Page last updated: 2024-10-30

methadone and Pregnancy

methadone has been researched along with Pregnancy in 1026 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"Methadone use for the management of opioid dependency during pregnancy is commonplace."9.41Precision dosing of methadone during pregnancy: A pharmacokinetics virtual clinical trials study. ( Badhan, RKS; Gittins, R, 2021)
" While methadone-maintenance currently is the standard of care for opioid dependence during pregnancy, research suggests that buprenorphine-maintenance may be associated with shorter infant hospital lengths of stay (LOS) relative to methadone-maintenance."9.19Design considerations for point-of-care clinical trials comparing methadone and buprenorphine treatment for opioid dependence in pregnancy and for neonatal abstinence syndrome. ( Hall, ES; Lewis, D; Marcotte, M; Theobald, J; Van Hook, J; Wexelblatt, SL; Wilder, C; Winhusen, T, 2014)
"To compare the profile of signs of neonatal abstinence syndrome (NAS) in methadone- versus buprenorphine-exposed infants."9.16Differences in the profile of neonatal abstinence syndrome signs in methadone- versus buprenorphine-exposed neonates. ( Arria, AM; Badger, GJ; Coyle, MG; Gaalema, DE; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; Scott, TL; Stine, SM, 2012)
"Methadone, a full mu-opioid agonist, is the recommended treatment for opioid dependence during pregnancy."9.14Neonatal abstinence syndrome after methadone or buprenorphine exposure. ( Arria, AM; Coyle, MG; Fischer, G; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; O'Grady, KE; Selby, P; Stine, SM, 2010)
" Infants born to buprenorphine maintained women are not exposed to a greater proportion of the maternal dose compared with methadone and may be exposed to relatively less of the maternal dose compared with infants born to women maintained on methadone during pregnancy."9.14(R)- and (S)-methadone and buprenorphine concentration ratios in maternal and umbilical cord plasma following chronic maintenance dosing in pregnancy. ( Foster, DJ; Gordon, AL; Lopatko, OV; Somogyi, AA; White, JM, 2010)
"The aim of the study was to evaluate the effect of substitution therapy in heroin addicted pregnant women on the course of pregnancy, perinatal outcomes and course of the neonatal abstinence syndrome."9.13Prospective randomised comparative study of the effect of buprenorphine, methadone and heroin on the course of pregnancy, birthweight of newborns, early postpartum adaptation and course of the neonatal abstinence syndrome (NAS) in women followed up in the ( Binder, T; Vavrinková, B, 2008)
"Though methadone pharmacotherapy is the treatment of choice for opiate-dependence during pregnancy in the USA, most methadone-exposed neonates develop neonatal abstinence syndrome (NAS)."9.12Maternal vagal tone change in response to methadone is associated with neonatal abstinence syndrome severity in exposed neonates. ( Dipietro, JA; Elko, A; Jansson, LM; Velez, M, 2007)
"Treating opioid-addicted women with methadone in pregnancy increased the number of newborns suffering from neonatal abstinence syndrome (NAS)."9.11Therapy of the neonatal abstinence syndrome with tincture of opium or morphine drops. ( Birkenfeld, L; Hellmich, M; Herkenrath, P; Langenfeld, S; Müller, C; Theisohn, M, 2005)
"This study was designed to compare the neonatal abstinence syndrome (NAS) in neonates of methadone and buprenorphine maintained pregnant opioid-dependent women and to provide preliminary safety and efficacy data for a larger multi-center trial."9.11Buprenorphine versus methadone in the treatment of pregnant opioid-dependent patients: effects on the neonatal abstinence syndrome. ( Chisholm, CA; Choo, RE; Crocetti, M; Dudas, R; Harrow, C; Huestis, MA; Jansson, LM; Jasinski, DR; Johnson, RE; Jones, HE; Lantz, M; Lester, BM; Milio, L; O'Grady, KE, 2005)
"To systematically review and meta-analyse studies of neurodevelopmental outcome of children born to mothers prescribed methadone in pregnancy."9.01Childhood neurodevelopment after prescription of maintenance methadone for opioid dependency in pregnancy: a systematic review and meta-analysis. ( Boardman, JP; Chappell, FM; Hamilton, R; Mactier, H; Monnelly, VJ, 2019)
"To compare the effects of morphine and methadone on length of hospital stay (LOS) or treatment (LOT) and adverse effects in infants with neonatal abstinence syndrome (NAS)."8.98Morphine and Methadone for Neonatal Abstinence Syndrome: A Systematic Review. ( Gregory, PJ; Hein, DJ; Risoldi Cochrane, Z; Slowiczek, L, 2018)
"A literature search of PubMed (1966 to March 2016) and EMBASE (1973 to March 2016) was completed using the search terms buprenorphine, methadone, pregnancy, opioid, and neonatal abstinence syndrome Priority was given to randomized controlled trials and trials directly comparing buprenorphine and methadone during pregnancy."8.93Buprenorphine Versus Methadone for Opioid Dependence in Pregnancy. ( Campbell, K; Crannage, E; Forinash, A; Noormohammadi, A; Shyken, J; Yancey, A, 2016)
"Buprenorphine and methadone are opioid-receptor agonists used as opioid substitution therapy during pregnancy to limit exposure of the fetus to cycles of opioid withdrawal and reduce the risk of infectious comorbidities of illicit opioid use."8.90Buprenorphine and methadone for opioid addiction during pregnancy. ( Mozurkewich, EL; Rayburn, WF, 2014)
"Many individuals receiving methadone maintenance treatment (MMT) for opioid addiction also require treatment for acute or chronic pain, and the presence of pain is known to have a negative impact on patient health and function."8.89Chronic and acute pain and pain management for patients in methadone maintenance treatment. ( Eyler, EC, 2013)
"This article provides an overview and discussion of the collective maternal, fetal and neonatal outcome research on women maintained on methadone or buprenorphine during pregnancy."8.88Methadone and buprenorphine for the management of opioid dependence in pregnancy. ( Finnegan, LP; Jones, HE; Kaltenbach, K, 2012)
"To determine if there is a relationship between maternal methadone dose in pregnancy and the diagnosis or medical treatment of neonatal abstinence syndrome (NAS)."8.86Methadone dose and neonatal abstinence syndrome-systematic review and meta-analysis. ( Clarke, M; Cleary, BJ; Donnelly, J; Fahey, T; Gallagher, PJ; Murphy, DJ; Strawbridge, J, 2010)
"Methadone treatment during pregnancy offers overwhelming advantages compared with the less acceptable option of medical detoxification or the unacceptably dangerous option of leaving heroin-addicted women dependent on street drugs."8.80The methadone-maintained pregnancy. ( Doberczak, TM; Jantunen, M; Kandall, SR; Stein, J, 1999)
"Results showed mean reduction in birth weight associated with heroin use: 489 g (95% CI 284-693 g), compared with methadone: 279 g (229-328 g)."8.79The relationship between maternal use of heroin and methadone and infant birth weight. ( English, DR; Holman, CD; Hulse, GK; Milne, E, 1997)
" Illicit drug use during the pregnancy was common in all groups, but in the methadone group it was most common (p = 0."8.31Buprenorphine-naloxone, buprenorphine, and methadone throughout pregnancy in maternal opioid use disorder. ( Kahila, HK; Kanervo, MM; Nikkola, EM; Rantakari, KM; Tupola, SJ, 2023)
" Methadone is recommended for the treatment of opioid use disorders during pregnancy, increasing the number of children prenatally exposed to long-acting opioids."8.31Methadone administered to rat dams during pregnancy and lactation affects the circadian rhythms of their pups. ( Bendová, Z; Novotný, J; Pačesová, D; Spišská, V, 2023)
"Methadone is used as a substitute for illicit opioids during pregnancy."8.31Long-Term Visual and Neurodevelopmental Outcomes in Two Children with Congenital Nystagmus Secondary to Methadone Exposure In utero. ( Accorsi, P; Fazzi, E; Franzoni, A; Galli, J; Loi, E; Micheletti, S; Pansera, L, 2023)
"The preterm birth rate among individuals using buprenorphine for opioid use disorder (22."8.12Risk factors for preterm birth among gravid individuals receiving buprenorphine for opioid use disorder. ( Abdelwahab, M; Cleary, EM; Petrich, M; Rood, KM; Walker, E; Wang, H, 2022)
" In early pregnancy, 10,704 pregnant persons were exposed to buprenorphine and 4387 to methadone."8.12Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy. ( Bateman, BT; Connery, HS; Davis, JM; Gray, KJ; Hernández-Díaz, S; Huybrechts, KF; Jones, HE; Lester, B; Mogun, H; Straub, L; Suarez, EA; Terplan, M, 2022)
"The aim of the study is to assess the correlation between maternal methadone dose and severity of neonatal abstinence syndrome (NAS) in infants that required pharmacological treatment for NAS."8.12Is Maternal Methadone Dose Associated with the Severity of Neonatal Abstinence Syndrome? ( Adeniyi-Jones, S; Aghai, ZH; Boelig, RC; Carola, D; Greenspan, JS; Kraft, WK; Lafferty, M; Smith, J, 2022)
"This pilot study evaluated the relationship between maternal and neonatal R- and S-methadone and R- and S-2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) exposure and the severity of neonatal abstinence syndrome (NAS)."8.02Stereoselective Analysis of Methadone and EDDP in Laboring Women and Neonates in Plasma and Dried Blood Spots and Association with Neonatal Abstinence Syndrome. ( Evrard, CA; Haas, DM; Haneline, LS; Jones, DR; Masters, AR; Metzger, IF; Quinney, SK; Thomas, AE, 2021)
"The mainstay of the management of opioid use disorder in pregnancy is with methadone or buprenorphine medication-assisted treatment."7.96Use of naltrexone in treating opioid use disorder in pregnancy. ( Katz, E; Towers, CV; Visconti, K; Weitz, B, 2020)
"To assess safety and effectiveness of transitioning from methadone to buprenorphine when necessary during pregnancy."7.88Transitioning from methadone to buprenorphine maintenance in management of opioid use disorder during pregnancy. ( Johnson, S; Martin, PR, 2018)
"Antenatal exposure to methadone or buprenorphine often causes neonatal abstinence syndrome (NAS) in newborns."7.88Antenatal methadone vs buprenorphine exposure and length of hospital stay in infants admitted to the intensive care unit with neonatal abstinence syndrome. ( Benjamin, DK; Bennett, MM; Clark, RH; Miller, ES; Murthy, K; Smith, PB; Tolia, VN, 2018)
"Our objective was to estimate the association between methadone and neonatal abstinence syndrome compared with buprenorphine using a probabilistic bias analysis to account for unmeasured confounding by severity of addiction."7.88Methadone Versus Buprenorphine for Opioid Use Dependence and Risk of Neonatal Abstinence Syndrome. ( Bodnar, LM; Caritis, SN; Lemon, LS; Platt, RW; Venkataramanan, R, 2018)
" Factors influencing adherence to buprenorphine during pregnancy have not been identified."7.88Buprenorphine medication-assisted treatment during pregnancy: An exploratory factor analysis associated with adherence. ( Catlin, D; Coker, JL; Knight, B; Ray-Griffith, S; Stowe, ZN, 2018)
"To compare neonatal abstinence syndrome prevalence and characteristics among neonates born to women prescribed buprenorphine and naloxone compared with methadone during pregnancy."7.81Buprenorphine and naloxone compared with methadone treatment in pregnancy. ( Jones, H; Seashore, C; Stringer, EM; Stuebe, AM; Thorp, J; Wiegand, SL, 2015)
"This article aims to describe neonatal outcomes, clinical correlates, and the rate for neonatal abstinence syndrome (NAS) for women on methadone maintenance therapy."7.81Maternal methadone treatment and neonatal abstinence syndrome. ( Faisal, M; Li, S; Liu, WF; Singh, K, 2015)
" The birth weights of methadone-exposed neonates of the women who tapered more than 50% were significantly higher than for the methadone-exposed neonates of the women tapering between 11 and 50%."7.81Tapering from Methadone or Buprenorphine during Pregnancy: Maternal and Neonatal Outcomes in Norway 1996-2009. ( Bakstad, B; Bjarkø, L; Ravndal, E; Skurtveit, S; Tanum, L; Waal, H; Welle-Strand, GK, 2015)
"To identify and describe infant deaths presenting suddenly and unexpectedly in whom there was a history of maternal methadone consumption or misuse of drugs during pregnancy."7.81Maternal use of methadone and risk of sudden neonatal death. ( Cohen, MC; Coombs, RC; Morley, SR, 2015)
"To evaluate neonatal abstinence syndrome (NAS) treatment outcomes achieved using an optimized methadone weaning protocol developed using pharmacokinetic (PK) modeling compared with standard methadone weaning."7.81Cohort Analysis of a Pharmacokinetic-Modeled Methadone Weaning Optimization for Neonatal Abstinence Syndrome. ( Hall, ES; Meinzen-Derr, J; Wexelblatt, SL, 2015)
"The primary objective was to determine whether oral morphine sulfate contributed to decreased length of stay, both in the hospital and neonatal intensive care unit (NICU), when compared to oral methadone for the treatment of neonatal abstinence syndrome (NAS)."7.81Retrospective chart review comparing morphine and methadone in neonates treated for neonatal abstinence syndrome. ( Hager, SJ; Spurlock, D; Young, ME, 2015)
"To evaluate the effectiveness of methadone for the treatment of neonatal abstinence syndrome when used according to a preexisting clinical pathway."7.80Effectiveness of a clinical pathway with methadone treatment protocol for treatment of neonatal abstinence syndrome following in utero drug exposure to substances of abuse*. ( Bhatt-Mehta, V; Ng, CM; Schumacher, RE, 2014)
"This report, the first description of Italian cases of nystagmus related to use of methadone during pregnancy, underlies the importance of a careful investigation of drug use in pregnancy in cases of unexplained congenital nystagmus."7.79Congenital nystagmus in two infants born from mothers exposed to methadone during pregnancy. ( Battini, R; Cioni, G; Gamucci, A; Tinelli, F, 2013)
"In a tertiary neonatal care center in Taiwan, three neonates whose mothers self-reported heroin abuse with methadone treatment during pregnancy were studied."7.78Perinatal effects of combined use of heroin, methadone, and amphetamine during pregnancy and quantitative measurement of metabolites in hair. ( Chang, YZ; Chen, JY; Chen, SC; Ng, YY; Su, PH; Yang, C, 2012)
"To identify maternal and neonatal factors that impact response to methadone therapy for neonatal abstinence syndrome."7.77Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome. ( Akinbi, H; Isemann, B; Meinzen-Derr, J, 2011)
"Determine whether infants exposed to chronic maternal methadone with abnormal intrapartum fetal heart rate (FHR) patterns are more likely to require treatment for neonatal abstinence syndrome (NAS)."7.77Association between intrapartum fetal heart rate patterns and neonatal abstinence syndrome in methadone exposed neonates. ( Albright, B; Brown, SA; Hsi, A; Leeman, LM; Rayburn, WF; Skipper, B, 2011)
"05), birth weight, and neonatal morbidities were similar regardless of the maternal methadone dose."7.77Higher maternal doses of methadone does not increase neonatal abstinence syndrome. ( Bombrys, A; Grier, M; Habli, M; Livingston, J; Pizarro, D; Sibai, B, 2011)
"The aim of this study is to better understand anticipated changes in daily methadone doses as a guide for prescription during pregnancy."7.77Changes in methadone maintenance therapy during and after pregnancy. ( Abbott, P; Albright, B; de la Torre, L; Price, S; Rayburn, W; Skipper, B, 2011)
"This study suggests that a treatment of neonatal abstinence syndrome with clonidine in omission of opiates is possible without causing short-term adverse cardiovascular effects."7.76Treatment of neonatal abstinence syndrome with clonidine and chloral hydrate. ( Bastanier, C; Beske, F; Esmaeili, A; Keinhorst, AK; Schlösser, R; Schuster, T, 2010)
"Infants born to drug-misusing mothers prescribed methadone in pregnancy are at risk of a range of visual problems, the underlying causes of which are not clear."7.76Ophthalmic, clinical and visual electrophysiological findings in children born to mothers prescribed substitute methadone in pregnancy. ( Bradnam, MS; Hamilton, R; MacKinnon, JR; Mactier, H; McGlone, L; Russell, HC, 2010)
"To estimate the relationship between maternal methadone dose and the incidence of neonatal abstinence syndrome (NAS)."7.76Relationship between maternal methadone dose at delivery and neonatal abstinence syndrome. ( Almario, CV; Baxter, JK; Berghella, V; Dysart, KC; Hayes, EJ; Seligman, NS, 2010)
"Methadone is standard pharmacotherapy for opioid-dependent pregnant women, yet the relationship between maternal methadone dose and neonatal abstinence syndrome (NAS) severity is still unclear."7.76Prenatal methadone exposure, meconium biomarker concentrations and neonatal abstinence syndrome. ( Choo, RE; Concheiro, M; Elko, A; Gray, TR; Huestis, MA; Jansson, LM; Jones, HE; Williams, E, 2010)
" This study aims to determine the infant mortality rate of infants born to women on a methadone program during pregnancy and to identify any modifiable risk factors."7.76Infant mortality among women on a methadone program during pregnancy. ( Burns, L; Conroy, E; Mattick, RP, 2010)
" This study compared the acoustic cry characteristics of infants born to mothers maintained on methadone during pregnancy with those of infants not exposed to methadone during pregnancy."7.75Acoustic cry characteristics of infants exposed to methadone during pregnancy. ( Quick, ZL; Robb, MP; Woodward, LJ, 2009)
"The purpose of this study was to examine high-dose methadone in pregnant women and its effect on the duration of neonatal abstinence syndrome."7.75High-dose methadone in pregnant women and its effect on duration of neonatal abstinence syndrome. ( Cordero, L; Gardner, DK; Lim, S; Prasad, MR; Samuels, P, 2009)
"Four hundred and fifty singleton pregnancies of drug-misusing women prescribed substitute methadone in pregnancy."7.75Maternal methadone use in pregnancy: factors associated with the development of neonatal abstinence syndrome and implications for healthcare resources. ( Dryden, C; Hepburn, M; Mactier, H; Young, D, 2009)
"Empirical evidence is needed to guide adequate postpartum pain relief of methadone and buprenorphine stabilized patients."7.75Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy. ( Dahne, J; Johnson, R; Jones, HE; Lemoine, L; Milio, L; O'Grady, K; Ordean, A; Selby, P, 2009)
"Prior studies noted elevated preterm birth (PTB) rates among opiate-addicted women treated with methadone."7.75Risk factors for preterm birth among opiate-addicted gravid women in a methadone treatment program. ( Almario, CV; Baxter, JK; Berghella, V; Dysart, KC; Seligman, NS, 2009)
"To describe the patterns of screening for hepatitis C virus (HCV) infection in methadone-maintained pregnant women and their infants."7.75Screening for hepatitis C virus infection in methadone-maintained mothers and their infants. ( An, EI; Leroi, MJ; Liu, AJ; Murray, HG; Nanan, RK; Tetstall, E, 2009)
"Methadone-maintained pregnant patients with mood disorders have compromised treatment outcomes ( [1] )."7.75The impact of mood disorders on the delivery and neonatal outcomes of methadone-maintained pregnant patients. ( Chisolm, MS; Fitzsimons, H; Heil, SH; Jones, HE; O'Grady, KE; Tuten, M, 2009)
"To examine the association between retention in methadone treatment during pregnancy and key neonatal outcomes."7.74Methadone in pregnancy: treatment retention and neonatal outcomes. ( Burns, L; Lim, K; Mattick, RP; Wallace, C, 2007)
"We determined the effect of preterm delivery on the course of neonatal abstinence syndrome (NAS) in infants born to mothers participating in a methadone maintenance program."7.74Sequela of preterm versus term infants born to mothers on a methadone maintenance program: differential course of neonatal abstinence syndrome. ( Dysart, K; Greenspan, JS; Hsieh, HC; Kaltenbach, K, 2007)
"Sixty-eight patients treated with methadone for opiate dependence during pregnancy (vaginal n=35; cesarean n=33) were matched retrospectively to control women."7.74Intrapartum and postpartum analgesia for women maintained on methadone during pregnancy. ( Benvenuto, A; Howard, D; Meyer, M; Plante, D; Wagner, K, 2007)
"Data from this non-randomized comparison suggest that buprenorphine may offer advantages for treatment of opiate dependence during pregnancy."7.74Buprenorphine and methadone treatment of opiate dependence during pregnancy: comparison of fetal growth and neonatal outcomes in two consecutive case series. ( Heilig, M; Kakko, J; Sarman, I, 2008)
"The aim of the study was to analyze the neonatal impact of a methadone maintenance program in pregnancy, and the social resources of the families involved."7.73Methadone maintenance program in pregnancy in a Swiss perinatal center (II): neonatal outcome and social resources. ( Arlettaz, R; Bucher, HU; Das-Kundu, S; Fauchère, JC; Kashiwagi, M; Lang, A, 2005)
"This study assesses the effect of higher doses of methadone during pregnancy on maternal and fetal outcomes."7.73High-dose methadone maintenance in pregnancy: maternal and neonatal outcomes. ( Anania, B; Leamon, MH; McCarthy, JJ; Parr, MS, 2005)
"Measurement of plasma methadone concentration to investigate the rate of clearance of methadone prescribed for heroin dependence in the first, second and third trimesters of pregnancy."7.73Changes to methadone clearance during pregnancy. ( Boys, A; Hay, A; Raistrick, D; Rostami-Hodjegan, A; Wolff, K, 2005)
"To assess the outcomes of infants born to mothers receiving methadone for the management of pain in pregnancy."7.72Outcomes of infants born to mothers receiving methadone for pain management in pregnancy. ( Kuschel, C; Sharpe, C, 2004)
"To assess the usefulness of cord and serum methadone concentrations at 2 days of age in predicting the severity of neonatal abstinence syndrome (NAS) in infants whose mothers received methadone during pregnancy."7.72Can methadone concentrations predict the severity of withdrawal in infants at risk of neonatal abstinence syndrome? ( Austerberry, L; Cornwell, M; Couch, R; Kuschel, CA; Rowley, RS, 2004)
"The purpose of this study is to evaluate women receiving methadone maintenance during pregnancy."7.70Methadone maintenance in pregnancy: a reappraisal. ( Britton, KA; Brizendine, E; Brown, HL; Hiett, AK; Mahaffey, D; Turnquest, MA, 1998)
"The volume of feeds, changes in infant body weight, as well as occurrence of adverse clinical effects in infants withdrawing from methadone were studied during the first month of life."7.70Hyperphagia in neonates withdrawing from methadone. ( Kastner, B; Martinez, A; Taeusch, HW, 1999)
"The authors describe their experience with methadone treatment in pregnancy."7.67Methadone in pregnancy: clinical-toxicological aspects. ( Chiarotti, M; De Giovanni, N; Falasconi, AM; Offidani, C, 1986)
" These two groups were compared with a group of women who had used narcotics in the past and were maintained on methadone during pregnancy, and with a group of drug-free women."7.67Cocaine use in pregnancy. ( Burns, KA; Burns, WJ; Chasnoff, IJ; Schnoll, SH, 1985)
"Body weight gain and food and water consumption of female rats receiving daily methadone injections (5 mg/kg) intraperitoneally prior to mating and during gestation and lactation were studied."7.66Effects of chronic methadone treatment on maternal body weight and food and water consumption in rats. ( McLaughlin, PJ; White, WJ; Zagon, IS, 1978)
"The course of pregnancy and delivery in 28 women under closely supervised methadone maintenance (group 1) was compared with that of 57 women using heroin or methadone under less controlled circumstances (group 2) and with that of 30 women free of mood-altering medications (group 3)."7.65Narcotic dependency in pregnancy. Methadone maintenance compared to use of street drugs. ( Adamsons, K; Stimmel, B, 1976)
"A retrospective, inception cohort, nonrandomized control design was employed to evaluate the effects of daily vs twice daily dosing of methadone on opiate/cocaine use, and noncompliance with urine toxicology requests in methadone-maintained pregnant women, n = 45."6.68Methadone dosing and pregnancy: impact on program compliance. ( DePetrillo, PB; Rice, JM, 1995)
" These recommendations address: antepartum issues including treatment, dosage and pharmacological considerations, medical conditions and lab tests, intrapartum issues, postpartum concerns including breastfeeding, neonatal withdrawal, and developmental effects associated with methadone."6.41Clinical management of methadone dependence during pregnancy. ( Curet, LB; Dorato, V; Wallerstedt, C; Wilbourne, P, 2001)
"For methadone, 11 cases were positive in hair, 9 in meconium and 6 in placenta and umbilical cord."5.46Bioanalysis for cocaine, opiates, methadone, and amphetamines exposure detection during pregnancy. ( Concheiro, M; Concheiro-Guisan, A; Cruz-Landeira, A; de Castro, A; Gónzalez-Colmenero, E; Lendoiro, E; López-Rivadulla, M; Macias-Cortiña, M; Peñas-Silva, P, 2017)
"Methadone use for the management of opioid dependency during pregnancy is commonplace."5.41Precision dosing of methadone during pregnancy: A pharmacokinetics virtual clinical trials study. ( Badhan, RKS; Gittins, R, 2021)
"Weight loss was less in small for gestational age compared to appropriately grown infants (p<0."5.38Postnatal weight loss in substitute methadone-exposed infants: implications for the management of breast feeding. ( Campbell, N; Dryden, C; Mactier, H; Young, D, 2012)
"Methadone maintenance treatment (MMT) is the standard treatment of choice for pregnant opiate addicts; however, data on newborn outcomes are contradictory."5.38Duration of methadone maintenance treatment during pregnancy and pregnancy outcome parameters in women with opiate addiction. ( Adelson, M; Bloch, M; Dollberg, S; Peles, E; Schreiber, S, 2012)
"Pregnancy care for these women needs to continue to develop to improve overall outcomes."5.38Maternal and neonatal outcomes following methadone substitution during pregnancy. ( Ash, A; Douiri, A; Greig, E, 2012)
" Maternal opiate dosing has been investigated with conflicting results."5.36Perinatal risk factors for the neonatal abstinence syndrome in infants born to women on methadone maintenance therapy. ( Cook, CM; Jones, MP; Liu, AJ; Murray, H; Nanan, R, 2010)
" Furthermore, late-gestation mice experienced significant increases in the [(3)H]saquinavir and [(3)H]methadone brain-to-plasma ratios 60 min after dosing relative to mid-gestation (p < 0."5.35Distribution of saquinavir, methadone, and buprenorphine in maternal brain, placenta, and fetus during two different gestational stages of pregnancy in mice. ( Coles, LD; Eddington, ND; Hassan, HE; Lee, IJ, 2009)
"Methadone levels were kept blinded from clinicians."5.31Methadone trough levels in pregnancy. ( Berghella, V; Drozdick, J; Hill, M; Kaltenbach, K, 2002)
"Traditionally, methadone maintenance therapy has been a once-daily dosing schedule."5.30Alterations in methadone metabolism during late pregnancy. ( Jarvis, MA; Kniseley, JS; Schnoll, SH; Wu-Pong, S, 1999)
" Methadone plasma concentration-time data were fit to a one-compartment pharmacokinetic model by extended least-squares regression."5.28Altered methadone pharmacokinetics in pregnancy: implications for dosing. ( Camara, P; DePetrillo, P; Dudley, M; Griffiths, W; Swift, RM, 1989)
"Newborns who are prenatally exposed to methadone are at risk for neonatal abstinence syndrome and the associated excess weight loss and poor weight gain."5.27Randomized Clinical Trial of Standard- Versus High-Calorie Formula for Methadone-Exposed Infants: A Feasibility Study. ( Baker, R; Bogen, DL; Cohlan, B; Hanusa, BH; Medoff-Cooper, B, 2018)
"Methadone and buprenorphine are recommended to treat opioid use disorders during pregnancy."5.27Prenatal exposure to methadone or buprenorphine: Early childhood developmental outcomes. ( Coyle, MG; Fischer, G; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; O'Grady, KE; Salisbury, AL; Stine, S, 2018)
" While methadone-maintenance currently is the standard of care for opioid dependence during pregnancy, research suggests that buprenorphine-maintenance may be associated with shorter infant hospital lengths of stay (LOS) relative to methadone-maintenance."5.19Design considerations for point-of-care clinical trials comparing methadone and buprenorphine treatment for opioid dependence in pregnancy and for neonatal abstinence syndrome. ( Hall, ES; Lewis, D; Marcotte, M; Theobald, J; Van Hook, J; Wexelblatt, SL; Wilder, C; Winhusen, T, 2014)
"Induction onto buprenorphine during pregnancy may be more challenging than induction onto methadone."5.17Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention. ( Coyle, MG; Fischer, G; Heil, SH; Holbrook, AM; Jones, HE; Kaltenbach, K; Martin, PR; Stine, SM, 2013)
" The objective of this study is to examine the extent to which cigarette smoking profiles differentially changed during the course of pregnancy in opioid-dependent patients receiving either double-blind methadone or buprenorphine."5.17A comparison of cigarette smoking profiles in opioid-dependent pregnant patients receiving methadone or buprenorphine. ( Acquavita, SP; Chisolm, MS; Fitzsimons, H; Heil, SH; Jansson, LM; Jones, HE; Kaltenbach, K; Leoutsakos, JM; Martin, PR; Tuten, M; Wilson-Murphy, M; Winklbaur, B, 2013)
"To identify factors that predict the expression of neonatal abstinence syndrome (NAS) in infants exposed to methadone or buprenorphine in utero."5.16Predicting treatment for neonatal abstinence syndrome in infants born to women maintained on opioid agonist medication. ( Coyle, MG; Heil, SH; Holbrook, AM; Jones, HE; Kaltenbach, K; Martin, PR; Salisbury, AL; Stine, SM, 2012)
"To compare the profile of signs of neonatal abstinence syndrome (NAS) in methadone- versus buprenorphine-exposed infants."5.16Differences in the profile of neonatal abstinence syndrome signs in methadone- versus buprenorphine-exposed neonates. ( Arria, AM; Badger, GJ; Coyle, MG; Gaalema, DE; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; Scott, TL; Stine, SM, 2012)
"Buprenorphine appears to have an acceptable safety profile for use during pregnancy."5.16Infections and obstetric outcomes in opioid-dependent pregnant women maintained on methadone or buprenorphine. ( Baxter, JK; Coyle, MG; Heil, SH; Holbrook, AM; Jones, HE; Kaltenbach, K; Martin, PR; Stine, SM, 2012)
"To examine hepatic enzyme test results throughout the course of pregnancy in women maintained on methadone or buprenorphine."5.16Effect of hepatitis C virus status on liver enzymes in opioid-dependent pregnant women maintained on opioid-agonist medication. ( Coyle, MG; Heil, SH; Holbrook, AM; Jones, HE; Kaltenbach, K; Martin, PR; McNicholas, LF; O'Grady, KE; Stine, SM, 2012)
" Methadone maintenance yielded to a significantly higher neonatal birth weight."5.15Randomized controlled trials in pregnancy: scientific and ethical aspects. Exposure to different opioid medications during pregnancy in an intra-individual comparison. ( Arria, A; Aschauer, C; Bäwert, A; Fischer, G; Jagsch, R; Jones, H; Leitich, H; Rohrmeister, K; Unger, A; Winklbaur, B, 2011)
"In order to investigate the effects of exposure to buprenorphine compared with methadone during pregnancy, a prospective multicenter study was conducted in collaboration with maternity hospitals, maintenance therapy centers, and general practitioners involved in addiction care."5.15Buprenorphine versus methadone in pregnant opioid-dependent women: a prospective multicenter study. ( Berrebi, A; Chaumerliac, C; Damase-Michel, C; Garipuy, D; Hammou, Y; Lacroix, I; Lapeyre-Mestre, M; Montastruc, JL; Schmitt, L, 2011)
"One hundred and fourteen subjects were included in the analysis, with 77 in SP (n = 51 methadone, n = 26 buprenorphine), and 37 in CT (n = 19 methadone, n = 18 buprenorphine), comparing maternal concomitant consumption during third trimester, demographic birth data, duration of treatment for neonatal abstinence syndrome (NAS), morphine dose for NAS treatment and length of hospital stay (LOS)."5.15Impact of treatment approach on maternal and neonatal outcome in pregnant opioid-maintained women. ( Aschauer, C; Ebner, N; Fischer, G; Jagsch, R; Metz, V; Pribasnig, A; Würzl, J, 2011)
"This was a secondary analysis of data collected in a prospective randomized, double-blind, double-dummy, multicenter trial (MOTHER study) that examined the comparative safety and efficacy of methadone and buprenorphine during pregnancy."5.15Are male neonates more vulnerable to neonatal abstinence syndrome than female neonates? ( Bäwert, A; Coyle, M; Fischer, G; Jagsch, R; Martin, PR; Rohrmeister, K; Unger, A; Winklbaur, B, 2011)
"Daily methadone maintenance is the standard of care for opiate dependency during pregnancy."5.14Maternal methadone dosing schedule and fetal neurobehaviour. ( Dipietro, JA; Elko, A; Jansson, LM; Kivlighan, KT; Knauer, H; Velez, M, 2009)
"Methadone, a full mu-opioid agonist, is the recommended treatment for opioid dependence during pregnancy."5.14Neonatal abstinence syndrome after methadone or buprenorphine exposure. ( Arria, AM; Coyle, MG; Fischer, G; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; O'Grady, KE; Selby, P; Stine, SM, 2010)
" Infants born to buprenorphine maintained women are not exposed to a greater proportion of the maternal dose compared with methadone and may be exposed to relatively less of the maternal dose compared with infants born to women maintained on methadone during pregnancy."5.14(R)- and (S)-methadone and buprenorphine concentration ratios in maternal and umbilical cord plasma following chronic maintenance dosing in pregnancy. ( Foster, DJ; Gordon, AL; Lopatko, OV; Somogyi, AA; White, JM, 2010)
" Free and total buprenorphine and norbuprenorphine, nicotine, opiates, cocaine, benzodiazepines, and metabolites were quantified in meconium from 10 infants born to women who had received buprenorphine during pregnancy."5.13Correlations of maternal buprenorphine dose, buprenorphine, and metabolite concentrations in meconium with neonatal outcomes. ( Choo, RE; Huestis, MA; Johnson, RE; Jones, HE; Kacinko, SL, 2008)
"The aim of the study was to evaluate the effect of substitution therapy in heroin addicted pregnant women on the course of pregnancy, perinatal outcomes and course of the neonatal abstinence syndrome."5.13Prospective randomised comparative study of the effect of buprenorphine, methadone and heroin on the course of pregnancy, birthweight of newborns, early postpartum adaptation and course of the neonatal abstinence syndrome (NAS) in women followed up in the ( Binder, T; Vavrinková, B, 2008)
"Eighteen women were assigned randomly to receive either methadone (n = 9) or buprenorphine (n = 9) during weeks 24-29 of pregnancy."5.12Methadone versus buprenorphine in pregnant addicts: a double-blind, double-dummy comparison study. ( Aschauer, H; Baewert, A; Fischer, G; Jagsch, R; Langer, M; Ortner, R; Rohrmeister, K, 2006)
" The mothers received methadone (n=22), slow-release oral morphine (n=17) or buprenorphine (n=14) throughout pregnancy."5.12Management of neonatal abstinence syndrome in neonates born to opioid maintained women. ( Baewert, A; Ebner, N; Fischer, G; Jagsch, R; Peternell, A; Rohrmeister, K; Thau, K; Winklbaur, B, 2007)
"Though methadone pharmacotherapy is the treatment of choice for opiate-dependence during pregnancy in the USA, most methadone-exposed neonates develop neonatal abstinence syndrome (NAS)."5.12Maternal vagal tone change in response to methadone is associated with neonatal abstinence syndrome severity in exposed neonates. ( Dipietro, JA; Elko, A; Jansson, LM; Velez, M, 2007)
"Treating opioid-addicted women with methadone in pregnancy increased the number of newborns suffering from neonatal abstinence syndrome (NAS)."5.11Therapy of the neonatal abstinence syndrome with tincture of opium or morphine drops. ( Birkenfeld, L; Hellmich, M; Herkenrath, P; Langenfeld, S; Müller, C; Theisohn, M, 2005)
"This study was designed to compare the neonatal abstinence syndrome (NAS) in neonates of methadone and buprenorphine maintained pregnant opioid-dependent women and to provide preliminary safety and efficacy data for a larger multi-center trial."5.11Buprenorphine versus methadone in the treatment of pregnant opioid-dependent patients: effects on the neonatal abstinence syndrome. ( Chisholm, CA; Choo, RE; Crocetti, M; Dudas, R; Harrow, C; Huestis, MA; Jansson, LM; Jasinski, DR; Johnson, RE; Jones, HE; Lantz, M; Lester, BM; Milio, L; O'Grady, KE, 2005)
"To investigate whether the neonatal abstinence syndrome (NAS) is different in children born to women maintained on slow-release morphine, compared with those maintained on methadone, and to compare additional drug consumption in these groups of women."5.09Comparison of methadone and slow-release morphine maintenance in pregnant addicts. ( Aschauer, HN; Eder, H; Etzersdorfer, P; Fischer, G; Gombas, W; Jagsch, R; Schatten, C; Schmidl-Mohl, K; Weninger, M, 1999)
"A literature search was conducted using scientific databases (PubMed, Scopus, Web of Science, and reports from international institutions) to review published articles on buprenorphine and methadone monitoring during pregnancy."5.05Monitoring Prenatal Exposure to Buprenorphine and Methadone. ( Busardò, FP; Carlier, J; Di Trana, A; Huestis, MA; La Maida, N; Pichini, S; Tittarelli, R, 2020)
"To systematically review and meta-analyse studies of neurodevelopmental outcome of children born to mothers prescribed methadone in pregnancy."5.01Childhood neurodevelopment after prescription of maintenance methadone for opioid dependency in pregnancy: a systematic review and meta-analysis. ( Boardman, JP; Chappell, FM; Hamilton, R; Mactier, H; Monnelly, VJ, 2019)
"To compare the effects of morphine and methadone on length of hospital stay (LOS) or treatment (LOT) and adverse effects in infants with neonatal abstinence syndrome (NAS)."4.98Morphine and Methadone for Neonatal Abstinence Syndrome: A Systematic Review. ( Gregory, PJ; Hein, DJ; Risoldi Cochrane, Z; Slowiczek, L, 2018)
"This study examined the obstetric health of opioid-dependent women who were treated with implant naltrexone during pregnancy, and compared them with women treated with methadone and/or buprenorphine and a cohort of non-opioid-dependent controls."4.95A Retrospective Cohort Study of Obstetric Outcomes in Opioid-Dependent Women Treated with Implant Naltrexone, Oral Methadone or Sublingual Buprenorphine, and Non-Dependent Controls. ( Hulse, G; Kelty, E, 2017)
"A literature search of PubMed (1966 to March 2016) and EMBASE (1973 to March 2016) was completed using the search terms buprenorphine, methadone, pregnancy, opioid, and neonatal abstinence syndrome Priority was given to randomized controlled trials and trials directly comparing buprenorphine and methadone during pregnancy."4.93Buprenorphine Versus Methadone for Opioid Dependence in Pregnancy. ( Campbell, K; Crannage, E; Forinash, A; Noormohammadi, A; Shyken, J; Yancey, A, 2016)
"Moderately strong evidence indicates lower risk of preterm birth, greater birth weight and larger head circumference with buprenorphine treatment of maternal opioid use disorder during pregnancy compared with methadone treatment, and no greater harms."4.93Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child. ( Amick, HR; Jones, HE; Joyce, AR; Kim, MM; Mann, AL; Murrelle, EL; Zedler, BK, 2016)
"Parents of infants with neonatal abstinence syndrome (NAS) in the NICU may have questions about the long-term consequences of prenatal exposure to methadone, both asked and unasked."4.93Long-Term Outcomes of Infants with Neonatal Abstinence Syndrome. ( Armstrong, K; Brooks, SS; Clark, L; Cline, GJ; Germain, AM; Maguire, DJ; Shaffer-Hudkins, E; Taylor, S, 2016)
" This review summarizes existing knowledge about smoking cessation treatments for pregnant women on buprenorphine or methadone, the two forms of medication-assisted treatment for opioid use disorder indicated for prenatal use."4.91Treating tobacco use disorder in pregnant women in medication-assisted treatment for an opioid use disorder: a systematic review. ( Akerman, SC; Blunt, HB; Brunette, MF; Goodman, DJ; Green, AI; Heil, SH, 2015)
"Buprenorphine and methadone are opioid-receptor agonists used as opioid substitution therapy during pregnancy to limit exposure of the fetus to cycles of opioid withdrawal and reduce the risk of infectious comorbidities of illicit opioid use."4.90Buprenorphine and methadone for opioid addiction during pregnancy. ( Mozurkewich, EL; Rayburn, WF, 2014)
"The present paper considers naltrexone to treat opioid dependence during pregnancy."4.89Naltrexone in the treatment of opioid-dependent pregnant women: the case for a considered and measured approach to research. ( Chisolm, MS; Jansson, LM; Jones, HE; Terplan, M, 2013)
" The standard of care for illicit or prescription opioid dependence during pregnancy is opioid agonist (methadone or buprenorphine) substitution therapy, which are also frequently abused."4.89Novel pharmacotherapeutic strategies for treatment of opioid-induced neonatal abstinence syndrome. ( Gauda, EB; Jones, CH; Lewis, T; McLemore, GL, 2013)
"Many individuals receiving methadone maintenance treatment (MMT) for opioid addiction also require treatment for acute or chronic pain, and the presence of pain is known to have a negative impact on patient health and function."4.89Chronic and acute pain and pain management for patients in methadone maintenance treatment. ( Eyler, EC, 2013)
" However, concerns about neonatal abstinence syndrome (NAS) in methadone-exposed neonates have resulted in efforts to withdraw women from methadone during pregnancy or to use buprenorphine, a mixed agonist/antagonist opiate in place of methadone."4.88Intrauterine abstinence syndrome (IAS) during buprenorphine inductions and methadone tapers: can we assure the safety of the fetus? ( McCarthy, JJ, 2012)
"This article provides an overview and discussion of the collective maternal, fetal and neonatal outcome research on women maintained on methadone or buprenorphine during pregnancy."4.88Methadone and buprenorphine for the management of opioid dependence in pregnancy. ( Finnegan, LP; Jones, HE; Kaltenbach, K, 2012)
"While buprenorphine produces a less severe neonatal abstinence syndrome than methadone, both methadone and buprenorphine are important parts of a complete comprehensive treatment approach for opioid-dependent pregnant women."4.88Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review. ( Arria, AM; Baewert, A; Coyle, MG; Fischer, G; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; Selby, P; Stine, SM, 2012)
"After completing this CME activity, physicians should be better able to assess the treatment options available to patients with opioid addiction during pregnancy, compare the risk/safety profiles of methadone and buprenorphine, and evaluate the recommendations and current data surrounding breast-feeding while on opioid maintenance treatment."4.88Opioid addiction in pregnancy. ( Lee-Parritz, A; Saia, K; Shainker, SA, 2012)
"This manuscript provides an overview of the current scientific literature on the impact of maternal drug use, specifically opioids and cocaine, during pregnancy on the acute and long-term outcomes of infants and toddlers from birth through age 3 years."4.86Prenatal drug exposure: infant and toddler outcomes. ( Accornero, VH; Bandstra, ES; Mansoor, E; Morrow, CE, 2010)
"To determine if there is a relationship between maternal methadone dose in pregnancy and the diagnosis or medical treatment of neonatal abstinence syndrome (NAS)."4.86Methadone dose and neonatal abstinence syndrome-systematic review and meta-analysis. ( Clarke, M; Cleary, BJ; Donnelly, J; Fahey, T; Gallagher, PJ; Murphy, DJ; Strawbridge, J, 2010)
" Examples of situations that characterise these special populations are: co-infection with hepatitis virus B and/or C, pregnancy, lipodystrophy, cardiovascular risk, renal failure, treatment of children and adolescents, immigrant health care, and the management of patients receiving methadone replacement therapy, among others."4.84[Utility of atazanavir in special populations]. ( Antela López, A, 2008)
"Methadone is a synthetic opioid that is effective for the relief of moderate-to-severe pain and for the treatment of opioid dependence."4.82Pharmacokinetics of methadone. ( Kern, SE; Lugo, RA; Satterfield, KL, 2005)
" First, women who continued to use illicit heroin throughout pregnancy; secondly, women stabilized on methadone at the time of conception or shortly after and thirdly, women who use heroin well into pregnancy with late entry into methadone treatment, or who continued to use illicit heroin during pregnancy while receiving methadone."4.80Assessing the relationship between maternal opiate use and neonatal mortality. ( English, DR; Holman, CD; Hulse, GK; Milne, E, 1998)
"In the twenty years since the first case of neonatal drug addiction (resulting from the mother's use during pregnancy of morphine, heroin, methadone, cocaine) was referred to our attention, there has been a steady increase in the number of cases per year."4.80Neonatal drug addiction. ( Fabris, C; Perathoner, C; Prandi, G; Soldi, A, 1998)
"Methadone treatment during pregnancy offers overwhelming advantages compared with the less acceptable option of medical detoxification or the unacceptably dangerous option of leaving heroin-addicted women dependent on street drugs."4.80The methadone-maintained pregnancy. ( Doberczak, TM; Jantunen, M; Kandall, SR; Stein, J, 1999)
"Results showed mean reduction in birth weight associated with heroin use: 489 g (95% CI 284-693 g), compared with methadone: 279 g (229-328 g)."4.79The relationship between maternal use of heroin and methadone and infant birth weight. ( English, DR; Holman, CD; Hulse, GK; Milne, E, 1997)
"We compared the association of methadone, buprenorphine, and short-acting opioid exposure with newborn head circumference (HC) and birth weight (BW), and evaluated gestational age (GA) as a mediator."4.31Association of medication-assisted treatment and short acting opioids with newborn head circumference and birth weight. ( Cox, DF; Craig, AK; Cutler, AJ; Gabrielson, SMB; Picarillo, AP, 2023)
" Illicit drug use during the pregnancy was common in all groups, but in the methadone group it was most common (p = 0."4.31Buprenorphine-naloxone, buprenorphine, and methadone throughout pregnancy in maternal opioid use disorder. ( Kahila, HK; Kanervo, MM; Nikkola, EM; Rantakari, KM; Tupola, SJ, 2023)
"Of 400 eligible pregnancies, 85 and 137 individuals received buprenorphine and methadone, respectively, during early pregnancy."4.31Comparative Safety Analysis of Opioid Agonist Treatment in Pregnant Women with Opioid Use Disorder: A Population-Based Study. ( Brothers, TN; Hartzema, A; Lewkowitz, AK; Meador, KJ; Pawasauskas, J; Quilliam, BJ; Wang, S; Ward, KE; Wen, X, 2023)
" In adjusted analyses assessing likelihood of initiation for individual MOUD, pregnancy status was associated with an increase in buprenorphine (adjusted odds ratio [aOR] 1."4.31Initiation and Treatment Discontinuation of Medications for Opioid Use Disorder in Pregnant People Compared With Nonpregnant People. ( Bierut, LJ; Carter, EB; Grucza, RA; Jones, HE; Kelly, JC; Martin, CE; Schiff, DM; Xu, KY, 2023)
" buprenorphine) or pregnancy status."4.31Treatment access for opioid use disorder among women with medicaid in Florida. ( Elmore, AL; Fryer, K; Marshall, J; McNeer, E; Mehra, S; Patrick, SW; Reid, CN; Salemi, JL; Sappenfield, WM, 2023)
" Key indicators for this analysis include pregnancy testing at intake, number of county jails offering methadone or buprenorphine to pregnant incarcerated persons for detoxification on admission, continuation of pre-incarceration treatment, or linkage to post-incarceration treatment."4.31United States county jail treatment and care of pregnant incarcerated persons with opioid use disorder. ( Beckwith, C; Benck, KN; Jones, AK; Nowotny, KM; Omori, M; Rubinstein, LB; Seide, K, 2023)
" Methadone is recommended for the treatment of opioid use disorders during pregnancy, increasing the number of children prenatally exposed to long-acting opioids."4.31Methadone administered to rat dams during pregnancy and lactation affects the circadian rhythms of their pups. ( Bendová, Z; Novotný, J; Pačesová, D; Spišská, V, 2023)
"Methadone is used as a substitute for illicit opioids during pregnancy."4.31Long-Term Visual and Neurodevelopmental Outcomes in Two Children with Congenital Nystagmus Secondary to Methadone Exposure In utero. ( Accorsi, P; Fazzi, E; Franzoni, A; Galli, J; Loi, E; Micheletti, S; Pansera, L, 2023)
" Research consistently demonstrates the efficacy of medications for OUD (MOUD); however, researchers have called for additional studies evaluating the safety of MOUD during pregnancy, particularly the relative safety of two commonly used MOUD medications-methadone and buprenorphine."4.12A retrospective, observational study on medication for opioid use disorder during pregnancy and risk for neonatal abstinence syndrome. ( Aujla, R; Boyars, L; Cleary, E; Douglas, E; Guille, C; Smith, C; Sujan, A, 2022)
"The preterm birth rate among individuals using buprenorphine for opioid use disorder (22."4.12Risk factors for preterm birth among gravid individuals receiving buprenorphine for opioid use disorder. ( Abdelwahab, M; Cleary, EM; Petrich, M; Rood, KM; Walker, E; Wang, H, 2022)
" Four unique themes emerged as barriers to medication utilization and adherence in the perinatal period: 1) Lack of agency and autonomy surrounding medication decisions because pregnancy or parenting status affected treatment adherence; 2) Hesitancy to use MOUD to minimize risk of newborn withdrawal; 3) Concern about increased scrutiny and potential loss of custody due to mandated child protective services reporting for opioid-exposure at delivery in Massachusetts; and 4) Perception that treatment environments, particularly methadone clinics, did not provide gender-responsive or equitable care, and standardized, inflexible visit regulations were particularly difficult to comply with in the early postpartum period."4.12"You have to take this medication, but then you get punished for taking it:" lack of agency, choice, and fear of medications to treat opioid use disorder across the perinatal period. ( Bernstein, J; Gray, JR; Greenfield, SF; Hoeppner, BB; Jones, HE; Kelly, JF; MacMillan, KDL; Muftu, S; Partridge, S; Schiff, DM; Terplan, M; Wilens, TE; Work, EC, 2022)
"Methadone (MTD) is a commonly prescribed treatment for opioid use disorder in pregnancy, despite limited information on the effects of passive exposure on fetal brain development."4.12Perinatal methadone exposure attenuates myelination and induces oligodendrocyte apoptosis in neonatal rat brain. ( Cai, J; Chu, T; Devlin Phinney, LA; Gibson, JM; Kong, M; Mellen, N; Wethall, AC; Zeng, W, 2022)
"The potential long-term developmental effects of prenatal methadone and buprenorphine exposure during pregnancy are still largely unknown."4.12Verbal and nonverbal memory in school-aged children born to opioid-dependent mothers. ( Konijnenberg, C; Melinder, A, 2022)
" Opioid exposure during pregnancy included 16 202 pregnancies exposed to codeine, 4540 to oxycodone, 1244 to tramadol, 260 to methadone (dispensed for pain), 90 to hydromorphone, and 63 to morphine compared with 25 710 exposed to hydrocodone."4.12Characteristics of Prescription Opioid Analgesics in Pregnancy and Risk of Neonatal Opioid Withdrawal Syndrome in Newborns. ( Bateman, BT; Esposito, DB; Hernández-Díaz, S; Huybrechts, KF; Mogun, H; Straub, L; Werler, MM, 2022)
" In early pregnancy, 10,704 pregnant persons were exposed to buprenorphine and 4387 to methadone."4.12Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy. ( Bateman, BT; Connery, HS; Davis, JM; Gray, KJ; Hernández-Díaz, S; Huybrechts, KF; Jones, HE; Lester, B; Mogun, H; Straub, L; Suarez, EA; Terplan, M, 2022)
"To examine the evidence for emerging treatment options, buprenorphine or clonidine, as monotherapy for the treatment of neonatal abstinence syndrome (NAS) against standards of care, morphine or methadone."4.12Emerging therapies for the treatment of neonatal abstinence syndrome. ( Bobby, LE; Frazier, LM; Gawronski, KM, 2022)
"The aim of the study is to assess the correlation between maternal methadone dose and severity of neonatal abstinence syndrome (NAS) in infants that required pharmacological treatment for NAS."4.12Is Maternal Methadone Dose Associated with the Severity of Neonatal Abstinence Syndrome? ( Adeniyi-Jones, S; Aghai, ZH; Boelig, RC; Carola, D; Greenspan, JS; Kraft, WK; Lafferty, M; Smith, J, 2022)
"In our theoretical cohort, treatment of OUD with buprenorphine during pregnancy resulted in 2413 fewer cases of neonatal opioid withdrawal syndrome, 1089 fewer preterm births, 299 fewer cases of fetal growth restriction, 32 fewer stillbirths, and 13 fewer cases of cerebral palsy compared to methadone treatment."4.12Cost effectiveness of buprenorphine vs. methadone for pregnant people with opioid use disorder. ( Caughey, AB; Hersh, AR; John, C; Robin, AM, 2022)
"Given the concerns raised regarding the effects of prenatal exposure to methadone and buprenorphine on the developmental outcomes of the children, this study assessed mental health and use of services in a national sample of school-aged children (N = 78) born to women enrolled in opioid maintenance treatment during pregnancy, compared with a group of foster children (N = 140)."4.12Mental health and use of health care services in opioid-exposed school-aged children compared to foster children. ( Eikemo, M; Lehmann, S; Muller, AE; Sarfi, M; Welle-Strand, GK, 2022)
" Treatment with buprenorphine-naloxone (compared with methadone) reduced odds of each outcome including neonatal abstinence syndrome (adjusted odds ratio: 0."4.02Opioid Use Disorder and Perinatal Outcomes. ( Homayra, F; Marchand, C; Mead, A; Min, JE; Ng, J; Nosyk, B; Piske, M; Woolner, M; Zhou, H, 2021)
"This pilot study evaluated the relationship between maternal and neonatal R- and S-methadone and R- and S-2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) exposure and the severity of neonatal abstinence syndrome (NAS)."4.02Stereoselective Analysis of Methadone and EDDP in Laboring Women and Neonates in Plasma and Dried Blood Spots and Association with Neonatal Abstinence Syndrome. ( Evrard, CA; Haas, DM; Haneline, LS; Jones, DR; Masters, AR; Metzger, IF; Quinney, SK; Thomas, AE, 2021)
"Medications for opioid use disorder, including methadone, combined with comprehensive wraparound services, are the gold standard for treatment in pregnancy."4.02Racial inequity in methadone dose at delivery in pregnant women with opioid use disorder. ( Abatemarco, DJ; Barber, C; Baxter, JK; Cruz, Y; Hand, DJ; Roman, AR; Rosenthal, EW; Short, VL, 2021)
"The number of pregnant women with OUD admitted and treated with methadone, buprenorphine or withdrawal; policies on provision of MOUD and withdrawal in pregnancy."3.96Opioid use disorder incidence and treatment among incarcerated pregnant women in the United States: results from a national surveillance study. ( Beal, L; Clarke, JG; Latkin, C; Sufrin, C; Sutherland, L; Terplan, M, 2020)
"Pregnant smokers recruited to participate in a placebo-controlled trial of bupropion for smoking cessation provided a blood sample for measurement of NMR."3.96Pregnant Smokers Receiving Opioid Agonist Therapy Have an Elevated Nicotine Metabolite Ratio: A Replication Study. ( Hand, D; Kranzler, HR; Lynch, KG; Oncken, C; Schnoll, R; Tyndale, RF; Washio, Y; Zindel, LR, 2020)
" Using imaging, immunofluorescence, multi-electrode array (MEA) and patch clamp recording techniques, we have investigated the effect of methadone, a frequently used opioid during pregnancy, on early neural development, including neuronal growth, neural network activity and synaptic transmission in hCOs."3.96Methadone interrupts neural growth and function in human cortical organoids. ( Cerf, I; Haddad, GG; Muotri, AR; Negraes, PD; Wang, J; Wu, W; Yao, H; Zhao, HW, 2020)
" Furthermore, buprenorphine is associated with milder symptoms of neonatal abstinence syndrome (NAS) compared with methadone."3.96Prevalence and Geographic Distribution of Obstetrician-Gynecologists Who Treat Medicaid Enrollees and Are Trained to Prescribe Buprenorphine. ( Culhane, J; Meisel, ZF; Nguemeni Tiako, MJ; South, E; Srinivas, SK, 2020)
"Methadone is a vital treatment for women with opioid use disorder in pregnancy."3.96Methadone, Pierre Robin sequence and other congenital anomalies: case-control study. ( Addor, MC; Barisic, I; Cleary, B; de Walle, HEK; Dolk, H; Gatt, M; Klungsoyr, K; Loane, M; Matias Dias, C; McDonnell, B; Neville, A; Pierini, A; Rissmann, A; Tucker, DF; Zurriaga, O, 2020)
"The mainstay of the management of opioid use disorder in pregnancy is with methadone or buprenorphine medication-assisted treatment."3.96Use of naltrexone in treating opioid use disorder in pregnancy. ( Katz, E; Towers, CV; Visconti, K; Weitz, B, 2020)
"There is lack of knowledge about the safety of treatment with methadone and buprenorphine as part of opioid maintenance treatment (OMT) during pregnancy."3.91Prenatal exposure to opioid maintenance treatment and neonatal outcomes: Nationwide registry studies from the Czech Republic and Norway. ( Engeland, A; Gabrhelík, R; Handal, M; Lund, IO; Mravčík, V; Nechanská, B; Skurtveit, S, 2019)
"To estimate whether methadone, buprenorphine, or detoxification treatment is the most cost-effective approach to the management of opioid use disorder (OUD) during pregnancy."3.91Methadone, Buprenorphine, or Detoxification for Management of Perinatal Opioid Use Disorder: A Cost-Effectiveness Analysis. ( Grobman, WA; Miller, ES; Premkumar, A; Terplan, M, 2019)
" We present a case report of a neonate born to a 25-year-old mother enrolled in a medication-assisted treatment program for substance use disorder who was noncompliant in prenatal care, using multiple substances throughout the pregnancy, including gabapentin and fentanyl."3.91Novel Withdrawal Symptoms of a Neonate Prenatally Exposed to a Fentanyl Analog. ( Davies, TH; Hansen, Z; Loudin, S; Murray, S; Nellhaus, EM, 2019)
"Using the data linkage between the Methadone Maintenance Treatment (MMT) register with national health insurance, national birth notification system, and birth registration system, we identified 1712 pregnancies with 20 or more gestational weeks from women enrolled in the MMT (heroin-exposed: receiving no methadone treatment during pregnancy, n = 1053 by 882 women; methadone-treated: receiving methadone for at least one day during pregnancy, n = 659 by 574 women) and their 1:10 matched pregnancies from 17,060 women without substance use disorder in the period of 2004-2013."3.91Inadequate prenatal care utilization among women with and without methadone-treated opioid use disorders in Taiwan. ( Chang, SH; Chen, CY; Fang, SY; Huang, N; Tsay, JH; Wang, IA, 2019)
"To assess safety and effectiveness of transitioning from methadone to buprenorphine when necessary during pregnancy."3.88Transitioning from methadone to buprenorphine maintenance in management of opioid use disorder during pregnancy. ( Johnson, S; Martin, PR, 2018)
"Antenatal exposure to methadone or buprenorphine often causes neonatal abstinence syndrome (NAS) in newborns."3.88Antenatal methadone vs buprenorphine exposure and length of hospital stay in infants admitted to the intensive care unit with neonatal abstinence syndrome. ( Benjamin, DK; Bennett, MM; Clark, RH; Miller, ES; Murthy, K; Smith, PB; Tolia, VN, 2018)
"Our objective was to estimate the association between methadone and neonatal abstinence syndrome compared with buprenorphine using a probabilistic bias analysis to account for unmeasured confounding by severity of addiction."3.88Methadone Versus Buprenorphine for Opioid Use Dependence and Risk of Neonatal Abstinence Syndrome. ( Bodnar, LM; Caritis, SN; Lemon, LS; Platt, RW; Venkataramanan, R, 2018)
"Methadone is used for medication-assisted treatment of heroin addiction during pregnancy."3.88Prenatal methadone exposure is associated with altered neonatal brain development. ( Anblagan, D; Bastin, ME; Boardman, JP; Cabez, MB; Cooper, ES; Mactier, H; Monnelly, VJ; Quigley, A; Semple, SI, 2018)
"Two national cohorts of women receiving opioid maintenance treatment during pregnancy showed small but not statistically significant differences in neonatal outcomes in favour of buprenorphine compared with methadone."3.88Neonatal outcomes after fetal exposure to methadone and buprenorphine: national registry studies from the Czech Republic and Norway. ( Engeland, A; Gabrhelík, R; Handal, M; Lund, IO; Mravčík, V; Nechanská, B; Skurtveit, S, 2018)
"Increased use of methadone and buprenorphine in this study supports the feasibility of use of these medications during pregnancy and uptake of clinical recommendations for women with opioid use disorder."3.88Trends and Outcomes Associated With Using Long-Acting Opioids During Delivery Hospitalizations. ( D'Alton, ME; Duffy, CR; Friedman, AM; Kern-Goldberger, AR; Landau, R; Mourad, MJ; Siddiq, Z; Wright, JD, 2018)
" When medically indicated, limiting use of multiple psychiatric medications, particularly benzodiazepines and gabapentin, during pregnancy should be considered to improve NAS outcomes."3.88Impact of psychiatric medication co-exposure on Neonatal Abstinence Syndrome severity. ( Nikita, FNU; Saia, K; Schiff, DM; Shaw, D; Shrestha, H; Thomas, Z; Thomas-Lewis, JA; Wachman, EM; Warden, AH, 2018)
" Factors influencing adherence to buprenorphine during pregnancy have not been identified."3.88Buprenorphine medication-assisted treatment during pregnancy: An exploratory factor analysis associated with adherence. ( Catlin, D; Coker, JL; Knight, B; Ray-Griffith, S; Stowe, ZN, 2018)
"The use of implant naltrexone during pregnancy was not associated with higher rates of negative birth outcomes compared with methadone- and buprenorphine-exposed neonates."3.85A Retrospective Cohort Study of Birth Outcomes in Neonates Exposed to Naltrexone in Utero: A Comparison with Methadone-, Buprenorphine- and Non-opioid-Exposed Neonates. ( Hulse, G; Kelty, E, 2017)
"To report the presentation and characteristics of strabismus in children with prenatal methadone exposure."3.85Sensorimotor outcomes in children with prenatal exposure to methadone. ( Jansson, LM; Park, HJ; Yoo, SH, 2017)
"In this cohort, women taking ≥60mg of methadone during pregnancy were more likely to remain in treatment and to provide urine samples negative for illicit drugs."3.85Association of methadone dose with substance use and treatment retention in pregnant and postpartum women with opioid use disorder. ( Hosta, D; Wilder, CM; Winhusen, T, 2017)
"Maternal buprenorphine maintenance predisposes the infant to exhibit neonatal abstinence syndrome (NAS), but there is insufficient published information regarding the nature of NAS and factors that contribute to its severity in buprenorphine-exposed infants."3.85Maternal buprenorphine treatment and infant outcome. ( DiPietro, JA; Gandotra, N; Jansson, LM; Jones, H; King, VL; McConnell, K; Millio, L; Rios, R; Spencer, N; Tuten, M; Velez, ML, 2017)
" The standard of care for pregnant women with opioid use disorder is opioid maintenance therapy including either methadone or buprenorphine, which can be initiated at any time during pregnancy."3.85Delayed villous maturation in term placentas exposed to opioid maintenance therapy: a retrospective cohort study. ( Caritis, SN; Catov, JM; Lemon, LS; Mokhtari, NB; Parks, WT; Serra, AE; Venkataramanan, R, 2017)
"Using the retrospective matched cohort study design, 396 births to women on methadone treatment during pregnancy (the methadone-treated group) and 609 to women who started methadone treatment after childbirth (the heroin-exposed group) were identified in the National Methadone Maintenance Program."3.81Comparison of adverse obstetric outcomes and maternity hospitalization among heroin-exposed and methadone-treated women in Taiwan. ( Chen, CY; Ho, IK; Lien, YT; Su, LW; Yeh, HH, 2015)
"To compare neonatal abstinence syndrome prevalence and characteristics among neonates born to women prescribed buprenorphine and naloxone compared with methadone during pregnancy."3.81Buprenorphine and naloxone compared with methadone treatment in pregnancy. ( Jones, H; Seashore, C; Stringer, EM; Stuebe, AM; Thorp, J; Wiegand, SL, 2015)
"This article aims to describe neonatal outcomes, clinical correlates, and the rate for neonatal abstinence syndrome (NAS) for women on methadone maintenance therapy."3.81Maternal methadone treatment and neonatal abstinence syndrome. ( Faisal, M; Li, S; Liu, WF; Singh, K, 2015)
" The birth weights of methadone-exposed neonates of the women who tapered more than 50% were significantly higher than for the methadone-exposed neonates of the women tapering between 11 and 50%."3.81Tapering from Methadone or Buprenorphine during Pregnancy: Maternal and Neonatal Outcomes in Norway 1996-2009. ( Bakstad, B; Bjarkø, L; Ravndal, E; Skurtveit, S; Tanum, L; Waal, H; Welle-Strand, GK, 2015)
"Pregnant women filling at least one prescription for an opioid analgesic at any time during pregnancy for whom opioid exposure characteristics including duration of therapy: short term (<30 days) or long term (≥ 30 days); timing of use: early use (only in the first two trimesters) or late use (extending into the third trimester); and cumulative dose (in morphine equivalent milligrams) were assessed."3.81Exposure to prescription opioid analgesics in utero and risk of neonatal abstinence syndrome: population based cohort study. ( Bateman, BT; Desai, RJ; Hernandez-Diaz, S; Huybrechts, KF; Kaltenbach, K; Kerzner, LS; Mogun, H; Patorno, E, 2015)
"To describe obstetrical and neonatal outcomes including neonatal abstinence syndrome (NAS) in a Canadian cohort of methadone-maintained pregnant women."3.81Obstetrical and neonatal outcomes of methadone-maintained pregnant women: a canadian multisite cohort study. ( Abrahams, R; Graves, L; Kahan, M; Kim, T; Ordean, A, 2015)
"To identify and describe infant deaths presenting suddenly and unexpectedly in whom there was a history of maternal methadone consumption or misuse of drugs during pregnancy."3.81Maternal use of methadone and risk of sudden neonatal death. ( Cohen, MC; Coombs, RC; Morley, SR, 2015)
"To evaluate neonatal abstinence syndrome (NAS) treatment outcomes achieved using an optimized methadone weaning protocol developed using pharmacokinetic (PK) modeling compared with standard methadone weaning."3.81Cohort Analysis of a Pharmacokinetic-Modeled Methadone Weaning Optimization for Neonatal Abstinence Syndrome. ( Hall, ES; Meinzen-Derr, J; Wexelblatt, SL, 2015)
"The primary objective was to determine whether oral morphine sulfate contributed to decreased length of stay, both in the hospital and neonatal intensive care unit (NICU), when compared to oral methadone for the treatment of neonatal abstinence syndrome (NAS)."3.81Retrospective chart review comparing morphine and methadone in neonates treated for neonatal abstinence syndrome. ( Hager, SJ; Spurlock, D; Young, ME, 2015)
"Our PBPK model integrating prior physiological knowledge, in vitro and in vivo data, allowed successful prediction of methadone and glyburide disposition during pregnancy."3.80Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19. ( Ke, AB; Nallani, SC; Rostami-Hodjegan, A; Unadkat, JD; Zhao, P, 2014)
"To evaluate the effectiveness of methadone for the treatment of neonatal abstinence syndrome when used according to a preexisting clinical pathway."3.80Effectiveness of a clinical pathway with methadone treatment protocol for treatment of neonatal abstinence syndrome following in utero drug exposure to substances of abuse*. ( Bhatt-Mehta, V; Ng, CM; Schumacher, RE, 2014)
"In infants of methadone-prescribed opioid-dependent mothers mean birth weight was 259 g [95% confidence interval (CI) 214-303 g; P<0."3.80Reduced fetal growth in methadone-maintained pregnancies is not fully explained by smoking or socio-economic deprivation. ( Dryden, C; Mactier, H; Shipton, D; Tappin, DM, 2014)
" Three hundred ninety women were treated between 1994 and 2009 with buprenorphine (n = 77), methadone (n = 184), or slow-release oral morphine (SROM) (n = 129) on an outpatient basis throughout their pregnancy and postpartum period."3.80Characteristics and quality of life of opioid-dependent pregnant women in Austria. ( Comer, SD; Fischer, G; Metz, VE; Pribasnig, A; Wuerzl, J, 2014)
" Flash VEPs were recorded within 3 days of birth from 100 healthy infants of drug-misusing mothers prescribed substitute methadone during pregnancy and 50 comparison infants matched for birth weight, gestation, and socioeconomic deprivation."3.79Neonatal visual evoked potentials in infants born to mothers prescribed methadone. ( Boulton, R; Bradnam, MS; Hamilton, R; Mactier, H; McCulloch, DL; McGlone, L; Weaver, LT, 2013)
"This report, the first description of Italian cases of nystagmus related to use of methadone during pregnancy, underlies the importance of a careful investigation of drug use in pregnancy in cases of unexplained congenital nystagmus."3.79Congenital nystagmus in two infants born from mothers exposed to methadone during pregnancy. ( Battini, R; Cioni, G; Gamucci, A; Tinelli, F, 2013)
"To describe the prevalence of in utero alcohol and illicit drug exposure in infants born to mothers prescribed methadone in pregnancy, and to compare the accuracy of maternal interview with infant toxicology."3.79In utero drug and alcohol exposure in infants born to mothers prescribed maintenance methadone. ( Cooper, G; Hassan, H; Mactier, H; McGlone, L, 2013)
"Methadone maintenance treatment (MMT) is the standard of care during pregnancy for opioid-dependency, showing efficacy in improving prenatal care and reducing risk of relapse."3.79Rates of fetal polydrug exposures in methadone-maintained pregnancies from a high-risk population. ( Delano, K; Gareri, J; Koren, G, 2013)
"In Norway, most opioid-dependent women are in opioid maintenance treatment (OMT) with either methadone or buprenorphine throughout pregnancy."3.79Neonatal outcomes following in utero exposure to methadone or buprenorphine: a National Cohort Study of opioid-agonist treatment of Pregnant Women in Norway from 1996 to 2009. ( Bakstad, B; Bjarkø, L; Jones, HE; Ravndal, E; Skurtveit, S; Waal, H; Welle-Strand, GK, 2013)
"Limited pharmacological data are available to guide methadone treatment during pregnancy and postpartum."3.79Pharmacologic evidence to support clinical decision making for peripartum methadone treatment. ( Bogen, DL; Friedman, CR; Hanusa, BH; Helsel, JC; Nukui, T; Perel, JM; Romkes, M; Wisner, KL, 2013)
"This study aimed to (i) describe methadone dosing before, during and after pregnancy, (ii) to compare the incidence of neonatal abstinence syndrome (NAS) between those with dose decreases and those with steady or increasing doses and (iii) to describe prescribed medication use among opioid-dependent pregnant women."3.79Methadone dosing and prescribed medication use in a prospective cohort of opioid-dependent pregnant women. ( Carmody, D; Clarke, T; Cleary, BJ; Eogan, M; Fahey, T; Gallagher, PJ; Gleeson, J; McDermott, C; Murphy, DJ; O'Connell, MP; O'Sullivan, A; Reynolds, K; White, MJ, 2013)
" For opiate-addicted pregnant women, methadone is the treatment of choice and should be maintained throughout pregnancy, despite the manageable problem of neonatal opiate withdrawal."3.79Management of the pregnant substance abusing woman. ( Sheehan, M; Sheehan, MG, 2013)
"Pregnant women in methadone maintenance therapy may have poor nutrition during pregnancy."3.78A pilot study of the nutritional status of opiate-using pregnant women on methadone maintenance therapy. ( Bodnar, LM; Bogen, DL; Hanusa, BH; Tomedi, LE; Wisner, KL, 2012)
"  Methadone use in pregnancy has been associated with adverse perinatal outcomes and neonatal abstinence syndrome (NAS)."3.78Methadone and perinatal outcomes: a prospective cohort study. ( Carmody, D; Clarke, T; Cleary, BJ; Eogan, M; Fahey, T; Gallagher, PJ; Gleeson, J; McDermott, C; Murphy, DJ; O'Connell, MP; O'Sullivan, A; White, MJ, 2012)
