |
| "The aim of the study is to assess the correlation between maternal methadone dose and severity of neonatal abstinence syndrome (NAS) in infants that required pharmacological treatment for NAS." | 4.12 | Is Maternal Methadone Dose Associated with the Severity of Neonatal Abstinence Syndrome? ( Adeniyi-Jones, S; Aghai, ZH; Boelig, RC; Carola, D; Greenspan, JS; Kraft, WK; Lafferty, M; Smith, J, 2022) |
| "In our theoretical cohort, treatment of OUD with buprenorphine during pregnancy resulted in 2413 fewer cases of neonatal opioid withdrawal syndrome, 1089 fewer preterm births, 299 fewer cases of fetal growth restriction, 32 fewer stillbirths, and 13 fewer cases of cerebral palsy compared to methadone treatment." | 4.12 | Cost effectiveness of buprenorphine vs. methadone for pregnant people with opioid use disorder. ( Caughey, AB; Hersh, AR; John, C; Robin, AM, 2022) |
| "Given the concerns raised regarding the effects of prenatal exposure to methadone and buprenorphine on the developmental outcomes of the children, this study assessed mental health and use of services in a national sample of school-aged children (N = 78) born to women enrolled in opioid maintenance treatment during pregnancy, compared with a group of foster children (N = 140)." | 4.12 | Mental health and use of health care services in opioid-exposed school-aged children compared to foster children. ( Eikemo, M; Lehmann, S; Muller, AE; Sarfi, M; Welle-Strand, GK, 2022) |
| " Treatment with buprenorphine-naloxone (compared with methadone) reduced odds of each outcome including neonatal abstinence syndrome (adjusted odds ratio: 0." | 4.02 | Opioid Use Disorder and Perinatal Outcomes. ( Homayra, F; Marchand, C; Mead, A; Min, JE; Ng, J; Nosyk, B; Piske, M; Woolner, M; Zhou, H, 2021) |
| "This pilot study evaluated the relationship between maternal and neonatal R- and S-methadone and R- and S-2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) exposure and the severity of neonatal abstinence syndrome (NAS)." | 4.02 | Stereoselective Analysis of Methadone and EDDP in Laboring Women and Neonates in Plasma and Dried Blood Spots and Association with Neonatal Abstinence Syndrome. ( Evrard, CA; Haas, DM; Haneline, LS; Jones, DR; Masters, AR; Metzger, IF; Quinney, SK; Thomas, AE, 2021) |
| "Medications for opioid use disorder, including methadone, combined with comprehensive wraparound services, are the gold standard for treatment in pregnancy." | 4.02 | Racial inequity in methadone dose at delivery in pregnant women with opioid use disorder. ( Abatemarco, DJ; Barber, C; Baxter, JK; Cruz, Y; Hand, DJ; Roman, AR; Rosenthal, EW; Short, VL, 2021) |
| "The number of pregnant women with OUD admitted and treated with methadone, buprenorphine or withdrawal; policies on provision of MOUD and withdrawal in pregnancy." | 3.96 | Opioid use disorder incidence and treatment among incarcerated pregnant women in the United States: results from a national surveillance study. ( Beal, L; Clarke, JG; Latkin, C; Sufrin, C; Sutherland, L; Terplan, M, 2020) |
| "Pregnant smokers recruited to participate in a placebo-controlled trial of bupropion for smoking cessation provided a blood sample for measurement of NMR." | 3.96 | Pregnant Smokers Receiving Opioid Agonist Therapy Have an Elevated Nicotine Metabolite Ratio: A Replication Study. ( Hand, D; Kranzler, HR; Lynch, KG; Oncken, C; Schnoll, R; Tyndale, RF; Washio, Y; Zindel, LR, 2020) |
| " Using imaging, immunofluorescence, multi-electrode array (MEA) and patch clamp recording techniques, we have investigated the effect of methadone, a frequently used opioid during pregnancy, on early neural development, including neuronal growth, neural network activity and synaptic transmission in hCOs." | 3.96 | Methadone interrupts neural growth and function in human cortical organoids. ( Cerf, I; Haddad, GG; Muotri, AR; Negraes, PD; Wang, J; Wu, W; Yao, H; Zhao, HW, 2020) |
| " Furthermore, buprenorphine is associated with milder symptoms of neonatal abstinence syndrome (NAS) compared with methadone." | 3.96 | Prevalence and Geographic Distribution of Obstetrician-Gynecologists Who Treat Medicaid Enrollees and Are Trained to Prescribe Buprenorphine. ( Culhane, J; Meisel, ZF; Nguemeni Tiako, MJ; South, E; Srinivas, SK, 2020) |
| "Methadone is a vital treatment for women with opioid use disorder in pregnancy." | 3.96 | Methadone, Pierre Robin sequence and other congenital anomalies: case-control study. ( Addor, MC; Barisic, I; Cleary, B; de Walle, HEK; Dolk, H; Gatt, M; Klungsoyr, K; Loane, M; Matias Dias, C; McDonnell, B; Neville, A; Pierini, A; Rissmann, A; Tucker, DF; Zurriaga, O, 2020) |
| "The mainstay of the management of opioid use disorder in pregnancy is with methadone or buprenorphine medication-assisted treatment." | 3.96 | Use of naltrexone in treating opioid use disorder in pregnancy. ( Katz, E; Towers, CV; Visconti, K; Weitz, B, 2020) |
| "There is lack of knowledge about the safety of treatment with methadone and buprenorphine as part of opioid maintenance treatment (OMT) during pregnancy." | 3.91 | Prenatal exposure to opioid maintenance treatment and neonatal outcomes: Nationwide registry studies from the Czech Republic and Norway. ( Engeland, A; Gabrhelík, R; Handal, M; Lund, IO; Mravčík, V; Nechanská, B; Skurtveit, S, 2019) |
| "To estimate whether methadone, buprenorphine, or detoxification treatment is the most cost-effective approach to the management of opioid use disorder (OUD) during pregnancy." | 3.91 | Methadone, Buprenorphine, or Detoxification for Management of Perinatal Opioid Use Disorder: A Cost-Effectiveness Analysis. ( Grobman, WA; Miller, ES; Premkumar, A; Terplan, M, 2019) |
| " We present a case report of a neonate born to a 25-year-old mother enrolled in a medication-assisted treatment program for substance use disorder who was noncompliant in prenatal care, using multiple substances throughout the pregnancy, including gabapentin and fentanyl." | 3.91 | Novel Withdrawal Symptoms of a Neonate Prenatally Exposed to a Fentanyl Analog. ( Davies, TH; Hansen, Z; Loudin, S; Murray, S; Nellhaus, EM, 2019) |
| "Using the data linkage between the Methadone Maintenance Treatment (MMT) register with national health insurance, national birth notification system, and birth registration system, we identified 1712 pregnancies with 20 or more gestational weeks from women enrolled in the MMT (heroin-exposed: receiving no methadone treatment during pregnancy, n = 1053 by 882 women; methadone-treated: receiving methadone for at least one day during pregnancy, n = 659 by 574 women) and their 1:10 matched pregnancies from 17,060 women without substance use disorder in the period of 2004-2013." | 3.91 | Inadequate prenatal care utilization among women with and without methadone-treated opioid use disorders in Taiwan. ( Chang, SH; Chen, CY; Fang, SY; Huang, N; Tsay, JH; Wang, IA, 2019) |
| "To assess safety and effectiveness of transitioning from methadone to buprenorphine when necessary during pregnancy." | 3.88 | Transitioning from methadone to buprenorphine maintenance in management of opioid use disorder during pregnancy. ( Johnson, S; Martin, PR, 2018) |
| "Antenatal exposure to methadone or buprenorphine often causes neonatal abstinence syndrome (NAS) in newborns." | 3.88 | Antenatal methadone vs buprenorphine exposure and length of hospital stay in infants admitted to the intensive care unit with neonatal abstinence syndrome. ( Benjamin, DK; Bennett, MM; Clark, RH; Miller, ES; Murthy, K; Smith, PB; Tolia, VN, 2018) |
| "Our objective was to estimate the association between methadone and neonatal abstinence syndrome compared with buprenorphine using a probabilistic bias analysis to account for unmeasured confounding by severity of addiction." | 3.88 | Methadone Versus Buprenorphine for Opioid Use Dependence and Risk of Neonatal Abstinence Syndrome. ( Bodnar, LM; Caritis, SN; Lemon, LS; Platt, RW; Venkataramanan, R, 2018) |
| "Methadone is used for medication-assisted treatment of heroin addiction during pregnancy." | 3.88 | Prenatal methadone exposure is associated with altered neonatal brain development. ( Anblagan, D; Bastin, ME; Boardman, JP; Cabez, MB; Cooper, ES; Mactier, H; Monnelly, VJ; Quigley, A; Semple, SI, 2018) |
| "Two national cohorts of women receiving opioid maintenance treatment during pregnancy showed small but not statistically significant differences in neonatal outcomes in favour of buprenorphine compared with methadone." | 3.88 | Neonatal outcomes after fetal exposure to methadone and buprenorphine: national registry studies from the Czech Republic and Norway. ( Engeland, A; Gabrhelík, R; Handal, M; Lund, IO; Mravčík, V; Nechanská, B; Skurtveit, S, 2018) |
| "Increased use of methadone and buprenorphine in this study supports the feasibility of use of these medications during pregnancy and uptake of clinical recommendations for women with opioid use disorder." | 3.88 | Trends and Outcomes Associated With Using Long-Acting Opioids During Delivery Hospitalizations. ( D'Alton, ME; Duffy, CR; Friedman, AM; Kern-Goldberger, AR; Landau, R; Mourad, MJ; Siddiq, Z; Wright, JD, 2018) |
| " When medically indicated, limiting use of multiple psychiatric medications, particularly benzodiazepines and gabapentin, during pregnancy should be considered to improve NAS outcomes." | 3.88 | Impact of psychiatric medication co-exposure on Neonatal Abstinence Syndrome severity. ( Nikita, FNU; Saia, K; Schiff, DM; Shaw, D; Shrestha, H; Thomas, Z; Thomas-Lewis, JA; Wachman, EM; Warden, AH, 2018) |
| " Factors influencing adherence to buprenorphine during pregnancy have not been identified." | 3.88 | Buprenorphine medication-assisted treatment during pregnancy: An exploratory factor analysis associated with adherence. ( Catlin, D; Coker, JL; Knight, B; Ray-Griffith, S; Stowe, ZN, 2018) |
| "The use of implant naltrexone during pregnancy was not associated with higher rates of negative birth outcomes compared with methadone- and buprenorphine-exposed neonates." | 3.85 | A Retrospective Cohort Study of Birth Outcomes in Neonates Exposed to Naltrexone in Utero: A Comparison with Methadone-, Buprenorphine- and Non-opioid-Exposed Neonates. ( Hulse, G; Kelty, E, 2017) |
| "To report the presentation and characteristics of strabismus in children with prenatal methadone exposure." | 3.85 | Sensorimotor outcomes in children with prenatal exposure to methadone. ( Jansson, LM; Park, HJ; Yoo, SH, 2017) |
| "In this cohort, women taking ≥60mg of methadone during pregnancy were more likely to remain in treatment and to provide urine samples negative for illicit drugs." | 3.85 | Association of methadone dose with substance use and treatment retention in pregnant and postpartum women with opioid use disorder. ( Hosta, D; Wilder, CM; Winhusen, T, 2017) |
| "Maternal buprenorphine maintenance predisposes the infant to exhibit neonatal abstinence syndrome (NAS), but there is insufficient published information regarding the nature of NAS and factors that contribute to its severity in buprenorphine-exposed infants." | 3.85 | Maternal buprenorphine treatment and infant outcome. ( DiPietro, JA; Gandotra, N; Jansson, LM; Jones, H; King, VL; McConnell, K; Millio, L; Rios, R; Spencer, N; Tuten, M; Velez, ML, 2017) |
| " The standard of care for pregnant women with opioid use disorder is opioid maintenance therapy including either methadone or buprenorphine, which can be initiated at any time during pregnancy." | 3.85 | Delayed villous maturation in term placentas exposed to opioid maintenance therapy: a retrospective cohort study. ( Caritis, SN; Catov, JM; Lemon, LS; Mokhtari, NB; Parks, WT; Serra, AE; Venkataramanan, R, 2017) |
| "Using the retrospective matched cohort study design, 396 births to women on methadone treatment during pregnancy (the methadone-treated group) and 609 to women who started methadone treatment after childbirth (the heroin-exposed group) were identified in the National Methadone Maintenance Program." | 3.81 | Comparison of adverse obstetric outcomes and maternity hospitalization among heroin-exposed and methadone-treated women in Taiwan. ( Chen, CY; Ho, IK; Lien, YT; Su, LW; Yeh, HH, 2015) |
| "To compare neonatal abstinence syndrome prevalence and characteristics among neonates born to women prescribed buprenorphine and naloxone compared with methadone during pregnancy." | 3.81 | Buprenorphine and naloxone compared with methadone treatment in pregnancy. ( Jones, H; Seashore, C; Stringer, EM; Stuebe, AM; Thorp, J; Wiegand, SL, 2015) |
| "This article aims to describe neonatal outcomes, clinical correlates, and the rate for neonatal abstinence syndrome (NAS) for women on methadone maintenance therapy." | 3.81 | Maternal methadone treatment and neonatal abstinence syndrome. ( Faisal, M; Li, S; Liu, WF; Singh, K, 2015) |
| " The birth weights of methadone-exposed neonates of the women who tapered more than 50% were significantly higher than for the methadone-exposed neonates of the women tapering between 11 and 50%." | 3.81 | Tapering from Methadone or Buprenorphine during Pregnancy: Maternal and Neonatal Outcomes in Norway 1996-2009. ( Bakstad, B; Bjarkø, L; Ravndal, E; Skurtveit, S; Tanum, L; Waal, H; Welle-Strand, GK, 2015) |
| "Pregnant women filling at least one prescription for an opioid analgesic at any time during pregnancy for whom opioid exposure characteristics including duration of therapy: short term (<30 days) or long term (≥ 30 days); timing of use: early use (only in the first two trimesters) or late use (extending into the third trimester); and cumulative dose (in morphine equivalent milligrams) were assessed." | 3.81 | Exposure to prescription opioid analgesics in utero and risk of neonatal abstinence syndrome: population based cohort study. ( Bateman, BT; Desai, RJ; Hernandez-Diaz, S; Huybrechts, KF; Kaltenbach, K; Kerzner, LS; Mogun, H; Patorno, E, 2015) |
| "To describe obstetrical and neonatal outcomes including neonatal abstinence syndrome (NAS) in a Canadian cohort of methadone-maintained pregnant women." | 3.81 | Obstetrical and neonatal outcomes of methadone-maintained pregnant women: a canadian multisite cohort study. ( Abrahams, R; Graves, L; Kahan, M; Kim, T; Ordean, A, 2015) |
| "To identify and describe infant deaths presenting suddenly and unexpectedly in whom there was a history of maternal methadone consumption or misuse of drugs during pregnancy." | 3.81 | Maternal use of methadone and risk of sudden neonatal death. ( Cohen, MC; Coombs, RC; Morley, SR, 2015) |
| "To evaluate neonatal abstinence syndrome (NAS) treatment outcomes achieved using an optimized methadone weaning protocol developed using pharmacokinetic (PK) modeling compared with standard methadone weaning." | 3.81 | Cohort Analysis of a Pharmacokinetic-Modeled Methadone Weaning Optimization for Neonatal Abstinence Syndrome. ( Hall, ES; Meinzen-Derr, J; Wexelblatt, SL, 2015) |
| "The primary objective was to determine whether oral morphine sulfate contributed to decreased length of stay, both in the hospital and neonatal intensive care unit (NICU), when compared to oral methadone for the treatment of neonatal abstinence syndrome (NAS)." | 3.81 | Retrospective chart review comparing morphine and methadone in neonates treated for neonatal abstinence syndrome. ( Hager, SJ; Spurlock, D; Young, ME, 2015) |
| "Our PBPK model integrating prior physiological knowledge, in vitro and in vivo data, allowed successful prediction of methadone and glyburide disposition during pregnancy." | 3.80 | Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19. ( Ke, AB; Nallani, SC; Rostami-Hodjegan, A; Unadkat, JD; Zhao, P, 2014) |
| "To evaluate the effectiveness of methadone for the treatment of neonatal abstinence syndrome when used according to a preexisting clinical pathway." | 3.80 | Effectiveness of a clinical pathway with methadone treatment protocol for treatment of neonatal abstinence syndrome following in utero drug exposure to substances of abuse*. ( Bhatt-Mehta, V; Ng, CM; Schumacher, RE, 2014) |
| "In infants of methadone-prescribed opioid-dependent mothers mean birth weight was 259 g [95% confidence interval (CI) 214-303 g; P<0." | 3.80 | Reduced fetal growth in methadone-maintained pregnancies is not fully explained by smoking or socio-economic deprivation. ( Dryden, C; Mactier, H; Shipton, D; Tappin, DM, 2014) |
| " Three hundred ninety women were treated between 1994 and 2009 with buprenorphine (n = 77), methadone (n = 184), or slow-release oral morphine (SROM) (n = 129) on an outpatient basis throughout their pregnancy and postpartum period." | 3.80 | Characteristics and quality of life of opioid-dependent pregnant women in Austria. ( Comer, SD; Fischer, G; Metz, VE; Pribasnig, A; Wuerzl, J, 2014) |
| " Flash VEPs were recorded within 3 days of birth from 100 healthy infants of drug-misusing mothers prescribed substitute methadone during pregnancy and 50 comparison infants matched for birth weight, gestation, and socioeconomic deprivation." | 3.79 | Neonatal visual evoked potentials in infants born to mothers prescribed methadone. ( Boulton, R; Bradnam, MS; Hamilton, R; Mactier, H; McCulloch, DL; McGlone, L; Weaver, LT, 2013) |
| "This report, the first description of Italian cases of nystagmus related to use of methadone during pregnancy, underlies the importance of a careful investigation of drug use in pregnancy in cases of unexplained congenital nystagmus." | 3.79 | Congenital nystagmus in two infants born from mothers exposed to methadone during pregnancy. ( Battini, R; Cioni, G; Gamucci, A; Tinelli, F, 2013) |
| "To describe the prevalence of in utero alcohol and illicit drug exposure in infants born to mothers prescribed methadone in pregnancy, and to compare the accuracy of maternal interview with infant toxicology." | 3.79 | In utero drug and alcohol exposure in infants born to mothers prescribed maintenance methadone. ( Cooper, G; Hassan, H; Mactier, H; McGlone, L, 2013) |
| "Methadone maintenance treatment (MMT) is the standard of care during pregnancy for opioid-dependency, showing efficacy in improving prenatal care and reducing risk of relapse." | 3.79 | Rates of fetal polydrug exposures in methadone-maintained pregnancies from a high-risk population. ( Delano, K; Gareri, J; Koren, G, 2013) |
| "In Norway, most opioid-dependent women are in opioid maintenance treatment (OMT) with either methadone or buprenorphine throughout pregnancy." | 3.79 | Neonatal outcomes following in utero exposure to methadone or buprenorphine: a National Cohort Study of opioid-agonist treatment of Pregnant Women in Norway from 1996 to 2009. ( Bakstad, B; Bjarkø, L; Jones, HE; Ravndal, E; Skurtveit, S; Waal, H; Welle-Strand, GK, 2013) |
| "Limited pharmacological data are available to guide methadone treatment during pregnancy and postpartum." | 3.79 | Pharmacologic evidence to support clinical decision making for peripartum methadone treatment. ( Bogen, DL; Friedman, CR; Hanusa, BH; Helsel, JC; Nukui, T; Perel, JM; Romkes, M; Wisner, KL, 2013) |
| "This study aimed to (i) describe methadone dosing before, during and after pregnancy, (ii) to compare the incidence of neonatal abstinence syndrome (NAS) between those with dose decreases and those with steady or increasing doses and (iii) to describe prescribed medication use among opioid-dependent pregnant women." | 3.79 | Methadone dosing and prescribed medication use in a prospective cohort of opioid-dependent pregnant women. ( Carmody, D; Clarke, T; Cleary, BJ; Eogan, M; Fahey, T; Gallagher, PJ; Gleeson, J; McDermott, C; Murphy, DJ; O'Connell, MP; O'Sullivan, A; Reynolds, K; White, MJ, 2013) |
| " For opiate-addicted pregnant women, methadone is the treatment of choice and should be maintained throughout pregnancy, despite the manageable problem of neonatal opiate withdrawal." | 3.79 | Management of the pregnant substance abusing woman. ( Sheehan, M; Sheehan, MG, 2013) |
| "Pregnant women in methadone maintenance therapy may have poor nutrition during pregnancy." | 3.78 | A pilot study of the nutritional status of opiate-using pregnant women on methadone maintenance therapy. ( Bodnar, LM; Bogen, DL; Hanusa, BH; Tomedi, LE; Wisner, KL, 2012) |
| " Methadone use in pregnancy has been associated with adverse perinatal outcomes and neonatal abstinence syndrome (NAS)." | 3.78 | Methadone and perinatal outcomes: a prospective cohort study. ( Carmody, D; Clarke, T; Cleary, BJ; Eogan, M; Fahey, T; Gallagher, PJ; Gleeson, J; McDermott, C; Murphy, DJ; O'Connell, MP; O'Sullivan, A; White, MJ, 2012) |
| "One hundred fifty-two opioid-dependent pregnant women on methadone maintenance therapy (MMT) (n = 136) or buprenorphine maintenance therapy (BMT) (n = 16) during pregnancy and their neonates." | 3.78 | Opioid dependency in pregnancy and length of stay for neonatal abstinence syndrome. ( Hayes, MJ; Paul, JA; Pritham, UA, 2012) |
| "In a tertiary neonatal care center in Taiwan, three neonates whose mothers self-reported heroin abuse with methadone treatment during pregnancy were studied." | 3.78 | Perinatal effects of combined use of heroin, methadone, and amphetamine during pregnancy and quantitative measurement of metabolites in hair. ( Chang, YZ; Chen, JY; Chen, SC; Ng, YY; Su, PH; Yang, C, 2012) |
| "To identify maternal and neonatal factors that impact response to methadone therapy for neonatal abstinence syndrome." | 3.77 | Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome. ( Akinbi, H; Isemann, B; Meinzen-Derr, J, 2011) |
| "Determine whether infants exposed to chronic maternal methadone with abnormal intrapartum fetal heart rate (FHR) patterns are more likely to require treatment for neonatal abstinence syndrome (NAS)." | 3.77 | Association between intrapartum fetal heart rate patterns and neonatal abstinence syndrome in methadone exposed neonates. ( Albright, B; Brown, SA; Hsi, A; Leeman, LM; Rayburn, WF; Skipper, B, 2011) |
| "The purpose of this study was to examine the relationship among methadone maintenance treatment, perinatal outcomes, and neonatal abstinence syndrome." | 3.77 | Methadone and perinatal outcomes: a retrospective cohort study. ( Cleary, BJ; Donnelly, JM; Fahey, T; Gallagher, PJ; Murphy, DJ; Strawbridge, JD; White, MJ, 2011) |
| "05), birth weight, and neonatal morbidities were similar regardless of the maternal methadone dose." | 3.77 | Higher maternal doses of methadone does not increase neonatal abstinence syndrome. ( Bombrys, A; Grier, M; Habli, M; Livingston, J; Pizarro, D; Sibai, B, 2011) |
| "To examine the relationship between maternal opioid agonists, methadone, or buprenorphine (BPH), and concurrent psychiatric medication use on length of hospitalization (LOS) among infants with neonatal abstinence syndrome (NAS)." | 3.77 | The relationship between maternal opioid agonists and psychiatric medications on length of hospitalization for neonatal abstinence syndrome. ( Bauchner, H; Bonzagni, A; Byun, J; Newby, PK; Philipp, BL; Vreeland, J; Wachman, EM, 2011) |
| "Twenty-eight term infants that were exposed to methadone in utero and exhibited symptoms of neonatal abstinence syndrome (NAS) prior to hospital discharge were included into the study." | 3.77 | The impact of infant feeding method on neonatal abstinence scores of methadone-exposed infants. ( Gerlach, K; McQueen, KA; Montelpare, W; Murphy-Oikonen, J, 2011) |
| "This study found no differences in the pain responses of ME infants and non-exposed infants when given sucrose during heel lance procedures." | 3.76 | Efficacy of oral sucrose in infants of methadone-maintained mothers. ( Marceau, JR; Murray, H; Nanan, RK, 2010) |
| "This study suggests that a treatment of neonatal abstinence syndrome with clonidine in omission of opiates is possible without causing short-term adverse cardiovascular effects." | 3.76 | Treatment of neonatal abstinence syndrome with clonidine and chloral hydrate. ( Bastanier, C; Beske, F; Esmaeili, A; Keinhorst, AK; Schlösser, R; Schuster, T, 2010) |
| " Growth restriction was independent of the last maternal methadone dose and the cumulative methadone dose during pregnancy." | 3.76 | Growth restriction in pregnancies of opioid-dependent mothers. ( Cook, CM; Jones, MP; Liu, AJ; Nanan, R; Sithamparanathan, S, 2010) |
| "Infants born to drug-misusing mothers prescribed methadone in pregnancy are at risk of a range of visual problems, the underlying causes of which are not clear." | 3.76 | Ophthalmic, clinical and visual electrophysiological findings in children born to mothers prescribed substitute methadone in pregnancy. ( Bradnam, MS; Hamilton, R; MacKinnon, JR; Mactier, H; McGlone, L; Russell, HC, 2010) |
| "To estimate the relationship between maternal methadone dose and the incidence of neonatal abstinence syndrome (NAS)." | 3.76 | Relationship between maternal methadone dose at delivery and neonatal abstinence syndrome. ( Almario, CV; Baxter, JK; Berghella, V; Dysart, KC; Hayes, EJ; Seligman, NS, 2010) |
| "Methadone is standard pharmacotherapy for opioid-dependent pregnant women, yet the relationship between maternal methadone dose and neonatal abstinence syndrome (NAS) severity is still unclear." | 3.76 | Prenatal methadone exposure, meconium biomarker concentrations and neonatal abstinence syndrome. ( Choo, RE; Concheiro, M; Elko, A; Gray, TR; Huestis, MA; Jansson, LM; Jones, HE; Williams, E, 2010) |
| " This study aims to determine the infant mortality rate of infants born to women on a methadone program during pregnancy and to identify any modifiable risk factors." | 3.76 | Infant mortality among women on a methadone program during pregnancy. ( Burns, L; Conroy, E; Mattick, RP, 2010) |
| " This study compared the acoustic cry characteristics of infants born to mothers maintained on methadone during pregnancy with those of infants not exposed to methadone during pregnancy." | 3.75 | Acoustic cry characteristics of infants exposed to methadone during pregnancy. ( Quick, ZL; Robb, MP; Woodward, LJ, 2009) |
| "The purpose of this study was to examine high-dose methadone in pregnant women and its effect on the duration of neonatal abstinence syndrome." | 3.75 | High-dose methadone in pregnant women and its effect on duration of neonatal abstinence syndrome. ( Cordero, L; Gardner, DK; Lim, S; Prasad, MR; Samuels, P, 2009) |
| "Four hundred and fifty singleton pregnancies of drug-misusing women prescribed substitute methadone in pregnancy." | 3.75 | Maternal methadone use in pregnancy: factors associated with the development of neonatal abstinence syndrome and implications for healthcare resources. ( Dryden, C; Hepburn, M; Mactier, H; Young, D, 2009) |
| " This study investigated whether maternal methadone/buprenorphine dose and nicotine use in pregnancy affects the occurrence and duration of neonatal abstinence syndrome (NAS) in the infant." | 3.75 | Opioid maintenance treatment during pregnancy: occurrence and severity of neonatal abstinence syndrome. A national prospective study. ( Bakstad, B; Ravndal, E; Sarfi, M; Welle-Strand, GK, 2009) |
| "Empirical evidence is needed to guide adequate postpartum pain relief of methadone and buprenorphine stabilized patients." | 3.75 | Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy. ( Dahne, J; Johnson, R; Jones, HE; Lemoine, L; Milio, L; O'Grady, K; Ordean, A; Selby, P, 2009) |
| "Methadone is the therapeutic agent of choice for the treatment of opiate addiction in pregnancy." | 3.75 | The impact of cocaine and heroin on the placental transfer of methadone. ( Malek, A; Obrist, C; von Mandach, U; Wenzinger, S, 2009) |
| "Retrospective cohort study of 232 metropolitan and 67 rural infants born to mothers maintained on methadone throughout pregnancy for the treatment of opiate dependency, between January 2000 and December 2006." | 3.75 | Pregnancy and neonatal characteristics of opioid-dependent Indigenous Australians: a rural and metropolitan comparison. ( An, EI; Canalese, J; Liu, AJ; Nanan, R; Tetstall, E, 2009) |
| "Prior studies noted elevated preterm birth (PTB) rates among opiate-addicted women treated with methadone." | 3.75 | Risk factors for preterm birth among opiate-addicted gravid women in a methadone treatment program. ( Almario, CV; Baxter, JK; Berghella, V; Dysart, KC; Seligman, NS, 2009) |
| "To describe the patterns of screening for hepatitis C virus (HCV) infection in methadone-maintained pregnant women and their infants." | 3.75 | Screening for hepatitis C virus infection in methadone-maintained mothers and their infants. ( An, EI; Leroi, MJ; Liu, AJ; Murray, HG; Nanan, RK; Tetstall, E, 2009) |
| "Methadone-maintained pregnant patients with mood disorders have compromised treatment outcomes ( [1] )." | 3.75 | The impact of mood disorders on the delivery and neonatal outcomes of methadone-maintained pregnant patients. ( Chisolm, MS; Fitzsimons, H; Heil, SH; Jones, HE; O'Grady, KE; Tuten, M, 2009) |
| "Majority of neonates born to mothers on methadone exhibit neonatal abstinence syndrome and require pharmacological treatment." | 3.74 | Neonatal abstinence syndrome. ( Kurian, O; Serane, VT, 2008) |
| " Maternal and neonatal outcomes were evaluated, including cholestasis of pregnancy, preterm birth, low birth weight, neonatal intensive care unit admissions, and neonatal methadone withdrawal." | 3.74 | Chronic hepatitis C in pregnancy. ( Arora, S; Berkley, EM; Dunkelberg, JC; Leslie, KK; Qualls, C, 2008) |
| " Use of heroin alone during pregnancy was recorded in 51 women (50%), methadone alone in 6 (7%), and a combination of heroin and methadone in 9 (11%)." | 3.74 | Maternal and neonatal effects of substance abuse during pregnancy: our ten-year experience. ( Banovic, I; Bucat, M; Capkun, V; Roje, D; Vucinovic, M; Vucinovic, Z, 2008) |
| "To examine the association between retention in methadone treatment during pregnancy and key neonatal outcomes." | 3.74 | Methadone in pregnancy: treatment retention and neonatal outcomes. ( Burns, L; Lim, K; Mattick, RP; Wallace, C, 2007) |
| "Descriptive analysis of data in live births of women enrolled in a methadone maintenance programme in 1991-1994 (n = 78) and 1997-2001 (n = 98), including time spent in hospital, treatment for neonatal abstinence syndrome (NAS), admission to the neonatal medical unit (NMU) and follow-up for child health checks." | 3.74 | Methadone-exposed newborn infants: outcome after alterations to a service for mothers and infants. ( D'Souza, SW; Macrory, F; Miles, J; Sims, DG; Sugumar, K, 2007) |
| "We determined the effect of preterm delivery on the course of neonatal abstinence syndrome (NAS) in infants born to mothers participating in a methadone maintenance program." | 3.74 | Sequela of preterm versus term infants born to mothers on a methadone maintenance program: differential course of neonatal abstinence syndrome. ( Dysart, K; Greenspan, JS; Hsieh, HC; Kaltenbach, K, 2007) |
| "Sixty-eight patients treated with methadone for opiate dependence during pregnancy (vaginal n=35; cesarean n=33) were matched retrospectively to control women." | 3.74 | Intrapartum and postpartum analgesia for women maintained on methadone during pregnancy. ( Benvenuto, A; Howard, D; Meyer, M; Plante, D; Wagner, K, 2007) |
| "The objective of this study was to determine the population prevalence and correlates of neonatal abstinence syndrome among neonates born to women on methadone, using a cross-sectional analysis of linked population health data." | 3.74 | Using population data to examine the prevalence and correlates of neonatal abstinence syndrome. ( Burns, L; Mattick, RP, 2007) |
| "We selected 32 women in the city of Vancouver known to have used heroin or methadone during pregnancy between October 2001 and December 2002." | 3.74 | Rooming-in compared with standard care for newborns of mothers using methadone or heroin. ( Abrahams, RR; Janssen, PA; Kelly, SA; Mackintosh, J; Payne, S; Thiessen, PN, 2007) |
| "Statistically birth weight of newborns was significantly lowest in the group of heroin-addicted women as compared to the group receiving substitution with buprenorphine p<0." | 3.74 | [The effect of substitution therapy on the birth weight of the newborn, its postpartum adaptation, trophic and course of the neonatal abstinence syndrome]. ( Binder, T; Vavrinková, B, 2007) |
| "This study was undertaken to evaluate the adequacy of a hospital formulated oral morphine preparation for management of neonatal abstinence syndrome (NAS) and to compare clinical features in infants exposed to methadone or buprenorphine in utero." | 3.74 | Hospital morphine preparation for abstinence syndrome in newborns exposed to buprenorphine or methadone. ( Bues-Charbit, M; Busuttil, M; Colombini, N; Dubuc, M; Einaudi, MA; Elias, R, 2008) |
| "To assess potential risks related to the duration or total amount of fetal methadone exposure during gestation, we compared babies of women who conceived and maintained on methadone throughout pregnancy with babies of women who began methadone treatment during the second or third trimester." | 3.74 | Outcomes of neonates conceived on methadone maintenance therapy. ( Biles, LA; Leamon, MH; McCarthy, JJ; Stenson, G, 2008) |
| "Data from this non-randomized comparison suggest that buprenorphine may offer advantages for treatment of opiate dependence during pregnancy." | 3.74 | Buprenorphine and methadone treatment of opiate dependence during pregnancy: comparison of fetal growth and neonatal outcomes in two consecutive case series. ( Heilig, M; Kakko, J; Sarman, I, 2008) |
| "Although methadone maintenance is the standard treatment of opiate addiction in pregnancy, opinion as to its utility is divided." | 3.73 | Methadone maintenance program in a Swiss perinatal center: (I): Management and outcome of 89 pregnancies. ( Arlettaz, R; Hebisch, G; Kashiwagi, M; Lauper, U; Zimmermann, R, 2005) |
| "The aim of the study was to analyze the neonatal impact of a methadone maintenance program in pregnancy, and the social resources of the families involved." | 3.73 | Methadone maintenance program in pregnancy in a Swiss perinatal center (II): neonatal outcome and social resources. ( Arlettaz, R; Bucher, HU; Das-Kundu, S; Fauchère, JC; Kashiwagi, M; Lang, A, 2005) |
| "This study assesses the effect of higher doses of methadone during pregnancy on maternal and fetal outcomes." | 3.73 | High-dose methadone maintenance in pregnancy: maternal and neonatal outcomes. ( Anania, B; Leamon, MH; McCarthy, JJ; Parr, MS, 2005) |
| " Women who took heroin in later pregnancy were significantly more likely than women who were stabilised on methadone to have a baby who needed morphine (40% versus 19%), had higher mean maximum neonatal abstinence scores (NAS) (5." | 3.73 | Pregnancy outcome in women who use opiates. ( Armstrong, D; Fajemirokun-Odudeyi, O; Lindow, SW; Pairaudeau, P; Phillips, T; Sinha, C; Tutty, S, 2006) |
| "Measurement of plasma methadone concentration to investigate the rate of clearance of methadone prescribed for heroin dependence in the first, second and third trimesters of pregnancy." | 3.73 | Changes to methadone clearance during pregnancy. ( Boys, A; Hay, A; Raistrick, D; Rostami-Hodjegan, A; Wolff, K, 2005) |
| "To assess the outcomes of infants born to mothers receiving methadone for the management of pain in pregnancy." | 3.72 | Outcomes of infants born to mothers receiving methadone for pain management in pregnancy. ( Kuschel, C; Sharpe, C, 2004) |
| "To assess the usefulness of cord and serum methadone concentrations at 2 days of age in predicting the severity of neonatal abstinence syndrome (NAS) in infants whose mothers received methadone during pregnancy." | 3.72 | Can methadone concentrations predict the severity of withdrawal in infants at risk of neonatal abstinence syndrome? ( Austerberry, L; Cornwell, M; Couch, R; Kuschel, CA; Rowley, RS, 2004) |
| "The purpose of this study is to evaluate women receiving methadone maintenance during pregnancy." | 3.70 | Methadone maintenance in pregnancy: a reappraisal. ( Britton, KA; Brizendine, E; Brown, HL; Hiett, AK; Mahaffey, D; Turnquest, MA, 1998) |
| " She developed post-dural puncture headache (PDPH) on the third postpartum day which was managed by palliative measures: bed rest (patient's position of choice), increased hydration (water: 3 litres po per day), lysine acetyl salicylate (5." | 3.70 | Unilateral trigeminal and facial nerve palsies associated with epidural analgesia in labour. ( Agustí, M; Carrero, EJ; Fábregas, N; Fernández, C; Valldeoriola, F, 1998) |
| "The volume of feeds, changes in infant body weight, as well as occurrence of adverse clinical effects in infants withdrawing from methadone were studied during the first month of life." | 3.70 | Hyperphagia in neonates withdrawing from methadone. ( Kastner, B; Martinez, A; Taeusch, HW, 1999) |
| "Lower peak doses of TOS and shorter dosing intervals may be associated with shorter hospital stays for infants with neonatal abstinence syndrome secondary to maternal methadone treatment." | 3.70 | Shorter dosing interval of opiate solution shortens hospital stay for methadone babies. ( Jones, HC, 1999) |
| " Women who reduced their methadone dose during pregnancy delivered babies of significantly higher birth weight than those whose methadone dose remained the same or increased (median 3027 g, range 1780-3629 g vs 2645 g, range 580-3720 g)." | 3.70 | Outcome predictors in pregnant opiate and polydrug users. ( McCarthy, JE; Ruben, SM; Shaw, NJ; Siney, C, 1999) |
| " The majority of women in the CDU clinic were treated for narcotic addiction with methadone (90%) but most continued to use heroin during pregnancy (68%)." | 3.70 | The drug epidemic: effects on newborn infants and health resource consumption at a tertiary perinatal centre. ( Davis, PG; Henschke, PN; Kelly, JJ, 2000) |
| " The drug-dependent women had used combinations of methadone, heroin, cocaine and other drugs during pregnancy." | 3.69 | Development after prenatal exposure to cocaine, heroin and methadone. ( Akkerhuis, GW; Gunning, WB; Soepatmi, S; van Baar, AL, 1994) |
| "We examined the effect of methadone treatment, duration of Medicaid enrollment during pregnancy, and other maternal characteristics on receipt of prenatal care by 2,254 women infected with human immunodeficiency virus (HIV) delivering a singleton in New York state from 1985 through 1990." | 3.69 | Prenatal care of HIV-infected women: analysis of a large New York State cohort. ( Cocroft, J; Fanning, T; Hauck, W; Markson, L; Turner, BJ, 1995) |
| "A prospective longitudinal study on the development of children of drug-dependent mothers who used combinations of cocaine, heroin and methadone during pregnancy was carried out in Amsterdam." | 3.69 | Cognitive development at preschool-age of infants of drug-dependent mothers. ( de Graaff, BM; van Baar, A, 1994) |
| " Persistent weight retardation at 12 months was correlated with methadone dosage during pregnancy, but not the need for phenobarbitone therapy." | 3.69 | Infants born to narcotic dependent mothers: physical growth patterns in the first 12 months of life. ( Chant, DC; Gray, PH; Hayes, AJ; Tudehope, DI; Vance, JC, 1997) |
| "This spectrum of relationships supports the concept that careful reduction of the maternal methadone dosage during pregnancy under intensive medical and psychosocial surveillance may benefit the drug-exposed new-born infant clinically." | 3.68 | Relationship between maternal methadone dosage, maternal-neonatal methadone levels, and neonatal withdrawal. ( Doberczak, TM; Friedmann, P; Kandall, SR, 1993) |
| " Both of the mothers were on methadone maintenance for narcotic dependency prior to the diagnosis of pregnancy." | 3.68 | Diazepam abuse in pregnant women on methadone maintenance. Implications for the neonate. ( Hinderliter, SA; Sutton, LR, 1990) |