"One hundred fifty-two opioid-dependent pregnant women on methadone maintenance therapy (MMT) (n = 136) or buprenorphine maintenance therapy (BMT) (n = 16) during pregnancy and their neonates."3.78Opioid dependency in pregnancy and length of stay for neonatal abstinence syndrome. ( Hayes, MJ; Paul, JA; Pritham, UA, 2012)
"In a tertiary neonatal care center in Taiwan, three neonates whose mothers self-reported heroin abuse with methadone treatment during pregnancy were studied."3.78Perinatal effects of combined use of heroin, methadone, and amphetamine during pregnancy and quantitative measurement of metabolites in hair. ( Chang, YZ; Chen, JY; Chen, SC; Ng, YY; Su, PH; Yang, C, 2012)
"To identify maternal and neonatal factors that impact response to methadone therapy for neonatal abstinence syndrome."3.77Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome. ( Akinbi, H; Isemann, B; Meinzen-Derr, J, 2011)
"Determine whether infants exposed to chronic maternal methadone with abnormal intrapartum fetal heart rate (FHR) patterns are more likely to require treatment for neonatal abstinence syndrome (NAS)."3.77Association between intrapartum fetal heart rate patterns and neonatal abstinence syndrome in methadone exposed neonates. ( Albright, B; Brown, SA; Hsi, A; Leeman, LM; Rayburn, WF; Skipper, B, 2011)
"The purpose of this study was to examine the relationship among methadone maintenance treatment, perinatal outcomes, and neonatal abstinence syndrome."3.77Methadone and perinatal outcomes: a retrospective cohort study. ( Cleary, BJ; Donnelly, JM; Fahey, T; Gallagher, PJ; Murphy, DJ; Strawbridge, JD; White, MJ, 2011)
"05), birth weight, and neonatal morbidities were similar regardless of the maternal methadone dose."3.77Higher maternal doses of methadone does not increase neonatal abstinence syndrome. ( Bombrys, A; Grier, M; Habli, M; Livingston, J; Pizarro, D; Sibai, B, 2011)
"To examine the relationship between maternal opioid agonists, methadone, or buprenorphine (BPH), and concurrent psychiatric medication use on length of hospitalization (LOS) among infants with neonatal abstinence syndrome (NAS)."3.77The relationship between maternal opioid agonists and psychiatric medications on length of hospitalization for neonatal abstinence syndrome. ( Bauchner, H; Bonzagni, A; Byun, J; Newby, PK; Philipp, BL; Vreeland, J; Wachman, EM, 2011)
"Twenty-eight term infants that were exposed to methadone in utero and exhibited symptoms of neonatal abstinence syndrome (NAS) prior to hospital discharge were included into the study."3.77The impact of infant feeding method on neonatal abstinence scores of methadone-exposed infants. ( Gerlach, K; McQueen, KA; Montelpare, W; Murphy-Oikonen, J, 2011)
"This study found no differences in the pain responses of ME infants and non-exposed infants when given sucrose during heel lance procedures."3.76Efficacy of oral sucrose in infants of methadone-maintained mothers. ( Marceau, JR; Murray, H; Nanan, RK, 2010)
"This study suggests that a treatment of neonatal abstinence syndrome with clonidine in omission of opiates is possible without causing short-term adverse cardiovascular effects."3.76Treatment of neonatal abstinence syndrome with clonidine and chloral hydrate. ( Bastanier, C; Beske, F; Esmaeili, A; Keinhorst, AK; Schlösser, R; Schuster, T, 2010)
" Growth restriction was independent of the last maternal methadone dose and the cumulative methadone dose during pregnancy."3.76Growth restriction in pregnancies of opioid-dependent mothers. ( Cook, CM; Jones, MP; Liu, AJ; Nanan, R; Sithamparanathan, S, 2010)
"Infants born to drug-misusing mothers prescribed methadone in pregnancy are at risk of a range of visual problems, the underlying causes of which are not clear."3.76Ophthalmic, clinical and visual electrophysiological findings in children born to mothers prescribed substitute methadone in pregnancy. ( Bradnam, MS; Hamilton, R; MacKinnon, JR; Mactier, H; McGlone, L; Russell, HC, 2010)
"To estimate the relationship between maternal methadone dose and the incidence of neonatal abstinence syndrome (NAS)."3.76Relationship between maternal methadone dose at delivery and neonatal abstinence syndrome. ( Almario, CV; Baxter, JK; Berghella, V; Dysart, KC; Hayes, EJ; Seligman, NS, 2010)
"Methadone is standard pharmacotherapy for opioid-dependent pregnant women, yet the relationship between maternal methadone dose and neonatal abstinence syndrome (NAS) severity is still unclear."3.76Prenatal methadone exposure, meconium biomarker concentrations and neonatal abstinence syndrome. ( Choo, RE; Concheiro, M; Elko, A; Gray, TR; Huestis, MA; Jansson, LM; Jones, HE; Williams, E, 2010)
" This study aims to determine the infant mortality rate of infants born to women on a methadone program during pregnancy and to identify any modifiable risk factors."3.76Infant mortality among women on a methadone program during pregnancy. ( Burns, L; Conroy, E; Mattick, RP, 2010)
" This study compared the acoustic cry characteristics of infants born to mothers maintained on methadone during pregnancy with those of infants not exposed to methadone during pregnancy."3.75Acoustic cry characteristics of infants exposed to methadone during pregnancy. ( Quick, ZL; Robb, MP; Woodward, LJ, 2009)
"The purpose of this study was to examine high-dose methadone in pregnant women and its effect on the duration of neonatal abstinence syndrome."3.75High-dose methadone in pregnant women and its effect on duration of neonatal abstinence syndrome. ( Cordero, L; Gardner, DK; Lim, S; Prasad, MR; Samuels, P, 2009)
"Four hundred and fifty singleton pregnancies of drug-misusing women prescribed substitute methadone in pregnancy."3.75Maternal methadone use in pregnancy: factors associated with the development of neonatal abstinence syndrome and implications for healthcare resources. ( Dryden, C; Hepburn, M; Mactier, H; Young, D, 2009)
" This study investigated whether maternal methadone/buprenorphine dose and nicotine use in pregnancy affects the occurrence and duration of neonatal abstinence syndrome (NAS) in the infant."3.75Opioid maintenance treatment during pregnancy: occurrence and severity of neonatal abstinence syndrome. A national prospective study. ( Bakstad, B; Ravndal, E; Sarfi, M; Welle-Strand, GK, 2009)
"Empirical evidence is needed to guide adequate postpartum pain relief of methadone and buprenorphine stabilized patients."3.75Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy. ( Dahne, J; Johnson, R; Jones, HE; Lemoine, L; Milio, L; O'Grady, K; Ordean, A; Selby, P, 2009)
"Methadone is the therapeutic agent of choice for the treatment of opiate addiction in pregnancy."3.75The impact of cocaine and heroin on the placental transfer of methadone. ( Malek, A; Obrist, C; von Mandach, U; Wenzinger, S, 2009)
"Retrospective cohort study of 232 metropolitan and 67 rural infants born to mothers maintained on methadone throughout pregnancy for the treatment of opiate dependency, between January 2000 and December 2006."3.75Pregnancy and neonatal characteristics of opioid-dependent Indigenous Australians: a rural and metropolitan comparison. ( An, EI; Canalese, J; Liu, AJ; Nanan, R; Tetstall, E, 2009)
"Prior studies noted elevated preterm birth (PTB) rates among opiate-addicted women treated with methadone."3.75Risk factors for preterm birth among opiate-addicted gravid women in a methadone treatment program. ( Almario, CV; Baxter, JK; Berghella, V; Dysart, KC; Seligman, NS, 2009)
"To describe the patterns of screening for hepatitis C virus (HCV) infection in methadone-maintained pregnant women and their infants."3.75Screening for hepatitis C virus infection in methadone-maintained mothers and their infants. ( An, EI; Leroi, MJ; Liu, AJ; Murray, HG; Nanan, RK; Tetstall, E, 2009)
"Methadone-maintained pregnant patients with mood disorders have compromised treatment outcomes ( [1] )."3.75The impact of mood disorders on the delivery and neonatal outcomes of methadone-maintained pregnant patients. ( Chisolm, MS; Fitzsimons, H; Heil, SH; Jones, HE; O'Grady, KE; Tuten, M, 2009)
"Majority of neonates born to mothers on methadone exhibit neonatal abstinence syndrome and require pharmacological treatment."3.74Neonatal abstinence syndrome. ( Kurian, O; Serane, VT, 2008)
" Maternal and neonatal outcomes were evaluated, including cholestasis of pregnancy, preterm birth, low birth weight, neonatal intensive care unit admissions, and neonatal methadone withdrawal."3.74Chronic hepatitis C in pregnancy. ( Arora, S; Berkley, EM; Dunkelberg, JC; Leslie, KK; Qualls, C, 2008)
" Use of heroin alone during pregnancy was recorded in 51 women (50%), methadone alone in 6 (7%), and a combination of heroin and methadone in 9 (11%)."3.74Maternal and neonatal effects of substance abuse during pregnancy: our ten-year experience. ( Banovic, I; Bucat, M; Capkun, V; Roje, D; Vucinovic, M; Vucinovic, Z, 2008)
"To examine the association between retention in methadone treatment during pregnancy and key neonatal outcomes."3.74Methadone in pregnancy: treatment retention and neonatal outcomes. ( Burns, L; Lim, K; Mattick, RP; Wallace, C, 2007)
"Descriptive analysis of data in live births of women enrolled in a methadone maintenance programme in 1991-1994 (n = 78) and 1997-2001 (n = 98), including time spent in hospital, treatment for neonatal abstinence syndrome (NAS), admission to the neonatal medical unit (NMU) and follow-up for child health checks."3.74Methadone-exposed newborn infants: outcome after alterations to a service for mothers and infants. ( D'Souza, SW; Macrory, F; Miles, J; Sims, DG; Sugumar, K, 2007)
"We determined the effect of preterm delivery on the course of neonatal abstinence syndrome (NAS) in infants born to mothers participating in a methadone maintenance program."3.74Sequela of preterm versus term infants born to mothers on a methadone maintenance program: differential course of neonatal abstinence syndrome. ( Dysart, K; Greenspan, JS; Hsieh, HC; Kaltenbach, K, 2007)
"Sixty-eight patients treated with methadone for opiate dependence during pregnancy (vaginal n=35; cesarean n=33) were matched retrospectively to control women."3.74Intrapartum and postpartum analgesia for women maintained on methadone during pregnancy. ( Benvenuto, A; Howard, D; Meyer, M; Plante, D; Wagner, K, 2007)
"The objective of this study was to determine the population prevalence and correlates of neonatal abstinence syndrome among neonates born to women on methadone, using a cross-sectional analysis of linked population health data."3.74Using population data to examine the prevalence and correlates of neonatal abstinence syndrome. ( Burns, L; Mattick, RP, 2007)
"We selected 32 women in the city of Vancouver known to have used heroin or methadone during pregnancy between October 2001 and December 2002."3.74Rooming-in compared with standard care for newborns of mothers using methadone or heroin. ( Abrahams, RR; Janssen, PA; Kelly, SA; Mackintosh, J; Payne, S; Thiessen, PN, 2007)
"Statistically birth weight of newborns was significantly lowest in the group of heroin-addicted women as compared to the group receiving substitution with buprenorphine p<0."3.74[The effect of substitution therapy on the birth weight of the newborn, its postpartum adaptation, trophic and course of the neonatal abstinence syndrome]. ( Binder, T; Vavrinková, B, 2007)
"This study was undertaken to evaluate the adequacy of a hospital formulated oral morphine preparation for management of neonatal abstinence syndrome (NAS) and to compare clinical features in infants exposed to methadone or buprenorphine in utero."3.74Hospital morphine preparation for abstinence syndrome in newborns exposed to buprenorphine or methadone. ( Bues-Charbit, M; Busuttil, M; Colombini, N; Dubuc, M; Einaudi, MA; Elias, R, 2008)
"To assess potential risks related to the duration or total amount of fetal methadone exposure during gestation, we compared babies of women who conceived and maintained on methadone throughout pregnancy with babies of women who began methadone treatment during the second or third trimester."3.74Outcomes of neonates conceived on methadone maintenance therapy. ( Biles, LA; Leamon, MH; McCarthy, JJ; Stenson, G, 2008)
"Data from this non-randomized comparison suggest that buprenorphine may offer advantages for treatment of opiate dependence during pregnancy."3.74Buprenorphine and methadone treatment of opiate dependence during pregnancy: comparison of fetal growth and neonatal outcomes in two consecutive case series. ( Heilig, M; Kakko, J; Sarman, I, 2008)
"Although methadone maintenance is the standard treatment of opiate addiction in pregnancy, opinion as to its utility is divided."3.73Methadone maintenance program in a Swiss perinatal center: (I): Management and outcome of 89 pregnancies. ( Arlettaz, R; Hebisch, G; Kashiwagi, M; Lauper, U; Zimmermann, R, 2005)
"The aim of the study was to analyze the neonatal impact of a methadone maintenance program in pregnancy, and the social resources of the families involved."3.73Methadone maintenance program in pregnancy in a Swiss perinatal center (II): neonatal outcome and social resources. ( Arlettaz, R; Bucher, HU; Das-Kundu, S; Fauchère, JC; Kashiwagi, M; Lang, A, 2005)
"This study assesses the effect of higher doses of methadone during pregnancy on maternal and fetal outcomes."3.73High-dose methadone maintenance in pregnancy: maternal and neonatal outcomes. ( Anania, B; Leamon, MH; McCarthy, JJ; Parr, MS, 2005)
" Women who took heroin in later pregnancy were significantly more likely than women who were stabilised on methadone to have a baby who needed morphine (40% versus 19%), had higher mean maximum neonatal abstinence scores (NAS) (5."3.73Pregnancy outcome in women who use opiates. ( Armstrong, D; Fajemirokun-Odudeyi, O; Lindow, SW; Pairaudeau, P; Phillips, T; Sinha, C; Tutty, S, 2006)
"Measurement of plasma methadone concentration to investigate the rate of clearance of methadone prescribed for heroin dependence in the first, second and third trimesters of pregnancy."3.73Changes to methadone clearance during pregnancy. ( Boys, A; Hay, A; Raistrick, D; Rostami-Hodjegan, A; Wolff, K, 2005)
"To assess the outcomes of infants born to mothers receiving methadone for the management of pain in pregnancy."3.72Outcomes of infants born to mothers receiving methadone for pain management in pregnancy. ( Kuschel, C; Sharpe, C, 2004)
"To assess the usefulness of cord and serum methadone concentrations at 2 days of age in predicting the severity of neonatal abstinence syndrome (NAS) in infants whose mothers received methadone during pregnancy."3.72Can methadone concentrations predict the severity of withdrawal in infants at risk of neonatal abstinence syndrome? ( Austerberry, L; Cornwell, M; Couch, R; Kuschel, CA; Rowley, RS, 2004)
"The purpose of this study is to evaluate women receiving methadone maintenance during pregnancy."3.70Methadone maintenance in pregnancy: a reappraisal. ( Britton, KA; Brizendine, E; Brown, HL; Hiett, AK; Mahaffey, D; Turnquest, MA, 1998)
" She developed post-dural puncture headache (PDPH) on the third postpartum day which was managed by palliative measures: bed rest (patient's position of choice), increased hydration (water: 3 litres po per day), lysine acetyl salicylate (5."3.70Unilateral trigeminal and facial nerve palsies associated with epidural analgesia in labour. ( Agustí, M; Carrero, EJ; Fábregas, N; Fernández, C; Valldeoriola, F, 1998)
"The volume of feeds, changes in infant body weight, as well as occurrence of adverse clinical effects in infants withdrawing from methadone were studied during the first month of life."3.70Hyperphagia in neonates withdrawing from methadone. ( Kastner, B; Martinez, A; Taeusch, HW, 1999)
"Lower peak doses of TOS and shorter dosing intervals may be associated with shorter hospital stays for infants with neonatal abstinence syndrome secondary to maternal methadone treatment."3.70Shorter dosing interval of opiate solution shortens hospital stay for methadone babies. ( Jones, HC, 1999)
" Women who reduced their methadone dose during pregnancy delivered babies of significantly higher birth weight than those whose methadone dose remained the same or increased (median 3027 g, range 1780-3629 g vs 2645 g, range 580-3720 g)."3.70Outcome predictors in pregnant opiate and polydrug users. ( McCarthy, JE; Ruben, SM; Shaw, NJ; Siney, C, 1999)
" The majority of women in the CDU clinic were treated for narcotic addiction with methadone (90%) but most continued to use heroin during pregnancy (68%)."3.70The drug epidemic: effects on newborn infants and health resource consumption at a tertiary perinatal centre. ( Davis, PG; Henschke, PN; Kelly, JJ, 2000)
" The drug-dependent women had used combinations of methadone, heroin, cocaine and other drugs during pregnancy."3.69Development after prenatal exposure to cocaine, heroin and methadone. ( Akkerhuis, GW; Gunning, WB; Soepatmi, S; van Baar, AL, 1994)
"We examined the effect of methadone treatment, duration of Medicaid enrollment during pregnancy, and other maternal characteristics on receipt of prenatal care by 2,254 women infected with human immunodeficiency virus (HIV) delivering a singleton in New York state from 1985 through 1990."3.69Prenatal care of HIV-infected women: analysis of a large New York State cohort. ( Cocroft, J; Fanning, T; Hauck, W; Markson, L; Turner, BJ, 1995)
"A prospective longitudinal study on the development of children of drug-dependent mothers who used combinations of cocaine, heroin and methadone during pregnancy was carried out in Amsterdam."3.69Cognitive development at preschool-age of infants of drug-dependent mothers. ( de Graaff, BM; van Baar, A, 1994)
" Persistent weight retardation at 12 months was correlated with methadone dosage during pregnancy, but not the need for phenobarbitone therapy."3.69Infants born to narcotic dependent mothers: physical growth patterns in the first 12 months of life. ( Chant, DC; Gray, PH; Hayes, AJ; Tudehope, DI; Vance, JC, 1997)
"This spectrum of relationships supports the concept that careful reduction of the maternal methadone dosage during pregnancy under intensive medical and psychosocial surveillance may benefit the drug-exposed new-born infant clinically."3.68Relationship between maternal methadone dosage, maternal-neonatal methadone levels, and neonatal withdrawal. ( Doberczak, TM; Friedmann, P; Kandall, SR, 1993)
" Both of the mothers were on methadone maintenance for narcotic dependency prior to the diagnosis of pregnancy."3.68Diazepam abuse in pregnant women on methadone maintenance. Implications for the neonate. ( Hinderliter, SA; Sutton, LR, 1990)
"This paper describes patterns of drug use such as choice of drug, other substances abused, and route of administration in 174 women who reported methamphetamine, cocaine, heroin, or "Ts and blues" abuse during pregnancy."3.68Patterns of multiple substance abuse during pregnancy: implications for mother and fetus. ( Gilstrap, LD; Johnston, WL; Little, BB; Snell, LM, 1990)
" To conduct an exploratory study of opiate effects in humans, we compared the sex-dimorphic behavior of male and female offspring of women maintained on methadone during pregnancy to that of demographically matched control subjects."3.68Effects of prenatal methadone exposure on sex-dimorphic behavior in early school-age children. ( Johnson, HL; Meyer-Bahlburg, HF; Rosen, TS; Sandberg, DE, 1990)
" Apnea density and episodes of periodic breathing exceeded the 95th percentile for normal infants in 12 (38%) of 32 of cocaine-exposed infants vs only 1 (6%) of 18 opiate-exposed infants."3.67Prenatal cocaine exposure is associated with respiratory pattern abnormalities. ( Chasnoff, IJ; Hunt, CE; Kaplan, D; Kletter, R, 1989)
"This report describes a case in which cocaine abuse during pregnancy was related temporally to abruptio placentae, preterm labour and to rapid delivery."3.67Perinatal cocaine intoxication. ( Collins, E; Hardwick, RJ; Jeffery, H, 1989)
"To determine the effects of human immunodeficiency virus (HIV) infection on pregnancy outcomes, we prospectively studied female intravenous drug users in a methadone program in New York City."3.67Prospective study of human immunodeficiency virus infection and pregnancy outcomes in intravenous drug users. ( Davenny, K; Feingold, AR; Friedland, GH; Klein, RS; Mayers, MM; Robertson, VJ; Rogers, MF; Schoenbaum, EE; Selwyn, PA; Shulman, JF, 1989)
"Rat pups were exposed in utero to the opiates methadone or buprenorphine by administering subcutaneous injections to the mothers daily for the duration of pregnancy."3.67Effects of exposure in utero to methadone and buprenorphine on enkephalin levels in the developing rat brain. ( Olley, JE; Tiong, GK, 1988)
"A generally accepted management of heroin addiction during pregnancy is treatment with methadone, which reduces the complications of heroin addiction considerably."3.67The effect of chronic methadone treatment on intra-uterine growth of the cynomolgus monkey (Macaca fascicularis). ( Frencken, HJ; Hein, PR; Schatorjé, JS, 1988)
"In 50 infants born to women who continued to take heroin during all or part of their pregnancy the drug withdrawal symptoms were mild and were noted in 21 infants (42%)."3.67Maternal narcotic abuse and the newborn. ( Alroomi, LG; Davidson, J; Evans, TJ; Galea, P; Howat, R, 1988)
"The authors describe their experience with methadone treatment in pregnancy."3.67Methadone in pregnancy: clinical-toxicological aspects. ( Chiarotti, M; De Giovanni, N; Falasconi, AM; Offidani, C, 1986)
"Female rats were given different doses of methadone for the whole duration of pregnancy."3.67Fetal addiction to methadone: postnatal abstinence syndrome and development of visual evoked potentials. ( Onofrj, M; Pinto, F; Pola, P; Tempesta, E; Torrioli, MG, 1986)
"We studied the influence of human pregnancy on the maternal disposition and effects of methadone."3.67Altered methadone pharmacokinetics in methadone-maintained pregnant women. ( Benowitz, NL; Kreek, MJ; Pond, SM; Raghunath, J; Tong, TG, 1985)
" These two groups were compared with a group of women who had used narcotics in the past and were maintained on methadone during pregnancy, and with a group of drug-free women."3.67Cocaine use in pregnancy. ( Burns, KA; Burns, WJ; Chasnoff, IJ; Schnoll, SH, 1985)
"This article explores the issues raised by methadone maintenance during pregnancy with a focus on intervention techniques for the drug counselor."3.67When the client is pregnant: information for counselors. ( Williams, A, 1985)
"This study compares the first year's health, neurodevelopmental status, and environment of infants of drug-dependent mothers attending methadone programs during pregnancy with those of drug-dependent mothers not enrolled in treatment programs (untreated)."3.66Follow-up of methadone-treated and untreated narcotic-dependent women and their infants: health, developmental, and social implications. ( Desmond, MM; Wait, RB; Wilson, GS, 1981)
"Blood levels of ACTH, FSH, and estriol were measured throughout the estrous cycle and estriol was determined at different stages during pregnancy in Charles River CD-1 mice treated with 10 mg/kg/day of methadone or vehicle (physiological saline)."3.66Acute and subchronic effects of methadone on the blood hormonal levels of pregnant and nonpregnant Charles River CD-1 mice. ( Bui, QQ; Tran, MB; West, WL, 1983)
"The effects of maternal use of methadone during pregnancy on tests of thyroid function were studied in 14 women and their offspring."3.66Effects of methadone on thyroid function in mother, fetus, and newborn. ( Chandavasu, O; Dube, SK; Evans, HE; Glass, L; Jhaveri, RC; Khan, F; Rosenfeld, W; Salazar, JD, 1980)
"Minute ventilation, end-tidal PCO2, O2 and CO2 concentrations in expired air, pulse rate and arterial blood pressure were measured in the last half of pregnancy in eight women taking methadone daily."3.66Respiratory and hemodynamic effects of methadone in pregnant women. ( Dunham, MJ; Krall, MA; Metcalfe, J; Olsen, GD, 1980)
"Offspring from methadone-treated Wistar rats (last trimester of pregnancy), as compared to ad lib and pair fed controls, showed a reduction of body growth which continued throughout the 28-day period during which animals were observed after birth."3.66Prenatal exposure to methadone HCL in relationship to body and brain growth in the rat. ( Ford, DH; Rhines, RK, 1979)
"A review of research concerning the effects of methadone on infants born to mothers who received the drug during their pregnancy is presented."3.66The congenitally methadone-addicted infant. ( Fleming, JW; Rosser, P, 1979)
"To determine clinical and analytical feasibility of studies of narcotic disposition in the perinatal period, an initial prospective study of methadone disposition in one female, in chronic methadone treatment for heroin addiction, throughout pregnancy and in her neonate have been carried out."3.66Methadone disposition during the perinatal period in humans. ( Kreek, MJ, 1979)
"Body weight gain and food and water consumption of female rats receiving daily methadone injections (5 mg/kg) intraperitoneally prior to mating and during gestation and lactation were studied."3.66Effects of chronic methadone treatment on maternal body weight and food and water consumption in rats. ( McLaughlin, PJ; White, WJ; Zagon, IS, 1978)
" Heroin abuse declined while methadone usage increased during those years."3.65The narcotic-dependent mother: fetal and neonatal consequences. ( Albin, S; Eidelman, A; Gartner, LM; Kandall, SR; Lee, KS; Lowinson, J, 1977)
"The course of pregnancy and delivery in 28 women under closely supervised methadone maintenance (group 1) was compared with that of 57 women using heroin or methadone under less controlled circumstances (group 2) and with that of 30 women free of mood-altering medications (group 3)."3.65Narcotic dependency in pregnancy. Methadone maintenance compared to use of street drugs. ( Adamsons, K; Stimmel, B, 1976)
" Mean birthweight of infants born to mothers abusing heroin during the pregnancy was 2,490 gm, an effect primarily of intrauterine growth retardation."3.65Differential effects of maternal heroin and methadone use on birthweight. ( Albin, S; Berle, B; Eidelman, AI; Gartner, LM; Kandall, SR; Lowinson, J, 1976)
"A pregnant patient in the midtrimester of pregnancy was begun on a methadone detoxification program."3.65Fetal stress from methadone withdrawal. ( Davis, R; Gumpel, JA; Madden, J; Mejia-Zelaya, A; Zuspan, FP, 1975)
" Morphine was detected in significant amounts in maternal and fetal urine regardless of whether the mother was on a methadone program or whether she denied any use of heroin during the last trimester of pregnancy."3.65A study of factors that influence the severity of neonatal narcotic withdrawal. ( Chavez, CJ; Ostrea, EM; Strauss, ME, 1975)
"Drug addiction during pregnancy has been managed in two ways: the detoxification program and the methadone-maintenance treatment program."3.65Drug addiction in pregnancy and the neonate. ( Ackerman, BD; Blinick, G; Jerez, E; Wallach, RC, 1976)
"Methadone maintenance treatment (MMT) is the gold standard for pregnant women with opioid use disorders."2.84Newborn birth-weight of pregnant women on methadone or buprenorphine maintenance treatment: A national contingency management approach trial. ( Adelson, M; Peles, E; Sason, A; Schreiber, S, 2017)
"Opioid use disorder is a significant global issue and the rate of opioid use in women of childbearing age and pregnant women is on the rise."2.82Ophthalmic outcomes in children exposed to opioid maintenance treatment in utero: A systematic review and meta-analysis. ( Baldacchino, A; Conti, AA; Hemmati, Z, 2022)
"RR of SIDS between drug-exposed and control infants."2.82SIDS is associated with prenatal drug use: a meta-analysis and systematic review of 4 238 685 infants. ( Makarious, L; Oei, JL; Teng, A, 2022)
" Specific areas of focus elaborated by the authors include: better characterization of opioid selection and dosing in managing labor analgesia, effectiveness of different regional anesthetic techniques, non-pharmacologic management, and psycho-social support for these patients."2.82Opioid Use Disorder in Pregnant Patients. ( Nathan, N, 2022)
"Smoking during pregnancy is the leading preventable cause of poor pregnancy outcomes in the United States."2.78Illicit drug use among pregnant women enrolled in treatment for cigarette smoking cessation. ( Bernstein, IM; Gaalema, DE; Heil, SH; Higgins, ST; Pepin, CS, 2013)
"Lessons learned in research and treatment of opioid dependence demonstrate the need to include pregnant women in clinical trials."2.78Lessons learned from a comparison of evidence-based research in pregnant opioid-dependent women. ( Baewert, A; Fischer, G; Graf-Rohrmeister, K; Jagsch, R; Langer, M; Thau, K; Unger, A; Winklbaur-Hausknost, B, 2013)
"How best to measure the occurrence of adverse events during a randomized clinical trial is an issue that has not been adequately examined in the research literature."2.77Nonserious adverse events in randomized trials with opioid-dependent pregnant women: direct versus indirect measurement. ( Arria, AM; Coyle, MG; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; O'Grady, KE; Selby, P; Stine, SM, 2012)
"Buprenorphine compared with methadone appears to result in less suppression of mean fetal heart rate, fetal heart rate reactivity and the biophysical profile score after medication dosing and these findings provide support for the relative safety of buprenorphine when fetal indices are considered as part of the complete risk-benefit ratio."2.77Fetal assessment before and after dosing with buprenorphine or methadone. ( Coyle, MG; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; O'Grady, KE; Salisbury, AL; Stine, SM; Weninger, M, 2012)
" Pregnant women (and parents with children) were forced to negotiate dosing in dangerous conditions."2.72Changing Outdated Methadone Regulations That Harm Pregnant Patients. ( Jones, HE; McCarthy, JJ; Rudolf, VP; Terplan, M; von Klimo, MC, 2021)
"Intensive treatment for nicotine dependence, environmental interventions, and innovative harm reduction strategies are recommended to address the barriers to quitting observed in this population of pregnant women."2.71Motivational enhancement therapy for nicotine dependence in methadone-maintained pregnant women. ( Diclemente, C; Haug, NA; Svikis, DS, 2004)
"Methadone was first given to all patients within 24h of treatment admission."2.71Randomized controlled study transitioning opioid-dependent pregnant women from short-acting morphine to buprenorphine or methadone. ( Jasinski, DR; Johnson, RE; Jones, HE; Milio, L, 2005)
"This study evaluated a novel drug abuse treatment, the Therapeutic Workplace."2.70A reinforcement-based therapeutic workplace for the treatment of drug abuse: six-month abstinence outcomes. ( Bigelow, GE; Robles, E; Silverman, K; Stitzer, ML; Svikis, D, 2001)
"Perinatal prognosis of pregnant drug abusers is better with intensive prenatal care and substitution maintenance programs."2.70[Withdrawal syndromes of newborns of pregnant drug abusers maintained under methadone or high-dose buprenorphine: 246 cases]. ( Aubisson, S; Cneude, F; Gourarier, L; Lejeune, C; Piquet, M; Simmat-Durand, L, 2001)
"A retrospective, inception cohort, nonrandomized control design was employed to evaluate the effects of daily vs twice daily dosing of methadone on opiate/cocaine use, and noncompliance with urine toxicology requests in methadone-maintained pregnant women, n = 45."2.68Methadone dosing and pregnancy: impact on program compliance. ( DePetrillo, PB; Rice, JM, 1995)
"Opioid use during pregnancy has serious consequences for mother and baby."2.66Management and monitoring of opioid use in pregnancy. ( Ibsen, IO; Jørgensen, JS; Lamont, RF; Rausgaard, NLK; Ravn, P, 2020)
"Many patients with opioid use disorder are treated in primary care, where effective addiction treatment can be provided."2.61Opioid Use Disorder: Medical Treatment Options. ( Coffa, D; Snyder, H, 2019)
"Treatment with buprenorphine or methadone is associated with NOWS, but neither medication appears to have significant adverse effects on early childhood development."2.61Opioid Use in Pregnancy. ( Forray, A; Habecker, E; Tobon, AL, 2019)
"Women with opioid use disorder who become pregnant are a particularly vulnerable population and require a comprehensive treatment approach for mother and fetus."2.61Opioid use disorder during pregnancy: An overview. ( Carter, LC; Nicholas, JS; Read, L; Read, MA; Schmidt, E, 2019)
"Methadone is a long-acting mu-opioid receptor agonist that has been shown to increase retention in treatment programs and attendance at prenatal care while decreasing pregnancy complications."2.61Pharmacological treatment of opioid use disorder in pregnancy. ( Klie, KA; Rodriguez, CE, 2019)
"When opioid misuse rises in the United States, pregnant women and their neonates are affected."2.61Analgesia, Opioids, and Other Drug Use During Pregnancy and Neonatal Abstinence Syndrome. ( Jones, HE; Kraft, WK, 2019)
"Options for treatment of opioid dependence, acute pain management, and perioperative multimodal analgesia are discussed."2.55Peripartum Anesthetic Management of the Opioid-tolerant or Buprenorphine/Suboxone-dependent Patient. ( Pan, A; Zakowski, M, 2017)
"Methadone is a valid option, but its safety profile is not completely known."2.55Neonatal Abstinence Syndrome: Update on Diagnostic and Therapeutic Strategies. ( Agosti, M; Allegaert, K; Cavallaro, G; Fumagalli, M; Mosca, F; Raffaeli, G; Tibboel, D; Wildschut, ED, 2017)
"Pregnant women with opioid use disorder can be treated with methadone, buprenorphine, or naltrexone to reduce opioid use and improve retention to treatment."2.55Methadone, Buprenorphine, and Naltrexone for the Treatment of Opioid Use Disorder in Pregnant Women. ( Griffin, BL; Stone, RH; Todd, TJ; Tran, TH; Vest, KM, 2017)
" Recommendations are made for further research into physician/patient interactions and into optimal dosing of methadone and buprenorphine to minimize maternal/fetal withdrawal."2.55Opioid dependence and pregnancy: minimizing stress on the fetal brain. ( Fassbender, C; Finnegan, LP; Leamon, MH; McCarthy, JJ, 2017)
"Recommendations and options for treating postoperative pain in patients on methadone and buprenorphine are outlined below."2.53New Pain Management Options for the Surgical Patient on Methadone and Buprenorphine. ( Arulkumar, S; Cornett, EM; Flower, RR; Fox, CJ; Gayle, JA; Kaye, AD; Sen, S, 2016)
"Methadone has been the mainstay of maintenance treatment for nearly 50 years, but recent research has found that both methadone and buprenorphine maintenance treatments significantly improve maternal, fetal and neonatal outcomes."2.52Pharmacological Management of Opioid Use Disorder in Pregnant Women. ( Wilder, CM; Winhusen, T, 2015)
"Methadone maintenance treatment (MMT) helps individuals with an opioid use disorder abstain from or decrease use of illegal or nonmedical opiates."2.50Medication-assisted treatment with methadone: assessing the evidence. ( Daniels, AS; Delphin-Rittmon, ME; Dougherty, RH; Fullerton, CA; Ghose, SS; Kim, M; Lyman, DR; Montejano, LB; Thomas, CP, 2014)
"Buprenorphine is a newer treatment for maternal opioid addiction and appears to result in a milder withdrawal syndrome than methadone."2.50Neonatal opioid withdrawal syndrome. ( Hsi, A; Leeman, L; Sutter, MB, 2014)
"Managing opioid dependence in pregnant women is a complex and potentially challenging task."2.49Managing opioid dependence in pregnancy -- a general practice perspective. ( Arunogiri, S; Foo, L; Frei, M; Lubman, DI, 2013)
"Birth weight was higher in the buprenorphine group in the two trials that could be pooled (mean difference (MD) -365."2.49Maintenance agonist treatments for opiate-dependent pregnant women. ( Amato, L; Bellisario, C; Davoli, M; Ferri, M; Minozzi, S, 2013)
"Neonatal abstinence syndrome has become a growing concern in infants born to substance-abusing mothers in the State of Florida."2.49Pharmacologic management of neonatal abstinence syndrome in a community hospital. ( Calhoun, DA; Napolitano, A; Seng, SK; Theophilopoulos, D, 2013)
"Methadone maintenance treatment has definite advantages for the mother and is currently recommended in the UK."2.47The management of heroin misuse in pregnancy: time for a rethink? ( Mactier, H, 2011)
" With respect to the particular consumed drug substances other than opioids during pregnancy variable forms of teratogenic and toxic effects can be assigned to the baby."2.47[Pregnant opioid addicted patients and additional drug intake. Part I. Toxic effects and therapeutic consequences]. ( Havemann-Reinecke, U; Hoell, I, 2011)
"Methadone is a long-acting synthetic opioid with high affinity for various opioid receptors, especially for m-opioid receptors."2.45[Methadone treatment and its dangers]. ( Jodziūniene, L; Lazauskas, R; Reingardiene, D, 2009)
"Women using methadone for treatment of opioid dependence should not be discouraged from breastfeeding."2.44Methadone exposure during lactation. ( Finkelstein, Y; Garcia-Bournissen, F; Glatstein, MM; Koren, G, 2008)
"The management of opioid dependence during pregnancy has received considerable attention over the past three decades."2.44Opioid dependence and pregnancy. ( Fischer, G; Jung, E; Winklbaur, B, 2008)
" These recommendations address: antepartum issues including treatment, dosage and pharmacological considerations, medical conditions and lab tests, intrapartum issues, postpartum concerns including breastfeeding, neonatal withdrawal, and developmental effects associated with methadone."2.41Clinical management of methadone dependence during pregnancy. ( Curet, LB; Dorato, V; Wallerstedt, C; Wilbourne, P, 2001)
"Methadone maintenance for the treatment of opioid dependence is described in this article."2.40Opioid dependence during pregnancy. Effects and management. ( Berghella, V; Finnegan, L; Kaltenbach, K, 1998)
"With methadone treatment, there is a decline in the amount of heroin used and in the number of injections."2.40[Substitution therapy of drug addicts]. ( Kopferschmitt, J; Weber, JC, 1998)
"Although substance use has been a worldwide problem at all levels of society since ancient times, recent attention has been focused on the use of legal and illegal substances by the pregnant woman."2.38The consequences of prenatal substance use for the developing fetus, newborn, and young child. ( Behnke, M; Eyler, FD, 1993)
"Methadone has been used for substitution in the US."2.38[Drug abuse, pregnancy and HIV infection]. ( Beck, L; Bender, HG; Halberstadt, E; Hartmann, L; Jahn, K, 1991)
"Methadone maintenance is an important component of the management of many pregnant opioid addicts."2.38Narcotic use in pregnancy. ( Hoegerman, G; Schnoll, S, 1991)
"Management of patients with opioid use disorder during the acute postpartum period remains clinically challenging as obstetricians aim to mitigate postdelivery pain while optimizing recovery support."1.91A comparison of postpartum opioid consumption and opioid discharge prescriptions among opioid-naïve patients and those with opioid use disorder. ( Achu, R; Bateman, BT; Gibbs, L; Guang, Z; Holland, E; Saia, K; Spence, NZ; Wachman, EM; Werler, MM; Young, M, 2023)
"Methadone-based treatment for pregnant women with opioid use disorder is quite prevalent in the clinical environment."1.91Perturbed neurochemical and microstructural organization in a mouse model of prenatal opioid exposure: A multi-modal magnetic resonance study. ( Atwood, BK; Grecco, GG; Shahid, SS; Wu, YC, 2023)
"Medications for opioid use disorder (MOUDs), including methadone, buprenorphine and naltrexone, are associated with lower death rates and improved quality of life for people in recovery from opioid use disorder (OUD)."1.72Examining differences in retention on medication for opioid use disorder: An analysis of Ohio Medicaid data. ( Ashmead, R; Bailey, E; Bickert, T; Bonny, AE; Doogan, NJ; Mack, A; Schmidt, S; Tossone, K; Zhang, P, 2022)
" However, evidence to guide appropriate dosing of pharmacotherapy for the treatment of opioid use disorder, such as methadone, based on self-reported opioid use during pregnancy is limited."1.72Does self-reported consumption of heroin correlate with dose of methadone among pregnant people with opioid use disorder? ( Arlandson, ME; Gonzalez, AM; Patel, A; Premkumar, A, 2022)
"Characterize severity of opioid use disorder during pregnancy over time."1.72Trends in the severity of opioid use disorder during pregnancy over time. ( Bailit, JL; Sadananda, GB; Sundaresh, S, 2022)
" There were no significant differences in NOWS hospital outcomes between groups in adjusted models: transition to scheduled dosing (methadone 31."1.72Neonatal Opioid Withdrawal Syndrome: A Comparison of As-Needed Pharmacotherapy. ( Gupta, M; MacMillan, KDL; Melvin, P; Morrison, TM; Murzycki, J; O'Shea, TF; Rothstein, R; Schiff, DM; Singh, R; Van Vleet, MW; Wachman, EM, 2022)
"Mothers who screen positive for opioid abuse should be referred to a provider experienced in opioid maintenance therapy."1.62Neonatal Abstinence Syndrome: Prevention, Recognition, Treatment, and Follow-up. ( Schroeder, M; White, J, 2021)
"To determine the prevalence of substance abuse among our pregnant women and the characteristics of their pregnancies, deliveries and new-born infants."1.62Drug abuse during pregnancy and its neonatal impact. Analysis of the periods 2002-2008 and 2009-2017. ( Guarddon Pueyo, C; López-Vílchez, MÁ; Maya-Enero, S; Mur-Sierra, A, 2021)
"Methadone maintenance treatment (MMT) is the most common treatment for opioid-dependent pregnant women worldwide."1.62Prenatal methadone exposure impairs adolescent cognition and GABAergic neurodevelopment in a novel rat model of maternal methadone treatment. ( Bird, KM; Lum, JS; Millard, SJ; Newell, KA; Pallimulla, S; Wilkie, J; Wright, IM, 2021)
"Methadone is an opioid drug commonly prescribed for treating opioid use disorder in pregnant women and was found to accumulate at high levels in the fetal brain of mice, which fell quickly after birth."1.62Prenatal methadone exposure disrupts behavioral development and alters motor neuron intrinsic properties and local circuitry. ( Allen, MR; Atwood, BK; Baucum, AJ; Engleman, EA; Gao, Y; Grecco, GG; Haggerty, DL; Hoffman, H; Huang, JY; Katner, SN; Kim, J; Lu, HC; Masters, AR; Metzger, CE; Mork, BE; Morris, CW; Newell, EA; Reeves, KC; Sheets, PL; Wu, YC; Yamamoto, BK, 2021)
"Women with histories of opioid misuse face drug-related stigma, which can be amplified during pregnancy."1.62Conceptualizing stigma in contexts of pregnancy and opioid misuse: A qualitative study with women and healthcare providers in Ohio. ( Clapp, J; Howard, H; Madden, D; Spadola, C; Syvertsen, JL; Toneff, H, 2021)
" High maternal dosing of buprenorphine is associated with lower BW and HC Z-scores but dose effect is not seen with methadone."1.62Impact of opioid maintenance treatment during pregnancy on neonatal birth weight and head circumference. ( Adekola, H; Bruder, A; Kumar, N; Masten, M; Monga, R; Moustafa, ASZ; Parmar, K; Rocha, FG; Sampath, V, 2021)
"Individuals receiving medications for opioid use disorder after delivery were included in the study."1.62Methadone and buprenorphine discontinuation among postpartum women with opioid use disorder. ( Bernson, D; Bernstein, J; Bharel, M; Greenfield, SF; Hadland, SE; Hoeppner, BB; Kelly, JF; Nielsen, TC; Reddy, J; Schiff, DM; Taveras, EM; Terplan, M; Wilens, TE, 2021)
"Longer duration of medication for opioid use disorder use during pregnancy appears to be associated with improved maternal and perinatal outcomes."1.62Outcomes associated with the use of medications for opioid use disorder during pregnancy. ( Chen, Q; James, AE; Jarlenski, MP; Kelley, D; Kim, JY; Krans, EE; Rothenberger, SD, 2021)
"The increasing prevalence of opioid use disorders among pregnant and postpartum women (PPW) has generated a need for greater availability of specialized programs offering evidence-based and comprehensive substance use disorder treatment services tailored to this population."1.56Substance use disorder treatment services for pregnant and postpartum women in residential and outpatient settings. ( Ali, MM; Hinde, JM; Meinhofer, A, 2020)
"Neonatal abstinence syndrome is an array of signs and symptoms experienced by a newborn due to abrupt discontinuation of intrauterine exposure to certain drugs, primarily opioids."1.56Screening for Opioid and Stimulant Exposure In Utero Through Targeted and Untargeted Metabolomics Analysis of Umbilical Cords. ( Danell, AS; Forbes, L; Kew, K; Kuehn, D; Mamillapalli, SS; May, L; McIntyre, K; Poppenfuse, S; Ravisankar, S; Rushing, B; Smith-Joyner, A; Strom, C, 2020)
"counties, 1,889 (60."1.56Opioid Use Disorder Treatment Facilities With Programs for Special Populations. ( Alinsky, RH; Cerdá, M; Hadland, SE; Jent, VA; Marshall, BDL; Mauro, PM, 2020)
"The methadone group had a lower mean newborn birthweight (2874±459 g) and a greater incidence of low birth weight (11."1.56Comparison of buprenorphine and methadone in the management of maternal opioid use disorder in full term pregnancies. ( Davis, JA; Garretto, D; Garry, ET; Herrera, KM; Ly, V; Staszewski, CL, 2020)
"Medication for opioid use disorder (MOUD) improves both maternal and neonatal outcomes for pregnant women with opioid use disorder (OUD)."1.56Medications for opioid use disorder in pregnancy in a state women's prison facility. ( Amos, E; Jones, HE; Knittel, AK; Thorp, JM; Zarnick, S, 2020)
" In all analyses, methadone and buprenorphine dosing were evaluated as a continuous variable."1.56Delivery dose of methadone, but not buprenorphine, is associated with the risk and severity of neonatal opiate withdrawal syndrome. ( Bailit, JL; Gibson, KS; Lappen, JR; Stark, S, 2020)
"Opioid use during pregnancy is rising, with an estimated 14-22% of women obtaining an opioid prescription during pregnancy."1.56Factors associated with treatment retention in pregnant women with opioid use disorders prescribed methadone or electing non-pharmacological treatment. ( Haug, NA; Jancaitis, B; Kelpin, S; Masho, S; May, J; Svikis, D, 2020)
"Utility of the session, knowledge of PTSD, and barriers of care were evaluated through a pre- and post- session questionnaire."1.51Integrated Brief Intervention for PTSD and Substance Use in an Antepartum Unit. ( Glance, J; Gopalan, P; Shenai, N, 2019)
"Purpose With the rise of opioid use disorder (OUD) among women of childbearing age, effective care models must address the complex needs of pregnant and postpartum women with OUD."1.51Coordinating Outpatient Care for Pregnant and Postpartum Women with Opioid Use Disorder: Implications from the COACHH Program. ( Connolly, KA; Hodgins, FE; Lang, JM; Malseptic, GG; Melby, LH, 2019)
"Perinatal opioid use disorder (OUD) is a life-threatening condition that significantly impacts women in rural areas."1.51Treating perinatal opioid use disorder in rural settings: Challenges and opportunities. ( Goodman, DJ; Higgins, TM; Meyer, MC, 2019)
"Opioid addiction in pregnancy is a growing concern that has recently received a great deal of attention."1.48Invited Commentary: A Novel Strategy for Addressing Unmeasured Confounding When Comparing Opioid Agonist Therapies in Pregnancy. ( Lemon, LS, 2018)
"Preterm birth is associated with less risk of neonatal abstinence syndrome (NAS)."1.48The Role of Preterm Birth in the Association Between Opioid Maintenance Therapy and Neonatal Abstinence Syndrome. ( Bodnar, LM; Caritis, SN; Lemon, LS; Naimi, A; Platt, RW; Venkataramanan, R, 2018)
"Participants were recruited from an opioid dependence treatment center in an urban setting in the Southeastern United States."1.48Barriers and Facilitators of Breastfeeding Reported by Postpartum Women in Methadone Maintenance Therapy. ( Hicks, J; Morse, E; Wyant, DK, 2018)
" With no difference in medical and safety outcomes and a significant reduction in charges, the MAiN model can be considered safe and cost-effective."1.48Early Treatment Innovation for Opioid-Dependent Newborns: A Retrospective Comparison of Outcomes, Utilization, Quality, and Safety, 2006-2014. ( Charron, E; Chen, L; Dickes, L; Hudson, JA; Mayo, R; Sherrill, WW; Summey, J, 2018)
"Buprenorphine or methadone was initiated clinically."1.48Prenatal Treatment and Outcomes of Women With Opioid Use Disorder. ( Brogly, SB; Hernández-Díaz, S; Regan, E; Saia, KE; Werler, MM, 2018)
"Methadone was most frequently used for prenatal opioid dependence; there was little buprenorphine or buprenorphine + naloxone use."1.46Infants Born to Opioid-Dependent Women in Ontario, 2002-2014. ( Brogly, SB; Davies, G; Dow, K; Johnson, A; Lajkosz, K; Newman, A; Turner, S, 2017)
"For methadone, 11 cases were positive in hair, 9 in meconium and 6 in placenta and umbilical cord."1.46Bioanalysis for cocaine, opiates, methadone, and amphetamines exposure detection during pregnancy. ( Concheiro, M; Concheiro-Guisan, A; Cruz-Landeira, A; de Castro, A; Gónzalez-Colmenero, E; Lendoiro, E; López-Rivadulla, M; Macias-Cortiña, M; Peñas-Silva, P, 2017)
" Given the critical role of BCRP in limiting fetal exposure to drugs and xenobiotics, long-term use of these medications may affect fetal drug exposure by altering BCRP expression in human placenta."1.46Buprenorphine, Norbuprenorphine, R-Methadone, and S-Methadone Upregulate BCRP/ABCG2 Expression by Activating Aryl Hydrocarbon Receptor in Human Placental Trophoblasts. ( Liao, MZ; Mao, Q; Neradugomma, NK, 2017)
"Infant delirium is an under-recognized clinical entity in neonatal intensive care, and earlier identification and treatment could minimize morbidities associated with this condition."1.46A case of infant delirium in the neonatal intensive care unit. ( Bidegain, M; Cotten, CM; Edwards, LE; Hornik, CD; Hutchison, LB; Smith, PB, 2017)
"Opioid abuse during pregnancy is associated with fetal growth restriction, placental abruption, preterm labor, fetal death, and Neonatal Abstinence Syndrome."1.43Simultaneous quantification of buprenorphine, naloxone and phase I and II metabolites in plasma and breastmilk by liquid chromatography-tandem mass spectrometry. ( Barnes, AJ; Huestis, MA; Jansson, LM; Scheidweiler, KB; Swortwood, MJ, 2016)
"Findings were inconclusive regarding bacterial vaginosis (± candidiasis) and trichomoniasis."1.43Evaluation of the vaginal flora in pregnant women receiving opioid maintenance therapy: a matched case-control study. ( Farr, A; Hagmann, M; Holzer, I; Husslein, PW; Kiss, H; Kueronya, V; Petricevic, L, 2016)
"Hair specimen is necessary to complement blood and/or urine analyses as it permits differentiation of a single exposure from chronic use of a drug by segmentation of the hair for a stated growth period."1.42Contribution of in utero drug exposure when interpreting hair results in young children. ( Kintz, P, 2015)
"Poly-drug exposed infants and those treated for neonatal abstinence syndrome performed significantly poorer (p=0."1.42Infants of opioid-dependent mothers: neurodevelopment at six months. ( Mactier, H; McGlone, L, 2015)
"Pregnancy is an opportune time to identify opioid dependence, facilitate conversion to opioid maintenance treatment, and coordinate care with specialists in addiction medicine, behavioral health, and social services."1.42Caring for Opioid-dependent Pregnant Women: Prenatal and Postpartum Care Considerations. ( Bogen, DL; Cochran, G; Krans, EE, 2015)
"Opioid addiction is no longer a primarily urban problem."1.42Caring for pregnant opioid abusers in Vermont: A potential model for non-urban areas. ( Meyer, M; Phillips, J, 2015)
"The optimal approach to postpartum dosing among women treated with methadone maintenance is unclear."1.40Postpartum changes in methadone maintenance dose. ( Cheng, DM; Kaminetzky, LB; Pace, CA; Saia, K; Samet, JH; Walley, AY; Winter, M, 2014)
"Methadone treatment was not found to increase the treatment requirement for neonatal abstinence syndrome compared with those using heroin only (P = 0."1.39Predictors of neonatal outcomes amongst a methadone- and/or heroin-dependent population referred to a multidisciplinary Perinatal and Family Drug Health Service. ( Buckley, V; Haber, P; Razaghi, A, 2013)
"The historical and current contexts of opioid use disorders during pregnancy are reviewed."1.39Treating opioid use disorders during pregnancy: historical, current, and future directions. ( Jones, HE, 2013)
"Pregnant women meeting criteria for opioid dependence and attending an integrated care program between 1997 and 2009."1.39Integrated care for pregnant women on methadone maintenance treatment: Canadian primary care cohort study. ( Abrahams, R; Boyajian, T; Graves, L; Kahan, M; Ordean, A, 2013)
"Weight loss was less in small for gestational age compared to appropriately grown infants (p<0."1.38Postnatal weight loss in substitute methadone-exposed infants: implications for the management of breast feeding. ( Campbell, N; Dryden, C; Mactier, H; Young, D, 2012)
"Methadone maintenance treatment (MMT) is the standard treatment of choice for pregnant opiate addicts; however, data on newborn outcomes are contradictory."1.38Duration of methadone maintenance treatment during pregnancy and pregnancy outcome parameters in women with opiate addiction. ( Adelson, M; Bloch, M; Dollberg, S; Peles, E; Schreiber, S, 2012)
"The cohort of women treated for opioid dependence during pregnancy with medication-assisted therapy and delivered at a single institution between 2000 and 2006 were retrospectively identified (n = 149 women; n = 151 neonates)."1.38Development of a substance abuse program for opioid-dependent nonurban pregnant women improves outcome. ( Benvenuto, A; Howard, D; Johnston, A; Mandell, T; Metayer, J; Meyer, M; Plante, D, 2012)
"Neonatal abstinence syndrome is an expected and treatable condition that follows prenatal exposure to opioid agonists."1.38ACOG Committee Opinion No. 524: Opioid abuse, dependence, and addiction in pregnancy. ( , 2012)
"The prevalence of opioid abuse is increasing in North America."1.38Are infants exposed to methadone in utero at an increased risk for mortality? ( Bridgman-Acker, K; Kelly, LE; Koren, G; Lauwers, A; Madadi, P; Rieder, MJ, 2012)
"Pregnancy care for these women needs to continue to develop to improve overall outcomes."1.38Maternal and neonatal outcomes following methadone substitution during pregnancy. ( Ash, A; Douiri, A; Greig, E, 2012)
"Buprenorphine as maintenance treatment of opioid dependence during pregnancy has promise and may offer some benefits, but more research is needed, especially regarding induction of actively addicted women during pregnancy."1.38Treatment of opioid dependence in the setting of pregnancy. ( Martin, PR; Young, JL, 2012)
"Patterns of symptom reports may have clinical implications for maternal and fetal health during pregnancy for OM women including optimization of opioid dosing regimens, education regarding maternal nutritional intake and preventing postnatal depression, thereby ensuring maternal health and fetal development during pregnancy and enhancing mother-infant bonding and healthy child development postnatally."1.38Patterns of symptom reporting during pregnancy comparing opioid maintained and control women. ( Fisk, A; Gordon, AL; Lopatko, OV; Pearson, V; Stacey, H; White, JM; Woods, A, 2012)
"Methadone was readily identified in oral fluid at concentrations greater than 20 ng/mL following daily 30-110 mg/day methadone pharmacotherapy."1.37Methadone disposition in oral fluid during pharmacotherapy for opioid-dependence. ( Choo, RE; Dams, R; Gray, TR; Huestis, MA; Jones, HE, 2011)
"Methadone treatment is a well-recognised cause of QT interval lengthening in adults."1.37Maternal methadone therapy increases QTc interval in newborn infants. ( Bhoyar, A; Ewer, AK; Holder, G; Hussain, T; Parikh, R, 2011)
"R-Methadone concentration was 1."1.37Estimated infant exposure to enantiomer-specific methadone levels in breastmilk. ( Bogen, DL; Hanusa, BH; Helsel, JC; Perel, JM; Thompson, M; Wisner, KL, 2011)
"Methadone was eluted from sweat patches with sodium acetate buffer, followed by solid-phase extraction and quantification by gas chromatography mass spectrometry (limit of quantification > or = 10 ng/patch)."1.36Excretion of methadone in sweat of pregnant women throughout gestation after controlled methadone administration. ( Barnes, AJ; Brunet, BR; Choo, RE; Huestis, MA; Johnson, RE; Jones, HE; Mura, P, 2010)
" Maternal opiate dosing has been investigated with conflicting results."1.36Perinatal risk factors for the neonatal abstinence syndrome in infants born to women on methadone maintenance therapy. ( Cook, CM; Jones, MP; Liu, AJ; Murray, H; Nanan, R, 2010)
"Five methadone clients were interviewed at the clinic and interviews taped for transcription with consent."1.36A special type of 'hard-to-reach' patient: experiences of pregnant women on methadone. ( Calvin, C; Moriarty, H, 2010)
"Both nicotine and cocaine were always retrieved together with their main metabolite."1.35Nails of newborns in monitoring drug exposure during pregnancy. ( Bertol, E; Mari, F; Politi, L, 2008)
"During pregnancy, drug addiction represents one of the most dangerous situations."1.35Drug addiction during pregnancy: correlations between the placental health and the newborn's outcome - elaboration of a predictive score. ( Boldrini, A; Cuttano, A; Domenici, C; Ghirri, P; Nardini, V; Varese, L, 2009)
"They were also offered residential treatment before pregnancy and after the child was born."1.35Patterns in sleep-wakefulness in three-month old infants exposed to methadone or buprenorphine. ( Bakstad, B; Martinsen, H; Røislien, J; Sarfi, M; Waal, H, 2009)
"Methadone treatment is a well recognised cause of QT interval lengthening in adults."1.34Maternal methadone may cause arrhythmias in neonates. ( Ewer, AK; Hussain, T, 2007)
" In addition, methadone dosage requirements were not influenced by CYP2D6 genotypes in these subjects."1.34Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)- and racemic-methadone. ( Christrup, L; Coller, JK; Foster, DJ; Gillis, D; James, H; Joergensen, C; Somogyi, AA, 2007)
"Treatment of maternal opioid dependence with methadone is associated with a delay in fetal heart rate (FHR) accelerations in nonstress tests."1.33Effect of chronic maternal methadone therapy on intrapartum fetal heart rate patterns. ( Flores, S; McKay, J; Ramirez-Cacho, WA; Rayburn, WF; Schrader, RM, 2006)
"Buprenorphine was approved in 1996, and was subject to less restrictive conditions."1.33Buprenorphine replacement therapy: a confirmed benefit. ( , 2006)
"Symptoms of the neonatal withdrawal syndrome are excitation of the central nervous system, the gastrointestinal tract and the respiratory tract."1.33[A multidisciplinary approach is necessary in the neonatal withdrawal syndrome]. ( Clement-de Boers, A; de Vries, MC; Leeuwenburgh-Pronk, WG, 2006)
"Urine samples were analyzed for drug abuse after one month and after one year."1.33Gender differences and pregnant women in a methadone maintenance treatment (MMT) clinic. ( Adelson, M; Peles, E, 2006)
"Methadone was N-demethylated to EDDP by aromatase."1.33Methadone metabolism by early gestational age placentas. ( Ahmed, MS; Deshmukh, SV; Hankins, GD; Hieronymus, TL; Nanovskaya, TN; Vargas, R, 2006)
" This retrospective chart review provides an exploratory examination of newborns treated with either methadone or paregoric for opioid withdrawal and outlines dosage ranges and intervals, side effects, and clinical outcomes of the two regimens."1.33A chart review comparing paregoric to methadone in the treatment of neonatal opioid withdrawal. ( Wunsch, MJ, 2006)
"No miscarriages were observed in the second trimester (n = 54; incidence rate ratio = 0 compared to population norms (95% CI = 0-3."1.32Is opiate detoxification unsafe in pregnancy? ( Bearn, J; Luty, J; Nikolaou, V, 2003)
"The purpose of this study was to determine whether maternal methadone dosage correlates with neonatal withdrawal in a large heroin-addicted pregnant population."1.32Maternal methadone dose and neonatal withdrawal. ( Berghella, V; Chennat, J; Cherpes, J; Hill, MK; Kaltenbach, K; Lim, PJ, 2003)
" Daily supervised dosing by a pharmacist for the first six months resulted in significantly better treatment retention (80% vs 46%) and lower heroin use."1.32French field experience with buprenorphine. ( Auriacombe, M; Daulouède, JP; Dubernet, J; Fatséas, M; Tignol, J, 2004)
"Methadone levels were kept blinded from clinicians."1.31Methadone trough levels in pregnancy. ( Berghella, V; Drozdick, J; Hill, M; Kaltenbach, K, 2002)
"Methadone dosage was also correlated with both duration of neonatal hospitalization and neonatal abstinence score (r(s) =."1.31Relationship between maternal methadone dosage and neonatal withdrawal. ( Dashe, JS; Jackson, GL; Olscher, DA; Sheffield, JS; Todd, SJ; Wendel, GD, 2002)
"Methadone treatment programme for 50 opiate addicts has been conducted at the Department of Clinical Toxicology for a one year."1.31[Evaluation of health status in participants from a methadone treatment program in Krakow after one year of maintenance treatment]. ( Foryś, Z; Kamenczak, A; Maj, JC; Pach, J, 2001)
"Methadone exposed pups were more active and vocalized more when injected with naltrexone than with saline."1.30Neonatal withdrawal following pre- and postnatal exposure to methadone in the rat. ( Barr, GA; Hamowy, AS; Hutchings, DE; Liu, PY; Wang, S; Zmitrovich, A, 1998)
"Women with mild withdrawal symptoms were given clonidine initially, and methadone was substituted if symptoms persisted."1.30Opioid detoxification in pregnancy. ( Dashe, JS; Jackson, GL; Olscher, DA; Wendel, GD; Zane, EH, 1998)
"Traditionally, methadone maintenance therapy has been a once-daily dosing schedule."1.30Alterations in methadone metabolism during late pregnancy. ( Jarvis, MA; Kniseley, JS; Schnoll, SH; Wu-Pong, S, 1999)
"The aim of this study was to assess the influence of maternal methadone dosage on the severity of neonatal withdrawal."1.29Maternal methadone dosage and neonatal withdrawal. ( Darlow, BA; Horwood, LJ; Lennox, R; Malpas, TJ, 1995)
"Methadone was administered in the form of a slow release emulsion to nonpregnant rats and pregnant animals at early, middle, or late gestation."1.29Methadone levels in plasma, urine, and amniotic fluid of methadone-treated pregnant rats. ( Hope, W; Pierce, TL, 1994)
"47 had experienced the AIDS-related deaths of 1 or more family members and 16 of those married were HIV-seropositive."1.29HIV infection and the meaning of condoms. ( Pivnick, A, 1993)
"Higher rates of SIDS were found in infants exposed to opiates alone than in cocaine-exposed infants, but increasing rates of SIDS in cocaine-exposed infants toward the end of the decade suggested that "crack" cocaine may be linked to these increasing rates."1.29Relationship of maternal substance abuse to subsequent sudden infant death syndrome in offspring. ( Davidson, G; Gaines, J; Habel, L; Jessop, D; Kandall, SR, 1993)
" However, cocaine exposed infants did not require more medication for withdrawal management either in terms of dosage or of days treated."1.29Neonatal withdrawal syndrome in infants exposed to cocaine and methadone. ( Carroll, KM; Mayes, LC, 1996)
" The reactivity of the nonstress tests, biophysical profile scores and time needed to complete the biophysical profiled before and after methadone dosing were compared."1.29Effect of methadone on the biophysical profile. ( Cejtin, HE; Mills, A; Swift, EL, 1996)
"Illicit drug abuse, as well as smoking, are known risk factors in the development of intrauterine growth retardation."1.28[Drug dependence, smoking and fetal growth retardation]. ( Hanzal, E; Hoffmann, G; Kölbl, H, 1992)
" Methadone plasma concentration-time data were fit to a one-compartment pharmacokinetic model by extended least-squares regression."1.28Altered methadone pharmacokinetics in pregnancy: implications for dosing. ( Camara, P; DePetrillo, P; Dudley, M; Griffiths, W; Swift, RM, 1989)
"Morphine offspring were significantly different from the controls only in the 120-day-old female group."1.27Analgesic effect of opiates in offspring of opiate-treated female rats. ( Hovious, JR; Peters, MA, 1984)
"Methadone was only one among the risk factors affecting interaction."1.27A longitudinal study of offspring born to methadone-maintained women. II. Dyadic interaction and infant behavior at 4 months. ( Bernstein, V; Hans, SL; Jeremy, RJ; Marcus, J, 1984)
"Methadone was only one among several risk factors affecting interaction."1.27Dyads at risk: methadone-maintained women and their four-month-old infants. ( Bernstein, VJ; Jeremy, RJ, 1984)
"Methadone was found not to be teratogenic to the CD-1 mice."1.27Developmental toxic effect after subcutaneous injections of methadone in Charles River CD-1 mice. ( Bui, QQ; Sperling, F; West, WL, 1983)
"85% of the newborns had withdrawal symptoms and 12% had convulsions the severity of which was not correlated with the type of drug abuse."1.27Investigation of 89 children born by drug-dependent mothers. I. Neonatal course. ( Andersen, GE; Buckley, W; Friis-Hansen, B; Olofsson, M, 1983)
"Naloxone was apparently innocuous in non-dependent neonates."1.27Postnatal abstinence or acute toxicity can account for morbidity in developmental studies with opiates. ( Lichtblau, L; Sparber, SB, 1983)
"There are multiple causes for intrauterine growth retardation but one etiology proposed is maternal drugs."1.27Maternal drug therapy: effect on fetal and neonatal growth and neurobehavior. ( Hill, RM; Tennyson, LM, 1986)
"The increased rate of prematurity, intrauterine growth retardation, and perinatal complications associated with perinatal exposure to cocaine or methamphetamine was greater than that predicted by coexisting risk factors and was consistent with the pharmacologic properties of these drugs."1.27Perinatal cocaine and methamphetamine exposure: maternal and neonatal correlates. ( Dixon, SD; Oro, AS, 1987)
" The same dosage levels of BP and methadone were also given to pseudopregnant rats (PSP) with an induced decidual cell reaction (DCR) in an attempt to distinguish whether adverse effects occur in the maternal or fetal compartment or both."1.27A comparative study of the reproductive effects of methadone and benzo[a]pyrene in the pregnant and pseudopregnant rat. ( Bui, QQ; Tran, MB; West, WL, 1986)
" These data suggest that maternal drug abuse and increased methadone dosage during pregnancy may predispose infants to the development of strabismus."1.27Occurrence of strabismus in infants born to drug-dependent women. ( Calhoun, JH; Ehrlich, S; Finnegan, LP; Matteucci, T; Nelson, LB, 1987)
"in methadone offspring was not different from controls."1.27Opiate self-administration in adult offspring of methadone-treated female rats. ( Hovious, JR; Peters, MA, 1985)
"The use of epidural methadone for postoperative pain relief is advocated, both in view of its analgesic potency and of the low incidence of urinary disturbances."1.27Urinary function during epidural analgesia with methadone and morphine in post-cesarean section patients. ( Drenger, B; Evron, S; Magora, F; Samueloff, A; Simon, A, 1985)
"Methadone was acquired by the perinatal guinea pig both transplacentally and via the milk, more agent being obtained by the former route."1.26Disposition of maternally-administered methadone and its effects on hepatic drug-metabolizing functions in perinatal guinea pigs. ( Ecobichon, DJ; Pak, RC, 1982)
"Methadone binding was determined by use of equilibrium dialysis with (3H)-methadone."1.26The relationship between maternal and fetal plasma protein binding of methadone in the ewe during the third trimester. ( McFarland, JW; Szeto, HH; Umans, HR; Umans, JG, 1982)
"Morphine and methadone were infused at constant rates to the mother and fetus, and steady-state maternal and fetal plasma concentrations of the drugs were determined by radioimmunoassay."1.26A comparison of morphine and methadone disposition in the maternal-fetal unit. ( McFarland, J; Szeto, HH; Umans, JG, 1982)
"Methadone appears to cause deficits in behavioral development which can be detected at weaning."1.26Methadone exposure in utero: effects on open-field activity in weanling rats. ( Freeman, PR, 1980)
"Early withdrawal symptoms persisted for three to four months, and mean growth parameters continued along their respective percentiles."1.26Early growth patterns of methadone-addicted infants. ( Burns, WJ; Chasnoff, IJ; Hatcher, R, 1980)
"This incidence of SIDS was 5."1.26Sudden unexpected death in infants of narcotic-dependent mothers. ( Falciglia, H; Kandall, SR; Rajegowda, BK, 1978)
" Both dose-response and time-duration studies were conducted."1.26Morphine and methadone-induced antinociception in rats permanently depleted of brain dopamine. ( Elchisak, MA; Harry, GJ; Rosecrans, JA, 1977)
"Previous studies have shown that acute administration of methadone to male rats prior to mating results in adverse effects on their progeny, particularly decreased birth weights and increased neonatal mortality."1.26Chronic methadone administration to male rats: tolerance to adverse effects on sires and their progeny. ( Joffe, JM; Peterson, JM; Smith, SM; Soyka, LF, 1978)
" It is suggested that reduction of methadone dosage in late pregnancy results in reduced incidence of withdrawal but must be carefully carried out."1.26Observation and treatment of neonatal narcotic withdrawal. ( Chappel, JN; Davis, R; Gumpel, J; Madden, JD; Mejia, A; Zuspan, F, 1977)
"Body weights were reduced in drug-treated mothers during gestation and the first 2 weeks of lactation."1.26Effect of chronic maternal methadone exposure on perinatal development. ( McLaughlin, PJ; Zagon, IS, 1977)
"The L/S ratios in drug addiction methadone pregnancies and diabetic pregnancies do not have a high degree of correlation with normal L/S ratios after 36 weeks of gestation and are often low."1.26Amniotic fluid and fetal maturity. ( Singh, EJ; Zuspan, FP, 1976)
"Methadone was administered daily to pregnant or nursing rats, or directly to neonates, and the effects on brain and heart weights and ornithine decarboxylase (ODC) activities were determined during postnatal development."1.26Effects of neonatal or maternal methadone administration on ornithine decarboxylase activity in brain and heart of developing rats. ( Bartolomé, M; Lau, C; Slotkin, TA, 1976)
" In the mothers, no significant differences were found with respect to dosage and duration of methadone treatment and years of heroin abuse."1.26Cytogenetics of methadone-managed and heroin-addicted pregnant women and their newborn infants. ( Amarose, AP; Norusis, MJ, 1976)
"Neonatal withdrawal symptoms appear to be related to individual variation in maternal metabolism of the drug, placental transfer of methadone, and most importantly, to the individual variations in the rate of excretion of methadone as reflected in the neonatal plasma t 1/2."1.26Pharmacologic observations on the neonatal withdrawal syndrome. ( Pippenger, CE; Rosen, TS, 1976)
" No significant association was found between maternal dosage of methadone in the last trimester of pregnancy and lentth of gestation, birth weight, or the reported presence of withdrawal symptoms in the neonate."1.25Results of 313 consecutive live births of infants delivered to patients in the New York City Methadone Maintenance Treatment Program. ( Bashkow, S; Calko, D; Newman, RG, 1975)
"The chronic administration of dl-methadone to female rats during gestation results in the simultaneous administration of the drug to the unborn fetus."1.25Development of a "blood-brain barrier" to methadone in the newborn rat. ( Peters, MA, 1975)
"Several cases of chronic unsuspected infections in addicts' infants are reported, raising the question of the significance of undiagnosed infection as it affects growth."1.25Somatic growth effects of perinatal addiction. ( Wilson, GS, 1975)

Research

Studies (1,026)

TimeframeStudies, this research(%)All Research%
pre-1990365 (35.58)18.7374
1990's104 (10.14)18.2507
2000's142 (13.84)29.6817
2010's296 (28.85)24.3611
2020's119 (11.60)2.80

Authors

AuthorsStudies
Piske, M1
Homayra, F1
Min, JE1
Zhou, H2
Marchand, C1
Mead, A1
Ng, J1
Woolner, M1
Nosyk, B1
Chan, B1
Bougatsos, C1
Priest, KC1
McCarty, D1
Grusing, S1
Chou, R1
Sujan, A1
Cleary, E1
Douglas, E1
Aujla, R1
Boyars, L2
Smith, C1
Guille, C3
Devlin, LA2
Young, LW1
Kraft, WK3
Wachman, EM10
Czynski, A2
Merhar, SL1
Winhusen, T5
Jones, HE58
Poindexter, BB1
Wakschlag, LS1
Salisbury, AL5
Matthews, AG1
Davis, JM5
Knypinski, J1
Vorawandthanachai, T1
Wolfe, DS1
Staszewski, C1
Herrera, KM2
Kertowidjojo, E1
Ly, V2
Iovino, N1
Garretto, D2
Kaplan, C1
Persad, MD1
Garry, DJ1
Zhang, P1
Tossone, K1
Ashmead, R1
Bickert, T1
Bailey, E1
Doogan, NJ1
Mack, A1
Schmidt, S1
Bonny, AE1
Schroeder, M1
White, J2
Chighine, A1
Porcu, M1
Ferino, G1
Lenigno, N1
Trignano, C1
d'Aloja, E1
Locci, E1
Frank, CJ1
Morrison, L1
Abdelwahab, M1
Petrich, M1
Wang, H4
Walker, E1
Cleary, EM1
Rood, KM1
Gonzalez, AM1
Arlandson, ME1
Patel, A1
Premkumar, A2
Sundaresh, S1
Sadananda, GB1
Bailit, JL3
Grecco, GG5
Haggerty, DL2
Reeves, KC2
Gao, Y4
Maulucci, D1
Atwood, BK5
Hemmati, Z1
Conti, AA1
Baldacchino, A1
Schiff, DM8
Work, EC1
Muftu, S1
Partridge, S1
MacMillan, KDL3
Gray, JR1
Hoeppner, BB3
Kelly, JF3
Greenfield, SF2
Wilens, TE4
Terplan, M15
Bernstein, J3
Makarious, L1
Teng, A1
Oei, JL1
Morrison, TM1
Melvin, P1
Singh, R1
Murzycki, J1
Van Vleet, MW1
Rothstein, R1
O'Shea, TF1
Gupta, M1
Jarlenski, M1
Chen, Q3
Gao, A1
Rothenberger, SD2
Krans, EE7
Gibson, JM1
Chu, T2
Zeng, W1
Wethall, AC1
Kong, M1
Mellen, N2
Devlin Phinney, LA1
Cai, J2
Tabatabaeepour, N1
Morgan, JR2
Jalali, A1
Kapadia, SN1
Meinhofer, A3
Nguemeni Tiako, MJ2
Friedman, A1
South, EC1
Epstein, RL1
Meisel, ZF2
Kinsella, M1
Halliday, LOE1
Shaw, M1
Capel, Y1
Nelson, SM1
Kearns, RJ1
Konijnenberg, C9
Melinder, A9
Esposito, DB1
Huybrechts, KF6
Werler, MM4
Straub, L4
Hernández-Díaz, S8
Mogun, H5
Bateman, BT7
Gamble, ME1
Marfatia, R1
Diaz, MR1
Pasman, E1
Lee, G2
Kollin, R1
Rodriguez, B1
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Packham, DR1
Cunningham, AL1
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Davenny, K1
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Mayers, MM1
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Rogers, MF1
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Clinical Trials (21)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Fetal Exposure to Cannabinoids: Exposure, Methylation and Neurodevelopmental Effects[NCT04422600]72 participants (Actual)Observational [Patient Registry]2020-02-26Completed
Comparison of Buprenorphine vs Buprenorphine/Naloxone on the Effects of Maternal Symptomatology[NCT03740243]Phase 40 participants (Actual)Interventional2018-11-30Withdrawn (stopped due to No enrollment)
Maternal Opioid Treatment: Human Experimental Research[NCT00271219]Phase 3175 participants (Actual)Interventional2005-07-31Completed
A Pilot Randomized Comparative Effectiveness Clinical Trial of Buprenorphine vs. Methadone for the Treatment of Opioid Dependence in Pregnancy.[NCT03098407]55 participants (Actual)Interventional2017-04-20Completed
MOms in REcovery (MORE): Defining Optimal Care for Pregnant Women and Infants[NCT04251208]444 participants (Actual)Observational2019-07-30Active, not recruiting
Improving Alcohol and Substance Use Care Access, Outcomes, and Equity During the Reproductive Years: A Type 1 Hybrid Trial in Family Planning Clinics[NCT05910580]600 participants (Anticipated)Interventional2024-04-01Not yet recruiting
PRevention Of Methamphetamine Use Among Postpartum Women Trial (PROMPT)[NCT05128071]Early Phase 140 participants (Anticipated)Interventional2022-02-04Recruiting
Vagal Tone and Neonatal Abstinence Syndrome[NCT00496951]65 participants (Actual)Observational2006-09-30Completed
Morphine Versus Methadone for Opiate Exposed Infants With Neonatal Abstinence Syndrome[NCT02851303]Phase 461 participants (Actual)Interventional2016-10-31Completed
Improving Outcomes in Neonatal Abstinence Syndrome[NCT01958476]Phase 3117 participants (Actual)Interventional2013-09-30Completed
Treating the Partners of Drug Using Pregnant Women: Stage II[NCT00496990]Phase 2/Phase 3158 participants (Actual)Interventional2005-10-31Completed
Fetal Neurobehavior in Non-methadone Maintained Women in Substance Abuse Treatment[NCT00522626]19 participants (Actual)Observational2006-08-31Completed
Methadone, Buprenorphine and Fetal Neurobehavior[NCT00653692]29 participants (Actual)Observational2007-05-31Completed
A Prospective Observational Clinical Trial to Compare the Effect of Immediate Postpartum Nexplanon Placement Versus Standard Postpartum Contraceptive Care on Consistent Contraceptive Use and Rapid Repeat Pregnancy in Opioid Dependent Women.[NCT02657148]200 participants (Actual)Observational2016-05-31Completed
Safety, Efficacy, Pharmacokinetics, and Pharmacogenomics of Extended-Release Naltrexone in Pregnant Women[NCT03718104]100 participants (Anticipated)Observational2018-12-01Recruiting
Single-dose Intraoperative Methadone for Early Ambulation and Sustained Pain Control in Spinal Fusion Surgery Patients[NCT02989597]Phase 410 participants (Actual)Interventional2017-07-29Terminated (stopped due to Due to personnel loss and logistical issues the study was unable to be completed as planned.)
The Effects of Opioid Taper on Opioid-Induced Hyperalgesia[NCT03063905]15 participants (Actual)Observational2017-01-31Terminated (stopped due to funding expired)
Effect of Continuous Positive Airway Pressure on Fetal pH at Time of Scheduled Cesarean Delivery in Morbidly Obese Women[NCT04993651]80 participants (Anticipated)Interventional2021-10-11Recruiting
Methadone, Buprenorphine and Fetal Development[NCT00067184]157 participants (Actual)Observational2002-09-30Completed
Influence of Aging on Perioperative Methadone Dosing[NCT04526236]Phase 460 participants (Actual)Interventional2019-09-03Completed
Breastfeeding Among Methadone Maintained Women[NCT00218010]25 participants (Actual)Observational2000-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Child's Head Circumference Measurement (Measured at Birth)

(NCT00271219)
Timeframe: birth

Interventioncm (Mean)
A Methadone33.0
B Buprenorphine33.8

Child's Length of Hospital Stay

(NCT00271219)
Timeframe: delivery until hospital discharge (min=2 days, max=79 days)

Interventiondays (Mean)
A Methadone17.5
B Buprenorphine10.0

Child's Peak Daily Total NAS Score

NAS was measured with the MOTHER NAS scale, which includes 28 items, 19 of which are used for scoring and medication decisions. Scores can range from 0 to 42, with higher scores indicating more severe withdrawal. (NCT00271219)
Timeframe: minimum twice daily from birth until NAS no longer measured (min=10 days)

InterventionScore on the scale (Mean)
A Methadone12.8
B Buprenorphine11.0

Mother's HIV Risk Behaviors (Measured Monthly by Risk Behavior Assessment)

(NCT00271219)
Timeframe: monthly from study entry until discontinuation or delivery (min=29 days, max=239 days)

Interventionpercentage of HIV risk behaviors (Number)
A MethadoneNA
B BuprenorphineNA

Mother's Measures of Dose Adequacy and Acceptance Over Time (Measured Weekly by Dose Adequacy Measure)

Pregnant women maintained on an opioid agonist medication may require upward adjustment to their medication during the course of pregnant. The Dose Adequacy Measure represented a recordation of dosing adjustments during the course of the study. (NCT00271219)
Timeframe: from study entry until discontinuation or delivery (min=29 days, max=239 days)

Interventiondose increase per trimester (Number)
A MethadoneNA
B BuprenorphineNA

Mother's Psychosocial Functioning at Delivery as Measured by the Addiction Severity Index Psychosocial Index Score

The Addiction Severity Index is a structured clinical interview that assesses problem severity in 7 areas of functioning: alcohol use, drug use, medical, legal, employment, psychosocial, and psychiatric status. Each area of functioning yields a composite scale score between 0 and 1, with higher scores indicating greater problem severity in that area. Only the psychosocial index was examined in this study. (NCT00271219)
Timeframe: at delivery

InterventionScore on the scale (Mean)
Methadone.014
Buprenorphine.088

Mother's Self-report of Drug Use (Measured Monthly by Time Line Follow Back)

(NCT00271219)
Timeframe: monthly from study entry until discontinuation or delivery (min=29 days, max=239 days)

Interventionpercentage of drug use (Number)
A MethadoneNA
B BuprenorphineNA

Number of Children Requiring Treatment for Neonatal Abstinence Signs (NAS)

Neonatal abstinence syndrome (NAS) characterized by hyperirritability of the central nervous system and dysfunction in the autonomic nervous system, gastrointestinal tract, and respiratory system.11 When left untreated, NAS can result in serious illness (e.g., diarrhea, feeding difficulties, weight loss, and seizures) and death. (NCT00271219)
Timeframe: From birth until hospital discharge (min=4 days, max=10, depending on site)

Interventionparticipants (Number)
A Methadone41
B Buprenorphine27

Total Amount of Morphine Sulfate That a Neonate Receives to Treat NAS

Total amount in mg (NCT00271219)
Timeframe: Start of NAS treatment until discontinuation of NAS treatment (min=0 days, max=76 days)

Interventionmg (Mean)
A Methadone10.4
B Buprenorphine1.1

Breastfeeding Initiation and Continuation at Hospital Discharge

Assessed through chart review of discharge summary documentation of method of infant feeding at time of discharge (NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days

InterventionParticipants (Count of Participants)
Morphine5
Methadone5

Length of Hospital Stay

Number of days in hospital after birth (NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days

Interventiondays (Mean)
Morphine17.9
Methadone16.1

Length of Treatment

(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days

Interventiondays (Mean)
Morphine14.7
Methadone12.8

Need for Additional Agent to Treat Withdrawal, Determined by Chart Review of Medication Administration Record of Administered Medications for Withdrawal Treatment (Example: Clonidine or Phenobarbital)

clonidine (NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days

InterventionParticipants (Count of Participants)
Morphine1
Methadone0

Need for Feeding Assistance, Determined by Chart Review of Discharge Summary, Specifically Evaluating for Need for Nasogastric Tube Placement or Peripheral Parenteral Nutrition.

(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days

InterventionParticipants (Count of Participants)
Morphine11
Methadone6

Need for NICU Transfer, as Determined by Chart Review of Discharge Summary.

(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days

InterventionParticipants (Count of Participants)
Morphine0
Methadone3

Total Morphine Equivalent Dose Received

(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days

Interventionmorphine equivalents mg (Mean)
Morphine9.86
Methadone33.0

Growth Outcome: Head Circumference at 18 Months

Average head circumference growth outcome at 18 month follow-up visit. (NCT01958476)
Timeframe: 18 month follow-up visit

Interventioncm (Mean)
Methadone47.8
Neonatal Morphine Solution48.2

Growth Outcome: Length at 18 Months

Average length (cm) at 18 month follow-up visit. (NCT01958476)
Timeframe: 18 month follow-up visit

Interventioncm (Mean)
Methadone82.1
Neonatal Morphine Solution81.7

Growth Outcome: Weight Change From Birth to 18 Months

Growth outcome weight (lbs) depicted as difference in averaged weights from birth to 18 month follow-up visit. Standard deviations were averaged between birth and 18 mo time points. (NCT01958476)
Timeframe: Birth to 18 month follow-up visit

Interventionlbs (Mean)
Methadone19.1
Neonatal Morphine Solution18.7

Length of Hospital Stay (LOS)

Participants were monitored for the duration of their hospitalization, an expected mean of 22 days. (NCT01958476)
Timeframe: Participants will be monitored during their entire hospitalization, expected mean 22 days.

Interventiondays (Mean)
Methadone21.8
Neonatal Morphine Solution23.2

Length of Hospital Stay (LOS) Due to Neonatal Abstinence Syndrome (NAS)

Participants were monitored for the duration of their hospitalization attributable to NAS only. (NCT01958476)
Timeframe: Participants were monitored for the duration of their hospitalization, expected mean 22 days.

Interventiondays (Mean)
Methadone18.9
Neonatal Morphine Solution21.1

Length of Treatment (LOT)

Total number of days infant treated with replacement opioids while admitted to the hospital. (NCT01958476)
Timeframe: Participants were monitored for the duration of their hospitalization.

Interventiondays (Mean)
Methadone14.7
Neonatal Morphine Solution16.6

Number of Infants Needing a Dose Increase

"One Finnegan score ≥12, or two consecutive scores ≥8 affirms the requirement for pharmacological treatment or increasing treatment dosage. If the infant continued to have two consecutive Finnegan Scores ≥8 two times consecutively, or one ≥12, the dose was increased to the next level. (Level I: 0.3 mg/kg/day) (Level II: 0.5 mg/kg/day) (Level III: 0.7 mg/kg/day)~A higher Finnegan score indicates greater severity of NAS (min 0, max 50)." (NCT01958476)
Timeframe: Participants were monitored for the duration of their hospitalization, an average of 22 days.

InterventionParticipants (Count of Participants)
Methadone22
Neonatal Morphine Solution28

Number of Infants Needing a Second NAS Medication

Number of infants treated with a second medication following protocol, phenobarbital. If the Finnegan Score remained elevated (still scored ≥8 two times consecutively, or still scored once ≥12) despite increasing to a predetermined maximal opioid dose (methadone or morphine), phenobarbital was administered (20-mg/kg loading dose followed by 4-5 mg/kg daily). (NCT01958476)
Timeframe: Participants were monitored for the duration of their hospitalization, an average of 22 days.