| "This paper describes patterns of drug use such as choice of drug, other substances abused, and route of administration in 174 women who reported methamphetamine, cocaine, heroin, or "Ts and blues" abuse during pregnancy." | 3.68 | Patterns of multiple substance abuse during pregnancy: implications for mother and fetus. ( Gilstrap, LD; Johnston, WL; Little, BB; Snell, LM, 1990) |
| " To conduct an exploratory study of opiate effects in humans, we compared the sex-dimorphic behavior of male and female offspring of women maintained on methadone during pregnancy to that of demographically matched control subjects." | 3.68 | Effects of prenatal methadone exposure on sex-dimorphic behavior in early school-age children. ( Johnson, HL; Meyer-Bahlburg, HF; Rosen, TS; Sandberg, DE, 1990) |
| " Apnea density and episodes of periodic breathing exceeded the 95th percentile for normal infants in 12 (38%) of 32 of cocaine-exposed infants vs only 1 (6%) of 18 opiate-exposed infants." | 3.67 | Prenatal cocaine exposure is associated with respiratory pattern abnormalities. ( Chasnoff, IJ; Hunt, CE; Kaplan, D; Kletter, R, 1989) |
| "This report describes a case in which cocaine abuse during pregnancy was related temporally to abruptio placentae, preterm labour and to rapid delivery." | 3.67 | Perinatal cocaine intoxication. ( Collins, E; Hardwick, RJ; Jeffery, H, 1989) |
| "To determine the effects of human immunodeficiency virus (HIV) infection on pregnancy outcomes, we prospectively studied female intravenous drug users in a methadone program in New York City." | 3.67 | Prospective study of human immunodeficiency virus infection and pregnancy outcomes in intravenous drug users. ( Davenny, K; Feingold, AR; Friedland, GH; Klein, RS; Mayers, MM; Robertson, VJ; Rogers, MF; Schoenbaum, EE; Selwyn, PA; Shulman, JF, 1989) |
| "Rat pups were exposed in utero to the opiates methadone or buprenorphine by administering subcutaneous injections to the mothers daily for the duration of pregnancy." | 3.67 | Effects of exposure in utero to methadone and buprenorphine on enkephalin levels in the developing rat brain. ( Olley, JE; Tiong, GK, 1988) |
| "A generally accepted management of heroin addiction during pregnancy is treatment with methadone, which reduces the complications of heroin addiction considerably." | 3.67 | The effect of chronic methadone treatment on intra-uterine growth of the cynomolgus monkey (Macaca fascicularis). ( Frencken, HJ; Hein, PR; Schatorjé, JS, 1988) |
| "In 50 infants born to women who continued to take heroin during all or part of their pregnancy the drug withdrawal symptoms were mild and were noted in 21 infants (42%)." | 3.67 | Maternal narcotic abuse and the newborn. ( Alroomi, LG; Davidson, J; Evans, TJ; Galea, P; Howat, R, 1988) |
| "The authors describe their experience with methadone treatment in pregnancy." | 3.67 | Methadone in pregnancy: clinical-toxicological aspects. ( Chiarotti, M; De Giovanni, N; Falasconi, AM; Offidani, C, 1986) |
| "Female rats were given different doses of methadone for the whole duration of pregnancy." | 3.67 | Fetal addiction to methadone: postnatal abstinence syndrome and development of visual evoked potentials. ( Onofrj, M; Pinto, F; Pola, P; Tempesta, E; Torrioli, MG, 1986) |
| "We studied the influence of human pregnancy on the maternal disposition and effects of methadone." | 3.67 | Altered methadone pharmacokinetics in methadone-maintained pregnant women. ( Benowitz, NL; Kreek, MJ; Pond, SM; Raghunath, J; Tong, TG, 1985) |
| " These two groups were compared with a group of women who had used narcotics in the past and were maintained on methadone during pregnancy, and with a group of drug-free women." | 3.67 | Cocaine use in pregnancy. ( Burns, KA; Burns, WJ; Chasnoff, IJ; Schnoll, SH, 1985) |
| "This article explores the issues raised by methadone maintenance during pregnancy with a focus on intervention techniques for the drug counselor." | 3.67 | When the client is pregnant: information for counselors. ( Williams, A, 1985) |
| "This study compares the first year's health, neurodevelopmental status, and environment of infants of drug-dependent mothers attending methadone programs during pregnancy with those of drug-dependent mothers not enrolled in treatment programs (untreated)." | 3.66 | Follow-up of methadone-treated and untreated narcotic-dependent women and their infants: health, developmental, and social implications. ( Desmond, MM; Wait, RB; Wilson, GS, 1981) |
| "Blood levels of ACTH, FSH, and estriol were measured throughout the estrous cycle and estriol was determined at different stages during pregnancy in Charles River CD-1 mice treated with 10 mg/kg/day of methadone or vehicle (physiological saline)." | 3.66 | Acute and subchronic effects of methadone on the blood hormonal levels of pregnant and nonpregnant Charles River CD-1 mice. ( Bui, QQ; Tran, MB; West, WL, 1983) |
| "The effects of maternal use of methadone during pregnancy on tests of thyroid function were studied in 14 women and their offspring." | 3.66 | Effects of methadone on thyroid function in mother, fetus, and newborn. ( Chandavasu, O; Dube, SK; Evans, HE; Glass, L; Jhaveri, RC; Khan, F; Rosenfeld, W; Salazar, JD, 1980) |
| "Minute ventilation, end-tidal PCO2, O2 and CO2 concentrations in expired air, pulse rate and arterial blood pressure were measured in the last half of pregnancy in eight women taking methadone daily." | 3.66 | Respiratory and hemodynamic effects of methadone in pregnant women. ( Dunham, MJ; Krall, MA; Metcalfe, J; Olsen, GD, 1980) |
| "Offspring from methadone-treated Wistar rats (last trimester of pregnancy), as compared to ad lib and pair fed controls, showed a reduction of body growth which continued throughout the 28-day period during which animals were observed after birth." | 3.66 | Prenatal exposure to methadone HCL in relationship to body and brain growth in the rat. ( Ford, DH; Rhines, RK, 1979) |
| "A review of research concerning the effects of methadone on infants born to mothers who received the drug during their pregnancy is presented." | 3.66 | The congenitally methadone-addicted infant. ( Fleming, JW; Rosser, P, 1979) |
| "To determine clinical and analytical feasibility of studies of narcotic disposition in the perinatal period, an initial prospective study of methadone disposition in one female, in chronic methadone treatment for heroin addiction, throughout pregnancy and in her neonate have been carried out." | 3.66 | Methadone disposition during the perinatal period in humans. ( Kreek, MJ, 1979) |
| "Body weight gain and food and water consumption of female rats receiving daily methadone injections (5 mg/kg) intraperitoneally prior to mating and during gestation and lactation were studied." | 3.66 | Effects of chronic methadone treatment on maternal body weight and food and water consumption in rats. ( McLaughlin, PJ; White, WJ; Zagon, IS, 1978) |
| " Heroin abuse declined while methadone usage increased during those years." | 3.65 | The narcotic-dependent mother: fetal and neonatal consequences. ( Albin, S; Eidelman, A; Gartner, LM; Kandall, SR; Lee, KS; Lowinson, J, 1977) |
| "The course of pregnancy and delivery in 28 women under closely supervised methadone maintenance (group 1) was compared with that of 57 women using heroin or methadone under less controlled circumstances (group 2) and with that of 30 women free of mood-altering medications (group 3)." | 3.65 | Narcotic dependency in pregnancy. Methadone maintenance compared to use of street drugs. ( Adamsons, K; Stimmel, B, 1976) |
| " Mean birthweight of infants born to mothers abusing heroin during the pregnancy was 2,490 gm, an effect primarily of intrauterine growth retardation." | 3.65 | Differential effects of maternal heroin and methadone use on birthweight. ( Albin, S; Berle, B; Eidelman, AI; Gartner, LM; Kandall, SR; Lowinson, J, 1976) |
| "A pregnant patient in the midtrimester of pregnancy was begun on a methadone detoxification program." | 3.65 | Fetal stress from methadone withdrawal. ( Davis, R; Gumpel, JA; Madden, J; Mejia-Zelaya, A; Zuspan, FP, 1975) |
| " Morphine was detected in significant amounts in maternal and fetal urine regardless of whether the mother was on a methadone program or whether she denied any use of heroin during the last trimester of pregnancy." | 3.65 | A study of factors that influence the severity of neonatal narcotic withdrawal. ( Chavez, CJ; Ostrea, EM; Strauss, ME, 1975) |
| "Drug addiction during pregnancy has been managed in two ways: the detoxification program and the methadone-maintenance treatment program." | 3.65 | Drug addiction in pregnancy and the neonate. ( Ackerman, BD; Blinick, G; Jerez, E; Wallach, RC, 1976) |
| "Methadone maintenance treatment (MMT) is the gold standard for pregnant women with opioid use disorders." | 2.84 | Newborn birth-weight of pregnant women on methadone or buprenorphine maintenance treatment: A national contingency management approach trial. ( Adelson, M; Peles, E; Sason, A; Schreiber, S, 2017) |
| "Opioid use disorder is a significant global issue and the rate of opioid use in women of childbearing age and pregnant women is on the rise." | 2.82 | Ophthalmic outcomes in children exposed to opioid maintenance treatment in utero: A systematic review and meta-analysis. ( Baldacchino, A; Conti, AA; Hemmati, Z, 2022) |
| "RR of SIDS between drug-exposed and control infants." | 2.82 | SIDS is associated with prenatal drug use: a meta-analysis and systematic review of 4 238 685 infants. ( Makarious, L; Oei, JL; Teng, A, 2022) |
| " Specific areas of focus elaborated by the authors include: better characterization of opioid selection and dosing in managing labor analgesia, effectiveness of different regional anesthetic techniques, non-pharmacologic management, and psycho-social support for these patients." | 2.82 | Opioid Use Disorder in Pregnant Patients. ( Nathan, N, 2022) |
| "Smoking during pregnancy is the leading preventable cause of poor pregnancy outcomes in the United States." | 2.78 | Illicit drug use among pregnant women enrolled in treatment for cigarette smoking cessation. ( Bernstein, IM; Gaalema, DE; Heil, SH; Higgins, ST; Pepin, CS, 2013) |
| "Lessons learned in research and treatment of opioid dependence demonstrate the need to include pregnant women in clinical trials." | 2.78 | Lessons learned from a comparison of evidence-based research in pregnant opioid-dependent women. ( Baewert, A; Fischer, G; Graf-Rohrmeister, K; Jagsch, R; Langer, M; Thau, K; Unger, A; Winklbaur-Hausknost, B, 2013) |
| "How best to measure the occurrence of adverse events during a randomized clinical trial is an issue that has not been adequately examined in the research literature." | 2.77 | Nonserious adverse events in randomized trials with opioid-dependent pregnant women: direct versus indirect measurement. ( Arria, AM; Coyle, MG; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; O'Grady, KE; Selby, P; Stine, SM, 2012) |
| "Buprenorphine compared with methadone appears to result in less suppression of mean fetal heart rate, fetal heart rate reactivity and the biophysical profile score after medication dosing and these findings provide support for the relative safety of buprenorphine when fetal indices are considered as part of the complete risk-benefit ratio." | 2.77 | Fetal assessment before and after dosing with buprenorphine or methadone. ( Coyle, MG; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; O'Grady, KE; Salisbury, AL; Stine, SM; Weninger, M, 2012) |
| " Pregnant women (and parents with children) were forced to negotiate dosing in dangerous conditions." | 2.72 | Changing Outdated Methadone Regulations That Harm Pregnant Patients. ( Jones, HE; McCarthy, JJ; Rudolf, VP; Terplan, M; von Klimo, MC, 2021) |
| "Intensive treatment for nicotine dependence, environmental interventions, and innovative harm reduction strategies are recommended to address the barriers to quitting observed in this population of pregnant women." | 2.71 | Motivational enhancement therapy for nicotine dependence in methadone-maintained pregnant women. ( Diclemente, C; Haug, NA; Svikis, DS, 2004) |
| "Methadone was first given to all patients within 24h of treatment admission." | 2.71 | Randomized controlled study transitioning opioid-dependent pregnant women from short-acting morphine to buprenorphine or methadone. ( Jasinski, DR; Johnson, RE; Jones, HE; Milio, L, 2005) |
| "This study evaluated a novel drug abuse treatment, the Therapeutic Workplace." | 2.70 | A reinforcement-based therapeutic workplace for the treatment of drug abuse: six-month abstinence outcomes. ( Bigelow, GE; Robles, E; Silverman, K; Stitzer, ML; Svikis, D, 2001) |
| "Perinatal prognosis of pregnant drug abusers is better with intensive prenatal care and substitution maintenance programs." | 2.70 | [Withdrawal syndromes of newborns of pregnant drug abusers maintained under methadone or high-dose buprenorphine: 246 cases]. ( Aubisson, S; Cneude, F; Gourarier, L; Lejeune, C; Piquet, M; Simmat-Durand, L, 2001) |
| "A retrospective, inception cohort, nonrandomized control design was employed to evaluate the effects of daily vs twice daily dosing of methadone on opiate/cocaine use, and noncompliance with urine toxicology requests in methadone-maintained pregnant women, n = 45." | 2.68 | Methadone dosing and pregnancy: impact on program compliance. ( DePetrillo, PB; Rice, JM, 1995) |
| "Opioid use during pregnancy has serious consequences for mother and baby." | 2.66 | Management and monitoring of opioid use in pregnancy. ( Ibsen, IO; Jørgensen, JS; Lamont, RF; Rausgaard, NLK; Ravn, P, 2020) |
| "Many patients with opioid use disorder are treated in primary care, where effective addiction treatment can be provided." | 2.61 | Opioid Use Disorder: Medical Treatment Options. ( Coffa, D; Snyder, H, 2019) |
| "Treatment with buprenorphine or methadone is associated with NOWS, but neither medication appears to have significant adverse effects on early childhood development." | 2.61 | Opioid Use in Pregnancy. ( Forray, A; Habecker, E; Tobon, AL, 2019) |
| "Women with opioid use disorder who become pregnant are a particularly vulnerable population and require a comprehensive treatment approach for mother and fetus." | 2.61 | Opioid use disorder during pregnancy: An overview. ( Carter, LC; Nicholas, JS; Read, L; Read, MA; Schmidt, E, 2019) |
| "Methadone is a long-acting mu-opioid receptor agonist that has been shown to increase retention in treatment programs and attendance at prenatal care while decreasing pregnancy complications." | 2.61 | Pharmacological treatment of opioid use disorder in pregnancy. ( Klie, KA; Rodriguez, CE, 2019) |
| "When opioid misuse rises in the United States, pregnant women and their neonates are affected." | 2.61 | Analgesia, Opioids, and Other Drug Use During Pregnancy and Neonatal Abstinence Syndrome. ( Jones, HE; Kraft, WK, 2019) |
| "Options for treatment of opioid dependence, acute pain management, and perioperative multimodal analgesia are discussed." | 2.55 | Peripartum Anesthetic Management of the Opioid-tolerant or Buprenorphine/Suboxone-dependent Patient. ( Pan, A; Zakowski, M, 2017) |
| "Methadone is a valid option, but its safety profile is not completely known." | 2.55 | Neonatal Abstinence Syndrome: Update on Diagnostic and Therapeutic Strategies. ( Agosti, M; Allegaert, K; Cavallaro, G; Fumagalli, M; Mosca, F; Raffaeli, G; Tibboel, D; Wildschut, ED, 2017) |
| "Pregnant women with opioid use disorder can be treated with methadone, buprenorphine, or naltrexone to reduce opioid use and improve retention to treatment." | 2.55 | Methadone, Buprenorphine, and Naltrexone for the Treatment of Opioid Use Disorder in Pregnant Women. ( Griffin, BL; Stone, RH; Todd, TJ; Tran, TH; Vest, KM, 2017) |
| " Recommendations are made for further research into physician/patient interactions and into optimal dosing of methadone and buprenorphine to minimize maternal/fetal withdrawal." | 2.55 | Opioid dependence and pregnancy: minimizing stress on the fetal brain. ( Fassbender, C; Finnegan, LP; Leamon, MH; McCarthy, JJ, 2017) |
| "Recommendations and options for treating postoperative pain in patients on methadone and buprenorphine are outlined below." | 2.53 | New Pain Management Options for the Surgical Patient on Methadone and Buprenorphine. ( Arulkumar, S; Cornett, EM; Flower, RR; Fox, CJ; Gayle, JA; Kaye, AD; Sen, S, 2016) |
| "Methadone has been the mainstay of maintenance treatment for nearly 50 years, but recent research has found that both methadone and buprenorphine maintenance treatments significantly improve maternal, fetal and neonatal outcomes." | 2.52 | Pharmacological Management of Opioid Use Disorder in Pregnant Women. ( Wilder, CM; Winhusen, T, 2015) |
| "Methadone maintenance treatment (MMT) helps individuals with an opioid use disorder abstain from or decrease use of illegal or nonmedical opiates." | 2.50 | Medication-assisted treatment with methadone: assessing the evidence. ( Daniels, AS; Delphin-Rittmon, ME; Dougherty, RH; Fullerton, CA; Ghose, SS; Kim, M; Lyman, DR; Montejano, LB; Thomas, CP, 2014) |
| "Buprenorphine is a newer treatment for maternal opioid addiction and appears to result in a milder withdrawal syndrome than methadone." | 2.50 | Neonatal opioid withdrawal syndrome. ( Hsi, A; Leeman, L; Sutter, MB, 2014) |
| "Managing opioid dependence in pregnant women is a complex and potentially challenging task." | 2.49 | Managing opioid dependence in pregnancy -- a general practice perspective. ( Arunogiri, S; Foo, L; Frei, M; Lubman, DI, 2013) |
| "Birth weight was higher in the buprenorphine group in the two trials that could be pooled (mean difference (MD) -365." | 2.49 | Maintenance agonist treatments for opiate-dependent pregnant women. ( Amato, L; Bellisario, C; Davoli, M; Ferri, M; Minozzi, S, 2013) |
| "Neonatal abstinence syndrome has become a growing concern in infants born to substance-abusing mothers in the State of Florida." | 2.49 | Pharmacologic management of neonatal abstinence syndrome in a community hospital. ( Calhoun, DA; Napolitano, A; Seng, SK; Theophilopoulos, D, 2013) |
| "Methadone maintenance treatment has definite advantages for the mother and is currently recommended in the UK." | 2.47 | The management of heroin misuse in pregnancy: time for a rethink? ( Mactier, H, 2011) |
| " With respect to the particular consumed drug substances other than opioids during pregnancy variable forms of teratogenic and toxic effects can be assigned to the baby." | 2.47 | [Pregnant opioid addicted patients and additional drug intake. Part I. Toxic effects and therapeutic consequences]. ( Havemann-Reinecke, U; Hoell, I, 2011) |
| "Methadone is a long-acting synthetic opioid with high affinity for various opioid receptors, especially for m-opioid receptors." | 2.45 | [Methadone treatment and its dangers]. ( Jodziūniene, L; Lazauskas, R; Reingardiene, D, 2009) |
| "Women using methadone for treatment of opioid dependence should not be discouraged from breastfeeding." | 2.44 | Methadone exposure during lactation. ( Finkelstein, Y; Garcia-Bournissen, F; Glatstein, MM; Koren, G, 2008) |
| "The management of opioid dependence during pregnancy has received considerable attention over the past three decades." | 2.44 | Opioid dependence and pregnancy. ( Fischer, G; Jung, E; Winklbaur, B, 2008) |
| " These recommendations address: antepartum issues including treatment, dosage and pharmacological considerations, medical conditions and lab tests, intrapartum issues, postpartum concerns including breastfeeding, neonatal withdrawal, and developmental effects associated with methadone." | 2.41 | Clinical management of methadone dependence during pregnancy. ( Curet, LB; Dorato, V; Wallerstedt, C; Wilbourne, P, 2001) |
| "Methadone maintenance for the treatment of opioid dependence is described in this article." | 2.40 | Opioid dependence during pregnancy. Effects and management. ( Berghella, V; Finnegan, L; Kaltenbach, K, 1998) |
| "With methadone treatment, there is a decline in the amount of heroin used and in the number of injections." | 2.40 | [Substitution therapy of drug addicts]. ( Kopferschmitt, J; Weber, JC, 1998) |
| "Although substance use has been a worldwide problem at all levels of society since ancient times, recent attention has been focused on the use of legal and illegal substances by the pregnant woman." | 2.38 | The consequences of prenatal substance use for the developing fetus, newborn, and young child. ( Behnke, M; Eyler, FD, 1993) |
| "Methadone has been used for substitution in the US." | 2.38 | [Drug abuse, pregnancy and HIV infection]. ( Beck, L; Bender, HG; Halberstadt, E; Hartmann, L; Jahn, K, 1991) |
| "Methadone maintenance is an important component of the management of many pregnant opioid addicts." | 2.38 | Narcotic use in pregnancy. ( Hoegerman, G; Schnoll, S, 1991) |
| "Management of patients with opioid use disorder during the acute postpartum period remains clinically challenging as obstetricians aim to mitigate postdelivery pain while optimizing recovery support." | 1.91 | A comparison of postpartum opioid consumption and opioid discharge prescriptions among opioid-naïve patients and those with opioid use disorder. ( Achu, R; Bateman, BT; Gibbs, L; Guang, Z; Holland, E; Saia, K; Spence, NZ; Wachman, EM; Werler, MM; Young, M, 2023) |
| "Methadone-based treatment for pregnant women with opioid use disorder is quite prevalent in the clinical environment." | 1.91 | Perturbed neurochemical and microstructural organization in a mouse model of prenatal opioid exposure: A multi-modal magnetic resonance study. ( Atwood, BK; Grecco, GG; Shahid, SS; Wu, YC, 2023) |
| "Medications for opioid use disorder (MOUDs), including methadone, buprenorphine and naltrexone, are associated with lower death rates and improved quality of life for people in recovery from opioid use disorder (OUD)." | 1.72 | Examining differences in retention on medication for opioid use disorder: An analysis of Ohio Medicaid data. ( Ashmead, R; Bailey, E; Bickert, T; Bonny, AE; Doogan, NJ; Mack, A; Schmidt, S; Tossone, K; Zhang, P, 2022) |
| " However, evidence to guide appropriate dosing of pharmacotherapy for the treatment of opioid use disorder, such as methadone, based on self-reported opioid use during pregnancy is limited." | 1.72 | Does self-reported consumption of heroin correlate with dose of methadone among pregnant people with opioid use disorder? ( Arlandson, ME; Gonzalez, AM; Patel, A; Premkumar, A, 2022) |
| "Characterize severity of opioid use disorder during pregnancy over time." | 1.72 | Trends in the severity of opioid use disorder during pregnancy over time. ( Bailit, JL; Sadananda, GB; Sundaresh, S, 2022) |
| " There were no significant differences in NOWS hospital outcomes between groups in adjusted models: transition to scheduled dosing (methadone 31." | 1.72 | Neonatal Opioid Withdrawal Syndrome: A Comparison of As-Needed Pharmacotherapy. ( Gupta, M; MacMillan, KDL; Melvin, P; Morrison, TM; Murzycki, J; O'Shea, TF; Rothstein, R; Schiff, DM; Singh, R; Van Vleet, MW; Wachman, EM, 2022) |
| "Mothers who screen positive for opioid abuse should be referred to a provider experienced in opioid maintenance therapy." | 1.62 | Neonatal Abstinence Syndrome: Prevention, Recognition, Treatment, and Follow-up. ( Schroeder, M; White, J, 2021) |
| "To determine the prevalence of substance abuse among our pregnant women and the characteristics of their pregnancies, deliveries and new-born infants." | 1.62 | Drug abuse during pregnancy and its neonatal impact. Analysis of the periods 2002-2008 and 2009-2017. ( Guarddon Pueyo, C; López-Vílchez, MÁ; Maya-Enero, S; Mur-Sierra, A, 2021) |
| "Methadone maintenance treatment (MMT) is the most common treatment for opioid-dependent pregnant women worldwide." | 1.62 | Prenatal methadone exposure impairs adolescent cognition and GABAergic neurodevelopment in a novel rat model of maternal methadone treatment. ( Bird, KM; Lum, JS; Millard, SJ; Newell, KA; Pallimulla, S; Wilkie, J; Wright, IM, 2021) |
| "Methadone is an opioid drug commonly prescribed for treating opioid use disorder in pregnant women and was found to accumulate at high levels in the fetal brain of mice, which fell quickly after birth." | 1.62 | Prenatal methadone exposure disrupts behavioral development and alters motor neuron intrinsic properties and local circuitry. ( Allen, MR; Atwood, BK; Baucum, AJ; Engleman, EA; Gao, Y; Grecco, GG; Haggerty, DL; Hoffman, H; Huang, JY; Katner, SN; Kim, J; Lu, HC; Masters, AR; Metzger, CE; Mork, BE; Morris, CW; Newell, EA; Reeves, KC; Sheets, PL; Wu, YC; Yamamoto, BK, 2021) |
| "Women with histories of opioid misuse face drug-related stigma, which can be amplified during pregnancy." | 1.62 | Conceptualizing stigma in contexts of pregnancy and opioid misuse: A qualitative study with women and healthcare providers in Ohio. ( Clapp, J; Howard, H; Madden, D; Spadola, C; Syvertsen, JL; Toneff, H, 2021) |
| " High maternal dosing of buprenorphine is associated with lower BW and HC Z-scores but dose effect is not seen with methadone." | 1.62 | Impact of opioid maintenance treatment during pregnancy on neonatal birth weight and head circumference. ( Adekola, H; Bruder, A; Kumar, N; Masten, M; Monga, R; Moustafa, ASZ; Parmar, K; Rocha, FG; Sampath, V, 2021) |
| "Individuals receiving medications for opioid use disorder after delivery were included in the study." | 1.62 | Methadone and buprenorphine discontinuation among postpartum women with opioid use disorder. ( Bernson, D; Bernstein, J; Bharel, M; Greenfield, SF; Hadland, SE; Hoeppner, BB; Kelly, JF; Nielsen, TC; Reddy, J; Schiff, DM; Taveras, EM; Terplan, M; Wilens, TE, 2021) |
| "Longer duration of medication for opioid use disorder use during pregnancy appears to be associated with improved maternal and perinatal outcomes." | 1.62 | Outcomes associated with the use of medications for opioid use disorder during pregnancy. ( Chen, Q; James, AE; Jarlenski, MP; Kelley, D; Kim, JY; Krans, EE; Rothenberger, SD, 2021) |
| "The increasing prevalence of opioid use disorders among pregnant and postpartum women (PPW) has generated a need for greater availability of specialized programs offering evidence-based and comprehensive substance use disorder treatment services tailored to this population." | 1.56 | Substance use disorder treatment services for pregnant and postpartum women in residential and outpatient settings. ( Ali, MM; Hinde, JM; Meinhofer, A, 2020) |
| "Neonatal abstinence syndrome is an array of signs and symptoms experienced by a newborn due to abrupt discontinuation of intrauterine exposure to certain drugs, primarily opioids." | 1.56 | Screening for Opioid and Stimulant Exposure In Utero Through Targeted and Untargeted Metabolomics Analysis of Umbilical Cords. ( Danell, AS; Forbes, L; Kew, K; Kuehn, D; Mamillapalli, SS; May, L; McIntyre, K; Poppenfuse, S; Ravisankar, S; Rushing, B; Smith-Joyner, A; Strom, C, 2020) |
| "counties, 1,889 (60." | 1.56 | Opioid Use Disorder Treatment Facilities With Programs for Special Populations. ( Alinsky, RH; Cerdá, M; Hadland, SE; Jent, VA; Marshall, BDL; Mauro, PM, 2020) |
| "The methadone group had a lower mean newborn birthweight (2874±459 g) and a greater incidence of low birth weight (11." | 1.56 | Comparison of buprenorphine and methadone in the management of maternal opioid use disorder in full term pregnancies. ( Davis, JA; Garretto, D; Garry, ET; Herrera, KM; Ly, V; Staszewski, CL, 2020) |
| "Medication for opioid use disorder (MOUD) improves both maternal and neonatal outcomes for pregnant women with opioid use disorder (OUD)." | 1.56 | Medications for opioid use disorder in pregnancy in a state women's prison facility. ( Amos, E; Jones, HE; Knittel, AK; Thorp, JM; Zarnick, S, 2020) |
| " In all analyses, methadone and buprenorphine dosing were evaluated as a continuous variable." | 1.56 | Delivery dose of methadone, but not buprenorphine, is associated with the risk and severity of neonatal opiate withdrawal syndrome. ( Bailit, JL; Gibson, KS; Lappen, JR; Stark, S, 2020) |
| "Opioid use during pregnancy is rising, with an estimated 14-22% of women obtaining an opioid prescription during pregnancy." | 1.56 | Factors associated with treatment retention in pregnant women with opioid use disorders prescribed methadone or electing non-pharmacological treatment. ( Haug, NA; Jancaitis, B; Kelpin, S; Masho, S; May, J; Svikis, D, 2020) |
| "Utility of the session, knowledge of PTSD, and barriers of care were evaluated through a pre- and post- session questionnaire." | 1.51 | Integrated Brief Intervention for PTSD and Substance Use in an Antepartum Unit. ( Glance, J; Gopalan, P; Shenai, N, 2019) |
| "Purpose With the rise of opioid use disorder (OUD) among women of childbearing age, effective care models must address the complex needs of pregnant and postpartum women with OUD." | 1.51 | Coordinating Outpatient Care for Pregnant and Postpartum Women with Opioid Use Disorder: Implications from the COACHH Program. ( Connolly, KA; Hodgins, FE; Lang, JM; Malseptic, GG; Melby, LH, 2019) |
| "Perinatal opioid use disorder (OUD) is a life-threatening condition that significantly impacts women in rural areas." | 1.51 | Treating perinatal opioid use disorder in rural settings: Challenges and opportunities. ( Goodman, DJ; Higgins, TM; Meyer, MC, 2019) |
| "Opioid addiction in pregnancy is a growing concern that has recently received a great deal of attention." | 1.48 | Invited Commentary: A Novel Strategy for Addressing Unmeasured Confounding When Comparing Opioid Agonist Therapies in Pregnancy. ( Lemon, LS, 2018) |
| "Preterm birth is associated with less risk of neonatal abstinence syndrome (NAS)." | 1.48 | The Role of Preterm Birth in the Association Between Opioid Maintenance Therapy and Neonatal Abstinence Syndrome. ( Bodnar, LM; Caritis, SN; Lemon, LS; Naimi, A; Platt, RW; Venkataramanan, R, 2018) |
| "Participants were recruited from an opioid dependence treatment center in an urban setting in the Southeastern United States." | 1.48 | Barriers and Facilitators of Breastfeeding Reported by Postpartum Women in Methadone Maintenance Therapy. ( Hicks, J; Morse, E; Wyant, DK, 2018) |
| " With no difference in medical and safety outcomes and a significant reduction in charges, the MAiN model can be considered safe and cost-effective." | 1.48 | Early Treatment Innovation for Opioid-Dependent Newborns: A Retrospective Comparison of Outcomes, Utilization, Quality, and Safety, 2006-2014. ( Charron, E; Chen, L; Dickes, L; Hudson, JA; Mayo, R; Sherrill, WW; Summey, J, 2018) |
| "Buprenorphine or methadone was initiated clinically." | 1.48 | Prenatal Treatment and Outcomes of Women With Opioid Use Disorder. ( Brogly, SB; Hernández-Díaz, S; Regan, E; Saia, KE; Werler, MM, 2018) |
| "Methadone was most frequently used for prenatal opioid dependence; there was little buprenorphine or buprenorphine + naloxone use." | 1.46 | Infants Born to Opioid-Dependent Women in Ontario, 2002-2014. ( Brogly, SB; Davies, G; Dow, K; Johnson, A; Lajkosz, K; Newman, A; Turner, S, 2017) |
| "For methadone, 11 cases were positive in hair, 9 in meconium and 6 in placenta and umbilical cord." | 1.46 | Bioanalysis for cocaine, opiates, methadone, and amphetamines exposure detection during pregnancy. ( Concheiro, M; Concheiro-Guisan, A; Cruz-Landeira, A; de Castro, A; Gónzalez-Colmenero, E; Lendoiro, E; López-Rivadulla, M; Macias-Cortiña, M; Peñas-Silva, P, 2017) |
| " Given the critical role of BCRP in limiting fetal exposure to drugs and xenobiotics, long-term use of these medications may affect fetal drug exposure by altering BCRP expression in human placenta." | 1.46 | Buprenorphine, Norbuprenorphine, R-Methadone, and S-Methadone Upregulate BCRP/ABCG2 Expression by Activating Aryl Hydrocarbon Receptor in Human Placental Trophoblasts. ( Liao, MZ; Mao, Q; Neradugomma, NK, 2017) |
| "Infant delirium is an under-recognized clinical entity in neonatal intensive care, and earlier identification and treatment could minimize morbidities associated with this condition." | 1.46 | A case of infant delirium in the neonatal intensive care unit. ( Bidegain, M; Cotten, CM; Edwards, LE; Hornik, CD; Hutchison, LB; Smith, PB, 2017) |
| "Opioid abuse during pregnancy is associated with fetal growth restriction, placental abruption, preterm labor, fetal death, and Neonatal Abstinence Syndrome." | 1.43 | Simultaneous quantification of buprenorphine, naloxone and phase I and II metabolites in plasma and breastmilk by liquid chromatography-tandem mass spectrometry. ( Barnes, AJ; Huestis, MA; Jansson, LM; Scheidweiler, KB; Swortwood, MJ, 2016) |
| "Findings were inconclusive regarding bacterial vaginosis (± candidiasis) and trichomoniasis." | 1.43 | Evaluation of the vaginal flora in pregnant women receiving opioid maintenance therapy: a matched case-control study. ( Farr, A; Hagmann, M; Holzer, I; Husslein, PW; Kiss, H; Kueronya, V; Petricevic, L, 2016) |
| "Hair specimen is necessary to complement blood and/or urine analyses as it permits differentiation of a single exposure from chronic use of a drug by segmentation of the hair for a stated growth period." | 1.42 | Contribution of in utero drug exposure when interpreting hair results in young children. ( Kintz, P, 2015) |
| "Poly-drug exposed infants and those treated for neonatal abstinence syndrome performed significantly poorer (p=0." | 1.42 | Infants of opioid-dependent mothers: neurodevelopment at six months. ( Mactier, H; McGlone, L, 2015) |
| "Pregnancy is an opportune time to identify opioid dependence, facilitate conversion to opioid maintenance treatment, and coordinate care with specialists in addiction medicine, behavioral health, and social services." | 1.42 | Caring for Opioid-dependent Pregnant Women: Prenatal and Postpartum Care Considerations. ( Bogen, DL; Cochran, G; Krans, EE, 2015) |
| "Opioid addiction is no longer a primarily urban problem." | 1.42 | Caring for pregnant opioid abusers in Vermont: A potential model for non-urban areas. ( Meyer, M; Phillips, J, 2015) |
| "The optimal approach to postpartum dosing among women treated with methadone maintenance is unclear." | 1.40 | Postpartum changes in methadone maintenance dose. ( Cheng, DM; Kaminetzky, LB; Pace, CA; Saia, K; Samet, JH; Walley, AY; Winter, M, 2014) |
| "Methadone treatment was not found to increase the treatment requirement for neonatal abstinence syndrome compared with those using heroin only (P = 0." | 1.39 | Predictors of neonatal outcomes amongst a methadone- and/or heroin-dependent population referred to a multidisciplinary Perinatal and Family Drug Health Service. ( Buckley, V; Haber, P; Razaghi, A, 2013) |
| "The historical and current contexts of opioid use disorders during pregnancy are reviewed." | 1.39 | Treating opioid use disorders during pregnancy: historical, current, and future directions. ( Jones, HE, 2013) |
| "Pregnant women meeting criteria for opioid dependence and attending an integrated care program between 1997 and 2009." | 1.39 | Integrated care for pregnant women on methadone maintenance treatment: Canadian primary care cohort study. ( Abrahams, R; Boyajian, T; Graves, L; Kahan, M; Ordean, A, 2013) |
| "Weight loss was less in small for gestational age compared to appropriately grown infants (p<0." | 1.38 | Postnatal weight loss in substitute methadone-exposed infants: implications for the management of breast feeding. ( Campbell, N; Dryden, C; Mactier, H; Young, D, 2012) |
| "Methadone maintenance treatment (MMT) is the standard treatment of choice for pregnant opiate addicts; however, data on newborn outcomes are contradictory." | 1.38 | Duration of methadone maintenance treatment during pregnancy and pregnancy outcome parameters in women with opiate addiction. ( Adelson, M; Bloch, M; Dollberg, S; Peles, E; Schreiber, S, 2012) |
| "The cohort of women treated for opioid dependence during pregnancy with medication-assisted therapy and delivered at a single institution between 2000 and 2006 were retrospectively identified (n = 149 women; n = 151 neonates)." | 1.38 | Development of a substance abuse program for opioid-dependent nonurban pregnant women improves outcome. ( Benvenuto, A; Howard, D; Johnston, A; Mandell, T; Metayer, J; Meyer, M; Plante, D, 2012) |
| "Neonatal abstinence syndrome is an expected and treatable condition that follows prenatal exposure to opioid agonists." | 1.38 | ACOG Committee Opinion No. 524: Opioid abuse, dependence, and addiction in pregnancy. ( , 2012) |
| "The prevalence of opioid abuse is increasing in North America." | 1.38 | Are infants exposed to methadone in utero at an increased risk for mortality? ( Bridgman-Acker, K; Kelly, LE; Koren, G; Lauwers, A; Madadi, P; Rieder, MJ, 2012) |
| "Pregnancy care for these women needs to continue to develop to improve overall outcomes." | 1.38 | Maternal and neonatal outcomes following methadone substitution during pregnancy. ( Ash, A; Douiri, A; Greig, E, 2012) |
| "Buprenorphine as maintenance treatment of opioid dependence during pregnancy has promise and may offer some benefits, but more research is needed, especially regarding induction of actively addicted women during pregnancy." | 1.38 | Treatment of opioid dependence in the setting of pregnancy. ( Martin, PR; Young, JL, 2012) |
| "Patterns of symptom reports may have clinical implications for maternal and fetal health during pregnancy for OM women including optimization of opioid dosing regimens, education regarding maternal nutritional intake and preventing postnatal depression, thereby ensuring maternal health and fetal development during pregnancy and enhancing mother-infant bonding and healthy child development postnatally." | 1.38 | Patterns of symptom reporting during pregnancy comparing opioid maintained and control women. ( Fisk, A; Gordon, AL; Lopatko, OV; Pearson, V; Stacey, H; White, JM; Woods, A, 2012) |
| "Methadone was readily identified in oral fluid at concentrations greater than 20 ng/mL following daily 30-110 mg/day methadone pharmacotherapy." | 1.37 | Methadone disposition in oral fluid during pharmacotherapy for opioid-dependence. ( Choo, RE; Dams, R; Gray, TR; Huestis, MA; Jones, HE, 2011) |
| "Methadone treatment is a well-recognised cause of QT interval lengthening in adults." | 1.37 | Maternal methadone therapy increases QTc interval in newborn infants. ( Bhoyar, A; Ewer, AK; Holder, G; Hussain, T; Parikh, R, 2011) |
| "R-Methadone concentration was 1." | 1.37 | Estimated infant exposure to enantiomer-specific methadone levels in breastmilk. ( Bogen, DL; Hanusa, BH; Helsel, JC; Perel, JM; Thompson, M; Wisner, KL, 2011) |
| "Methadone was eluted from sweat patches with sodium acetate buffer, followed by solid-phase extraction and quantification by gas chromatography mass spectrometry (limit of quantification > or = 10 ng/patch)." | 1.36 | Excretion of methadone in sweat of pregnant women throughout gestation after controlled methadone administration. ( Barnes, AJ; Brunet, BR; Choo, RE; Huestis, MA; Johnson, RE; Jones, HE; Mura, P, 2010) |
| " Maternal opiate dosing has been investigated with conflicting results." | 1.36 | Perinatal risk factors for the neonatal abstinence syndrome in infants born to women on methadone maintenance therapy. ( Cook, CM; Jones, MP; Liu, AJ; Murray, H; Nanan, R, 2010) |
| "Five methadone clients were interviewed at the clinic and interviews taped for transcription with consent." | 1.36 | A special type of 'hard-to-reach' patient: experiences of pregnant women on methadone. ( Calvin, C; Moriarty, H, 2010) |
| "Both nicotine and cocaine were always retrieved together with their main metabolite." | 1.35 | Nails of newborns in monitoring drug exposure during pregnancy. ( Bertol, E; Mari, F; Politi, L, 2008) |