InterventionParticipants (Count of Participants)
Methadone10
Neonatal Morphine Solution17

Cognitive, Language, and Motor Development From 18 Month Bayley III Neurodevelopmental Assessment

The Bayley Scales of Infant and Toddler Development (BSID-III) assesses the development of infants and children (1-42 months) through a series of developmental play tasks, identifying children with developmental delay. Raw scores of completed items are summarized within three distinct scale scores (Cognitive Scale, Language Scale, Motor Scale). Scale scores are each converted to composite scores to determine the child's performance compared with scores of age-matched children of typical development (percentile rank). A higher composite score indicates more ideal developmental outcome (range 40-160). At 18 month follow-up visit, participants were assessed using the BSID-III for cognitive, language and motor scale composite score outcomes. (NCT01958476)
Timeframe: Assessment at 18 month follow-up visit

,
Interventionscores on a scale (Composite) (Mean)
Cognitive CompositeLanguage CompositeMotor Composite
Methadone100.196.0103.6
Neonatal Morphine Solution98.194.299.1

Fetal Heart Rate

Fetal heart rate in beats per minute (NCT00522626)
Timeframe: 60 minutes

Interventionbeats per minute (Mean)
Trough Fetal Heart Rate142.34

Reviews

133 reviews available for methadone and Pregnancy

ArticleYear
Opioid treatment programs, telemedicine and COVID-19: A scoping review.
    Substance abuse, 2022, Volume: 43, Issue:1

    Topics: Analgesics, Opioid; Buprenorphine; COVID-19 Drug Treatment; Female; Humans; Methadone; Opiate Substi

2022
Neonatal opioid withdrawal syndrome: a review of the science and a look toward the use of buprenorphine for affected infants.
    Journal of perinatology : official journal of the California Perinatal Association, 2022, Volume: 42, Issue:3

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant; Infant, Newborn; Methadone; Neonatal Abst

2022
Ophthalmic outcomes in children exposed to opioid maintenance treatment in utero: A systematic review and meta-analysis.
    Neuroscience and biobehavioral reviews, 2022, Volume: 136

    Topics: Analgesics, Opioid; Buprenorphine; Child; Female; Humans; Infant; Methadone; Opiate Substitution Tre

2022
SIDS is associated with prenatal drug use: a meta-analysis and systematic review of 4 238 685 infants.
    Archives of disease in childhood. Fetal and neonatal edition, 2022, Volume: 107, Issue:6

    Topics: Analgesics, Opioid; Cocaine; Female; Humans; Infant; Methadone; Observational Studies as Topic; Preg

2022
Buprenorphine Compared with Methadone in Pregnancy: A Systematic Review and Meta-Analysis.
    Substance use & misuse, 2022, Volume: 57, Issue:9

    Topics: Analgesics, Opioid; Buprenorphine; Child; Female; Humans; Infant, Newborn; Methadone; Opiate Substit

2022
Opioid Use Disorder in Pregnant Patients.
    Anesthesia and analgesia, 2022, 11-01, Volume: 135, Issue:5

    Topics: Analgesics, Opioid; Anesthetics; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treat

2022
Prenatal Opioid Exposure and Neurodevelopmental Outcomes.
    Journal of neurosurgical anesthesiology, 2023, Jan-01, Volume: 35, Issue:1

    Topics: Analgesics, Opioid; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Methadone; Neonatal A

2023
Opioids and Opioid Use Disorder in Pregnancy.
    Obstetrics and gynecology clinics of North America, 2023, Volume: 50, Issue:1

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-

2023
Harmful effects of opioid use in pregnancy: A scientific review commissioned by the European Board and College of obstetrics and gynaecology (EBCOG).
    European journal of obstetrics, gynecology, and reproductive biology, 2023, Volume: 286

    Topics: Analgesics, Opioid; Buprenorphine; Female; Gynecology; Humans; Infant; Methadone; Obstetrics; Opiate

2023
Monitoring Prenatal Exposure to Buprenorphine and Methadone.
    Therapeutic drug monitoring, 2020, Volume: 42, Issue:2

    Topics: Analgesics, Opioid; Buprenorphine; Drug Monitoring; Female; Hair; Humans; Meconium; Methadone; Opiat

2020
Opioid Use Disorder: Medical Treatment Options.
    American family physician, 2019, 10-01, Volume: 100, Issue:7

    Topics: Analgesics, Opioid; Buprenorphine; Chronic Disease; Evidence-Based Medicine; Female; Humans; Male; M

2019
Neonatal Abstinence Syndrome: Review of Epidemiology, Care Models, and Current Understanding of Outcomes.
    Clinics in perinatology, 2019, Volume: 46, Issue:4

    Topics: Analgesics, Opioid; Breast Feeding; Buprenorphine; Female; Humans; Hypnotics and Sedatives; Infant,

2019
Opioid Use in Pregnancy.
    Current psychiatry reports, 2019, 11-16, Volume: 21, Issue:12

    Topics: Buprenorphine; Child Development; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Sy

2019
Prenatal exposure to methadone or buprenorphine and long-term outcomes: A meta-analysis.
    Early human development, 2020, Volume: 143

    Topics: Analgesics, Opioid; Animals; Buprenorphine; Child; Female; Humans; Infant, Newborn; Male; Methadone;

2020
Cognitive Outcomes of Young Children After Prenatal Exposure to Medications for Opioid Use Disorder: A Systematic Review and Meta-analysis.
    JAMA network open, 2020, 03-02, Volume: 3, Issue:3

    Topics: Analgesics, Opioid; Buprenorphine; Child Development; Child, Preschool; Cognition; Cognitive Dysfunc

2020
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
Opioid Management in Pregnancy and Postpartum.
    Obstetrics and gynecology clinics of North America, 2020, Volume: 47, Issue:3

    Topics: Adult; Analgesics, Opioid; Buprenorphine; Cesarean Section; Female; Humans; Infant, Newborn; Labor,

2020
Changing Outdated Methadone Regulations That Harm Pregnant Patients.
    Journal of addiction medicine, 2021, 04-01, Volume: 15, Issue:2

    Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Health Policy; Humans; Methadone; Opia

2021
Maintenance agonist treatments for opiate-dependent pregnant women.
    The Cochrane database of systematic reviews, 2020, 11-09, Volume: 11

    Topics: Birth Weight; Buprenorphine; Delayed-Action Preparations; Female; Humans; Infant; Infant, Newborn; M

2020
Use of Medications for Treatment of Opioid Use Disorder Among US Medicaid Enrollees in 11 States, 2014-2018.
    JAMA, 2021, 07-13, Volume: 326, Issue:2

    Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Child; Cross-Sectional Studies; Female; Humans

2021
Peripartum Anesthetic Management of the Opioid-tolerant or Buprenorphine/Suboxone-dependent Patient.
    Clinical obstetrics and gynecology, 2017, Volume: 60, Issue:2

    Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Female; Humans; Methado

2017
Neonatal Abstinence Syndrome: Update on Diagnostic and Therapeutic Strategies.
    Pharmacotherapy, 2017, Volume: 37, Issue:7

    Topics: Analgesics, Opioid; Antidepressive Agents; Buprenorphine; Female; Humans; Infant, Newborn; Methadone

2017
A Retrospective Cohort Study of Obstetric Outcomes in Opioid-Dependent Women Treated with Implant Naltrexone, Oral Methadone or Sublingual Buprenorphine, and Non-Dependent Controls.
    Drugs, 2017, Volume: 77, Issue:11

    Topics: Administration, Oral; Administration, Sublingual; Buprenorphine; Drug Implants; Female; Humans; Meth

2017
Methadone, Buprenorphine, and Naltrexone for the Treatment of Opioid Use Disorder in Pregnant Women.
    Pharmacotherapy, 2017, Volume: 37, Issue:7

    Topics: Analgesics, Opioid; Animals; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naltrexone;

2017
Maternal Use of Opioids During Pregnancy and Congenital Malformations: A Systematic Review.
    Pediatrics, 2017, Volume: 139, Issue:6

    Topics: Abnormalities, Drug-Induced; Analgesics, Opioid; Female; Humans; Methadone; Morphine Derivatives; Op

2017
Treatment of Perinatal Opioid Use Disorder.
    Obstetrics and gynecology clinics of North America, 2018, Volume: 45, Issue:3

    Topics: Adult; Analgesics, Opioid; Decision Making; Female; Humans; Infant, Newborn; Methadone; Neonatal Abs

2018
Opioid Detoxification in Pregnancy: Systematic Review and Meta-Analysis of Perinatal Outcomes.
    American journal of perinatology, 2019, Volume: 36, Issue:6

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence S

2019
Neonatal abstinence syndrome.
    Nature reviews. Disease primers, 2018, 11-22, Volume: 4, Issue:1

    Topics: Adult; Female; Humans; Infant; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Opiate Subs

2018
Childhood neurodevelopment after prescription of maintenance methadone for opioid dependency in pregnancy: a systematic review and meta-analysis.
    Developmental medicine and child neurology, 2019, Volume: 61, Issue:7

    Topics: Child; Child Development; Child, Preschool; Female; Humans; Infant; Methadone; Narcotics; Opioid-Rel

2019
Morphine and Methadone for Neonatal Abstinence Syndrome: A Systematic Review.
    Neonatal network : NN, 2018, Volume: 37, Issue:6

    Topics: Analgesics, Opioid; Female; Humans; Infant; Infant, Newborn; Length of Stay; Male; Methadone; Morphi

2018
Opioid use disorder during pregnancy: An overview.
    JAAPA : official journal of the American Academy of Physician Assistants, 2019, Volume: 32, Issue:3

    Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Cognitive Behavioral Therapy; Female; Fetal Di

2019
Pharmacological treatment of opioid use disorder in pregnancy.
    Seminars in perinatology, 2019, Volume: 43, Issue:3

    Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Guidelines as Topic; Humans; Methadone; Narcotic A

2019
Post-cesarean delivery pain. Management of the opioid-dependent patient before, during and after cesarean delivery.
    International journal of obstetric anesthesia, 2019, Volume: 39

    Topics: Analgesia, Patient-Controlled; Buprenorphine; Cesarean Section; Female; Humans; Methadone; Naltrexon

2019
Analgesia, Opioids, and Other Drug Use During Pregnancy and Neonatal Abstinence Syndrome.
    Clinics in perinatology, 2019, Volume: 46, Issue:2

    Topics: Analgesia, Obstetrical; Analgesics; Analgesics, Opioid; Breast Feeding; Buprenorphine; Buprenorphine

2019
Management and monitoring of opioid use in pregnancy.
    Acta obstetricia et gynecologica Scandinavica, 2020, Volume: 99, Issue:1

    Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Maternal-Fetal Exchange; Methadone; Narcot

2020
Consideration of opioid agonist treatment in a pregnant adolescent: A case report and literature review.
    Substance abuse, 2020, Volume: 41, Issue:2

    Topics: Adolescent; Ambulatory Care; Analgesics, Opioid; Buprenorphine; Child, Foster; Female; Humans; Lost

2020
Chronic opioid use during pregnancy: maternal and fetal implications.
    Clinics in perinatology, 2013, Volume: 40, Issue:3

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence S

2013
Managing opioid dependence in pregnancy -- a general practice perspective.
    Australian family physician, 2013, Volume: 42, Issue:10

    Topics: Adult; Buprenorphine; Female; General Practice; Humans; Methadone; Narcotics; Neonatal Abstinence Sy

2013
Medication-assisted treatment with methadone: assessing the evidence.
    Psychiatric services (Washington, D.C.), 2014, Feb-01, Volume: 65, Issue:2

    Topics: Analgesics, Opioid; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorde

2014
Maintenance agonist treatments for opiate-dependent pregnant women.
    The Cochrane database of systematic reviews, 2013, Dec-23, Issue:12

    Topics: Birth Weight; Buprenorphine; Delayed-Action Preparations; Female; Humans; Infant; Infant, Newborn; M

2013
Behavioral effects of perinatal opioid exposure.
    Life sciences, 2014, May-28, Volume: 104, Issue:1-2

    Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Female; Humans; Illicit Drugs; Infant, Ne

2014
Buprenorphine and methadone for opioid addiction during pregnancy.
    Obstetrics and gynecology clinics of North America, 2014, Volume: 41, Issue:2

    Topics: Analgesics, Opioid; Buprenorphine; Drug Administration Schedule; Female; Humans; Methadone; Neonatal

2014
Neonatal opioid withdrawal syndrome.
    Obstetrics and gynecology clinics of North America, 2014, Volume: 41, Issue:2

    Topics: Analgesics, Opioid; Breast Feeding; Buprenorphine; Female; Humans; Infant, Newborn; Male; Methadone;

2014
Neonatal abstinence syndrome.
    Pediatrics, 2014, Volume: 134, Issue:2

    Topics: Animals; Breast Feeding; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; O

2014
Prenatal buprenorphine versus methadone exposure and neonatal outcomes: systematic review and meta-analysis.
    American journal of epidemiology, 2014, Oct-01, Volume: 180, Issue:7

    Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Models, Statistical; Neonatal Abstinence

2014
Review of the assessment and management of neonatal abstinence syndrome.
    Addiction science & clinical practice, 2014, Sep-09, Volume: 9, Issue:1

    Topics: Breast Feeding; Buprenorphine; Clonidine; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neo

2014
Treating tobacco use disorder in pregnant women in medication-assisted treatment for an opioid use disorder: a systematic review.
    Journal of substance abuse treatment, 2015, Volume: 52

    Topics: Analgesics, Opioid; Behavior Therapy; Buprenorphine; Female; Humans; Methadone; Opiate Substitution

2015
Medication assisted treatment discontinuation in pregnant and postpartum women with opioid use disorder.
    Drug and alcohol dependence, 2015, Apr-01, Volume: 149

    Topics: Buprenorphine; Female; Humans; Kaplan-Meier Estimate; Methadone; Narcotic Antagonists; Narcotics; Op

2015
Question: is breastfeeding useful in the management of neonatal abstinence syndrome?
    Archives of disease in childhood, 2015, Volume: 100, Issue:4

    Topics: Breast Feeding; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinence Syndrome;

2015
Pharmacological Management of Opioid Use Disorder in Pregnant Women.
    CNS drugs, 2015, Volume: 29, Issue:8

    Topics: Analgesics, Opioid; Animals; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Opiate Subst

2015
New Pain Management Options for the Surgical Patient on Methadone and Buprenorphine.
    Current pain and headache reports, 2016, Volume: 20, Issue:3

    Topics: Buprenorphine; Drug Administration Schedule; Female; Humans; Methadone; Neonatal Abstinence Syndrome

2016
Buprenorphine Versus Methadone for Opioid Dependence in Pregnancy.
    The Annals of pharmacotherapy, 2016, Volume: 50, Issue:8

    Topics: Buprenorphine; Female; Humans; Infant; Infant, Newborn; Length of Stay; Methadone; Neonatal Abstinen

2016
Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child.
    Addiction (Abingdon, England), 2016, Volume: 111, Issue:12

    Topics: Abnormalities, Drug-Induced; Analgesics, Opioid; Birth Weight; Buprenorphine; Female; Fetal Death; F

2016
Long-Term Outcomes of Infants with Neonatal Abstinence Syndrome.
    Neonatal network : NN, 2016, Volume: 35, Issue:5

    Topics: Analgesics, Opioid; Child Abuse; Epigenesis, Genetic; Female; Humans; Infant, Newborn; Methadone; Ne

2016
Opioid dependence and pregnancy: minimizing stress on the fetal brain.
    American journal of obstetrics and gynecology, 2017, Volume: 216, Issue:3

    Topics: Brain Diseases; Buprenorphine; Female; Fetal Diseases; Humans; Methadone; Opioid-Related Disorders;

2017
Neonatal Abstinence Syndrome.
    The New England journal of medicine, 2016, 12-22, Volume: 375, Issue:25

    Topics: Female; Humans; Incidence; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome; Opiat

2016
Pregnancy and injecting drug use.
    BMJ (Clinical research ed.), 2008, Jun-07, Volume: 336, Issue:7656

    Topics: Female; Humans; Methadone; Narcotics; Opioid-Related Disorders; Patient Care Planning; Pregnancy; Pr

2008
Treating pregnant women dependent on opioids is not the same as treating pregnancy and opioid dependence: a knowledge synthesis for better treatment for women and neonates.
    Addiction (Abingdon, England), 2008, Volume: 103, Issue:9

    Topics: Buprenorphine; Diagnosis, Dual (Psychiatry); Female; GABA Modulators; Humans; Infant, Newborn; Menta

2008
Methadone exposure during lactation.
    Canadian family physician Medecin de famille canadien, 2008, Volume: 54, Issue:12

    Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Humans; Lactation; Maternal Exposure;

2008
[Methadone treatment and its dangers].
    Medicina (Kaunas, Lithuania), 2009, Volume: 45, Issue:5

    Topics: Adult; Analgesics, Opioid; Child, Preschool; Drug Interactions; Drug Overdose; Electrocardiography;

2009
[Utility of atazanavir in special populations].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 17

    Topics: Adolescent; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Cardi

2008
Prenatal drug exposure: infant and toddler outcomes.
    Journal of addictive diseases, 2010, Volume: 29, Issue:2

    Topics: Buprenorphine; Child Development; Child, Preschool; Cocaine; Cocaine-Related Disorders; Female; Hero

2010
The management of heroin misuse in pregnancy: time for a rethink?
    Archives of disease in childhood. Fetal and neonatal edition, 2011, Volume: 96, Issue:6

    Topics: Buprenorphine; Child, Preschool; Developmental Disabilities; Female; Heroin Dependence; Humans; Infa

2011
Methadone dose and neonatal abstinence syndrome-systematic review and meta-analysis.
    Addiction (Abingdon, England), 2010, Volume: 105, Issue:12

    Topics: Cohort Studies; Databases, Bibliographic; Dose-Response Relationship, Drug; Female; Humans; Infant,

2010
Drug interactions associated with methadone, buprenorphine, cocaine, and HIV medications: implications for pregnant women.
    Life sciences, 2011, May-23, Volume: 88, Issue:21-22

    Topics: Anti-HIV Agents; Buprenorphine; Cocaine; Drug Interactions; Female; HIV Infections; Humans; Methadon

2011
Prenatal exposure to methadone and buprenorphine: a review of the potential effects on cognitive development.
    Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence, 2011, Volume: 17, Issue:5

    Topics: Analgesics, Opioid; Buprenorphine; Child; Child Development; Cognition; Female; Humans; Male; Methad

2011
Intrauterine abstinence syndrome (IAS) during buprenorphine inductions and methadone tapers: can we assure the safety of the fetus?
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2012, Volume: 25, Issue:2

    Topics: Buprenorphine; Epigenesis, Genetic; Female; Fetal Diseases; Humans; Methadone; Narcotics; Pregnancy;

2012
Update on the pharmacologic management of neonatal abstinence syndrome.
    Journal of perinatology : official journal of the California Perinatal Association, 2011, Volume: 31, Issue:11

    Topics: Benzodiazepines; Buprenorphine; Clonidine; Female; Humans; Hypnotics and Sedatives; Infant, Newborn;

2011
[Breast feeding during methadon- and buprenorphin therapy].
    Klinische Padiatrie, 2011, Volume: 223, Issue:7

    Topics: Analgesics, Opioid; Breast Feeding; Buprenorphine; Contraindications; Dose-Response Relationship, Dr

2011
[Pregnant opioid addicted patients and additional drug intake. Part I. Toxic effects and therapeutic consequences].
    Medizinische Monatsschrift fur Pharmazeuten, 2011, Volume: 34, Issue:10

    Topics: Adult; Alcoholism; Central Nervous System Stimulants; Drug Monitoring; Female; Heroin Dependence; Hu

2011
Management of opioid substitution therapy during medical intervention.
    Internal medicine journal, 2012, Volume: 42, Issue:3

    Topics: Analgesics; Australia; Buprenorphine; Comorbidity; Drug Interactions; Female; Humans; Liver Diseases

2012
Naltrexone in the treatment of opioid-dependent pregnant women: the case for a considered and measured approach to research.
    Addiction (Abingdon, England), 2013, Volume: 108, Issue:2

    Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naltrexone; Narcotic Antagonists; Narcoti

2013
Methadone and buprenorphine for the management of opioid dependence in pregnancy.
    Drugs, 2012, Apr-16, Volume: 72, Issue:6

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence S

2012
Novel pharmacotherapeutic strategies for treatment of opioid-induced neonatal abstinence syndrome.
    Seminars in fetal & neonatal medicine, 2013, Volume: 18, Issue:1

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Immunotherapy; Infant, Newborn; Methadone; Neonat

2013
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone;

2012
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone;

2012
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone;

2012
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone;

2012
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone;

2012
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone;

2012
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone;

2012
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone;

2012
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone;

2012
Neonatal abstinence syndrome: therapeutic interventions.
    MCN. The American journal of maternal child nursing, 2013, Volume: 38, Issue:2

    Topics: Female; Humans; Infant; Infant Welfare; Infant, Newborn; Male; Methadone; Morphine; Narcotics; Neona

2013
Opioid addiction in pregnancy.
    Obstetrical & gynecological survey, 2012, Volume: 67, Issue:12

    Topics: Analgesics, Opioid; Breast Feeding; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neona

2012
Pharmacologic management of neonatal abstinence syndrome in a community hospital.
    Clinical obstetrics and gynecology, 2013, Volume: 56, Issue:1

    Topics: Analgesics, Opioid; Female; Florida; Humans; Infant, Newborn; Intensive Care, Neonatal; Length of St

2013
Neonatal abstinence syndrome: treatment and pediatric outcomes.
    Clinical obstetrics and gynecology, 2013, Volume: 56, Issue:1

    Topics: Developmental Disabilities; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinen

2013
The effect of abused substances on antenatal and intrapartum fetal testing and well-being.
    Clinical obstetrics and gynecology, 2013, Volume: 56, Issue:1

    Topics: Alcohol Drinking; Biophysical Phenomena; Blood Flow Velocity; Cocaine; Female; Fetal Movement; Heart

2013
Chronic and acute pain and pain management for patients in methadone maintenance treatment.
    The American journal on addictions, 2013, Volume: 22, Issue:1

    Topics: Acute Pain; Analgesics; Catastrophization; Chronic Pain; Drug Tolerance; Female; Humans; Methadone;

2013
[Is buprenorphine a potential alternative to methadone for treating pregnant drug users? Inventory of clinical data in the literature].
    Annales de medecine interne, 2002, Volume: 153, Issue:7 Suppl

    Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Narcotic Antagonists; Narcotics; Neonatal

2002
Pharmacotherapy for pregnant women with addictions.
    American journal of obstetrics and gynecology, 2004, Volume: 191, Issue:6

    Topics: Adolescent; Adult; Behavior, Addictive; Cocaine-Related Disorders; Female; Follow-Up Studies; Gestat

2004
[Therapeutic strategies for opioid addiction: the role of substitution therapy].
    Presse medicale (Paris, France : 1983), 2004, Oct-23, Volume: 33, Issue:18 Suppl

    Topics: Buprenorphine; Female; Humans; Mental Disorders; Methadone; Narcotic Antagonists; Narcotics; Opioid-

2004
Pharmacokinetics of methadone.
    Journal of pain & palliative care pharmacotherapy, 2005, Volume: 19, Issue:4

    Topics: Aged; Analgesics, Opioid; Area Under Curve; Biological Availability; Child; Cytochrome P-450 Enzyme

2005
Pharmacokinetics of methadone.
    Journal of pain & palliative care pharmacotherapy, 2005, Volume: 19, Issue:4

    Topics: Aged; Analgesics, Opioid; Area Under Curve; Biological Availability; Child; Cytochrome P-450 Enzyme

2005
Pharmacokinetics of methadone.
    Journal of pain & palliative care pharmacotherapy, 2005, Volume: 19, Issue:4

    Topics: Aged; Analgesics, Opioid; Area Under Curve; Biological Availability; Child; Cytochrome P-450 Enzyme

2005
Pharmacokinetics of methadone.
    Journal of pain & palliative care pharmacotherapy, 2005, Volume: 19, Issue:4

    Topics: Aged; Analgesics, Opioid; Area Under Curve; Biological Availability; Child; Cytochrome P-450 Enzyme

2005
Methadone and buprenorphine treatment during pregnancy: what are the effects on infants?
    Nursing for women's health, 2007, Volume: 11, Issue:6

    Topics: Analgesics, Opioid; Buprenorphine; Female; Fetus; Humans; Infant, Low Birth Weight; Infant, Newborn;

2007
Treatment of opioid-dependent pregnant women: clinical and research issues.
    Journal of substance abuse treatment, 2008, Volume: 35, Issue:3

    Topics: Analgesics, Opioid; Buprenorphine; Clinical Trials as Topic; Decision Making; Female; Humans; Infant

2008
Opioid dependence and pregnancy.
    Current opinion in psychiatry, 2008, Volume: 21, Issue:3

    Topics: Buprenorphine; Female; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy

2008
Maintenance agonist treatments for opiate dependent pregnant women.
    The Cochrane database of systematic reviews, 2008, Apr-16, Issue:2

    Topics: Birth Weight; Buprenorphine; Female; Humans; Infant; Infant, Newborn; Methadone; Narcotics; Opioid-R

2008
Effects of perinatal exposure to methadone on development of neurotransmission: biochemical bases for behavioral alterations.
    Monographs in neural sciences, 1983, Volume: 9

    Topics: Animals; Behavior, Animal; Brain; Female; Methadone; Nervous System; Neurotransmitter Agents; Norepi

1983
Behavioral effects of prenatal exposure to opiates.
    Monographs in neural sciences, 1983, Volume: 9

    Topics: Age Factors; Animals; Animals, Suckling; Behavior, Animal; Female; Heroin; Humans; Methadone; Mice;

1983
Infants of drug-dependent mothers.
    Seminars in roentgenology, 1983, Volume: 18, Issue:3

    Topics: Abnormalities, Drug-Induced; Female; Fetal Alcohol Spectrum Disorders; Fetal Growth Retardation; Her

1983
Rifampin drug interactions.
    Archives of internal medicine, 1984, Volume: 144, Issue:8

    Topics: Anticoagulants; Barbiturates; Contraceptives, Oral; Cytochrome P-450 Enzyme System; Digitoxin; Drug

1984
Male mediated drug effects on offspring.
    Progress in clinical and biological research, 1980, Volume: 36

    Topics: Animals; Birth Weight; Fathers; Female; Humans; Litter Size; Male; Methadone; Morphine; Pregnancy; R

1980
The consequences of prenatal substance use for the developing fetus, newborn, and young child.
    The International journal of the addictions, 1993, Volume: 28, Issue:13

    Topics: Cannabis; Child; Child, Preschool; Congenital Abnormalities; Developmental Disabilities; Female; Hea

1993
Effects of in-utero opiate exposure: new paradigms for old questions.
    Drug and alcohol dependence, 1994, Volume: 36, Issue:2

    Topics: Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related

1994
A new look at some old mechanisms in human newborns: taste and tactile determinants of state, affect, and action.
    Monographs of the Society for Research in Child Development, 1994, Volume: 59, Issue:1

    Topics: Affect; Crying; Female; Heart Rate; Humans; Infant Care; Infant, Newborn; Male; Methadone; Mother-Ch

1994
Bridging species: a new look and new questions.
    Monographs of the Society for Research in Child Development, 1994, Volume: 59, Issue:1

    Topics: Female; Humans; Infant Care; Infant, Newborn; Male; Methadone; Mother-Child Relations; Mothers; Preg

1994
Methadone during pregnancy: the search for a valid animal model.
    Annali dell'Istituto superiore di sanita, 1993, Volume: 29, Issue:3

    Topics: Animals; Behavior, Animal; Child; Child, Preschool; Disease Models, Animal; Female; Heroin Dependenc

1993
Prenatal diagnosis of amniotic band syndrome in a methadone user: review of the literature and a case report.
    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 1996, Volume: 8, Issue:2

    Topics: Adult; Amniotic Band Syndrome; Female; Fetal Diseases; Forearm; Gestational Age; Humans; Infant, New

1996
Pharmacotherapy for opioid and cocaine abuse.
    The Medical clinics of North America, 1997, Volume: 81, Issue:4

    Topics: Antidepressive Agents; Cocaine; Dopamine Agonists; Female; Humans; Methadone; Narcotic Antagonists;

1997
Helping patients who misuse drugs.
    Drug and therapeutics bulletin, 1997, Volume: 35, Issue:3

    Topics: Central Nervous System Depressants; Family Practice; Female; Humans; Methadone; Narcotics; Opioid-Re

1997
The relationship between maternal use of heroin and methadone and infant birth weight.
    Addiction (Abingdon, England), 1997, Volume: 92, Issue:11

    Topics: Birth Weight; Female; Heroin; Humans; Infant, Low Birth Weight; Infant, Newborn; Methadone; Opioid-R

1997
Opioid dependence during pregnancy. Effects and management.
    Obstetrics and gynecology clinics of North America, 1998, Volume: 25, Issue:1

    Topics: Delivery, Obstetric; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinence Synd

1998
Assessing the relationship between maternal opiate use and neonatal mortality.
    Addiction (Abingdon, England), 1998, Volume: 93, Issue:7

    Topics: Female; Heroin; Humans; Infant Mortality; Infant, Newborn; Methadone; Narcotics; Opioid-Related Diso

1998
Neonatal drug addiction.
    Panminerva medica, 1998, Volume: 40, Issue:3

    Topics: Female; Heroin; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinence Syndrome; Pregnan

1998
Methadone in the management of narcotic addiction in pregnancy.
    Current opinion in obstetrics & gynecology, 1998, Volume: 10, Issue:6

    Topics: Female; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy; Pregnancy Complications

1998
[Substitution therapy of drug addicts].
    Presse medicale (Paris, France : 1983), 1998, Dec-12, Volume: 27, Issue:39

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Pregnancy; Pregnancy Complications; Pr

1998
Early development of infants exposed to drugs prenatally.
    Clinics in perinatology, 1999, Volume: 26, Issue:1

    Topics: Alcoholism; Child Abuse; Child Development; Child, Preschool; Cocaine; Cocaine-Related Disorders; Et

1999
The methadone-maintained pregnancy.
    Clinics in perinatology, 1999, Volume: 26, Issue:1

    Topics: Comprehensive Health Care; Delivery, Obstetric; Embryonic and Fetal Development; Family Health; Fema

1999
[Preventing HIV infection: an exercise in evaluating scientific evidence in public health].
    Enfermedades infecciosas y microbiologia clinica, 1999, Volume: 17 Suppl 2

    Topics: Adult; Anti-HIV Agents; Biological Products; Clinical Trials as Topic; Evidence-Based Medicine; Fema

1999
[Special problems of HIV-positive women who are either drug abusers or on methadone replacement therapy].
    Zentralblatt fur Gynakologie, 1999, Volume: 121, Issue:11

    Topics: Cocaine; Drug Administration Schedule; Female; Germany; Heroin; HIV Infections; HIV Protease Inhibit

1999
[Pregnancy and drug abuse: current situation and therapeutic strategies].
    Annales de medecine interne, 2000, Volume: 151 Suppl B

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Female; Fetal Growth Retardation; Hepatit

2000
Treatment of neonatal abstinence syndrome with breast milk containing methadone.
    The Journal of perinatal & neonatal nursing, 2002, Volume: 15, Issue:4

    Topics: Breast Feeding; Drug Administration Schedule; Female; Humans; Infant, Newborn; Labor, Obstetric; Met

2002
Clinical management of methadone dependence during pregnancy.
    The Journal of perinatal & neonatal nursing, 2001, Volume: 14, Issue:4

    Topics: Female; Fetus; Humans; Infant, Newborn; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Co

2001
Effects of narcotics on the reproductive system.
    Advances in sex hormone research, 1977, Volume: 3

    Topics: Adrenal Cortex; Animals; Corticosterone; Cortisone; Cyclic AMP; Female; Follicle Stimulating Hormone

1977
The effect of maternal narcotic addiction on the newborn infant.
    Psychological medicine, 1977, Volume: 7, Issue:4

    Topics: Abnormalities, Drug-Induced; Breast Feeding; Female; Fertility; Heroin Dependence; Humans; Infant Mo

1977
Drugs and chemicals associated with intrauterine growth deficiency.
    The Journal of reproductive medicine, 1978, Volume: 21, Issue:6

    Topics: Abnormalities, Drug-Induced; Adult; Aminopterin; Animals; Disease Models, Animal; Ethanol; Female; F

1978
Toxicology of LAAM.
    NIDA research monograph, 1976, Issue:8

    Topics: Animals; Behavior, Animal; Body Weight; Dogs; Dose-Response Relationship, Drug; Drinking; Drug Admin

1976
[The pharmacology of drugs (heroin, L-methadone, cocaine, hashish) and their effects on pregnancy, fetus and neonate].
    Der Gynakologe, 1991, Volume: 24, Issue:6

    Topics: Abnormalities, Drug-Induced; Amphetamine; Cannabinoids; Cocaine; Female; Fetus; Heroin; Humans; Infa

1991
[Findings in newborn infants following drug abuse or drug weaning in the mother].
    Der Gynakologe, 1991, Volume: 24, Issue:6

    Topics: Abnormalities, Drug-Induced; Adult; Female; Fetal Growth Retardation; Heroin Dependence; Humans; Inf

1991
[Drug abuse, pregnancy and HIV infection].
    Der Gynakologe, 1991, Volume: 24, Issue:6

    Topics: Adult; AIDS Serodiagnosis; Contraception Behavior; Female; HIV Infections; Humans; Methadone; Opport

1991
Narcotic use in pregnancy.
    Clinics in perinatology, 1991, Volume: 18, Issue:1

    Topics: Female; Humans; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Complications; Prevalence;

1991
Methadone maintenance in the treatment of opioid dependence. A current perspective.
    The Western journal of medicine, 1990, Volume: 152, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Attitude of Health Personnel; Cocaine; Drug Interactions; Ethano

1990
Behavior and development patterns in children born to heroin-addicted and methadone-addicted mothers.
    Journal of the National Medical Association, 1988, Volume: 80, Issue:11

    Topics: Child; Child Behavior Disorders; Child, Preschool; Developmental Disabilities; Female; Heroin; Human

1988
Perinatal exposure to methadone: how do early biochemical alterations cause neurofunctional disturbances?
    Progress in brain research, 1988, Volume: 73

    Topics: Adrenergic Fibers; Animals; Brain; Catecholamines; Female; Methadone; Pregnancy; Prenatal Exposure D

1988
Plasma drug binding: implications for anesthesiologists.
    Anesthesia and analgesia, 1986, Volume: 65, Issue:7

    Topics: Age Factors; Alfentanil; Alprenolol; Anesthesia; Anesthetics; Blood Proteins; Bupivacaine; Burns; Ca

1986
Treatment perspectives in drug misuse: the opiate paradigm.
    Pharmacology & therapeutics, 1987, Volume: 35, Issue:3

    Topics: Endorphins; Female; History, 18th Century; History, 19th Century; History, 20th Century; Humans; Mal

1987
Developmental effects of narcotics.
    Neurotoxicology, 1986,Summer, Volume: 7, Issue:2

    Topics: Analysis of Variance; Animals; Body Weight; Female; Fetal Diseases; Growth; Humans; Methadone; Nalox

1986
The drug user as a parent.
    The International journal of the addictions, 1985, Volume: 20, Issue:1

    Topics: Child Development; Child Rearing; Child, Preschool; Curriculum; Female; Humans; Infant; Infant, Newb

1985
Maternal and neonatal metabolism of analgesic drugs.
    British journal of anaesthesia, 1973, Volume: 45

    Topics: Administration, Oral; Amniotic Fluid; Amphetamine; Analgesics; Biological Transport; Blood; Chlorpro

1973
Methadone.
    Canadian Medical Association journal, 1973, Oct-06, Volume: 109, Issue:7

    Topics: Acetates; Administration, Oral; Adolescent; American Medical Association; Canada; Chemical Phenomena

1973
Narcotic poisoning of children (1) through accidental ingestion of methadone and (2) in utero.
    Pediatrics, 1974, Volume: 54, Issue:3

    Topics: Administration, Oral; Apgar Score; Birth Weight; Child; Child Care; Female; Gestational Age; Heroin

1974

Trials

60 trials available for methadone and Pregnancy

ArticleYear
Pragmatic, randomized, blinded trial to shorten pharmacologic treatment of newborns with neonatal opioid withdrawal syndrome (NOWS).
    Trials, 2023, Jul-21, Volume: 24, Issue:1

    Topics: Analgesics, Opioid; Family; Female; Humans; Infant, Newborn; Methadone; Morphine; Neonatal Abstinenc

2023
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
Neonatal Abstinence Syndrome Severity Index Predicts 18-Month Neurodevelopmental Outcome in Neonates Randomized to Morphine or Methadone.
    The Journal of pediatrics, 2020, Volume: 227

    Topics: Analgesics, Opioid; Cluster Analysis; Female; Humans; Infant; Infant, Newborn; Length of Stay; Male;

2020
Precision dosing of methadone during pregnancy: A pharmacokinetics virtual clinical trials study.
    Journal of substance abuse treatment, 2021, Volume: 130

    Topics: Female; Humans; Methadone; Opioid-Related Disorders; Pregnancy

2021
Randomized Clinical Trial of Standard- Versus High-Calorie Formula for Methadone-Exposed Infants: A Feasibility Study.
    Hospital pediatrics, 2018, Volume: 8, Issue:1

    Topics: Double-Blind Method; Energy Intake; Feasibility Studies; Female; Humans; Infant Formula; Infant, New

2018
Prenatal exposure to methadone or buprenorphine: Early childhood developmental outcomes.
    Drug and alcohol dependence, 2018, 04-01, Volume: 185

    Topics: Adult; Buprenorphine; Child Development; Child, Preschool; Cognition; Female; Humans; Infant, Newbor

2018
Evaluation of methadone concentrations in bitches and in umbilical cords after epidural or systemic administration for caesarean section: A randomized trial.
    Veterinary anaesthesia and analgesia, 2019, Volume: 46, Issue:3

    Topics: Analgesics, Opioid; Anesthesia; Anesthesia, Epidural; Animals; Cesarean Section; Dogs; Female; Injec

2019
Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention.
    Drug and alcohol dependence, 2013, Sep-01, Volume: 132, Issue:1-2

    Topics: Adult; Analysis of Variance; Buprenorphine; Confidence Intervals; Diagnostic and Statistical Manual

2013
Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention.
    Drug and alcohol dependence, 2013, Sep-01, Volume: 132, Issue:1-2

    Topics: Adult; Analysis of Variance; Buprenorphine; Confidence Intervals; Diagnostic and Statistical Manual

2013
Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention.
    Drug and alcohol dependence, 2013, Sep-01, Volume: 132, Issue:1-2

    Topics: Adult; Analysis of Variance; Buprenorphine; Confidence Intervals; Diagnostic and Statistical Manual

2013
Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention.
    Drug and alcohol dependence, 2013, Sep-01, Volume: 132, Issue:1-2

    Topics: Adult; Analysis of Variance; Buprenorphine; Confidence Intervals; Diagnostic and Statistical Manual

2013
Nonserious adverse events in randomized trials with opioid-dependent pregnant women: direct versus indirect measurement.
    The American journal on addictions, 2012, Volume: 21 Suppl 1

    Topics: Analgesics, Opioid; Buprenorphine; Data Collection; Double-Blind Method; Female; Humans; Infant, New

2012
Design considerations for point-of-care clinical trials comparing methadone and buprenorphine treatment for opioid dependence in pregnancy and for neonatal abstinence syndrome.
    Contemporary clinical trials, 2014, Volume: 39, Issue:1

    Topics: Adult; Birth Weight; Buprenorphine; Female; Humans; Infant, Newborn; Length of Stay; Methadone; Neon

2014
The effect of prenatal alcohol co-exposure on neonatal abstinence syndrome in infants born to mothers in opioid maintenance treatment.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2016, Volume: 29, Issue:5

    Topics: Adult; Alcohol Drinking; Female; Humans; Incidence; Infant, Newborn; Length of Stay; Methadone; Neon

2016
Psychometric assessment of the Neonatal Abstinence Scoring System and the MOTHER NAS Scale.
    The American journal on addictions, 2016, Volume: 25, Issue:5

    Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Absti

2016
Newborn birth-weight of pregnant women on methadone or buprenorphine maintenance treatment: A national contingency management approach trial.
    The American journal on addictions, 2017, Volume: 26, Issue:2

    Topics: Adult; Age of Onset; Alcohol Drinking; Birth Weight; Buprenorphine; Cigarette Smoking; Female; Human

2017
Correlations of maternal buprenorphine dose, buprenorphine, and metabolite concentrations in meconium with neonatal outcomes.
    Clinical pharmacology and therapeutics, 2008, Volume: 84, Issue:5

    Topics: Adult; Buprenorphine; Cocaine; Double-Blind Method; Female; Humans; Infant, Newborn; Male; Maternal

2008
Maternal methadone dosing schedule and fetal neurobehaviour.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2009, Volume: 22, Issue:1

    Topics: Adult; Behavior; Cognition; Drug Administration Schedule; Female; Fetal Monitoring; Fetal Movement;

2009
Smoking in pregnant women screened for an opioid agonist medication study compared to related pregnant and non-pregnant patient samples.
    The American journal of drug and alcohol abuse, 2009, Volume: 35, Issue:5

    Topics: Adult; Cocaine-Related Disorders; Female; Health Behavior; Humans; Methadone; Narcotics; Opioid-Rela

2009
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
    The New England journal of medicine, 2010, Dec-09, Volume: 363, Issue:24

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn;

2010
(R)- and (S)-methadone and buprenorphine concentration ratios in maternal and umbilical cord plasma following chronic maintenance dosing in pregnancy.
    British journal of clinical pharmacology, 2010, Volume: 70, Issue:6

    Topics: Analgesics, Opioid; Buprenorphine; Drug Administration Schedule; Female; Fetal Blood; Humans; Infant

2010
Maternal methadone dose, placental methadone concentrations, and neonatal outcomes.
    Clinical chemistry, 2011, Volume: 57, Issue:3

    Topics: Analgesics, Opioid; Apgar Score; Birth Weight; Body Size; Cephalometry; Cocaine; Female; Gestational

2011
Treating the partners of opioid-dependent pregnant patients: feasibility and efficacy.
    The American journal of drug and alcohol abuse, 2011, Volume: 37, Issue:3

    Topics: Adult; Counseling; Feasibility Studies; Female; Humans; Interpersonal Relations; Interview, Psycholo

2011
Randomized controlled trials in pregnancy: scientific and ethical aspects. Exposure to different opioid medications during pregnancy in an intra-individual comparison.
    Addiction (Abingdon, England), 2011, Volume: 106, Issue:7

    Topics: Adult; Analgesics, Opioid; Birth Weight; Buprenorphine; Double-Blind Method; Female; Humans; Infant,

2011
Buprenorphine versus methadone in pregnant opioid-dependent women: a prospective multicenter study.
    European journal of clinical pharmacology, 2011, Volume: 67, Issue:10

    Topics: Adult; Analgesics, Opioid; Birth Weight; Buprenorphine; Female; Heroin; Heroin Dependence; Humans; I

2011
Methadone, cocaine, opiates, and metabolite disposition in umbilical cord and correlations to maternal methadone dose and neonatal outcomes.
    Therapeutic drug monitoring, 2011, Volume: 33, Issue:4

    Topics: Adult; Analgesics, Opioid; Buprenorphine; Cocaine; Dose-Response Relationship, Drug; Female; Humans;

2011
Impact of treatment approach on maternal and neonatal outcome in pregnant opioid-maintained women.
    Human psychopharmacology, 2011, Volume: 26, Issue:6

    Topics: Adult; Austria; Birth Weight; Buprenorphine; Double-Blind Method; Female; Gestational Age; Humans; I

2011
Are male neonates more vulnerable to neonatal abstinence syndrome than female neonates?
    Gender medicine, 2011, Volume: 8, Issue:6

    Topics: Birth Weight; Buprenorphine; Double-Blind Method; Female; Humans; Infant, Newborn; Male; Methadone;

2011
Influence of site differences between urban and rural American and Central European opioid-dependent pregnant women and neonatal outcome characteristics.
    European addiction research, 2012, Volume: 18, Issue:3

    Topics: Adolescent; Adult; Buprenorphine; Double-Blind Method; Europe; Female; Humans; Infant, Newborn; Meth

2012
Peripartum pain management in opioid dependent women.
    European journal of pain (London, England), 2012, Volume: 16, Issue:4

    Topics: Adult; Analgesics; Buprenorphine; Cesarean Section; Delivery, Obstetric; Dose-Response Relationship,

2012
Contingent incentives reduce cigarette smoking among pregnant, methadone-maintained women: results of an initial feasibility and efficacy randomized clinical trial.
    Addiction (Abingdon, England), 2012, Volume: 107, Issue:10

    Topics: Adult; Behavior Therapy; Carbon Monoxide; Feasibility Studies; Female; Humans; Methadone; Motivation

2012
Illicit drug use among pregnant women enrolled in treatment for cigarette smoking cessation.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2013, Volume: 15, Issue:5

    Topics: Adult; Analgesics, Opioid; Benzodiazepines; Cannabis; Cocaine; Demography; Female; Humans; Illicit D

2013
Maternal Opioid Treatment: Human Experimental Research (MOTHER) Study: maternal, fetal and neonatal outcomes from secondary analyses.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Adolescent; Adult; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Sy

2012
Fetal assessment before and after dosing with buprenorphine or methadone.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Adolescent; Adult; Analgesics, Opioid; Biophysical Phenomena; Buprenorphine; Double-Blind Method; Fe

2012
Predicting treatment for neonatal abstinence syndrome in infants born to women maintained on opioid agonist medication.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Adolescent; Adult; Analgesics, Opioid; Birth Weight; Buprenorphine; Dose-Response Relationship, Drug

2012
Differences in the profile of neonatal abstinence syndrome signs in methadone- versus buprenorphine-exposed neonates.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Adult; Analgesics, Opioid; Analysis of Variance; Buprenorphine; Double-Blind Method; Female; Humans;

2012
Neonatal neurobehavior effects following buprenorphine versus methadone exposure.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Infant Behavior; Infant, Newbo

2012
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind

2012
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind

2012
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind

2012
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind

2012
Infections and obstetric outcomes in opioid-dependent pregnant women maintained on methadone or buprenorphine.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Adolescent; Adult; Analgesics, Opioid; Analysis of Variance; Buprenorphine; Communicable Diseases; F

2012
Effect of hepatitis C virus status on liver enzymes in opioid-dependent pregnant women maintained on opioid-agonist medication.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Female; gamma-Glutamyltransferase; Hepatitis C

2012
Lessons learned from a comparison of evidence-based research in pregnant opioid-dependent women.
    Human psychopharmacology, 2013, Volume: 28, Issue:1

    Topics: Adolescent; Adult; Buprenorphine; Double-Blind Method; Evidence-Based Medicine; Female; Humans; Infa

2013
A comparison of cigarette smoking profiles in opioid-dependent pregnant patients receiving methadone or buprenorphine.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2013, Volume: 15, Issue:7

    Topics: Adolescent; Adult; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-R

2013
Motivational enhancement therapy for nicotine dependence in methadone-maintained pregnant women.
    Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors, 2004, Volume: 18, Issue:3

    Topics: Adolescent; Adult; Analysis of Variance; Female; Humans; Linear Models; Methadone; Motivation; Opioi

2004
Therapy of the neonatal abstinence syndrome with tincture of opium or morphine drops.
    Drug and alcohol dependence, 2005, Jan-07, Volume: 77, Issue:1

    Topics: Double-Blind Method; Female; Humans; Infant, Newborn; Male; Methadone; Morphine; Neonatal Abstinence

2005
Randomized controlled study transitioning opioid-dependent pregnant women from short-acting morphine to buprenorphine or methadone.
    Drug and alcohol dependence, 2005, Apr-04, Volume: 78, Issue:1

    Topics: Adult; Buprenorphine; Double-Blind Method; Female; Humans; Methadone; Morphine; Opioid-Related Disor

2005
Buprenorphine versus methadone in the treatment of pregnant opioid-dependent patients: effects on the neonatal abstinence syndrome.
    Drug and alcohol dependence, 2005, Volume: 79, Issue:1

    Topics: Administration, Sublingual; Adult; Buprenorphine; Double-Blind Method; Female; Heroin Dependence; Hu

2005
Methadone versus buprenorphine in pregnant addicts: a double-blind, double-dummy comparison study.
    Addiction (Abingdon, England), 2006, Volume: 101, Issue:2

    Topics: Buprenorphine; Double-Blind Method; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence

2006
Management of neonatal abstinence syndrome in neonates born to opioid maintained women.
    Drug and alcohol dependence, 2007, Mar-16, Volume: 87, Issue:2-3

    Topics: Adult; Apgar Score; Female; Gestational Age; Humans; Infant, Newborn; Male; Methadone; Morphine; Neo

2007
Maternal vagal tone change in response to methadone is associated with neonatal abstinence syndrome severity in exposed neonates.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2007, Volume: 20, Issue:9

    Topics: Adult; Apgar Score; Arrhythmia, Sinus; Electrocardiography; Female; Heart; Humans; Infant, Newborn;

2007
Prospective randomised comparative study of the effect of buprenorphine, methadone and heroin on the course of pregnancy, birthweight of newborns, early postpartum adaptation and course of the neonatal abstinence syndrome (NAS) in women followed up in the
    Neuro endocrinology letters, 2008, Volume: 29, Issue:1

    Topics: Adult; Birth Weight; Buprenorphine; Female; Fetal Growth Retardation; Heroin; Heroin Dependence; Hum

2008
Neonatal methadone withdrawal. Effect of two treatment regimens.
    American journal of diseases of children (1960), 1983, Volume: 137, Issue:12

    Topics: Blood Pressure; Carbon Dioxide; Drug Administration Schedule; Female; Humans; Hydrogen-Ion Concentra

1983
Postoperative analgesia for Caesarean section using epidural methadone.
    Anaesthesia, 1984, Volume: 39, Issue:1

    Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Bupivacaine; Cesarean Section; Double-Blind Method; E

1984
Methadone dosing and pregnancy: impact on program compliance.
    The International journal of the addictions, 1995, Volume: 30, Issue:2

    Topics: Ambulatory Care; Cocaine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hu

1995
Comparison of epidural methadone with epidural diamorphine for analgesia following caesarean section.
    Acta anaesthesiologica Scandinavica, 1993, Volume: 37, Issue:4

    Topics: Analgesia, Epidural; Analgesia, Obstetrical; Cesarean Section; Double-Blind Method; Female; Heroin;

1993
Evaluation of a cognitive-behavioural intervention for pregnant injecting drug users at risk of HIV infection.
    Addiction (Abingdon, England), 1996, Volume: 91, Issue:8

    Topics: Adult; Cognitive Behavioral Therapy; Combined Modality Therapy; Female; Follow-Up Studies; Health Kn

1996
Attendance incentives for outpatient treatment: effects in methadone- and nonmethadone-maintained pregnant drug dependent women.
    Drug and alcohol dependence, 1997, Oct-25, Volume: 48, Issue:1

    Topics: Adolescent; Adult; Ambulatory Care; Black or African American; Cocaine; Female; Humans; Infant, Newb

1997
Comparison of methadone and slow-release morphine maintenance in pregnant addicts.
    Addiction (Abingdon, England), 1999, Volume: 94, Issue:2

    Topics: Adolescent; Adult; Delayed-Action Preparations; Female; Humans; Infant, Newborn; Methadone; Morphine

1999
Slow-release morphine was not more effective than methadone in reducing neonatal abstinence syndrome.
    The Western journal of medicine, 2000, Volume: 172, Issue:1

    Topics: Adult; Delayed-Action Preparations; Female; Humans; Infant, Newborn; Methadone; Morphine; Narcotics;

2000
The effectiveness of incentives in enhancing treatment attendance and drug abstinence in methadone-maintained pregnant women.
    Drug and alcohol dependence, 2001, Feb-01, Volume: 61, Issue:3

    Topics: Adult; Analysis of Variance; Chi-Square Distribution; Cocaine-Related Disorders; Female; Heroin Depe

2001
A reinforcement-based therapeutic workplace for the treatment of drug abuse: six-month abstinence outcomes.
    Experimental and clinical psychopharmacology, 2001, Volume: 9, Issue:1

    Topics: Adult; Cocaine-Related Disorders; Female; Heroin Dependence; Humans; Methadone; Narcotics; Pregnancy

2001
[Withdrawal syndromes of newborns of pregnant drug abusers maintained under methadone or high-dose buprenorphine: 246 cases].
    Annales de medecine interne, 2001, Volume: 152 Suppl 7

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Morphine; Neonatal Ab

2001
Phase III clinical study of levo-alpha-acetylmethadol.
    NIDA research monograph, 1976, Issue:8

    Topics: Clinical Trials as Topic; Drug Evaluation; Drug Interactions; Emotions; Female; Follow-Up Studies; H

1976
Extradural methadone and bupivacaine in labour.
    British journal of anaesthesia, 1990, Volume: 65, Issue:3

    Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Bupivacaine; Double-Blind Method; Female; Humans

1990

Other Studies

834 other studies available for methadone and Pregnancy

ArticleYear
Opioid Use Disorder and Perinatal Outcomes.
    Pediatrics, 2021, Volume: 148, Issue:4

    Topics: Adult; Analgesics, Opioid; British Columbia; Buprenorphine; Female; Humans; Incidence; Infant, Newbo

2021
A retrospective, observational study on medication for opioid use disorder during pregnancy and risk for neonatal abstinence syndrome.
    Family practice, 2022, 03-24, Volume: 39, Issue:2

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant; Infant, Newborn; Methadone; Neonatal Abst

2022
Use of Methadone Maintenance Therapy for Opioid Use Disorder in Pregnancy.
    NeoReviews, 2021, Volume: 22, Issue:10

    Topics: Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Pregnancy

2021
Histological Changes Observed in Placentas Exposed to Medication-Assisted Treatment.
    Journal of pregnancy, 2021, Volume: 2021

    Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Opiate Substitution Treatment; Placenta;

2021
Examining differences in retention on medication for opioid use disorder: An analysis of Ohio Medicaid data.
    Journal of substance abuse treatment, 2022, Volume: 136

    Topics: Adolescent; Analgesics, Opioid; Buprenorphine; Female; Humans; Medicaid; Methadone; Naltrexone; Ohio

2022
Neonatal Abstinence Syndrome: Prevention, Recognition, Treatment, and Follow-up.
    South Dakota medicine : the journal of the South Dakota State Medical Association, 2021, Volume: 74, Issue:12

    Topics: Analgesics, Opioid; Child, Preschool; Female; Follow-Up Studies; Humans; Infant, Newborn; Methadone;

2021
Infant urinary metabolomic profile in a fatal acute methadone intoxication.
    International journal of legal medicine, 2022, Volume: 136, Issue:2

    Topics: Asphyxia; Female; Humans; Infant; Infant, Newborn; Magnetic Resonance Spectroscopy; Metabolomics; Me

2022
Harm Reduction for Patients With Substance Use Disorders.
    American family physician, 2022, 01-01, Volume: 105, Issue:1

    Topics: Adult; Buprenorphine; Contraception; Drug Overdose; Female; Harm Reduction; Heroin; Humans; Male; Me

2022
Risk factors for preterm birth among gravid individuals receiving buprenorphine for opioid use disorder.
    American journal of obstetrics & gynecology MFM, 2022, Volume: 4, Issue:3

    Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Opioid-Related Disorders; Placenta; Pregn

2022
Does self-reported consumption of heroin correlate with dose of methadone among pregnant people with opioid use disorder?
    American journal of obstetrics & gynecology MFM, 2022, Volume: 4, Issue:3

    Topics: Analgesics, Opioid; Female; Heroin; Humans; Methadone; Opioid-Related Disorders; Pregnancy; Retrospe

2022
Trends in the severity of opioid use disorder during pregnancy over time.
    Journal of perinatology : official journal of the California Perinatal Association, 2022, Volume: 42, Issue:8

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-

2022
Prenatal opioid exposure reprograms the behavioural response to future alcohol reward.
    Addiction biology, 2022, Volume: 27, Issue:2

    Topics: Analgesics, Opioid; Animals; Ethanol; Female; Male; Methadone; Mice; Pregnancy; Prenatal Exposure De

2022
"You have to take this medication, but then you get punished for taking it:" lack of agency, choice, and fear of medications to treat opioid use disorder across the perinatal period.
    Journal of substance abuse treatment, 2022, Volume: 139

    Topics: Analgesics, Opioid; Buprenorphine; Child; Fear; Female; Humans; Infant, Newborn; Methadone; Opiate S

2022
Neonatal Opioid Withdrawal Syndrome: A Comparison of As-Needed Pharmacotherapy.
    Hospital pediatrics, 2022, 05-01, Volume: 12, Issue:5

    Topics: Analgesics, Opioid; Female; Humans; Infant; Infant, Newborn; Methadone; Morphine; Neonatal Abstinenc

2022
Association of Duration of Methadone or Buprenorphine Use During Pregnancy With Risk of Nonfatal Drug Overdose Among Pregnant Persons With Opioid Use Disorder in the US.
    JAMA network open, 2022, 04-01, Volume: 5, Issue:4

    Topics: Buprenorphine; Drug Overdose; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Relat

2022
Perinatal methadone exposure attenuates myelination and induces oligodendrocyte apoptosis in neonatal rat brain.
    Experimental biology and medicine (Maywood, N.J.), 2022, Volume: 247, Issue:12

    Topics: Animals; Animals, Newborn; Apoptosis; Brain; Female; Male; Methadone; Myelin Sheath; Oligodendroglia

2022
Impact of prenatal substance use policies on commercially insured pregnant females with opioid use disorder.
    Journal of substance abuse treatment, 2022, Volume: 140

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opiate Overdose; Opiate Substitution T

2022
Buprenorphine uptake during pregnancy following the 2017 guidelines update on prenatal opioid use disorder.
    American journal of obstetrics and gynecology, 2022, Volume: 227, Issue:3

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-

2022
Verbal and nonverbal memory in school-aged children born to opioid-dependent mothers.
    Early human development, 2022, Volume: 171

    Topics: Analgesics, Opioid; Buprenorphine; Child; Female; Humans; Longitudinal Studies; Methadone; Opiate Su

2022
Characteristics of Prescription Opioid Analgesics in Pregnancy and Risk of Neonatal Opioid Withdrawal Syndrome in Newborns.
    JAMA network open, 2022, 08-01, Volume: 5, Issue:8

    Topics: Adult; Analgesics, Opioid; Codeine; Cohort Studies; Female; Humans; Hydrocodone; Hydromorphone; Infa

2022
Prenatal methadone exposure leads to long-term memory impairments and disruptions of dentate granule cell function in a sex-dependent manner.
    Addiction biology, 2022, Volume: 27, Issue:5

    Topics: Analgesics, Opioid; Animals; Dentate Gyrus; Female; Humans; Male; Memory, Long-Term; Methadone; Preg

2022
Attitudes toward Medication for Opioid Use Disorder among Substance Use Treatment Providers.
    Substance use & misuse, 2022, Volume: 57, Issue:12

    Topics: Analgesics, Opioid; Buprenorphine; Child; Female; Humans; Methadone; Naltrexone; Opiate Substitution

2022
Spatial and Nonspatial Factors Associated with Access to Medication for Opioid Use Disorder among Pregnant Women in Massachusetts.
    Substance use & misuse, 2022, Volume: 57, Issue:13

    Topics: Analgesics, Opioid; Buprenorphine; Female; Health Services Accessibility; Humans; Massachusetts; Met

2022
Alterations of brain microstructures in a mouse model of prenatal opioid exposure detected by diffusion MRI.
    Scientific reports, 2022, 10-12, Volume: 12, Issue:1

    Topics: Analgesics, Opioid; Animals; Brain; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging;

2022
Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.
    The New England journal of medicine, 2022, 12-01, Volume: 387, Issue:22

    Topics: Buprenorphine; Cesarean Section; Cohort Studies; Female; Humans; Infant; Infant, Low Birth Weight; I

2022
Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.
    The New England journal of medicine, 2022, 12-01, Volume: 387, Issue:22

    Topics: Buprenorphine; Cesarean Section; Cohort Studies; Female; Humans; Infant; Infant, Low Birth Weight; I

2022
Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.
    The New England journal of medicine, 2022, 12-01, Volume: 387, Issue:22

    Topics: Buprenorphine; Cesarean Section; Cohort Studies; Female; Humans; Infant; Infant, Low Birth Weight; I

2022
Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.
    The New England journal of medicine, 2022, 12-01, Volume: 387, Issue:22

    Topics: Buprenorphine; Cesarean Section; Cohort Studies; Female; Humans; Infant; Infant, Low Birth Weight; I

2022
Association of medication-assisted treatment and short acting opioids with newborn head circumference and birth weight.
    Journal of perinatology : official journal of the California Perinatal Association, 2023, Volume: 43, Issue:3

    Topics: Analgesics, Opioid; Birth Weight; Buprenorphine; Cesarean Section; Female; Humans; Infant, Newborn;

2023
Association of medication-assisted treatment and short acting opioids with newborn head circumference and birth weight.
    Journal of perinatology : official journal of the California Perinatal Association, 2023, Volume: 43, Issue:3

    Topics: Analgesics, Opioid; Birth Weight; Buprenorphine; Cesarean Section; Female; Humans; Infant, Newborn;

2023
Association of medication-assisted treatment and short acting opioids with newborn head circumference and birth weight.
    Journal of perinatology : official journal of the California Perinatal Association, 2023, Volume: 43, Issue:3

    Topics: Analgesics, Opioid; Birth Weight; Buprenorphine; Cesarean Section; Female; Humans; Infant, Newborn;

2023
Association of medication-assisted treatment and short acting opioids with newborn head circumference and birth weight.
    Journal of perinatology : official journal of the California Perinatal Association, 2023, Volume: 43, Issue:3

    Topics: Analgesics, Opioid; Birth Weight; Buprenorphine; Cesarean Section; Female; Humans; Infant, Newborn;

2023
Buprenorphine-naloxone, buprenorphine, and methadone throughout pregnancy in maternal opioid use disorder.
    Acta obstetricia et gynecologica Scandinavica, 2023, Volume: 102, Issue:3

    Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Female; Humans; Illicit

2023
How does a clinician approach the pharmacological management of opioid use disorders in pregnant women and pregnant people?
    Expert opinion on pharmacotherapy, 2023, Volume: 24, Issue:4

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-

2023
Comparative Safety Analysis of Opioid Agonist Treatment in Pregnant Women with Opioid Use Disorder: A Population-Based Study.
    Drug safety, 2023, Volume: 46, Issue:3

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence S

2023
Buprenorphine versus Methadone in Pregnancy.
    The New England journal of medicine, 2023, Mar-09, Volume: 388, Issue:10

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opioid-Related Disorders; Pregnancy

2023
Buprenorphine versus Methadone in Pregnancy. Reply.
    The New England journal of medicine, 2023, Mar-09, Volume: 388, Issue:10

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opioid-Related Disorders; Pregnancy

2023
Initiation and Treatment Discontinuation of Medications for Opioid Use Disorder in Pregnant People Compared With Nonpregnant People.
    Obstetrics and gynecology, 2023, 04-01, Volume: 141, Issue:4

    Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment;

2023
Treatment access for opioid use disorder among women with medicaid in Florida.
    Drug and alcohol dependence, 2023, 05-01, Volume: 246

    Topics: Analgesics, Opioid; Buprenorphine; Female; Florida; Humans; Medicaid; Methadone; Opiate Substitution

2023
United States county jail treatment and care of pregnant incarcerated persons with opioid use disorder.
    Drug and alcohol dependence, 2023, 06-01, Volume: 247

    Topics: Analgesics, Opioid; Buprenorphine; Cross-Sectional Studies; Female; Humans; Jails; Methadone; Opiate

2023
Feasibility of methadone for pain relief in first trimester abortion.
    Contraception, 2023, Volume: 125

    Topics: Abortion, Induced; Feasibility Studies; Female; Humans; Methadone; Pain; Pain Management; Pregnancy;

2023
Feasibility of methadone for pain relief in first trimester abortion (Boston, Massachusetts 2022).
    Contraception, 2023, Volume: 125

    Topics: Abortion, Induced; Boston; Feasibility Studies; Female; Humans; Massachusetts; Methadone; Pain; Preg

2023
Methadone alters transcriptional programs associated with synapse formation in human cortical organoids.
    Translational psychiatry, 2023, 05-06, Volume: 13, Issue:1

    Topics: Analgesics, Opioid; Brain; Female; Humans; Infant; Methadone; Opiate Substitution Treatment; Opioid-

2023
Effect of Neonatal Abstinence Syndrome Treatment Status and Maternal Depressive Symptomatology on Maternal Reports of Infant Behaviors.
    Journal of pediatric psychology, 2023, 07-05, Volume: 48, Issue:6

    Topics: Analgesics, Opioid; Female; Humans; Infant; Infant, Newborn; Methadone; Mothers; Neonatal Abstinence

2023
A comparison of postpartum opioid consumption and opioid discharge prescriptions among opioid-naïve patients and those with opioid use disorder.
    American journal of obstetrics & gynecology MFM, 2023, Volume: 5, Issue:8

    Topics: Analgesics, Opioid; Buprenorphine; Drug Prescriptions; Female; Humans; Methadone; Morphine Derivativ

2023
Trends in smoking during pregnancy stratified by the use of opioid agonist therapy and the contribution of smoking to poor outcome in neonates prenatally exposed to opioid agonist treatment.
    Archives of women's mental health, 2023, Volume: 26, Issue:4

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Opiate Substitution T

2023
Perturbed neurochemical and microstructural organization in a mouse model of prenatal opioid exposure: A multi-modal magnetic resonance study.
    PloS one, 2023, Volume: 18, Issue:7

    Topics: Analgesics, Opioid; Animals; Brain; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging;

2023
Methadone administered to rat dams during pregnancy and lactation affects the circadian rhythms of their pups.
    Journal of neuroscience research, 2023, Volume: 101, Issue:11

    Topics: Animals; Circadian Rhythm; Female; Lactation; Melatonin; Methadone; Pineal Gland; Pregnancy; Rats; S

2023
Long-Term Visual and Neurodevelopmental Outcomes in Two Children with Congenital Nystagmus Secondary to Methadone Exposure In utero.
    Neuropediatrics, 2023, Volume: 54, Issue:6

    Topics: Child; Female; Humans; Infant; Methadone; Nystagmus, Congenital; Pregnancy; Prenatal Exposure Delaye

2023
Distribution of morphine and methadone to the brain in a developmental chicken embryo model.
    Toxicology and applied pharmacology, 2023, Nov-15, Volume: 479

    Topics: Analgesics, Opioid; Animals; Brain; Chick Embryo; Chickens; Chromatography, Liquid; Drug Tolerance;

2023
Health and Neurodevelopment of Children Born to Opioid-Dependent Mothers at School Entry.
    Journal of developmental and behavioral pediatrics : JDBP, 2020, Volume: 41, Issue:1

    Topics: Child of Impaired Parents; Child, Preschool; Female; Health Status; Humans; Infant; Infant, Newborn;

2020
Prenatal exposure to opioid maintenance treatment and neonatal outcomes: Nationwide registry studies from the Czech Republic and Norway.
    Pharmacology research & perspectives, 2019, Volume: 7, Issue:5

    Topics: Adult; Buprenorphine; Child Development; Czech Republic; Female; Humans; Infant, Newborn; Logistic M

2019
Management of Newborns with Prenatal Opioid Exposure: One Institution's Journey.
    Clinical therapeutics, 2019, Volume: 41, Issue:9

    Topics: Analgesics, Opioid; Female; Humans; Infant, Newborn; Length of Stay; Methadone; Morphine; Neonatal A

2019
Drug screening during pregnancy: Urine dip cups measure up.
    Drug and alcohol dependence, 2019, 11-01, Volume: 204

    Topics: Amphetamines; Analgesics, Opioid; Benzodiazepines; Buprenorphine; Cocaine; Female; Humans; Laborator

2019
Salivary cortisol levels relate to cognitive performance in children prenatally exposed to methadone or buprenorphine.
    Developmental psychobiology, 2020, Volume: 62, Issue:3

    Topics: Analgesics, Opioid; Buprenorphine; Child; Child Development; Cohort Studies; Female; Humans; Hydroco

2020
Methadone, Buprenorphine, or Detoxification for Management of Perinatal Opioid Use Disorder: A Cost-Effectiveness Analysis.
    Obstetrics and gynecology, 2019, Volume: 134, Issue:5

    Topics: Buprenorphine; Cost-Benefit Analysis; Decision Support Techniques; Female; Humans; Methadone; Narcot

2019
Educational achievement at age 9.5 years of children born to mothers maintained on methadone during pregnancy.
    PloS one, 2019, Volume: 14, Issue:10

    Topics: Achievement; Child; Educational Status; Female; Humans; Logistic Models; Male; Mathematics; Methadon

2019
Buprenorphine compared with methadone in opioid-dependent pregnant women: How does it affect neonatal abstinence syndrome?
    Journal of the American Association of Nurse Practitioners, 2019, Dec-04, Volume: 33, Issue:2

    Topics: Adult; Buprenorphine; Female; Humans; Infant; Infant, Newborn; Length of Stay; Methadone; Narcotic A

2019
Long-time effects of prenatal morphine, tramadol, methadone, and buprenorphine exposure on seizure and anxiety in immature rats.
    The International journal of neuroscience, 2020, Volume: 130, Issue:9

    Topics: Animals; Animals, Newborn; Anxiety; Behavior, Animal; Buprenorphine; Female; Locomotion; Male; Maze

2020
Diverse changes in myelin protein expression in rat brain after perinatal methadone exposure.
    Acta neurobiologiae experimentalis, 2019, Volume: 79, Issue:4

    Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; Animals; Brain; Female; Male; Methadone; Myelin Basic

2019
Substance use disorder treatment services for pregnant and postpartum women in residential and outpatient settings.
    Journal of substance abuse treatment, 2020, Volume: 110

    Topics: Buprenorphine; Female; Health Services Accessibility; Humans; Methadone; Opioid-Related Disorders; O

2020
Initial Management of Incarcerated Pregnant Women With Opioid Use Disorder.
    Journal of correctional health care : the official journal of the National Commission on Correctional Health Care, 2020, Volume: 26, Issue:1

    Topics: Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; P

2020
Stereoselective Analysis of Methadone and EDDP in Laboring Women and Neonates in Plasma and Dried Blood Spots and Association with Neonatal Abstinence Syndrome.
    American journal of perinatology, 2021, Volume: 38, Issue:9

    Topics: Analgesics, Opioid; Anticonvulsants; Dried Blood Spot Testing; Female; Humans; Infant, Newborn; Labo

2021
Opioid use disorder incidence and treatment among incarcerated pregnant women in the United States: results from a national surveillance study.
    Addiction (Abingdon, England), 2020, Volume: 115, Issue:11

    Topics: Analgesics, Opioid; Buprenorphine; Cross-Sectional Studies; Female; Humans; Incidence; Methadone; Na

2020
Screening for Opioid and Stimulant Exposure In Utero Through Targeted and Untargeted Metabolomics Analysis of Umbilical Cords.
    Therapeutic drug monitoring, 2020, Volume: 42, Issue:5

    Topics: Analgesics, Opioid; Central Nervous System Stimulants; Chromatography, Liquid; Cocaine; Female; Huma

2020
Emerging therapies for the treatment of neonatal abstinence syndrome.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2022, Volume: 35, Issue:5

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Morphine; Neonatal Ab

2022
Methadone, Buprenorphine, or Detoxification for Management of Perinatal Opioid Use Disorder: A Cost-Effectiveness Analysis.
    Obstetrics and gynecology, 2020, Volume: 135, Issue:4

    Topics: Buprenorphine; Cost-Benefit Analysis; Female; Humans; Infant, Newborn; Methadone; Opiate Substitutio

2020
Necrotizing enterocolitis and its association with the neonatal abstinence syndrome.
    Journal of neonatal-perinatal medicine, 2020, Volume: 13, Issue:1

    Topics: Analgesics, Opioid; Buprenorphine; Cohort Studies; Enterocolitis, Necrotizing; Female; Fetal Blood;

2020
Pregnant Smokers Receiving Opioid Agonist Therapy Have an Elevated Nicotine Metabolite Ratio: A Replication Study.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2020, 10-08, Volume: 22, Issue:10

    Topics: Analgesics, Opioid; Bupropion; Cotinine; Female; Humans; Methadone; Nicotine; Opiate Substitution Tr

2020
Living a normal life? Follow-up study of women who had been in opioid maintenance treatment during pregnancy.
    Journal of substance abuse treatment, 2020, Volume: 113

    Topics: Buprenorphine; Child; Female; Follow-Up Studies; Humans; Methadone; Opiate Substitution Treatment; O

2020
Prenatal exposure to methadone or buprenorphine impairs cognitive performance in young adult rats.
    Drug and alcohol dependence, 2020, 07-01, Volume: 212

    Topics: Animals; Animals, Newborn; Buprenorphine; Cognition; Female; Infusion Pumps, Implantable; Male; Memo

2020
Opioid Use Disorder Treatment Facilities With Programs for Special Populations.
    American journal of preventive medicine, 2020, Volume: 59, Issue:3

    Topics: Adolescent; Adult; Depression, Postpartum; Female; Humans; Infant, Newborn; Male; Methadone; Middle

2020
Assessment of Racial and Ethnic Disparities in the Use of Medication to Treat Opioid Use Disorder Among Pregnant Women in Massachusetts.
    JAMA network open, 2020, 05-01, Volume: 3, Issue:5

    Topics: Adult; Black or African American; Buprenorphine; Female; Healthcare Disparities; Hispanic or Latino;

2020
Pain outcomes among patients after cesarean consuming buprenorphine or methadone and opioid-naïve patients.
    Journal of clinical anesthesia, 2020, Volume: 65

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opioid-Related Disorders; Pain; Pregna

2020
Effects of polysubstance exposure on neonatal outcomes for infants with intrauterine opioid exposure.
    Journal of perinatology : official journal of the California Perinatal Association, 2020, Volume: 40, Issue:10

    Topics: Analgesics, Opioid; Female; Humans; Infant; Infant, Newborn; Length of Stay; Methadone; Morphine; Ne

2020
Comparison of buprenorphine and methadone in the management of maternal opioid use disorder in full term pregnancies.
    Journal of perinatal medicine, 2020, Sep-25, Volume: 48, Issue:7

    Topics: Birth Weight; Buprenorphine; Delivery, Obstetric; Female; Humans; Infant, Newborn; Length of Stay; M

2020
Medications for opioid use disorder in pregnancy in a state women's prison facility.
    Drug and alcohol dependence, 2020, 09-01, Volume: 214

    Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; North Carolina; Opioid-Related

2020
Adverse neonatal outcomes associated with maternal severe mental health diagnoses and opioid use.
    Journal of perinatology : official journal of the California Perinatal Association, 2020, Volume: 40, Issue:10

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Mental Health; Methadone; Neonat

2020
Drug abuse during pregnancy and its neonatal impact. Analysis of the periods 2002-2008 and 2009-2017.
    Medicina clinica, 2021, 08-27, Volume: 157, Issue:4

    Topics: Cocaine; Female; Humans; Infant, Newborn; Methadone; Methamphetamine; Pregnancy; Pregnancy Complicat

2021
Integration of a contraception clinic into an opioid treatment setting to improve contraception knowledge, accessibility and uptake: a pilot study.
    Australian and New Zealand journal of public health, 2020, Volume: 44, Issue:5

    Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Contraception; Delivery of Health Care, Integr

2020
Orchestrated Testing of Formula Type to Reduce Length of Stay in Neonatal Abstinence Syndrome.
    Pediatrics, 2020, Volume: 146, Issue:4

    Topics: Energy Intake; Female; Humans; Infant Formula; Infant, Newborn; Lactose; Length of Stay; Methadone;

2020
A mixed methods study exploring methadone treatment disclosure and perceptions of reproductive health care among women ages 18-44 years, Los Angeles, CA.
    Journal of substance abuse treatment, 2020, Volume: 118

    Topics: Adolescent; Adult; Disclosure; Female; Humans; Los Angeles; Methadone; Perception; Pregnancy; Qualit

2020
Contraception Practices Among Women on Opioid Agonist Therapy.
    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2021, Volume: 43, Issue:2

    Topics: Adult; British Columbia; Buprenorphine, Naloxone Drug Combination; Contraception; Contraception Beha

2021
Oxybutynin for methadone-induced sweating in pregnancy.
    Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists, 2021, Volume: 29, Issue:4

    Topics: Female; Humans; Mandelic Acids; Methadone; Pregnancy; Surveys and Questionnaires; Sweating

2021
Neurobehavior of newborn infants exposed prenatally to methadone and identification of a neurobehavioral profile linked to poorer neurodevelopmental outcomes at age 24 months.
    PloS one, 2020, Volume: 15, Issue:10

    Topics: Adult; Analgesics, Opioid; Attention; Case-Control Studies; Child Development; Female; Humans; Infan

2020
Methadone interrupts neural growth and function in human cortical organoids.
    Stem cell research, 2020, Volume: 49

    Topics: Action Potentials; Female; Humans; Infant, Newborn; Methadone; Organoids; Patch-Clamp Techniques; Pr

2020
Prevalence and Geographic Distribution of Obstetrician-Gynecologists Who Treat Medicaid Enrollees and Are Trained to Prescribe Buprenorphine.
    JAMA network open, 2020, 12-01, Volume: 3, Issue:12

    Topics: Adult; Buprenorphine; Cross-Sectional Studies; Female; Humans; Infant, Newborn; Male; Medicaid; Meth

2020
Is Maternal Methadone Dose Associated with the Severity of Neonatal Abstinence Syndrome?
    American journal of perinatology, 2022, Volume: 39, Issue:10

    Topics: Female; Humans; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome; Opioid-Related D

2022
Delivery dose of methadone, but not buprenorphine, is associated with the risk and severity of neonatal opiate withdrawal syndrome.
    American journal of obstetrics & gynecology MFM, 2020, Volume: 2, Issue:1

    Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Pregnancy; Pregnancy Complications; Prosp

2020
Neonatal abstinence syndrome in neonates born of mothers in drug-assisted rehabilitation.
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2021, 01-12, Volume: 141, Issue:1

    Topics: Female; Humans; Infant; Infant, Newborn; Methadone; Mothers; Neonatal Abstinence Syndrome; Norway; O

2021
Are point-of-care urine drug testing devices suitable for antenatal drug screening? A study verifying the Alere® Drug Screen Test Cup for the detection of six classes of drug in a pregnant population.
    Annals of clinical biochemistry, 2021, Volume: 58, Issue:3

    Topics: Amphetamine; Benzodiazepines; Buprenorphine; Chromatography, Liquid; Cocaine; Female; Gas Chromatogr

2021
Cost effectiveness of buprenorphine vs. methadone for pregnant people with opioid use disorder.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2022, Volume: 35, Issue:25

    Topics: Analgesics, Opioid; Buprenorphine; Cerebral Palsy; Cost-Benefit Analysis; Female; Fetal Growth Retar

2022
Prenatal methadone exposure and child developmental outcomes in 2-year-old children.
    Developmental medicine and child neurology, 2021, Volume: 63, Issue:9

    Topics: Adult; Child Development; Child, Preschool; Confounding Factors, Epidemiologic; Female; Humans; Infa

2021
Desire to avoid pregnancy and contraceptive use among female methadone patients in Los Angeles.
    Contraception, 2021, Volume: 103, Issue:5

    Topics: Contraception; Contraception Behavior; Contraceptive Agents; Female; Humans; Los Angeles; Methadone;

2021
Prenatal methadone exposure impairs adolescent cognition and GABAergic neurodevelopment in a novel rat model of maternal methadone treatment.
    Progress in neuro-psychopharmacology & biological psychiatry, 2021, 08-30, Volume: 110

    Topics: Analgesics, Opioid; Animals; Brain; Brain-Derived Neurotrophic Factor; Cognition; Disease Models, An

2021
Mental health and use of health care services in opioid-exposed school-aged children compared to foster children.
    European child & adolescent psychiatry, 2022, Volume: 31, Issue:3

    Topics: Analgesics, Opioid; Child; Child, Foster; Delivery of Health Care; Female; Foster Home Care; Humans;

2022
Prenatal methadone exposure disrupts behavioral development and alters motor neuron intrinsic properties and local circuitry.
    eLife, 2021, 03-16, Volume: 10

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Brain; Female; Humans; Male; Maternal Exposure; Metha

2021
Conceptualizing stigma in contexts of pregnancy and opioid misuse: A qualitative study with women and healthcare providers in Ohio.
    Drug and alcohol dependence, 2021, 05-01, Volume: 222

    Topics: Adult; Buprenorphine; Female; Health Personnel; Humans; Infant, Newborn; Methadone; Neonatal Abstine

2021
Leveraging Telehealth in the United States to Increase Access to Opioid Use Disorder Treatment in Pregnancy and Postpartum During the COVID-19 Pandemic.
    The American journal of psychiatry, 2021, 04-01, Volume: 178, Issue:4

    Topics: Adult; Buprenorphine; Comorbidity; Comprehensive Health Care; COVID-19; Delivery of Health Care; Evi

2021
Impact of opioid maintenance treatment during pregnancy on neonatal birth weight and head circumference.
    Journal of neonatal-perinatal medicine, 2021, Volume: 14, Issue:4

    Topics: Analgesics, Opioid; Birth Weight; Buprenorphine; Female; Humans; Infant; Infant, Newborn; Male; Meth

2021
Methadone and buprenorphine discontinuation among postpartum women with opioid use disorder.
    American journal of obstetrics and gynecology, 2021, Volume: 225, Issue:4

    Topics: Adult; Analgesics, Opioid; Black or African American; Buprenorphine; Correctional Facilities; Ethnic

2021
Outcomes associated with the use of medications for opioid use disorder during pregnancy.
    Addiction (Abingdon, England), 2021, Volume: 116, Issue:12

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant; Infant, Newborn; Methadone; Neonatal Abst

2021
Affective decision-making in children prenatally exposed to opioids.
    Scandinavian journal of psychology, 2021, Volume: 62, Issue:4

    Topics: Analgesics, Opioid; Buprenorphine; Child; Child Development; Cognition; Decision Making; Female; Hum

2021
Nail disease in neonatal abstinence syndrome.
    Pediatric dermatology, 2021, Volume: 38, Issue:4

    Topics: Female; Humans; Infant; Infant, Newborn; Male; Methadone; Nail Diseases; Neonatal Abstinence Syndrom

2021
Racial inequity in methadone dose at delivery in pregnant women with opioid use disorder.
    Journal of substance abuse treatment, 2021, Volume: 131

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-

2021
Can buprenorphine be used for opioid use disorder during pregnancy?
    JAAPA : official journal of the American Academy of Physician Assistants, 2021, Aug-01, Volume: 34, Issue:8

    Topics: Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; P

2021
Prenatal opioid administration induces shared alterations to the maternal and offspring gut microbiome: A preliminary analysis.
    Drug and alcohol dependence, 2021, 10-01, Volume: 227

    Topics: Analgesics, Opioid; Animals; Female; Gastrointestinal Microbiome; Male; Methadone; Mice; Pregnancy;

2021
Variations in Infant CYP2B6 Genotype Associated with the Need for Pharmacological Treatment for Neonatal Abstinence Syndrome in Infants of Methadone-Maintained Opioid-Dependent Mothers.
    American journal of perinatology, 2017, Volume: 34, Issue:9

    Topics: Adult; Analgesics, Opioid; Cohort Studies; Cytochrome P-450 CYP2B6; Female; Genetic Variation; Human

2017
Infants Born to Opioid-Dependent Women in Ontario, 2002-2014.
    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2017, Volume: 39, Issue:3

    Topics: Adult; Buprenorphine; Congenital Abnormalities; Databases, Factual; Female; Health Care Costs; Human

2017
A Retrospective Cohort Study of Birth Outcomes in Neonates Exposed to Naltrexone in Utero: A Comparison with Methadone-, Buprenorphine- and Non-opioid-Exposed Neonates.
    Drugs, 2017, Volume: 77, Issue:11

    Topics: Adult; Australia; Buprenorphine; Drug Administration Routes; Female; Humans; Incidence; Infant, Newb

2017
An Initiative to Improve the Quality of Care of Infants With Neonatal Abstinence Syndrome.
    Pediatrics, 2017, Volume: 139, Issue:6

    Topics: Female; Hospital Costs; Humans; Infant, Newborn; Length of Stay; Male; Methadone; Morphine; Narcotic

2017
Characteristics and Outcome of Male and Female Methadone Maintenance Patients: MMT in Tel Aviv and Las Vegas.
    Substance use & misuse, 2018, 01-28, Volume: 53, Issue:2

    Topics: Adult; Age Factors; Analgesics, Opioid; Benzodiazepines; Cocaine; Female; Humans; Israel; Male; Meth

2018
Hepatitis C Cascade of Care Among Pregnant Women on Opioid Agonist Pharmacotherapy Attending a Comprehensive Prenatal Program.
    Maternal and child health journal, 2017, Volume: 21, Issue:9

    Topics: Adult; Analgesics, Opioid; Female; Hepacivirus; Hepatitis C; Humans; Mass Screening; Methadone; Mexi

2017
Sensorimotor outcomes in children with prenatal exposure to methadone.
    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2017, Volume: 21, Issue:4

    Topics: Age of Onset; Exotropia; Female; Humans; Infant; Methadone; Narcotics; Neonatal Abstinence Syndrome;

2017
Association of methadone dose with substance use and treatment retention in pregnant and postpartum women with opioid use disorder.
    Journal of substance abuse treatment, 2017, Volume: 80

    Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Humans; Methadone; Opiate Subst

2017
Transitioning from methadone to buprenorphine maintenance in management of opioid use disorder during pregnancy.
    The American journal of drug and alcohol abuse, 2018, Volume: 44, Issue:3

    Topics: Adult; Analgesics, Opioid; Buprenorphine; Drug Substitution; Female; Humans; Infant, Newborn; Methad

2018
Increased DNA Methylation of ABCB1, CYP2D6, and OPRM1 Genes in Newborn Infants of Methadone-Maintained Opioid-Dependent Mothers.
    The Journal of pediatrics, 2017, Volume: 190

    Topics: Adult; Analgesics, Opioid; ATP Binding Cassette Transporter, Subfamily B; Case-Control Studies; Coho

2017
Maternal buprenorphine treatment and infant outcome.
    Drug and alcohol dependence, 2017, 11-01, Volume: 180

    Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Opiate Subs

2017
Antenatal methadone vs buprenorphine exposure and length of hospital stay in infants admitted to the intensive care unit with neonatal abstinence syndrome.
    Journal of perinatology : official journal of the California Perinatal Association, 2018, Volume: 38, Issue:1

    Topics: Adult; Buprenorphine; Female; Gestational Age; Humans; Infant, Newborn; Intensive Care Units, Neonat

2018
Methadone Versus Buprenorphine for Opioid Use Dependence and Risk of Neonatal Abstinence Syndrome.
    Epidemiology (Cambridge, Mass.), 2018, Volume: 29, Issue:2

    Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Absti

2018
Medicaid Coverage of Methadone Maintenance and the Use of Opioid Agonist Therapy Among Pregnant Women in Specialty Treatment.
    Medical care, 2017, Volume: 55, Issue:12

    Topics: Adult; Cross-Sectional Studies; Eligibility Determination; Female; Health Services Accessibility; Hu

2017
A retrospective cohort study of the health of children prenatally exposed to methadone, buprenorphine or naltrexone compared with non-exposed control children.
    The American journal on addictions, 2017, Volume: 26, Issue:8

    Topics: Adult; Buprenorphine; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Longitudinal

2017
Invited Commentary: A Novel Strategy for Addressing Unmeasured Confounding When Comparing Opioid Agonist Therapies in Pregnancy.
    American journal of epidemiology, 2018, 06-01, Volume: 187, Issue:6

    Topics: Buprenorphine; Female; Humans; Infant, Newborn; Medicaid; Methadone; Opiate Substitution Treatment;

2018
Neonatal Outcomes in a Medicaid Population With Opioid Dependence.
    American journal of epidemiology, 2018, 06-01, Volume: 187, Issue:6

    Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Narcotics; Opioid-Related Disorders; Preg

2018
Early inhibitory control and working memory abilities of children prenatally exposed to methadone.
    Early human development, 2018, Volume: 116

    Topics: Adult; Behavioral Symptoms; Case-Control Studies; Child, Preschool; Executive Function; Female; Huma

2018
Use of Marijuana and Other Substances Among Pregnant and Parenting Women With Substance Use Disorders: Changes in Washington State After Marijuana Legalization.
    Journal of studies on alcohol and drugs, 2018, Volume: 79, Issue:1

    Topics: Adult; Amphetamines; Female; Humans; Legislation, Drug; Marijuana Abuse; Marijuana Smoking; Methadon

2018
Prenatal methadone exposure is associated with altered neonatal brain development.
    NeuroImage. Clinical, 2018, Volume: 18

    Topics: Brain; Child; Child Development; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging; Fem

2018
The Role of Preterm Birth in the Association Between Opioid Maintenance Therapy and Neonatal Abstinence Syndrome.
    Paediatric and perinatal epidemiology, 2018, Volume: 32, Issue:2

    Topics: Adult; Buprenorphine; Female; Humans; Infant, Newborn; Maternal Age; Methadone; Neonatal Abstinence

2018
Neonatal outcomes after fetal exposure to methadone and buprenorphine: national registry studies from the Czech Republic and Norway.
    Addiction (Abingdon, England), 2018, Volume: 113, Issue:7

    Topics: Abortion, Spontaneous; Adult; Analgesics, Opioid; Apgar Score; Buprenorphine; Czech Republic; Female

2018
Treating women with opioid use disorder during pregnancy in Appalachia: Initial neonatal outcomes following buprenorphine + naloxone exposure.
    The American journal on addictions, 2018, Volume: 27, Issue:2

    Topics: Adult; Appalachian Region; Birth Weight; Buprenorphine, Naloxone Drug Combination; Female; Humans; I

2018
Pregnancy and the Opioid Epidemic.
    Journal of psychosocial nursing and mental health services, 2018, Mar-01, Volume: 56, Issue:3

    Topics: Analgesics, Opioid; Epidemics; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndr

2018
Opioid Utilization by Pregnant Women with Sickle Cell Disease and the Risk of Neonatal Abstinence Syndrome.
    Journal of the National Medical Association, 2018, Volume: 110, Issue:2

    Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Case-Control Studies; Female; Humans; Incidence; Met

2018
Barriers and Facilitators of Breastfeeding Reported by Postpartum Women in Methadone Maintenance Therapy.
    Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, 2018, Volume: 13, Issue:4

    Topics: Adolescent; Adult; Breast Feeding; Cross-Sectional Studies; Female; Humans; Infant; Infant Nutrition

2018
Quality improvement initiative to improve inpatient outcomes for Neonatal Abstinence Syndrome.
    Journal of perinatology : official journal of the California Perinatal Association, 2018, Volume: 38, Issue:8

    Topics: Adult; Female; Hospital Costs; Humans; Infant, Newborn; Inpatients; Length of Stay; Male; Methadone;

2018
Early Treatment Innovation for Opioid-Dependent Newborns: A Retrospective Comparison of Outcomes, Utilization, Quality, and Safety, 2006-2014.
    Joint Commission journal on quality and patient safety, 2018, Volume: 44, Issue:6

    Topics: Child Protective Services; Community Health Services; Continuity of Patient Care; Cooperative Behavi

2018
Barriers to accessing treatment for pregnant women with opioid use disorder in Appalachian states.
    Substance abuse, 2019, Volume: 40, Issue:3

    Topics: Analgesics, Opioid; Appalachian Region; Buprenorphine; Female; Health Expenditures; Health Personnel

2019
ERP correlates of cognitive control in children prenatally exposed to methadone or buprenorphine.
    Developmental neuropsychology, 2018, Volume: 43, Issue:7

    Topics: Buprenorphine; Child; Cognition; Evoked Potentials; Female; Humans; Longitudinal Studies; Male; Meth

2018
Fatal and Nonfatal Overdose Among Pregnant and Postpartum Women in Massachusetts.
    Obstetrics and gynecology, 2018, Volume: 132, Issue:2

    Topics: Adult; Buprenorphine; Drug Overdose; Female; Humans; Massachusetts; Methadone; Opiate Substitution T

2018
Trends and Outcomes Associated With Using Long-Acting Opioids During Delivery Hospitalizations.
    Obstetrics and gynecology, 2018, Volume: 132, Issue:4

    Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Delivery, Obstetric; Female; Guideline Adheren

2018
Prenatal Treatment and Outcomes of Women With Opioid Use Disorder.
    Obstetrics and gynecology, 2018, Volume: 132, Issue:4

    Topics: Adult; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disor

2018
Impact of psychiatric medication co-exposure on Neonatal Abstinence Syndrome severity.
    Drug and alcohol dependence, 2018, 11-01, Volume: 192

    Topics: Adult; Analgesics, Opioid; Benzodiazepines; Buprenorphine; Female; Gabapentin; Humans; Infant; Infan

2018
Buprenorphine medication-assisted treatment during pregnancy: An exploratory factor analysis associated with adherence.
    Drug and alcohol dependence, 2018, 11-01, Volume: 192

    Topics: Adult; Buprenorphine; Factor Analysis, Statistical; Female; Humans; Infant, Newborn; Medication Adhe

2018
Impact of timing of methadone initiation on perinatal outcomes following delivery among pregnant women on methadone maintenance therapy in Ontario.
    Addiction (Abingdon, England), 2019, Volume: 114, Issue:2

    Topics: Adolescent; Adult; Analgesics, Opioid; Drug Administration Schedule; Female; Humans; Methadone; Midd

2019
Relationship Between Methadone, Selective Serotonin Reuptake Inhibitors, and Neonatal Abstinence Syndrome.
    The Journal of reproductive medicine, 2016, Volume: 61, Issue:9-10

    Topics: Adult; Cohort Studies; Female; Humans; Infant, Newborn; Intensive Care Units, Neonatal; Length of St

2016
Novel Withdrawal Symptoms of a Neonate Prenatally Exposed to a Fentanyl Analog.
    Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners, 2019, Volume: 33, Issue:1

    Topics: Anticonvulsants; Clonidine; Female; Fentanyl; Humans; Infant, Newborn; Levetiracetam; Methadone; Myo

2019
Could prenatal food insecurity influence neonatal abstinence syndrome severity?
    Addiction (Abingdon, England), 2019, Volume: 114, Issue:2

    Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Food Supply; Humans; Methadone; Neonatal Abstinenc

2019
Children exposed to maternal methadone treatment prenatally are at risk of abnormal neurodevelopment.
    Developmental medicine and child neurology, 2019, Volume: 61, Issue:7

    Topics: Child; Female; Humans; Methadone; Pregnancy; Prenatal Exposure Delayed Effects

2019
Integrated Brief Intervention for PTSD and Substance Use in an Antepartum Unit.
    Maternal and child health journal, 2019, Volume: 23, Issue:5

    Topics: Adaptation, Psychological; Adult; Alcoholism; Benzodiazepines; Buprenorphine; Female; Humans; Matern

2019
Coordinating Outpatient Care for Pregnant and Postpartum Women with Opioid Use Disorder: Implications from the COACHH Program.
    Maternal and child health journal, 2019, Volume: 23, Issue:5

    Topics: Adult; Ambulatory Care; Analgesics, Opioid; Female; Humans; Interviews as Topic; Massachusetts; Meth

2019
Best Practices for Pregnant Incarcerated Women With Opioid Use Disorder.
    Journal of correctional health care : the official journal of the National Commission on Correctional Health Care, 2019, Volume: 25, Issue:1

    Topics: Buprenorphine; Female; Humans; Methadone; Narcotics; Opiate Substitution Treatment; Opioid-Related D

2019
Medical specialty of buprenorphine prescribers for pregnant women with opioid use disorder.
    American journal of obstetrics and gynecology, 2019, Volume: 220, Issue:5

    Topics: Analgesics, Opioid; Buprenorphine; Drug Prescriptions; Female; Humans; Medicaid; Methadone; Opiate S

2019
Hospitalization of children after prenatal exposure to opioid maintenance therapy during pregnancy: a national registry study from the Czech Republic.
    Addiction (Abingdon, England), 2019, Volume: 114, Issue:7

    Topics: Adult; Analgesics, Opioid; Buprenorphine; Case-Control Studies; Child, Preschool; Czech Republic; Di

2019
Inadequate prenatal care utilization among women with and without methadone-treated opioid use disorders in Taiwan.
    The International journal on drug policy, 2019, Volume: 67

    Topics: Adult; Case-Control Studies; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Relate

2019
Prescription Drug and Alcohol Use Disorders: Opioid Use Disorder.
    FP essentials, 2019, Volume: 478

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Naltrexone; Opiate Substitution Treatm

2019
Implications of perinatal buprenorphine exposure on infant head circumference at birth.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2021, Volume: 34, Issue:2

    Topics: Buprenorphine; Female; Humans; Infant; Infant, Newborn; Male; Methadone; Neonatal Abstinence Syndrom

2021
Medication-Assisted Treatment Use Among Pregnant Women With Opioid Use Disorder.
    Obstetrics and gynecology, 2019, Volume: 133, Issue:5

    Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Cohort Studies; Databases, Factual; Female; Hu

2019
Factors associated with treatment retention in pregnant women with opioid use disorders prescribed methadone or electing non-pharmacological treatment.
    Women & health, 2020, Volume: 60, Issue:1

    Topics: Adult; Baltimore; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders

2020
Placental trophoblast transfer of opioids following exposures to individual or mixtures of opioids
    Experimental biology and medicine (Maywood, N.J.), 2019, Volume: 244, Issue:10

    Topics: Analgesics, Opioid; Female; Fentanyl; Gas Chromatography-Mass Spectrometry; Heroin; Humans; Maternal

2019
Methadone, Pierre Robin sequence and other congenital anomalies: case-control study.
    Archives of disease in childhood. Fetal and neonatal edition, 2020, Volume: 105, Issue:2

    Topics: Adult; Case-Control Studies; Cleft Palate; Comorbidity; Europe; Female; Gestational Age; Humans; Inf

2020
Interventions for the Treatment of Neonatal Abstinence Syndrome.
    Nursing for women's health, 2019, Volume: 23, Issue:4

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Male; Methadone; Morphine; Neona

2019
Opioid receptor-mediated changes in the NMDA receptor in developing rat and chicken.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2019, Volume: 78

    Topics: Analgesics, Opioid; Animals; Buprenorphine; Cerebellum; Chickens; Female; Methadone; Morphine; Pregn

2019
Treating perinatal opioid use disorder in rural settings: Challenges and opportunities.
    Preventive medicine, 2019, Volume: 128

    Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; New Hampshire; Opiate Substitut

2019
High Accumulation of Methadone Compared with Buprenorphine in Fetal Rat Brain after Maternal Exposure.
    The Journal of pharmacology and experimental therapeutics, 2019, Volume: 371, Issue:1

    Topics: Analgesics, Opioid; Animals; Body Weight; Brain; Buprenorphine; Female; Fetus; Male; Maternal-Fetal

2019
Prevalence of Maternal-Risk Factors Related to Neonatal Abstinence Syndrome in a Commercial Claims Database: 2011-2015.
    Pharmacotherapy, 2019, Volume: 39, Issue:10

    Topics: Adult; Analgesics, Opioid; Drug Prescriptions; Female; Humans; Incidence; Infant, Newborn; Insurance

2019
Evaluation of a Nurse-Led Program for Rural Pregnant Women With Opioid Use Disorder to Improve Maternal-Neonatal Outcomes.
    Journal of obstetric, gynecologic, and neonatal nursing : JOGNN, 2019, Volume: 48, Issue:5

    Topics: Adult; Buprenorphine; Databases, Factual; Female; Hospitals, Community; Humans; Infant Health; Massa

2019
Use of naltrexone in treating opioid use disorder in pregnancy.
    American journal of obstetrics and gynecology, 2020, Volume: 222, Issue:1

    Topics: Abortion, Spontaneous; Adult; Analgesics, Opioid; Buprenorphine; Case-Control Studies; Female; Human

2020
Neonatal visual evoked potentials in infants born to mothers prescribed methadone.
    Pediatrics, 2013, Volume: 131, Issue:3

    Topics: Cohort Studies; Evoked Potentials, Visual; Female; Humans; Infant, Newborn; Male; Methadone; Pilot P

2013
Predictors of neonatal outcomes amongst a methadone- and/or heroin-dependent population referred to a multidisciplinary Perinatal and Family Drug Health Service.
    The Australian & New Zealand journal of obstetrics & gynaecology, 2013, Volume: 53, Issue:5

    Topics: Adult; Child Custody; Female; Gestational Age; Heroin Dependence; Humans; Infant, Low Birth Weight;

2013
Development of sensitization to methamphetamine in offspring prenatally exposed to morphine, methadone and buprenorphine.
    Addiction biology, 2014, Volume: 19, Issue:4

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Buprenorphine; Central Nervous System Stimulants; Fem

2014
Treating opioid use disorders during pregnancy: historical, current, and future directions.
    Substance abuse, 2013, Volume: 34, Issue:2

    Topics: Buprenorphine; Disease Management; Female; History, 19th Century; History, 20th Century; History, 21

2013
Trends in the average prescribed dose of methadone: more than a proxy for the evolution of severity of opioid dependence.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2013, Volume: 33, Issue:4

    Topics: Female; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy; Pregnancy Complications

2013
Re: Letter from J. Trujols, N. Siñol & J. Pérez De Los Cobos.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2013, Volume: 33, Issue:4

    Topics: Female; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy; Pregnancy Complications

2013
Substance, structure and stigma: parents in the UK accounting for opioid substitution therapy during the antenatal and postnatal periods.
    The International journal on drug policy, 2013, Volume: 24, Issue:6

    Topics: Adult; Analgesics, Opioid; Drug Users; Family Relations; Female; Humans; Interviews as Topic; Longit

2013
The obstetrical and neonatal impact of maternal opioid detoxification in pregnancy.
    American journal of obstetrics and gynecology, 2013, Volume: 209, Issue:3

    Topics: Adult; Cohort Studies; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Opi

2013
Deviant smooth pursuit in preschool children exposed prenatally to methadone or buprenorphine and tobacco affects integrative visuomotor capabilities.
    Addiction (Abingdon, England), 2013, Volume: 108, Issue:12

    Topics: Analysis of Variance; Buprenorphine; Child, Preschool; Cohort Studies; Female; Humans; Male; Methado

2013
Congenital nystagmus in two infants born from mothers exposed to methadone during pregnancy.
    Italian journal of pediatrics, 2013, Jul-03, Volume: 39

    Topics: Female; Humans; Infant; Infant, Newborn; Maternal Exposure; Methadone; Narcotics; Nystagmus, Congeni

2013
Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19.
    British journal of clinical pharmacology, 2014, Volume: 77, Issue:3

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Computer Simulation; Cytochrome P-450 CYP

2014
In utero drug and alcohol exposure in infants born to mothers prescribed maintenance methadone.
    Archives of disease in childhood. Fetal and neonatal edition, 2013, Volume: 98, Issue:6

    Topics: Analgesics, Opioid; Central Nervous System Depressants; Ethanol; Female; Humans; Illicit Drugs; Infa

2013
Alternative matrices for cocaine, heroin, and methadone in utero drug exposure detection.
    Therapeutic drug monitoring, 2013, Volume: 35, Issue:4

    Topics: Chromatography, Liquid; Cocaine; Drug Monitoring; Female; Hair; Heroin; Humans; Maternal-Fetal Excha

2013
Response to Chandler et al., Substance, structure and stigma: parents in the UK accounting for opioid substitution therapy during the antenatal and postnatal periods.
    The International journal on drug policy, 2013, Volume: 24, Issue:6

    Topics: Analgesics, Opioid; Drug Users; Female; Humans; Male; Methadone; Opiate Substitution Treatment; Opio

2013
Maternal stress and behavioral adaptation in methadone- or buprenorphine-exposed toddlers.
    Infant behavior & development, 2013, Volume: 36, Issue:4

    Topics: Adult; Anxiety; Buprenorphine; Child; Child, Preschool; Depression; Family; Female; Humans; Longitud

2013
Development of auditory event-related potentials in infants prenatally exposed to methadone.
    Developmental psychobiology, 2014, Volume: 56, Issue:5

    Topics: Acoustic Stimulation; Adult; Auditory Cortex; Electroencephalography; Evoked Potentials, Auditory; F

2014
Social determinants of methadone in pregnancy: violence, social capital, and mental health.
    Issues in mental health nursing, 2013, Volume: 34, Issue:10

    Topics: Domestic Violence; Female; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy; Risk F

2013
Clinical care for opioid-using pregnant and postpartum women: the role of obstetric providers.
    American journal of obstetrics and gynecology, 2014, Volume: 210, Issue:4

    Topics: Analgesics, Opioid; Buprenorphine; Confidentiality; Dose-Response Relationship, Drug; Emergency Serv

2014
Integrated care for pregnant women on methadone maintenance treatment: Canadian primary care cohort study.
    Canadian family physician Medecin de famille canadien, 2013, Volume: 59, Issue:10

    Topics: Adolescent; Adult; Analgesics, Opioid; Canada; Cohort Studies; Delivery of Health Care, Integrated;

2013
Effectiveness of a clinical pathway with methadone treatment protocol for treatment of neonatal abstinence syndrome following in utero drug exposure to substances of abuse*.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2014, Volume: 15, Issue:2

    Topics: Analgesics, Opioid; Clinical Protocols; Female; Humans; Infant, Newborn; Intensive Care Units, Neona

2014
Effect of prenatal methadone on reinstated behavioral sensitization induced by methamphetamine in adolescent rats.
    Behavioural brain research, 2014, Jan-01, Volume: 258

    Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Female; Methadone; Methamphetamine; Mo

2014
Reply: To PMID 23727040.
    American journal of obstetrics and gynecology, 2014, Volume: 210, Issue:4

    Topics: Female; Humans; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Complications