| "During pregnancy, drug addiction represents one of the most dangerous situations." | 1.35 | Drug addiction during pregnancy: correlations between the placental health and the newborn's outcome - elaboration of a predictive score. ( Boldrini, A; Cuttano, A; Domenici, C; Ghirri, P; Nardini, V; Varese, L, 2009) |
| "They were also offered residential treatment before pregnancy and after the child was born." | 1.35 | Patterns in sleep-wakefulness in three-month old infants exposed to methadone or buprenorphine. ( Bakstad, B; Martinsen, H; Røislien, J; Sarfi, M; Waal, H, 2009) |
| "Methadone treatment is a well recognised cause of QT interval lengthening in adults." | 1.34 | Maternal methadone may cause arrhythmias in neonates. ( Ewer, AK; Hussain, T, 2007) |
| " In addition, methadone dosage requirements were not influenced by CYP2D6 genotypes in these subjects." | 1.34 | Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)- and racemic-methadone. ( Christrup, L; Coller, JK; Foster, DJ; Gillis, D; James, H; Joergensen, C; Somogyi, AA, 2007) |
| "Treatment of maternal opioid dependence with methadone is associated with a delay in fetal heart rate (FHR) accelerations in nonstress tests." | 1.33 | Effect of chronic maternal methadone therapy on intrapartum fetal heart rate patterns. ( Flores, S; McKay, J; Ramirez-Cacho, WA; Rayburn, WF; Schrader, RM, 2006) |
| "Buprenorphine was approved in 1996, and was subject to less restrictive conditions." | 1.33 | Buprenorphine replacement therapy: a confirmed benefit. ( , 2006) |
| "Symptoms of the neonatal withdrawal syndrome are excitation of the central nervous system, the gastrointestinal tract and the respiratory tract." | 1.33 | [A multidisciplinary approach is necessary in the neonatal withdrawal syndrome]. ( Clement-de Boers, A; de Vries, MC; Leeuwenburgh-Pronk, WG, 2006) |
| "Urine samples were analyzed for drug abuse after one month and after one year." | 1.33 | Gender differences and pregnant women in a methadone maintenance treatment (MMT) clinic. ( Adelson, M; Peles, E, 2006) |
| "Methadone was N-demethylated to EDDP by aromatase." | 1.33 | Methadone metabolism by early gestational age placentas. ( Ahmed, MS; Deshmukh, SV; Hankins, GD; Hieronymus, TL; Nanovskaya, TN; Vargas, R, 2006) |
| " This retrospective chart review provides an exploratory examination of newborns treated with either methadone or paregoric for opioid withdrawal and outlines dosage ranges and intervals, side effects, and clinical outcomes of the two regimens." | 1.33 | A chart review comparing paregoric to methadone in the treatment of neonatal opioid withdrawal. ( Wunsch, MJ, 2006) |
| "No miscarriages were observed in the second trimester (n = 54; incidence rate ratio = 0 compared to population norms (95% CI = 0-3." | 1.32 | Is opiate detoxification unsafe in pregnancy? ( Bearn, J; Luty, J; Nikolaou, V, 2003) |
| "The purpose of this study was to determine whether maternal methadone dosage correlates with neonatal withdrawal in a large heroin-addicted pregnant population." | 1.32 | Maternal methadone dose and neonatal withdrawal. ( Berghella, V; Chennat, J; Cherpes, J; Hill, MK; Kaltenbach, K; Lim, PJ, 2003) |
| " Daily supervised dosing by a pharmacist for the first six months resulted in significantly better treatment retention (80% vs 46%) and lower heroin use." | 1.32 | French field experience with buprenorphine. ( Auriacombe, M; Daulouède, JP; Dubernet, J; Fatséas, M; Tignol, J, 2004) |
| "Methadone levels were kept blinded from clinicians." | 1.31 | Methadone trough levels in pregnancy. ( Berghella, V; Drozdick, J; Hill, M; Kaltenbach, K, 2002) |
| "Methadone dosage was also correlated with both duration of neonatal hospitalization and neonatal abstinence score (r(s) =." | 1.31 | Relationship between maternal methadone dosage and neonatal withdrawal. ( Dashe, JS; Jackson, GL; Olscher, DA; Sheffield, JS; Todd, SJ; Wendel, GD, 2002) |
| "Methadone treatment programme for 50 opiate addicts has been conducted at the Department of Clinical Toxicology for a one year." | 1.31 | [Evaluation of health status in participants from a methadone treatment program in Krakow after one year of maintenance treatment]. ( Foryś, Z; Kamenczak, A; Maj, JC; Pach, J, 2001) |
| "Methadone exposed pups were more active and vocalized more when injected with naltrexone than with saline." | 1.30 | Neonatal withdrawal following pre- and postnatal exposure to methadone in the rat. ( Barr, GA; Hamowy, AS; Hutchings, DE; Liu, PY; Wang, S; Zmitrovich, A, 1998) |
| "Women with mild withdrawal symptoms were given clonidine initially, and methadone was substituted if symptoms persisted." | 1.30 | Opioid detoxification in pregnancy. ( Dashe, JS; Jackson, GL; Olscher, DA; Wendel, GD; Zane, EH, 1998) |
| "Traditionally, methadone maintenance therapy has been a once-daily dosing schedule." | 1.30 | Alterations in methadone metabolism during late pregnancy. ( Jarvis, MA; Kniseley, JS; Schnoll, SH; Wu-Pong, S, 1999) |
| "The aim of this study was to assess the influence of maternal methadone dosage on the severity of neonatal withdrawal." | 1.29 | Maternal methadone dosage and neonatal withdrawal. ( Darlow, BA; Horwood, LJ; Lennox, R; Malpas, TJ, 1995) |
| "Methadone was administered in the form of a slow release emulsion to nonpregnant rats and pregnant animals at early, middle, or late gestation." | 1.29 | Methadone levels in plasma, urine, and amniotic fluid of methadone-treated pregnant rats. ( Hope, W; Pierce, TL, 1994) |
| "47 had experienced the AIDS-related deaths of 1 or more family members and 16 of those married were HIV-seropositive." | 1.29 | HIV infection and the meaning of condoms. ( Pivnick, A, 1993) |
| "Higher rates of SIDS were found in infants exposed to opiates alone than in cocaine-exposed infants, but increasing rates of SIDS in cocaine-exposed infants toward the end of the decade suggested that "crack" cocaine may be linked to these increasing rates." | 1.29 | Relationship of maternal substance abuse to subsequent sudden infant death syndrome in offspring. ( Davidson, G; Gaines, J; Habel, L; Jessop, D; Kandall, SR, 1993) |
| " However, cocaine exposed infants did not require more medication for withdrawal management either in terms of dosage or of days treated." | 1.29 | Neonatal withdrawal syndrome in infants exposed to cocaine and methadone. ( Carroll, KM; Mayes, LC, 1996) |
| " The reactivity of the nonstress tests, biophysical profile scores and time needed to complete the biophysical profiled before and after methadone dosing were compared." | 1.29 | Effect of methadone on the biophysical profile. ( Cejtin, HE; Mills, A; Swift, EL, 1996) |
| "Illicit drug abuse, as well as smoking, are known risk factors in the development of intrauterine growth retardation." | 1.28 | [Drug dependence, smoking and fetal growth retardation]. ( Hanzal, E; Hoffmann, G; Kölbl, H, 1992) |
| " Methadone plasma concentration-time data were fit to a one-compartment pharmacokinetic model by extended least-squares regression." | 1.28 | Altered methadone pharmacokinetics in pregnancy: implications for dosing. ( Camara, P; DePetrillo, P; Dudley, M; Griffiths, W; Swift, RM, 1989) |
| "Morphine offspring were significantly different from the controls only in the 120-day-old female group." | 1.27 | Analgesic effect of opiates in offspring of opiate-treated female rats. ( Hovious, JR; Peters, MA, 1984) |
| "Methadone was only one among the risk factors affecting interaction." | 1.27 | A longitudinal study of offspring born to methadone-maintained women. II. Dyadic interaction and infant behavior at 4 months. ( Bernstein, V; Hans, SL; Jeremy, RJ; Marcus, J, 1984) |
| "Methadone was only one among several risk factors affecting interaction." | 1.27 | Dyads at risk: methadone-maintained women and their four-month-old infants. ( Bernstein, VJ; Jeremy, RJ, 1984) |
| "Methadone was found not to be teratogenic to the CD-1 mice." | 1.27 | Developmental toxic effect after subcutaneous injections of methadone in Charles River CD-1 mice. ( Bui, QQ; Sperling, F; West, WL, 1983) |
| "85% of the newborns had withdrawal symptoms and 12% had convulsions the severity of which was not correlated with the type of drug abuse." | 1.27 | Investigation of 89 children born by drug-dependent mothers. I. Neonatal course. ( Andersen, GE; Buckley, W; Friis-Hansen, B; Olofsson, M, 1983) |
| "Naloxone was apparently innocuous in non-dependent neonates." | 1.27 | Postnatal abstinence or acute toxicity can account for morbidity in developmental studies with opiates. ( Lichtblau, L; Sparber, SB, 1983) |
| "There are multiple causes for intrauterine growth retardation but one etiology proposed is maternal drugs." | 1.27 | Maternal drug therapy: effect on fetal and neonatal growth and neurobehavior. ( Hill, RM; Tennyson, LM, 1986) |
| "The increased rate of prematurity, intrauterine growth retardation, and perinatal complications associated with perinatal exposure to cocaine or methamphetamine was greater than that predicted by coexisting risk factors and was consistent with the pharmacologic properties of these drugs." | 1.27 | Perinatal cocaine and methamphetamine exposure: maternal and neonatal correlates. ( Dixon, SD; Oro, AS, 1987) |
| " The same dosage levels of BP and methadone were also given to pseudopregnant rats (PSP) with an induced decidual cell reaction (DCR) in an attempt to distinguish whether adverse effects occur in the maternal or fetal compartment or both." | 1.27 | A comparative study of the reproductive effects of methadone and benzo[a]pyrene in the pregnant and pseudopregnant rat. ( Bui, QQ; Tran, MB; West, WL, 1986) |
| " These data suggest that maternal drug abuse and increased methadone dosage during pregnancy may predispose infants to the development of strabismus." | 1.27 | Occurrence of strabismus in infants born to drug-dependent women. ( Calhoun, JH; Ehrlich, S; Finnegan, LP; Matteucci, T; Nelson, LB, 1987) |
| "in methadone offspring was not different from controls." | 1.27 | Opiate self-administration in adult offspring of methadone-treated female rats. ( Hovious, JR; Peters, MA, 1985) |
| "The use of epidural methadone for postoperative pain relief is advocated, both in view of its analgesic potency and of the low incidence of urinary disturbances." | 1.27 | Urinary function during epidural analgesia with methadone and morphine in post-cesarean section patients. ( Drenger, B; Evron, S; Magora, F; Samueloff, A; Simon, A, 1985) |
| "Methadone was acquired by the perinatal guinea pig both transplacentally and via the milk, more agent being obtained by the former route." | 1.26 | Disposition of maternally-administered methadone and its effects on hepatic drug-metabolizing functions in perinatal guinea pigs. ( Ecobichon, DJ; Pak, RC, 1982) |
| "Methadone binding was determined by use of equilibrium dialysis with (3H)-methadone." | 1.26 | The relationship between maternal and fetal plasma protein binding of methadone in the ewe during the third trimester. ( McFarland, JW; Szeto, HH; Umans, HR; Umans, JG, 1982) |
| "Morphine and methadone were infused at constant rates to the mother and fetus, and steady-state maternal and fetal plasma concentrations of the drugs were determined by radioimmunoassay." | 1.26 | A comparison of morphine and methadone disposition in the maternal-fetal unit. ( McFarland, J; Szeto, HH; Umans, JG, 1982) |
| "Methadone appears to cause deficits in behavioral development which can be detected at weaning." | 1.26 | Methadone exposure in utero: effects on open-field activity in weanling rats. ( Freeman, PR, 1980) |
| "Early withdrawal symptoms persisted for three to four months, and mean growth parameters continued along their respective percentiles." | 1.26 | Early growth patterns of methadone-addicted infants. ( Burns, WJ; Chasnoff, IJ; Hatcher, R, 1980) |
| "This incidence of SIDS was 5." | 1.26 | Sudden unexpected death in infants of narcotic-dependent mothers. ( Falciglia, H; Kandall, SR; Rajegowda, BK, 1978) |
| " Both dose-response and time-duration studies were conducted." | 1.26 | Morphine and methadone-induced antinociception in rats permanently depleted of brain dopamine. ( Elchisak, MA; Harry, GJ; Rosecrans, JA, 1977) |
| "Previous studies have shown that acute administration of methadone to male rats prior to mating results in adverse effects on their progeny, particularly decreased birth weights and increased neonatal mortality." | 1.26 | Chronic methadone administration to male rats: tolerance to adverse effects on sires and their progeny. ( Joffe, JM; Peterson, JM; Smith, SM; Soyka, LF, 1978) |
| " It is suggested that reduction of methadone dosage in late pregnancy results in reduced incidence of withdrawal but must be carefully carried out." | 1.26 | Observation and treatment of neonatal narcotic withdrawal. ( Chappel, JN; Davis, R; Gumpel, J; Madden, JD; Mejia, A; Zuspan, F, 1977) |
| "Body weights were reduced in drug-treated mothers during gestation and the first 2 weeks of lactation." | 1.26 | Effect of chronic maternal methadone exposure on perinatal development. ( McLaughlin, PJ; Zagon, IS, 1977) |
| "The L/S ratios in drug addiction methadone pregnancies and diabetic pregnancies do not have a high degree of correlation with normal L/S ratios after 36 weeks of gestation and are often low." | 1.26 | Amniotic fluid and fetal maturity. ( Singh, EJ; Zuspan, FP, 1976) |
| "Methadone was administered daily to pregnant or nursing rats, or directly to neonates, and the effects on brain and heart weights and ornithine decarboxylase (ODC) activities were determined during postnatal development." | 1.26 | Effects of neonatal or maternal methadone administration on ornithine decarboxylase activity in brain and heart of developing rats. ( Bartolomé, M; Lau, C; Slotkin, TA, 1976) |
| " In the mothers, no significant differences were found with respect to dosage and duration of methadone treatment and years of heroin abuse." | 1.26 | Cytogenetics of methadone-managed and heroin-addicted pregnant women and their newborn infants. ( Amarose, AP; Norusis, MJ, 1976) |
| "Neonatal withdrawal symptoms appear to be related to individual variation in maternal metabolism of the drug, placental transfer of methadone, and most importantly, to the individual variations in the rate of excretion of methadone as reflected in the neonatal plasma t 1/2." | 1.26 | Pharmacologic observations on the neonatal withdrawal syndrome. ( Pippenger, CE; Rosen, TS, 1976) |
| " No significant association was found between maternal dosage of methadone in the last trimester of pregnancy and lentth of gestation, birth weight, or the reported presence of withdrawal symptoms in the neonate." | 1.25 | Results of 313 consecutive live births of infants delivered to patients in the New York City Methadone Maintenance Treatment Program. ( Bashkow, S; Calko, D; Newman, RG, 1975) |
| "The chronic administration of dl-methadone to female rats during gestation results in the simultaneous administration of the drug to the unborn fetus." | 1.25 | Development of a "blood-brain barrier" to methadone in the newborn rat. ( Peters, MA, 1975) |
| "Several cases of chronic unsuspected infections in addicts' infants are reported, raising the question of the significance of undiagnosed infection as it affects growth." | 1.25 | Somatic growth effects of perinatal addiction. ( Wilson, GS, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 365 (35.58) | 18.7374 |
| 1990's | 104 (10.14) | 18.2507 |
| 2000's | 142 (13.84) | 29.6817 |
| 2010's | 296 (28.85) | 24.3611 |
| 2020's | 119 (11.60) | 2.80 |
| Authors | Studies |
|---|---|
| Piske, M | 1 |
| Homayra, F | 1 |
| Min, JE | 1 |
| Zhou, H | 2 |
| Marchand, C | 1 |
| Mead, A | 1 |
| Ng, J | 1 |
| Woolner, M | 1 |
| Nosyk, B | 1 |
| Chan, B | 1 |
| Bougatsos, C | 1 |
| Priest, KC | 1 |
| McCarty, D | 1 |
| Grusing, S | 1 |
| Chou, R | 1 |
| Sujan, A | 1 |
| Cleary, E | 1 |
| Douglas, E | 1 |
| Aujla, R | 1 |
| Boyars, L | 2 |
| Smith, C | 1 |
| Guille, C | 3 |
| Devlin, LA | 2 |
| Young, LW | 1 |
| Kraft, WK | 3 |
| Wachman, EM | 10 |
| Czynski, A | 2 |
| Merhar, SL | 1 |
| Winhusen, T | 5 |
| Jones, HE | 58 |
| Poindexter, BB | 1 |
| Wakschlag, LS | 1 |
| Salisbury, AL | 5 |
| Matthews, AG | 1 |
| Davis, JM | 5 |
| Knypinski, J | 1 |
| Vorawandthanachai, T | 1 |
| Wolfe, DS | 1 |
| Staszewski, C | 1 |
| Herrera, KM | 2 |
| Kertowidjojo, E | 1 |
| Ly, V | 2 |
| Iovino, N | 1 |
| Garretto, D | 2 |
| Kaplan, C | 1 |
| Persad, MD | 1 |
| Garry, DJ | 1 |
| Zhang, P | 1 |
| Tossone, K | 1 |
| Ashmead, R | 1 |
| Bickert, T | 1 |
| Bailey, E | 1 |
| Doogan, NJ | 1 |
| Mack, A | 1 |
| Schmidt, S | 1 |
| Bonny, AE | 1 |
| Schroeder, M | 1 |
| White, J | 2 |
| Chighine, A | 1 |
| Porcu, M | 1 |
| Ferino, G | 1 |
| Lenigno, N | 1 |
| Trignano, C | 1 |
| d'Aloja, E | 1 |
| Locci, E | 1 |
| Frank, CJ | 1 |
| Morrison, L | 1 |
| Abdelwahab, M | 1 |
| Petrich, M | 1 |
| Wang, H | 4 |
| Walker, E | 1 |
| Cleary, EM | 1 |
| Rood, KM | 1 |
| Gonzalez, AM | 1 |
| Arlandson, ME | 1 |
| Patel, A | 1 |
| Premkumar, A | 2 |
| Sundaresh, S | 1 |
| Sadananda, GB | 1 |
| Bailit, JL | 3 |
| Grecco, GG | 5 |
| Haggerty, DL | 2 |
| Reeves, KC | 2 |
| Gao, Y | 4 |
| Maulucci, D | 1 |
| Atwood, BK | 5 |
| Hemmati, Z | 1 |
| Conti, AA | 1 |
| Baldacchino, A | 1 |
| Schiff, DM | 8 |
| Work, EC | 1 |
| Muftu, S | 1 |
| Partridge, S | 1 |
| MacMillan, KDL | 3 |
| Gray, JR | 1 |
| Hoeppner, BB | 3 |
| Kelly, JF | 3 |
| Greenfield, SF | 2 |
| Wilens, TE | 4 |
| Terplan, M | 15 |
| Bernstein, J | 3 |
| Makarious, L | 1 |
| Teng, A | 1 |
| Oei, JL | 1 |
| Morrison, TM | 1 |
| Melvin, P | 1 |
| Singh, R | 1 |
| Murzycki, J | 1 |
| Van Vleet, MW | 1 |
| Rothstein, R | 1 |
| O'Shea, TF | 1 |
| Gupta, M | 1 |
| Jarlenski, M | 1 |
| Chen, Q | 3 |
| Gao, A | 1 |
| Rothenberger, SD | 2 |
| Krans, EE | 7 |
| Gibson, JM | 1 |
| Chu, T | 2 |
| Zeng, W | 1 |
| Wethall, AC | 1 |
| Kong, M | 1 |
| Mellen, N | 2 |
| Devlin Phinney, LA | 1 |
| Cai, J | 2 |
| Tabatabaeepour, N | 1 |
| Morgan, JR | 2 |
| Jalali, A | 1 |
| Kapadia, SN | 1 |
| Meinhofer, A | 3 |
| Nguemeni Tiako, MJ | 2 |
| Friedman, A | 1 |
| South, EC | 1 |
| Epstein, RL | 1 |
| Meisel, ZF | 2 |
| Kinsella, M | 1 |
| Halliday, LOE | 1 |
| Shaw, M | 1 |
| Capel, Y | 1 |
| Nelson, SM | 1 |
| Kearns, RJ | 1 |
| Konijnenberg, C | 9 |
| Melinder, A | 9 |
| Esposito, DB | 1 |
| Huybrechts, KF | 6 |
| Werler, MM | 4 |
| Straub, L | 4 |
| Hernández-Díaz, S | 8 |
| Mogun, H | 5 |
| Bateman, BT | 7 |
| Gamble, ME | 1 |
| Marfatia, R | 1 |
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| Pasman, E | 1 |
| Lee, G | 2 |
| Kollin, R | 1 |
| Rodriguez, B | 1 |
| Agius, E | 1 |
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| Skeer, MR | 1 |
| Stopka, TJ | 1 |
| Shahid, SS | 2 |
| Wu, YC | 3 |
| Nathan, N | 1 |
| Suarez, EA | 4 |
| Connery, HS | 3 |
| Gray, KJ | 3 |
| Lester, B | 4 |
| Cutler, AJ | 2 |
| Cox, DF | 2 |
| Gabrielson, SMB | 2 |
| Picarillo, AP | 2 |
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| Kanervo, MM | 1 |
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| Kahila, HK | 1 |
| Wang, S | 2 |
| Meador, KJ | 1 |
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| Ward, KE | 1 |
| Brothers, TN | 1 |
| Hartzema, A | 2 |
| Quilliam, BJ | 1 |
| Wen, X | 1 |
| Lee, JJ | 2 |
| Saraiya, N | 1 |
| Kuzniewicz, MW | 1 |
| Sanjanwala, AR | 1 |
| Lim, G | 1 |
| McCarthy, JJ | 6 |
| Xu, KY | 1 |
| Martin, CE | 1 |
| Kelly, JC | 1 |
| Carter, EB | 1 |
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| Grucza, RA | 1 |
| Elmore, AL | 1 |
| Patrick, SW | 4 |
| McNeer, E | 1 |
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| Reynolds-Wright, JJ | 1 |
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| Cameron, ST | 1 |
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| Spence, NZ | 2 |
| White, KO | 1 |
| Dwivedi, I | 1 |
| Caldwell, AB | 1 |
| Zhou, D | 2 |
| Wu, W | 3 |
| Subramaniam, S | 1 |
| Haddad, GG | 2 |
| Heller, NA | 2 |
| Logan, BA | 3 |
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| Gibbs, L | 1 |
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| Saia, K | 8 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Fetal Exposure to Cannabinoids: Exposure, Methylation and Neurodevelopmental Effects[NCT04422600] | 72 participants (Actual) | Observational [Patient Registry] | 2020-02-26 | Completed | |||
| Comparison of Buprenorphine vs Buprenorphine/Naloxone on the Effects of Maternal Symptomatology[NCT03740243] | Phase 4 | 0 participants (Actual) | Interventional | 2018-11-30 | Withdrawn (stopped due to No enrollment) | ||
| Maternal Opioid Treatment: Human Experimental Research[NCT00271219] | Phase 3 | 175 participants (Actual) | Interventional | 2005-07-31 | Completed | ||
| A Pilot Randomized Comparative Effectiveness Clinical Trial of Buprenorphine vs. Methadone for the Treatment of Opioid Dependence in Pregnancy.[NCT03098407] | 55 participants (Actual) | Interventional | 2017-04-20 | Completed | |||
| MOms in REcovery (MORE): Defining Optimal Care for Pregnant Women and Infants[NCT04251208] | 444 participants (Actual) | Observational | 2019-07-30 | Active, not recruiting | |||
| Improving Alcohol and Substance Use Care Access, Outcomes, and Equity During the Reproductive Years: A Type 1 Hybrid Trial in Family Planning Clinics[NCT05910580] | 600 participants (Anticipated) | Interventional | 2024-04-01 | Not yet recruiting | |||
| PRevention Of Methamphetamine Use Among Postpartum Women Trial (PROMPT)[NCT05128071] | Early Phase 1 | 40 participants (Anticipated) | Interventional | 2022-02-04 | Recruiting | ||
| Vagal Tone and Neonatal Abstinence Syndrome[NCT00496951] | 65 participants (Actual) | Observational | 2006-09-30 | Completed | |||
| Morphine Versus Methadone for Opiate Exposed Infants With Neonatal Abstinence Syndrome[NCT02851303] | Phase 4 | 61 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| Improving Outcomes in Neonatal Abstinence Syndrome[NCT01958476] | Phase 3 | 117 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| Treating the Partners of Drug Using Pregnant Women: Stage II[NCT00496990] | Phase 2/Phase 3 | 158 participants (Actual) | Interventional | 2005-10-31 | Completed | ||
| Fetal Neurobehavior in Non-methadone Maintained Women in Substance Abuse Treatment[NCT00522626] | 19 participants (Actual) | Observational | 2006-08-31 | Completed | |||
| Methadone, Buprenorphine and Fetal Neurobehavior[NCT00653692] | 29 participants (Actual) | Observational | 2007-05-31 | Completed | |||
| A Prospective Observational Clinical Trial to Compare the Effect of Immediate Postpartum Nexplanon Placement Versus Standard Postpartum Contraceptive Care on Consistent Contraceptive Use and Rapid Repeat Pregnancy in Opioid Dependent Women.[NCT02657148] | 200 participants (Actual) | Observational | 2016-05-31 | Completed | |||
| Safety, Efficacy, Pharmacokinetics, and Pharmacogenomics of Extended-Release Naltrexone in Pregnant Women[NCT03718104] | 100 participants (Anticipated) | Observational | 2018-12-01 | Recruiting | |||
| Single-dose Intraoperative Methadone for Early Ambulation and Sustained Pain Control in Spinal Fusion Surgery Patients[NCT02989597] | Phase 4 | 10 participants (Actual) | Interventional | 2017-07-29 | Terminated (stopped due to Due to personnel loss and logistical issues the study was unable to be completed as planned.) | ||
| The Effects of Opioid Taper on Opioid-Induced Hyperalgesia[NCT03063905] | 15 participants (Actual) | Observational | 2017-01-31 | Terminated (stopped due to funding expired) | |||
| Effect of Continuous Positive Airway Pressure on Fetal pH at Time of Scheduled Cesarean Delivery in Morbidly Obese Women[NCT04993651] | 80 participants (Anticipated) | Interventional | 2021-10-11 | Recruiting | |||
| Methadone, Buprenorphine and Fetal Development[NCT00067184] | 157 participants (Actual) | Observational | 2002-09-30 | Completed | |||
| Influence of Aging on Perioperative Methadone Dosing[NCT04526236] | Phase 4 | 60 participants (Actual) | Interventional | 2019-09-03 | Completed | ||
| Breastfeeding Among Methadone Maintained Women[NCT00218010] | 25 participants (Actual) | Observational | 2000-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00271219)
Timeframe: birth
| Intervention | cm (Mean) |
|---|---|
| A Methadone | 33.0 |
| B Buprenorphine | 33.8 |
(NCT00271219)
Timeframe: delivery until hospital discharge (min=2 days, max=79 days)
| Intervention | days (Mean) |
|---|---|
| A Methadone | 17.5 |
| B Buprenorphine | 10.0 |
NAS was measured with the MOTHER NAS scale, which includes 28 items, 19 of which are used for scoring and medication decisions. Scores can range from 0 to 42, with higher scores indicating more severe withdrawal. (NCT00271219)
Timeframe: minimum twice daily from birth until NAS no longer measured (min=10 days)
| Intervention | Score on the scale (Mean) |
|---|---|
| A Methadone | 12.8 |
| B Buprenorphine | 11.0 |
(NCT00271219)
Timeframe: monthly from study entry until discontinuation or delivery (min=29 days, max=239 days)
| Intervention | percentage of HIV risk behaviors (Number) |
|---|---|
| A Methadone | NA |
| B Buprenorphine | NA |
Pregnant women maintained on an opioid agonist medication may require upward adjustment to their medication during the course of pregnant. The Dose Adequacy Measure represented a recordation of dosing adjustments during the course of the study. (NCT00271219)
Timeframe: from study entry until discontinuation or delivery (min=29 days, max=239 days)
| Intervention | dose increase per trimester (Number) |
|---|---|
| A Methadone | NA |
| B Buprenorphine | NA |
The Addiction Severity Index is a structured clinical interview that assesses problem severity in 7 areas of functioning: alcohol use, drug use, medical, legal, employment, psychosocial, and psychiatric status. Each area of functioning yields a composite scale score between 0 and 1, with higher scores indicating greater problem severity in that area. Only the psychosocial index was examined in this study. (NCT00271219)
Timeframe: at delivery
| Intervention | Score on the scale (Mean) |
|---|---|
| Methadone | .014 |
| Buprenorphine | .088 |
(NCT00271219)
Timeframe: monthly from study entry until discontinuation or delivery (min=29 days, max=239 days)
| Intervention | percentage of drug use (Number) |
|---|---|
| A Methadone | NA |
| B Buprenorphine | NA |
Neonatal abstinence syndrome (NAS) characterized by hyperirritability of the central nervous system and dysfunction in the autonomic nervous system, gastrointestinal tract, and respiratory system.11 When left untreated, NAS can result in serious illness (e.g., diarrhea, feeding difficulties, weight loss, and seizures) and death. (NCT00271219)
Timeframe: From birth until hospital discharge (min=4 days, max=10, depending on site)
| Intervention | participants (Number) |
|---|---|
| A Methadone | 41 |
| B Buprenorphine | 27 |
Total amount in mg (NCT00271219)
Timeframe: Start of NAS treatment until discontinuation of NAS treatment (min=0 days, max=76 days)
| Intervention | mg (Mean) |
|---|---|
| A Methadone | 10.4 |
| B Buprenorphine | 1.1 |
Assessed through chart review of discharge summary documentation of method of infant feeding at time of discharge (NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Morphine | 5 |
| Methadone | 5 |
Number of days in hospital after birth (NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | days (Mean) |
|---|---|
| Morphine | 17.9 |
| Methadone | 16.1 |
(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | days (Mean) |
|---|---|
| Morphine | 14.7 |
| Methadone | 12.8 |
clonidine (NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Morphine | 1 |
| Methadone | 0 |
(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Morphine | 11 |
| Methadone | 6 |
(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Morphine | 0 |
| Methadone | 3 |
(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | morphine equivalents mg (Mean) |
|---|---|
| Morphine | 9.86 |
| Methadone | 33.0 |
Average head circumference growth outcome at 18 month follow-up visit. (NCT01958476)
Timeframe: 18 month follow-up visit
| Intervention | cm (Mean) |
|---|---|
| Methadone | 47.8 |
| Neonatal Morphine Solution | 48.2 |
Average length (cm) at 18 month follow-up visit. (NCT01958476)
Timeframe: 18 month follow-up visit
| Intervention | cm (Mean) |
|---|---|
| Methadone | 82.1 |
| Neonatal Morphine Solution | 81.7 |
Growth outcome weight (lbs) depicted as difference in averaged weights from birth to 18 month follow-up visit. Standard deviations were averaged between birth and 18 mo time points. (NCT01958476)
Timeframe: Birth to 18 month follow-up visit
| Intervention | lbs (Mean) |
|---|---|
| Methadone | 19.1 |
| Neonatal Morphine Solution | 18.7 |
Participants were monitored for the duration of their hospitalization, an expected mean of 22 days. (NCT01958476)
Timeframe: Participants will be monitored during their entire hospitalization, expected mean 22 days.
| Intervention | days (Mean) |
|---|---|
| Methadone | 21.8 |
| Neonatal Morphine Solution | 23.2 |
Participants were monitored for the duration of their hospitalization attributable to NAS only. (NCT01958476)
Timeframe: Participants were monitored for the duration of their hospitalization, expected mean 22 days.
| Intervention | days (Mean) |
|---|---|
| Methadone | 18.9 |
| Neonatal Morphine Solution | 21.1 |
Total number of days infant treated with replacement opioids while admitted to the hospital. (NCT01958476)
Timeframe: Participants were monitored for the duration of their hospitalization.
| Intervention | days (Mean) |
|---|---|
| Methadone | 14.7 |
| Neonatal Morphine Solution | 16.6 |
"One Finnegan score ≥12, or two consecutive scores ≥8 affirms the requirement for pharmacological treatment or increasing treatment dosage. If the infant continued to have two consecutive Finnegan Scores ≥8 two times consecutively, or one ≥12, the dose was increased to the next level. (Level I: 0.3 mg/kg/day) (Level II: 0.5 mg/kg/day) (Level III: 0.7 mg/kg/day)~A higher Finnegan score indicates greater severity of NAS (min 0, max 50)." (NCT01958476)
Timeframe: Participants were monitored for the duration of their hospitalization, an average of 22 days.
| Intervention | Participants (Count of Participants) |
|---|---|
| Methadone | 22 |
| Neonatal Morphine Solution | 28 |
Number of infants treated with a second medication following protocol, phenobarbital. If the Finnegan Score remained elevated (still scored ≥8 two times consecutively, or still scored once ≥12) despite increasing to a predetermined maximal opioid dose (methadone or morphine), phenobarbital was administered (20-mg/kg loading dose followed by 4-5 mg/kg daily). (NCT01958476)
Timeframe: Participants were monitored for the duration of their hospitalization, an average of 22 days.
| Intervention | Participants (Count of Participants) |
|---|---|
| Methadone | 10 |
| Neonatal Morphine Solution | 17 |
The Bayley Scales of Infant and Toddler Development (BSID-III) assesses the development of infants and children (1-42 months) through a series of developmental play tasks, identifying children with developmental delay. Raw scores of completed items are summarized within three distinct scale scores (Cognitive Scale, Language Scale, Motor Scale). Scale scores are each converted to composite scores to determine the child's performance compared with scores of age-matched children of typical development (percentile rank). A higher composite score indicates more ideal developmental outcome (range 40-160). At 18 month follow-up visit, participants were assessed using the BSID-III for cognitive, language and motor scale composite score outcomes. (NCT01958476)
Timeframe: Assessment at 18 month follow-up visit
| Intervention | scores on a scale (Composite) (Mean) | ||
|---|---|---|---|
| Cognitive Composite | Language Composite | Motor Composite | |
| Methadone | 100.1 | 96.0 | 103.6 |
| Neonatal Morphine Solution | 98.1 | 94.2 | 99.1 |
Fetal heart rate in beats per minute (NCT00522626)
Timeframe: 60 minutes
| Intervention | beats per minute (Mean) |
|---|---|
| Trough Fetal Heart Rate | 142.34 |
133 reviews available for methadone and Pregnancy
| Article | Year |
|---|---|
Opioid treatment programs, telemedicine and COVID-19: A scoping review.
Topics: Analgesics, Opioid; Buprenorphine; COVID-19 Drug Treatment; Female; Humans; Methadone; Opiate Substi | 2022 |
Neonatal opioid withdrawal syndrome: a review of the science and a look toward the use of buprenorphine for affected infants.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant; Infant, Newborn; Methadone; Neonatal Abst | 2022 |
Ophthalmic outcomes in children exposed to opioid maintenance treatment in utero: A systematic review and meta-analysis.
Topics: Analgesics, Opioid; Buprenorphine; Child; Female; Humans; Infant; Methadone; Opiate Substitution Tre | 2022 |
SIDS is associated with prenatal drug use: a meta-analysis and systematic review of 4 238 685 infants.
Topics: Analgesics, Opioid; Cocaine; Female; Humans; Infant; Methadone; Observational Studies as Topic; Preg | 2022 |
Buprenorphine Compared with Methadone in Pregnancy: A Systematic Review and Meta-Analysis.
Topics: Analgesics, Opioid; Buprenorphine; Child; Female; Humans; Infant, Newborn; Methadone; Opiate Substit | 2022 |
Opioid Use Disorder in Pregnant Patients.
Topics: Analgesics, Opioid; Anesthetics; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treat | 2022 |
Prenatal Opioid Exposure and Neurodevelopmental Outcomes.
Topics: Analgesics, Opioid; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Methadone; Neonatal A | 2023 |
Opioids and Opioid Use Disorder in Pregnancy.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid- | 2023 |
Harmful effects of opioid use in pregnancy: A scientific review commissioned by the European Board and College of obstetrics and gynaecology (EBCOG).
Topics: Analgesics, Opioid; Buprenorphine; Female; Gynecology; Humans; Infant; Methadone; Obstetrics; Opiate | 2023 |
Monitoring Prenatal Exposure to Buprenorphine and Methadone.
Topics: Analgesics, Opioid; Buprenorphine; Drug Monitoring; Female; Hair; Humans; Meconium; Methadone; Opiat | 2020 |
Opioid Use Disorder: Medical Treatment Options.
Topics: Analgesics, Opioid; Buprenorphine; Chronic Disease; Evidence-Based Medicine; Female; Humans; Male; M | 2019 |
Neonatal Abstinence Syndrome: Review of Epidemiology, Care Models, and Current Understanding of Outcomes.
Topics: Analgesics, Opioid; Breast Feeding; Buprenorphine; Female; Humans; Hypnotics and Sedatives; Infant, | 2019 |
Opioid Use in Pregnancy.
Topics: Buprenorphine; Child Development; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Sy | 2019 |
Prenatal exposure to methadone or buprenorphine and long-term outcomes: A meta-analysis.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Child; Female; Humans; Infant, Newborn; Male; Methadone; | 2020 |
Cognitive Outcomes of Young Children After Prenatal Exposure to Medications for Opioid Use Disorder: A Systematic Review and Meta-analysis.
Topics: Analgesics, Opioid; Buprenorphine; Child Development; Child, Preschool; Cognition; Cognitive Dysfunc | 2020 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Opioid Management in Pregnancy and Postpartum.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Cesarean Section; Female; Humans; Infant, Newborn; Labor, | 2020 |
Changing Outdated Methadone Regulations That Harm Pregnant Patients.
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Health Policy; Humans; Methadone; Opia | 2021 |
Maintenance agonist treatments for opiate-dependent pregnant women.
Topics: Birth Weight; Buprenorphine; Delayed-Action Preparations; Female; Humans; Infant; Infant, Newborn; M | 2020 |
Use of Medications for Treatment of Opioid Use Disorder Among US Medicaid Enrollees in 11 States, 2014-2018.
Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Child; Cross-Sectional Studies; Female; Humans | 2021 |
Peripartum Anesthetic Management of the Opioid-tolerant or Buprenorphine/Suboxone-dependent Patient.
Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Female; Humans; Methado | 2017 |
Neonatal Abstinence Syndrome: Update on Diagnostic and Therapeutic Strategies.
Topics: Analgesics, Opioid; Antidepressive Agents; Buprenorphine; Female; Humans; Infant, Newborn; Methadone | 2017 |
A Retrospective Cohort Study of Obstetric Outcomes in Opioid-Dependent Women Treated with Implant Naltrexone, Oral Methadone or Sublingual Buprenorphine, and Non-Dependent Controls.
Topics: Administration, Oral; Administration, Sublingual; Buprenorphine; Drug Implants; Female; Humans; Meth | 2017 |
Methadone, Buprenorphine, and Naltrexone for the Treatment of Opioid Use Disorder in Pregnant Women.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naltrexone; | 2017 |
Maternal Use of Opioids During Pregnancy and Congenital Malformations: A Systematic Review.
Topics: Abnormalities, Drug-Induced; Analgesics, Opioid; Female; Humans; Methadone; Morphine Derivatives; Op | 2017 |
Treatment of Perinatal Opioid Use Disorder.
Topics: Adult; Analgesics, Opioid; Decision Making; Female; Humans; Infant, Newborn; Methadone; Neonatal Abs | 2018 |
Opioid Detoxification in Pregnancy: Systematic Review and Meta-Analysis of Perinatal Outcomes.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence S | 2019 |
Neonatal abstinence syndrome.
Topics: Adult; Female; Humans; Infant; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Opiate Subs | 2018 |
Childhood neurodevelopment after prescription of maintenance methadone for opioid dependency in pregnancy: a systematic review and meta-analysis.
Topics: Child; Child Development; Child, Preschool; Female; Humans; Infant; Methadone; Narcotics; Opioid-Rel | 2019 |
Morphine and Methadone for Neonatal Abstinence Syndrome: A Systematic Review.
Topics: Analgesics, Opioid; Female; Humans; Infant; Infant, Newborn; Length of Stay; Male; Methadone; Morphi | 2018 |
Opioid use disorder during pregnancy: An overview.
Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Cognitive Behavioral Therapy; Female; Fetal Di | 2019 |
Pharmacological treatment of opioid use disorder in pregnancy.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Guidelines as Topic; Humans; Methadone; Narcotic A | 2019 |
Post-cesarean delivery pain. Management of the opioid-dependent patient before, during and after cesarean delivery.
Topics: Analgesia, Patient-Controlled; Buprenorphine; Cesarean Section; Female; Humans; Methadone; Naltrexon | 2019 |
Analgesia, Opioids, and Other Drug Use During Pregnancy and Neonatal Abstinence Syndrome.
Topics: Analgesia, Obstetrical; Analgesics; Analgesics, Opioid; Breast Feeding; Buprenorphine; Buprenorphine | 2019 |
Management and monitoring of opioid use in pregnancy.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Maternal-Fetal Exchange; Methadone; Narcot | 2020 |
Consideration of opioid agonist treatment in a pregnant adolescent: A case report and literature review.
Topics: Adolescent; Ambulatory Care; Analgesics, Opioid; Buprenorphine; Child, Foster; Female; Humans; Lost | 2020 |
Chronic opioid use during pregnancy: maternal and fetal implications.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence S | 2013 |
Managing opioid dependence in pregnancy -- a general practice perspective.
Topics: Adult; Buprenorphine; Female; General Practice; Humans; Methadone; Narcotics; Neonatal Abstinence Sy | 2013 |
Medication-assisted treatment with methadone: assessing the evidence.
Topics: Analgesics, Opioid; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorde | 2014 |
Maintenance agonist treatments for opiate-dependent pregnant women.