2014
The obstetric and neonatal impact of maternal opioid detoxification in pregnancy.
    American journal of obstetrics and gynecology, 2014, Volume: 210, Issue:4

    Topics: Female; Humans; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Complications

2014
Visual outcome in infants born to drug-misusing mothers prescribed methadone in pregnancy.
    The British journal of ophthalmology, 2014, Volume: 98, Issue:2

    Topics: Evoked Potentials, Visual; Eye Diseases; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn;

2014
Rates of fetal polydrug exposures in methadone-maintained pregnancies from a high-risk population.
    PloS one, 2013, Volume: 8, Issue:12

    Topics: Adult; Cocaine; Female; Humans; Infant, Newborn; Meconium; Methadone; Opiate Substitution Treatment;

2013
Reduced fetal growth in methadone-maintained pregnancies is not fully explained by smoking or socio-economic deprivation.
    Addiction (Abingdon, England), 2014, Volume: 109, Issue:3

    Topics: Adult; Analgesics, Opioid; Birth Weight; Cohort Studies; Female; Fetal Growth Retardation; Head; Hum

2014
Searching the right way to treat neonatal abstinence syndrome*.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2014, Volume: 15, Issue:2

    Topics: Analgesics, Opioid; Female; Humans; Male; Methadone; Neonatal Abstinence Syndrome; Pregnancy; Pregna

2014
Commentary on Mactier et al. (2014): Methadone-assisted treatment and the complexity of influences on fetal development.
    Addiction (Abingdon, England), 2014, Volume: 109, Issue:3

    Topics: Analgesics, Opioid; Birth Weight; Female; Fetal Growth Retardation; Humans; Male; Methadone; Opioid-

2014
Use of hair testing to determine methadone exposure in pediatric deaths.
    Journal of forensic sciences, 2014, Volume: 59, Issue:5

    Topics: Breast Feeding; Child of Impaired Parents; Female; Forensic Toxicology; Hair; Humans; Infant; Male;

2014
Breastfeeding and Methadone Therapy: The Maternal Experience.
    Substance abuse, 2015, Volume: 36, Issue:2

    Topics: Adolescent; Adult; Analgesics, Opioid; Breast Feeding; Contraindications; Female; Focus Groups; Heal

2015
Postpartum changes in methadone maintenance dose.
    Journal of substance abuse treatment, 2014, Volume: 47, Issue:3

    Topics: Adult; Benzodiazepines; Cohort Studies; Female; Humans; Methadone; Narcotics; Opiate Substitution Tr

2014
Neonatal abstinence syndrome: on the evidence to add breastfeeding to any clinical pathway.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2014, Volume: 15, Issue:6

    Topics: Analgesics, Opioid; Female; Humans; Male; Methadone; Neonatal Abstinence Syndrome; Pregnancy; Pregna

2014
The authors reply.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2014, Volume: 15, Issue:6

    Topics: Analgesics, Opioid; Female; Humans; Male; Methadone; Neonatal Abstinence Syndrome; Pregnancy; Pregna

2014
Characteristics and quality of life of opioid-dependent pregnant women in Austria.
    Archives of women's mental health, 2014, Volume: 17, Issue:6

    Topics: Administration, Oral; Adult; Austria; Buprenorphine; Delayed-Action Preparations; Female; Humans; Me

2014
The opioid system and brain development: effects of methadone on the oligodendrocyte lineage and the early stages of myelination.
    Developmental neuroscience, 2014, Volume: 36, Issue:5

    Topics: Animals; Axons; Brain; Cell Lineage; Cell Proliferation; Female; Methadone; Myelin Basic Protein; My

2014
Comparison of adverse obstetric outcomes and maternity hospitalization among heroin-exposed and methadone-treated women in Taiwan.
    The International journal on drug policy, 2015, Volume: 26, Issue:2

    Topics: Adult; Cohort Studies; Female; Heroin Dependence; Hospitalization; Humans; Length of Stay; Methadone

2015
Identification of early developmental deficits in infants with prenatal heroin, methadone, and other opioid exposure.
    Clinical pediatrics, 2015, Volume: 54, Issue:4

    Topics: Analgesics, Opioid; Child Development; Developmental Disabilities; Female; Heroin; Humans; Infant; I

2015
Executive function in preschool children prenatally exposed to methadone or buprenorphine.
    Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence, 2015, Volume: 21, Issue:5

    Topics: Analgesics, Opioid; Buprenorphine; Case-Control Studies; Child; Child Development; Child, Preschool;

2015
Visual selective attention is impaired in children prenatally exposed to opioid agonist medication.
    European addiction research, 2015, Volume: 21, Issue:2

    Topics: Analgesics, Opioid; Attention; Buprenorphine; Case-Control Studies; Child, Preschool; Female; Humans

2015
Contribution of in utero drug exposure when interpreting hair results in young children.
    Forensic science international, 2015, Volume: 249

    Topics: Amitriptyline; Bromazepam; Cannabinoids; Diazepam; Diphenhydramine; Female; Forensic Toxicology; Hai

2015
Infants of opioid-dependent mothers: neurodevelopment at six months.
    Early human development, 2015, Volume: 91, Issue:1

    Topics: Adult; Analgesics, Opioid; Case-Control Studies; Child Development; Female; Humans; Infant; Infant,

2015
Management of neonatal abstinence syndrome in the newborn nursery.
    Nursing for women's health, 2014, Volume: 18, Issue:6

    Topics: Female; Humans; Infant, Newborn; Methadone; Mother-Child Relations; Neonatal Abstinence Syndrome; Pr

2014
Buprenorphine and naloxone compared with methadone treatment in pregnancy.
    Obstetrics and gynecology, 2015, Volume: 125, Issue:2

    Topics: Adult; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naloxone; Narcotic Antagonists; Na

2015
Buprenorphine and naloxone compared with methadone treatment in pregnancy.
    Obstetrics and gynecology, 2015, Volume: 125, Issue:2

    Topics: Adult; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naloxone; Narcotic Antagonists; Na

2015
Buprenorphine and naloxone compared with methadone treatment in pregnancy.
    Obstetrics and gynecology, 2015, Volume: 125, Issue:2

    Topics: Adult; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naloxone; Narcotic Antagonists; Na

2015
Buprenorphine and naloxone compared with methadone treatment in pregnancy.
    Obstetrics and gynecology, 2015, Volume: 125, Issue:2

    Topics: Adult; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naloxone; Narcotic Antagonists; Na

2015
Maternal Substance Use and Neonatal Abstinence Syndrome: A Descriptive Study.
    Maternal and child health journal, 2015, Volume: 19, Issue:8

    Topics: Adolescent; Adult; Female; Humans; Infant, Newborn; Length of Stay; Methadone; Mothers; Neonatal Abs

2015
First Dutch national guidelines--pharmacological care for detained opioid addicts.
    International journal of prisoner health, 2009, Volume: 5, Issue:4

    Topics: Buprenorphine; Communicable Diseases; Comorbidity; Continuity of Patient Care; Female; Health Policy

2009
Caring for Opioid-dependent Pregnant Women: Prenatal and Postpartum Care Considerations.
    Clinical obstetrics and gynecology, 2015, Volume: 58, Issue:2

    Topics: Alcohol-Related Disorders; Breast Feeding; Counseling; Female; Humans; Incidence; Infant, Newborn; M

2015
UHPLC-MS/MS quantification of buprenorphine, norbuprenorphine, methadone, and glucuronide conjugates in umbilical cord plasma.
    Biomedical chromatography : BMC, 2015, Volume: 29, Issue:10

    Topics: Blood Chemical Analysis; Blood Specimen Collection; Buprenorphine; Chromatography, High Pressure Liq

2015
Growth and developmental outcome of infants with in-utero exposure to methadone vs buprenorphine.
    Journal of perinatology : official journal of the California Perinatal Association, 2015, Volume: 35, Issue:8

    Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Infant; Infant, Newborn; Infant, Premature

2015
Beneficial effects of co-treatment with dextromethorphan on prenatally methadone-exposed offspring.
    Journal of biomedical science, 2015, Mar-20, Volume: 22

    Topics: Animals; Antitussive Agents; Dextromethorphan; Female; Male; Methadone; Morphine Dependence; Narcoti

2015
Maternal methadone treatment and neonatal abstinence syndrome.
    American journal of perinatology, 2015, Volume: 32, Issue:11

    Topics: Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Length of Stay; Logistic Models

2015
Tapering from Methadone or Buprenorphine during Pregnancy: Maternal and Neonatal Outcomes in Norway 1996-2009.
    European addiction research, 2015, Volume: 21, Issue:5

    Topics: Adult; Birth Weight; Buprenorphine; Drug Administration Schedule; Female; Humans; Infant, Newborn; M

2015
Exposure to prescription opioid analgesics in utero and risk of neonatal abstinence syndrome: population based cohort study.
    BMJ (Clinical research ed.), 2015, May-14, Volume: 350

    Topics: Adolescent; Adult; Analgesics, Opioid; Cohort Studies; Dose-Response Relationship, Drug; Female; Hum

2015
Obstetrical and neonatal outcomes of methadone-maintained pregnant women: a canadian multisite cohort study.
    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2015, Volume: 37, Issue:3

    Topics: Adult; Birth Weight; Breast Feeding; Canada; Female; Gestational Age; Humans; Infant, Newborn; Lengt

2015
Maternal use of methadone and risk of sudden neonatal death.
    Acta paediatrica (Oslo, Norway : 1992), 2015, Volume: 104, Issue:9

    Topics: Adult; Female; Humans; Infant, Newborn; Male; Methadone; Narcotics; Opioid-Related Disorders; Perina

2015
Methadone versus buprenorphine for the treatment of opioid abuse in pregnancy: science and stigma.
    The American journal of drug and alcohol abuse, 2015, Volume: 41, Issue:5

    Topics: Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; P

2015
Opioid use disorder during pregnancy in Tennessee: expediency vs. science.
    The American journal of drug and alcohol abuse, 2015, Volume: 41, Issue:5

    Topics: Buprenorphine; Female; Humans; Insurance Coverage; Medicaid; Methadone; Opiate Substitution Treatmen

2015
Caring for pregnant opioid abusers in Vermont: A potential model for non-urban areas.
    Preventive medicine, 2015, Volume: 80

    Topics: Adult; Buprenorphine; Community Health Centers; Female; Health Services Accessibility; Humans; Infan

2015
Neonatal abstinence syndrome: Historical perspective, current focus, future directions.
    Preventive medicine, 2015, Volume: 80

    Topics: Adult; Analgesics, Opioid; Female; History, 19th Century; History, 20th Century; History, 21st Centu

2015
Cohort Analysis of a Pharmacokinetic-Modeled Methadone Weaning Optimization for Neonatal Abstinence Syndrome.
    The Journal of pediatrics, 2015, Volume: 167, Issue:6

    Topics: Adult; Analgesics, Opioid; Cohort Studies; Female; Humans; Infant, Newborn; Length of Stay; Male; Me

2015
Revision of Breastfeeding Guidelines in the Setting of Maternal Opioid Use Disorder: One Institution's Experience.
    Journal of human lactation : official journal of International Lactation Consultant Association, 2016, Volume: 32, Issue:2

    Topics: Analgesics, Opioid; Boston; Breast Feeding; Buprenorphine; Female; Health Promotion; Humans; Infant,

2016
Retrospective chart review comparing morphine and methadone in neonates treated for neonatal abstinence syndrome.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2015, Dec-01, Volume: 72, Issue:23 Suppl 3

    Topics: Administration, Oral; Analgesics, Opioid; Female; Humans; Infant, Newborn; Male; Methadone; Morphine

2015
Rooming-in for Infants at Risk of Neonatal Abstinence Syndrome.
    American journal of perinatology, 2016, Volume: 33, Issue:5

    Topics: Adult; Analgesics, Opioid; Bottle Feeding; Breast Feeding; Canada; Female; Humans; Infant, Newborn;

2016
US pledges better protection for babies born to addicts.
    BMJ (Clinical research ed.), 2016, Mar-22, Volume: 352

    Topics: Adult; Child of Impaired Parents; Child Protective Services; Female; Heroin Dependence; Humans; Infa

2016
ADHD risk alleles associated with opiate addiction: study of addicted parents and their children.
    Pediatric research, 2016, Volume: 80, Issue:2

    Topics: Adolescent; Alleles; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Female;

2016
Simultaneous quantification of buprenorphine, naloxone and phase I and II metabolites in plasma and breastmilk by liquid chromatography-tandem mass spectrometry.
    Journal of chromatography. A, 2016, May-13, Volume: 1446

    Topics: Buprenorphine; Chromatography, Liquid; Female; Glucuronides; Humans; Infant, Newborn; Metabolic Deto

2016
Evaluation of the vaginal flora in pregnant women receiving opioid maintenance therapy: a matched case-control study.
    BMC pregnancy and childbirth, 2016, 08-05, Volume: 16, Issue:1

    Topics: Adult; Analgesics, Opioid; Asymptomatic Infections; Austria; Birth Weight; Buprenorphine; Candidiasi

2016
Opioid detoxification during pregnancy: the door continues to open.
    American journal of obstetrics and gynecology, 2016, Volume: 215, Issue:3

    Topics: Analgesics, Opioid; Female; Humans; Methadone; Narcotic Antagonists; Opioid-Related Disorders; Pregn

2016
Bioanalysis for cocaine, opiates, methadone, and amphetamines exposure detection during pregnancy.
    Drug testing and analysis, 2017, Volume: 9, Issue:6

    Topics: Amphetamines; Analgesics, Opioid; Anesthetics, Local; Central Nervous System Stimulants; Cocaine; Fe

2017
Mother-child interaction and cognitive development in children prenatally exposed to methadone or buprenorphine.
    Early human development, 2016, Volume: 101

    Topics: Adult; Buprenorphine; Case-Control Studies; Child Development; Cognition; Female; Humans; Infant, Ne

2016
Characteristics of Maternal-Infant Interaction During Treatment for Opioid Withdrawal.
    Neonatal network : NN, 2016, Volume: 35, Issue:5

    Topics: Adolescent; Adult; Bottle Feeding; Case-Control Studies; Female; Humans; Infant, Newborn; Male; Meth

2016
Neonatal Abstinence Syndrome: Twelve Years of Experience at a Regional Referral Center.
    Klinische Padiatrie, 2017, Volume: 229, Issue:1

    Topics: Buprenorphine; Diseases in Twins; Female; Hospitalization; Humans; Infant, Newborn; Male; Methadone;

2017
Neonatal abstinence syndrome and the gastrointestinal tract.
    Medical hypotheses, 2016, Volume: 97

    Topics: Analgesics, Opioid; Buprenorphine; Child; Child, Preschool; Dysbiosis; Female; Gastrointestinal Trac

2016
The relationship between gestational age and the severity of neonatal abstinence syndrome.
    Addiction (Abingdon, England), 2017, Volume: 112, Issue:4

    Topics: Adult; Analgesics, Opioid; Female; Gestational Age; Humans; Infant, Newborn; Intensive Care Units, N

2017
An Atypical Withdrawal Syndrome in Neonates Prenatally Exposed to Gabapentin and Opioids.
    The Journal of pediatrics, 2017, Volume: 181

    Topics: Amines; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid

2017
Early Treatment for Neonatal Abstinence Syndrome: A Palliative Approach.
    American journal of perinatology, 2017, Volume: 34, Issue:6

    Topics: Analgesics, Opioid; Female; Humans; Infant, Newborn; Length of Stay; Male; Methadone; Neonatal Absti

2017
Buprenorphine, Norbuprenorphine, R-Methadone, and S-Methadone Upregulate BCRP/ABCG2 Expression by Activating Aryl Hydrocarbon Receptor in Human Placental Trophoblasts.
    Molecular pharmacology, 2017, Volume: 91, Issue:3

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Buprenorphine; Female; Gene Knockdown Techn

2017
Delayed villous maturation in term placentas exposed to opioid maintenance therapy: a retrospective cohort study.
    American journal of obstetrics and gynecology, 2017, Volume: 216, Issue:4

    Topics: Adult; Buprenorphine; Case-Control Studies; Chorionic Villi; Cohort Studies; Female; Humans; Methado

2017
Response to Smith and Brogly et al. commentaries on Zedler et al.
    Addiction (Abingdon, England), 2016, Volume: 111, Issue:12

    Topics: Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; P

2016
The comparative safety of buprenorphine versus methadone in pregnancy-what about confounding?
    Addiction (Abingdon, England), 2016, Volume: 111, Issue:12

    Topics: Buprenorphine; Female; Humans; Methadone; Neonatal Abstinence Syndrome; Opiate Substitution Treatmen

2016
A case of infant delirium in the neonatal intensive care unit.
    Journal of neonatal-perinatal medicine, 2017, Volume: 10, Issue:1

    Topics: Amines; Analgesics, Opioid; Anti-Anxiety Agents; Cardiac Catheterization; Cyclohexanecarboxylic Acid

2017
Neonatal abstinence syndrome.
    Indian journal of pediatrics, 2008, Volume: 75, Issue:9

    Topics: Female; Humans; Infant; Infant, Newborn; Male; Maternal-Fetal Exchange; Methadone; Morphine; Mothers

2008
Comparison of characteristics of opioid-using pregnant women in rural and urban settings.
    The American journal of drug and alcohol abuse, 2008, Volume: 34, Issue:4

    Topics: Adult; Buprenorphine; Demography; Female; Humans; Mass Screening; Methadone; Narcotic Antagonists; O

2008
Nails of newborns in monitoring drug exposure during pregnancy.
    Forensic science international, 2008, Aug-06, Volume: 179, Issue:2-3

    Topics: Caffeine; Central Nervous System Stimulants; Cocaine; Cotinine; Dopamine Uptake Inhibitors; Female;

2008
Chronic hepatitis C in pregnancy.
    Obstetrics and gynecology, 2008, Volume: 112, Issue:2 Pt 1

    Topics: Adult; Cholestasis; Comorbidity; Female; Hepatitis C, Chronic; Humans; Infant, Newborn; Methadone; N

2008
Drugs and pregnancy--outcomes of women engaged with a specialist perinatal outreach addictions service.
    Drug and alcohol review, 2008, Volume: 27, Issue:5

    Topics: Behavior, Addictive; Cross-Sectional Studies; Female; Health Promotion; Humans; London; Methadone; P

2008
Outcome in infants exposed to methadone in utero.
    BMJ (Clinical research ed.), 2008, Sep-23, Volume: 337

    Topics: Developmental Disabilities; Female; Humans; Infant; Infant, Newborn; Methadone; Narcotics; Pregnancy

2008
Acoustic cry characteristics of infants exposed to methadone during pregnancy.
    Acta paediatrica (Oslo, Norway : 1992), 2009, Volume: 98, Issue:1

    Topics: Abnormalities, Drug-Induced; Acoustics; Analgesics, Opioid; Crying; Female; Humans; Infant Welfare;

2009
Newer obstetric analgesics; preliminary evaluation of compounds No. 10720 and No. 10820 (dolophine).
    American journal of obstetrics and gynecology, 1948, Volume: 55, Issue:6

    Topics: Analgesia; Analgesics; Anesthesia; Anesthesiology; Female; Humans; Methadone; Obstetrics; Pregnancy

1948
Maternal and neonatal effects of substance abuse during pregnancy: our ten-year experience.
    Yonsei medical journal, 2008, Oct-31, Volume: 49, Issue:5

    Topics: Adult; Apgar Score; Birth Weight; Croatia; Female; Heroin; Heroin Dependence; Humans; Incidence; Inf

2008
High-dose methadone in pregnant women and its effect on duration of neonatal abstinence syndrome.
    American journal of obstetrics and gynecology, 2009, Volume: 200, Issue:1

    Topics: Adult; Anticonvulsants; Cohort Studies; Dose-Response Relationship, Drug; Female; Humans; Infant, Ne

2009
Distribution of saquinavir, methadone, and buprenorphine in maternal brain, placenta, and fetus during two different gestational stages of pregnancy in mice.
    Journal of pharmaceutical sciences, 2009, Volume: 98, Issue:8

    Topics: Animals; Brain; Buprenorphine; Female; Fetal Development; Fetus; Maternal Exposure; Maternal-Fetal E

2009
[Substitution treatment of drug addicts during pregnancy: consequences for the children?].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2009, Feb-12, Volume: 129, Issue:4

    Topics: Buprenorphine; Developmental Disabilities; Female; Humans; Infant, Newborn; Methadone; Narcotics; Ne

2009
Maternal methadone use in pregnancy: factors associated with the development of neonatal abstinence syndrome and implications for healthcare resources.
    BJOG : an international journal of obstetrics and gynaecology, 2009, Volume: 116, Issue:5

    Topics: Adolescent; Adult; Breast Feeding; Dose-Response Relationship, Drug; Drug Users; Female; Gestational

2009
Opioid maintenance treatment during pregnancy: occurrence and severity of neonatal abstinence syndrome. A national prospective study.
    European addiction research, 2009, Volume: 15, Issue:3

    Topics: Adult; Buprenorphine; Cohort Studies; Female; Humans; Infant, Newborn; Male; Methadone; Neonatal Abs

2009
Comparison of drugs of abuse detection in meconium by EMIT II and ELISA.
    Journal of analytical toxicology, 2009, Volume: 33, Issue:3

    Topics: Amphetamines; Analgesics, Opioid; Barbiturates; Benzodiazepines; Cannabinoids; Chromatography, Liqui

2009
Buprenorphine and pregnancy.
    Prescrire international, 2009, Volume: 18, Issue:99

    Topics: Buprenorphine; Congenital Abnormalities; Female; France; Humans; Infant, Newborn; Methadone; Neonata

2009
Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy.
    The American journal of drug and alcohol abuse, 2009, Volume: 35, Issue:3

    Topics: Acute Disease; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Buprenorphine; Controlled Clinic

2009
Women treated with methadone are at high risk for poor obstetrical and neonatal outcome.
    American journal of obstetrics and gynecology, 2009, Volume: 201, Issue:3

    Topics: Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Sy

2009
The influence of maternal opiate use in pregnancy on second trimester biochemical markers for Down syndrome.
    Prenatal diagnosis, 2009, Volume: 29, Issue:9

    Topics: Adult; Biomarkers; Case-Control Studies; Down Syndrome; Female; Heroin; Humans; Methadone; Opioid-Re

2009
The impact of cocaine and heroin on the placental transfer of methadone.
    Reproductive biology and endocrinology : RB&E, 2009, Jun-11, Volume: 7

    Topics: Antipyrine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbon Radioisotopes; Cocaine;

2009
Pregnancy and neonatal characteristics of opioid-dependent Indigenous Australians: a rural and metropolitan comparison.
    The Australian & New Zealand journal of obstetrics & gynaecology, 2009, Volume: 49, Issue:3

    Topics: Adult; Analgesics, Opioid; Australia; Female; Humans; Infant, Newborn; Methadone; Native Hawaiian or

2009
Methadone and buprenorphine prescribing and referral practices in US prison systems: results from a nationwide survey.
    Drug and alcohol dependence, 2009, 11-01, Volume: 105, Issue:1-2

    Topics: Buprenorphine; Drug Utilization; Female; Health Care Surveys; Heroin Dependence; Humans; Male; Metha

2009
Risk factors for preterm birth among opiate-addicted gravid women in a methadone treatment program.
    American journal of obstetrics and gynecology, 2009, Volume: 201, Issue:3

    Topics: Adult; Analgesics, Opioid; Comorbidity; Female; Humans; Methadone; Odds Ratio; Opioid-Related Disord

2009
Efficacy of oral sucrose in infants of methadone-maintained mothers.
    Neonatology, 2010, Volume: 97, Issue:1

    Topics: Administration, Oral; Adult; Analgesia; Analgesics; Blood Specimen Collection; Female; Gestational A

2010
Development and validation of a liquid chromatography mass spectrometry assay for the simultaneous quantification of methadone, cocaine, opiates and metabolites in human umbilical cord.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Oct-01, Volume: 877, Issue:27

    Topics: Chromatography, Liquid; Cocaine; Drug Stability; Female; Humans; Least-Squares Analysis; Mass Spectr

2009
Simultaneous quantification of methadone, cocaine, opiates, and metabolites in human placenta by liquid chromatography-mass spectrometry.
    Journal of analytical toxicology, 2009, Volume: 33, Issue:5

    Topics: Adult; Analgesics, Opioid; Chromatography, High Pressure Liquid; Cocaine; Female; Humans; Methadone;

2009
Prenatal methadone exposure and neonatal neurobehavioral functioning.
    Pediatric research, 2009, Volume: 66, Issue:6

    Topics: Analysis of Variance; Female; Humans; Infant, Newborn; Lethargy; Maternal Exposure; Methadone; Movem

2009
S-Methadone augments R-methadone induced respiratory depression in the neonatal guinea pig.
    Respiratory physiology & neurobiology, 2009, Dec-31, Volume: 169, Issue:3

    Topics: Age Factors; Analgesics, Opioid; Analysis of Variance; Animals; Animals, Newborn; Disease Models, An

2009
Treatment of neonatal abstinence syndrome with clonidine and chloral hydrate.
    Acta paediatrica (Oslo, Norway : 1992), 2010, Volume: 99, Issue:2

    Topics: Blood Pressure; Chloral Hydrate; Clonidine; Drug Therapy, Combination; Female; Humans; Hypnotics and

2010
Comparative effects of drugs on P-glycoprotein expression and activity using rat and human trophoblast models.
    Toxicology in vitro : an international journal published in association with BIBRA, 2010, Volume: 24, Issue:2

    Topics: Animals; Aspirin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Dose-Res

2010
Drug addiction during pregnancy: correlations between the placental health and the newborn's outcome - elaboration of a predictive score.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2009, Volume: 25, Issue:12

    Topics: Adult; Analgesics, Opioid; Cannabis; Cocaine; Ethanol; Female; Gestational Age; Humans; Infant, Newb

2009
Screening for hepatitis C virus infection in methadone-maintained mothers and their infants.
    The Medical journal of Australia, 2009, Nov-16, Volume: 191, Issue:10

    Topics: Adult; Analgesics, Opioid; Female; Hepatitis C; Humans; Infant; Infant, Newborn; Methadone; Neonatal

2009
Patterns in sleep-wakefulness in three-month old infants exposed to methadone or buprenorphine.
    Early human development, 2009, Volume: 85, Issue:12

    Topics: Adult; Buprenorphine; Chronobiology Disorders; Female; Humans; Infant; Infant Behavior; Infant, Newb

2009
Characteristics of opioid-using pregnant women who accept or refuse participation in a clinical trial: screening results from the MOTHER study.
    The American journal of drug and alcohol abuse, 2009, Volume: 35, Issue:6

    Topics: Adolescent; Adult; Demography; Female; Humans; Methadone; Opioid-Related Disorders; Patient Selectio

2009
Gas chromatography-mass spectrometry assay for the simultaneous quantification of drugs of abuse in human placenta at 12th week of gestation.
    Forensic science international, 2010, Mar-20, Volume: 196, Issue:1-3

    Topics: Abortion, Induced; Amphetamines; Cocaine; Cotinine; Dronabinol; Female; Forensic Toxicology; Ganglio

2010
The impact of mood disorders on the delivery and neonatal outcomes of methadone-maintained pregnant patients.
    The American journal of drug and alcohol abuse, 2009, Volume: 35, Issue:5

    Topics: Adult; Analysis of Variance; Chi-Square Distribution; Diagnosis, Dual (Psychiatry); Female; Genital

2009
The impact of mood disorders on the delivery and neonatal outcomes of methadone-maintained pregnant patients.
    The American journal of drug and alcohol abuse, 2009, Volume: 35, Issue:5

    Topics: Adult; Analysis of Variance; Chi-Square Distribution; Diagnosis, Dual (Psychiatry); Female; Genital

2009
The impact of mood disorders on the delivery and neonatal outcomes of methadone-maintained pregnant patients.
    The American journal of drug and alcohol abuse, 2009, Volume: 35, Issue:5

    Topics: Adult; Analysis of Variance; Chi-Square Distribution; Diagnosis, Dual (Psychiatry); Female; Genital

2009
The impact of mood disorders on the delivery and neonatal outcomes of methadone-maintained pregnant patients.
    The American journal of drug and alcohol abuse, 2009, Volume: 35, Issue:5

    Topics: Adult; Analysis of Variance; Chi-Square Distribution; Diagnosis, Dual (Psychiatry); Female; Genital

2009
Infant autonomic functioning and neonatal abstinence syndrome.
    Drug and alcohol dependence, 2010, Jun-01, Volume: 109, Issue:1-3

    Topics: Adult; Apgar Score; Autonomic Nervous System; Cocaine-Related Disorders; Data Interpretation, Statis

2010
Miadone (physeptone) in obstetrics.
    Lancet (London, England), 1947, Sep-06, Volume: 2, Issue:6471

    Topics: Female; Humans; Methadone; Obstetrics; Pregnancy

1947
Amidone (miadone) as an obstetric analgesic: trial in 62 cases.
    Lancet (London, England), 1947, Oct-04, Volume: 2, Issue:6475

    Topics: Analgesics; Female; Humans; Methadone; Pregnancy

1947
Newer obstetric analgesics; compounds No. 10720 and No. 10820, dolophine.
    Bulletin of the University of Minnesota Hospitals and Minnesota Medical Foundation. University of Minnesota. Hospitals, 1947, Apr-18, Volume: 18, Issue:23

    Topics: Analgesics; Anesthesia; Anesthesia, Obstetrical; Anesthesiology; Female; Gynecology; Methadone; Obst

1947
Growth restriction in pregnancies of opioid-dependent mothers.
    Archives of disease in childhood. Fetal and neonatal edition, 2010, Volume: 95, Issue:4

    Topics: Adult; Body Mass Index; Dose-Response Relationship, Drug; Epidemiologic Methods; Female; Fetal Growt

2010
Ophthalmic, clinical and visual electrophysiological findings in children born to mothers prescribed substitute methadone in pregnancy.
    The British journal of ophthalmology, 2010, Volume: 94, Issue:6

    Topics: Child; Child, Preschool; Evoked Potentials, Visual; Eye Diseases; Female; Humans; Infant; Maternal-F

2010
Multidisciplinary antenatal care for opiate-using women: Child-care issues.
    Drug and alcohol review, 2010, Volume: 29, Issue:2

    Topics: Appointments and Schedules; Female; Foster Home Care; Heroin; Heroin Dependence; Humans; Infant, New

2010
Relationship between maternal methadone dose at delivery and neonatal abstinence syndrome.
    The Journal of pediatrics, 2010, Volume: 157, Issue:3

    Topics: Cohort Studies; Female; Humans; Incidence; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinenc

2010
Infant neurobehavior following prenatal exposure to methadone or buprenorphine: results from the neonatal intensive care unit network neurobehavioral scale.
    Substance use & misuse, 2010, Volume: 45, Issue:13

    Topics: Adult; Akathisia, Drug-Induced; Buprenorphine; Female; Humans; Infant, Newborn; Intensive Care Units

2010
Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome.
    Journal of perinatology : official journal of the California Perinatal Association, 2011, Volume: 31, Issue:1

    Topics: Breast Feeding; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Infant, Premature

2011
Enhancement of tolerance development to morphine in rats prenatally exposed to morphine, methadone, and buprenorphine.
    Journal of biomedical science, 2010, Jun-07, Volume: 17

    Topics: Analgesics; Animals; Buprenorphine; Disease Models, Animal; Drug Tolerance; Female; Heroin Dependenc

2010
Gender and NAS: does sex matter?
    Drug and alcohol dependence, 2010, Nov-01, Volume: 112, Issue:1-2

    Topics: Analgesics, Opioid; Female; Humans; Infant, Newborn; Male; Methadone; Morphine; Neonatal Abstinence

2010
Excretion of methadone in sweat of pregnant women throughout gestation after controlled methadone administration.
    Therapeutic drug monitoring, 2010, Volume: 32, Issue:4

    Topics: Adult; Analgesics, Opioid; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Drug Monitoring;

2010
Perinatal risk factors for the neonatal abstinence syndrome in infants born to women on methadone maintenance therapy.
    The Australian & New Zealand journal of obstetrics & gynaecology, 2010, Volume: 50, Issue:3

    Topics: Adult; Female; Humans; Infant, Newborn; Logistic Models; Methadone; Narcotics; Neonatal Abstinence S

2010
High-throughput simultaneous analysis of buprenorphine, methadone, cocaine, opiates, nicotine, and metabolites in oral fluid by liquid chromatography tandem mass spectrometry.
    Analytical and bioanalytical chemistry, 2010, Volume: 398, Issue:2

    Topics: Anesthetics, Local; Buprenorphine; Chromatography, Liquid; Cocaine; Female; Ganglionic Stimulants; H

2010
Postnatal weight loss in substitute methadone-exposed infants: implications for the management of breast feeding.
    Archives of disease in childhood. Fetal and neonatal edition, 2012, Volume: 97, Issue:3

    Topics: Adolescent; Adult; Birth Weight; Bottle Feeding; Breast Feeding; Female; Gestational Age; Humans; In

2012
Methadone disposition in oral fluid during pharmacotherapy for opioid-dependence.
    Forensic science international, 2011, Mar-20, Volume: 206, Issue:1-3

    Topics: Chromatography, Liquid; Female; Humans; Hydrogen-Ion Concentration; Mass Spectrometry; Methadone; Me

2011
A special type of 'hard-to-reach' patient: experiences of pregnant women on methadone.
    Journal of primary health care, 2010, Volume: 2, Issue:1

    Topics: Female; Humans; Interviews as Topic; Maternal Health Services; Methadone; New Zealand; Opioid-Relate

2010
Prenatal methadone exposure, meconium biomarker concentrations and neonatal abstinence syndrome.
    Addiction (Abingdon, England), 2010, Volume: 105, Issue:12

    Topics: Adult; Analgesics, Opioid; Cocaine; Cocaine-Related Disorders; Female; Gestational Age; Humans; Infa

2010
Neonatal and maternal outcomes following maternal use of buprenorphine or methadone during pregnancy: findings of a retrospective audit.
    Women and birth : journal of the Australian College of Midwives, 2011, Volume: 24, Issue:1

    Topics: Adult; Buprenorphine; Female; Humans; Infant, Newborn; Maternal Health Services; Maternal Welfare; M

2011
Infant mortality among women on a methadone program during pregnancy.
    Drug and alcohol review, 2010, Volume: 29, Issue:5

    Topics: Adult; Female; Humans; Infant Mortality; Infant, Newborn; Live Birth; Medical Record Linkage; Methad

2010
Maternal methadone therapy increases QTc interval in newborn infants.
    Archives of disease in childhood. Fetal and neonatal edition, 2011, Volume: 96, Issue:2

    Topics: Case-Control Studies; Electrocardiography; Female; Humans; Infant, Newborn; Long QT Syndrome; Male;

2011
Association between intrapartum fetal heart rate patterns and neonatal abstinence syndrome in methadone exposed neonates.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2011, Volume: 24, Issue:7

    Topics: Adult; Analgesics, Opioid; Female; Heart Rate, Fetal; Humans; Infant, Newborn; Labor, Obstetric; Mat

2011
Methadone and perinatal outcomes: a retrospective cohort study.
    American journal of obstetrics and gynecology, 2011, Volume: 204, Issue:2

    Topics: Age Factors; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Methadone; Narcotics

2011
Higher maternal doses of methadone does not increase neonatal abstinence syndrome.
    Journal of substance abuse treatment, 2011, Volume: 40, Issue:3

    Topics: Adult; Birth Weight; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Methadone; N

2011
[Assisted reproductive technique for an opiates dependant couple].
    Gynecologie, obstetrique & fertilite, 2011, Volume: 39, Issue:2

    Topics: Adult; Female; Fertilization in Vitro; Hepatitis C, Chronic; Humans; Male; Methadone; Opiate Substit

2011
Estimated infant exposure to enantiomer-specific methadone levels in breastmilk.
    Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, 2011, Volume: 6, Issue:6

    Topics: Adolescent; Adult; Analgesics, Opioid; Breast Feeding; Dose-Response Relationship, Drug; Female; Hum

2011
Changes in methadone maintenance therapy during and after pregnancy.
    Journal of substance abuse treatment, 2011, Volume: 41, Issue:4

    Topics: Adult; Analgesics, Opioid; Computers; Dose-Response Relationship, Drug; Drug Administration Schedule

2011
Methadone and perinatal outcomes: another perspective.
    American journal of obstetrics and gynecology, 2011, Volume: 205, Issue:5

    Topics: Female; Humans; Methadone; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Opioid-Relat

2011
Duration of methadone maintenance treatment during pregnancy and pregnancy outcome parameters in women with opiate addiction.
    Journal of addiction medicine, 2012, Volume: 6, Issue:1

    Topics: Adult; Birth Weight; Dose-Response Relationship, Drug; Female; Gestational Age; Humans; Infant, Newb

2012
Neonatal abstinence syndrome: transitioning methadone-treated infants from an inpatient to an outpatient setting.
    Journal of perinatology : official journal of the California Perinatal Association, 2012, Volume: 32, Issue:6

    Topics: Ambulatory Care; Female; Hospitalization; Humans; Infant, Newborn; Infant, Premature, Diseases; Leng

2012
The relationship between maternal opioid agonists and psychiatric medications on length of hospitalization for neonatal abstinence syndrome.
    Journal of addiction medicine, 2011, Volume: 5, Issue:4

    Topics: Boston; Buprenorphine; Cross-Sectional Studies; Drug Interactions; Drug Therapy, Combination; Female

2011
The worldwide opioid epidemic: implications for treatment and research in pregnancy and the newborn.
    Paediatric drugs, 2011, Oct-01, Volume: 13, Issue:5

    Topics: Analgesics, Opioid; Biomedical Research; Buprenorphine; Female; Humans; Infant, Newborn; Internation

2011
Efficacy versus effectiveness of buprenorphine and methadone maintenance in pregnancy.
    Journal of addictive diseases, 2011, Volume: 30, Issue:4

    Topics: Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; P

2011
Pregnancies exposed to methadone, methadone and other illicit substances, and poly-drugs without methadone: a comparison of fetal neurobehaviors and infant outcomes.
    Drug and alcohol dependence, 2012, May-01, Volume: 122, Issue:3

    Topics: Adult; Female; Fetal Monitoring; Humans; Illicit Drugs; Infant, Newborn; Methadone; Neonatal Abstine

2012
Pregnancies exposed to methadone, methadone and other illicit substances, and poly-drugs without methadone: a comparison of fetal neurobehaviors and infant outcomes.
    Drug and alcohol dependence, 2012, May-01, Volume: 122, Issue:3

    Topics: Adult; Female; Fetal Monitoring; Humans; Illicit Drugs; Infant, Newborn; Methadone; Neonatal Abstine

2012
Pregnancies exposed to methadone, methadone and other illicit substances, and poly-drugs without methadone: a comparison of fetal neurobehaviors and infant outcomes.
    Drug and alcohol dependence, 2012, May-01, Volume: 122, Issue:3

    Topics: Adult; Female; Fetal Monitoring; Humans; Illicit Drugs; Infant, Newborn; Methadone; Neonatal Abstine

2012
Pregnancies exposed to methadone, methadone and other illicit substances, and poly-drugs without methadone: a comparison of fetal neurobehaviors and infant outcomes.
    Drug and alcohol dependence, 2012, May-01, Volume: 122, Issue:3

    Topics: Adult; Female; Fetal Monitoring; Humans; Illicit Drugs; Infant, Newborn; Methadone; Neonatal Abstine

2012
The impact of infant feeding method on neonatal abstinence scores of methadone-exposed infants.
    Advances in neonatal care : official journal of the National Association of Neonatal Nurses, 2011, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Analysis of Variance; Breast Feeding; Female; Humans; Infant Formula; Infant, New

2011
A pilot study of the nutritional status of opiate-using pregnant women on methadone maintenance therapy.
    Substance use & misuse, 2012, Volume: 47, Issue:3

    Topics: Adult; Body Composition; Body Mass Index; Energy Intake; Fatty Acids, Essential; Female; Humans; Mal

2012
Medication-assisted treatment in criminal justice agencies affiliated with the criminal justice-drug abuse treatment studies (CJ-DATS): availability, barriers, and intentions.
    Substance abuse, 2012, Volume: 33, Issue:1

    Topics: Adult; Buprenorphine; Crime; Criminal Law; Data Collection; Female; Humans; Male; Methadone; Naltrex

2012
Strength in numbers: a step closer to standardising perinatal care for drug-misusing women and their infants.
    Journal of perinatology : official journal of the California Perinatal Association, 2012, Volume: 32, Issue:2

    Topics: Female; Humans; Methadone; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Pregna

2012
Unplanned pregnancy and contraceptive use in women attending drug treatment services.
    The Australian & New Zealand journal of obstetrics & gynaecology, 2012, Volume: 52, Issue:2

    Topics: Adult; Buprenorphine; Contraception Behavior; Delivery of Health Care, Integrated; Drug Users; Femal

2012
Methadone and perinatal outcomes: a prospective cohort study.
    Addiction (Abingdon, England), 2012, Volume: 107, Issue:8

    Topics: Adult; Benzodiazepines; Dose-Response Relationship, Drug; Female; Heroin Dependence; Humans; Infant,

2012
Opioid dependency in pregnancy and length of stay for neonatal abstinence syndrome.
    Journal of obstetric, gynecologic, and neonatal nursing : JOGNN, 2012, Volume: 41, Issue:2

    Topics: Adult; Buprenorphine; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule

2012
Methadone and metabolites in hair of methadone-assisted pregnant women and their infants.
    Therapeutic drug monitoring, 2012, Volume: 34, Issue:3

    Topics: Adolescent; Adult; Female; Hair; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; O

2012
Perinatal effects of combined use of heroin, methadone, and amphetamine during pregnancy and quantitative measurement of metabolites in hair.
    Pediatrics and neonatology, 2012, Volume: 53, Issue:2

    Topics: Adult; Amphetamine; Electroencephalography; Female; Fetus; Gas Chromatography-Mass Spectrometry; Hai

2012
Development of a substance abuse program for opioid-dependent nonurban pregnant women improves outcome.
    Journal of addiction medicine, 2012, Volume: 6, Issue:2

    Topics: Buprenorphine; Cohort Studies; Combined Modality Therapy; Female; Health Services Accessibility; Hum

2012
ACOG Committee Opinion No. 524: Opioid abuse, dependence, and addiction in pregnancy.
    Obstetrics and gynecology, 2012, Volume: 119, Issue:5

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence S

2012
Are infants exposed to methadone in utero at an increased risk for mortality?
    Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique, 2012, Volume: 19, Issue:2

    Topics: Adult; Analgesics, Opioid; Cause of Death; Female; Humans; Infant; Infant Mortality; Infant, Newborn

2012
Maternal and neonatal outcomes following methadone substitution during pregnancy.
    Archives of gynecology and obstetrics, 2012, Volume: 286, Issue:4

    Topics: Adult; Analgesics, Opioid; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Premature; Me

2012
Subsequent anxiety-related behavior in rats exposed to low-dose methadone during gestation, lactation or both periods consecutively.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 102, Issue:2

    Topics: Animals; Anxiety; Behavior, Animal; Dose-Response Relationship, Drug; Female; Growth; Lactation; Met

2012
Treatment of opioid dependence in the setting of pregnancy.
    The Psychiatric clinics of North America, 2012, Volume: 35, Issue:2

    Topics: Adolescent; Alcohol-Related Disorders; Analgesics, Opioid; Buprenorphine; Child; Comorbidity; Delive

2012
Neural tract development of infants born to methadone-maintained mothers.
    Pediatric neurology, 2012, Volume: 47, Issue:1

    Topics: Analgesics, Opioid; Brain; Brain Mapping; Developmental Disabilities; Diffusion Tensor Imaging; Fema

2012
Neurodevelopmental investigation of the mirror neurone system in children of women receiving opioid maintenance therapy during pregnancy.
    Addiction (Abingdon, England), 2013, Volume: 108, Issue:1

    Topics: Adult; Analysis of Variance; Buprenorphine; Case-Control Studies; Child, Preschool; Developmental Di

2013
Quantitative prediction of CYP2B6 induction by estradiol during pregnancy: potential explanation for increased methadone clearance during pregnancy.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:2

    Topics: Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Biotransformation; Bupropion; Carbamazepine; Cell

2013
Neonatal outcomes following in utero exposure to methadone or buprenorphine: a National Cohort Study of opioid-agonist treatment of Pregnant Women in Norway from 1996 to 2009.
    Drug and alcohol dependence, 2013, Jan-01, Volume: 127, Issue:1-3

    Topics: Adult; Analgesics, Opioid; Buprenorphine; Cohort Studies; Female; Follow-Up Studies; Humans; Infant,

2013
Pharmacologic evidence to support clinical decision making for peripartum methadone treatment.
    Psychopharmacology, 2013, Volume: 225, Issue:2

    Topics: Adolescent; Adult; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19;

2013
Methadone use in pregnancy: evidence of progression in the severity of addiction.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2012, Volume: 32, Issue:8

    Topics: Adult; England; Female; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy; Pregnancy

2012
Patterns of symptom reporting during pregnancy comparing opioid maintained and control women.
    Journal of addiction medicine, 2012, Volume: 6, Issue:4

    Topics: Adult; Buprenorphine; Case-Control Studies; Female; Humans; Methadone; Opiate Substitution Treatment

2012
Methadone dosing and prescribed medication use in a prospective cohort of opioid-dependent pregnant women.
    Addiction (Abingdon, England), 2013, Volume: 108, Issue:4

    Topics: Anti-Bacterial Agents; Antidepressive Agents; Benzodiazepines; Female; Humans; Hypnotics and Sedativ

2013
Efficacy and safety of intraoperative intravenous methadone during general anaesthesia for caesarean delivery: a retrospective case-control study.
    International journal of obstetric anesthesia, 2013, Volume: 22, Issue:1

    Topics: Adult; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Genera

2013
Comments on: Efficacy versus effectiveness of buprenorphine and methadone maintenance in pregnancy.
    Journal of addictive diseases, 2012, Volume: 31, Issue:4

    Topics: Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; P

2012
Dual dilemma-should naltrexone be used in the treatment of opioid-dependent pregnant women?
    Addiction (Abingdon, England), 2013, Volume: 108, Issue:2

    Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naltrexone; Narcotic Antagonists; Narcoti

2013
Blocking endogenous opioids during development--do we understand the consequences?
    Addiction (Abingdon, England), 2013, Volume: 108, Issue:2

    Topics: Animals; Brain; Buprenorphine; Female; Fetal Development; Humans; Methadone; Naltrexone; Narcotic An

2013
Management of the pregnant substance abusing woman.
    Clinical obstetrics and gynecology, 2013, Volume: 56, Issue:1

    Topics: Analgesics, Opioid; Female; Humans; Maternal Health Services; Methadone; Opioid-Related Disorders; P

2013
Simultaneous determination of opiates, methadone, amphetamines, cocaine, and metabolites in human placenta and umbilical cord by LC-MS/MS.
    Analytical and bioanalytical chemistry, 2013, Volume: 405, Issue:12

    Topics: Amphetamine; Analgesics, Opioid; Chromatography, Liquid; Cocaine; Female; Humans; Limit of Detection

2013
Methadone trough levels in pregnancy.
    American journal of obstetrics and gynecology, 2002, Volume: 187, Issue:5

    Topics: Female; Heroin; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy; Pregnancy Complic

2002
Relationship between maternal methadone dosage and neonatal withdrawal.
    Obstetrics and gynecology, 2002, Volume: 100, Issue:6

    Topics: Adult; Analysis of Variance; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration S

2002
Strabismus in infants of opiate-dependent mothers.
    Acta paediatrica (Oslo, Norway : 1992), 2003, Volume: 92, Issue:3

    Topics: Australia; Codeine; Cross-Sectional Studies; Female; Heroin; Humans; Infant; Infant, Newborn; Male;

2003
Prenatal methadone exposure: effects on behavior in early infancy.
    Pediatric pharmacology (New York, N.Y.), 1982, Volume: 2, Issue:2

    Topics: Adult; Analysis of Variance; Child Development; Female; Follow-Up Studies; Humans; Infant; Infant Be

1982
Maternal drug use and length of neonatal unit stay.
    Addiction (Abingdon, England), 2003, Volume: 98, Issue:6

    Topics: Adult; Female; Humans; Infant, Newborn; Intensive Care, Neonatal; Length of Stay; London; Methadone;

2003
Is opiate detoxification unsafe in pregnancy?
    Journal of substance abuse treatment, 2003, Volume: 24, Issue:4

    Topics: Abortion, Spontaneous; Adult; Female; Heroin; Humans; Methadone; Obstetric Labor, Premature; Opioid-

2003
Neonatal hair analysis contribution to establishing a gestational drug exposure profile and predicting a withdrawal syndrome.
    Therapeutic drug monitoring, 2003, Volume: 25, Issue:4

    Topics: Cannabinoids; Cocaine; Female; Gas Chromatography-Mass Spectrometry; Hair; Humans; Infant, Newborn;

2003
[Coagulation effect of methadon during labor; comparative biological, biochemical and biophysical studies].
    Therapie der Gegenwart, 1956, Volume: 95, Issue:3

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Female; Humans; Labor, Obstetric; Methadone; Pain M

1956
Dipipanone hydrochloride as an adjunct to anaesthesia in obstetrics and surgery.
    British medical journal, 1957, May-11, Volume: 1, Issue:5027

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Female; Humans; Labor, Obstetric; Methadone; Obstet

1957
Dipipanone hydrochloride (pipadone) as a pre-delivery sedative and analgesic.
    Canadian Medical Association journal, 1958, Sep-15, Volume: 79, Issue:6

    Topics: Analgesia; Analgesics; Anesthesia; Anesthesia and Analgesia; Female; Humans; Hypnotics and Sedatives

1958
Management of the narcotic withdrawal syndrome in the neonate.
    Pediatric clinics of North America, 1963, Volume: 10

    Topics: Barbiturates; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exc

1963
CONGENITAL NEONATAL NARCOTICS ADDICTION: A NATURAL HISTORY.
    American journal of public health and the nation's health, 1964, Volume: 54

    Topics: Chlorpromazine; Female; Humans; Maternal-Fetal Exchange; Meperidine; Methadone; Morphine Dependence;

1964
[Painless labor with polamidone S..].
    Medicinski glasnik, 1954, Volume: 8, Issue:9

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Female; Humans; Labor, Obstetric; Methadone; Pain M

1954
Maternal methadone dose and neonatal withdrawal.
    American journal of obstetrics and gynecology, 2003, Volume: 189, Issue:2

    Topics: Benzodiazepines; Dose-Response Relationship, Drug; Female; Heroin Dependence; Humans; Infant, Newbor

2003
Impact of methadone program philosophy changes on early treatment outcomes.
    Journal of addictive diseases, 2003, Volume: 22, Issue:3

    Topics: Adult; Clinical Protocols; Cohort Studies; Cross-Sectional Studies; Dose-Response Relationship, Drug

2003
Specialized drug liaison midwife services for pregnant opioid dependent women in Dublin, Ireland.
    Journal of substance abuse treatment, 2004, Volume: 26, Issue:1

    Topics: Adult; Crime; Female; Humans; Infant, Newborn; Ireland; Mental Disorders; Methadone; Midwifery; Narc

2004
Outcomes of infants born to mothers receiving methadone for pain management in pregnancy.
    Archives of disease in childhood. Fetal and neonatal edition, 2004, Volume: 89, Issue:1

    Topics: Analgesics, Opioid; Chronic Disease; Delivery, Obstetric; Drug Administration Schedule; Female; Gest

2004
Use of methadone-scopolamine in obstetric analgesia.
    Journal of the American Medical Association, 1952, Apr-05, Volume: 148, Issue:14

    Topics: Analgesia, Obstetrical; Female; Humans; Labor, Obstetric; Methadone; Pregnancy; Scopolamine; Work

1952
[Polamidon C in obstetrics].
    Geburtshilfe und Frauenheilkunde, 1952, Volume: 12, Issue:4

    Topics: Female; Humans; Labor, Obstetric; Methadone; Obstetrics; Pregnancy; Work

1952
["Is opiate detoxification unsafe in pregnancy?"].
    Journal of substance abuse treatment, 2004, Volume: 26, Issue:2

    Topics: Adult; Female; Humans; Infant, Newborn; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy; P

2004
Methadone maintenance vs. implantable naltrexone treatment in the pregnant heroin user.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2004, Volume: 85, Issue:2

    Topics: Australia; Drug Implants; Female; Heroin Dependence; Humans; Methadone; Naltrexone; Narcotic Antagon

2004
Does pregnancy affect outcome of methadone maintenance treatment?
    Journal of substance abuse treatment, 2004, Volume: 26, Issue:4

    Topics: Adult; Case-Control Studies; Comorbidity; Female; Heroin Dependence; Humans; Mental Disorders; Metha

2004
French field experience with buprenorphine.
    The American journal on addictions, 2004, Volume: 13 Suppl 1

    Topics: Adult; Buprenorphine; Cause of Death; Cross-Cultural Comparison; Drug Approval; Drug Overdose; Drug

2004
Methadone metabolism by human placenta.
    Biochemical pharmacology, 2004, Aug-01, Volume: 68, Issue:3

    Topics: Analgesics, Opioid; Aromatase; DNA, Complementary; Estradiol; Female; Humans; Kinetics; Methadone; M

2004
Differential effects of gestational buprenorphine, naloxone, and methadone on mesolimbic mu opioid and ORL1 receptor G protein coupling.
    Brain research. Developmental brain research, 2004, Jul-19, Volume: 151, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Animals, Newborn; Autoradiography; Buprenorphine; Dose-Response Relatio

2004
Impact of spinal anaesthesia and obesity on maternal respiratory function during elective Caesarean section.
    Anaesthesia, 2004, Volume: 59, Issue:8

    Topics: Adult; Analgesics, Opioid; Anesthesia, Obstetrical; Anesthesia, Spinal; Body Mass Index; Cesarean Se

2004
Neonatal abstinence syndrome in methadone-exposed infants is altered by level of prenatal tobacco exposure.
    Drug and alcohol dependence, 2004, Sep-06, Volume: 75, Issue:3

    Topics: Adult; Analysis of Variance; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrom

2004
Improving the management of opioid-dependent pregnancies.
    American journal of obstetrics and gynecology, 2004, Volume: 190, Issue:6

    Topics: Cohort Studies; Dose-Response Relationship, Drug; Female; Gestational Age; Humans; Infant, Newborn;

2004
Can methadone concentrations predict the severity of withdrawal in infants at risk of neonatal abstinence syndrome?
    Archives of disease in childhood. Fetal and neonatal edition, 2004, Volume: 89, Issue:5

    Topics: Adult; Drug Administration Schedule; Female; Fetal Blood; Humans; Infant, Newborn; Male; Maternal-Fe

2004
Bidirectional transfer of methadone across human placenta.
    Biochemical pharmacology, 2005, Jan-01, Volume: 69, Issue:1

    Topics: Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Maternal-Fetal Exchange; Meth

2005
Challenges that opioid-dependent women present to the obstetric anaesthetist.
    Anaesthesia and intensive care, 2004, Volume: 32, Issue:4

    Topics: Adult; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Anesthesia, Obstetrical; Cesarean Sect

2004
Methadone maintenance program in a Swiss perinatal center: (I): Management and outcome of 89 pregnancies.
    Acta obstetricia et gynecologica Scandinavica, 2005, Volume: 84, Issue:2

    Topics: Adult; Birth Weight; Cocaine-Related Disorders; Cohort Studies; Dose-Response Relationship, Drug; Dr

2005
Methadone maintenance program in pregnancy in a Swiss perinatal center (II): neonatal outcome and social resources.
    Acta obstetricia et gynecologica Scandinavica, 2005, Volume: 84, Issue:2

    Topics: Adult; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fetal

2005
Secondary amenorrhea: an unusual twist.
    Journal of pediatric and adolescent gynecology, 2005, Volume: 18, Issue:1

    Topics: Adolescent; Amenorrhea; Clitoris; Female; Humans; Methadone; Narcotics; Pregnancy; Prenatal Exposure

2005
Role of P-glycoprotein in transplacental transfer of methadone.
    Biochemical pharmacology, 2005, Jun-15, Volume: 69, Issue:12

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Dose-Response Relationship, Drug

2005
Attitudes and practices regarding the use of methadone in US state and federal prisons.
    Journal of urban health : bulletin of the New York Academy of Medicine, 2005, Volume: 82, Issue:3

    Topics: Drug Utilization; Federal Government; Female; Humans; Male; Methadone; Narcotics; Opioid-Related Dis

2005
High-dose methadone maintenance in pregnancy: maternal and neonatal outcomes.
    American journal of obstetrics and gynecology, 2005, Volume: 193, Issue:3 Pt 1

    Topics: Adult; Analgesics, Opioid; Female; Gestational Age; Humans; Infant, Newborn; Length of Stay; Methado

2005
Fetal response to maternal methadone administration.
    American journal of obstetrics and gynecology, 2005, Volume: 193, Issue:3 Pt 1

    Topics: Adult; Analgesics, Opioid; Female; Fetal Movement; Fetus; Heart Rate, Fetal; Humans; Male; Methadone

2005
Fetal response to maternal methadone administration.
    American journal of obstetrics and gynecology, 2005, Volume: 193, Issue:3 Pt 1

    Topics: Adult; Analgesics, Opioid; Female; Fetal Movement; Fetus; Heart Rate, Fetal; Humans; Male; Methadone

2005
Fetal response to maternal methadone administration.
    American journal of obstetrics and gynecology, 2005, Volume: 193, Issue:3 Pt 1

    Topics: Adult; Analgesics, Opioid; Female; Fetal Movement; Fetus; Heart Rate, Fetal; Humans; Male; Methadone

2005
Fetal response to maternal methadone administration.
    American journal of obstetrics and gynecology, 2005, Volume: 193, Issue:3 Pt 1

    Topics: Adult; Analgesics, Opioid; Female; Fetal Movement; Fetus; Heart Rate, Fetal; Humans; Male; Methadone

2005
Pregnancy outcome in women who use opiates.
    European journal of obstetrics, gynecology, and reproductive biology, 2006, Jun-01, Volume: 126, Issue:2

    Topics: Adult; England; Female; Heroin; Humans; Infant, Newborn; Male; Medical Records; Methadone; Neonatal

2006
Prospective multicenter observational study of 260 infants born to 259 opiate-dependent mothers on methadone or high-dose buprenophine substitution.
    Drug and alcohol dependence, 2006, May-20, Volume: 82, Issue:3

    Topics: Adult; Buprenorphine; Female; HIV Seropositivity; Humans; Infant Care; Infant, Newborn; Methadone; N

2006
Changes to methadone clearance during pregnancy.
    European journal of clinical pharmacology, 2005, Volume: 61, Issue:10

    Topics: Adolescent; Adult; Area Under Curve; Chromatography, High Pressure Liquid; Female; Heroin; Heroin De

2005
Mothers in substance abuse treatment: differences in characteristics based on involvement with child welfare services.
    Child abuse & neglect, 2006, Volume: 30, Issue:1

    Topics: Adolescent; Adult; Alcoholism; Ambulatory Care; Amphetamine-Related Disorders; California; Child; Ch

2006
Effect of chronic maternal methadone therapy on intrapartum fetal heart rate patterns.
    Journal of the Society for Gynecologic Investigation, 2006, Volume: 13, Issue:2

    Topics: Adult; Cohort Studies; Ethnicity; Female; Gestational Age; Heart Rate, Fetal; Humans; Methadone; Opi

2006
Buprenorphine replacement therapy: a confirmed benefit.
    Prescrire international, 2006, Volume: 15, Issue:82

    Topics: Benzodiazepines; Buprenorphine; Cohort Studies; Drug Therapy, Combination; Female; France; Heroin De

2006
[A multidisciplinary approach is necessary in the neonatal withdrawal syndrome].
    Nederlands tijdschrift voor geneeskunde, 2006, Apr-08, Volume: 150, Issue:14

    Topics: Adult; Female; Humans; Hypnotics and Sedatives; Infant, Newborn; Male; Methadone; Narcotics; Neonata

2006
Gender differences and pregnant women in a methadone maintenance treatment (MMT) clinic.
    Journal of addictive diseases, 2006, Volume: 25, Issue:2

    Topics: Adult; Age Factors; Cocaine-Related Disorders; Cohort Studies; Comorbidity; Emigration and Immigrati

2006
Methadone metabolism by early gestational age placentas.
    American journal of perinatology, 2006, Volume: 23, Issue:5

    Topics: Aromatase; Female; Gestational Age; Humans; In Vitro Techniques; Methadone; Microsomes; Narcotics; P

2006
The effect of maternal methadone use on the fetal heart pattern: a computerised CTG analysis.
    BJOG : an international journal of obstetrics and gynaecology, 2006, Volume: 113, Issue:8

    Topics: Adult; Cardiotocography; Diagnosis, Computer-Assisted; Female; Heart Rate, Fetal; Humans; Methadone;

2006
A chart review comparing paregoric to methadone in the treatment of neonatal opioid withdrawal.
    Journal of addictive diseases, 2006, Volume: 25, Issue:3

    Topics: Analgesics, Opioid; Documentation; Drug Administration Schedule; Female; Humans; Infant, Newborn; Ma

2006
Substance abuse in pregnancy: opioid substitution in a northern Ireland maternity unit.
    The Ulster medical journal, 2006, Volume: 75, Issue:3

    Topics: Adult; Buprenorphine; Codeine; Female; Heroin Dependence; Humans; Infant, Newborn; Maternal-Fetal Ex

2006
Depression in methadone maintenance treatment patients: rate and risk factors.
    Journal of affective disorders, 2007, Volume: 99, Issue:1-3

    Topics: Adult; Benzodiazepines; Brief Psychiatric Rating Scale; Cocaine; Cocaine-Related Disorders; Comorbid

2007
Mood disorders affect drug treatment success of drug-dependent pregnant women.
    Journal of substance abuse treatment, 2007, Volume: 32, Issue:1

    Topics: Adult; Diagnosis, Dual (Psychiatry); Diagnostic and Statistical Manual of Mental Disorders; Female;

2007
Methadone in pregnancy: treatment retention and neonatal outcomes.
    Addiction (Abingdon, England), 2007, Volume: 102, Issue:2

    Topics: Adult; Female; Humans; Infant, Newborn; Infant, Premature; Infant, Small for Gestational Age; Methad

2007
Methadone-exposed newborn infants: outcome after alterations to a service for mothers and infants.
    Child: care, health and development, 2007, Volume: 33, Issue:2

    Topics: Delivery of Health Care; Female; Humans; Infant Care; Infant, Newborn; Interprofessional Relations;

2007
[Drugs, pregnancy and newborn infants from the viewpoint of pediatric nursing].
    Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege, 2002, Volume: 21, Issue:4

    Topics: Breast Feeding; Education; Female; Humans; Infant, Newborn; Male; Methadone; Mother-Child Relations;

2002
Maternal methadone may cause arrhythmias in neonates.
    Acta paediatrica (Oslo, Norway : 1992), 2007, Volume: 96, Issue:5

    Topics: Electrocardiography; Female; Humans; Infant, Newborn; Long QT Syndrome; Methadone; Narcotics; Pregna

2007
Concentrations of methadone in breast milk and plasma in the immediate perinatal period.
    Journal of human lactation : official journal of International Lactation Consultant Association, 2007, Volume: 23, Issue:2

    Topics: Adult; Analgesics, Opioid; Female; Humans; Infant, Newborn; Male; Methadone; Milk, Human; Postpartum

2007
Sequela of preterm versus term infants born to mothers on a methadone maintenance program: differential course of neonatal abstinence syndrome.
    Journal of perinatal medicine, 2007, Volume: 35, Issue:4

    Topics: Cohort Studies; Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Methadone; Narc

2007
Variability in the evaluation and management of opiate-exposed newborns in Maryland.
    Clinical pediatrics, 2007, Volume: 46, Issue:7

    Topics: Adolescent; Adult; Data Collection; Female; Humans; Infant, Newborn; Maryland; Methadone; Neonatal A

2007
Intrapartum and postpartum analgesia for women maintained on methadone during pregnancy.
    Obstetrics and gynecology, 2007, Volume: 110, Issue:2 Pt 1

    Topics: Adolescent; Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Case-Control Studies; Cesarean

2007
Using population data to examine the prevalence and correlates of neonatal abstinence syndrome.
    Drug and alcohol review, 2007, Volume: 26, Issue:5

    Topics: Adult; Cross-Sectional Studies; Databases, Factual; Female; Gravidity; Humans; Infant, Newborn; Inte

2007
Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)- and racemic-methadone.
    International journal of clinical pharmacology and therapeutics, 2007, Volume: 45, Issue:7

    Topics: Adult; Alleles; Analgesics, Opioid; Cytochrome P-450 CYP2D6; Female; Genotype; Humans; Male; Methado

2007
Rooming-in compared with standard care for newborns of mothers using methadone or heroin.
    Canadian family physician Medecin de famille canadien, 2007, Volume: 53, Issue:10

    Topics: Adult; Breast Feeding; British Columbia; Child Custody; Cohort Studies; Comorbidity; Female; Heroin;

2007
[The effect of substitution therapy on the birth weight of the newborn, its postpartum adaptation, trophic and course of the neonatal abstinence syndrome].
    Ceska gynekologie, 2007, Volume: 72, Issue:4

    Topics: Apgar Score; Birth Weight; Buprenorphine; Female; Fetal Growth Retardation; Heroin Dependence; Human

2007
Hospital morphine preparation for abstinence syndrome in newborns exposed to buprenorphine or methadone.
    Pharmacy world & science : PWS, 2008, Volume: 30, Issue:3

    Topics: Buprenorphine; Chromatography, High Pressure Liquid; Drug Contamination; Drug Stability; Female; Hum

2008
Outcomes of neonates conceived on methadone maintenance therapy.
    Journal of substance abuse treatment, 2008, Volume: 35, Issue:2

    Topics: Adult; Analgesics, Opioid; Birth Weight; Female; Follow-Up Studies; Gestational Age; Humans; Infant,

2008
Transfer of methadone across the dually perfused preterm human placental lobule.
    American journal of obstetrics and gynecology, 2008, Volume: 198, Issue:1

    Topics: Female; Gestational Age; Humans; Maternal-Fetal Exchange; Methadone; Organ Culture Techniques; Perfu

2008
Methadone maintenance and breastfeeding in the neonatal period.
    Pediatrics, 2008, Volume: 121, Issue:1

    Topics: Adult; Bottle Feeding; Breast Feeding; Case-Control Studies; Cohort Studies; Dose-Response Relations

2008
Visual evoked potentials in infants exposed to methadone in utero.
    Archives of disease in childhood, 2008, Volume: 93, Issue:9

    Topics: Case-Control Studies; Child Development; Evoked Potentials, Visual; Female; Humans; Infant, Newborn;

2008
Buprenorphine and methadone treatment of opiate dependence during pregnancy: comparison of fetal growth and neonatal outcomes in two consecutive case series.
    Drug and alcohol dependence, 2008, Jul-01, Volume: 96, Issue:1-2

    Topics: Birth Weight; Buprenorphine; Female; Fetal Growth Retardation; Heroin Dependence; Humans; Infant Mor

2008
Methadone maintenance and breastfeeding in the neonatal period.
    Pediatrics, 2008, Volume: 121, Issue:4

    Topics: Bottle Feeding; Breast Feeding; Dose-Response Relationship, Drug; Drug Administration Schedule; Fema

2008
Oxygen consumption in the new-born rat and the effects of maternally administered analgesics.
    British journal of pharmacology and chemotherapy, 1967, Volume: 30, Issue:3

    Topics: Analgesics; Animals; Animals, Newborn; Female; Maternal-Fetal Exchange; Meperidine; Methadone; Morph

1967
Narcotics and medical practice. Medical use of morphine and morphine-like drugs and management of persons dependent on them.
    JAMA, 1967, Oct-16, Volume: 202, Issue:3

    Topics: Amphetamine; Barbiturates; Cannabis; Drug and Narcotic Control; Female; Heroin; Humans; Legislation,

1967
Delays in growth and biochemical development of rat brain caused by maternal methadone administration: are the alterations in synaptogenesis and cellular maturation independent of reduced maternal food intake?
    Developmental neuroscience, 1982, Volume: 5, Issue:1

    Topics: Aging; Animals; Body Weight; Brain; Eating; Female; Methadone; Organ Size; Ornithine Decarboxylase;

1982
Chronic use of opioids and antipsychotic drugs: side effects, effects on endogenous opioids, and toxicity.
    Annals of the New York Academy of Sciences, 1982, Volume: 398

    Topics: Adolescent; Adult; Animals; Antipsychotic Agents; Blood Proteins; Endorphins; Female; Humans; Liver

1982
Analgesic effect of opiates in offspring of opiate-treated female rats.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 21, Issue:4

    Topics: Analgesics, Opioid; Animals; Female; Male; Methadone; Morphine; Pregnancy; Prenatal Exposure Delayed

1984
Follow-up of methadone-treated and untreated narcotic-dependent women and their infants: health, developmental, and social implications.
    The Journal of pediatrics, 1981, Volume: 98, Issue:5

    Topics: Adult; Developmental Disabilities; Female; Follow-Up Studies; Health Status; Humans; Infant; Infant,

1981
Children of methadone-maintained mothers: follow-up to 18 months of age.
    The Journal of pediatrics, 1982, Volume: 101, Issue:2

    Topics: Abnormalities, Drug-Induced; Developmental Disabilities; Female; Follow-Up Studies; Humans; Infant;

1982
Maturation of sympathetic neurotransmission in the rat heart. I. Ontogeny of the synaptic vesicle uptake mechanism and correlation with development of synaptic function. Effects of neonatal methadone administration on development of synaptic vesicles.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 212, Issue:1

    Topics: Adrenergic Fibers; Age Factors; Animals; Female; Heart; Heart Rate; Methadone; Norepinephrine; Pregn

1980
Urinary catecholamines, plasma renin activity and blood pressure in newborns: effects of narcotic withdrawal.
    Developmental pharmacology and therapeutics, 1981, Volume: 3, Issue:2

    Topics: Catecholamines; Diastole; Female; Heroin; Humans; Hypertension; Infant, Newborn; Infant, Newborn, Di

1981
Maternal methadone administration: deficit in development of alpha-noradrenergic responses in developing rat brain as assessed by norepinephrine stimulation of 33Pi incorporation into phospholipids in vivo.
    Biochemical pharmacology, 1982, May-15, Volume: 31, Issue:10

    Topics: Animals; Animals, Newborn; Brain; Female; Maternal-Fetal Exchange; Methadone; Norepinephrine; Phosph

1982
Evidence for hormonal imbalance after methadone treatment in pregnant and pseudopregnant rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1983, Volume: 173, Issue:3

    Topics: Adrenal Glands; Animals; Cyclic AMP; Cyclic GMP; Estriol; Female; Fetus; Gestational Age; Methadone;

1983
In utero exposure to methadone produces a stable decrease of the cortex 5-HT transport system in rats.
    European journal of pharmacology, 1983, May-20, Volume: 90, Issue:1

    Topics: Animals; Biological Transport; Cerebral Cortex; Female; Imipramine; Methadone; Naloxone; Pregnancy;

1983
Acute and subchronic effects of methadone on the blood hormonal levels of pregnant and nonpregnant Charles River CD-1 mice.
    Pediatric pharmacology (New York, N.Y.), 1983, Volume: 3, Issue:2

    Topics: Adrenocorticotropic Hormone; Animals; Estriol; Estrus; Female; Follicle Stimulating Hormone; Gestati

1983
Somatic and neurobiological alterations in the progeny of female rats treated with methadone prior to mating.
    NIDA research monograph, 1983, Volume: 43

    Topics: Animals; Body Weight; Brain; Cerebellum; Female; Male; Methadone; Organ Size; Pregnancy; Prenatal Ex

1983
Motoric and attentional behavior in infants of methadone-maintained women.
    NIDA research monograph, 1983, Volume: 43

    Topics: Aging; Attention; Behavior; Female; Humans; Infant; Male; Methadone; Motor Activity; Opioid-Related

1983
Prevalence and implications of multi-drug abuse in a population of methadone-maintained women.
    NIDA research monograph, 1983, Volume: 43

    Topics: Amphetamine; Diazepam; Female; Heroin; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregn

1983
Perinatal addiction: the effects of maternal narcotic and nonnarcotic substance abuse on the fetus and neonate.
    NIDA research monograph, 1984, Volume: 49

    Topics: Adult; Arousal; Birth Weight; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, D

1984
Fetal breathing movements and the response to carbon dioxide in patients on methadone maintenance.
    American journal of obstetrics and gynecology, 1984, Oct-15, Volume: 150, Issue:4

    Topics: Carbon Dioxide; Female; Fetus; Humans; Methadone; Movement; Opioid-Related Disorders; Pregnancy; Pre

1984
A longitudinal study of offspring born to methadone-maintained women. I. Design, methodology, and description of women's resources for functioning.
    The American journal of drug and alcohol abuse, 1984, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Child Behavior; Child Development; Cognition; Family; Female; Follow-Up Studies;

1984
A longitudinal study of offspring born to methadone-maintained women. II. Dyadic interaction and infant behavior at 4 months.
    The American journal of drug and alcohol abuse, 1984, Volume: 10, Issue:2

    Topics: Child Behavior; Child Development; Cognition; Communication; Female; Follow-Up Studies; Heroin Depen

1984
A longitudinal study of offspring born to methadone-maintained women. III. Effects of multiple risk factors on development at 4, 8, and 12 months.
    The American journal of drug and alcohol abuse, 1984, Volume: 10, Issue:2

    Topics: Attention; Child Behavior; Child Development; Female; Follow-Up Studies; Heroin Dependence; Humans;

1984
The Moro reaction: a scoring system for neonatal narcotic withdrawal.
    Developmental medicine and child neurology, 1984, Volume: 26, Issue:4

    Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Pregnancy; Reflex, Startle; S

1984
Dyads at risk: methadone-maintained women and their four-month-old infants.
    Child development, 1984, Volume: 55, Issue:4

    Topics: Adolescent; Adult; Female; Humans; Infant; Longitudinal Studies; Maternal Behavior; Methadone; Mothe

1984
Chronic maternal methadone exposure and response to analgesics.
    Proceedings of the Western Pharmacology Society, 1984, Volume: 27

    Topics: Analgesics; Animals; Brain Chemistry; Female; Male; Methadone; Pregnancy; Prenatal Exposure Delayed

1984
Neonatal opiate withdrawal alters the reactivity of adult rats to the hot-plate.
    Life sciences, 1984, Apr-30, Volume: 34, Issue:18

    Topics: Animals; Dose-Response Relationship, Drug; Escape Reaction; Female; Humans; Male; Methadone; Methady

1984
The sequelea to addiction.
    Critical care update, 1983, Volume: 10, Issue:6

    Topics: Female; Fetal Alcohol Spectrum Disorders; Fetal Diseases; Heroin; Humans; Methadone; Opioid-Related

1983
Methadone affects the histochemical pattern of xenobiotic-metabolizing enzymes in the liver of pregnant rats.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1984, Volume: 7

    Topics: Animals; Female; Histocytochemistry; Liver; Methadone; Mixed Function Oxygenases; Pregnancy; Rats; R

1984
Drug addiction during pregnancy.
    Biological research in pregnancy and perinatology, 1983, Volume: 4, Issue:3

    Topics: Birth Weight; Delivery, Obstetric; Female; Fetal Monitoring; Follow-Up Studies; Heroin; Heroin Depen

1983
Fate of tritium derived from prenatally administered tritiated methadone in dams and neonatal rats.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:6

    Topics: Animals; Animals, Newborn; Brain; Female; Liver; Maternal-Fetal Exchange; Methadone; Pregnancy; Rats

1983
Coordination of services to methadone mothers and their addicted newborns.
    Health & social work, 1983,Fall, Volume: 8, Issue:4

    Topics: Child Abuse; Child Welfare; Child, Preschool; Female; Hospital Departments; Humans; Infant; Infant,

1983
Effects of opiates on fetal behavioral activity in utero.
    Life sciences, 1983, Volume: 33 Suppl 1

    Topics: Animals; Blood Pressure; Female; Fetal Heart; Fetus; Heart Rate; Maternal-Fetal Exchange; Methadone;

1983
Separation of hepatic N-demethylase-inducing and opioid dependence-producing doses of levo-alpha-acetylmethadol in the pregnant rat.
    Life sciences, 1983, Sep-19, Volume: 33, Issue:12

    Topics: Animals; Animals, Newborn; Body Weight; Dose-Response Relationship, Drug; Embryo Implantation; Ethyl

1983
Human garbage and physical garbage: a sociological case example of institutional violence.
    The International journal of the addictions, 1984, Volume: 19, Issue:1

    Topics: Adult; Aged; Delivery of Health Care; Female; Garbage; Humans; Institutional Practice; Israel; Male;

1984
A comprehensive care program for pregnant addicts: obstetrical, neonatal, and child development outcomes.
    The International journal of the addictions, 1984, Volume: 19, Issue:2

    Topics: Adult; Birth Weight; Child Development; Counseling; Delivery, Obstetric; Female; Gestational Age; He

1984
Ventilatory response to carbon dioxide of infants following chronic prenatal methadone exposure.
    The Journal of pediatrics, 1980, Volume: 96, Issue:6

    Topics: Carbon Dioxide; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Methadone; Oxygen; Partial

1980
A quantitative evaluation of fetal growth failure in a drug-abusing population.
    NIDA research monograph, 1981, Volume: 34

    Topics: Abnormalities, Drug-Induced; Female; Fetal Growth Retardation; Gestational Age; Humans; Methadone; P

1981
Altered respiratory control in newborn puppies after chronic prenatal exposure to alpha-1-acetylmethadol (LAAM).
    Respiration physiology, 1982, Volume: 47, Issue:3

    Topics: Animals; Animals, Newborn; Carbon Dioxide; Chloral Hydrate; Dogs; Female; Humans; Methadone; Methady

1982
Differential motor and state functioning in newborns of women on methadone.
    NIDA research monograph, 1982, Volume: 41

    Topics: Adolescent; Adult; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Pregnancy;

1982
The effects of perinatal addiction on pulmonary function in the newborn.
    NIDA research monograph, 1982, Volume: 41

    Topics: Birth Weight; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lung; M

1982
Disposition of maternally-administered methadone and its effects on hepatic drug-metabolizing functions in perinatal guinea pigs.
    Biochemical pharmacology, 1982, Sep-15, Volume: 31, Issue:18

    Topics: Aging; Animals; Animals, Newborn; Blood Proteins; Female; Glucuronosyltransferase; Guinea Pigs; Live

1982
The emergence of maternal drug addiction as a problem in Ireland 1981.
    Irish medical journal, 1983, Volume: 76, Issue:2

    Topics: Adolescent; Adult; Cesarean Section; Female; Heroin; Humans; Infant, Newborn; Ireland; Male; Materna

1983
Fetal and postnatal growth of children born to narcotic-dependent women.
    The Journal of pediatrics, 1983, Volume: 102, Issue:5

    Topics: Body Height; Female; Fetus; Growth; Heroin Dependence; Humans; Infant, Newborn; Longitudinal Studies

1983
[Condition of 89 newborn infants of drug-addicted mothers].
    Ugeskrift for laeger, 1983, Feb-21, Volume: 145, Issue:8

    Topics: Abnormalities, Drug-Induced; Adult; Apgar Score; Female; Heroin Dependence; Humans; Infant, Low Birt

1983
Parental methadone treatment: a multigenerational study of development and behavior in offspring.
    Developmental pharmacology and therapeutics, 1983, Volume: 6, Issue:2

    Topics: Animals; Behavior, Animal; Birth Weight; Body Weight; Brain; Female; Growth; Growth Disorders; Human

1983
Pentazocine and tripelennamine ('T's and blue's'): effects on the fetus and neonate.
    Developmental pharmacology and therapeutics, 1983, Volume: 6, Issue:3

    Topics: Adult; Female; Fetus; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Opioid-Related

1983
Developmental toxic effect after subcutaneous injections of methadone in Charles River CD-1 mice.
    Drug and chemical toxicology, 1983, Volume: 6, Issue:1

    Topics: Animals; Body Weight; Feeding Behavior; Female; Fetus; Growth; Injections, Subcutaneous; Male; Metha

1983
Investigation of 89 children born by drug-dependent mothers. I. Neonatal course.
    Acta paediatrica Scandinavica, 1983, Volume: 72, Issue:3

    Topics: Adult; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Infant, Small

1983
Investigation of 89 children born by drug-dependent mothers. II. Follow-up 1-10 years after birth.
    Acta paediatrica Scandinavica, 1983, Volume: 72, Issue:3

    Topics: Adult; Child; Child Behavior Disorders; Child, Institutionalized; Child, Preschool; Female; Follow-U

1983
Postnatal abstinence or acute toxicity can account for morbidity in developmental studies with opiates.
    Life sciences, 1983, Sep-19, Volume: 33, Issue:12

    Topics: Animals; Animals, Newborn; Body Weight; Dose-Response Relationship, Drug; Embryo, Mammalian; Female;

1983
Influence of concurrent testosterone on the effects of methadone on male rats and their progeny.
    Developmental pharmacology and therapeutics, 1980, Volume: 1, Issue:2-3

    Topics: Animals; Birth Weight; Body Weight; Female; Fetus; Genitalia, Male; Litter Size; Male; Methadone; Pr

1980
Isotope dilution technique for the estimation of l-alpha-[2-3H]-acetylmethadol and its metabolites in biological samples.
    Pharmacology, 1980, Volume: 20, Issue:3

    Topics: Animals; Biotransformation; Chromatography, Gas; Chromatography, Thin Layer; Female; Liver; Methadon

1980
Precocious development of sympatho-adrenal function in rats whose mothers received methadone.
    Life sciences, 1980, May-19, Volume: 26, Issue:20

    Topics: Adrenal Glands; Animals; Catecholamines; Female; Insulin; Maternal-Fetal Exchange; Methadone; Pregna

1980
Duration of thrombocytosis in infants of polydrug (including methadone) users.
    The Journal of pediatrics, 1982, Volume: 100, Issue:3

    Topics: Female; Humans; Infant; Infant, Newborn; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy C

1982
Cumulation of active metabolites of levo-alpha-acetylmethadol in the rat fetus and neonate.
    Life sciences, 1982, Jan-18, Volume: 30, Issue:3

    Topics: Animals; Animals, Newborn; Brain; Female; Fetus; Maternal-Fetal Exchange; Methadone; Methadyl Acetat

1982
Ritalin: consequences of abuse in a clinical population.
    The International journal of the addictions, 1982, Volume: 17, Issue:2

    Topics: Adult; Female; Humans; Injections, Intravenous; Male; Methadone; Methylphenidate; Opioid-Related Dis

1982
The relationship between maternal and fetal plasma protein binding of methadone in the ewe during the third trimester.
    Life sciences, 1982, Apr-12, Volume: 30, Issue:15

    Topics: Animals; Blood Proteins; Female; Fetus; Gestational Age; Maternal-Fetal Exchange; Methadone; Pregnan

1982
A comparison of morphine and methadone disposition in the maternal-fetal unit.
    American journal of obstetrics and gynecology, 1982, Jul-15, Volume: 143, Issue:6

    Topics: Animals; Female; Fetus; Gestational Age; Maternal-Fetal Exchange; Metabolic Clearance Rate; Methadon

1982
Methadone outcome studies: is it more than the methadone?
    The Journal of pediatrics, 1982, Volume: 101, Issue:2

    Topics: Abnormalities, Drug-Induced; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Met

1982
Polydrug- and methadone-addicted newborns: a continuum of impairment?
    Pediatrics, 1982, Volume: 70, Issue:2

    Topics: Abnormalities, Drug-Induced; Birth Weight; Child Behavior; Female; Heroin Dependence; Humans; Infant

1982
The Northwestern University Drug Dependence Program: the impact of intensive prenatal care on labor and delivery outcomes.
    American journal of obstetrics and gynecology, 1982, Sep-01, Volume: 144, Issue:1

    Topics: Adult; Apgar Score; Birth Weight; Cephalometry; Counseling; Female; Fetus; Gestational Age; Humans;

1982
Some effects of maternal drug addiction on the neonate.
    The International journal of the addictions, 1982, Volume: 17, Issue:5

    Topics: Arousal; Child Behavior; Female; Habituation, Psychophysiologic; Heroin; Humans; Infant, Newborn; Ma

1982
Neuronal cell deficits following exposure to methadone in rats.
    Experientia, 1982, Oct-15, Volume: 38, Issue:10

    Topics: Animals; Cell Count; Cerebellum; Female; Lactation; Maternal-Fetal Exchange; Methadone; Neurons; Pre

1982
Infants born to narcotic-addicted mothers.
    Psychological bulletin, 1982, Volume: 92, Issue:2

    Topics: Child Development; Female; Heroin; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Metha

1982
Norepinephrine content of the rat kidney during development: alterations induced by perinatal methadone.
    Life sciences, 1982, Dec-27, Volume: 31, Issue:26

    Topics: Animals; Animals, Newborn; Body Weight; Female; Kidney; Methadone; Norepinephrine; Organ Size; Pregn

1982
Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment.
    Toxicology letters, 1982, Volume: 14, Issue:3-4

    Topics: Aging; Animals; Animals, Newborn; Female; Heart; Methadone; Myocardium; Ornithine Decarboxylase; Pol

1982
Effects of methadone on thyroid function in mother, fetus, and newborn.
    Pediatrics, 1980, Volume: 65, Issue:3

    Topics: Adolescent; Adult; Age Factors; Female; Fetal Blood; Humans; Infant, Newborn; Infant, Newborn, Disea

1980
Sudden infant death.
    Scientific American, 1980, Volume: 242, Issue:4

    Topics: Adipose Tissue; Adipose Tissue, Brown; Carotid Body; Erythrocytes, Abnormal; Female; Humans; Hypoxia

1980
Fetal exposure to narcotics: neonatal sleep as a measure of nervous system disturbance.
    Science (New York, N.Y.), 1980, Aug-01, Volume: 209, Issue:4456

    Topics: Birth Weight; Female; Heroin; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases;

1980
Methadone exposure in utero: effects on open-field activity in weanling rats.
    The International journal of neuroscience, 1980, Volume: 11, Issue:4

    Topics: Animals; Animals, Suckling; Birth Weight; Dose-Response Relationship, Drug; Exploratory Behavior; Fe

1980
Methadone binding to orosomucoid (alpha 1-acid glycoprotein): determinant of free fraction in plasma.
    Clinical pharmacology and therapeutics, 1981, Volume: 29, Issue:2

    Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Lipoproteins; Metabolic Clearance Rate; Methadone; Mid

1981
Opiate withdrawal in utero increases neonatal morbidity in the rat.
    Science (New York, N.Y.), 1981, May-22, Volume: 212, Issue:4497

    Topics: Animals; Drug Tolerance; Embryo Implantation; Female; Fetal Death; Humans; Litter Size; Methadone; M

1981
Outcome of pregnancy in rats chronically exposed to 1-alpha-acetylmethadol (LAAM).
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 218, Issue:2

    Topics: Animals; Animals, Newborn; Birth Weight; Body Weight; Female; Humans; Methadone; Methadyl Acetate; O

1981
Methadone exposure in utero: effects on brain biogenic amines and behavior.
    Neurobehavioral toxicology, 1980,Summer, Volume: 2, Issue:2

    Topics: Animals; Avoidance Learning; Behavior, Animal; Biogenic Amines; Brain Chemistry; Catecholamines; Dop

1980
Withdrawal-like symptoms in young and adult rats maternally exposed to methadone.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 15, Issue:6

    Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Body Temperature Regulation; Body Weight;

1981
[Pregnancy in heroin addiction; an 11-year survey at the Wilhelmina Gasthuis in Amsterdam].
    Nederlands tijdschrift voor geneeskunde, 1982, Feb-20, Volume: 126, Issue:8

    Topics: Female; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn; Infant, Premature; Infant, Sma

1982
Moods of pregnant and nonpregnant heroin addicts.
    The International journal of the addictions, 1980, Volume: 15, Issue:8

    Topics: Adult; Affect; Female; Heroin Dependence; Humans; Methadone; Pregnancy

1980
[Neonatal withdrawal syndrome 2 cases of newborn infants of drug-addicted mothers].
    Minerva pediatrica, 1980, Nov-30, Volume: 32, Issue:22

    Topics: Adult; Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Pregnancy; Substance Withdrawa

1980
Respiratory and hemodynamic effects of methadone in pregnant women.
    Respiration physiology, 1980, Volume: 42, Issue:3

    Topics: Blood Pressure; Female; Heroin Dependence; Humans; Mathematics; Methadone; Oxygen Consumption; Physi

1980
Disposition of methadone in the ovine maternal-fetal unit.
    Life sciences, 1981, May-11, Volume: 28, Issue:19

    Topics: Animals; Female; Maternal-Fetal Exchange; Methadone; Pregnancy; Sheep

1981
Heroin addiction and pregnancy.
    The Western journal of medicine, 1981, Volume: 134, Issue:6

    Topics: Animals; Female; Fetal Diseases; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseas

1981
Enhanced sensitivity to methadone in adult rats perinatally exposed to methadone.
    Life sciences, 1981, Sep-14, Volume: 29, Issue:11

    Topics: Animals; Body Temperature Regulation; Body Weight; Female; Lactation; Methadone; Nociceptors; Pregna

1981
Alterations in the development of catecholamine turnover induced by perinatal methadone: differences in central vs. peripheral sympathetic nervous systems.
    Life sciences, 1981, Dec-14, Volume: 29, Issue:24

    Topics: Animals; Brain; Catecholamines; Central Nervous System; Female; Kinetics; Methadone; Myocardium; Per

1981
The Neonatal Narcotic Withdrawal Index: a device for the improvement of care in the abstinence syndrome.
    The American journal of drug and alcohol abuse, 1981, Volume: 8, Issue:2

    Topics: Female; Heroin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Opium; Pregnancy; Psy

1981
Relationship of thyroid hormone levels to the severity of the narcotic withdrawal syndrome.
    Developmental pharmacology and therapeutics, 1981, Volume: 3, Issue:4

    Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Pregnancy; Prospective

1981
[Newborn neonatal drug-withdrawal syndrome].
    Harefuah, 1981, Nov-01, Volume: 101, Issue:9

    Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Methadone; Opiu

1981
Protracted analgesia in young and adult rats maternally exposed to methadone.
    Experientia, 1980, Mar-15, Volume: 36, Issue:3

    Topics: Age Factors; Analgesia; Animals; Female; Male; Maternal-Fetal Exchange; Methadone; Pregnancy; Rats;

1980
Effects of maternal methadone administration on ornithine decarboxylase in brain and heart of the offspring: relationships of enzyme activity to dose and to growth impairment in the rat.
    Life sciences, 1980, Mar-17, Volume: 26, Issue:11

    Topics: Animals; Body Weight; Brain; Carboxy-Lyases; Female; Heart; Maternal-Fetal Exchange; Methadone; Myoc

1980
[Jaundice in the newborn infant of a "poly-drug-dependent" mother. Heroin and methadone, G6PDH deficiency and antagonism in the enzymatic modulation].
    Minerva pediatrica, 1980, Apr-15, Volume: 32, Issue:7

    Topics: Adult; Drug Antagonism; Female; Glucosephosphate Dehydrogenase Deficiency; Heroin Dependence; Humans

1980
Effect of methadone treatment during pregnancy on the fetal testes and hypothalamus in rats.
    Biology of reproduction, 1980, Volume: 22, Issue:3

    Topics: Androstenedione; Animals; Female; Fetal Blood; Fetus; Hypothalamus; Male; Methadone; Naloxone; Pregn

1980
Thrombocytosis in the offspring of female mice receiving DL-methadone.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1980, Volume: 164, Issue:3

    Topics: Animals; Animals, Newborn; Bone Marrow Cells; Disease Models, Animal; Female; Hematopoiesis; Megakar

1980
Body and organ development of young rats maternally exposed to methadone.
    Biology of the neonate, 1980, Volume: 38, Issue:3-4

    Topics: Animals; Body Weight; Female; Fetus; Lactation; Male; Maternal-Fetal Exchange; Methadone; Organ Size

1980
Effect of maternally administered methadone on discrimination learning of rat offspring.
    Perceptual and motor skills, 1980, Volume: 50, Issue:3 Pt 2

    Topics: Animals; Discrimination Learning; Female; Male; Maternal-Fetal Exchange; Methadone; Pregnancy; Rats

1980
Early growth patterns of methadone-addicted infants.
    American journal of diseases of children (1960), 1980, Volume: 134, Issue:11

    Topics: Adult; Female; Follow-Up Studies; Growth; Humans; Infant, Newborn; Methadone; Pregnancy; Substance W

1980
Effects of prenatal methadone on rat brain catecholamines.
    Developmental neuroscience, 1980, Volume: 3, Issue:4-6

    Topics: Animals; Body Weight; Brain; Catecholamines; Dopamine; Female; Gestational Age; Kinetics; Male; Meth

1980
Developmental outcomes of children of mothers dependent on heroin or heroin/methadone during pregnancy.
    Acta paediatrica (Oslo, Norway : 1992). Supplement, 1994, Volume: 404

    Topics: Child; Child of Impaired Parents; Child, Preschool; Cross-Sectional Studies; Developmental Disabilit

1994
Development after prenatal exposure to cocaine, heroin and methadone.
    Acta paediatrica (Oslo, Norway : 1992). Supplement, 1994, Volume: 404

    Topics: Case-Control Studies; Child; Child of Impaired Parents; Child, Preschool; Cocaine; Developmental Dis

1994
Prenatal care of HIV-infected women: analysis of a large New York State cohort.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1995, Aug-01, Volume: 9, Issue:4

    Topics: Adolescent; Adult; Cohort Studies; Female; HIV Infections; Humans; Infectious Disease Transmission,

1995
Decreased maternal-fetal attachment in methadone-maintained pregnant women: a preliminary study.
    Journal of the Association for Academic Minority Physicians : the official publication of the Association for Academic Minority Physicians, 1995, Volume: 6, Issue:3

    Topics: Adolescent; Adult; Case-Control Studies; Cross-Sectional Studies; Female; Humans; Methadone; Mother-

1995
[Withdrawal syndrome in a newborn infant born to an addicted mother receiving methadone].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1995, Volume: 2, Issue:7

    Topics: Adult; Female; Heroin Dependence; Humans; Infant, Newborn; Male; Methadone; Neonatal Abstinence Synd

1995
Maternal methadone dosage and neonatal withdrawal.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1995, Volume: 35, Issue:2

    Topics: Birth Weight; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Methadone; Neonatal

1995
Children of methadone-dependent women: developmental outcomes.
    The American journal of orthopsychiatry, 1993, Volume: 63, Issue:2

    Topics: Affective Symptoms; Child; Child Behavior Disorders; Child, Preschool; Developmental Disabilities; E

1993
Opioid tolerance in human placenta due to in vitro methadone administration.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 273, Issue:3

    Topics: Chorionic Gonadotropin; Culture Techniques; Drug Tolerance; Female; Humans; Methadone; Narcotics; Pl

1995
Methadone maintenance treatment. Pregnant women taking methadone should be warned about withdrawal symptoms in babies.
    BMJ (Clinical research ed.), 1995, Feb-18, Volume: 310, Issue:6977

    Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Patient

1995
[Substitution treatments in Geneva].
    Annales de medecine interne, 1994, Volume: 145 Suppl 3

    Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Family; Female; HIV Infections; Humans; Male;

1994
[Report on the methadone program at the Centre Pierre-Nicole].
    Annales de medecine interne, 1994, Volume: 145 Suppl 3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Female; Heroin Dependence; Humans; Male; Methadone; Middl

1994
Methadone levels in plasma, urine, and amniotic fluid of methadone-treated pregnant rats.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:4

    Topics: Amniotic Fluid; Animals; Biotransformation; Chromatography, High Pressure Liquid; Emulsions; Female;

1994
The drugs in pregnancy service.
    Addiction (Abingdon, England), 1995, Volume: 90, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Female; Health Behavior; HIV Infections; Humans; Infant, Newborn

1995
Cognitive development at preschool-age of infants of drug-dependent mothers.
    Developmental medicine and child neurology, 1994, Volume: 36, Issue:12

    Topics: Child, Preschool; Cocaine; Cognition; Female; Heroin; Humans; Infant; Infant, Newborn; Language; Mal

1994
[Neonatal abstinence syndrome and maternal toxicological profile].
    Minerva pediatrica, 1994, Volume: 46, Issue:3

    Topics: Dose-Response Relationship, Drug; Female; Gestational Age; Heroin; Humans; Infant, Newborn; Maternal

1994
Children of substance abusers: the life experiences of children of opiate addicts in methadone maintenance.
    The American journal of drug and alcohol abuse, 1994, Volume: 20, Issue:2

    Topics: Adolescent; Adult; Antisocial Personality Disorder; Bipolar Disorder; Child; Child Abuse; Child Abus

1994
Biliary atresia, intestinal malrotation, partial abdominal heterotaxia, and craniofacial anomalies in a newborn with intrauterine opiate exposure.
    Journal of pediatric gastroenterology and nutrition, 1994, Volume: 18, Issue:4

    Topics: Abdomen; Abnormalities, Drug-Induced; Biliary Atresia; Cleft Lip; Cleft Palate; Female; Heroin; Huma

1994
Methadone therapy.
    Lancet (London, England), 1993, May-15, Volume: 341, Issue:8855

    Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Pregnan

1993
HIV infection and the meaning of condoms.
    Culture, medicine and psychiatry, 1993, Volume: 17, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Adult; Condoms; Female; Gender Identity; Health Knowledge, Attit

1993
A comparison of meconium, maternal urine and neonatal urine for detection of maternal drug use during pregnancy.
    Journal of forensic sciences, 1994, Volume: 39, Issue:1

    Topics: Adult; Cocaine; Dronabinol; Female; Gas Chromatography-Mass Spectrometry; Humans; Illicit Drugs; Imm

1994
[Pregnancy test falsely positive from methadone].
    Medicina clinica, 1994, Feb-05, Volume: 102, Issue:4

    Topics: Adult; False Positive Reactions; Female; Humans; Methadone; Pregnancy; Pregnancy Tests

1994
Prenatal exposure to methadone delays the development of striatal cholinergic neurons.
    Brain research. Developmental brain research, 1993, Dec-17, Volume: 76, Issue:2

    Topics: Acetylcholine; Acetylcholinesterase; Animals; Cell Size; Cellular Senescence; Choline O-Acetyltransf

1993
Study of 45 pregnant opiate addicts in Dublin.
    Irish journal of medical science, 1993, Volume: 162, Issue:10

    Topics: Adult; Child Welfare; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Ireland; Life Styl

1993
Relationship of maternal substance abuse to subsequent sudden infant death syndrome in offspring.
    The Journal of pediatrics, 1993, Volume: 123, Issue:1

    Topics: Adult; Age Factors; Chi-Square Distribution; Cocaine; Confidence Intervals; Female; Heroin; Humans;

1993
[The consequences for the child of drug addiction in the mother: current status in relation to knowledge and management policy in The Netherlands].
    Nederlands tijdschrift voor geneeskunde, 1993, Sep-04, Volume: 137, Issue:36

    Topics: Child Development; Child, Preschool; Female; Humans; Infant; Infant Care; Infant, Newborn; Methadone

1993
[Neonatal abstinence syndrome: current and future aspects].
    Revue medicale de Bruxelles, 1993, Volume: 14, Issue:3

    Topics: Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Opium; Parasympatholytics;

1993
Relationship between maternal methadone dosage, maternal-neonatal methadone levels, and neonatal withdrawal.
    Obstetrics and gynecology, 1993, Volume: 81, Issue:6

    Topics: Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Pregnancy; Pregnancy Compl

1993
Perinatal methadone exposure produces physical dependence and altered behavioral development in the rat.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:3

    Topics: Analysis of Variance; Animals; Behavior, Animal; Body Weight; Drinking; Eating; Female; Male; Methad

1996
Methadone use during pregnancy.
    NIDA research monograph, 1995, Volume: 149

    Topics: Animals; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinence Syndrome; Pregna

1995
Perinatal exposure to methadone affects central cholinergic activity in the weanling rat.
    Drug and alcohol dependence, 1996, Volume: 41, Issue:2

    Topics: Acetylcholine; Animals; Animals, Newborn; Brain; Brain Mapping; Female; Humans; Infant, Newborn; Mal

1996
Neonatal withdrawal syndrome in infants exposed to cocaine and methadone.
    Substance use & misuse, 1996, Volume: 31, Issue:2

    Topics: Cocaine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Neurologic Examin

1996
Effects of prenatal exposure to opioids on focused attention in toddlers during free play.
    Journal of developmental and behavioral pediatrics : JDBP, 1996, Volume: 17, Issue:4

    Topics: Attention; Child, Preschool; Female; Heroin; Heroin Dependence; Humans; Male; Methadone; Mother-Chil

1996
Postnatal methadone exposure doe not prevent prenatal methadone-induced changes in striatal cholinergic neurons.
    Brain research. Developmental brain research, 1996, Aug-20, Volume: 95, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; Animals; Dopamine; Female; Hydroxyindoleacetic Acid;

1996
Association of maternal drug use during pregnancy with maternal HIV culture positivity and perinatal HIV transmission.
    AIDS (London, England), 1996, Volume: 10, Issue:3

    Topics: Alcohol Drinking; Cocaine; Cohort Studies; Female; Heroin; HIV Infections; HIV-1; Humans; Infant; In

1996
Effect of methadone on the biophysical profile.
    The Journal of reproductive medicine, 1996, Volume: 41, Issue:11

    Topics: Adult; Circadian Rhythm; Female; Fetal Movement; Heart Rate, Fetal; Humans; Methadone; Opioid-Relate

1996
[Pregnancy and drug dependence].
    Wiener klinische Wochenschrift, 1996, Volume: 108, Issue:19

    Topics: Administration, Oral; Adult; Austria; Delayed-Action Preparations; Dose-Response Relationship, Drug;

1996
Assessment of fetal well-being in methadone-maintained pregnancies: abnormal nonstress tests.
    Gynecologic and obstetric investigation, 1997, Volume: 43, Issue:1

    Topics: Abnormalities, Drug-Induced; Adult; Analgesics, Opioid; Case-Control Studies; Exercise Test; Female;

1997
Association of maternal drug use during pregnancy with mother-to-child HIV transmission. New York City Perinatal HIV Transmission Collaborative Study.
    AIDS (London, England), 1997, Volume: 11, Issue:7

    Topics: Cocaine; Female; Heroin; HIV Infections; Humans; Infant, Newborn; Infectious Disease Transmission, V

1997
Microencephaly and selective decreases in cerebellar Purkinje cell numbers following combined exposure to ethanol and methadone during rat brain development.
    Developmental neuroscience, 1997, Volume: 19, Issue:5

    Topics: Animals; Body Weight; Cell Count; Cell Division; Central Nervous System Depressants; Cerebellum; Dru

1997
Abnormal umbilical artery flow velocity waveform--a sign of fetal narcotic withdrawal?
    The Australian & New Zealand journal of obstetrics & gynaecology, 1997, Volume: 37, Issue:3

    Topics: Adult; Blood Flow Velocity; Cesarean Section; Female; Fetal Growth Retardation; Fetal Monitoring; He

1997
Infants born to narcotic dependent mothers: physical growth patterns in the first 12 months of life.
    Journal of paediatrics and child health, 1997, Volume: 33, Issue:6

    Topics: Adult; Cohort Studies; Female; Fetal Growth Retardation; Growth; Humans; Infant; Infant, Newborn; Me

1997
Neonatal withdrawal following pre- and postnatal exposure to methadone in the rat.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 60, Issue:1

    Topics: Animals; Animals, Newborn; Behavior, Animal; Female; Humans; Infant, Newborn; Male; Methadone; Motor

1998
Effectiveness of CME workshops for alcohol and other drug-related interventions in general practice.
    The Medical journal of Australia, 1998, Jul-20, Volume: 169, Issue:2

    Topics: Accreditation; Alcoholism; Australia; Education, Medical, Continuing; Family Practice; Female; Human

1998
Methadone maintenance in pregnancy: a reappraisal.
    American journal of obstetrics and gynecology, 1998, Volume: 179, Issue:2

    Topics: Adult; Cocaine; Female; Fetus; Humans; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Com

1998
In contrast to cocaine, prenatal exposure to methadone does not produce detectable alterations in the developing mouse brain.
    Brain research. Developmental brain research, 1998, Sep-10, Volume: 110, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Astrocytes; Brain; Cerebral Cortex; Cocaine; Cocaine-Related Disor

1998
Opioid detoxification in pregnancy.
    Obstetrics and gynecology, 1998, Volume: 92, Issue:5

    Topics: Adult; Analgesics; Analgesics, Opioid; Chi-Square Distribution; Clonidine; Drug Therapy, Combination

1998
Unilateral trigeminal and facial nerve palsies associated with epidural analgesia in labour.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:9

    Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, No

1998
Maternal use of heroin and methadone and infant birth weight.
    Addiction (Abingdon, England), 1998, Volume: 93, Issue:9

    Topics: Birth Weight; Female; Heroin Dependence; Humans; Methadone; Narcotics; Pregnancy; Pregnancy Complica

1998
Attachment behavior and its antecedents in offspring born to methadone-maintained women.
    Journal of clinical child psychology, 1999, Volume: 28, Issue:1

    Topics: Adult; Black or African American; Case-Control Studies; Chi-Square Distribution; Child of Impaired P

1999
[Pregnancy, abortion and delivery in a cohort of heroin dependent patients treated with drug substitution (methadone and buprenorphine) in Aquitaine].
    Presse medicale (Paris, France : 1983), 1999, Jan-30, Volume: 28, Issue:4

    Topics: Abortion, Legal; Adult; Buprenorphine; Cohort Studies; Female; France; Heroin Dependence; Humans; Me

1999
Hyperphagia in neonates withdrawing from methadone.
    Archives of disease in childhood. Fetal and neonatal edition, 1999, Volume: 80, Issue:3

    Topics: Adult; Birth Weight; Body Weight; Female; Humans; Hyperphagia; Incidence; Infant, Newborn; Linear Mo