Topics: Birth Weight; Buprenorphine; Delayed-Action Preparations; Female; Humans; Infant; Infant, Newborn; M | 2013 |
Behavioral effects of perinatal opioid exposure.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Female; Humans; Illicit Drugs; Infant, Ne | 2014 |
Buprenorphine and methadone for opioid addiction during pregnancy.
Topics: Analgesics, Opioid; Buprenorphine; Drug Administration Schedule; Female; Humans; Methadone; Neonatal | 2014 |
Neonatal opioid withdrawal syndrome.
Topics: Analgesics, Opioid; Breast Feeding; Buprenorphine; Female; Humans; Infant, Newborn; Male; Methadone; | 2014 |
Neonatal abstinence syndrome.
Topics: Animals; Breast Feeding; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; O | 2014 |
Prenatal buprenorphine versus methadone exposure and neonatal outcomes: systematic review and meta-analysis.
Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Models, Statistical; Neonatal Abstinence | 2014 |
Review of the assessment and management of neonatal abstinence syndrome.
Topics: Breast Feeding; Buprenorphine; Clonidine; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neo | 2014 |
Treating tobacco use disorder in pregnant women in medication-assisted treatment for an opioid use disorder: a systematic review.
Topics: Analgesics, Opioid; Behavior Therapy; Buprenorphine; Female; Humans; Methadone; Opiate Substitution | 2015 |
Medication assisted treatment discontinuation in pregnant and postpartum women with opioid use disorder.
Topics: Buprenorphine; Female; Humans; Kaplan-Meier Estimate; Methadone; Narcotic Antagonists; Narcotics; Op | 2015 |
Question: is breastfeeding useful in the management of neonatal abstinence syndrome?
Topics: Breast Feeding; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinence Syndrome; | 2015 |
Pharmacological Management of Opioid Use Disorder in Pregnant Women.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Opiate Subst | 2015 |
New Pain Management Options for the Surgical Patient on Methadone and Buprenorphine.
Topics: Buprenorphine; Drug Administration Schedule; Female; Humans; Methadone; Neonatal Abstinence Syndrome | 2016 |
Buprenorphine Versus Methadone for Opioid Dependence in Pregnancy.
Topics: Buprenorphine; Female; Humans; Infant; Infant, Newborn; Length of Stay; Methadone; Neonatal Abstinen | 2016 |
Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child.
Topics: Abnormalities, Drug-Induced; Analgesics, Opioid; Birth Weight; Buprenorphine; Female; Fetal Death; F | 2016 |
Long-Term Outcomes of Infants with Neonatal Abstinence Syndrome.
Topics: Analgesics, Opioid; Child Abuse; Epigenesis, Genetic; Female; Humans; Infant, Newborn; Methadone; Ne | 2016 |
Opioid dependence and pregnancy: minimizing stress on the fetal brain.
Topics: Brain Diseases; Buprenorphine; Female; Fetal Diseases; Humans; Methadone; Opioid-Related Disorders; | 2017 |
Neonatal Abstinence Syndrome.
Topics: Female; Humans; Incidence; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome; Opiat | 2016 |
Pregnancy and injecting drug use.
Topics: Female; Humans; Methadone; Narcotics; Opioid-Related Disorders; Patient Care Planning; Pregnancy; Pr | 2008 |
Treating pregnant women dependent on opioids is not the same as treating pregnancy and opioid dependence: a knowledge synthesis for better treatment for women and neonates.
Topics: Buprenorphine; Diagnosis, Dual (Psychiatry); Female; GABA Modulators; Humans; Infant, Newborn; Menta | 2008 |
Methadone exposure during lactation.
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Humans; Lactation; Maternal Exposure; | 2008 |
[Methadone treatment and its dangers].
Topics: Adult; Analgesics, Opioid; Child, Preschool; Drug Interactions; Drug Overdose; Electrocardiography; | 2009 |
[Utility of atazanavir in special populations].
Topics: Adolescent; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Cardi | 2008 |
Prenatal drug exposure: infant and toddler outcomes.
Topics: Buprenorphine; Child Development; Child, Preschool; Cocaine; Cocaine-Related Disorders; Female; Hero | 2010 |
The management of heroin misuse in pregnancy: time for a rethink?
Topics: Buprenorphine; Child, Preschool; Developmental Disabilities; Female; Heroin Dependence; Humans; Infa | 2011 |
Methadone dose and neonatal abstinence syndrome-systematic review and meta-analysis.
Topics: Cohort Studies; Databases, Bibliographic; Dose-Response Relationship, Drug; Female; Humans; Infant, | 2010 |
Drug interactions associated with methadone, buprenorphine, cocaine, and HIV medications: implications for pregnant women.
Topics: Anti-HIV Agents; Buprenorphine; Cocaine; Drug Interactions; Female; HIV Infections; Humans; Methadon | 2011 |
Prenatal exposure to methadone and buprenorphine: a review of the potential effects on cognitive development.
Topics: Analgesics, Opioid; Buprenorphine; Child; Child Development; Cognition; Female; Humans; Male; Methad | 2011 |
Intrauterine abstinence syndrome (IAS) during buprenorphine inductions and methadone tapers: can we assure the safety of the fetus?
Topics: Buprenorphine; Epigenesis, Genetic; Female; Fetal Diseases; Humans; Methadone; Narcotics; Pregnancy; | 2012 |
Update on the pharmacologic management of neonatal abstinence syndrome.
Topics: Benzodiazepines; Buprenorphine; Clonidine; Female; Humans; Hypnotics and Sedatives; Infant, Newborn; | 2011 |
[Breast feeding during methadon- and buprenorphin therapy].
Topics: Analgesics, Opioid; Breast Feeding; Buprenorphine; Contraindications; Dose-Response Relationship, Dr | 2011 |
[Pregnant opioid addicted patients and additional drug intake. Part I. Toxic effects and therapeutic consequences].
Topics: Adult; Alcoholism; Central Nervous System Stimulants; Drug Monitoring; Female; Heroin Dependence; Hu | 2011 |
Management of opioid substitution therapy during medical intervention.
Topics: Analgesics; Australia; Buprenorphine; Comorbidity; Drug Interactions; Female; Humans; Liver Diseases | 2012 |
Naltrexone in the treatment of opioid-dependent pregnant women: the case for a considered and measured approach to research.
Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naltrexone; Narcotic Antagonists; Narcoti | 2013 |
Methadone and buprenorphine for the management of opioid dependence in pregnancy.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence S | 2012 |
Novel pharmacotherapeutic strategies for treatment of opioid-induced neonatal abstinence syndrome.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Immunotherapy; Infant, Newborn; Methadone; Neonat | 2013 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Neonatal abstinence syndrome: therapeutic interventions.
Topics: Female; Humans; Infant; Infant Welfare; Infant, Newborn; Male; Methadone; Morphine; Narcotics; Neona | 2013 |
Opioid addiction in pregnancy.
Topics: Analgesics, Opioid; Breast Feeding; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neona | 2012 |
Pharmacologic management of neonatal abstinence syndrome in a community hospital.
Topics: Analgesics, Opioid; Female; Florida; Humans; Infant, Newborn; Intensive Care, Neonatal; Length of St | 2013 |
Neonatal abstinence syndrome: treatment and pediatric outcomes.
Topics: Developmental Disabilities; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinen | 2013 |
The effect of abused substances on antenatal and intrapartum fetal testing and well-being.
Topics: Alcohol Drinking; Biophysical Phenomena; Blood Flow Velocity; Cocaine; Female; Fetal Movement; Heart | 2013 |
Chronic and acute pain and pain management for patients in methadone maintenance treatment.
Topics: Acute Pain; Analgesics; Catastrophization; Chronic Pain; Drug Tolerance; Female; Humans; Methadone; | 2013 |
[Is buprenorphine a potential alternative to methadone for treating pregnant drug users? Inventory of clinical data in the literature].
Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Narcotic Antagonists; Narcotics; Neonatal | 2002 |
Pharmacotherapy for pregnant women with addictions.
Topics: Adolescent; Adult; Behavior, Addictive; Cocaine-Related Disorders; Female; Follow-Up Studies; Gestat | 2004 |
[Therapeutic strategies for opioid addiction: the role of substitution therapy].
Topics: Buprenorphine; Female; Humans; Mental Disorders; Methadone; Narcotic Antagonists; Narcotics; Opioid- | 2004 |
Pharmacokinetics of methadone.
Topics: Aged; Analgesics, Opioid; Area Under Curve; Biological Availability; Child; Cytochrome P-450 Enzyme | 2005 |
Pharmacokinetics of methadone.
Topics: Aged; Analgesics, Opioid; Area Under Curve; Biological Availability; Child; Cytochrome P-450 Enzyme | 2005 |
Pharmacokinetics of methadone.
Topics: Aged; Analgesics, Opioid; Area Under Curve; Biological Availability; Child; Cytochrome P-450 Enzyme | 2005 |
Pharmacokinetics of methadone.
Topics: Aged; Analgesics, Opioid; Area Under Curve; Biological Availability; Child; Cytochrome P-450 Enzyme | 2005 |
Methadone and buprenorphine treatment during pregnancy: what are the effects on infants?
Topics: Analgesics, Opioid; Buprenorphine; Female; Fetus; Humans; Infant, Low Birth Weight; Infant, Newborn; | 2007 |
Treatment of opioid-dependent pregnant women: clinical and research issues.
Topics: Analgesics, Opioid; Buprenorphine; Clinical Trials as Topic; Decision Making; Female; Humans; Infant | 2008 |
Opioid dependence and pregnancy.
Topics: Buprenorphine; Female; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy | 2008 |
Maintenance agonist treatments for opiate dependent pregnant women.
Topics: Birth Weight; Buprenorphine; Female; Humans; Infant; Infant, Newborn; Methadone; Narcotics; Opioid-R | 2008 |
Effects of perinatal exposure to methadone on development of neurotransmission: biochemical bases for behavioral alterations.
Topics: Animals; Behavior, Animal; Brain; Female; Methadone; Nervous System; Neurotransmitter Agents; Norepi | 1983 |
Behavioral effects of prenatal exposure to opiates.
Topics: Age Factors; Animals; Animals, Suckling; Behavior, Animal; Female; Heroin; Humans; Methadone; Mice; | 1983 |
Infants of drug-dependent mothers.
Topics: Abnormalities, Drug-Induced; Female; Fetal Alcohol Spectrum Disorders; Fetal Growth Retardation; Her | 1983 |
Rifampin drug interactions.
Topics: Anticoagulants; Barbiturates; Contraceptives, Oral; Cytochrome P-450 Enzyme System; Digitoxin; Drug | 1984 |
Male mediated drug effects on offspring.
Topics: Animals; Birth Weight; Fathers; Female; Humans; Litter Size; Male; Methadone; Morphine; Pregnancy; R | 1980 |
The consequences of prenatal substance use for the developing fetus, newborn, and young child.
Topics: Cannabis; Child; Child, Preschool; Congenital Abnormalities; Developmental Disabilities; Female; Hea | 1993 |
Effects of in-utero opiate exposure: new paradigms for old questions.
Topics: Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related | 1994 |
A new look at some old mechanisms in human newborns: taste and tactile determinants of state, affect, and action.
Topics: Affect; Crying; Female; Heart Rate; Humans; Infant Care; Infant, Newborn; Male; Methadone; Mother-Ch | 1994 |
Bridging species: a new look and new questions.
Topics: Female; Humans; Infant Care; Infant, Newborn; Male; Methadone; Mother-Child Relations; Mothers; Preg | 1994 |
Methadone during pregnancy: the search for a valid animal model.
Topics: Animals; Behavior, Animal; Child; Child, Preschool; Disease Models, Animal; Female; Heroin Dependenc | 1993 |
Prenatal diagnosis of amniotic band syndrome in a methadone user: review of the literature and a case report.
Topics: Adult; Amniotic Band Syndrome; Female; Fetal Diseases; Forearm; Gestational Age; Humans; Infant, New | 1996 |
Pharmacotherapy for opioid and cocaine abuse.
Topics: Antidepressive Agents; Cocaine; Dopamine Agonists; Female; Humans; Methadone; Narcotic Antagonists; | 1997 |
Helping patients who misuse drugs.
Topics: Central Nervous System Depressants; Family Practice; Female; Humans; Methadone; Narcotics; Opioid-Re | 1997 |
The relationship between maternal use of heroin and methadone and infant birth weight.
Topics: Birth Weight; Female; Heroin; Humans; Infant, Low Birth Weight; Infant, Newborn; Methadone; Opioid-R | 1997 |
Opioid dependence during pregnancy. Effects and management.
Topics: Delivery, Obstetric; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinence Synd | 1998 |
Assessing the relationship between maternal opiate use and neonatal mortality.
Topics: Female; Heroin; Humans; Infant Mortality; Infant, Newborn; Methadone; Narcotics; Opioid-Related Diso | 1998 |
Neonatal drug addiction.
Topics: Female; Heroin; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinence Syndrome; Pregnan | 1998 |
Methadone in the management of narcotic addiction in pregnancy.
Topics: Female; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy; Pregnancy Complications | 1998 |
[Substitution therapy of drug addicts].
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Pregnancy; Pregnancy Complications; Pr | 1998 |
Early development of infants exposed to drugs prenatally.
Topics: Alcoholism; Child Abuse; Child Development; Child, Preschool; Cocaine; Cocaine-Related Disorders; Et | 1999 |
The methadone-maintained pregnancy.
Topics: Comprehensive Health Care; Delivery, Obstetric; Embryonic and Fetal Development; Family Health; Fema | 1999 |
[Preventing HIV infection: an exercise in evaluating scientific evidence in public health].
Topics: Adult; Anti-HIV Agents; Biological Products; Clinical Trials as Topic; Evidence-Based Medicine; Fema | 1999 |
[Special problems of HIV-positive women who are either drug abusers or on methadone replacement therapy].
Topics: Cocaine; Drug Administration Schedule; Female; Germany; Heroin; HIV Infections; HIV Protease Inhibit | 1999 |
[Pregnancy and drug abuse: current situation and therapeutic strategies].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Female; Fetal Growth Retardation; Hepatit | 2000 |
Treatment of neonatal abstinence syndrome with breast milk containing methadone.
Topics: Breast Feeding; Drug Administration Schedule; Female; Humans; Infant, Newborn; Labor, Obstetric; Met | 2002 |
Clinical management of methadone dependence during pregnancy.
Topics: Female; Fetus; Humans; Infant, Newborn; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Co | 2001 |
Effects of narcotics on the reproductive system.
Topics: Adrenal Cortex; Animals; Corticosterone; Cortisone; Cyclic AMP; Female; Follicle Stimulating Hormone | 1977 |
The effect of maternal narcotic addiction on the newborn infant.
Topics: Abnormalities, Drug-Induced; Breast Feeding; Female; Fertility; Heroin Dependence; Humans; Infant Mo | 1977 |
Drugs and chemicals associated with intrauterine growth deficiency.
Topics: Abnormalities, Drug-Induced; Adult; Aminopterin; Animals; Disease Models, Animal; Ethanol; Female; F | 1978 |
Toxicology of LAAM.
Topics: Animals; Behavior, Animal; Body Weight; Dogs; Dose-Response Relationship, Drug; Drinking; Drug Admin | 1976 |
[The pharmacology of drugs (heroin, L-methadone, cocaine, hashish) and their effects on pregnancy, fetus and neonate].
Topics: Abnormalities, Drug-Induced; Amphetamine; Cannabinoids; Cocaine; Female; Fetus; Heroin; Humans; Infa | 1991 |
[Findings in newborn infants following drug abuse or drug weaning in the mother].
Topics: Abnormalities, Drug-Induced; Adult; Female; Fetal Growth Retardation; Heroin Dependence; Humans; Inf | 1991 |
[Drug abuse, pregnancy and HIV infection].
Topics: Adult; AIDS Serodiagnosis; Contraception Behavior; Female; HIV Infections; Humans; Methadone; Opport | 1991 |
Narcotic use in pregnancy.
Topics: Female; Humans; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Complications; Prevalence; | 1991 |
Methadone maintenance in the treatment of opioid dependence. A current perspective.
Topics: Acquired Immunodeficiency Syndrome; Attitude of Health Personnel; Cocaine; Drug Interactions; Ethano | 1990 |
Behavior and development patterns in children born to heroin-addicted and methadone-addicted mothers.
Topics: Child; Child Behavior Disorders; Child, Preschool; Developmental Disabilities; Female; Heroin; Human | 1988 |
Perinatal exposure to methadone: how do early biochemical alterations cause neurofunctional disturbances?
Topics: Adrenergic Fibers; Animals; Brain; Catecholamines; Female; Methadone; Pregnancy; Prenatal Exposure D | 1988 |
Plasma drug binding: implications for anesthesiologists.
Topics: Age Factors; Alfentanil; Alprenolol; Anesthesia; Anesthetics; Blood Proteins; Bupivacaine; Burns; Ca | 1986 |
Treatment perspectives in drug misuse: the opiate paradigm.
Topics: Endorphins; Female; History, 18th Century; History, 19th Century; History, 20th Century; Humans; Mal | 1987 |
Developmental effects of narcotics.
Topics: Analysis of Variance; Animals; Body Weight; Female; Fetal Diseases; Growth; Humans; Methadone; Nalox | 1986 |
The drug user as a parent.
Topics: Child Development; Child Rearing; Child, Preschool; Curriculum; Female; Humans; Infant; Infant, Newb | 1985 |
Maternal and neonatal metabolism of analgesic drugs.
Topics: Administration, Oral; Amniotic Fluid; Amphetamine; Analgesics; Biological Transport; Blood; Chlorpro | 1973 |
Methadone.
Topics: Acetates; Administration, Oral; Adolescent; American Medical Association; Canada; Chemical Phenomena | 1973 |
Narcotic poisoning of children (1) through accidental ingestion of methadone and (2) in utero.
Topics: Administration, Oral; Apgar Score; Birth Weight; Child; Child Care; Female; Gestational Age; Heroin | 1974 |
60 trials available for methadone and Pregnancy
| Article | Year |
|---|---|
Pragmatic, randomized, blinded trial to shorten pharmacologic treatment of newborns with neonatal opioid withdrawal syndrome (NOWS).
Topics: Analgesics, Opioid; Family; Female; Humans; Infant, Newborn; Methadone; Morphine; Neonatal Abstinenc | 2023 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Neonatal Abstinence Syndrome Severity Index Predicts 18-Month Neurodevelopmental Outcome in Neonates Randomized to Morphine or Methadone.
Topics: Analgesics, Opioid; Cluster Analysis; Female; Humans; Infant; Infant, Newborn; Length of Stay; Male; | 2020 |
Precision dosing of methadone during pregnancy: A pharmacokinetics virtual clinical trials study.
Topics: Female; Humans; Methadone; Opioid-Related Disorders; Pregnancy | 2021 |
Randomized Clinical Trial of Standard- Versus High-Calorie Formula for Methadone-Exposed Infants: A Feasibility Study.
Topics: Double-Blind Method; Energy Intake; Feasibility Studies; Female; Humans; Infant Formula; Infant, New | 2018 |
Prenatal exposure to methadone or buprenorphine: Early childhood developmental outcomes.
Topics: Adult; Buprenorphine; Child Development; Child, Preschool; Cognition; Female; Humans; Infant, Newbor | 2018 |
Evaluation of methadone concentrations in bitches and in umbilical cords after epidural or systemic administration for caesarean section: A randomized trial.
Topics: Analgesics, Opioid; Anesthesia; Anesthesia, Epidural; Animals; Cesarean Section; Dogs; Female; Injec | 2019 |
Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention.
Topics: Adult; Analysis of Variance; Buprenorphine; Confidence Intervals; Diagnostic and Statistical Manual | 2013 |
Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention.
Topics: Adult; Analysis of Variance; Buprenorphine; Confidence Intervals; Diagnostic and Statistical Manual | 2013 |
Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention.
Topics: Adult; Analysis of Variance; Buprenorphine; Confidence Intervals; Diagnostic and Statistical Manual | 2013 |
Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention.
Topics: Adult; Analysis of Variance; Buprenorphine; Confidence Intervals; Diagnostic and Statistical Manual | 2013 |
Nonserious adverse events in randomized trials with opioid-dependent pregnant women: direct versus indirect measurement.
Topics: Analgesics, Opioid; Buprenorphine; Data Collection; Double-Blind Method; Female; Humans; Infant, New | 2012 |
Design considerations for point-of-care clinical trials comparing methadone and buprenorphine treatment for opioid dependence in pregnancy and for neonatal abstinence syndrome.
Topics: Adult; Birth Weight; Buprenorphine; Female; Humans; Infant, Newborn; Length of Stay; Methadone; Neon | 2014 |
The effect of prenatal alcohol co-exposure on neonatal abstinence syndrome in infants born to mothers in opioid maintenance treatment.
Topics: Adult; Alcohol Drinking; Female; Humans; Incidence; Infant, Newborn; Length of Stay; Methadone; Neon | 2016 |
Psychometric assessment of the Neonatal Abstinence Scoring System and the MOTHER NAS Scale.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Absti | 2016 |
Newborn birth-weight of pregnant women on methadone or buprenorphine maintenance treatment: A national contingency management approach trial.
Topics: Adult; Age of Onset; Alcohol Drinking; Birth Weight; Buprenorphine; Cigarette Smoking; Female; Human | 2017 |
Correlations of maternal buprenorphine dose, buprenorphine, and metabolite concentrations in meconium with neonatal outcomes.
Topics: Adult; Buprenorphine; Cocaine; Double-Blind Method; Female; Humans; Infant, Newborn; Male; Maternal | 2008 |
Maternal methadone dosing schedule and fetal neurobehaviour.
Topics: Adult; Behavior; Cognition; Drug Administration Schedule; Female; Fetal Monitoring; Fetal Movement; | 2009 |
Smoking in pregnant women screened for an opioid agonist medication study compared to related pregnant and non-pregnant patient samples.
Topics: Adult; Cocaine-Related Disorders; Female; Health Behavior; Humans; Methadone; Narcotics; Opioid-Rela | 2009 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
(R)- and (S)-methadone and buprenorphine concentration ratios in maternal and umbilical cord plasma following chronic maintenance dosing in pregnancy.
Topics: Analgesics, Opioid; Buprenorphine; Drug Administration Schedule; Female; Fetal Blood; Humans; Infant | 2010 |
Maternal methadone dose, placental methadone concentrations, and neonatal outcomes.
Topics: Analgesics, Opioid; Apgar Score; Birth Weight; Body Size; Cephalometry; Cocaine; Female; Gestational | 2011 |
Treating the partners of opioid-dependent pregnant patients: feasibility and efficacy.
Topics: Adult; Counseling; Feasibility Studies; Female; Humans; Interpersonal Relations; Interview, Psycholo | 2011 |
Randomized controlled trials in pregnancy: scientific and ethical aspects. Exposure to different opioid medications during pregnancy in an intra-individual comparison.
Topics: Adult; Analgesics, Opioid; Birth Weight; Buprenorphine; Double-Blind Method; Female; Humans; Infant, | 2011 |
Buprenorphine versus methadone in pregnant opioid-dependent women: a prospective multicenter study.
Topics: Adult; Analgesics, Opioid; Birth Weight; Buprenorphine; Female; Heroin; Heroin Dependence; Humans; I | 2011 |
Methadone, cocaine, opiates, and metabolite disposition in umbilical cord and correlations to maternal methadone dose and neonatal outcomes.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Cocaine; Dose-Response Relationship, Drug; Female; Humans; | 2011 |
Impact of treatment approach on maternal and neonatal outcome in pregnant opioid-maintained women.
Topics: Adult; Austria; Birth Weight; Buprenorphine; Double-Blind Method; Female; Gestational Age; Humans; I | 2011 |
Are male neonates more vulnerable to neonatal abstinence syndrome than female neonates?
Topics: Birth Weight; Buprenorphine; Double-Blind Method; Female; Humans; Infant, Newborn; Male; Methadone; | 2011 |
Influence of site differences between urban and rural American and Central European opioid-dependent pregnant women and neonatal outcome characteristics.
Topics: Adolescent; Adult; Buprenorphine; Double-Blind Method; Europe; Female; Humans; Infant, Newborn; Meth | 2012 |
Peripartum pain management in opioid dependent women.
Topics: Adult; Analgesics; Buprenorphine; Cesarean Section; Delivery, Obstetric; Dose-Response Relationship, | 2012 |
Contingent incentives reduce cigarette smoking among pregnant, methadone-maintained women: results of an initial feasibility and efficacy randomized clinical trial.
Topics: Adult; Behavior Therapy; Carbon Monoxide; Feasibility Studies; Female; Humans; Methadone; Motivation | 2012 |
Illicit drug use among pregnant women enrolled in treatment for cigarette smoking cessation.
Topics: Adult; Analgesics, Opioid; Benzodiazepines; Cannabis; Cocaine; Demography; Female; Humans; Illicit D | 2013 |
Maternal Opioid Treatment: Human Experimental Research (MOTHER) Study: maternal, fetal and neonatal outcomes from secondary analyses.
Topics: Adolescent; Adult; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Sy | 2012 |
Fetal assessment before and after dosing with buprenorphine or methadone.
Topics: Adolescent; Adult; Analgesics, Opioid; Biophysical Phenomena; Buprenorphine; Double-Blind Method; Fe | 2012 |
Predicting treatment for neonatal abstinence syndrome in infants born to women maintained on opioid agonist medication.
Topics: Adolescent; Adult; Analgesics, Opioid; Birth Weight; Buprenorphine; Dose-Response Relationship, Drug | 2012 |
Differences in the profile of neonatal abstinence syndrome signs in methadone- versus buprenorphine-exposed neonates.
Topics: Adult; Analgesics, Opioid; Analysis of Variance; Buprenorphine; Double-Blind Method; Female; Humans; | 2012 |
Neonatal neurobehavior effects following buprenorphine versus methadone exposure.
Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Infant Behavior; Infant, Newbo | 2012 |
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.
Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind | 2012 |
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.
Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind | 2012 |
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.
Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind | 2012 |
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.
Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind | 2012 |
Infections and obstetric outcomes in opioid-dependent pregnant women maintained on methadone or buprenorphine.
Topics: Adolescent; Adult; Analgesics, Opioid; Analysis of Variance; Buprenorphine; Communicable Diseases; F | 2012 |
Effect of hepatitis C virus status on liver enzymes in opioid-dependent pregnant women maintained on opioid-agonist medication.
Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Female; gamma-Glutamyltransferase; Hepatitis C | 2012 |
Lessons learned from a comparison of evidence-based research in pregnant opioid-dependent women.
Topics: Adolescent; Adult; Buprenorphine; Double-Blind Method; Evidence-Based Medicine; Female; Humans; Infa | 2013 |
A comparison of cigarette smoking profiles in opioid-dependent pregnant patients receiving methadone or buprenorphine.
Topics: Adolescent; Adult; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-R | 2013 |
Motivational enhancement therapy for nicotine dependence in methadone-maintained pregnant women.
Topics: Adolescent; Adult; Analysis of Variance; Female; Humans; Linear Models; Methadone; Motivation; Opioi | 2004 |
Therapy of the neonatal abstinence syndrome with tincture of opium or morphine drops.
Topics: Double-Blind Method; Female; Humans; Infant, Newborn; Male; Methadone; Morphine; Neonatal Abstinence | 2005 |
Randomized controlled study transitioning opioid-dependent pregnant women from short-acting morphine to buprenorphine or methadone.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Humans; Methadone; Morphine; Opioid-Related Disor | 2005 |
Buprenorphine versus methadone in the treatment of pregnant opioid-dependent patients: effects on the neonatal abstinence syndrome.
Topics: Administration, Sublingual; Adult; Buprenorphine; Double-Blind Method; Female; Heroin Dependence; Hu | 2005 |
Methadone versus buprenorphine in pregnant addicts: a double-blind, double-dummy comparison study.
Topics: Buprenorphine; Double-Blind Method; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence | 2006 |
Management of neonatal abstinence syndrome in neonates born to opioid maintained women.
Topics: Adult; Apgar Score; Female; Gestational Age; Humans; Infant, Newborn; Male; Methadone; Morphine; Neo | 2007 |
Maternal vagal tone change in response to methadone is associated with neonatal abstinence syndrome severity in exposed neonates.
Topics: Adult; Apgar Score; Arrhythmia, Sinus; Electrocardiography; Female; Heart; Humans; Infant, Newborn; | 2007 |
Prospective randomised comparative study of the effect of buprenorphine, methadone and heroin on the course of pregnancy, birthweight of newborns, early postpartum adaptation and course of the neonatal abstinence syndrome (NAS) in women followed up in the
Topics: Adult; Birth Weight; Buprenorphine; Female; Fetal Growth Retardation; Heroin; Heroin Dependence; Hum | 2008 |
Neonatal methadone withdrawal. Effect of two treatment regimens.
Topics: Blood Pressure; Carbon Dioxide; Drug Administration Schedule; Female; Humans; Hydrogen-Ion Concentra | 1983 |
Postoperative analgesia for Caesarean section using epidural methadone.
Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Bupivacaine; Cesarean Section; Double-Blind Method; E | 1984 |
Methadone dosing and pregnancy: impact on program compliance.
Topics: Ambulatory Care; Cocaine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hu | 1995 |
Comparison of epidural methadone with epidural diamorphine for analgesia following caesarean section.
Topics: Analgesia, Epidural; Analgesia, Obstetrical; Cesarean Section; Double-Blind Method; Female; Heroin; | 1993 |
Evaluation of a cognitive-behavioural intervention for pregnant injecting drug users at risk of HIV infection.
Topics: Adult; Cognitive Behavioral Therapy; Combined Modality Therapy; Female; Follow-Up Studies; Health Kn | 1996 |
Attendance incentives for outpatient treatment: effects in methadone- and nonmethadone-maintained pregnant drug dependent women.
Topics: Adolescent; Adult; Ambulatory Care; Black or African American; Cocaine; Female; Humans; Infant, Newb | 1997 |
Comparison of methadone and slow-release morphine maintenance in pregnant addicts.
Topics: Adolescent; Adult; Delayed-Action Preparations; Female; Humans; Infant, Newborn; Methadone; Morphine | 1999 |
Slow-release morphine was not more effective than methadone in reducing neonatal abstinence syndrome.
Topics: Adult; Delayed-Action Preparations; Female; Humans; Infant, Newborn; Methadone; Morphine; Narcotics; | 2000 |
The effectiveness of incentives in enhancing treatment attendance and drug abstinence in methadone-maintained pregnant women.
Topics: Adult; Analysis of Variance; Chi-Square Distribution; Cocaine-Related Disorders; Female; Heroin Depe | 2001 |
A reinforcement-based therapeutic workplace for the treatment of drug abuse: six-month abstinence outcomes.
Topics: Adult; Cocaine-Related Disorders; Female; Heroin Dependence; Humans; Methadone; Narcotics; Pregnancy | 2001 |
[Withdrawal syndromes of newborns of pregnant drug abusers maintained under methadone or high-dose buprenorphine: 246 cases].
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Morphine; Neonatal Ab | 2001 |
Phase III clinical study of levo-alpha-acetylmethadol.
Topics: Clinical Trials as Topic; Drug Evaluation; Drug Interactions; Emotions; Female; Follow-Up Studies; H | 1976 |
Extradural methadone and bupivacaine in labour.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Bupivacaine; Double-Blind Method; Female; Humans | 1990 |
834 other studies available for methadone and Pregnancy
| Article | Year |
|---|---|
Opioid Use Disorder and Perinatal Outcomes.
Topics: Adult; Analgesics, Opioid; British Columbia; Buprenorphine; Female; Humans; Incidence; Infant, Newbo | 2021 |
A retrospective, observational study on medication for opioid use disorder during pregnancy and risk for neonatal abstinence syndrome.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant; Infant, Newborn; Methadone; Neonatal Abst | 2022 |
Use of Methadone Maintenance Therapy for Opioid Use Disorder in Pregnancy.
Topics: Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Pregnancy | 2021 |
Histological Changes Observed in Placentas Exposed to Medication-Assisted Treatment.
Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Opiate Substitution Treatment; Placenta; | 2021 |
Examining differences in retention on medication for opioid use disorder: An analysis of Ohio Medicaid data.
Topics: Adolescent; Analgesics, Opioid; Buprenorphine; Female; Humans; Medicaid; Methadone; Naltrexone; Ohio | 2022 |
Neonatal Abstinence Syndrome: Prevention, Recognition, Treatment, and Follow-up.
Topics: Analgesics, Opioid; Child, Preschool; Female; Follow-Up Studies; Humans; Infant, Newborn; Methadone; | 2021 |
Infant urinary metabolomic profile in a fatal acute methadone intoxication.
Topics: Asphyxia; Female; Humans; Infant; Infant, Newborn; Magnetic Resonance Spectroscopy; Metabolomics; Me | 2022 |
Harm Reduction for Patients With Substance Use Disorders.
Topics: Adult; Buprenorphine; Contraception; Drug Overdose; Female; Harm Reduction; Heroin; Humans; Male; Me | 2022 |
Risk factors for preterm birth among gravid individuals receiving buprenorphine for opioid use disorder.
Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Opioid-Related Disorders; Placenta; Pregn | 2022 |
Does self-reported consumption of heroin correlate with dose of methadone among pregnant people with opioid use disorder?
Topics: Analgesics, Opioid; Female; Heroin; Humans; Methadone; Opioid-Related Disorders; Pregnancy; Retrospe | 2022 |
Trends in the severity of opioid use disorder during pregnancy over time.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid- | 2022 |
Prenatal opioid exposure reprograms the behavioural response to future alcohol reward.
Topics: Analgesics, Opioid; Animals; Ethanol; Female; Male; Methadone; Mice; Pregnancy; Prenatal Exposure De | 2022 |
"You have to take this medication, but then you get punished for taking it:" lack of agency, choice, and fear of medications to treat opioid use disorder across the perinatal period.
Topics: Analgesics, Opioid; Buprenorphine; Child; Fear; Female; Humans; Infant, Newborn; Methadone; Opiate S | 2022 |
Neonatal Opioid Withdrawal Syndrome: A Comparison of As-Needed Pharmacotherapy.
Topics: Analgesics, Opioid; Female; Humans; Infant; Infant, Newborn; Methadone; Morphine; Neonatal Abstinenc | 2022 |
Association of Duration of Methadone or Buprenorphine Use During Pregnancy With Risk of Nonfatal Drug Overdose Among Pregnant Persons With Opioid Use Disorder in the US.
Topics: Buprenorphine; Drug Overdose; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Relat | 2022 |
Perinatal methadone exposure attenuates myelination and induces oligodendrocyte apoptosis in neonatal rat brain.
Topics: Animals; Animals, Newborn; Apoptosis; Brain; Female; Male; Methadone; Myelin Sheath; Oligodendroglia | 2022 |
Impact of prenatal substance use policies on commercially insured pregnant females with opioid use disorder.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opiate Overdose; Opiate Substitution T | 2022 |
Buprenorphine uptake during pregnancy following the 2017 guidelines update on prenatal opioid use disorder.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid- | 2022 |
Verbal and nonverbal memory in school-aged children born to opioid-dependent mothers.
Topics: Analgesics, Opioid; Buprenorphine; Child; Female; Humans; Longitudinal Studies; Methadone; Opiate Su | 2022 |
Characteristics of Prescription Opioid Analgesics in Pregnancy and Risk of Neonatal Opioid Withdrawal Syndrome in Newborns.
Topics: Adult; Analgesics, Opioid; Codeine; Cohort Studies; Female; Humans; Hydrocodone; Hydromorphone; Infa | 2022 |
Prenatal methadone exposure leads to long-term memory impairments and disruptions of dentate granule cell function in a sex-dependent manner.
Topics: Analgesics, Opioid; Animals; Dentate Gyrus; Female; Humans; Male; Memory, Long-Term; Methadone; Preg | 2022 |
Attitudes toward Medication for Opioid Use Disorder among Substance Use Treatment Providers.
Topics: Analgesics, Opioid; Buprenorphine; Child; Female; Humans; Methadone; Naltrexone; Opiate Substitution | 2022 |
Spatial and Nonspatial Factors Associated with Access to Medication for Opioid Use Disorder among Pregnant Women in Massachusetts.
Topics: Analgesics, Opioid; Buprenorphine; Female; Health Services Accessibility; Humans; Massachusetts; Met | 2022 |
Alterations of brain microstructures in a mouse model of prenatal opioid exposure detected by diffusion MRI.
Topics: Analgesics, Opioid; Animals; Brain; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging; | 2022 |
Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.
Topics: Buprenorphine; Cesarean Section; Cohort Studies; Female; Humans; Infant; Infant, Low Birth Weight; I | 2022 |
Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.
Topics: Buprenorphine; Cesarean Section; Cohort Studies; Female; Humans; Infant; Infant, Low Birth Weight; I | 2022 |
Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.
Topics: Buprenorphine; Cesarean Section; Cohort Studies; Female; Humans; Infant; Infant, Low Birth Weight; I | 2022 |
Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.
Topics: Buprenorphine; Cesarean Section; Cohort Studies; Female; Humans; Infant; Infant, Low Birth Weight; I | 2022 |
Association of medication-assisted treatment and short acting opioids with newborn head circumference and birth weight.
Topics: Analgesics, Opioid; Birth Weight; Buprenorphine; Cesarean Section; Female; Humans; Infant, Newborn; | 2023 |
Association of medication-assisted treatment and short acting opioids with newborn head circumference and birth weight.
Topics: Analgesics, Opioid; Birth Weight; Buprenorphine; Cesarean Section; Female; Humans; Infant, Newborn; | 2023 |
Association of medication-assisted treatment and short acting opioids with newborn head circumference and birth weight.
Topics: Analgesics, Opioid; Birth Weight; Buprenorphine; Cesarean Section; Female; Humans; Infant, Newborn; | 2023 |
Association of medication-assisted treatment and short acting opioids with newborn head circumference and birth weight.
Topics: Analgesics, Opioid; Birth Weight; Buprenorphine; Cesarean Section; Female; Humans; Infant, Newborn; | 2023 |
Buprenorphine-naloxone, buprenorphine, and methadone throughout pregnancy in maternal opioid use disorder.
Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Female; Humans; Illicit | 2023 |
How does a clinician approach the pharmacological management of opioid use disorders in pregnant women and pregnant people?
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid- | 2023 |
Comparative Safety Analysis of Opioid Agonist Treatment in Pregnant Women with Opioid Use Disorder: A Population-Based Study.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence S | 2023 |
Buprenorphine versus Methadone in Pregnancy.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opioid-Related Disorders; Pregnancy | 2023 |
Buprenorphine versus Methadone in Pregnancy. Reply.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opioid-Related Disorders; Pregnancy | 2023 |
Initiation and Treatment Discontinuation of Medications for Opioid Use Disorder in Pregnant People Compared With Nonpregnant People.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; | 2023 |
Treatment access for opioid use disorder among women with medicaid in Florida.
Topics: Analgesics, Opioid; Buprenorphine; Female; Florida; Humans; Medicaid; Methadone; Opiate Substitution | 2023 |
United States county jail treatment and care of pregnant incarcerated persons with opioid use disorder.
Topics: Analgesics, Opioid; Buprenorphine; Cross-Sectional Studies; Female; Humans; Jails; Methadone; Opiate | 2023 |
Feasibility of methadone for pain relief in first trimester abortion.
Topics: Abortion, Induced; Feasibility Studies; Female; Humans; Methadone; Pain; Pain Management; Pregnancy; | 2023 |
Feasibility of methadone for pain relief in first trimester abortion (Boston, Massachusetts 2022).
Topics: Abortion, Induced; Boston; Feasibility Studies; Female; Humans; Massachusetts; Methadone; Pain; Preg | 2023 |
Methadone alters transcriptional programs associated with synapse formation in human cortical organoids.
Topics: Analgesics, Opioid; Brain; Female; Humans; Infant; Methadone; Opiate Substitution Treatment; Opioid- | 2023 |
Effect of Neonatal Abstinence Syndrome Treatment Status and Maternal Depressive Symptomatology on Maternal Reports of Infant Behaviors.
Topics: Analgesics, Opioid; Female; Humans; Infant; Infant, Newborn; Methadone; Mothers; Neonatal Abstinence | 2023 |
A comparison of postpartum opioid consumption and opioid discharge prescriptions among opioid-naïve patients and those with opioid use disorder.
Topics: Analgesics, Opioid; Buprenorphine; Drug Prescriptions; Female; Humans; Methadone; Morphine Derivativ | 2023 |
Trends in smoking during pregnancy stratified by the use of opioid agonist therapy and the contribution of smoking to poor outcome in neonates prenatally exposed to opioid agonist treatment.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Opiate Substitution T | 2023 |
Perturbed neurochemical and microstructural organization in a mouse model of prenatal opioid exposure: A multi-modal magnetic resonance study.
Topics: Analgesics, Opioid; Animals; Brain; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging; | 2023 |
Methadone administered to rat dams during pregnancy and lactation affects the circadian rhythms of their pups.
Topics: Animals; Circadian Rhythm; Female; Lactation; Melatonin; Methadone; Pineal Gland; Pregnancy; Rats; S | 2023 |
Long-Term Visual and Neurodevelopmental Outcomes in Two Children with Congenital Nystagmus Secondary to Methadone Exposure In utero.
Topics: Child; Female; Humans; Infant; Methadone; Nystagmus, Congenital; Pregnancy; Prenatal Exposure Delaye | 2023 |
Distribution of morphine and methadone to the brain in a developmental chicken embryo model.
Topics: Analgesics, Opioid; Animals; Brain; Chick Embryo; Chickens; Chromatography, Liquid; Drug Tolerance; | 2023 |
Health and Neurodevelopment of Children Born to Opioid-Dependent Mothers at School Entry.
Topics: Child of Impaired Parents; Child, Preschool; Female; Health Status; Humans; Infant; Infant, Newborn; | 2020 |
Prenatal exposure to opioid maintenance treatment and neonatal outcomes: Nationwide registry studies from the Czech Republic and Norway.
Topics: Adult; Buprenorphine; Child Development; Czech Republic; Female; Humans; Infant, Newborn; Logistic M | 2019 |
Management of Newborns with Prenatal Opioid Exposure: One Institution's Journey.
Topics: Analgesics, Opioid; Female; Humans; Infant, Newborn; Length of Stay; Methadone; Morphine; Neonatal A | 2019 |
Drug screening during pregnancy: Urine dip cups measure up.
Topics: Amphetamines; Analgesics, Opioid; Benzodiazepines; Buprenorphine; Cocaine; Female; Humans; Laborator | 2019 |
Salivary cortisol levels relate to cognitive performance in children prenatally exposed to methadone or buprenorphine.
Topics: Analgesics, Opioid; Buprenorphine; Child; Child Development; Cohort Studies; Female; Humans; Hydroco | 2020 |
Methadone, Buprenorphine, or Detoxification for Management of Perinatal Opioid Use Disorder: A Cost-Effectiveness Analysis.
Topics: Buprenorphine; Cost-Benefit Analysis; Decision Support Techniques; Female; Humans; Methadone; Narcot | 2019 |
Educational achievement at age 9.5 years of children born to mothers maintained on methadone during pregnancy.
Topics: Achievement; Child; Educational Status; Female; Humans; Logistic Models; Male; Mathematics; Methadon | 2019 |
Buprenorphine compared with methadone in opioid-dependent pregnant women: How does it affect neonatal abstinence syndrome?
Topics: Adult; Buprenorphine; Female; Humans; Infant; Infant, Newborn; Length of Stay; Methadone; Narcotic A | 2019 |
Long-time effects of prenatal morphine, tramadol, methadone, and buprenorphine exposure on seizure and anxiety in immature rats.
Topics: Animals; Animals, Newborn; Anxiety; Behavior, Animal; Buprenorphine; Female; Locomotion; Male; Maze | 2020 |
Diverse changes in myelin protein expression in rat brain after perinatal methadone exposure.
Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; Animals; Brain; Female; Male; Methadone; Myelin Basic | 2019 |
Substance use disorder treatment services for pregnant and postpartum women in residential and outpatient settings.
Topics: Buprenorphine; Female; Health Services Accessibility; Humans; Methadone; Opioid-Related Disorders; O | 2020 |
Initial Management of Incarcerated Pregnant Women With Opioid Use Disorder.
Topics: Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; P | 2020 |
Stereoselective Analysis of Methadone and EDDP in Laboring Women and Neonates in Plasma and Dried Blood Spots and Association with Neonatal Abstinence Syndrome.
Topics: Analgesics, Opioid; Anticonvulsants; Dried Blood Spot Testing; Female; Humans; Infant, Newborn; Labo | 2021 |
Opioid use disorder incidence and treatment among incarcerated pregnant women in the United States: results from a national surveillance study.
Topics: Analgesics, Opioid; Buprenorphine; Cross-Sectional Studies; Female; Humans; Incidence; Methadone; Na | 2020 |
Screening for Opioid and Stimulant Exposure In Utero Through Targeted and Untargeted Metabolomics Analysis of Umbilical Cords.
Topics: Analgesics, Opioid; Central Nervous System Stimulants; Chromatography, Liquid; Cocaine; Female; Huma | 2020 |
Emerging therapies for the treatment of neonatal abstinence syndrome.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Morphine; Neonatal Ab | 2022 |
Methadone, Buprenorphine, or Detoxification for Management of Perinatal Opioid Use Disorder: A Cost-Effectiveness Analysis.
Topics: Buprenorphine; Cost-Benefit Analysis; Female; Humans; Infant, Newborn; Methadone; Opiate Substitutio | 2020 |
Necrotizing enterocolitis and its association with the neonatal abstinence syndrome.
Topics: Analgesics, Opioid; Buprenorphine; Cohort Studies; Enterocolitis, Necrotizing; Female; Fetal Blood; | 2020 |
Pregnant Smokers Receiving Opioid Agonist Therapy Have an Elevated Nicotine Metabolite Ratio: A Replication Study.
Topics: Analgesics, Opioid; Bupropion; Cotinine; Female; Humans; Methadone; Nicotine; Opiate Substitution Tr | 2020 |
Living a normal life? Follow-up study of women who had been in opioid maintenance treatment during pregnancy.
Topics: Buprenorphine; Child; Female; Follow-Up Studies; Humans; Methadone; Opiate Substitution Treatment; O | 2020 |
Prenatal exposure to methadone or buprenorphine impairs cognitive performance in young adult rats.
Topics: Animals; Animals, Newborn; Buprenorphine; Cognition; Female; Infusion Pumps, Implantable; Male; Memo | 2020 |
Opioid Use Disorder Treatment Facilities With Programs for Special Populations.
Topics: Adolescent; Adult; Depression, Postpartum; Female; Humans; Infant, Newborn; Male; Methadone; Middle | 2020 |
Assessment of Racial and Ethnic Disparities in the Use of Medication to Treat Opioid Use Disorder Among Pregnant Women in Massachusetts.
Topics: Adult; Black or African American; Buprenorphine; Female; Healthcare Disparities; Hispanic or Latino; | 2020 |
Pain outcomes among patients after cesarean consuming buprenorphine or methadone and opioid-naïve patients.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opioid-Related Disorders; Pain; Pregna | 2020 |
Effects of polysubstance exposure on neonatal outcomes for infants with intrauterine opioid exposure.
Topics: Analgesics, Opioid; Female; Humans; Infant; Infant, Newborn; Length of Stay; Methadone; Morphine; Ne | 2020 |
Comparison of buprenorphine and methadone in the management of maternal opioid use disorder in full term pregnancies.
Topics: Birth Weight; Buprenorphine; Delivery, Obstetric; Female; Humans; Infant, Newborn; Length of Stay; M | 2020 |
Medications for opioid use disorder in pregnancy in a state women's prison facility.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; North Carolina; Opioid-Related | 2020 |
Adverse neonatal outcomes associated with maternal severe mental health diagnoses and opioid use.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Mental Health; Methadone; Neonat | 2020 |
Drug abuse during pregnancy and its neonatal impact. Analysis of the periods 2002-2008 and 2009-2017.
Topics: Cocaine; Female; Humans; Infant, Newborn; Methadone; Methamphetamine; Pregnancy; Pregnancy Complicat | 2021 |
Integration of a contraception clinic into an opioid treatment setting to improve contraception knowledge, accessibility and uptake: a pilot study.
Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Contraception; Delivery of Health Care, Integr | 2020 |
Orchestrated Testing of Formula Type to Reduce Length of Stay in Neonatal Abstinence Syndrome.
Topics: Energy Intake; Female; Humans; Infant Formula; Infant, Newborn; Lactose; Length of Stay; Methadone; | 2020 |
A mixed methods study exploring methadone treatment disclosure and perceptions of reproductive health care among women ages 18-44 years, Los Angeles, CA.
Topics: Adolescent; Adult; Disclosure; Female; Humans; Los Angeles; Methadone; Perception; Pregnancy; Qualit | 2020 |
Contraception Practices Among Women on Opioid Agonist Therapy.
Topics: Adult; British Columbia; Buprenorphine, Naloxone Drug Combination; Contraception; Contraception Beha | 2021 |
Oxybutynin for methadone-induced sweating in pregnancy.
Topics: Female; Humans; Mandelic Acids; Methadone; Pregnancy; Surveys and Questionnaires; Sweating | 2021 |
Neurobehavior of newborn infants exposed prenatally to methadone and identification of a neurobehavioral profile linked to poorer neurodevelopmental outcomes at age 24 months.
Topics: Adult; Analgesics, Opioid; Attention; Case-Control Studies; Child Development; Female; Humans; Infan | 2020 |
Methadone interrupts neural growth and function in human cortical organoids.
Topics: Action Potentials; Female; Humans; Infant, Newborn; Methadone; Organoids; Patch-Clamp Techniques; Pr | 2020 |
Prevalence and Geographic Distribution of Obstetrician-Gynecologists Who Treat Medicaid Enrollees and Are Trained to Prescribe Buprenorphine.
Topics: Adult; Buprenorphine; Cross-Sectional Studies; Female; Humans; Infant, Newborn; Male; Medicaid; Meth | 2020 |
Is Maternal Methadone Dose Associated with the Severity of Neonatal Abstinence Syndrome?
Topics: Female; Humans; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome; Opioid-Related D | 2022 |
Delivery dose of methadone, but not buprenorphine, is associated with the risk and severity of neonatal opiate withdrawal syndrome.
Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Pregnancy; Pregnancy Complications; Prosp | 2020 |
Neonatal abstinence syndrome in neonates born of mothers in drug-assisted rehabilitation.
Topics: Female; Humans; Infant; Infant, Newborn; Methadone; Mothers; Neonatal Abstinence Syndrome; Norway; O | 2021 |
Are point-of-care urine drug testing devices suitable for antenatal drug screening? A study verifying the Alere® Drug Screen Test Cup for the detection of six classes of drug in a pregnant population.
Topics: Amphetamine; Benzodiazepines; Buprenorphine; Chromatography, Liquid; Cocaine; Female; Gas Chromatogr | 2021 |
Cost effectiveness of buprenorphine vs. methadone for pregnant people with opioid use disorder.
Topics: Analgesics, Opioid; Buprenorphine; Cerebral Palsy; Cost-Benefit Analysis; Female; Fetal Growth Retar | 2022 |
Prenatal methadone exposure and child developmental outcomes in 2-year-old children.
Topics: Adult; Child Development; Child, Preschool; Confounding Factors, Epidemiologic; Female; Humans; Infa | 2021 |
Desire to avoid pregnancy and contraceptive use among female methadone patients in Los Angeles.
Topics: Contraception; Contraception Behavior; Contraceptive Agents; Female; Humans; Los Angeles; Methadone; | 2021 |
Prenatal methadone exposure impairs adolescent cognition and GABAergic neurodevelopment in a novel rat model of maternal methadone treatment.
Topics: Analgesics, Opioid; Animals; Brain; Brain-Derived Neurotrophic Factor; Cognition; Disease Models, An | 2021 |
Mental health and use of health care services in opioid-exposed school-aged children compared to foster children.
Topics: Analgesics, Opioid; Child; Child, Foster; Delivery of Health Care; Female; Foster Home Care; Humans; | 2022 |
Prenatal methadone exposure disrupts behavioral development and alters motor neuron intrinsic properties and local circuitry.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Brain; Female; Humans; Male; Maternal Exposure; Metha | 2021 |
Conceptualizing stigma in contexts of pregnancy and opioid misuse: A qualitative study with women and healthcare providers in Ohio.
Topics: Adult; Buprenorphine; Female; Health Personnel; Humans; Infant, Newborn; Methadone; Neonatal Abstine | 2021 |
Leveraging Telehealth in the United States to Increase Access to Opioid Use Disorder Treatment in Pregnancy and Postpartum During the COVID-19 Pandemic.
Topics: Adult; Buprenorphine; Comorbidity; Comprehensive Health Care; COVID-19; Delivery of Health Care; Evi | 2021 |
Impact of opioid maintenance treatment during pregnancy on neonatal birth weight and head circumference.
Topics: Analgesics, Opioid; Birth Weight; Buprenorphine; Female; Humans; Infant; Infant, Newborn; Male; Meth | 2021 |
Methadone and buprenorphine discontinuation among postpartum women with opioid use disorder.
Topics: Adult; Analgesics, Opioid; Black or African American; Buprenorphine; Correctional Facilities; Ethnic | 2021 |
Outcomes associated with the use of medications for opioid use disorder during pregnancy.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant; Infant, Newborn; Methadone; Neonatal Abst | 2021 |
Affective decision-making in children prenatally exposed to opioids.
Topics: Analgesics, Opioid; Buprenorphine; Child; Child Development; Cognition; Decision Making; Female; Hum | 2021 |
Nail disease in neonatal abstinence syndrome.
Topics: Female; Humans; Infant; Infant, Newborn; Male; Methadone; Nail Diseases; Neonatal Abstinence Syndrom | 2021 |
Racial inequity in methadone dose at delivery in pregnant women with opioid use disorder.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid- | 2021 |
Can buprenorphine be used for opioid use disorder during pregnancy?
Topics: Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; P | 2021 |
Prenatal opioid administration induces shared alterations to the maternal and offspring gut microbiome: A preliminary analysis.
Topics: Analgesics, Opioid; Animals; Female; Gastrointestinal Microbiome; Male; Methadone; Mice; Pregnancy; | 2021 |
Variations in Infant CYP2B6 Genotype Associated with the Need for Pharmacological Treatment for Neonatal Abstinence Syndrome in Infants of Methadone-Maintained Opioid-Dependent Mothers.
Topics: Adult; Analgesics, Opioid; Cohort Studies; Cytochrome P-450 CYP2B6; Female; Genetic Variation; Human | 2017 |
Infants Born to Opioid-Dependent Women in Ontario, 2002-2014.
Topics: Adult; Buprenorphine; Congenital Abnormalities; Databases, Factual; Female; Health Care Costs; Human | 2017 |
A Retrospective Cohort Study of Birth Outcomes in Neonates Exposed to Naltrexone in Utero: A Comparison with Methadone-, Buprenorphine- and Non-opioid-Exposed Neonates.
Topics: Adult; Australia; Buprenorphine; Drug Administration Routes; Female; Humans; Incidence; Infant, Newb | 2017 |
An Initiative to Improve the Quality of Care of Infants With Neonatal Abstinence Syndrome.
Topics: Female; Hospital Costs; Humans; Infant, Newborn; Length of Stay; Male; Methadone; Morphine; Narcotic | 2017 |
Characteristics and Outcome of Male and Female Methadone Maintenance Patients: MMT in Tel Aviv and Las Vegas.
Topics: Adult; Age Factors; Analgesics, Opioid; Benzodiazepines; Cocaine; Female; Humans; Israel; Male; Meth | 2018 |
Hepatitis C Cascade of Care Among Pregnant Women on Opioid Agonist Pharmacotherapy Attending a Comprehensive Prenatal Program.
Topics: Adult; Analgesics, Opioid; Female; Hepacivirus; Hepatitis C; Humans; Mass Screening; Methadone; Mexi | 2017 |
Sensorimotor outcomes in children with prenatal exposure to methadone.
Topics: Age of Onset; Exotropia; Female; Humans; Infant; Methadone; Narcotics; Neonatal Abstinence Syndrome; | 2017 |
Association of methadone dose with substance use and treatment retention in pregnant and postpartum women with opioid use disorder.
Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Humans; Methadone; Opiate Subst | 2017 |
Transitioning from methadone to buprenorphine maintenance in management of opioid use disorder during pregnancy.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Drug Substitution; Female; Humans; Infant, Newborn; Methad | 2018 |
Increased DNA Methylation of ABCB1, CYP2D6, and OPRM1 Genes in Newborn Infants of Methadone-Maintained Opioid-Dependent Mothers.
Topics: Adult; Analgesics, Opioid; ATP Binding Cassette Transporter, Subfamily B; Case-Control Studies; Coho | 2017 |
Maternal buprenorphine treatment and infant outcome.
Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Opiate Subs | 2017 |
Antenatal methadone vs buprenorphine exposure and length of hospital stay in infants admitted to the intensive care unit with neonatal abstinence syndrome.
Topics: Adult; Buprenorphine; Female; Gestational Age; Humans; Infant, Newborn; Intensive Care Units, Neonat | 2018 |
Methadone Versus Buprenorphine for Opioid Use Dependence and Risk of Neonatal Abstinence Syndrome.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Absti | 2018 |
Medicaid Coverage of Methadone Maintenance and the Use of Opioid Agonist Therapy Among Pregnant Women in Specialty Treatment.
Topics: Adult; Cross-Sectional Studies; Eligibility Determination; Female; Health Services Accessibility; Hu | 2017 |
A retrospective cohort study of the health of children prenatally exposed to methadone, buprenorphine or naltrexone compared with non-exposed control children.
Topics: Adult; Buprenorphine; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Longitudinal | 2017 |
Invited Commentary: A Novel Strategy for Addressing Unmeasured Confounding When Comparing Opioid Agonist Therapies in Pregnancy.
Topics: Buprenorphine; Female; Humans; Infant, Newborn; Medicaid; Methadone; Opiate Substitution Treatment; | 2018 |
Neonatal Outcomes in a Medicaid Population With Opioid Dependence.
Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Narcotics; Opioid-Related Disorders; Preg | 2018 |
Early inhibitory control and working memory abilities of children prenatally exposed to methadone.
Topics: Adult; Behavioral Symptoms; Case-Control Studies; Child, Preschool; Executive Function; Female; Huma | 2018 |
Use of Marijuana and Other Substances Among Pregnant and Parenting Women With Substance Use Disorders: Changes in Washington State After Marijuana Legalization.
Topics: Adult; Amphetamines; Female; Humans; Legislation, Drug; Marijuana Abuse; Marijuana Smoking; Methadon | 2018 |
Prenatal methadone exposure is associated with altered neonatal brain development.
Topics: Brain; Child; Child Development; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging; Fem | 2018 |
The Role of Preterm Birth in the Association Between Opioid Maintenance Therapy and Neonatal Abstinence Syndrome.
Topics: Adult; Buprenorphine; Female; Humans; Infant, Newborn; Maternal Age; Methadone; Neonatal Abstinence | 2018 |
Neonatal outcomes after fetal exposure to methadone and buprenorphine: national registry studies from the Czech Republic and Norway.
Topics: Abortion, Spontaneous; Adult; Analgesics, Opioid; Apgar Score; Buprenorphine; Czech Republic; Female | 2018 |
Treating women with opioid use disorder during pregnancy in Appalachia: Initial neonatal outcomes following buprenorphine + naloxone exposure.
Topics: Adult; Appalachian Region; Birth Weight; Buprenorphine, Naloxone Drug Combination; Female; Humans; I | 2018 |
Pregnancy and the Opioid Epidemic.
Topics: Analgesics, Opioid; Epidemics; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndr | 2018 |
Opioid Utilization by Pregnant Women with Sickle Cell Disease and the Risk of Neonatal Abstinence Syndrome.
Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Case-Control Studies; Female; Humans; Incidence; Met | 2018 |
Barriers and Facilitators of Breastfeeding Reported by Postpartum Women in Methadone Maintenance Therapy.
Topics: Adolescent; Adult; Breast Feeding; Cross-Sectional Studies; Female; Humans; Infant; Infant Nutrition | 2018 |
Quality improvement initiative to improve inpatient outcomes for Neonatal Abstinence Syndrome.
Topics: Adult; Female; Hospital Costs; Humans; Infant, Newborn; Inpatients; Length of Stay; Male; Methadone; | 2018 |
Early Treatment Innovation for Opioid-Dependent Newborns: A Retrospective Comparison of Outcomes, Utilization, Quality, and Safety, 2006-2014.
Topics: Child Protective Services; Community Health Services; Continuity of Patient Care; Cooperative Behavi | 2018 |
Barriers to accessing treatment for pregnant women with opioid use disorder in Appalachian states.
Topics: Analgesics, Opioid; Appalachian Region; Buprenorphine; Female; Health Expenditures; Health Personnel | 2019 |
ERP correlates of cognitive control in children prenatally exposed to methadone or buprenorphine.
Topics: Buprenorphine; Child; Cognition; Evoked Potentials; Female; Humans; Longitudinal Studies; Male; Meth | 2018 |
Fatal and Nonfatal Overdose Among Pregnant and Postpartum Women in Massachusetts.
Topics: Adult; Buprenorphine; Drug Overdose; Female; Humans; Massachusetts; Methadone; Opiate Substitution T | 2018 |
Trends and Outcomes Associated With Using Long-Acting Opioids During Delivery Hospitalizations.
Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Delivery, Obstetric; Female; Guideline Adheren | 2018 |
Prenatal Treatment and Outcomes of Women With Opioid Use Disorder.
Topics: Adult; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disor | 2018 |
Impact of psychiatric medication co-exposure on Neonatal Abstinence Syndrome severity.
Topics: Adult; Analgesics, Opioid; Benzodiazepines; Buprenorphine; Female; Gabapentin; Humans; Infant; Infan | 2018 |
Buprenorphine medication-assisted treatment during pregnancy: An exploratory factor analysis associated with adherence.
Topics: Adult; Buprenorphine; Factor Analysis, Statistical; Female; Humans; Infant, Newborn; Medication Adhe | 2018 |
Impact of timing of methadone initiation on perinatal outcomes following delivery among pregnant women on methadone maintenance therapy in Ontario.
Topics: Adolescent; Adult; Analgesics, Opioid; Drug Administration Schedule; Female; Humans; Methadone; Midd | 2019 |
Relationship Between Methadone, Selective Serotonin Reuptake Inhibitors, and Neonatal Abstinence Syndrome.
Topics: Adult; Cohort Studies; Female; Humans; Infant, Newborn; Intensive Care Units, Neonatal; Length of St | 2016 |
Novel Withdrawal Symptoms of a Neonate Prenatally Exposed to a Fentanyl Analog.
Topics: Anticonvulsants; Clonidine; Female; Fentanyl; Humans; Infant, Newborn; Levetiracetam; Methadone; Myo | 2019 |
Could prenatal food insecurity influence neonatal abstinence syndrome severity?
Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Food Supply; Humans; Methadone; Neonatal Abstinenc | 2019 |
Children exposed to maternal methadone treatment prenatally are at risk of abnormal neurodevelopment.
Topics: Child; Female; Humans; Methadone; Pregnancy; Prenatal Exposure Delayed Effects | 2019 |
Integrated Brief Intervention for PTSD and Substance Use in an Antepartum Unit.
Topics: Adaptation, Psychological; Adult; Alcoholism; Benzodiazepines; Buprenorphine; Female; Humans; Matern | 2019 |
Coordinating Outpatient Care for Pregnant and Postpartum Women with Opioid Use Disorder: Implications from the COACHH Program.
Topics: Adult; Ambulatory Care; Analgesics, Opioid; Female; Humans; Interviews as Topic; Massachusetts; Meth | 2019 |
Best Practices for Pregnant Incarcerated Women With Opioid Use Disorder.
Topics: Buprenorphine; Female; Humans; Methadone; Narcotics; Opiate Substitution Treatment; Opioid-Related D | 2019 |
Medical specialty of buprenorphine prescribers for pregnant women with opioid use disorder.
Topics: Analgesics, Opioid; Buprenorphine; Drug Prescriptions; Female; Humans; Medicaid; Methadone; Opiate S | 2019 |
Hospitalization of children after prenatal exposure to opioid maintenance therapy during pregnancy: a national registry study from the Czech Republic.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Case-Control Studies; Child, Preschool; Czech Republic; Di | 2019 |
Inadequate prenatal care utilization among women with and without methadone-treated opioid use disorders in Taiwan.
Topics: Adult; Case-Control Studies; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Relate | 2019 |
Prescription Drug and Alcohol Use Disorders: Opioid Use Disorder.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Naltrexone; Opiate Substitution Treatm | 2019 |
Implications of perinatal buprenorphine exposure on infant head circumference at birth.
Topics: Buprenorphine; Female; Humans; Infant; Infant, Newborn; Male; Methadone; Neonatal Abstinence Syndrom | 2021 |
Medication-Assisted Treatment Use Among Pregnant Women With Opioid Use Disorder.
Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Cohort Studies; Databases, Factual; Female; Hu | 2019 |
Factors associated with treatment retention in pregnant women with opioid use disorders prescribed methadone or electing non-pharmacological treatment.
Topics: Adult; Baltimore; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders | 2020 |
Placental trophoblast transfer of opioids following exposures to individual or mixtures of opioids
Topics: Analgesics, Opioid; Female; Fentanyl; Gas Chromatography-Mass Spectrometry; Heroin; Humans; Maternal | 2019 |
Methadone, Pierre Robin sequence and other congenital anomalies: case-control study.
Topics: Adult; Case-Control Studies; Cleft Palate; Comorbidity; Europe; Female; Gestational Age; Humans; Inf | 2020 |
Interventions for the Treatment of Neonatal Abstinence Syndrome.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Male; Methadone; Morphine; Neona | 2019 |
Opioid receptor-mediated changes in the NMDA receptor in developing rat and chicken.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Cerebellum; Chickens; Female; Methadone; Morphine; Pregn | 2019 |
Treating perinatal opioid use disorder in rural settings: Challenges and opportunities.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; New Hampshire; Opiate Substitut | 2019 |
High Accumulation of Methadone Compared with Buprenorphine in Fetal Rat Brain after Maternal Exposure.
Topics: Analgesics, Opioid; Animals; Body Weight; Brain; Buprenorphine; Female; Fetus; Male; Maternal-Fetal | 2019 |
Prevalence of Maternal-Risk Factors Related to Neonatal Abstinence Syndrome in a Commercial Claims Database: 2011-2015.
Topics: Adult; Analgesics, Opioid; Drug Prescriptions; Female; Humans; Incidence; Infant, Newborn; Insurance | 2019 |
Evaluation of a Nurse-Led Program for Rural Pregnant Women With Opioid Use Disorder to Improve Maternal-Neonatal Outcomes.
Topics: Adult; Buprenorphine; Databases, Factual; Female; Hospitals, Community; Humans; Infant Health; Massa | 2019 |
Use of naltrexone in treating opioid use disorder in pregnancy.
Topics: Abortion, Spontaneous; Adult; Analgesics, Opioid; Buprenorphine; Case-Control Studies; Female; Human | 2020 |
Neonatal visual evoked potentials in infants born to mothers prescribed methadone.
Topics: Cohort Studies; Evoked Potentials, Visual; Female; Humans; Infant, Newborn; Male; Methadone; Pilot P | 2013 |
Predictors of neonatal outcomes amongst a methadone- and/or heroin-dependent population referred to a multidisciplinary Perinatal and Family Drug Health Service.
Topics: Adult; Child Custody; Female; Gestational Age; Heroin Dependence; Humans; Infant, Low Birth Weight; | 2013 |
Development of sensitization to methamphetamine in offspring prenatally exposed to morphine, methadone and buprenorphine.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Buprenorphine; Central Nervous System Stimulants; Fem | 2014 |
Treating opioid use disorders during pregnancy: historical, current, and future directions.
Topics: Buprenorphine; Disease Management; Female; History, 19th Century; History, 20th Century; History, 21 | 2013 |
Trends in the average prescribed dose of methadone: more than a proxy for the evolution of severity of opioid dependence.
Topics: Female; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy; Pregnancy Complications | 2013 |
Re: Letter from J. Trujols, N. Siñol & J. Pérez De Los Cobos.
Topics: Female; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy; Pregnancy Complications | 2013 |
Substance, structure and stigma: parents in the UK accounting for opioid substitution therapy during the antenatal and postnatal periods.
Topics: Adult; Analgesics, Opioid; Drug Users; Family Relations; Female; Humans; Interviews as Topic; Longit | 2013 |
The obstetrical and neonatal impact of maternal opioid detoxification in pregnancy.
Topics: Adult; Cohort Studies; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Opi | 2013 |
Deviant smooth pursuit in preschool children exposed prenatally to methadone or buprenorphine and tobacco affects integrative visuomotor capabilities.
Topics: Analysis of Variance; Buprenorphine; Child, Preschool; Cohort Studies; Female; Humans; Male; Methado | 2013 |
Congenital nystagmus in two infants born from mothers exposed to methadone during pregnancy.
Topics: Female; Humans; Infant; Infant, Newborn; Maternal Exposure; Methadone; Narcotics; Nystagmus, Congeni | 2013 |
Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Computer Simulation; Cytochrome P-450 CYP | 2014 |
In utero drug and alcohol exposure in infants born to mothers prescribed maintenance methadone.
Topics: Analgesics, Opioid; Central Nervous System Depressants; Ethanol; Female; Humans; Illicit Drugs; Infa | 2013 |
Alternative matrices for cocaine, heroin, and methadone in utero drug exposure detection.
Topics: Chromatography, Liquid; Cocaine; Drug Monitoring; Female; Hair; Heroin; Humans; Maternal-Fetal Excha | 2013 |
Response to Chandler et al., Substance, structure and stigma: parents in the UK accounting for opioid substitution therapy during the antenatal and postnatal periods.
Topics: Analgesics, Opioid; Drug Users; Female; Humans; Male; Methadone; Opiate Substitution Treatment; Opio | 2013 |
Maternal stress and behavioral adaptation in methadone- or buprenorphine-exposed toddlers.
Topics: Adult; Anxiety; Buprenorphine; Child; Child, Preschool; Depression; Family; Female; Humans; Longitud | 2013 |
Development of auditory event-related potentials in infants prenatally exposed to methadone.
Topics: Acoustic Stimulation; Adult; Auditory Cortex; Electroencephalography; Evoked Potentials, Auditory; F | 2014 |
Social determinants of methadone in pregnancy: violence, social capital, and mental health.
Topics: Domestic Violence; Female; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy; Risk F | 2013 |
Clinical care for opioid-using pregnant and postpartum women: the role of obstetric providers.
Topics: Analgesics, Opioid; Buprenorphine; Confidentiality; Dose-Response Relationship, Drug; Emergency Serv | 2014 |
Integrated care for pregnant women on methadone maintenance treatment: Canadian primary care cohort study.
Topics: Adolescent; Adult; Analgesics, Opioid; Canada; Cohort Studies; Delivery of Health Care, Integrated; | 2013 |
Effectiveness of a clinical pathway with methadone treatment protocol for treatment of neonatal abstinence syndrome following in utero drug exposure to substances of abuse*.
Topics: Analgesics, Opioid; Clinical Protocols; Female; Humans; Infant, Newborn; Intensive Care Units, Neona | 2014 |
Effect of prenatal methadone on reinstated behavioral sensitization induced by methamphetamine in adolescent rats.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Female; Methadone; Methamphetamine; Mo | 2014 |
Reply: To PMID 23727040.
Topics: Female; Humans; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Complications | 2014 |
The obstetric and neonatal impact of maternal opioid detoxification in pregnancy.
Topics: Female; Humans; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Complications | 2014 |
Visual outcome in infants born to drug-misusing mothers prescribed methadone in pregnancy.
Topics: Evoked Potentials, Visual; Eye Diseases; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; | 2014 |
Rates of fetal polydrug exposures in methadone-maintained pregnancies from a high-risk population.
Topics: Adult; Cocaine; Female; Humans; Infant, Newborn; Meconium; Methadone; Opiate Substitution Treatment; | 2013 |
Reduced fetal growth in methadone-maintained pregnancies is not fully explained by smoking or socio-economic deprivation.
Topics: Adult; Analgesics, Opioid; Birth Weight; Cohort Studies; Female; Fetal Growth Retardation; Head; Hum | 2014 |
Searching the right way to treat neonatal abstinence syndrome*.
Topics: Analgesics, Opioid; Female; Humans; Male; Methadone; Neonatal Abstinence Syndrome; Pregnancy; Pregna | 2014 |
Commentary on Mactier et al. (2014): Methadone-assisted treatment and the complexity of influences on fetal development.
Topics: Analgesics, Opioid; Birth Weight; Female; Fetal Growth Retardation; Humans; Male; Methadone; Opioid- | 2014 |
Use of hair testing to determine methadone exposure in pediatric deaths.
Topics: Breast Feeding; Child of Impaired Parents; Female; Forensic Toxicology; Hair; Humans; Infant; Male; | 2014 |
Breastfeeding and Methadone Therapy: The Maternal Experience.
Topics: Adolescent; Adult; Analgesics, Opioid; Breast Feeding; Contraindications; Female; Focus Groups; Heal | 2015 |
Postpartum changes in methadone maintenance dose.
Topics: Adult; Benzodiazepines; Cohort Studies; Female; Humans; Methadone; Narcotics; Opiate Substitution Tr | 2014 |
Neonatal abstinence syndrome: on the evidence to add breastfeeding to any clinical pathway.
Topics: Analgesics, Opioid; Female; Humans; Male; Methadone; Neonatal Abstinence Syndrome; Pregnancy; Pregna | 2014 |
The authors reply.
Topics: Analgesics, Opioid; Female; Humans; Male; Methadone; Neonatal Abstinence Syndrome; Pregnancy; Pregna | 2014 |
Characteristics and quality of life of opioid-dependent pregnant women in Austria.
Topics: Administration, Oral; Adult; Austria; Buprenorphine; Delayed-Action Preparations; Female; Humans; Me | 2014 |
The opioid system and brain development: effects of methadone on the oligodendrocyte lineage and the early stages of myelination.
Topics: Animals; Axons; Brain; Cell Lineage; Cell Proliferation; Female; Methadone; Myelin Basic Protein; My | 2014 |
Comparison of adverse obstetric outcomes and maternity hospitalization among heroin-exposed and methadone-treated women in Taiwan.
Topics: Adult; Cohort Studies; Female; Heroin Dependence; Hospitalization; Humans; Length of Stay; Methadone | 2015 |
Identification of early developmental deficits in infants with prenatal heroin, methadone, and other opioid exposure.
Topics: Analgesics, Opioid; Child Development; Developmental Disabilities; Female; Heroin; Humans; Infant; I | 2015 |
Executive function in preschool children prenatally exposed to methadone or buprenorphine.
Topics: Analgesics, Opioid; Buprenorphine; Case-Control Studies; Child; Child Development; Child, Preschool; | 2015 |
Visual selective attention is impaired in children prenatally exposed to opioid agonist medication.
Topics: Analgesics, Opioid; Attention; Buprenorphine; Case-Control Studies; Child, Preschool; Female; Humans | 2015 |
Contribution of in utero drug exposure when interpreting hair results in young children.
Topics: Amitriptyline; Bromazepam; Cannabinoids; Diazepam; Diphenhydramine; Female; Forensic Toxicology; Hai | 2015 |
Infants of opioid-dependent mothers: neurodevelopment at six months.
Topics: Adult; Analgesics, Opioid; Case-Control Studies; Child Development; Female; Humans; Infant; Infant, | 2015 |
Management of neonatal abstinence syndrome in the newborn nursery.
Topics: Female; Humans; Infant, Newborn; Methadone; Mother-Child Relations; Neonatal Abstinence Syndrome; Pr | 2014 |
Buprenorphine and naloxone compared with methadone treatment in pregnancy.
Topics: Adult; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naloxone; Narcotic Antagonists; Na | 2015 |
Buprenorphine and naloxone compared with methadone treatment in pregnancy.
Topics: Adult; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naloxone; Narcotic Antagonists; Na | 2015 |
Buprenorphine and naloxone compared with methadone treatment in pregnancy.
Topics: Adult; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naloxone; Narcotic Antagonists; Na | 2015 |
Buprenorphine and naloxone compared with methadone treatment in pregnancy.
Topics: Adult; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naloxone; Narcotic Antagonists; Na | 2015 |
Maternal Substance Use and Neonatal Abstinence Syndrome: A Descriptive Study.
Topics: Adolescent; Adult; Female; Humans; Infant, Newborn; Length of Stay; Methadone; Mothers; Neonatal Abs | 2015 |
First Dutch national guidelines--pharmacological care for detained opioid addicts.
Topics: Buprenorphine; Communicable Diseases; Comorbidity; Continuity of Patient Care; Female; Health Policy | 2009 |
Caring for Opioid-dependent Pregnant Women: Prenatal and Postpartum Care Considerations.
Topics: Alcohol-Related Disorders; Breast Feeding; Counseling; Female; Humans; Incidence; Infant, Newborn; M | 2015 |
UHPLC-MS/MS quantification of buprenorphine, norbuprenorphine, methadone, and glucuronide conjugates in umbilical cord plasma.
Topics: Blood Chemical Analysis; Blood Specimen Collection; Buprenorphine; Chromatography, High Pressure Liq | 2015 |
Growth and developmental outcome of infants with in-utero exposure to methadone vs buprenorphine.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Infant; Infant, Newborn; Infant, Premature | 2015 |
Beneficial effects of co-treatment with dextromethorphan on prenatally methadone-exposed offspring.
Topics: Animals; Antitussive Agents; Dextromethorphan; Female; Male; Methadone; Morphine Dependence; Narcoti | 2015 |
Maternal methadone treatment and neonatal abstinence syndrome.
Topics: Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Length of Stay; Logistic Models | 2015 |
Tapering from Methadone or Buprenorphine during Pregnancy: Maternal and Neonatal Outcomes in Norway 1996-2009.
Topics: Adult; Birth Weight; Buprenorphine; Drug Administration Schedule; Female; Humans; Infant, Newborn; M | 2015 |
Exposure to prescription opioid analgesics in utero and risk of neonatal abstinence syndrome: population based cohort study.
Topics: Adolescent; Adult; Analgesics, Opioid; Cohort Studies; Dose-Response Relationship, Drug; Female; Hum | 2015 |
Obstetrical and neonatal outcomes of methadone-maintained pregnant women: a canadian multisite cohort study.
Topics: Adult; Birth Weight; Breast Feeding; Canada; Female; Gestational Age; Humans; Infant, Newborn; Lengt | 2015 |
Maternal use of methadone and risk of sudden neonatal death.
Topics: Adult; Female; Humans; Infant, Newborn; Male; Methadone; Narcotics; Opioid-Related Disorders; Perina | 2015 |
Methadone versus buprenorphine for the treatment of opioid abuse in pregnancy: science and stigma.
Topics: Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; P | 2015 |
Opioid use disorder during pregnancy in Tennessee: expediency vs. science.
Topics: Buprenorphine; Female; Humans; Insurance Coverage; Medicaid; Methadone; Opiate Substitution Treatmen | 2015 |
Caring for pregnant opioid abusers in Vermont: A potential model for non-urban areas.
Topics: Adult; Buprenorphine; Community Health Centers; Female; Health Services Accessibility; Humans; Infan | 2015 |
Neonatal abstinence syndrome: Historical perspective, current focus, future directions.
Topics: Adult; Analgesics, Opioid; Female; History, 19th Century; History, 20th Century; History, 21st Centu | 2015 |
Cohort Analysis of a Pharmacokinetic-Modeled Methadone Weaning Optimization for Neonatal Abstinence Syndrome.
Topics: Adult; Analgesics, Opioid; Cohort Studies; Female; Humans; Infant, Newborn; Length of Stay; Male; Me | 2015 |
Revision of Breastfeeding Guidelines in the Setting of Maternal Opioid Use Disorder: One Institution's Experience.
Topics: Analgesics, Opioid; Boston; Breast Feeding; Buprenorphine; Female; Health Promotion; Humans; Infant, | 2016 |
Retrospective chart review comparing morphine and methadone in neonates treated for neonatal abstinence syndrome.
Topics: Administration, Oral; Analgesics, Opioid; Female; Humans; Infant, Newborn; Male; Methadone; Morphine | 2015 |
Rooming-in for Infants at Risk of Neonatal Abstinence Syndrome.
Topics: Adult; Analgesics, Opioid; Bottle Feeding; Breast Feeding; Canada; Female; Humans; Infant, Newborn; | 2016 |
US pledges better protection for babies born to addicts.
Topics: Adult; Child of Impaired Parents; Child Protective Services; Female; Heroin Dependence; Humans; Infa | 2016 |
ADHD risk alleles associated with opiate addiction: study of addicted parents and their children.
Topics: Adolescent; Alleles; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Female; | 2016 |
Simultaneous quantification of buprenorphine, naloxone and phase I and II metabolites in plasma and breastmilk by liquid chromatography-tandem mass spectrometry.
Topics: Buprenorphine; Chromatography, Liquid; Female; Glucuronides; Humans; Infant, Newborn; Metabolic Deto | 2016 |
Evaluation of the vaginal flora in pregnant women receiving opioid maintenance therapy: a matched case-control study.
Topics: Adult; Analgesics, Opioid; Asymptomatic Infections; Austria; Birth Weight; Buprenorphine; Candidiasi | 2016 |
Opioid detoxification during pregnancy: the door continues to open.
Topics: Analgesics, Opioid; Female; Humans; Methadone; Narcotic Antagonists; Opioid-Related Disorders; Pregn | 2016 |
Bioanalysis for cocaine, opiates, methadone, and amphetamines exposure detection during pregnancy.
Topics: Amphetamines; Analgesics, Opioid; Anesthetics, Local; Central Nervous System Stimulants; Cocaine; Fe | 2017 |
Mother-child interaction and cognitive development in children prenatally exposed to methadone or buprenorphine.
Topics: Adult; Buprenorphine; Case-Control Studies; Child Development; Cognition; Female; Humans; Infant, Ne | 2016 |
Characteristics of Maternal-Infant Interaction During Treatment for Opioid Withdrawal.
Topics: Adolescent; Adult; Bottle Feeding; Case-Control Studies; Female; Humans; Infant, Newborn; Male; Meth | 2016 |
Neonatal Abstinence Syndrome: Twelve Years of Experience at a Regional Referral Center.
Topics: Buprenorphine; Diseases in Twins; Female; Hospitalization; Humans; Infant, Newborn; Male; Methadone; | 2017 |
Neonatal abstinence syndrome and the gastrointestinal tract.
Topics: Analgesics, Opioid; Buprenorphine; Child; Child, Preschool; Dysbiosis; Female; Gastrointestinal Trac | 2016 |
The relationship between gestational age and the severity of neonatal abstinence syndrome.
Topics: Adult; Analgesics, Opioid; Female; Gestational Age; Humans; Infant, Newborn; Intensive Care Units, N | 2017 |
An Atypical Withdrawal Syndrome in Neonates Prenatally Exposed to Gabapentin and Opioids.
Topics: Amines; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid | 2017 |
Early Treatment for Neonatal Abstinence Syndrome: A Palliative Approach.
Topics: Analgesics, Opioid; Female; Humans; Infant, Newborn; Length of Stay; Male; Methadone; Neonatal Absti | 2017 |
Buprenorphine, Norbuprenorphine, R-Methadone, and S-Methadone Upregulate BCRP/ABCG2 Expression by Activating Aryl Hydrocarbon Receptor in Human Placental Trophoblasts.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Buprenorphine; Female; Gene Knockdown Techn | 2017 |
Delayed villous maturation in term placentas exposed to opioid maintenance therapy: a retrospective cohort study.
Topics: Adult; Buprenorphine; Case-Control Studies; Chorionic Villi; Cohort Studies; Female; Humans; Methado | 2017 |
Response to Smith and Brogly et al. commentaries on Zedler et al.
Topics: Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; P | 2016 |
The comparative safety of buprenorphine versus methadone in pregnancy-what about confounding?
Topics: Buprenorphine; Female; Humans; Methadone; Neonatal Abstinence Syndrome; Opiate Substitution Treatmen | 2016 |
A case of infant delirium in the neonatal intensive care unit.
Topics: Amines; Analgesics, Opioid; Anti-Anxiety Agents; Cardiac Catheterization; Cyclohexanecarboxylic Acid | 2017 |
Neonatal abstinence syndrome.
Topics: Female; Humans; Infant; Infant, Newborn; Male; Maternal-Fetal Exchange; Methadone; Morphine; Mothers | 2008 |
Comparison of characteristics of opioid-using pregnant women in rural and urban settings.
Topics: Adult; Buprenorphine; Demography; Female; Humans; Mass Screening; Methadone; Narcotic Antagonists; O | 2008 |
Nails of newborns in monitoring drug exposure during pregnancy.
Topics: Caffeine; Central Nervous System Stimulants; Cocaine; Cotinine; Dopamine Uptake Inhibitors; Female; | 2008 |
Chronic hepatitis C in pregnancy.
Topics: Adult; Cholestasis; Comorbidity; Female; Hepatitis C, Chronic; Humans; Infant, Newborn; Methadone; N | 2008 |
Drugs and pregnancy--outcomes of women engaged with a specialist perinatal outreach addictions service.
Topics: Behavior, Addictive; Cross-Sectional Studies; Female; Health Promotion; Humans; London; Methadone; P | 2008 |
Outcome in infants exposed to methadone in utero.
Topics: Developmental Disabilities; Female; Humans; Infant; Infant, Newborn; Methadone; Narcotics; Pregnancy | 2008 |
Acoustic cry characteristics of infants exposed to methadone during pregnancy.
Topics: Abnormalities, Drug-Induced; Acoustics; Analgesics, Opioid; Crying; Female; Humans; Infant Welfare; | 2009 |
Newer obstetric analgesics; preliminary evaluation of compounds No. 10720 and No. 10820 (dolophine).
Topics: Analgesia; Analgesics; Anesthesia; Anesthesiology; Female; Humans; Methadone; Obstetrics; Pregnancy | 1948 |
Maternal and neonatal effects of substance abuse during pregnancy: our ten-year experience.
Topics: Adult; Apgar Score; Birth Weight; Croatia; Female; Heroin; Heroin Dependence; Humans; Incidence; Inf | 2008 |
High-dose methadone in pregnant women and its effect on duration of neonatal abstinence syndrome.
Topics: Adult; Anticonvulsants; Cohort Studies; Dose-Response Relationship, Drug; Female; Humans; Infant, Ne | 2009 |
Distribution of saquinavir, methadone, and buprenorphine in maternal brain, placenta, and fetus during two different gestational stages of pregnancy in mice.
Topics: Animals; Brain; Buprenorphine; Female; Fetal Development; Fetus; Maternal Exposure; Maternal-Fetal E | 2009 |
[Substitution treatment of drug addicts during pregnancy: consequences for the children?].
Topics: Buprenorphine; Developmental Disabilities; Female; Humans; Infant, Newborn; Methadone; Narcotics; Ne | 2009 |
Maternal methadone use in pregnancy: factors associated with the development of neonatal abstinence syndrome and implications for healthcare resources.
Topics: Adolescent; Adult; Breast Feeding; Dose-Response Relationship, Drug; Drug Users; Female; Gestational | 2009 |
Opioid maintenance treatment during pregnancy: occurrence and severity of neonatal abstinence syndrome. A national prospective study.
Topics: Adult; Buprenorphine; Cohort Studies; Female; Humans; Infant, Newborn; Male; Methadone; Neonatal Abs | 2009 |
Comparison of drugs of abuse detection in meconium by EMIT II and ELISA.
Topics: Amphetamines; Analgesics, Opioid; Barbiturates; Benzodiazepines; Cannabinoids; Chromatography, Liqui | 2009 |
Buprenorphine and pregnancy.
Topics: Buprenorphine; Congenital Abnormalities; Female; France; Humans; Infant, Newborn; Methadone; Neonata | 2009 |
Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy.
Topics: Acute Disease; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Buprenorphine; Controlled Clinic | 2009 |
Women treated with methadone are at high risk for poor obstetrical and neonatal outcome.
Topics: Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Sy | 2009 |
The influence of maternal opiate use in pregnancy on second trimester biochemical markers for Down syndrome.
Topics: Adult; Biomarkers; Case-Control Studies; Down Syndrome; Female; Heroin; Humans; Methadone; Opioid-Re | 2009 |
The impact of cocaine and heroin on the placental transfer of methadone.
Topics: Antipyrine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbon Radioisotopes; Cocaine; | 2009 |
Pregnancy and neonatal characteristics of opioid-dependent Indigenous Australians: a rural and metropolitan comparison.
Topics: Adult; Analgesics, Opioid; Australia; Female; Humans; Infant, Newborn; Methadone; Native Hawaiian or | 2009 |
Methadone and buprenorphine prescribing and referral practices in US prison systems: results from a nationwide survey.
Topics: Buprenorphine; Drug Utilization; Female; Health Care Surveys; Heroin Dependence; Humans; Male; Metha | 2009 |
Risk factors for preterm birth among opiate-addicted gravid women in a methadone treatment program.
Topics: Adult; Analgesics, Opioid; Comorbidity; Female; Humans; Methadone; Odds Ratio; Opioid-Related Disord | 2009 |
Efficacy of oral sucrose in infants of methadone-maintained mothers.
Topics: Administration, Oral; Adult; Analgesia; Analgesics; Blood Specimen Collection; Female; Gestational A | 2010 |
Development and validation of a liquid chromatography mass spectrometry assay for the simultaneous quantification of methadone, cocaine, opiates and metabolites in human umbilical cord.
Topics: Chromatography, Liquid; Cocaine; Drug Stability; Female; Humans; Least-Squares Analysis; Mass Spectr | 2009 |
Simultaneous quantification of methadone, cocaine, opiates, and metabolites in human placenta by liquid chromatography-mass spectrometry.
Topics: Adult; Analgesics, Opioid; Chromatography, High Pressure Liquid; Cocaine; Female; Humans; Methadone; | 2009 |
Prenatal methadone exposure and neonatal neurobehavioral functioning.
Topics: Analysis of Variance; Female; Humans; Infant, Newborn; Lethargy; Maternal Exposure; Methadone; Movem | 2009 |
S-Methadone augments R-methadone induced respiratory depression in the neonatal guinea pig.
Topics: Age Factors; Analgesics, Opioid; Analysis of Variance; Animals; Animals, Newborn; Disease Models, An | 2009 |
Treatment of neonatal abstinence syndrome with clonidine and chloral hydrate.
Topics: Blood Pressure; Chloral Hydrate; Clonidine; Drug Therapy, Combination; Female; Humans; Hypnotics and | 2010 |
Comparative effects of drugs on P-glycoprotein expression and activity using rat and human trophoblast models.
Topics: Animals; Aspirin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Dose-Res | 2010 |
Drug addiction during pregnancy: correlations between the placental health and the newborn's outcome - elaboration of a predictive score.
Topics: Adult; Analgesics, Opioid; Cannabis; Cocaine; Ethanol; Female; Gestational Age; Humans; Infant, Newb | 2009 |
Screening for hepatitis C virus infection in methadone-maintained mothers and their infants.
Topics: Adult; Analgesics, Opioid; Female; Hepatitis C; Humans; Infant; Infant, Newborn; Methadone; Neonatal | 2009 |
Patterns in sleep-wakefulness in three-month old infants exposed to methadone or buprenorphine.
Topics: Adult; Buprenorphine; Chronobiology Disorders; Female; Humans; Infant; Infant Behavior; Infant, Newb | 2009 |
Characteristics of opioid-using pregnant women who accept or refuse participation in a clinical trial: screening results from the MOTHER study.
Topics: Adolescent; Adult; Demography; Female; Humans; Methadone; Opioid-Related Disorders; Patient Selectio | 2009 |
Gas chromatography-mass spectrometry assay for the simultaneous quantification of drugs of abuse in human placenta at 12th week of gestation.
Topics: Abortion, Induced; Amphetamines; Cocaine; Cotinine; Dronabinol; Female; Forensic Toxicology; Ganglio | 2010 |
The impact of mood disorders on the delivery and neonatal outcomes of methadone-maintained pregnant patients.
Topics: Adult; Analysis of Variance; Chi-Square Distribution; Diagnosis, Dual (Psychiatry); Female; Genital | 2009 |
The impact of mood disorders on the delivery and neonatal outcomes of methadone-maintained pregnant patients.
Topics: Adult; Analysis of Variance; Chi-Square Distribution; Diagnosis, Dual (Psychiatry); Female; Genital | 2009 |
The impact of mood disorders on the delivery and neonatal outcomes of methadone-maintained pregnant patients.
Topics: Adult; Analysis of Variance; Chi-Square Distribution; Diagnosis, Dual (Psychiatry); Female; Genital | 2009 |
The impact of mood disorders on the delivery and neonatal outcomes of methadone-maintained pregnant patients.
Topics: Adult; Analysis of Variance; Chi-Square Distribution; Diagnosis, Dual (Psychiatry); Female; Genital | 2009 |
Infant autonomic functioning and neonatal abstinence syndrome.
Topics: Adult; Apgar Score; Autonomic Nervous System; Cocaine-Related Disorders; Data Interpretation, Statis | 2010 |
Miadone (physeptone) in obstetrics.
Topics: Female; Humans; Methadone; Obstetrics; Pregnancy | 1947 |
Amidone (miadone) as an obstetric analgesic: trial in 62 cases.
Topics: Analgesics; Female; Humans; Methadone; Pregnancy | 1947 |
Newer obstetric analgesics; compounds No. 10720 and No. 10820, dolophine.
Topics: Analgesics; Anesthesia; Anesthesia, Obstetrical; Anesthesiology; Female; Gynecology; Methadone; Obst | 1947 |
Growth restriction in pregnancies of opioid-dependent mothers.
Topics: Adult; Body Mass Index; Dose-Response Relationship, Drug; Epidemiologic Methods; Female; Fetal Growt | 2010 |
Ophthalmic, clinical and visual electrophysiological findings in children born to mothers prescribed substitute methadone in pregnancy.
Topics: Child; Child, Preschool; Evoked Potentials, Visual; Eye Diseases; Female; Humans; Infant; Maternal-F | 2010 |
Multidisciplinary antenatal care for opiate-using women: Child-care issues.
Topics: Appointments and Schedules; Female; Foster Home Care; Heroin; Heroin Dependence; Humans; Infant, New | 2010 |
Relationship between maternal methadone dose at delivery and neonatal abstinence syndrome.
Topics: Cohort Studies; Female; Humans; Incidence; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinenc | 2010 |
Infant neurobehavior following prenatal exposure to methadone or buprenorphine: results from the neonatal intensive care unit network neurobehavioral scale.
Topics: Adult; Akathisia, Drug-Induced; Buprenorphine; Female; Humans; Infant, Newborn; Intensive Care Units | 2010 |
Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome.
Topics: Breast Feeding; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Infant, Premature | 2011 |
Enhancement of tolerance development to morphine in rats prenatally exposed to morphine, methadone, and buprenorphine.
Topics: Analgesics; Animals; Buprenorphine; Disease Models, Animal; Drug Tolerance; Female; Heroin Dependenc | 2010 |
Gender and NAS: does sex matter?
Topics: Analgesics, Opioid; Female; Humans; Infant, Newborn; Male; Methadone; Morphine; Neonatal Abstinence | 2010 |
Excretion of methadone in sweat of pregnant women throughout gestation after controlled methadone administration.
Topics: Adult; Analgesics, Opioid; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Drug Monitoring; | 2010 |
Perinatal risk factors for the neonatal abstinence syndrome in infants born to women on methadone maintenance therapy.
Topics: Adult; Female; Humans; Infant, Newborn; Logistic Models; Methadone; Narcotics; Neonatal Abstinence S | 2010 |
High-throughput simultaneous analysis of buprenorphine, methadone, cocaine, opiates, nicotine, and metabolites in oral fluid by liquid chromatography tandem mass spectrometry.
Topics: Anesthetics, Local; Buprenorphine; Chromatography, Liquid; Cocaine; Female; Ganglionic Stimulants; H | 2010 |
Postnatal weight loss in substitute methadone-exposed infants: implications for the management of breast feeding.
Topics: Adolescent; Adult; Birth Weight; Bottle Feeding; Breast Feeding; Female; Gestational Age; Humans; In | 2012 |
Methadone disposition in oral fluid during pharmacotherapy for opioid-dependence.
Topics: Chromatography, Liquid; Female; Humans; Hydrogen-Ion Concentration; Mass Spectrometry; Methadone; Me | 2011 |
A special type of 'hard-to-reach' patient: experiences of pregnant women on methadone.
Topics: Female; Humans; Interviews as Topic; Maternal Health Services; Methadone; New Zealand; Opioid-Relate | 2010 |
Prenatal methadone exposure, meconium biomarker concentrations and neonatal abstinence syndrome.
Topics: Adult; Analgesics, Opioid; Cocaine; Cocaine-Related Disorders; Female; Gestational Age; Humans; Infa | 2010 |
Neonatal and maternal outcomes following maternal use of buprenorphine or methadone during pregnancy: findings of a retrospective audit.
Topics: Adult; Buprenorphine; Female; Humans; Infant, Newborn; Maternal Health Services; Maternal Welfare; M | 2011 |
Infant mortality among women on a methadone program during pregnancy.
Topics: Adult; Female; Humans; Infant Mortality; Infant, Newborn; Live Birth; Medical Record Linkage; Methad | 2010 |
Maternal methadone therapy increases QTc interval in newborn infants.
Topics: Case-Control Studies; Electrocardiography; Female; Humans; Infant, Newborn; Long QT Syndrome; Male; | 2011 |
Association between intrapartum fetal heart rate patterns and neonatal abstinence syndrome in methadone exposed neonates.
Topics: Adult; Analgesics, Opioid; Female; Heart Rate, Fetal; Humans; Infant, Newborn; Labor, Obstetric; Mat | 2011 |
Methadone and perinatal outcomes: a retrospective cohort study.
Topics: Age Factors; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Methadone; Narcotics | 2011 |
Higher maternal doses of methadone does not increase neonatal abstinence syndrome.
Topics: Adult; Birth Weight; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Methadone; N | 2011 |
[Assisted reproductive technique for an opiates dependant couple].
Topics: Adult; Female; Fertilization in Vitro; Hepatitis C, Chronic; Humans; Male; Methadone; Opiate Substit | 2011 |
Estimated infant exposure to enantiomer-specific methadone levels in breastmilk.
Topics: Adolescent; Adult; Analgesics, Opioid; Breast Feeding; Dose-Response Relationship, Drug; Female; Hum | 2011 |
Changes in methadone maintenance therapy during and after pregnancy.
Topics: Adult; Analgesics, Opioid; Computers; Dose-Response Relationship, Drug; Drug Administration Schedule | 2011 |
Methadone and perinatal outcomes: another perspective.
Topics: Female; Humans; Methadone; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Opioid-Relat | 2011 |
Duration of methadone maintenance treatment during pregnancy and pregnancy outcome parameters in women with opiate addiction.
Topics: Adult; Birth Weight; Dose-Response Relationship, Drug; Female; Gestational Age; Humans; Infant, Newb | 2012 |
Neonatal abstinence syndrome: transitioning methadone-treated infants from an inpatient to an outpatient setting.
Topics: Ambulatory Care; Female; Hospitalization; Humans; Infant, Newborn; Infant, Premature, Diseases; Leng | 2012 |
The relationship between maternal opioid agonists and psychiatric medications on length of hospitalization for neonatal abstinence syndrome.
Topics: Boston; Buprenorphine; Cross-Sectional Studies; Drug Interactions; Drug Therapy, Combination; Female | 2011 |
The worldwide opioid epidemic: implications for treatment and research in pregnancy and the newborn.
Topics: Analgesics, Opioid; Biomedical Research; Buprenorphine; Female; Humans; Infant, Newborn; Internation | 2011 |
Efficacy versus effectiveness of buprenorphine and methadone maintenance in pregnancy.
Topics: Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; P | 2011 |
Pregnancies exposed to methadone, methadone and other illicit substances, and poly-drugs without methadone: a comparison of fetal neurobehaviors and infant outcomes.
Topics: Adult; Female; Fetal Monitoring; Humans; Illicit Drugs; Infant, Newborn; Methadone; Neonatal Abstine | 2012 |
Pregnancies exposed to methadone, methadone and other illicit substances, and poly-drugs without methadone: a comparison of fetal neurobehaviors and infant outcomes.
Topics: Adult; Female; Fetal Monitoring; Humans; Illicit Drugs; Infant, Newborn; Methadone; Neonatal Abstine | 2012 |
Pregnancies exposed to methadone, methadone and other illicit substances, and poly-drugs without methadone: a comparison of fetal neurobehaviors and infant outcomes.
Topics: Adult; Female; Fetal Monitoring; Humans; Illicit Drugs; Infant, Newborn; Methadone; Neonatal Abstine | 2012 |
Pregnancies exposed to methadone, methadone and other illicit substances, and poly-drugs without methadone: a comparison of fetal neurobehaviors and infant outcomes.
Topics: Adult; Female; Fetal Monitoring; Humans; Illicit Drugs; Infant, Newborn; Methadone; Neonatal Abstine | 2012 |
The impact of infant feeding method on neonatal abstinence scores of methadone-exposed infants.
Topics: Adolescent; Adult; Analysis of Variance; Breast Feeding; Female; Humans; Infant Formula; Infant, New | 2011 |
A pilot study of the nutritional status of opiate-using pregnant women on methadone maintenance therapy.
Topics: Adult; Body Composition; Body Mass Index; Energy Intake; Fatty Acids, Essential; Female; Humans; Mal | 2012 |
Medication-assisted treatment in criminal justice agencies affiliated with the criminal justice-drug abuse treatment studies (CJ-DATS): availability, barriers, and intentions.
Topics: Adult; Buprenorphine; Crime; Criminal Law; Data Collection; Female; Humans; Male; Methadone; Naltrex | 2012 |
Strength in numbers: a step closer to standardising perinatal care for drug-misusing women and their infants.
Topics: Female; Humans; Methadone; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Pregna | 2012 |
Unplanned pregnancy and contraceptive use in women attending drug treatment services.
Topics: Adult; Buprenorphine; Contraception Behavior; Delivery of Health Care, Integrated; Drug Users; Femal | 2012 |
Methadone and perinatal outcomes: a prospective cohort study.
Topics: Adult; Benzodiazepines; Dose-Response Relationship, Drug; Female; Heroin Dependence; Humans; Infant, | 2012 |
Opioid dependency in pregnancy and length of stay for neonatal abstinence syndrome.
Topics: Adult; Buprenorphine; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule | 2012 |
Methadone and metabolites in hair of methadone-assisted pregnant women and their infants.
Topics: Adolescent; Adult; Female; Hair; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; O | 2012 |
Perinatal effects of combined use of heroin, methadone, and amphetamine during pregnancy and quantitative measurement of metabolites in hair.
Topics: Adult; Amphetamine; Electroencephalography; Female; Fetus; Gas Chromatography-Mass Spectrometry; Hai | 2012 |
Development of a substance abuse program for opioid-dependent nonurban pregnant women improves outcome.
Topics: Buprenorphine; Cohort Studies; Combined Modality Therapy; Female; Health Services Accessibility; Hum | 2012 |
ACOG Committee Opinion No. 524: Opioid abuse, dependence, and addiction in pregnancy.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence S | 2012 |
Are infants exposed to methadone in utero at an increased risk for mortality?
Topics: Adult; Analgesics, Opioid; Cause of Death; Female; Humans; Infant; Infant Mortality; Infant, Newborn | 2012 |
Maternal and neonatal outcomes following methadone substitution during pregnancy.
Topics: Adult; Analgesics, Opioid; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Premature; Me | 2012 |
Subsequent anxiety-related behavior in rats exposed to low-dose methadone during gestation, lactation or both periods consecutively.
Topics: Animals; Anxiety; Behavior, Animal; Dose-Response Relationship, Drug; Female; Growth; Lactation; Met | 2012 |
Treatment of opioid dependence in the setting of pregnancy.
Topics: Adolescent; Alcohol-Related Disorders; Analgesics, Opioid; Buprenorphine; Child; Comorbidity; Delive | 2012 |
Neural tract development of infants born to methadone-maintained mothers.
Topics: Analgesics, Opioid; Brain; Brain Mapping; Developmental Disabilities; Diffusion Tensor Imaging; Fema | 2012 |
Neurodevelopmental investigation of the mirror neurone system in children of women receiving opioid maintenance therapy during pregnancy.
Topics: Adult; Analysis of Variance; Buprenorphine; Case-Control Studies; Child, Preschool; Developmental Di | 2013 |
Quantitative prediction of CYP2B6 induction by estradiol during pregnancy: potential explanation for increased methadone clearance during pregnancy.
Topics: Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Biotransformation; Bupropion; Carbamazepine; Cell | 2013 |
Neonatal outcomes following in utero exposure to methadone or buprenorphine: a National Cohort Study of opioid-agonist treatment of Pregnant Women in Norway from 1996 to 2009.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Cohort Studies; Female; Follow-Up Studies; Humans; Infant, | 2013 |
Pharmacologic evidence to support clinical decision making for peripartum methadone treatment.
Topics: Adolescent; Adult; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; | 2013 |
Methadone use in pregnancy: evidence of progression in the severity of addiction.
Topics: Adult; England; Female; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy; Pregnancy | 2012 |
Patterns of symptom reporting during pregnancy comparing opioid maintained and control women.
Topics: Adult; Buprenorphine; Case-Control Studies; Female; Humans; Methadone; Opiate Substitution Treatment | 2012 |
Methadone dosing and prescribed medication use in a prospective cohort of opioid-dependent pregnant women.
Topics: Anti-Bacterial Agents; Antidepressive Agents; Benzodiazepines; Female; Humans; Hypnotics and Sedativ | 2013 |
Efficacy and safety of intraoperative intravenous methadone during general anaesthesia for caesarean delivery: a retrospective case-control study.
Topics: Adult; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Genera | 2013 |
Comments on: Efficacy versus effectiveness of buprenorphine and methadone maintenance in pregnancy.
Topics: Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; P | 2012 |
Dual dilemma-should naltrexone be used in the treatment of opioid-dependent pregnant women?
Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naltrexone; Narcotic Antagonists; Narcoti | 2013 |
Blocking endogenous opioids during development--do we understand the consequences?
Topics: Animals; Brain; Buprenorphine; Female; Fetal Development; Humans; Methadone; Naltrexone; Narcotic An | 2013 |
Management of the pregnant substance abusing woman.
Topics: Analgesics, Opioid; Female; Humans; Maternal Health Services; Methadone; Opioid-Related Disorders; P | 2013 |
Simultaneous determination of opiates, methadone, amphetamines, cocaine, and metabolites in human placenta and umbilical cord by LC-MS/MS.
Topics: Amphetamine; Analgesics, Opioid; Chromatography, Liquid; Cocaine; Female; Humans; Limit of Detection | 2013 |
Methadone trough levels in pregnancy.
Topics: Female; Heroin; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy; Pregnancy Complic | 2002 |
Relationship between maternal methadone dosage and neonatal withdrawal.
Topics: Adult; Analysis of Variance; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration S | 2002 |
Strabismus in infants of opiate-dependent mothers.
Topics: Australia; Codeine; Cross-Sectional Studies; Female; Heroin; Humans; Infant; Infant, Newborn; Male; | 2003 |
Prenatal methadone exposure: effects on behavior in early infancy.
Topics: Adult; Analysis of Variance; Child Development; Female; Follow-Up Studies; Humans; Infant; Infant Be | 1982 |
Maternal drug use and length of neonatal unit stay.
Topics: Adult; Female; Humans; Infant, Newborn; Intensive Care, Neonatal; Length of Stay; London; Methadone; | 2003 |
Is opiate detoxification unsafe in pregnancy?
Topics: Abortion, Spontaneous; Adult; Female; Heroin; Humans; Methadone; Obstetric Labor, Premature; Opioid- | 2003 |
Neonatal hair analysis contribution to establishing a gestational drug exposure profile and predicting a withdrawal syndrome.
Topics: Cannabinoids; Cocaine; Female; Gas Chromatography-Mass Spectrometry; Hair; Humans; Infant, Newborn; | 2003 |
[Coagulation effect of methadon during labor; comparative biological, biochemical and biophysical studies].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Female; Humans; Labor, Obstetric; Methadone; Pain M | 1956 |
Dipipanone hydrochloride as an adjunct to anaesthesia in obstetrics and surgery.
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Female; Humans; Labor, Obstetric; Methadone; Obstet | 1957 |
Dipipanone hydrochloride (pipadone) as a pre-delivery sedative and analgesic.
Topics: Analgesia; Analgesics; Anesthesia; Anesthesia and Analgesia; Female; Humans; Hypnotics and Sedatives | 1958 |
Management of the narcotic withdrawal syndrome in the neonate.
Topics: Barbiturates; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exc | 1963 |
CONGENITAL NEONATAL NARCOTICS ADDICTION: A NATURAL HISTORY.
Topics: Chlorpromazine; Female; Humans; Maternal-Fetal Exchange; Meperidine; Methadone; Morphine Dependence; | 1964 |
[Painless labor with polamidone S..].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Female; Humans; Labor, Obstetric; Methadone; Pain M | 1954 |
Maternal methadone dose and neonatal withdrawal.
Topics: Benzodiazepines; Dose-Response Relationship, Drug; Female; Heroin Dependence; Humans; Infant, Newbor | 2003 |
Impact of methadone program philosophy changes on early treatment outcomes.
Topics: Adult; Clinical Protocols; Cohort Studies; Cross-Sectional Studies; Dose-Response Relationship, Drug | 2003 |
Specialized drug liaison midwife services for pregnant opioid dependent women in Dublin, Ireland.
Topics: Adult; Crime; Female; Humans; Infant, Newborn; Ireland; Mental Disorders; Methadone; Midwifery; Narc | 2004 |
Outcomes of infants born to mothers receiving methadone for pain management in pregnancy.
Topics: Analgesics, Opioid; Chronic Disease; Delivery, Obstetric; Drug Administration Schedule; Female; Gest | 2004 |
Use of methadone-scopolamine in obstetric analgesia.
Topics: Analgesia, Obstetrical; Female; Humans; Labor, Obstetric; Methadone; Pregnancy; Scopolamine; Work | 1952 |
[Polamidon C in obstetrics].
Topics: Female; Humans; Labor, Obstetric; Methadone; Obstetrics; Pregnancy; Work | 1952 |
["Is opiate detoxification unsafe in pregnancy?"].
Topics: Adult; Female; Humans; Infant, Newborn; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy; P | 2004 |
Methadone maintenance vs. implantable naltrexone treatment in the pregnant heroin user.
Topics: Australia; Drug Implants; Female; Heroin Dependence; Humans; Methadone; Naltrexone; Narcotic Antagon | 2004 |
Does pregnancy affect outcome of methadone maintenance treatment?
Topics: Adult; Case-Control Studies; Comorbidity; Female; Heroin Dependence; Humans; Mental Disorders; Metha | 2004 |
French field experience with buprenorphine.
Topics: Adult; Buprenorphine; Cause of Death; Cross-Cultural Comparison; Drug Approval; Drug Overdose; Drug | 2004 |
Methadone metabolism by human placenta.
Topics: Analgesics, Opioid; Aromatase; DNA, Complementary; Estradiol; Female; Humans; Kinetics; Methadone; M | 2004 |
Differential effects of gestational buprenorphine, naloxone, and methadone on mesolimbic mu opioid and ORL1 receptor G protein coupling.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Autoradiography; Buprenorphine; Dose-Response Relatio | 2004 |
Impact of spinal anaesthesia and obesity on maternal respiratory function during elective Caesarean section.
Topics: Adult; Analgesics, Opioid; Anesthesia, Obstetrical; Anesthesia, Spinal; Body Mass Index; Cesarean Se | 2004 |
Neonatal abstinence syndrome in methadone-exposed infants is altered by level of prenatal tobacco exposure.
Topics: Adult; Analysis of Variance; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrom | 2004 |
Improving the management of opioid-dependent pregnancies.
Topics: Cohort Studies; Dose-Response Relationship, Drug; Female; Gestational Age; Humans; Infant, Newborn; | 2004 |
Can methadone concentrations predict the severity of withdrawal in infants at risk of neonatal abstinence syndrome?
Topics: Adult; Drug Administration Schedule; Female; Fetal Blood; Humans; Infant, Newborn; Male; Maternal-Fe | 2004 |
Bidirectional transfer of methadone across human placenta.
Topics: Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Maternal-Fetal Exchange; Meth | 2005 |
Challenges that opioid-dependent women present to the obstetric anaesthetist.
Topics: Adult; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Anesthesia, Obstetrical; Cesarean Sect | 2004 |
Methadone maintenance program in a Swiss perinatal center: (I): Management and outcome of 89 pregnancies.
Topics: Adult; Birth Weight; Cocaine-Related Disorders; Cohort Studies; Dose-Response Relationship, Drug; Dr | 2005 |
Methadone maintenance program in pregnancy in a Swiss perinatal center (II): neonatal outcome and social resources.
Topics: Adult; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fetal | 2005 |
Secondary amenorrhea: an unusual twist.
Topics: Adolescent; Amenorrhea; Clitoris; Female; Humans; Methadone; Narcotics; Pregnancy; Prenatal Exposure | 2005 |
Role of P-glycoprotein in transplacental transfer of methadone.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Dose-Response Relationship, Drug | 2005 |
Attitudes and practices regarding the use of methadone in US state and federal prisons.
Topics: Drug Utilization; Federal Government; Female; Humans; Male; Methadone; Narcotics; Opioid-Related Dis | 2005 |
High-dose methadone maintenance in pregnancy: maternal and neonatal outcomes.
Topics: Adult; Analgesics, Opioid; Female; Gestational Age; Humans; Infant, Newborn; Length of Stay; Methado | 2005 |
Fetal response to maternal methadone administration.
Topics: Adult; Analgesics, Opioid; Female; Fetal Movement; Fetus; Heart Rate, Fetal; Humans; Male; Methadone | 2005 |
Fetal response to maternal methadone administration.
Topics: Adult; Analgesics, Opioid; Female; Fetal Movement; Fetus; Heart Rate, Fetal; Humans; Male; Methadone | 2005 |
Fetal response to maternal methadone administration.
Topics: Adult; Analgesics, Opioid; Female; Fetal Movement; Fetus; Heart Rate, Fetal; Humans; Male; Methadone | 2005 |
Fetal response to maternal methadone administration.
Topics: Adult; Analgesics, Opioid; Female; Fetal Movement; Fetus; Heart Rate, Fetal; Humans; Male; Methadone | 2005 |
Pregnancy outcome in women who use opiates.
Topics: Adult; England; Female; Heroin; Humans; Infant, Newborn; Male; Medical Records; Methadone; Neonatal | 2006 |
Prospective multicenter observational study of 260 infants born to 259 opiate-dependent mothers on methadone or high-dose buprenophine substitution.
Topics: Adult; Buprenorphine; Female; HIV Seropositivity; Humans; Infant Care; Infant, Newborn; Methadone; N | 2006 |
Changes to methadone clearance during pregnancy.
Topics: Adolescent; Adult; Area Under Curve; Chromatography, High Pressure Liquid; Female; Heroin; Heroin De | 2005 |
Mothers in substance abuse treatment: differences in characteristics based on involvement with child welfare services.
Topics: Adolescent; Adult; Alcoholism; Ambulatory Care; Amphetamine-Related Disorders; California; Child; Ch | 2006 |
Effect of chronic maternal methadone therapy on intrapartum fetal heart rate patterns.
Topics: Adult; Cohort Studies; Ethnicity; Female; Gestational Age; Heart Rate, Fetal; Humans; Methadone; Opi | 2006 |
Buprenorphine replacement therapy: a confirmed benefit.
Topics: Benzodiazepines; Buprenorphine; Cohort Studies; Drug Therapy, Combination; Female; France; Heroin De | 2006 |
[A multidisciplinary approach is necessary in the neonatal withdrawal syndrome].
Topics: Adult; Female; Humans; Hypnotics and Sedatives; Infant, Newborn; Male; Methadone; Narcotics; Neonata | 2006 |
Gender differences and pregnant women in a methadone maintenance treatment (MMT) clinic.
Topics: Adult; Age Factors; Cocaine-Related Disorders; Cohort Studies; Comorbidity; Emigration and Immigrati | 2006 |
Methadone metabolism by early gestational age placentas.
Topics: Aromatase; Female; Gestational Age; Humans; In Vitro Techniques; Methadone; Microsomes; Narcotics; P | 2006 |
The effect of maternal methadone use on the fetal heart pattern: a computerised CTG analysis.
Topics: Adult; Cardiotocography; Diagnosis, Computer-Assisted; Female; Heart Rate, Fetal; Humans; Methadone; | 2006 |
A chart review comparing paregoric to methadone in the treatment of neonatal opioid withdrawal.
Topics: Analgesics, Opioid; Documentation; Drug Administration Schedule; Female; Humans; Infant, Newborn; Ma | 2006 |
Substance abuse in pregnancy: opioid substitution in a northern Ireland maternity unit.
Topics: Adult; Buprenorphine; Codeine; Female; Heroin Dependence; Humans; Infant, Newborn; Maternal-Fetal Ex | 2006 |
Depression in methadone maintenance treatment patients: rate and risk factors.
Topics: Adult; Benzodiazepines; Brief Psychiatric Rating Scale; Cocaine; Cocaine-Related Disorders; Comorbid | 2007 |
Mood disorders affect drug treatment success of drug-dependent pregnant women.
Topics: Adult; Diagnosis, Dual (Psychiatry); Diagnostic and Statistical Manual of Mental Disorders; Female; | 2007 |
Methadone in pregnancy: treatment retention and neonatal outcomes.
Topics: Adult; Female; Humans; Infant, Newborn; Infant, Premature; Infant, Small for Gestational Age; Methad | 2007 |
Methadone-exposed newborn infants: outcome after alterations to a service for mothers and infants.
Topics: Delivery of Health Care; Female; Humans; Infant Care; Infant, Newborn; Interprofessional Relations; | 2007 |
[Drugs, pregnancy and newborn infants from the viewpoint of pediatric nursing].
Topics: Breast Feeding; Education; Female; Humans; Infant, Newborn; Male; Methadone; Mother-Child Relations; | 2002 |
Maternal methadone may cause arrhythmias in neonates.
Topics: Electrocardiography; Female; Humans; Infant, Newborn; Long QT Syndrome; Methadone; Narcotics; Pregna | 2007 |
Concentrations of methadone in breast milk and plasma in the immediate perinatal period.
Topics: Adult; Analgesics, Opioid; Female; Humans; Infant, Newborn; Male; Methadone; Milk, Human; Postpartum | 2007 |
Sequela of preterm versus term infants born to mothers on a methadone maintenance program: differential course of neonatal abstinence syndrome.
Topics: Cohort Studies; Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Methadone; Narc | 2007 |
Variability in the evaluation and management of opiate-exposed newborns in Maryland.
Topics: Adolescent; Adult; Data Collection; Female; Humans; Infant, Newborn; Maryland; Methadone; Neonatal A | 2007 |
Intrapartum and postpartum analgesia for women maintained on methadone during pregnancy.
Topics: Adolescent; Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Case-Control Studies; Cesarean | 2007 |
Using population data to examine the prevalence and correlates of neonatal abstinence syndrome.
Topics: Adult; Cross-Sectional Studies; Databases, Factual; Female; Gravidity; Humans; Infant, Newborn; Inte | 2007 |
Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)- and racemic-methadone.
Topics: Adult; Alleles; Analgesics, Opioid; Cytochrome P-450 CYP2D6; Female; Genotype; Humans; Male; Methado | 2007 |
Rooming-in compared with standard care for newborns of mothers using methadone or heroin.
Topics: Adult; Breast Feeding; British Columbia; Child Custody; Cohort Studies; Comorbidity; Female; Heroin; | 2007 |
[The effect of substitution therapy on the birth weight of the newborn, its postpartum adaptation, trophic and course of the neonatal abstinence syndrome].
Topics: Apgar Score; Birth Weight; Buprenorphine; Female; Fetal Growth Retardation; Heroin Dependence; Human | 2007 |
Hospital morphine preparation for abstinence syndrome in newborns exposed to buprenorphine or methadone.
Topics: Buprenorphine; Chromatography, High Pressure Liquid; Drug Contamination; Drug Stability; Female; Hum | 2008 |
Outcomes of neonates conceived on methadone maintenance therapy.
Topics: Adult; Analgesics, Opioid; Birth Weight; Female; Follow-Up Studies; Gestational Age; Humans; Infant, | 2008 |
Transfer of methadone across the dually perfused preterm human placental lobule.
Topics: Female; Gestational Age; Humans; Maternal-Fetal Exchange; Methadone; Organ Culture Techniques; Perfu | 2008 |
Methadone maintenance and breastfeeding in the neonatal period.
Topics: Adult; Bottle Feeding; Breast Feeding; Case-Control Studies; Cohort Studies; Dose-Response Relations | 2008 |
Visual evoked potentials in infants exposed to methadone in utero.
Topics: Case-Control Studies; Child Development; Evoked Potentials, Visual; Female; Humans; Infant, Newborn; | 2008 |
Buprenorphine and methadone treatment of opiate dependence during pregnancy: comparison of fetal growth and neonatal outcomes in two consecutive case series.
Topics: Birth Weight; Buprenorphine; Female; Fetal Growth Retardation; Heroin Dependence; Humans; Infant Mor | 2008 |
Methadone maintenance and breastfeeding in the neonatal period.
Topics: Bottle Feeding; Breast Feeding; Dose-Response Relationship, Drug; Drug Administration Schedule; Fema | 2008 |
Oxygen consumption in the new-born rat and the effects of maternally administered analgesics.
Topics: Analgesics; Animals; Animals, Newborn; Female; Maternal-Fetal Exchange; Meperidine; Methadone; Morph | 1967 |
Narcotics and medical practice. Medical use of morphine and morphine-like drugs and management of persons dependent on them.
Topics: Amphetamine; Barbiturates; Cannabis; Drug and Narcotic Control; Female; Heroin; Humans; Legislation, | 1967 |
Delays in growth and biochemical development of rat brain caused by maternal methadone administration: are the alterations in synaptogenesis and cellular maturation independent of reduced maternal food intake?
Topics: Aging; Animals; Body Weight; Brain; Eating; Female; Methadone; Organ Size; Ornithine Decarboxylase; | 1982 |
Chronic use of opioids and antipsychotic drugs: side effects, effects on endogenous opioids, and toxicity.
Topics: Adolescent; Adult; Animals; Antipsychotic Agents; Blood Proteins; Endorphins; Female; Humans; Liver | 1982 |
Analgesic effect of opiates in offspring of opiate-treated female rats.
Topics: Analgesics, Opioid; Animals; Female; Male; Methadone; Morphine; Pregnancy; Prenatal Exposure Delayed | 1984 |
Follow-up of methadone-treated and untreated narcotic-dependent women and their infants: health, developmental, and social implications.
Topics: Adult; Developmental Disabilities; Female; Follow-Up Studies; Health Status; Humans; Infant; Infant, | 1981 |
Children of methadone-maintained mothers: follow-up to 18 months of age.
Topics: Abnormalities, Drug-Induced; Developmental Disabilities; Female; Follow-Up Studies; Humans; Infant; | 1982 |
Maturation of sympathetic neurotransmission in the rat heart. I. Ontogeny of the synaptic vesicle uptake mechanism and correlation with development of synaptic function. Effects of neonatal methadone administration on development of synaptic vesicles.
Topics: Adrenergic Fibers; Age Factors; Animals; Female; Heart; Heart Rate; Methadone; Norepinephrine; Pregn | 1980 |
Urinary catecholamines, plasma renin activity and blood pressure in newborns: effects of narcotic withdrawal.
Topics: Catecholamines; Diastole; Female; Heroin; Humans; Hypertension; Infant, Newborn; Infant, Newborn, Di | 1981 |
Maternal methadone administration: deficit in development of alpha-noradrenergic responses in developing rat brain as assessed by norepinephrine stimulation of 33Pi incorporation into phospholipids in vivo.
Topics: Animals; Animals, Newborn; Brain; Female; Maternal-Fetal Exchange; Methadone; Norepinephrine; Phosph | 1982 |
Evidence for hormonal imbalance after methadone treatment in pregnant and pseudopregnant rats.
Topics: Adrenal Glands; Animals; Cyclic AMP; Cyclic GMP; Estriol; Female; Fetus; Gestational Age; Methadone; | 1983 |
In utero exposure to methadone produces a stable decrease of the cortex 5-HT transport system in rats.
Topics: Animals; Biological Transport; Cerebral Cortex; Female; Imipramine; Methadone; Naloxone; Pregnancy; | 1983 |
Acute and subchronic effects of methadone on the blood hormonal levels of pregnant and nonpregnant Charles River CD-1 mice.
Topics: Adrenocorticotropic Hormone; Animals; Estriol; Estrus; Female; Follicle Stimulating Hormone; Gestati | 1983 |
Somatic and neurobiological alterations in the progeny of female rats treated with methadone prior to mating.
Topics: Animals; Body Weight; Brain; Cerebellum; Female; Male; Methadone; Organ Size; Pregnancy; Prenatal Ex | 1983 |
Motoric and attentional behavior in infants of methadone-maintained women.
Topics: Aging; Attention; Behavior; Female; Humans; Infant; Male; Methadone; Motor Activity; Opioid-Related | 1983 |
Prevalence and implications of multi-drug abuse in a population of methadone-maintained women.
Topics: Amphetamine; Diazepam; Female; Heroin; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregn | 1983 |
Perinatal addiction: the effects of maternal narcotic and nonnarcotic substance abuse on the fetus and neonate.
Topics: Adult; Arousal; Birth Weight; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, D | 1984 |
Fetal breathing movements and the response to carbon dioxide in patients on methadone maintenance.
Topics: Carbon Dioxide; Female; Fetus; Humans; Methadone; Movement; Opioid-Related Disorders; Pregnancy; Pre | 1984 |
A longitudinal study of offspring born to methadone-maintained women. I. Design, methodology, and description of women's resources for functioning.
Topics: Adolescent; Adult; Child Behavior; Child Development; Cognition; Family; Female; Follow-Up Studies; | 1984 |
A longitudinal study of offspring born to methadone-maintained women. II. Dyadic interaction and infant behavior at 4 months.
Topics: Child Behavior; Child Development; Cognition; Communication; Female; Follow-Up Studies; Heroin Depen | 1984 |
A longitudinal study of offspring born to methadone-maintained women. III. Effects of multiple risk factors on development at 4, 8, and 12 months.
Topics: Attention; Child Behavior; Child Development; Female; Follow-Up Studies; Heroin Dependence; Humans; | 1984 |
The Moro reaction: a scoring system for neonatal narcotic withdrawal.
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Pregnancy; Reflex, Startle; S | 1984 |
Dyads at risk: methadone-maintained women and their four-month-old infants.
Topics: Adolescent; Adult; Female; Humans; Infant; Longitudinal Studies; Maternal Behavior; Methadone; Mothe | 1984 |
Chronic maternal methadone exposure and response to analgesics.
Topics: Analgesics; Animals; Brain Chemistry; Female; Male; Methadone; Pregnancy; Prenatal Exposure Delayed | 1984 |
Neonatal opiate withdrawal alters the reactivity of adult rats to the hot-plate.
Topics: Animals; Dose-Response Relationship, Drug; Escape Reaction; Female; Humans; Male; Methadone; Methady | 1984 |
The sequelea to addiction.
Topics: Female; Fetal Alcohol Spectrum Disorders; Fetal Diseases; Heroin; Humans; Methadone; Opioid-Related | 1983 |
Methadone affects the histochemical pattern of xenobiotic-metabolizing enzymes in the liver of pregnant rats.
Topics: Animals; Female; Histocytochemistry; Liver; Methadone; Mixed Function Oxygenases; Pregnancy; Rats; R | 1984 |
Drug addiction during pregnancy.
Topics: Birth Weight; Delivery, Obstetric; Female; Fetal Monitoring; Follow-Up Studies; Heroin; Heroin Depen | 1983 |
Fate of tritium derived from prenatally administered tritiated methadone in dams and neonatal rats.
Topics: Animals; Animals, Newborn; Brain; Female; Liver; Maternal-Fetal Exchange; Methadone; Pregnancy; Rats | 1983 |
Coordination of services to methadone mothers and their addicted newborns.
Topics: Child Abuse; Child Welfare; Child, Preschool; Female; Hospital Departments; Humans; Infant; Infant, | 1983 |
Effects of opiates on fetal behavioral activity in utero.
Topics: Animals; Blood Pressure; Female; Fetal Heart; Fetus; Heart Rate; Maternal-Fetal Exchange; Methadone; | 1983 |
Separation of hepatic N-demethylase-inducing and opioid dependence-producing doses of levo-alpha-acetylmethadol in the pregnant rat.
Topics: Animals; Animals, Newborn; Body Weight; Dose-Response Relationship, Drug; Embryo Implantation; Ethyl | 1983 |
Human garbage and physical garbage: a sociological case example of institutional violence.
Topics: Adult; Aged; Delivery of Health Care; Female; Garbage; Humans; Institutional Practice; Israel; Male; | 1984 |
A comprehensive care program for pregnant addicts: obstetrical, neonatal, and child development outcomes.
Topics: Adult; Birth Weight; Child Development; Counseling; Delivery, Obstetric; Female; Gestational Age; He | 1984 |
Ventilatory response to carbon dioxide of infants following chronic prenatal methadone exposure.
Topics: Carbon Dioxide; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Methadone; Oxygen; Partial | 1980 |
A quantitative evaluation of fetal growth failure in a drug-abusing population.
Topics: Abnormalities, Drug-Induced; Female; Fetal Growth Retardation; Gestational Age; Humans; Methadone; P | 1981 |
Altered respiratory control in newborn puppies after chronic prenatal exposure to alpha-1-acetylmethadol (LAAM).
Topics: Animals; Animals, Newborn; Carbon Dioxide; Chloral Hydrate; Dogs; Female; Humans; Methadone; Methady | 1982 |
Differential motor and state functioning in newborns of women on methadone.
Topics: Adolescent; Adult; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Pregnancy; | 1982 |
The effects of perinatal addiction on pulmonary function in the newborn.
Topics: Birth Weight; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lung; M | 1982 |
Disposition of maternally-administered methadone and its effects on hepatic drug-metabolizing functions in perinatal guinea pigs.
Topics: Aging; Animals; Animals, Newborn; Blood Proteins; Female; Glucuronosyltransferase; Guinea Pigs; Live | 1982 |
The emergence of maternal drug addiction as a problem in Ireland 1981.
Topics: Adolescent; Adult; Cesarean Section; Female; Heroin; Humans; Infant, Newborn; Ireland; Male; Materna | 1983 |
Fetal and postnatal growth of children born to narcotic-dependent women.
Topics: Body Height; Female; Fetus; Growth; Heroin Dependence; Humans; Infant, Newborn; Longitudinal Studies | 1983 |
[Condition of 89 newborn infants of drug-addicted mothers].
Topics: Abnormalities, Drug-Induced; Adult; Apgar Score; Female; Heroin Dependence; Humans; Infant, Low Birt | 1983 |
Parental methadone treatment: a multigenerational study of development and behavior in offspring.
Topics: Animals; Behavior, Animal; Birth Weight; Body Weight; Brain; Female; Growth; Growth Disorders; Human | 1983 |
Pentazocine and tripelennamine ('T's and blue's'): effects on the fetus and neonate.
Topics: Adult; Female; Fetus; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Opioid-Related | 1983 |
Developmental toxic effect after subcutaneous injections of methadone in Charles River CD-1 mice.
Topics: Animals; Body Weight; Feeding Behavior; Female; Fetus; Growth; Injections, Subcutaneous; Male; Metha | 1983 |
Investigation of 89 children born by drug-dependent mothers. I. Neonatal course.
Topics: Adult; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Infant, Small | 1983 |
Investigation of 89 children born by drug-dependent mothers. II. Follow-up 1-10 years after birth.
Topics: Adult; Child; Child Behavior Disorders; Child, Institutionalized; Child, Preschool; Female; Follow-U | 1983 |
Postnatal abstinence or acute toxicity can account for morbidity in developmental studies with opiates.
Topics: Animals; Animals, Newborn; Body Weight; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; | 1983 |
Influence of concurrent testosterone on the effects of methadone on male rats and their progeny.
Topics: Animals; Birth Weight; Body Weight; Female; Fetus; Genitalia, Male; Litter Size; Male; Methadone; Pr | 1980 |
Isotope dilution technique for the estimation of l-alpha-[2-3H]-acetylmethadol and its metabolites in biological samples.
Topics: Animals; Biotransformation; Chromatography, Gas; Chromatography, Thin Layer; Female; Liver; Methadon | 1980 |
Precocious development of sympatho-adrenal function in rats whose mothers received methadone.
Topics: Adrenal Glands; Animals; Catecholamines; Female; Insulin; Maternal-Fetal Exchange; Methadone; Pregna | 1980 |
Duration of thrombocytosis in infants of polydrug (including methadone) users.
Topics: Female; Humans; Infant; Infant, Newborn; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy C | 1982 |
Cumulation of active metabolites of levo-alpha-acetylmethadol in the rat fetus and neonate.
Topics: Animals; Animals, Newborn; Brain; Female; Fetus; Maternal-Fetal Exchange; Methadone; Methadyl Acetat | 1982 |
Ritalin: consequences of abuse in a clinical population.
Topics: Adult; Female; Humans; Injections, Intravenous; Male; Methadone; Methylphenidate; Opioid-Related Dis | 1982 |
The relationship between maternal and fetal plasma protein binding of methadone in the ewe during the third trimester.
Topics: Animals; Blood Proteins; Female; Fetus; Gestational Age; Maternal-Fetal Exchange; Methadone; Pregnan | 1982 |
A comparison of morphine and methadone disposition in the maternal-fetal unit.
Topics: Animals; Female; Fetus; Gestational Age; Maternal-Fetal Exchange; Metabolic Clearance Rate; Methadon | 1982 |
Methadone outcome studies: is it more than the methadone?
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Met | 1982 |
Polydrug- and methadone-addicted newborns: a continuum of impairment?
Topics: Abnormalities, Drug-Induced; Birth Weight; Child Behavior; Female; Heroin Dependence; Humans; Infant | 1982 |
The Northwestern University Drug Dependence Program: the impact of intensive prenatal care on labor and delivery outcomes.
Topics: Adult; Apgar Score; Birth Weight; Cephalometry; Counseling; Female; Fetus; Gestational Age; Humans; | 1982 |
Some effects of maternal drug addiction on the neonate.
Topics: Arousal; Child Behavior; Female; Habituation, Psychophysiologic; Heroin; Humans; Infant, Newborn; Ma | 1982 |
Neuronal cell deficits following exposure to methadone in rats.
Topics: Animals; Cell Count; Cerebellum; Female; Lactation; Maternal-Fetal Exchange; Methadone; Neurons; Pre | 1982 |
Infants born to narcotic-addicted mothers.
Topics: Child Development; Female; Heroin; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Metha | 1982 |
Norepinephrine content of the rat kidney during development: alterations induced by perinatal methadone.
Topics: Animals; Animals, Newborn; Body Weight; Female; Kidney; Methadone; Norepinephrine; Organ Size; Pregn | 1982 |
Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment.
Topics: Aging; Animals; Animals, Newborn; Female; Heart; Methadone; Myocardium; Ornithine Decarboxylase; Pol | 1982 |
Effects of methadone on thyroid function in mother, fetus, and newborn.
Topics: Adolescent; Adult; Age Factors; Female; Fetal Blood; Humans; Infant, Newborn; Infant, Newborn, Disea | 1980 |
Sudden infant death.
Topics: Adipose Tissue; Adipose Tissue, Brown; Carotid Body; Erythrocytes, Abnormal; Female; Humans; Hypoxia | 1980 |
Fetal exposure to narcotics: neonatal sleep as a measure of nervous system disturbance.
Topics: Birth Weight; Female; Heroin; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; | 1980 |
Methadone exposure in utero: effects on open-field activity in weanling rats.
Topics: Animals; Animals, Suckling; Birth Weight; Dose-Response Relationship, Drug; Exploratory Behavior; Fe | 1980 |
Methadone binding to orosomucoid (alpha 1-acid glycoprotein): determinant of free fraction in plasma.
Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Lipoproteins; Metabolic Clearance Rate; Methadone; Mid | 1981 |
Opiate withdrawal in utero increases neonatal morbidity in the rat.
Topics: Animals; Drug Tolerance; Embryo Implantation; Female; Fetal Death; Humans; Litter Size; Methadone; M | 1981 |
Outcome of pregnancy in rats chronically exposed to 1-alpha-acetylmethadol (LAAM).
Topics: Animals; Animals, Newborn; Birth Weight; Body Weight; Female; Humans; Methadone; Methadyl Acetate; O | 1981 |
Methadone exposure in utero: effects on brain biogenic amines and behavior.
Topics: Animals; Avoidance Learning; Behavior, Animal; Biogenic Amines; Brain Chemistry; Catecholamines; Dop | 1980 |
Withdrawal-like symptoms in young and adult rats maternally exposed to methadone.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Body Temperature Regulation; Body Weight; | 1981 |
[Pregnancy in heroin addiction; an 11-year survey at the Wilhelmina Gasthuis in Amsterdam].
Topics: Female; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn; Infant, Premature; Infant, Sma | 1982 |
Moods of pregnant and nonpregnant heroin addicts.
Topics: Adult; Affect; Female; Heroin Dependence; Humans; Methadone; Pregnancy | 1980 |
[Neonatal withdrawal syndrome 2 cases of newborn infants of drug-addicted mothers].
Topics: Adult; Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Pregnancy; Substance Withdrawa | 1980 |
Respiratory and hemodynamic effects of methadone in pregnant women.
Topics: Blood Pressure; Female; Heroin Dependence; Humans; Mathematics; Methadone; Oxygen Consumption; Physi | 1980 |
Disposition of methadone in the ovine maternal-fetal unit.
Topics: Animals; Female; Maternal-Fetal Exchange; Methadone; Pregnancy; Sheep | 1981 |
Heroin addiction and pregnancy.
Topics: Animals; Female; Fetal Diseases; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseas | 1981 |
Enhanced sensitivity to methadone in adult rats perinatally exposed to methadone.
Topics: Animals; Body Temperature Regulation; Body Weight; Female; Lactation; Methadone; Nociceptors; Pregna | 1981 |
Alterations in the development of catecholamine turnover induced by perinatal methadone: differences in central vs. peripheral sympathetic nervous systems.
Topics: Animals; Brain; Catecholamines; Central Nervous System; Female; Kinetics; Methadone; Myocardium; Per | 1981 |
The Neonatal Narcotic Withdrawal Index: a device for the improvement of care in the abstinence syndrome.
Topics: Female; Heroin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Opium; Pregnancy; Psy | 1981 |
Relationship of thyroid hormone levels to the severity of the narcotic withdrawal syndrome.
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Pregnancy; Prospective | 1981 |
[Newborn neonatal drug-withdrawal syndrome].
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Methadone; Opiu | 1981 |
Protracted analgesia in young and adult rats maternally exposed to methadone.
Topics: Age Factors; Analgesia; Animals; Female; Male; Maternal-Fetal Exchange; Methadone; Pregnancy; Rats; | 1980 |
Effects of maternal methadone administration on ornithine decarboxylase in brain and heart of the offspring: relationships of enzyme activity to dose and to growth impairment in the rat.
Topics: Animals; Body Weight; Brain; Carboxy-Lyases; Female; Heart; Maternal-Fetal Exchange; Methadone; Myoc | 1980 |
[Jaundice in the newborn infant of a "poly-drug-dependent" mother. Heroin and methadone, G6PDH deficiency and antagonism in the enzymatic modulation].
Topics: Adult; Drug Antagonism; Female; Glucosephosphate Dehydrogenase Deficiency; Heroin Dependence; Humans | 1980 |
Effect of methadone treatment during pregnancy on the fetal testes and hypothalamus in rats.
Topics: Androstenedione; Animals; Female; Fetal Blood; Fetus; Hypothalamus; Male; Methadone; Naloxone; Pregn | 1980 |
Thrombocytosis in the offspring of female mice receiving DL-methadone.
Topics: Animals; Animals, Newborn; Bone Marrow Cells; Disease Models, Animal; Female; Hematopoiesis; Megakar | 1980 |
Body and organ development of young rats maternally exposed to methadone.
Topics: Animals; Body Weight; Female; Fetus; Lactation; Male; Maternal-Fetal Exchange; Methadone; Organ Size | 1980 |
Effect of maternally administered methadone on discrimination learning of rat offspring.
Topics: Animals; Discrimination Learning; Female; Male; Maternal-Fetal Exchange; Methadone; Pregnancy; Rats | 1980 |
Early growth patterns of methadone-addicted infants.
Topics: Adult; Female; Follow-Up Studies; Growth; Humans; Infant, Newborn; Methadone; Pregnancy; Substance W | 1980 |
Effects of prenatal methadone on rat brain catecholamines.
Topics: Animals; Body Weight; Brain; Catecholamines; Dopamine; Female; Gestational Age; Kinetics; Male; Meth | 1980 |
Developmental outcomes of children of mothers dependent on heroin or heroin/methadone during pregnancy.
Topics: Child; Child of Impaired Parents; Child, Preschool; Cross-Sectional Studies; Developmental Disabilit | 1994 |
Development after prenatal exposure to cocaine, heroin and methadone.
Topics: Case-Control Studies; Child; Child of Impaired Parents; Child, Preschool; Cocaine; Developmental Dis | 1994 |
Prenatal care of HIV-infected women: analysis of a large New York State cohort.
Topics: Adolescent; Adult; Cohort Studies; Female; HIV Infections; Humans; Infectious Disease Transmission, | 1995 |
Decreased maternal-fetal attachment in methadone-maintained pregnant women: a preliminary study.
Topics: Adolescent; Adult; Case-Control Studies; Cross-Sectional Studies; Female; Humans; Methadone; Mother- | 1995 |
[Withdrawal syndrome in a newborn infant born to an addicted mother receiving methadone].
Topics: Adult; Female; Heroin Dependence; Humans; Infant, Newborn; Male; Methadone; Neonatal Abstinence Synd | 1995 |
Maternal methadone dosage and neonatal withdrawal.
Topics: Birth Weight; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Methadone; Neonatal | 1995 |
Children of methadone-dependent women: developmental outcomes.
Topics: Affective Symptoms; Child; Child Behavior Disorders; Child, Preschool; Developmental Disabilities; E | 1993 |
Opioid tolerance in human placenta due to in vitro methadone administration.
Topics: Chorionic Gonadotropin; Culture Techniques; Drug Tolerance; Female; Humans; Methadone; Narcotics; Pl | 1995 |
Methadone maintenance treatment. Pregnant women taking methadone should be warned about withdrawal symptoms in babies.
Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Patient | 1995 |
[Substitution treatments in Geneva].
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Family; Female; HIV Infections; Humans; Male; | 1994 |
[Report on the methadone program at the Centre Pierre-Nicole].
Topics: Acquired Immunodeficiency Syndrome; Adult; Female; Heroin Dependence; Humans; Male; Methadone; Middl | 1994 |
Methadone levels in plasma, urine, and amniotic fluid of methadone-treated pregnant rats.
Topics: Amniotic Fluid; Animals; Biotransformation; Chromatography, High Pressure Liquid; Emulsions; Female; | 1994 |
The drugs in pregnancy service.
Topics: Acquired Immunodeficiency Syndrome; Female; Health Behavior; HIV Infections; Humans; Infant, Newborn | 1995 |
Cognitive development at preschool-age of infants of drug-dependent mothers.
Topics: Child, Preschool; Cocaine; Cognition; Female; Heroin; Humans; Infant; Infant, Newborn; Language; Mal | 1994 |
[Neonatal abstinence syndrome and maternal toxicological profile].
Topics: Dose-Response Relationship, Drug; Female; Gestational Age; Heroin; Humans; Infant, Newborn; Maternal | 1994 |
Children of substance abusers: the life experiences of children of opiate addicts in methadone maintenance.
Topics: Adolescent; Adult; Antisocial Personality Disorder; Bipolar Disorder; Child; Child Abuse; Child Abus | 1994 |
Biliary atresia, intestinal malrotation, partial abdominal heterotaxia, and craniofacial anomalies in a newborn with intrauterine opiate exposure.
Topics: Abdomen; Abnormalities, Drug-Induced; Biliary Atresia; Cleft Lip; Cleft Palate; Female; Heroin; Huma | 1994 |
Methadone therapy.
Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Pregnan | 1993 |
HIV infection and the meaning of condoms.
Topics: Acquired Immunodeficiency Syndrome; Adult; Condoms; Female; Gender Identity; Health Knowledge, Attit | 1993 |
A comparison of meconium, maternal urine and neonatal urine for detection of maternal drug use during pregnancy.
Topics: Adult; Cocaine; Dronabinol; Female; Gas Chromatography-Mass Spectrometry; Humans; Illicit Drugs; Imm | 1994 |
[Pregnancy test falsely positive from methadone].
Topics: Adult; False Positive Reactions; Female; Humans; Methadone; Pregnancy; Pregnancy Tests | 1994 |
Prenatal exposure to methadone delays the development of striatal cholinergic neurons.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Cell Size; Cellular Senescence; Choline O-Acetyltransf | 1993 |
Study of 45 pregnant opiate addicts in Dublin.
Topics: Adult; Child Welfare; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Ireland; Life Styl | 1993 |
Relationship of maternal substance abuse to subsequent sudden infant death syndrome in offspring.
Topics: Adult; Age Factors; Chi-Square Distribution; Cocaine; Confidence Intervals; Female; Heroin; Humans; | 1993 |
[The consequences for the child of drug addiction in the mother: current status in relation to knowledge and management policy in The Netherlands].
Topics: Child Development; Child, Preschool; Female; Humans; Infant; Infant Care; Infant, Newborn; Methadone | 1993 |
[Neonatal abstinence syndrome: current and future aspects].
Topics: Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Opium; Parasympatholytics; | 1993 |
Relationship between maternal methadone dosage, maternal-neonatal methadone levels, and neonatal withdrawal.
Topics: Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Pregnancy; Pregnancy Compl | 1993 |
Perinatal methadone exposure produces physical dependence and altered behavioral development in the rat.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Weight; Drinking; Eating; Female; Male; Methad | 1996 |
Methadone use during pregnancy.
Topics: Animals; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinence Syndrome; Pregna | 1995 |
Perinatal exposure to methadone affects central cholinergic activity in the weanling rat.
Topics: Acetylcholine; Animals; Animals, Newborn; Brain; Brain Mapping; Female; Humans; Infant, Newborn; Mal | 1996 |
Neonatal withdrawal syndrome in infants exposed to cocaine and methadone.
Topics: Cocaine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Neurologic Examin | 1996 |
Effects of prenatal exposure to opioids on focused attention in toddlers during free play.
Topics: Attention; Child, Preschool; Female; Heroin; Heroin Dependence; Humans; Male; Methadone; Mother-Chil | 1996 |
Postnatal methadone exposure doe not prevent prenatal methadone-induced changes in striatal cholinergic neurons.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; Animals; Dopamine; Female; Hydroxyindoleacetic Acid; | 1996 |
Association of maternal drug use during pregnancy with maternal HIV culture positivity and perinatal HIV transmission.
Topics: Alcohol Drinking; Cocaine; Cohort Studies; Female; Heroin; HIV Infections; HIV-1; Humans; Infant; In | 1996 |
Effect of methadone on the biophysical profile.
Topics: Adult; Circadian Rhythm; Female; Fetal Movement; Heart Rate, Fetal; Humans; Methadone; Opioid-Relate | 1996 |
[Pregnancy and drug dependence].
Topics: Administration, Oral; Adult; Austria; Delayed-Action Preparations; Dose-Response Relationship, Drug; | 1996 |
Assessment of fetal well-being in methadone-maintained pregnancies: abnormal nonstress tests.
Topics: Abnormalities, Drug-Induced; Adult; Analgesics, Opioid; Case-Control Studies; Exercise Test; Female; | 1997 |
Association of maternal drug use during pregnancy with mother-to-child HIV transmission. New York City Perinatal HIV Transmission Collaborative Study.
Topics: Cocaine; Female; Heroin; HIV Infections; Humans; Infant, Newborn; Infectious Disease Transmission, V | 1997 |
Microencephaly and selective decreases in cerebellar Purkinje cell numbers following combined exposure to ethanol and methadone during rat brain development.
Topics: Animals; Body Weight; Cell Count; Cell Division; Central Nervous System Depressants; Cerebellum; Dru | 1997 |
Abnormal umbilical artery flow velocity waveform--a sign of fetal narcotic withdrawal?
Topics: Adult; Blood Flow Velocity; Cesarean Section; Female; Fetal Growth Retardation; Fetal Monitoring; He | 1997 |
Infants born to narcotic dependent mothers: physical growth patterns in the first 12 months of life.
Topics: Adult; Cohort Studies; Female; Fetal Growth Retardation; Growth; Humans; Infant; Infant, Newborn; Me | 1997 |
Neonatal withdrawal following pre- and postnatal exposure to methadone in the rat.
Topics: Animals; Animals, Newborn; Behavior, Animal; Female; Humans; Infant, Newborn; Male; Methadone; Motor | 1998 |
Effectiveness of CME workshops for alcohol and other drug-related interventions in general practice.
Topics: Accreditation; Alcoholism; Australia; Education, Medical, Continuing; Family Practice; Female; Human | 1998 |
Methadone maintenance in pregnancy: a reappraisal.
Topics: Adult; Cocaine; Female; Fetus; Humans; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Com | 1998 |
In contrast to cocaine, prenatal exposure to methadone does not produce detectable alterations in the developing mouse brain.
Topics: Aging; Animals; Animals, Newborn; Astrocytes; Brain; Cerebral Cortex; Cocaine; Cocaine-Related Disor | 1998 |
Opioid detoxification in pregnancy.
Topics: Adult; Analgesics; Analgesics, Opioid; Chi-Square Distribution; Clonidine; Drug Therapy, Combination | 1998 |
Unilateral trigeminal and facial nerve palsies associated with epidural analgesia in labour.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, No | 1998 |
Maternal use of heroin and methadone and infant birth weight.
Topics: Birth Weight; Female; Heroin Dependence; Humans; Methadone; Narcotics; Pregnancy; Pregnancy Complica | 1998 |
Attachment behavior and its antecedents in offspring born to methadone-maintained women.
Topics: Adult; Black or African American; Case-Control Studies; Chi-Square Distribution; Child of Impaired P | 1999 |
[Pregnancy, abortion and delivery in a cohort of heroin dependent patients treated with drug substitution (methadone and buprenorphine) in Aquitaine].
Topics: Abortion, Legal; Adult; Buprenorphine; Cohort Studies; Female; France; Heroin Dependence; Humans; Me | 1999 |
Hyperphagia in neonates withdrawing from methadone.
Topics: Adult; Birth Weight; Body Weight; Female; Humans; Hyperphagia; Incidence; Infant, Newborn; Linear Mo | 1999 |
Translating clinical trial results into practice: the effect of an AIDS clinical trial on prescribed antiretroviral therapy for HIV-infected pregnant women.
Topics: Adult; Analgesics, Opioid; Anti-HIV Agents; Clinical Protocols; Clinical Trials as Topic; Community | 1999 |
Shorter dosing interval of opiate solution shortens hospital stay for methadone babies.
Topics: Drug Administration Schedule; Female; Hospitalization; Humans; Infant, Newborn; Length of Stay; Mate | 1999 |
Outcome predictors in pregnant opiate and polydrug users.
Topics: Benzodiazepines; Birth Weight; Female; Humans; Infant, Low Birth Weight; Infant, Newborn; Methadone; | 1999 |
Alterations in methadone metabolism during late pregnancy.
Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Half-Life; Humans; Me | 1999 |
Use of methadone.
Topics: Analgesics, Opioid; Drug Interactions; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonat | 2000 |
Birth outcome in incarcerated, high-risk pregnant women.
Topics: Adult; Female; Humans; Methadone; Narcotics; Pregnancy; Pregnancy Outcome; Pregnancy, High-Risk; Pre | 2000 |
The drug epidemic: effects on newborn infants and health resource consumption at a tertiary perinatal centre.
Topics: Adult; Ambulatory Care Facilities; Amphetamines; Australia; Benzodiazepines; Cannabis; Cocaine; Como | 2000 |
[Methadone treatment during pregnancy and its effect on the child. Better than continuing drug abuse, should be monitored by a specialized antenatal care center].
Topics: Adult; Embryonic and Fetal Development; Female; Heroin Dependence; Humans; Infant, Newborn; Maternal | 2000 |
[Drug dependence in pregnancy. Better to substitute than complete withdrawal].
Topics: Analgesics, Opioid; Buprenorphine; Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Ne | 2000 |
[The first pregnancy and delivery within the framework of the methadone program in the Czech Republic].
Topics: Adult; Czech Republic; Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Pregnancy; Pre | 2000 |
[Postpartum risk factors in the development of children born to opiate-addicted mothers; comparison between mothers with and without methadone substitution].
Topics: Adult; Birth Weight; Case-Control Studies; Child Advocacy; Child Development; Female; Germany; Gesta | 2000 |
Treatment of opioid dependence in pregnant women.
Topics: Adult; Female; HIV Infections; Humans; Infant, Newborn; Life Style; Methadone; Narcotics; Neonatal A | 2000 |
[Neonatal withdrawal syndrome in twins born to a mother on methadone substitution].
Topics: Adult; Diseases in Twins; Female; Follow-Up Studies; Heroin Dependence; Humans; Infant, Newborn; Met | 2000 |
Mothers and methadone.
Topics: Analgesics, Opioid; Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Neonatal Abstinen | 2000 |
Perinatal opioids reduce striatal nerve growth factor content in rat striatum.
Topics: Animals; Animals, Newborn; Buprenorphine; Corpus Striatum; Female; Male; Methadone; Narcotics; Nerve | 2001 |
[Opiate dependent pregnant patients and mothers. What must be regarded in drug substitution and detoxification].
Topics: Ambulatory Care; Female; Germany; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; | 2001 |
[Evaluation of health status in participants from a methadone treatment program in Krakow after one year of maintenance treatment].
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders; Poland; Pregnancy; Pr | 2001 |
Coordinated outpatient care of the narcotic-dependent infant.
Topics: Ambulatory Care; Child Health Services; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; | 2001 |
Methadone and the pregnant user: a matter for careful clinical consideration.
Topics: Female; Heroin Dependence; Humans; Maternal Health Services; Methadone; Pregnancy; Pregnancy Complic | 2001 |
Smoking during pregnancy and intention to quit: a profile of methadone-maintained women.
Topics: Adult; Attitude to Health; Carbon Monoxide; Cotinine; Ethnicity; Female; Follow-Up Studies; Heroin D | 2001 |
Methadone dependence and its effects on consecutive pregnancies.
Topics: Adolescent; Adult; Birth Weight; Dose-Response Relationship, Drug; Female; Fetal Growth Retardation; | 2000 |
Congenital malformations of the central nervous system produced by narcotic analgesics in the hamster.
Topics: Abnormalities, Drug-Induced; Analgesics, Opioid; Animals; Central Nervous System; Female; Fetal Deat | 1975 |
Pharmacotherapy of narcotic dependence.
Topics: Buprenorphine; Cyclazocine; Dextropropoxyphene; Diphenoxylate; Female; Humans; Infant, Newborn; Infa | 1977 |
Drug addiction in pregnancy.
Topics: Adult; Female; Follow-Up Studies; Heroin; Heroin Dependence; Humans; Infant, Newborn; Infant, Newbor | 1976 |
Late withdrawal symptoms in babies born to methadone addicts.
Topics: Adult; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal | 1977 |
The placental transfer and materno-fetal disposition of methadone in monkeys.
Topics: Animals; Female; Gestational Age; Haplorhini; Macaca mulatta; Maternal-Fetal Exchange; Methadone; Pr | 1978 |
Motor activity and learning ability in rats perinatally exposed to methadone.
Topics: Animals; Female; Learning; Male; Maternal-Fetal Exchange; Methadone; Motor Activity; Pregnancy; Rats | 1979 |
Overview: protracted effects of early exposure to drugs of abuse.
Topics: Animals; Female; Growth; Haplorhini; Heroin Dependence; Humans; Methadone; Opioid-Related Disorders; | 1979 |
Palmar crease variants and their clinical significance: a study of newborns at risk.
Topics: Adult; Age Factors; Child; Child, Preschool; Dermatoglyphics; Down Syndrome; Female; Fetus; Hand; Hu | 1977 |
Mechanism of action of narcotics in the production of menstrual dysfunction in women.
Topics: Adult; Amenorrhea; Barbiturates; Central Nervous System; Corpus Luteum; Ethinyl Estradiol; Female; F | 1975 |
Management of pregnant drug-dependent women.
Topics: Family Therapy; Female; Heroin Dependence; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant | 1978 |
Perinatal addiction: outcome and management.
Topics: Abruptio Placentae; Apgar Score; Breech Presentation; Cesarean Section; Counseling; Female; Fetal Gr | 1977 |
Localization of methadone in fetal rat eye by the immunofluorescence technic.
Topics: Animals; Animals, Newborn; Drug Tolerance; Female; Fetus; Fluorescent Antibody Technique; Methadone; | 1977 |
Methadone detection in rat myenteric plexus: comparison with findings in the central nervous system by the immunofluorescence method.
Topics: Animals; Central Nervous System; Female; Fluorescent Antibody Technique; Ganglia; Male; Maternal-Fet | 1978 |
[The effect of heroin and methadone on pregnancy and the newborn infant].
Topics: Female; Fetus; Heroin; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Labor, | 1979 |
Perinatal drug abuse.
Topics: Amphetamines; Barbiturates; Cannabis; Cocaine; Female; Fetal Alcohol Spectrum Disorders; Heroin Depe | 1979 |
Imparied thermal regulation in juvenile rats following perinatal methadone exposure.
Topics: Animals; Animals, Newborn; Body Temperature Regulation; Body Weight; Feeding Behavior; Female; Male; | 1979 |
Prenatal exposure to methadone HCL in relationship to body and brain growth in the rat.
Topics: Age Factors; Animals; Body Weight; Brain; Cell Count; Cerebral Cortex; Female; Fetus; Male; Maternal | 1979 |
Learning ability in adult female rats perinatally exposed to methadone.
Topics: Animals; Animals, Newborn; Avoidance Learning; Body Weight; Female; Learning; Methadone; Pregnancy; | 1979 |
Cardiac effects of 1-alpha-acetylmethadol (LAAM) in different species.
Topics: Animals; Calcium; Depression, Chemical; Drug Interactions; Female; Guinea Pigs; Heart; Heart Rate; I | 1979 |
The congenitally methadone-addicted infant.
Topics: Child Development; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchan | 1979 |
Outcomes of pregnancy for addicts receiving comprehensive care.
Topics: Adult; Bilirubin; Birth Weight; Comprehensive Health Care; Female; Gestational Age; Humans; Infant, | 1979 |
Methadone exposure in utero: developmental status at one and two years of age.
Topics: Aging; Female; Growth; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Intelligence Test | 1979 |
Children of methadone-treated women at five years of age.
Topics: Behavior; Child, Preschool; Cognition; Female; Heroin Dependence; Humans; Male; Mental Processes; Me | 1979 |
Methadone disposition during the perinatal period in humans.
Topics: Adult; Amniotic Fluid; Animals; Biotransformation; Female; Fetal Blood; Gestational Age; Humans; Inf | 1979 |
Effects of prenatal methadone on the rest-activity cycle of the pre-weanling rat.
Topics: Aging; Animals; Female; Methadone; Motor Activity; Pregnancy; Rats; Sleep; Time Factors | 1979 |
Behavioral effects of fetal and neonatal exposure to methadone in the rat.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Emotions; Female; Fetus; Growth; Male; Methadone; Pre | 1979 |
Sudden unexpected death in infants of narcotic-dependent mothers.
Topics: Adolescent; Adult; Female; Heroin Dependence; Humans; Infant; Infant, Newborn; Male; Maternal-Fetal | 1978 |
Effect of maternal methadone addiction on offspring in rats.
Topics: Animals; Birth Weight; Brain; Brain Chemistry; Female; Humans; Maternal-Fetal Exchange; Methadone; O | 1977 |
Commonly asked clinical questions about methadone maintenance.
Topics: Age Factors; Antidepressive Agents; Community Mental Health Services; Comprehensive Health Care; Fac | 1977 |
Blockade of the preovulatory LH surge by methadone in rats.
Topics: Animals; Depression, Chemical; Female; Luteinizing Hormone; Methadone; Ovulation; Pregnancy; Proestr | 1978 |
Perinatal methadone addiction affects brain synaptic development of biogenic amine systems in the rat.
Topics: Animals; Animals, Newborn; Biogenic Amines; Body Weight; Brain; Female; Humans; Maternal-Fetal Excha | 1979 |
Narcotic abuse in pregnancy.
Topics: Adult; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Pre | 1979 |
Morphine and methadone-induced antinociception in rats permanently depleted of brain dopamine.
Topics: Analgesics; Animals; Brain; Dopamine; Female; Hydroxydopamines; Methadone; Morphine; Norepinephrine; | 1977 |
The narcotic-dependent mother: fetal and neonatal consequences.
Topics: Adult; Female; Fetal Death; Fetus; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn; Inf | 1977 |
Perinatal methadone exposure and brain development: a biochemical study.
Topics: Animals; Body Weight; Brain; Cerebellum; DNA; Female; Lactation; Male; Maternal-Fetal Exchange; Meth | 1978 |
Problems pertaining to the care of newborn infants of drug-addicted women.
Topics: Apnea; Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Narcotics; P | 1978 |
Psychosocial care of the pregnant narcotic addict.
Topics: Behavior Therapy; Female; Heroin Dependence; Humans; Infant, Low Birth Weight; Infant, Newborn; Infa | 1978 |
Chromosome aberrations in the mother and the newborn from drug-addiction pregnancies.
Topics: Blood Cells; Chromatids; Chromosome Aberrations; Female; Heroin Dependence; Humans; Infant, Newborn; | 1978 |
Methadone.
Topics: Female; Humans; Methadone; Pregnancy; Pregnancy Complications; Substance-Related Disorders | 1978 |
A comparative study on the behavioral response of offspring of female rats chronically treated with methadone and morphine.
Topics: Animals; Avoidance Learning; Behavior, Animal; Female; Male; Methadone; Morphine; Motor Activity; Pr | 1978 |
Effects of chronic methadone treatment on maternal body weight and food and water consumption in rats.
Topics: Animals; Body Weight; Drinking; Eating; Female; Injections, Intraperitoneal; Lactation; Methadone; P | 1978 |
Perinatal methadone exposure in rats. Effects on body and organ development.
Topics: Animals; Animals, Newborn; Body Water; Body Weight; Female; Fetus; Growth; Lactation; Maternal-Fetal | 1978 |
Methadone.
Topics: Female; Heroin Dependence; Humans; Methadone; Pregnancy; Pregnancy Complications | 1978 |
Chronic methadone administration to male rats: tolerance to adverse effects on sires and their progeny.
Topics: Animals; Behavior, Animal; Body Weight; Drug Tolerance; Female; Genes, Dominant; Genes, Lethal; Male | 1978 |
Methadone during pregnancy: assessment of behavioral effects in the rat offspring.
Topics: Animals; Behavior, Animal; Birth Weight; Conditioning, Operant; Discrimination, Psychological; Femal | 1979 |
Fetal consequences of chronic methadone administration to pregnant rats: methadological problems.
Topics: Animals; Animals, Newborn; Birth Weight; Female; Fetus; Humans; Maternal-Fetal Exchange; Methadone; | 1975 |
Observation and treatment of neonatal narcotic withdrawal.
Topics: Diazepam; Drug Therapy, Combination; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, New | 1977 |
Experiences with 118 infants born to narcotic-using mothers. Does a lowered serum-ionized calcium level contribute to the symptoms of withdrawal?
Topics: Calcium; Female; Follow-Up Studies; Heroin Dependence; Humans; Infant, Low Birth Weight; Infant, New | 1977 |
Neonatal withdrawal symptoms associated with glutethimide (Doriden) addiction in the mother during pregnancy.
Topics: Female; Glutethimide; Heroin Dependence; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, | 1977 |
The effects of different schedules of methadone treatment on rat brain development.
Topics: Age Factors; Animals; Body Weight; Brain; Cerebellum; Female; Lactation; Male; Methadone; Organ Size | 1977 |
Control of ventilation in pregnant methadone maintenance subjects.
Topics: Carbon Dioxide; Drug Tolerance; Female; Humans; Hyperventilation; Male; Methadone; Pregnancy; Respir | 1977 |
The effect of maternally administered methadone on brain development in the offspring.
Topics: Animals; Avoidance Learning; Brain; DNA; Female; Growth; Male; Maternal-Fetal Exchange; Methadone; N | 1977 |
Maternal ingested methadone, body fluid methadone, and the neonatal withdrawal syndrome.
Topics: Amniotic Fluid; Body Fluids; Female; Fetal Blood; Fetus; Heroin Dependence; Humans; Infant, Newborn; | 1977 |
Effect of chronic maternal methadone exposure on perinatal development.
Topics: Animals; Animals, Newborn; Body Weight; Brain; Cerebellum; Female; Fetus; Male; Maternal-Fetal Excha | 1977 |
Methadone and brain development.
Topics: Animals; Brain; Brain Chemistry; DNA; Female; Gestational Age; Lactation; Maternal-Fetal Exchange; M | 1977 |
Narcotic dependency in pregnancy. Methadone maintenance compared to use of street drugs.
Topics: Adolescent; Adult; Apgar Score; Birth Weight; Child, Preschool; Female; Follow-Up Studies; Heroin De | 1976 |
Amniotic fluid and fetal maturity.
Topics: Amniotic Fluid; Female; Humans; Lung; Methadone; Phosphatidylcholines; Pregnancy; Pulmonary Surfacta | 1976 |
Behavioural concomitants of prenatal addiction to narcotics.
Topics: Child Development; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Feta | 1976 |
Tissue distribution of levo-methadone in nonpregnant and pregnant female and male mice: effect of SKF 525-A 1,2.
Topics: Animals; Dealkylation; Female; Fetus; Male; Methadone; Mice; Organ Specificity; Pregnancy; Proadifen | 1976 |
Effects of neonatal or maternal methadone administration on ornithine decarboxylase activity in brain and heart of developing rats.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Brain; Carboxy-Lyases; Female; Heart; Methadone; Myoc | 1976 |
Effects of methadone hydrochloride on the growth of organotypic cerebellar cultures prepared from methadone-tolerant and control rats.
Topics: Animals; Animals, Newborn; Cells, Cultured; Cerebellum; Drug Tolerance; Female; Male; Maternal-Fetal | 1976 |
Differential effects of maternal heroin and methadone use on birthweight.
Topics: Adult; Birth Weight; Dose-Response Relationship, Drug; Ethnicity; Female; Gestational Age; Heroin; H | 1976 |
Neonatal drug dependence: developmental and bio-cultural considerations.
Topics: Birth Weight; Family Characteristics; Female; Fetus; Humans; Infant Mortality; Infant, Newborn; Infa | 1976 |
Urinary amine alterations in drug-addiction pregnancy.
Topics: Adolescent; Adult; Epinephrine; Female; Heroin; Humans; Methadone; Norepinephrine; Pregnancy; Pregna | 1976 |
Relationship of neonatal withdrawal to maternal methadone dose.
Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Preg | 1976 |
Heroin addiction, methadone maintenance, and pregnancy.
Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Nutritional Physiological Phenomena; | 1976 |
Methadone maintenance: it ain't what it used to be.
Topics: Attitude of Health Personnel; Evaluation Studies as Topic; Female; Fetus; Heroin Dependence; Humans; | 1976 |
Results of 313 consecutive live births of infants delivered to patients in the New York City Methadone Maintenance Treatment Program.
Topics: Adolescent; Adult; Apgar Score; Birth Weight; Drug and Narcotic Control; Female; Fetus; Follow-Up St | 1975 |
Methadone assays in pregnant women and progeny.
Topics: Amniotic Fluid; Chromatography, Gas; Female; Fetus; Heroin Dependence; Humans; Infant, Newborn; Infa | 1975 |
Observations on methadone withdrawal in 16 neonates.
Topics: Adolescent; Adult; Birth Weight; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn | 1975 |
Development of a "blood-brain barrier" to methadone in the newborn rat.
Topics: Animals; Animals, Newborn; Blood-Brain Barrier; Brain; Brain Chemistry; Female; Fetus; Male; Materna | 1975 |
Fetal stress from methadone withdrawal.
Topics: Adrenal Glands; Amniocentesis; Amniotic Fluid; Epinephrine; Female; Fetus; Heroin Dependence; Humans | 1975 |
Guidelines for the management of hospitalized narcotics addicts.
Topics: Analgesia; Drug Administration Schedule; Drug Combinations; Drug Interactions; Female; Heroin; Hospi | 1975 |
Intrapartum gonococcal amnionitis.
Topics: Acute Disease; Adult; Amnion; Apgar Score; Female; Gonorrhea; Heroin Dependence; Humans; Infant, New | 1975 |
Multiple births in drug-addicted women.
Topics: Adult; Female; Heroin; Heroin Dependence; Humans; Infant, Newborn; Male; Methadone; Ovulation; Pregn | 1975 |
Acute management of neonatal addiction.
Topics: Antidiarrheals; Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant | 1975 |
Disposition of methadone and its relationship to severity of withdrawal in the newborn.
Topics: Administration, Oral; Chromatography, Gas; Dose-Response Relationship, Drug; Female; Fetal Blood; Ha | 1975 |
A study of factors that influence the severity of neonatal narcotic withdrawal.
Topics: Administration, Oral; Bilirubin; Birth Weight; Body Weight; Dose-Response Relationship, Drug; Enviro | 1975 |
Current concepts in the management of the pregnant opiate addict.
Topics: Administration, Oral; Anesthesia, Conduction; Anesthesia, Obstetrical; Birth Weight; Counseling; Fem | 1975 |
Neurological aspects of perinatal narcotic addiction and methadone treatment.
Topics: Auditory Perception; Autonomic Nervous System; Birth Weight; Central Nervous System Diseases; Child | 1975 |
Part II. Behavioral and electrophysiological characteristics of the addicted neonate.
Topics: Acoustic Stimulation; Arousal; Attention; Birth Weight; Electrophysiology; Evoked Potentials; Female | 1975 |
Neonatal addiction: a two-year study. Part I. Clinical and developmental characteristics of infants of mothers on methadone maintenance.
Topics: Administration, Oral; Age Factors; Attention; Birth Weight; Child Development; Diazepam; Dose-Respon | 1975 |
Somatic growth effects of perinatal addiction.
Topics: Birth Weight; Cephalometry; Child; Child Development; Child Nutritional Physiological Phenomena; Chi | 1975 |
Differential effects of heroin and methadone on birth weights.
Topics: Birth Weight; Dose-Response Relationship, Drug; Female; Fetus; Gestational Age; Heroin Dependence; H | 1975 |
Cytogenetic risks to the offspring of pregnant addicts.
Topics: Chromosome Aberrations; Female; Fetus; Heroin Dependence; Humans; Infant, Newborn; Karyotyping; Male | 1975 |
Heat-stable alkaline phosphatase in methadone-maintained pregnancies.
Topics: Administration, Oral; Alkaline Phosphatase; Female; Fetal Blood; Gestational Age; Heroin Dependence; | 1975 |
Philadelphia's community based drug abuse program: broader medical and social concepts.
Topics: Alcoholism; Community Mental Health Services; Counseling; Female; Heroin Dependence; Humans; Male; M | 1975 |
Effect of maternal heroin addiction on 67 liveborn neonates. Withdrawal symptoms, small body size, and small head circumference were frequent findings.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Birth Weight; Blood Glucose; Cephalomet | 1975 |
The effects of methadone on maternal-fetal interactions in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Dose-Response Relationship, Drug; Female; Fetal D | 1975 |
Clinical observations on methadone-maintained pregnancies.
Topics: Administration, Oral; Adult; Birth Weight; Counseling; Dose-Response Relationship, Drug; Female; Fet | 1975 |
Narcotic addiction in the newborn: differences in behavior generated by methadone and heroin.
Topics: Adaptation, Physiological; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, New | 1975 |
Comparison of eight kits for the diagnosis of pregnancy.
Topics: Chlorpromazine; Chorionic Gonadotropin; Evaluation Studies as Topic; False Negative Reactions; False | 1975 |
Behavior of narcotics-addicted newborns.
Topics: Adult; Attention; Female; Habituation, Psychophysiologic; Heroin; Humans; Infant, Newborn; Infant, N | 1975 |
Brain concentration of methadone after administration of 14C labelled dl-methadone to pregnant rats by different routes.
Topics: Administration, Oral; Animals; Brain; Duodenum; Female; Fetus; Injections; Injections, Intraperitone | 1975 |
Neonatal narcotic abstinence: Effects of pharmacotherapeutic agents and maternal drug usage on nutritive sucking behavior.
Topics: Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Opium; Phenob | 1976 |
A study of factors that influence the severity of neonatal narcotic withdrawal.
Topics: Apgar Score; Female; Gestational Age; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lighting; | 1976 |
Cytogenetics of methadone-managed and heroin-addicted pregnant women and their newborn infants.
Topics: Adolescent; Adult; Apgar Score; Chromosome Aberrations; Female; Fetal Blood; Heroin Dependence; Huma | 1976 |
The effect of methadone on fetal brain function.
Topics: Animals; Brain; Carotid Arteries; Female; Fetal Heart; Fetus; Heart Rate; Methadone; Pregnancy; Regi | 1976 |
Methadone during pregnancy in the rat: dose level effects on maternal and perinatal mortality and growth in the offspring.
Topics: Abnormalities, Drug-Induced; Animals; Birth Weight; Body Weight; Female; Fetal Death; Fetus; Gestati | 1976 |
Sub-lethal effects on offspring of male rats treated with methadone before mating.
Topics: Animals; Birth Weight; Body Weight; Female; Fertility; Growth; Male; Methadone; Pregnancy; Rats; Sex | 1976 |
Drug addiction in pregnancy and the neonate.
Topics: Alcoholic Intoxication; Birth Weight; Diazepam; Female; Heroin Dependence; Hospitalization; Humans; | 1976 |
Pharmacologic observations on the neonatal withdrawal syndrome.
Topics: Female; Half-Life; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Kinetics; | 1976 |
Establishment of a liaison service for pregnant opiate-dependent women.
Topics: Adolescent; Adult; Behavior, Addictive; England; Female; Health Promotion; HIV Infections; Humans; I | 1992 |
Narcotic addiction in pregnancy with adverse maternal and perinatal outcome.
Topics: Adult; Female; Fetal Growth Retardation; Heroin Dependence; Hong Kong; Humans; Infant, Low Birth Wei | 1992 |
Improving treatment outcome in pregnant opiate-dependent women.
Topics: Adult; Combined Modality Therapy; Female; Fetal Growth Retardation; Follow-Up Studies; Heroin; Heroi | 1992 |
[Drug dependence, smoking and fetal growth retardation].
Topics: Acid-Base Equilibrium; Adult; Birth Weight; Drug Synergism; Female; Fetal Growth Retardation; Gestat | 1992 |
[Heroin abuse and methadone substitution in pregnancy].
Topics: Asphyxia Neonatorum; Cardiotocography; Dose-Response Relationship, Drug; Female; Fetal Growth Retard | 1992 |
[Drug substitution and withdrawal in pregnancy. Indication, side effects, acute status, monitoring and results].
Topics: Contraindications; Counseling; Drug Overdose; Female; Heroin Dependence; Humans; Infant, Newborn; Me | 1991 |
[Jurisprudence aspects of drug substitution and withdrawal in pregnancy].
Topics: Female; Germany; Humans; Infant, Newborn; Jurisprudence; Methadone; Neonatal Abstinence Syndrome; Pr | 1991 |
Prenatal exposure to methadone affects central cholinergic neuronal activity in the weanling rat.
Topics: Acetylcholine; Animals; Brain; Dopamine; Female; Methadone; Neurons; Norepinephrine; Parasympathetic | 1991 |
The effect of chronic oral methadone treatment on monkey chorionic gonadotropin, estradiol, dehydroepiandrosterone sulfate, progesterone, prolactin and cortisol levels during pregnancy in the cynomolgus monkey (Macaca fascicularis).
Topics: Animals; Birth Weight; Chorionic Gonadotropin; Dehydroepiandrosterone; Estradiol; Female; Fetal Grow | 1991 |
The effect of prenatal methadone exposure of development and nociception during the early postnatal period of the rat.
Topics: Animals; Female; Methadone; Morphine; Nociceptors; Pregnancy; Prenatal Exposure Delayed Effects; Rat | 1990 |
Methadone levels and neonatal withdrawal.
Topics: Adult; Dose-Response Relationship, Drug; Female; Fetal Blood; Humans; Infant, Newborn; Male; Methado | 1991 |
A comparison of the effects of single- and split-dose methadone administration on the fetus: ultrasound evaluation.
Topics: Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fetal Movement; Humans; Infa | 1991 |
The effect of prenatal exposure to methadone on neurotransmitters in neonatal rats.
Topics: Acetylcholine; Animals; Animals, Newborn; Brain Chemistry; Corpus Striatum; Dopamine; Female; Male; | 1990 |
Narcotic addiction: the expectant mother and her baby.
Topics: Adolescent; Adult; Diseases in Twins; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Pr | 1990 |
[Prenatal development and postnatal morbidity of newborn infants of HIV positive mothers].
Topics: Birth Weight; Female; Fetal Growth Retardation; Gestational Age; HIV Seropositivity; Humans; Infant, | 1990 |
Report of the Expert Advisory Committee on the Use of Drugs in the Treatment of Abuse and Dependence to Narcotic and Controlled Drugs.
Topics: Canada; Drug and Narcotic Control; Female; Humans; Inactivation, Metabolic; Methadone; Opioid-Relate | 1990 |
Diazepam abuse in pregnant women on methadone maintenance. Implications for the neonate.
Topics: Adult; Diazepam; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Infant, Newborn, Diseas | 1990 |
Patterns of multiple substance abuse during pregnancy: implications for mother and fetus.
Topics: Adolescent; Adult; Age Factors; Alcoholism; Cocaine; Female; Fetal Diseases; Heroin; Humans; Marijua | 1990 |
Infrequent neonatal opiate withdrawal following maternal methadone detoxification during pregnancy.
Topics: Adult; Birth Weight; Embryonic and Fetal Development; Female; Humans; Infant, Newborn; Maternal-Feta | 1990 |
Effects of prenatal methadone exposure on sex-dimorphic behavior in early school-age children.
Topics: Child; Female; Gender Identity; Humans; Male; Methadone; Pregnancy; Prenatal Exposure Delayed Effect | 1990 |
Drug-addicted mothers, their infants, and SIDS.
Topics: Adult; Alcohol Drinking; Cocaine; Developmental Disabilities; Female; Heroin Dependence; Humans; Inf | 1988 |
Neonatal behavior after drug dependent pregnancy.
Topics: Child; Child Behavior; Child, Preschool; Developmental Disabilities; Electroencephalography; Female; | 1989 |
Altered methadone pharmacokinetics in pregnancy: implications for dosing.
Topics: Adult; Computer Simulation; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; | 1989 |
Kinin-kininase system in drug addict woman in pregnancy and puerperium.
Topics: Carboxypeptidases; Female; Humans; Kallikreins; Lysine Carboxypeptidase; Methadone; Peptidyl-Dipepti | 1989 |
Kallikrein-kinin system in newborns of the drug addicted.
Topics: Aging; Carboxypeptidases; Female; Humans; Infant, Newborn; Kallikreins; Lysine Carboxypeptidase; Mal | 1989 |
Outpatient methadone programme for pregnant heroin using women.
Topics: Adult; Ambulatory Care; Evaluation Studies as Topic; Female; Heroin Dependence; Humans; Methadone; N | 1989 |
[Proposal of a detoxication program for drug dependency in pregnancy].
Topics: Female; Humans; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Complications | 1989 |
Prenatal cocaine exposure is associated with respiratory pattern abnormalities.
Topics: Apnea; Cheyne-Stokes Respiration; Cocaine; Female; Humans; Infant, Newborn; Methadone; Pregnancy; Pr | 1989 |
NIDA's Medication Development Program--1989.
Topics: Acquired Immunodeficiency Syndrome; Brain; Cocaine; Drug and Narcotic Control; Female; Heroin Depend | 1989 |
Perinatal cocaine intoxication.
Topics: Adult; Cocaine; Female; Follow-Up Studies; Humans; Infant, Newborn; Male; Methadone; Neonatal Abstin | 1989 |
Clinical studies of infants and children exposed prenatally to heroin.
Topics: Child Behavior; Child Development; Child, Preschool; Cognition; Female; Heroin Dependence; Humans; I | 1989 |
Developmental consequences of prenatal exposure to methadone.
Topics: Child Development; Child, Preschool; Female; Growth; Humans; Infant; Infant, Newborn; Intelligence; | 1989 |
The effects of methadone treatment on the reactivity of the nonstress test.
Topics: Female; Fetal Movement; Heart Rate, Fetal; Humans; Methadone; Opioid-Related Disorders; Pregnancy; P | 1989 |
Low prevalence of human immunodeficiency virus infection in methadone program attenders and pregnant intravenous drug users in the western metropolitan region of Sydney.
Topics: Adult; Australia; Cross-Sectional Studies; Female; HIV Antibodies; HIV Seropositivity; Humans; Male; | 1989 |
Methadone maintenance in pregnancy: consequences to care and outcome.
Topics: Female; Humans; Methadone; Pregnancy; Pregnancy Complications; Substance-Related Disorders | 1989 |
Prospective study of human immunodeficiency virus infection and pregnancy outcomes in intravenous drug users.
Topics: Adult; Female; HIV Seropositivity; Hospitalization; Humans; Injections, Intravenous; Methadone; New | 1989 |
Behaviour in first year after drug dependent pregnancy.
Topics: Child Behavior; Child Development; Electroencephalography; Female; Humans; Illicit Drugs; Infant; In | 1989 |
Reduced estriol and dehydroepiandrosterone sulphate plasma levels in methadone-addicted pregnant women.
Topics: Adult; Circadian Rhythm; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estriol; Female; Ge | 1986 |
The interference of naloxone hydrochloride in the teratogenic activity of opiates.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Central Nervous System; D-Ala(2),MePh | 1985 |
Opioid receptors in human placenta may be affected by methadone and propoxyphene treatment.
Topics: Cyclazocine; Dextropropoxyphene; Ethylketocyclazocine; Female; Humans; In Vitro Techniques; Methadon | 1985 |
Maternal-fetal transfer of abused substances: pharmacokinetic and pharmacodynamic data.
Topics: Amphetamine; Animals; Cocaine; Dronabinol; Female; Fetus; Humans; Kinetics; Lysergic Acid Diethylami | 1985 |
Effects of cocaine on pregnancy outcome.
Topics: Abortion, Spontaneous; Adult; Birth Weight; Body Height; Female; Humans; Infant, Newborn; Maternal-F | 1986 |
Perinatal and developmental outcome of infants exposed to methadone in-utero.
Topics: Birth Weight; Female; Humans; Infant, Newborn; Methadone; Pregnancy | 1987 |
Cocaine- and methadone-exposed infants: a comparison.
Topics: Cocaine; Embryonic and Fetal Development; Female; Humans; Infant, Newborn; Methadone; Obstetric Labo | 1987 |
Inhaling heroin during pregnancy.
Topics: Female; Heroin Dependence; Humans; Methadone; Pregnancy; Pregnancy Complications | 1988 |
Inhaling heroin during pregnancy.
Topics: Female; Heroin; Heroin Dependence; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; | 1988 |
The use of tricyclic antidepressants in methadone maintained pregnant women and infant outcome.
Topics: Adult; Antidepressive Agents, Tricyclic; Apgar Score; Birth Weight; Demography; Female; Heroin Depen | 1988 |
Methadone maintenance has a tragic price.
Topics: Adolescent; Child; Child Behavior Disorders; Female; Humans; Infant, Newborn; Methadone; Neonatal Ab | 1988 |
Effects of exposure in utero to methadone and buprenorphine on enkephalin levels in the developing rat brain.
Topics: Animals; Brain; Buprenorphine; Dose-Response Relationship, Drug; Enkephalins; Female; Methadone; Pre | 1988 |
[Effects of maternal methadone addiction on the growth and health of the fetus].
Topics: Embryonic and Fetal Development; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Methadone | 1988 |
A review of the characteristics and treatment progress of 45 pregnant opiate addicts attending the Irish National Drug Advisory and Treatment Centre over a two year period.
Topics: Adolescent; Adult; Female; Humans; Infant, Newborn; Ireland; Methadone; Narcotics; Pregnancy; Pregna | 1988 |
Group psychotherapy with methadone-maintained pregnant women.
Topics: Adult; Attitude of Health Personnel; Female; Humans; Methadone; Opioid-Related Disorders; Patient Ed | 1988 |
The effect of chronic methadone treatment on intra-uterine growth of the cynomolgus monkey (Macaca fascicularis).
Topics: Animals; Birth Weight; Embryonic and Fetal Development; Female; Macaca fascicularis; Methadone; Preg | 1988 |
Methadone maintenance in pregnancy: consequences to care and outcome.
Topics: Adult; Alcohol Drinking; Drug Evaluation, Preclinical; Female; Hematocrit; Humans; Methadone; Pregna | 1988 |
Maternal narcotic abuse and the newborn.
Topics: Adolescent; Adult; Female; Heroin; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinenc | 1988 |
An extended physiological pharmacokinetic model of methadone disposition in the rat: validation and sensitivity analysis.
Topics: Animals; Female; Methadone; Models, Biological; Pregnancy; Rats | 1988 |
Maternal drug therapy: effect on fetal and neonatal growth and neurobehavior.
Topics: Aminopterin; Amphetamines; Animals; Anticoagulants; Anticonvulsants; Antihypertensive Agents; Birth | 1986 |
Pregnancy in a drug-abusing population.
Topics: Adult; Female; Gestational Age; Humans; Infant, Newborn; Methadone; Pregnancy; Pregnancy Complicatio | 1986 |
Heroin addiction in pregnancy.
Topics: Female; Heroin Dependence; Humans; Methadone; Midwifery; Pregnancy; Pregnancy Complications | 1986 |
Management of narcotic dependent pregnancy.
Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Narcotics; Opioid-Related Disorders; | 1986 |
Perinatal cocaine and methamphetamine exposure: maternal and neonatal correlates.
Topics: Apgar Score; Birth Weight; Child Behavior; Cocaine; Female; Fetal Growth Retardation; Gestational Ag | 1987 |
Impact of maternal drug dependency on birth weight and head circumference of offspring.
Topics: Adult; Birth Weight; Female; Fetal Growth Retardation; Fetus; Head; Humans; Infant, Newborn; Methado | 1987 |
Maternal narcotic addiction: pregnancy outcome in patients managed by a specialized drug-dependency antenatal clinic.
Topics: Adolescent; Adult; Female; Fetal Death; Health Facilities; Heroin Dependence; Humans; Infant, Newbor | 1987 |
Effect of maternal methadone administration on the development of multiple forms of monoamine oxidase in rat brain and liver.
Topics: Animals; Brain; Female; Isoenzymes; Liver; Methadone; Monoamine Oxidase; Opioid-Related Disorders; P | 1986 |
Methadone in pregnancy: clinical-toxicological aspects.
Topics: Female; Humans; Infant, Newborn; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Complicat | 1986 |
Abnormal sleeping ventilatory pattern in infants of substance-abusing mothers.
Topics: Age Factors; Cocaine; Female; Heart Rate; Heroin; Humans; Infant; Male; Methadone; Narcotics; Phency | 1986 |
Mother-infant interaction in multiproblem families: finding those at risk.
Topics: Adult; Child Development; Female; Humans; Infant; Methadone; Mother-Child Relations; Opioid-Related | 1986 |
Fetal addiction to methadone: postnatal abstinence syndrome and development of visual evoked potentials.
Topics: Animals; Electroencephalography; Evoked Potentials, Visual; Female; Maternal-Fetal Exchange; Methado | 1986 |
A comparative study of the reproductive effects of methadone and benzo[a]pyrene in the pregnant and pseudopregnant rat.
Topics: Animals; Benzo(a)pyrene; Female; Fetal Death; Fetal Resorption; Litter Size; Methadone; Nucleotides, | 1986 |
[Substance dependence and pregnancy. Experience in care].
Topics: Adult; Female; Fetal Growth Retardation; Heroin; Heroin Dependence; Humans; Methadone; Pregnancy; Pr | 1986 |
Occurrence of strabismus in infants born to drug-dependent women.
Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Male; Methadone; Pregnancy; Pregnancy Complicati | 1987 |
Prenatal opioid exposure and the problem of causal inference.
Topics: Animals; Child Development; Dose-Response Relationship, Drug; Female; Fetus; Humans; Kinetics; Metha | 1985 |
Long-term effects of prenatal methadone maintenance.
Topics: Adult; Age Factors; Child; Child Behavior; Child Development; Child, Preschool; Female; Fetus; Follo | 1985 |
Factors affecting head growth and intellectual function in children of drug addicts.
Topics: Age Factors; Cephalometry; Child Development; Cognition; Female; Follow-Up Studies; Head; Heroin Dep | 1985 |
Altered methadone pharmacokinetics in methadone-maintained pregnant women.
Topics: Adult; Female; Humans; Metabolic Clearance Rate; Methadone; Milk, Human; Pregnancy; Pregnancy Compli | 1985 |
Perinatal exposure to methadone and the development of hepatic microsomal testosterone hydroxylation and methadone N-demethylation in the rat.
Topics: Animals; Animals, Newborn; Dealkylation; Female; Fetus; Hydroxylation; Male; Methadone; Microsomes, | 1985 |
Cocaine use in pregnancy.
Topics: Abortion, Spontaneous; Adult; Cocaine; Female; Fetus; Humans; Infant, Newborn; Methadone; Obstetric | 1985 |
Opiate self-administration in adult offspring of methadone-treated female rats.
Topics: Animals; Body Weight; Drinking; Female; Methadone; Morphine; Narcotics; Pregnancy; Prenatal Exposure | 1985 |
Methadone-maintained mothers: 3-year follow-up of parental functioning.
Topics: Child Development; Child Rearing; Female; Follow-Up Studies; Heroin Dependence; Humans; Infant; Infa | 1985 |
When the client is pregnant: information for counselors.
Topics: Adult; Attitude of Health Personnel; Breast Feeding; Family Planning Services; Female; Guilt; Heroin | 1985 |
[Withdrawal symptoms and behavioral disorders in children of mothers taking heroin/methadone during pregnancy].
Topics: Adult; Child Behavior Disorders; Child Development; Child, Preschool; Female; Follow-Up Studies; Her | 1985 |
Offspring born to methadone-maintained women.
Topics: Female; Humans; Infant; Infant, Newborn; Longitudinal Studies; Maternal-Fetal Exchange; Methadone; P | 1985 |
Urinary function during epidural analgesia with methadone and morphine in post-cesarean section patients.
Topics: Adult; Anesthesia, Epidural; Cesarean Section; Female; Humans; Methadone; Morphine; Pain, Postoperat | 1985 |
Analysis of methadone disposition in the pregnant rat by means of a physiological flow model.
Topics: Animals; Female; Gas Chromatography-Mass Spectrometry; Infusions, Parenteral; Injections, Intravenou | 1985 |
Rapid phospholipid test for fetal pulmonary maturity.
Topics: Amniotic Fluid; Chromatography, Paper; Densitometry; Female; Humans; Infant, Newborn; Methadone; Pho | 1974 |
The effect of acute and chronic methadone treatment on the in vitro N-demethylation of methadone by microsomal enzymes of male and pregnant and nonpregnant female rats.
Topics: Animals; Dealkylation; Female; Fetus; Glucosephosphates; In Vitro Techniques; Kinetics; Magnesium; M | 1973 |
[Discussion on methadone programs in the Federal Republic of Germany].
Topics: Ambulatory Care; Female; Germany, West; Heroin Dependence; Hospitalization; Humans; Long-Term Care; | 1973 |
Letter: Pentazocine and neonatal withdrawal symptoms.
Topics: Female; Glutethimide; Humans; Infant, Newborn; Infant, Newborn, Diseases; Long-Term Care; Maternal-F | 1974 |
Estriol excretion profiles in narcotic-addicted pregnant women.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Age Fact | 1972 |
Infant of the addicted mother.
Topics: Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Disea | 1973 |
The effect of a methadone treatment program upon pregnant heroin addicts and their newborn infants.
Topics: Adult; Birth Weight; Blood Glucose; Calcium; Female; Fetus; Gestational Age; Heroin Dependence; Huma | 1974 |
Methadone maintenance during pregnancy: pregnancy, birth, and neonate characteristics.
Topics: Adolescent; Adult; Apgar Score; Birth Weight; Female; Gestational Age; Heroin Dependence; Humans; In | 1974 |
Postpartum weight alteration in hamster offspring from females injected during pregnancy with either heroin, methadone, a composite drug mixture, or mescaline.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Cricetinae; Drug Combinations; Female; Her | 1974 |
Methadone: the mechanism of its success.
Topics: Disease Outbreaks; Drug and Narcotic Control; Female; Heroin Dependence; Humans; Methadone; Pregnanc | 1974 |
[Previous opiate addictions: trial of substitutive therapy using methadone chlorhydrate].
Topics: Administration, Oral; Adult; Ambulatory Care; Codeine; Female; Heroin Dependence; Hospitalization; H | 1974 |
Methadone treatment of heroin dependence.
Topics: Female; Heroin Dependence; Humans; Methadone; Pregnancy | 1974 |
Clinical uses of the Brazelton Neonatal Scale.
Topics: Child Behavior; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Metha | 1974 |
Treatment of heroin addiction. Multimodality approach.
Topics: Counseling; Cyclazocine; Day Care, Medical; Female; Heroin; Heroin Dependence; Humans; Male; Methado | 1973 |
Pregnancies of methadone patients. Findings in New York City Methadone Maintenance Treatment Program.
Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; | 1974 |
Teratogenic activity of methadone hydrochloride in mouse and chick embryos.
Topics: Abnormalities, Drug-Induced; Anencephaly; Animals; Brain; Chick Embryo; Embryo, Mammalian; Female; G | 1973 |
Analyses of methadone and other drugs in maternal and neonatal body fluids: use in evaluation of symptoms in a neonate of mother maintained on methadone.
Topics: Adult; Amniotic Fluid; Body Fluids; Escherichia coli Infections; Female; Fetal Blood; Heroin Depende | 1974 |
Evaluation of a latex tube agglutination-inhibition pregnancy test. An analysis of 1,776 specimens.
Topics: Adult; Agglutination Tests; Antibodies; Chorionic Gonadotropin; Chromatography, Thin Layer; Evaluati | 1973 |
Effect of methadone on human pregnancy tests.
Topics: Chromatography, Thin Layer; False Positive Reactions; Female; Humans; Male; Methadone; Pregnancy; Pr | 1973 |
Guidelines for the withdrawal of narcotic and general depressant drugs.
Topics: Barbiturates; Dose-Response Relationship, Drug; Drug Tolerance; Female; Heroin; Humans; Hypnotics an | 1973 |
Effect of heroin on corticosteroid production in pregnant addicts and their fetuses.
Topics: Adrenal Cortex Hormones; Birth Weight; Blood; Delivery, Obstetric; Female; Fetus; Gestational Age; H | 1973 |
The quantitation of methadone in human amniotic fluid.
Topics: Adult; Amniocentesis; Amniotic Fluid; Chromatography, Gas; Female; Humans; Maternal-Fetal Exchange; | 1973 |
Methadone maintenance, pregnancy, and progeny.
Topics: Administration, Oral; Adult; Apgar Score; Birth Weight; Female; Fetal Death; Heroin; Heroin Dependen | 1973 |
[Psychiatric emergencies during pregnancy and in the puerperium].
Topics: Amphetamine; Cannabis; Emergencies; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lyse | 1973 |
Neonatal narcotic addiction. Comparative effects of maternal intake of heroin and methadone.
Topics: Adult; Apgar Score; Birth Weight; Chlorpromazine; Female; Gestational Age; Heroin Dependence; Humans | 1973 |
Massachusetts Department of Public Health. Massachusetts methadone maintenance programs.
Topics: Adolescent; Boston; Drug and Narcotic Control; Female; Heroin Dependence; Humans; Massachusetts; Met | 1973 |
A model for drug abuse treatment program evaluation.
Topics: Adult; Black or African American; Community Health Services; Counseling; Educational Status; Evaluat | 1973 |
Methadone maintenance during pregnancy.
Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Pregnancy; | 1973 |
The New York City Methadone Maintenance Treatment Program after two years - an overview.
Topics: Adolescent; Community Health Services; Crime; Female; Hepatitis B; Heroin Dependence; Humans; Methad | 1973 |
Special treatment problems in a drug abuse program.
Topics: Adolescent; Alcoholism; Animals; Escape Reaction; Female; Heroin Dependence; Humans; Illinois; Inter | 1973 |
Results of 120 deliveries of patients in the New York City methadone maintenance treatment program.
Topics: Adolescent; Adult; Birth Weight; Delivery, Obstetric; Demography; Ethnicity; Female; Heroin Dependen | 1973 |
Observations on the sudden death of infants born to addicted mothers.
Topics: Adult; Death, Sudden; Female; Heroin Dependence; Humans; Infant; Infant Mortality; Infant, Newborn; | 1973 |
The effect of a methadone treatment program upon pregnant addicts and their infants.
Topics: Adult; Apgar Score; Female; Hepatitis; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn; | 1973 |
Clinical evaluation of pregnant methadone maintenance patients and their newborn infants.
Topics: Adolescent; Adult; Community Health Services; Evaluation Studies as Topic; Female; Heroin Dependence | 1973 |
Treatment experiences with the pregnant addict.
Topics: Adolescent; Adult; Amniotic Fluid; Female; Gestational Age; Hepatitis; Heroin Dependence; Humans; In | 1973 |
Neonatal effects of heroin addiction and methadone-treated pregnancies. Preliminary report on 70 live births.
Topics: Adult; Birth Weight; Dose-Response Relationship, Drug; Female; Heroin Dependence; Humans; Infant, Ne | 1973 |
Pregnancy in the context of narcotic addiction and methadone maintenance.
Topics: Adult; Alcoholism; Barbiturates; Chicago; Female; Heroin Dependence; Humans; Infant Mortality; Infan | 1973 |
L0w dose methadone to abstinence in a maternity-family care program.
Topics: Adult; Family Therapy; Female; Heroin Dependence; Humans; Male; Methadone; Pregnancy; Pregnancy Comp | 1973 |
A preliminary (8-month) report on a low-dose methadone-to-abstinence family care program at Kings County Addicitve Disease Hospital.
Topics: Adolescent; Adult; Community Health Services; Counseling; Female; Heroin Dependence; Humans; Male; M | 1973 |
Methadone effects on pregnancy and the newborn.
Topics: Adolescent; Adult; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Ma | 1973 |
Late presentation of drug withdrawal symptoms in newborns.
Topics: Birth Weight; Camphor; Diazepam; Female; Gestational Age; Heroin Dependence; Humans; Infant; Infant, | 1974 |
Content of amniotic fluid prostaglandins in normal, diabetic, and drug-abuse human pregnancy.
Topics: Amniotic Fluid; Female; Heroin Dependence; Humans; Labor, Obstetric; Methadone; Pregnancy; Pregnancy | 1974 |
Narcotic withdrawal in the newborn infant.
Topics: Diazepam; Female; Fetus; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Mate | 1974 |
Evaluation of a latex agglutination-inhibition slide pregnancy test (Pregnosis).
Topics: Abortion, Spontaneous; Adolescent; Adult; Antidepressive Agents; Chorionic Gonadotropin; Codeine; Co | 1974 |
Effect of chronic methadone adminstration on pregnant rats and their offspring.
Topics: Animals; Animals, Newborn; Body Weight; Embryonic and Fetal Development; Female; Fertility; Fetal De | 1974 |
Born with a habit. Infants of drug-addicted mothers.
Topics: Abnormalities, Drug-Induced; Adult; Age Factors; Barbiturates; Camphor; Chlorpromazine; Codeine; Dia | 1974 |
Perinatal tips.
Topics: Chlorpromazine; Education, Medical, Continuing; Female; Humans; Infant, Newborn; Infant, Newborn, Di | 1974 |
Letter: Evaluation of five commercial pregnancy test kits using urine samples containing methadone.
Topics: Chromatography, Thin Layer; False Positive Reactions; Female; Humans; Male; Methadone; Pregnancy; Pr | 1974 |
Studies of human amniotic fluid phospholipids in normal, diabetic, and drug-abuse pregnancy.
Topics: Amniotic Fluid; Chromatography, Gas; Chromatography, Thin Layer; Densitometry; Fatty Acids; Female; | 1974 |
Teratogenicity studies of methadone HCl in rats and rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Female; Hydrocephalus; Maternal-Fetal Exchange; Methadone; Pre | 1971 |
Heroin addiction during pregnancy.
Topics: Adolescent; Adult; Amniocentesis; Bilirubin; Birth Weight; Female; Gestational Age; Heroin; Humans; | 1972 |
The distribution of methadone in the nonpregnant, pregnant and fetal rat after acute methadone treatment.
Topics: Animals; Brain Chemistry; Carbon Isotopes; Female; Fetus; Gestational Age; Injections, Intraperitone | 1972 |
"Cold turkey" in the newborn.
Topics: Adult; Australia; Diagnosis, Differential; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; | 1972 |
Methadone withdrawal in newborn infants.
Topics: Female; Gestational Age; Heroin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Maternal- | 1972 |
Treatment of a pregnant opiate addict with oral methadone.
Topics: Administration, Oral; Adult; Female; Heroin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Met | 1972 |
Treatment of morphine-type dependence by withdrawal methods.
Topics: Barbiturates; Female; Heroin; Hospitalization; Humans; Male; Meperidine; Methadone; Morphine; Pregna | 1972 |
Oral methadone maintenance techniques in the management of morphine-type dependence.
Topics: Female; Heroin; Hospitalization; Humans; Male; Methadone; Morphine; Pregnancy; Substance-Related Dis | 1972 |
Sudden deaths in infants born to methadone-maintained addicts.
Topics: Adult; Apgar Score; Birth Weight; Death, Sudden; Female; Humans; Infant; Infant Mortality; Maternal- | 1972 |
Treatment of morphine-type dependence.
Topics: Female; Gestational Age; Heroin; Humans; Male; Methadone; Morphine Dependence; Pregnancy; Substance | 1972 |
Drug addiction in pregnancy. An obstetrician's experience.
Topics: Abortion, Induced; Abortion, Spontaneous; Amenorrhea; Anesthesia, Obstetrical; Female; Humans; Infan | 1972 |
Narcotic withdrawal in the newborn.
Topics: Birth Weight; Chlorpromazine; Cocaine; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, N | 1972 |
Neonatal addiction to methadone.
Topics: Female; Heroin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Methado | 1971 |
Effects of methadone on the action of catecholamines in isolated preparations.
Topics: Acetylcholine; Animals; Barium; Cats; Cocaine; Drug Antagonism; Drug Synergism; Epinephrine; Female; | 1971 |
Observations on heroin and methadone withdrawal in the newborn.
Topics: Adolescent; Adult; Apgar Score; Birth Weight; Female; Heroin; Humans; Infant, Newborn; Infant, Newbo | 1971 |
Fertility of narcotics addicts and effects of addiction on the offspring.
Topics: Female; Fertility; Heroin; Humans; Infant, Newborn; Maternal-Fetal Exchange; Methadone; Morphine Dep | 1971 |
Neonatal biliary tract infection coincident with maternal methadone therapy.
Topics: Adult; Cholangitis; Cholecystitis; Female; Heroin; Humans; Infant, Newborn; Infant, Newborn, Disease | 1971 |
Narcotics and medical practice. Medical use of morphine and morphine-like drugs and management of persons dependent on them.
Topics: American Medical Association; Female; Health Education; Heroin; Humans; Legislation, Drug; Methadone | 1971 |
Pregnancy in narcotics addicts treated by medical withdrawal. The methadone detoxification program.
Topics: Adolescent; Adult; Birth Weight; Female; Heroin; Humans; Infant, Newborn; Labor Presentation; Methad | 1969 |
Pregnancy and menstrual function in narcotics addicts treated with methadone. The Methadone Maintenance Treatment Program.
Topics: Adult; Female; Heroin; Humans; Infertility, Female; Menstruation; Methadone; Ovulation; Pregnancy; S | 1969 |
Methadone and children.
Topics: Adolescent; Adult; Child, Preschool; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Mat | 1971 |
Menstrual function and pregnancy in narcotics addicts treated with methadone.
Topics: Abortion, Spontaneous; Adult; Amenorrhea; Female; Fetal Death; Humans; Infant, Newborn; Menstruation | 1968 |