1999
Translating clinical trial results into practice: the effect of an AIDS clinical trial on prescribed antiretroviral therapy for HIV-infected pregnant women.
    Annals of internal medicine, 1999, Jun-15, Volume: 130, Issue:12

    Topics: Adult; Analgesics, Opioid; Anti-HIV Agents; Clinical Protocols; Clinical Trials as Topic; Community

1999
Shorter dosing interval of opiate solution shortens hospital stay for methadone babies.
    Family medicine, 1999, Volume: 31, Issue:5

    Topics: Drug Administration Schedule; Female; Hospitalization; Humans; Infant, Newborn; Length of Stay; Mate

1999
Outcome predictors in pregnant opiate and polydrug users.
    European journal of pediatrics, 1999, Volume: 158, Issue:9

    Topics: Benzodiazepines; Birth Weight; Female; Humans; Infant, Low Birth Weight; Infant, Newborn; Methadone;

1999
Alterations in methadone metabolism during late pregnancy.
    Journal of addictive diseases, 1999, Volume: 18, Issue:4

    Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Half-Life; Humans; Me

1999
Use of methadone.
    The Western journal of medicine, 2000, Volume: 172, Issue:1

    Topics: Analgesics, Opioid; Drug Interactions; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonat

2000
Birth outcome in incarcerated, high-risk pregnant women.
    The Journal of reproductive medicine, 2000, Volume: 45, Issue:3

    Topics: Adult; Female; Humans; Methadone; Narcotics; Pregnancy; Pregnancy Outcome; Pregnancy, High-Risk; Pre

2000
The drug epidemic: effects on newborn infants and health resource consumption at a tertiary perinatal centre.
    Journal of paediatrics and child health, 2000, Volume: 36, Issue:3

    Topics: Adult; Ambulatory Care Facilities; Amphetamines; Australia; Benzodiazepines; Cannabis; Cocaine; Como

2000
[Methadone treatment during pregnancy and its effect on the child. Better than continuing drug abuse, should be monitored by a specialized antenatal care center].
    Lakartidningen, 2000, May-03, Volume: 97, Issue:18

    Topics: Adult; Embryonic and Fetal Development; Female; Heroin Dependence; Humans; Infant, Newborn; Maternal

2000
[Drug dependence in pregnancy. Better to substitute than complete withdrawal].
    MMW Fortschritte der Medizin, 2000, Apr-27, Volume: 142, Issue:17

    Topics: Analgesics, Opioid; Buprenorphine; Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Ne

2000
[The first pregnancy and delivery within the framework of the methadone program in the Czech Republic].
    Ceska gynekologie, 2000, Volume: 65, Issue:4

    Topics: Adult; Czech Republic; Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Pregnancy; Pre

2000
[Postpartum risk factors in the development of children born to opiate-addicted mothers; comparison between mothers with and without methadone substitution].
    Der Nervenarzt, 2000, Volume: 71, Issue:9

    Topics: Adult; Birth Weight; Case-Control Studies; Child Advocacy; Child Development; Female; Germany; Gesta

2000
Treatment of opioid dependence in pregnant women.
    Addiction (Abingdon, England), 2000, Volume: 95, Issue:8

    Topics: Adult; Female; HIV Infections; Humans; Infant, Newborn; Life Style; Methadone; Narcotics; Neonatal A

2000
[Neonatal withdrawal syndrome in twins born to a mother on methadone substitution].
    Annales de medecine interne, 2000, Volume: 151 Suppl B

    Topics: Adult; Diseases in Twins; Female; Follow-Up Studies; Heroin Dependence; Humans; Infant, Newborn; Met

2000
Mothers and methadone.
    The American journal of nursing, 2000, Volume: 100, Issue:12

    Topics: Analgesics, Opioid; Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Neonatal Abstinen

2000
Perinatal opioids reduce striatal nerve growth factor content in rat striatum.
    European journal of pharmacology, 2001, Mar-02, Volume: 414, Issue:2-3

    Topics: Animals; Animals, Newborn; Buprenorphine; Corpus Striatum; Female; Male; Methadone; Narcotics; Nerve

2001
[Opiate dependent pregnant patients and mothers. What must be regarded in drug substitution and detoxification].
    MMW Fortschritte der Medizin, 2001, May-28, Volume: 143 Suppl 2

    Topics: Ambulatory Care; Female; Germany; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome;

2001
[Evaluation of health status in participants from a methadone treatment program in Krakow after one year of maintenance treatment].
    Przeglad lekarski, 2001, Volume: 58, Issue:4

    Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders; Poland; Pregnancy; Pr

2001
Coordinated outpatient care of the narcotic-dependent infant.
    Journal of paediatrics and child health, 2001, Volume: 37, Issue:3

    Topics: Ambulatory Care; Child Health Services; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases;

2001
Methadone and the pregnant user: a matter for careful clinical consideration.
    The Australian & New Zealand journal of obstetrics & gynaecology, 2001, Volume: 41, Issue:3

    Topics: Female; Heroin Dependence; Humans; Maternal Health Services; Methadone; Pregnancy; Pregnancy Complic

2001
Smoking during pregnancy and intention to quit: a profile of methadone-maintained women.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2001, Volume: 3, Issue:4

    Topics: Adult; Attitude to Health; Carbon Monoxide; Cotinine; Ethnicity; Female; Follow-Up Studies; Heroin D

2001
Methadone dependence and its effects on consecutive pregnancies.
    The practising midwife, 2000, Volume: 3, Issue:9

    Topics: Adolescent; Adult; Birth Weight; Dose-Response Relationship, Drug; Female; Fetal Growth Retardation;

2000
Congenital malformations of the central nervous system produced by narcotic analgesics in the hamster.
    American journal of obstetrics and gynecology, 1975, Dec-01, Volume: 123, Issue:7

    Topics: Abnormalities, Drug-Induced; Analgesics, Opioid; Animals; Central Nervous System; Female; Fetal Deat

1975
Pharmacotherapy of narcotic dependence.
    Progress in neuro-psychopharmacology, 1977, Volume: 1, Issue:1-2

    Topics: Buprenorphine; Cyclazocine; Dextropropoxyphene; Diphenoxylate; Female; Humans; Infant, Newborn; Infa

1977
Drug addiction in pregnancy.
    Lancet (London, England), 1976, Oct-23, Volume: 2, Issue:7991

    Topics: Adult; Female; Follow-Up Studies; Heroin; Heroin Dependence; Humans; Infant, Newborn; Infant, Newbor

1976
Late withdrawal symptoms in babies born to methadone addicts.
    Lancet (London, England), 1977, Dec-10, Volume: 2, Issue:8050

    Topics: Adult; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal

1977
The placental transfer and materno-fetal disposition of methadone in monkeys.
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 205, Issue:3

    Topics: Animals; Female; Gestational Age; Haplorhini; Macaca mulatta; Maternal-Fetal Exchange; Methadone; Pr

1978
Motor activity and learning ability in rats perinatally exposed to methadone.
    NIDA research monograph, 1979, Volume: 27

    Topics: Animals; Female; Learning; Male; Maternal-Fetal Exchange; Methadone; Motor Activity; Pregnancy; Rats

1979
Overview: protracted effects of early exposure to drugs of abuse.
    Pharmacology, biochemistry, and behavior, 1979, Volume: 11 Suppl

    Topics: Animals; Female; Growth; Haplorhini; Heroin Dependence; Humans; Methadone; Opioid-Related Disorders;

1979
Palmar crease variants and their clinical significance: a study of newborns at risk.
    Pediatric research, 1977, Volume: 11, Issue:2

    Topics: Adult; Age Factors; Child; Child, Preschool; Dermatoglyphics; Down Syndrome; Female; Fetus; Hand; Hu

1977
Mechanism of action of narcotics in the production of menstrual dysfunction in women.
    Fertility and sterility, 1975, Volume: 26, Issue:6

    Topics: Adult; Amenorrhea; Barbiturates; Central Nervous System; Corpus Luteum; Ethinyl Estradiol; Female; F

1975
Management of pregnant drug-dependent women.
    Annals of the New York Academy of Sciences, 1978, Volume: 311

    Topics: Family Therapy; Female; Heroin Dependence; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant

1978
Perinatal addiction: outcome and management.
    American journal of obstetrics and gynecology, 1977, Nov-15, Volume: 129, Issue:6

    Topics: Abruptio Placentae; Apgar Score; Breech Presentation; Cesarean Section; Counseling; Female; Fetal Gr

1977
Localization of methadone in fetal rat eye by the immunofluorescence technic.
    Experimental eye research, 1977, Volume: 24, Issue:6

    Topics: Animals; Animals, Newborn; Drug Tolerance; Female; Fetus; Fluorescent Antibody Technique; Methadone;

1977
Methadone detection in rat myenteric plexus: comparison with findings in the central nervous system by the immunofluorescence method.
    The International journal of the addictions, 1978, Volume: 13, Issue:7

    Topics: Animals; Central Nervous System; Female; Fluorescent Antibody Technique; Ganglia; Male; Maternal-Fet

1978
[The effect of heroin and methadone on pregnancy and the newborn infant].
    Nederlands tijdschrift voor geneeskunde, 1979, Jul-07, Volume: 123, Issue:27

    Topics: Female; Fetus; Heroin; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Labor,

1979
Perinatal drug abuse.
    Pediatric annals, 1979, Volume: 8, Issue:2

    Topics: Amphetamines; Barbiturates; Cannabis; Cocaine; Female; Fetal Alcohol Spectrum Disorders; Heroin Depe

1979
Imparied thermal regulation in juvenile rats following perinatal methadone exposure.
    Pharmacology, biochemistry, and behavior, 1979, Volume: 10, Issue:4

    Topics: Animals; Animals, Newborn; Body Temperature Regulation; Body Weight; Feeding Behavior; Female; Male;

1979
Prenatal exposure to methadone HCL in relationship to body and brain growth in the rat.
    Acta neurologica Scandinavica, 1979, Volume: 59, Issue:5

    Topics: Age Factors; Animals; Body Weight; Brain; Cell Count; Cerebral Cortex; Female; Fetus; Male; Maternal

1979
Learning ability in adult female rats perinatally exposed to methadone.
    Pharmacology, biochemistry, and behavior, 1979, Volume: 10, Issue:6

    Topics: Animals; Animals, Newborn; Avoidance Learning; Body Weight; Female; Learning; Methadone; Pregnancy;

1979
Cardiac effects of 1-alpha-acetylmethadol (LAAM) in different species.
    General pharmacology, 1979, Volume: 10, Issue:5

    Topics: Animals; Calcium; Depression, Chemical; Drug Interactions; Female; Guinea Pigs; Heart; Heart Rate; I

1979
The congenitally methadone-addicted infant.
    Birth defects original article series, 1979, Volume: 15, Issue:7

    Topics: Child Development; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchan

1979
Outcomes of pregnancy for addicts receiving comprehensive care.
    The American journal of drug and alcohol abuse, 1979, Volume: 6, Issue:4

    Topics: Adult; Bilirubin; Birth Weight; Comprehensive Health Care; Female; Gestational Age; Humans; Infant,

1979
Methadone exposure in utero: developmental status at one and two years of age.
    Pharmacology, biochemistry, and behavior, 1979, Volume: 11 Suppl

    Topics: Aging; Female; Growth; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Intelligence Test

1979
Children of methadone-treated women at five years of age.
    Pharmacology, biochemistry, and behavior, 1979, Volume: 11 Suppl

    Topics: Behavior; Child, Preschool; Cognition; Female; Heroin Dependence; Humans; Male; Mental Processes; Me

1979
Methadone disposition during the perinatal period in humans.
    Pharmacology, biochemistry, and behavior, 1979, Volume: 11 Suppl

    Topics: Adult; Amniotic Fluid; Animals; Biotransformation; Female; Fetal Blood; Gestational Age; Humans; Inf

1979
Effects of prenatal methadone on the rest-activity cycle of the pre-weanling rat.
    Neurobehavioral toxicology, 1979,Spring, Volume: 1, Issue:1

    Topics: Aging; Animals; Female; Methadone; Motor Activity; Pregnancy; Rats; Sleep; Time Factors

1979
Behavioral effects of fetal and neonatal exposure to methadone in the rat.
    Neurobehavioral toxicology, 1979,Spring, Volume: 1, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Body Weight; Emotions; Female; Fetus; Growth; Male; Methadone; Pre

1979
Sudden unexpected death in infants of narcotic-dependent mothers.
    Early human development, 1978, Volume: 2, Issue:3

    Topics: Adolescent; Adult; Female; Heroin Dependence; Humans; Infant; Infant, Newborn; Male; Maternal-Fetal

1978
Effect of maternal methadone addiction on offspring in rats.
    Archives internationales de pharmacodynamie et de therapie, 1977, Volume: 228, Issue:2

    Topics: Animals; Birth Weight; Brain; Brain Chemistry; Female; Humans; Maternal-Fetal Exchange; Methadone; O

1977
Commonly asked clinical questions about methadone maintenance.
    The International journal of the addictions, 1977, Volume: 12, Issue:7

    Topics: Age Factors; Antidepressive Agents; Community Mental Health Services; Comprehensive Health Care; Fac

1977
Blockade of the preovulatory LH surge by methadone in rats.
    Research communications in chemical pathology and pharmacology, 1978, Volume: 19, Issue:3

    Topics: Animals; Depression, Chemical; Female; Luteinizing Hormone; Methadone; Ovulation; Pregnancy; Proestr

1978
Perinatal methadone addiction affects brain synaptic development of biogenic amine systems in the rat.
    Life sciences, 1979, Mar-26, Volume: 24, Issue:13

    Topics: Animals; Animals, Newborn; Biogenic Amines; Body Weight; Brain; Female; Humans; Maternal-Fetal Excha

1979
Narcotic abuse in pregnancy.
    The Journal of family practice, 1979, Volume: 9, Issue:4

    Topics: Adult; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Pre

1979
Morphine and methadone-induced antinociception in rats permanently depleted of brain dopamine.
    Archives internationales de pharmacodynamie et de therapie, 1977, Volume: 229, Issue:2

    Topics: Analgesics; Animals; Brain; Dopamine; Female; Hydroxydopamines; Methadone; Morphine; Norepinephrine;

1977
The narcotic-dependent mother: fetal and neonatal consequences.
    Early human development, 1977, Volume: 1, Issue:2

    Topics: Adult; Female; Fetal Death; Fetus; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn; Inf

1977
Perinatal methadone exposure and brain development: a biochemical study.
    Journal of neurochemistry, 1978, Volume: 31, Issue:1

    Topics: Animals; Body Weight; Brain; Cerebellum; DNA; Female; Lactation; Male; Maternal-Fetal Exchange; Meth

1978
Problems pertaining to the care of newborn infants of drug-addicted women.
    The Journal of reproductive medicine, 1978, Volume: 20, Issue:6

    Topics: Apnea; Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Narcotics; P

1978
Psychosocial care of the pregnant narcotic addict.
    The Journal of reproductive medicine, 1978, Volume: 20, Issue:6

    Topics: Behavior Therapy; Female; Heroin Dependence; Humans; Infant, Low Birth Weight; Infant, Newborn; Infa

1978
Chromosome aberrations in the mother and the newborn from drug-addiction pregnancies.
    The Journal of reproductive medicine, 1978, Volume: 20, Issue:6

    Topics: Blood Cells; Chromatids; Chromosome Aberrations; Female; Heroin Dependence; Humans; Infant, Newborn;

1978
Methadone.
    The Medical journal of Australia, 1978, May-06, Volume: 1, Issue:9

    Topics: Female; Humans; Methadone; Pregnancy; Pregnancy Complications; Substance-Related Disorders

1978
A comparative study on the behavioral response of offspring of female rats chronically treated with methadone and morphine.
    Proceedings of the Western Pharmacology Society, 1978, Volume: 21

    Topics: Animals; Avoidance Learning; Behavior, Animal; Female; Male; Methadone; Morphine; Motor Activity; Pr

1978
Effects of chronic methadone treatment on maternal body weight and food and water consumption in rats.
    Pharmacology, 1978, Volume: 17, Issue:4

    Topics: Animals; Body Weight; Drinking; Eating; Female; Injections, Intraperitoneal; Lactation; Methadone; P

1978
Perinatal methadone exposure in rats. Effects on body and organ development.
    Biology of the neonate, 1978, Volume: 34, Issue:1-2

    Topics: Animals; Animals, Newborn; Body Water; Body Weight; Female; Fetus; Growth; Lactation; Maternal-Fetal

1978
Methadone.
    The Medical journal of Australia, 1978, Sep-09, Volume: 2, Issue:6

    Topics: Female; Heroin Dependence; Humans; Methadone; Pregnancy; Pregnancy Complications

1978
Chronic methadone administration to male rats: tolerance to adverse effects on sires and their progeny.
    Pharmacology, biochemistry, and behavior, 1978, Volume: 9, Issue:4

    Topics: Animals; Behavior, Animal; Body Weight; Drug Tolerance; Female; Genes, Dominant; Genes, Lethal; Male

1978
Methadone during pregnancy: assessment of behavioral effects in the rat offspring.
    The Journal of pharmacology and experimental therapeutics, 1979, Volume: 208, Issue:1

    Topics: Animals; Behavior, Animal; Birth Weight; Conditioning, Operant; Discrimination, Psychological; Femal

1979
Fetal consequences of chronic methadone administration to pregnant rats: methadological problems.
    Current therapeutic research, clinical and experimental, 1975, Volume: 17, Issue:3

    Topics: Animals; Animals, Newborn; Birth Weight; Female; Fetus; Humans; Maternal-Fetal Exchange; Methadone;

1975
Observation and treatment of neonatal narcotic withdrawal.
    American journal of obstetrics and gynecology, 1977, Jan-15, Volume: 127, Issue:2

    Topics: Diazepam; Drug Therapy, Combination; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, New

1977
Experiences with 118 infants born to narcotic-using mothers. Does a lowered serum-ionized calcium level contribute to the symptoms of withdrawal?
    Clinical pediatrics, 1977, Volume: 16, Issue:5

    Topics: Calcium; Female; Follow-Up Studies; Heroin Dependence; Humans; Infant, Low Birth Weight; Infant, New

1977
Neonatal withdrawal symptoms associated with glutethimide (Doriden) addiction in the mother during pregnancy.
    Clinical pediatrics, 1977, Volume: 16, Issue:5

    Topics: Female; Glutethimide; Heroin Dependence; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant,

1977
The effects of different schedules of methadone treatment on rat brain development.
    Experimental neurology, 1977, Volume: 56, Issue:3

    Topics: Age Factors; Animals; Body Weight; Brain; Cerebellum; Female; Lactation; Male; Methadone; Organ Size

1977
Control of ventilation in pregnant methadone maintenance subjects.
    Proceedings of the Western Pharmacology Society, 1977, Volume: 20

    Topics: Carbon Dioxide; Drug Tolerance; Female; Humans; Hyperventilation; Male; Methadone; Pregnancy; Respir

1977
The effect of maternally administered methadone on brain development in the offspring.
    The Journal of pharmacology and experimental therapeutics, 1977, Volume: 203, Issue:2

    Topics: Animals; Avoidance Learning; Brain; DNA; Female; Growth; Male; Maternal-Fetal Exchange; Methadone; N

1977
Maternal ingested methadone, body fluid methadone, and the neonatal withdrawal syndrome.
    American journal of obstetrics and gynecology, 1977, Oct-15, Volume: 129, Issue:4

    Topics: Amniotic Fluid; Body Fluids; Female; Fetal Blood; Fetus; Heroin Dependence; Humans; Infant, Newborn;

1977
Effect of chronic maternal methadone exposure on perinatal development.
    Biology of the neonate, 1977, Volume: 31, Issue:5-6

    Topics: Animals; Animals, Newborn; Body Weight; Brain; Cerebellum; Female; Fetus; Male; Maternal-Fetal Excha

1977
Methadone and brain development.
    Experientia, 1977, Nov-15, Volume: 33, Issue:11

    Topics: Animals; Brain; Brain Chemistry; DNA; Female; Gestational Age; Lactation; Maternal-Fetal Exchange; M

1977
Narcotic dependency in pregnancy. Methadone maintenance compared to use of street drugs.
    JAMA, 1976, Mar-15, Volume: 235, Issue:11

    Topics: Adolescent; Adult; Apgar Score; Birth Weight; Child, Preschool; Female; Follow-Up Studies; Heroin De

1976
Amniotic fluid and fetal maturity.
    The Journal of reproductive medicine, 1976, Volume: 16, Issue:1

    Topics: Amniotic Fluid; Female; Humans; Lung; Methadone; Phosphatidylcholines; Pregnancy; Pulmonary Surfacta

1976
Behavioural concomitants of prenatal addiction to narcotics.
    The Journal of pediatrics, 1976, Volume: 89, Issue:5

    Topics: Child Development; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Feta

1976
Tissue distribution of levo-methadone in nonpregnant and pregnant female and male mice: effect of SKF 525-A 1,2.
    The Journal of pharmacology and experimental therapeutics, 1976, Volume: 199, Issue:1

    Topics: Animals; Dealkylation; Female; Fetus; Male; Methadone; Mice; Organ Specificity; Pregnancy; Proadifen

1976
Effects of neonatal or maternal methadone administration on ornithine decarboxylase activity in brain and heart of developing rats.
    The Journal of pharmacology and experimental therapeutics, 1976, Volume: 199, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Body Weight; Brain; Carboxy-Lyases; Female; Heart; Methadone; Myoc

1976
Effects of methadone hydrochloride on the growth of organotypic cerebellar cultures prepared from methadone-tolerant and control rats.
    The Journal of pharmacology and experimental therapeutics, 1976, Volume: 199, Issue:2

    Topics: Animals; Animals, Newborn; Cells, Cultured; Cerebellum; Drug Tolerance; Female; Male; Maternal-Fetal

1976
Differential effects of maternal heroin and methadone use on birthweight.
    Pediatrics, 1976, Volume: 58, Issue:5

    Topics: Adult; Birth Weight; Dose-Response Relationship, Drug; Ethnicity; Female; Gestational Age; Heroin; H

1976
Neonatal drug dependence: developmental and bio-cultural considerations.
    Addictive diseases, 1976, Volume: 2, Issue:4

    Topics: Birth Weight; Family Characteristics; Female; Fetus; Humans; Infant Mortality; Infant, Newborn; Infa

1976
Urinary amine alterations in drug-addiction pregnancy.
    American journal of obstetrics and gynecology, 1976, Dec-01, Volume: 126, Issue:7

    Topics: Adolescent; Adult; Epinephrine; Female; Heroin; Humans; Methadone; Norepinephrine; Pregnancy; Pregna

1976
Relationship of neonatal withdrawal to maternal methadone dose.
    The American journal of drug and alcohol abuse, 1976, Volume: 3, Issue:2

    Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Preg

1976
Heroin addiction, methadone maintenance, and pregnancy.
    The Journal of the American Osteopathic Association, 1976, Volume: 75, Issue:9

    Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Nutritional Physiological Phenomena;

1976
Methadone maintenance: it ain't what it used to be.
    The British journal of addiction to alcohol and other drugs, 1976, Volume: 71, Issue:2

    Topics: Attitude of Health Personnel; Evaluation Studies as Topic; Female; Fetus; Heroin Dependence; Humans;

1976
Results of 313 consecutive live births of infants delivered to patients in the New York City Methadone Maintenance Treatment Program.
    American journal of obstetrics and gynecology, 1975, Jan-15, Volume: 121, Issue:2

    Topics: Adolescent; Adult; Apgar Score; Birth Weight; Drug and Narcotic Control; Female; Fetus; Follow-Up St

1975
Methadone assays in pregnant women and progeny.
    American journal of obstetrics and gynecology, 1975, Mar-01, Volume: 121, Issue:5

    Topics: Amniotic Fluid; Chromatography, Gas; Female; Fetus; Heroin Dependence; Humans; Infant, Newborn; Infa

1975
Observations on methadone withdrawal in 16 neonates.
    Clinical pediatrics, 1975, Volume: 14, Issue:4

    Topics: Adolescent; Adult; Birth Weight; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn

1975
Development of a "blood-brain barrier" to methadone in the newborn rat.
    The Journal of pharmacology and experimental therapeutics, 1975, Volume: 192, Issue:3

    Topics: Animals; Animals, Newborn; Blood-Brain Barrier; Brain; Brain Chemistry; Female; Fetus; Male; Materna

1975
Fetal stress from methadone withdrawal.
    American journal of obstetrics and gynecology, 1975, May-01, Volume: 122, Issue:1

    Topics: Adrenal Glands; Amniocentesis; Amniotic Fluid; Epinephrine; Female; Fetus; Heroin Dependence; Humans

1975
Guidelines for the management of hospitalized narcotics addicts.
    Annals of internal medicine, 1975, Volume: 82, Issue:6

    Topics: Analgesia; Drug Administration Schedule; Drug Combinations; Drug Interactions; Female; Heroin; Hospi

1975
Intrapartum gonococcal amnionitis.
    American journal of obstetrics and gynecology, 1975, Feb-15, Volume: 121, Issue:4

    Topics: Acute Disease; Adult; Amnion; Apgar Score; Female; Gonorrhea; Heroin Dependence; Humans; Infant, New

1975
Multiple births in drug-addicted women.
    American journal of obstetrics and gynecology, 1975, Aug-15, Volume: 122, Issue:8

    Topics: Adult; Female; Heroin; Heroin Dependence; Humans; Infant, Newborn; Male; Methadone; Ovulation; Pregn

1975
Acute management of neonatal addiction.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Antidiarrheals; Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant

1975
Disposition of methadone and its relationship to severity of withdrawal in the newborn.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Administration, Oral; Chromatography, Gas; Dose-Response Relationship, Drug; Female; Fetal Blood; Ha

1975
A study of factors that influence the severity of neonatal narcotic withdrawal.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Administration, Oral; Bilirubin; Birth Weight; Body Weight; Dose-Response Relationship, Drug; Enviro

1975
Current concepts in the management of the pregnant opiate addict.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Administration, Oral; Anesthesia, Conduction; Anesthesia, Obstetrical; Birth Weight; Counseling; Fem

1975
Neurological aspects of perinatal narcotic addiction and methadone treatment.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Auditory Perception; Autonomic Nervous System; Birth Weight; Central Nervous System Diseases; Child

1975
Part II. Behavioral and electrophysiological characteristics of the addicted neonate.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Acoustic Stimulation; Arousal; Attention; Birth Weight; Electrophysiology; Evoked Potentials; Female

1975
Neonatal addiction: a two-year study. Part I. Clinical and developmental characteristics of infants of mothers on methadone maintenance.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Administration, Oral; Age Factors; Attention; Birth Weight; Child Development; Diazepam; Dose-Respon

1975
Somatic growth effects of perinatal addiction.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Birth Weight; Cephalometry; Child; Child Development; Child Nutritional Physiological Phenomena; Chi

1975
Differential effects of heroin and methadone on birth weights.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Birth Weight; Dose-Response Relationship, Drug; Female; Fetus; Gestational Age; Heroin Dependence; H

1975
Cytogenetic risks to the offspring of pregnant addicts.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Chromosome Aberrations; Female; Fetus; Heroin Dependence; Humans; Infant, Newborn; Karyotyping; Male

1975
Heat-stable alkaline phosphatase in methadone-maintained pregnancies.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Administration, Oral; Alkaline Phosphatase; Female; Fetal Blood; Gestational Age; Heroin Dependence;

1975
Philadelphia's community based drug abuse program: broader medical and social concepts.
    International journal of clinical pharmacology and biopharmacy, 1975, Volume: 11, Issue:4

    Topics: Alcoholism; Community Mental Health Services; Counseling; Female; Heroin Dependence; Humans; Male; M

1975
Effect of maternal heroin addiction on 67 liveborn neonates. Withdrawal symptoms, small body size, and small head circumference were frequent findings.
    Clinical pediatrics, 1975, Volume: 14, Issue:8

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Birth Weight; Blood Glucose; Cephalomet

1975
The effects of methadone on maternal-fetal interactions in the rat.
    The Journal of pharmacology and experimental therapeutics, 1975, Volume: 192, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Dose-Response Relationship, Drug; Female; Fetal D

1975
Clinical observations on methadone-maintained pregnancies.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Administration, Oral; Adult; Birth Weight; Counseling; Dose-Response Relationship, Drug; Female; Fet

1975
Narcotic addiction in the newborn: differences in behavior generated by methadone and heroin.
    International journal of clinical pharmacology and biopharmacy, 1975, Volume: 12, Issue:1-2

    Topics: Adaptation, Physiological; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, New

1975
Comparison of eight kits for the diagnosis of pregnancy.
    American journal of clinical pathology, 1975, Volume: 64, Issue:4

    Topics: Chlorpromazine; Chorionic Gonadotropin; Evaluation Studies as Topic; False Negative Reactions; False

1975
Behavior of narcotics-addicted newborns.
    Child development, 1975, Volume: 46, Issue:4

    Topics: Adult; Attention; Female; Habituation, Psychophysiologic; Heroin; Humans; Infant, Newborn; Infant, N

1975
Brain concentration of methadone after administration of 14C labelled dl-methadone to pregnant rats by different routes.
    Proceedings of the Western Pharmacology Society, 1975, Volume: 18

    Topics: Administration, Oral; Animals; Brain; Duodenum; Female; Fetus; Injections; Injections, Intraperitone

1975
Neonatal narcotic abstinence: Effects of pharmacotherapeutic agents and maternal drug usage on nutritive sucking behavior.
    The Journal of pediatrics, 1976, Volume: 88, Issue:4 Pt 1

    Topics: Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Opium; Phenob

1976
A study of factors that influence the severity of neonatal narcotic withdrawal.
    The Journal of pediatrics, 1976, Volume: 88, Issue:4 Pt 1

    Topics: Apgar Score; Female; Gestational Age; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lighting;

1976
Cytogenetics of methadone-managed and heroin-addicted pregnant women and their newborn infants.
    American journal of obstetrics and gynecology, 1976, Mar-15, Volume: 124, Issue:6

    Topics: Adolescent; Adult; Apgar Score; Chromosome Aberrations; Female; Fetal Blood; Heroin Dependence; Huma

1976
The effect of methadone on fetal brain function.
    American journal of obstetrics and gynecology, 1976, Apr-01, Volume: 124, Issue:7

    Topics: Animals; Brain; Carotid Arteries; Female; Fetal Heart; Fetus; Heart Rate; Methadone; Pregnancy; Regi

1976
Methadone during pregnancy in the rat: dose level effects on maternal and perinatal mortality and growth in the offspring.
    The Journal of pharmacology and experimental therapeutics, 1976, Volume: 197, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Birth Weight; Body Weight; Female; Fetal Death; Fetus; Gestati

1976
Sub-lethal effects on offspring of male rats treated with methadone before mating.
    Research communications in chemical pathology and pharmacology, 1976, Volume: 13, Issue:4

    Topics: Animals; Birth Weight; Body Weight; Female; Fertility; Growth; Male; Methadone; Pregnancy; Rats; Sex

1976
Drug addiction in pregnancy and the neonate.
    American journal of obstetrics and gynecology, 1976, May-15, Volume: 125, Issue:2

    Topics: Alcoholic Intoxication; Birth Weight; Diazepam; Female; Heroin Dependence; Hospitalization; Humans;

1976
Pharmacologic observations on the neonatal withdrawal syndrome.
    The Journal of pediatrics, 1976, Volume: 88, Issue:6

    Topics: Female; Half-Life; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Kinetics;

1976
Establishment of a liaison service for pregnant opiate-dependent women.
    British journal of addiction, 1992, Volume: 87, Issue:6

    Topics: Adolescent; Adult; Behavior, Addictive; England; Female; Health Promotion; HIV Infections; Humans; I

1992
Narcotic addiction in pregnancy with adverse maternal and perinatal outcome.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1992, Volume: 32, Issue:3

    Topics: Adult; Female; Fetal Growth Retardation; Heroin Dependence; Hong Kong; Humans; Infant, Low Birth Wei

1992
Improving treatment outcome in pregnant opiate-dependent women.
    Journal of substance abuse treatment, 1992,Fall, Volume: 9, Issue:4

    Topics: Adult; Combined Modality Therapy; Female; Fetal Growth Retardation; Follow-Up Studies; Heroin; Heroi

1992
[Drug dependence, smoking and fetal growth retardation].
    Geburtshilfe und Frauenheilkunde, 1992, Volume: 52, Issue:7

    Topics: Acid-Base Equilibrium; Adult; Birth Weight; Drug Synergism; Female; Fetal Growth Retardation; Gestat

1992
[Heroin abuse and methadone substitution in pregnancy].
    Geburtshilfe und Frauenheilkunde, 1992, Volume: 52, Issue:3

    Topics: Asphyxia Neonatorum; Cardiotocography; Dose-Response Relationship, Drug; Female; Fetal Growth Retard

1992
[Drug substitution and withdrawal in pregnancy. Indication, side effects, acute status, monitoring and results].
    Der Gynakologe, 1991, Volume: 24, Issue:6

    Topics: Contraindications; Counseling; Drug Overdose; Female; Heroin Dependence; Humans; Infant, Newborn; Me

1991
[Jurisprudence aspects of drug substitution and withdrawal in pregnancy].
    Der Gynakologe, 1991, Volume: 24, Issue:6

    Topics: Female; Germany; Humans; Infant, Newborn; Jurisprudence; Methadone; Neonatal Abstinence Syndrome; Pr

1991
Prenatal exposure to methadone affects central cholinergic neuronal activity in the weanling rat.
    Brain research. Developmental brain research, 1991, Dec-17, Volume: 64, Issue:1-2

    Topics: Acetylcholine; Animals; Brain; Dopamine; Female; Methadone; Neurons; Norepinephrine; Parasympathetic

1991
The effect of chronic oral methadone treatment on monkey chorionic gonadotropin, estradiol, dehydroepiandrosterone sulfate, progesterone, prolactin and cortisol levels during pregnancy in the cynomolgus monkey (Macaca fascicularis).
    European journal of obstetrics, gynecology, and reproductive biology, 1991, Jan-30, Volume: 38, Issue:2

    Topics: Animals; Birth Weight; Chorionic Gonadotropin; Dehydroepiandrosterone; Estradiol; Female; Fetal Grow

1991
The effect of prenatal methadone exposure of development and nociception during the early postnatal period of the rat.
    NIDA research monograph, 1990, Volume: 105

    Topics: Animals; Female; Methadone; Morphine; Nociceptors; Pregnancy; Prenatal Exposure Delayed Effects; Rat

1990
Methadone levels and neonatal withdrawal.
    Journal of paediatrics and child health, 1991, Volume: 27, Issue:2

    Topics: Adult; Dose-Response Relationship, Drug; Female; Fetal Blood; Humans; Infant, Newborn; Male; Methado

1991
A comparison of the effects of single- and split-dose methadone administration on the fetus: ultrasound evaluation.
    The International journal of the addictions, 1991, Volume: 26, Issue:2

    Topics: Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fetal Movement; Humans; Infa

1991
The effect of prenatal exposure to methadone on neurotransmitters in neonatal rats.
    Brain research. Developmental brain research, 1990, Dec-15, Volume: 57, Issue:2

    Topics: Acetylcholine; Animals; Animals, Newborn; Brain Chemistry; Corpus Striatum; Dopamine; Female; Male;

1990
Narcotic addiction: the expectant mother and her baby.
    Irish medical journal, 1990, Volume: 83, Issue:4

    Topics: Adolescent; Adult; Diseases in Twins; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Pr

1990
[Prenatal development and postnatal morbidity of newborn infants of HIV positive mothers].
    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1990, Volume: 138, Issue:12

    Topics: Birth Weight; Female; Fetal Growth Retardation; Gestational Age; HIV Seropositivity; Humans; Infant,

1990
Report of the Expert Advisory Committee on the Use of Drugs in the Treatment of Abuse and Dependence to Narcotic and Controlled Drugs.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1990, Nov-01, Volume: 143, Issue:9

    Topics: Canada; Drug and Narcotic Control; Female; Humans; Inactivation, Metabolic; Methadone; Opioid-Relate

1990
Diazepam abuse in pregnant women on methadone maintenance. Implications for the neonate.
    Clinical pediatrics, 1990, Volume: 29, Issue:2

    Topics: Adult; Diazepam; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Infant, Newborn, Diseas

1990
Patterns of multiple substance abuse during pregnancy: implications for mother and fetus.
    Southern medical journal, 1990, Volume: 83, Issue:5

    Topics: Adolescent; Adult; Age Factors; Alcoholism; Cocaine; Female; Fetal Diseases; Heroin; Humans; Marijua

1990
Infrequent neonatal opiate withdrawal following maternal methadone detoxification during pregnancy.
    Journal of perinatal medicine, 1990, Volume: 18, Issue:2

    Topics: Adult; Birth Weight; Embryonic and Fetal Development; Female; Humans; Infant, Newborn; Maternal-Feta

1990
Effects of prenatal methadone exposure on sex-dimorphic behavior in early school-age children.
    Psychoneuroendocrinology, 1990, Volume: 15, Issue:1

    Topics: Child; Female; Gender Identity; Humans; Male; Methadone; Pregnancy; Prenatal Exposure Delayed Effect

1990
Drug-addicted mothers, their infants, and SIDS.
    Annals of the New York Academy of Sciences, 1988, Volume: 533

    Topics: Adult; Alcohol Drinking; Cocaine; Developmental Disabilities; Female; Heroin Dependence; Humans; Inf

1988
Neonatal behavior after drug dependent pregnancy.
    Archives of disease in childhood, 1989, Volume: 64, Issue:2

    Topics: Child; Child Behavior; Child, Preschool; Developmental Disabilities; Electroencephalography; Female;

1989
Altered methadone pharmacokinetics in pregnancy: implications for dosing.
    Journal of substance abuse, 1989, Volume: 1, Issue:4

    Topics: Adult; Computer Simulation; Dose-Response Relationship, Drug; Drug Administration Schedule; Female;

1989
Kinin-kininase system in drug addict woman in pregnancy and puerperium.
    Advances in experimental medicine and biology, 1989, Volume: 247B

    Topics: Carboxypeptidases; Female; Humans; Kallikreins; Lysine Carboxypeptidase; Methadone; Peptidyl-Dipepti

1989
Kallikrein-kinin system in newborns of the drug addicted.
    Advances in experimental medicine and biology, 1989, Volume: 247B

    Topics: Aging; Carboxypeptidases; Female; Humans; Infant, Newborn; Kallikreins; Lysine Carboxypeptidase; Mal

1989
Outpatient methadone programme for pregnant heroin using women.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1989, Volume: 29, Issue:3 Pt 1

    Topics: Adult; Ambulatory Care; Evaluation Studies as Topic; Female; Heroin Dependence; Humans; Methadone; N

1989
[Proposal of a detoxication program for drug dependency in pregnancy].
    Minerva ginecologica, 1989, Volume: 41, Issue:12

    Topics: Female; Humans; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Complications

1989
Prenatal cocaine exposure is associated with respiratory pattern abnormalities.
    American journal of diseases of children (1960), 1989, Volume: 143, Issue:5

    Topics: Apnea; Cheyne-Stokes Respiration; Cocaine; Female; Humans; Infant, Newborn; Methadone; Pregnancy; Pr

1989
NIDA's Medication Development Program--1989.
    NIDA research monograph, 1989, Volume: 95

    Topics: Acquired Immunodeficiency Syndrome; Brain; Cocaine; Drug and Narcotic Control; Female; Heroin Depend

1989
Perinatal cocaine intoxication.
    The Medical journal of Australia, 1989, Mar-20, Volume: 150, Issue:6

    Topics: Adult; Cocaine; Female; Follow-Up Studies; Humans; Infant, Newborn; Male; Methadone; Neonatal Abstin

1989
Clinical studies of infants and children exposed prenatally to heroin.
    Annals of the New York Academy of Sciences, 1989, Volume: 562

    Topics: Child Behavior; Child Development; Child, Preschool; Cognition; Female; Heroin Dependence; Humans; I

1989
Developmental consequences of prenatal exposure to methadone.
    Annals of the New York Academy of Sciences, 1989, Volume: 562

    Topics: Child Development; Child, Preschool; Female; Growth; Humans; Infant; Infant, Newborn; Intelligence;

1989
The effects of methadone treatment on the reactivity of the nonstress test.
    Obstetrics and gynecology, 1989, Volume: 74, Issue:2

    Topics: Female; Fetal Movement; Heart Rate, Fetal; Humans; Methadone; Opioid-Related Disorders; Pregnancy; P

1989
Low prevalence of human immunodeficiency virus infection in methadone program attenders and pregnant intravenous drug users in the western metropolitan region of Sydney.
    Australian and New Zealand journal of medicine, 1989, Volume: 19, Issue:4

    Topics: Adult; Australia; Cross-Sectional Studies; Female; HIV Antibodies; HIV Seropositivity; Humans; Male;

1989
Methadone maintenance in pregnancy: consequences to care and outcome.
    Obstetrics and gynecology, 1989, Volume: 73, Issue:1

    Topics: Female; Humans; Methadone; Pregnancy; Pregnancy Complications; Substance-Related Disorders

1989
Prospective study of human immunodeficiency virus infection and pregnancy outcomes in intravenous drug users.
    JAMA, 1989, Mar-03, Volume: 261, Issue:9

    Topics: Adult; Female; HIV Seropositivity; Hospitalization; Humans; Injections, Intravenous; Methadone; New

1989
Behaviour in first year after drug dependent pregnancy.
    Archives of disease in childhood, 1989, Volume: 64, Issue:2

    Topics: Child Behavior; Child Development; Electroencephalography; Female; Humans; Illicit Drugs; Infant; In

1989
Reduced estriol and dehydroepiandrosterone sulphate plasma levels in methadone-addicted pregnant women.
    European journal of obstetrics, gynecology, and reproductive biology, 1986, Volume: 23, Issue:1-2

    Topics: Adult; Circadian Rhythm; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estriol; Female; Ge

1986
The interference of naloxone hydrochloride in the teratogenic activity of opiates.
    Teratology, 1985, Volume: 31, Issue:2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Central Nervous System; D-Ala(2),MePh

1985
Opioid receptors in human placenta may be affected by methadone and propoxyphene treatment.
    Acta pharmacologica et toxicologica, 1985, Volume: 57, Issue:1

    Topics: Cyclazocine; Dextropropoxyphene; Ethylketocyclazocine; Female; Humans; In Vitro Techniques; Methadon

1985
Maternal-fetal transfer of abused substances: pharmacokinetic and pharmacodynamic data.
    NIDA research monograph, 1985, Volume: 60

    Topics: Amphetamine; Animals; Cocaine; Dronabinol; Female; Fetus; Humans; Kinetics; Lysergic Acid Diethylami

1985
Effects of cocaine on pregnancy outcome.
    NIDA research monograph, 1986, Volume: 67

    Topics: Abortion, Spontaneous; Adult; Birth Weight; Body Height; Female; Humans; Infant, Newborn; Maternal-F

1986
Perinatal and developmental outcome of infants exposed to methadone in-utero.
    NIDA research monograph, 1987, Volume: 76

    Topics: Birth Weight; Female; Humans; Infant, Newborn; Methadone; Pregnancy

1987
Cocaine- and methadone-exposed infants: a comparison.
    NIDA research monograph, 1987, Volume: 76

    Topics: Cocaine; Embryonic and Fetal Development; Female; Humans; Infant, Newborn; Methadone; Obstetric Labo

1987
Inhaling heroin during pregnancy.
    British medical journal (Clinical research ed.), 1988, May-14, Volume: 296, Issue:6633

    Topics: Female; Heroin Dependence; Humans; Methadone; Pregnancy; Pregnancy Complications

1988
Inhaling heroin during pregnancy.
    British medical journal (Clinical research ed.), 1988, Jun-11, Volume: 296, Issue:6637

    Topics: Female; Heroin; Heroin Dependence; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome;

1988
The use of tricyclic antidepressants in methadone maintained pregnant women and infant outcome.
    NIDA research monograph, 1988, Volume: 81

    Topics: Adult; Antidepressive Agents, Tricyclic; Apgar Score; Birth Weight; Demography; Female; Heroin Depen

1988
Methadone maintenance has a tragic price.
    The American journal of nursing, 1988, Volume: 88, Issue:12

    Topics: Adolescent; Child; Child Behavior Disorders; Female; Humans; Infant, Newborn; Methadone; Neonatal Ab

1988
Effects of exposure in utero to methadone and buprenorphine on enkephalin levels in the developing rat brain.
    Neuroscience letters, 1988, Oct-31, Volume: 93, Issue:1

    Topics: Animals; Brain; Buprenorphine; Dose-Response Relationship, Drug; Enkephalins; Female; Methadone; Pre

1988
[Effects of maternal methadone addiction on the growth and health of the fetus].
    Minerva ginecologica, 1988, Volume: 40, Issue:10

    Topics: Embryonic and Fetal Development; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Methadone

1988
A review of the characteristics and treatment progress of 45 pregnant opiate addicts attending the Irish National Drug Advisory and Treatment Centre over a two year period.
    Irish journal of medical science, 1988, Volume: 157, Issue:5

    Topics: Adolescent; Adult; Female; Humans; Infant, Newborn; Ireland; Methadone; Narcotics; Pregnancy; Pregna

1988
Group psychotherapy with methadone-maintained pregnant women.
    Journal of substance abuse treatment, 1988, Volume: 5, Issue:3

    Topics: Adult; Attitude of Health Personnel; Female; Humans; Methadone; Opioid-Related Disorders; Patient Ed

1988
The effect of chronic methadone treatment on intra-uterine growth of the cynomolgus monkey (Macaca fascicularis).
    European journal of obstetrics, gynecology, and reproductive biology, 1988, Volume: 27, Issue:1

    Topics: Animals; Birth Weight; Embryonic and Fetal Development; Female; Macaca fascicularis; Methadone; Preg

1988
Methadone maintenance in pregnancy: consequences to care and outcome.
    Obstetrics and gynecology, 1988, Volume: 71, Issue:3 Pt 1

    Topics: Adult; Alcohol Drinking; Drug Evaluation, Preclinical; Female; Hematocrit; Humans; Methadone; Pregna

1988
Maternal narcotic abuse and the newborn.
    Archives of disease in childhood, 1988, Volume: 63, Issue:1

    Topics: Adolescent; Adult; Female; Heroin; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinenc

1988
An extended physiological pharmacokinetic model of methadone disposition in the rat: validation and sensitivity analysis.
    Journal of pharmacokinetics and biopharmaceutics, 1988, Volume: 16, Issue:2

    Topics: Animals; Female; Methadone; Models, Biological; Pregnancy; Rats

1988
Maternal drug therapy: effect on fetal and neonatal growth and neurobehavior.
    Neurotoxicology, 1986,Summer, Volume: 7, Issue:2

    Topics: Aminopterin; Amphetamines; Animals; Anticoagulants; Anticonvulsants; Antihypertensive Agents; Birth

1986
Pregnancy in a drug-abusing population.
    The American journal of drug and alcohol abuse, 1986, Volume: 12, Issue:3

    Topics: Adult; Female; Gestational Age; Humans; Infant, Newborn; Methadone; Pregnancy; Pregnancy Complicatio

1986
Heroin addiction in pregnancy.
    Midwives chronicle, 1986, Volume: 99, Issue:1182

    Topics: Female; Heroin Dependence; Humans; Methadone; Midwifery; Pregnancy; Pregnancy Complications

1986
Management of narcotic dependent pregnancy.
    The Australian nurses' journal. Royal Australian Nursing Federation, 1986, Volume: 16, Issue:2

    Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Narcotics; Opioid-Related Disorders;

1986
Perinatal cocaine and methamphetamine exposure: maternal and neonatal correlates.
    The Journal of pediatrics, 1987, Volume: 111, Issue:4

    Topics: Apgar Score; Birth Weight; Child Behavior; Cocaine; Female; Fetal Growth Retardation; Gestational Ag

1987
Impact of maternal drug dependency on birth weight and head circumference of offspring.
    American journal of diseases of children (1960), 1987, Volume: 141, Issue:11

    Topics: Adult; Birth Weight; Female; Fetal Growth Retardation; Fetus; Head; Humans; Infant, Newborn; Methado

1987
Maternal narcotic addiction: pregnancy outcome in patients managed by a specialized drug-dependency antenatal clinic.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1987, Volume: 27, Issue:2

    Topics: Adolescent; Adult; Female; Fetal Death; Health Facilities; Heroin Dependence; Humans; Infant, Newbor

1987
Effect of maternal methadone administration on the development of multiple forms of monoamine oxidase in rat brain and liver.
    Brain research, 1986, Volume: 391, Issue:2

    Topics: Animals; Brain; Female; Isoenzymes; Liver; Methadone; Monoamine Oxidase; Opioid-Related Disorders; P

1986
Methadone in pregnancy: clinical-toxicological aspects.
    Journal of toxicology. Clinical toxicology, 1986, Volume: 24, Issue:4

    Topics: Female; Humans; Infant, Newborn; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Complicat

1986
Abnormal sleeping ventilatory pattern in infants of substance-abusing mothers.
    American journal of diseases of children (1960), 1986, Volume: 140, Issue:10

    Topics: Age Factors; Cocaine; Female; Heart Rate; Heroin; Humans; Infant; Male; Methadone; Narcotics; Phency

1986
Mother-infant interaction in multiproblem families: finding those at risk.
    Journal of the American Academy of Child Psychiatry, 1986, Volume: 25, Issue:5

    Topics: Adult; Child Development; Female; Humans; Infant; Methadone; Mother-Child Relations; Opioid-Related

1986
Fetal addiction to methadone: postnatal abstinence syndrome and development of visual evoked potentials.
    Drug and alcohol dependence, 1986, Volume: 18, Issue:1

    Topics: Animals; Electroencephalography; Evoked Potentials, Visual; Female; Maternal-Fetal Exchange; Methado

1986
A comparative study of the reproductive effects of methadone and benzo[a]pyrene in the pregnant and pseudopregnant rat.
    Toxicology, 1986, Dec-15, Volume: 42, Issue:2-3

    Topics: Animals; Benzo(a)pyrene; Female; Fetal Death; Fetal Resorption; Litter Size; Methadone; Nucleotides,

1986
[Substance dependence and pregnancy. Experience in care].
    Minerva ginecologica, 1986, Volume: 38, Issue:11

    Topics: Adult; Female; Fetal Growth Retardation; Heroin; Heroin Dependence; Humans; Methadone; Pregnancy; Pr

1986
Occurrence of strabismus in infants born to drug-dependent women.
    American journal of diseases of children (1960), 1987, Volume: 141, Issue:2

    Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Male; Methadone; Pregnancy; Pregnancy Complicati

1987
Prenatal opioid exposure and the problem of causal inference.
    NIDA research monograph, 1985, Volume: 59

    Topics: Animals; Child Development; Dose-Response Relationship, Drug; Female; Fetus; Humans; Kinetics; Metha

1985
Long-term effects of prenatal methadone maintenance.
    NIDA research monograph, 1985, Volume: 59

    Topics: Adult; Age Factors; Child; Child Behavior; Child Development; Child, Preschool; Female; Fetus; Follo

1985
Factors affecting head growth and intellectual function in children of drug addicts.
    Pediatrics, 1985, Volume: 75, Issue:2

    Topics: Age Factors; Cephalometry; Child Development; Cognition; Female; Follow-Up Studies; Head; Heroin Dep

1985
Altered methadone pharmacokinetics in methadone-maintained pregnant women.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 233, Issue:1

    Topics: Adult; Female; Humans; Metabolic Clearance Rate; Methadone; Milk, Human; Pregnancy; Pregnancy Compli

1985
Perinatal exposure to methadone and the development of hepatic microsomal testosterone hydroxylation and methadone N-demethylation in the rat.
    Biochemical pharmacology, 1985, May-01, Volume: 34, Issue:9

    Topics: Animals; Animals, Newborn; Dealkylation; Female; Fetus; Hydroxylation; Male; Methadone; Microsomes,

1985
Cocaine use in pregnancy.
    The New England journal of medicine, 1985, Sep-12, Volume: 313, Issue:11

    Topics: Abortion, Spontaneous; Adult; Cocaine; Female; Fetus; Humans; Infant, Newborn; Methadone; Obstetric

1985
Opiate self-administration in adult offspring of methadone-treated female rats.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:6

    Topics: Animals; Body Weight; Drinking; Female; Methadone; Morphine; Narcotics; Pregnancy; Prenatal Exposure

1985
Methadone-maintained mothers: 3-year follow-up of parental functioning.
    The International journal of the addictions, 1985, Volume: 20, Issue:5

    Topics: Child Development; Child Rearing; Female; Follow-Up Studies; Heroin Dependence; Humans; Infant; Infa

1985
When the client is pregnant: information for counselors.
    Journal of substance abuse treatment, 1985, Volume: 2, Issue:1

    Topics: Adult; Attitude of Health Personnel; Breast Feeding; Family Planning Services; Female; Guilt; Heroin

1985
[Withdrawal symptoms and behavioral disorders in children of mothers taking heroin/methadone during pregnancy].
    Lakartidningen, 1985, Aug-07, Volume: 82, Issue:32-33

    Topics: Adult; Child Behavior Disorders; Child Development; Child, Preschool; Female; Follow-Up Studies; Her

1985
Offspring born to methadone-maintained women.
    The American journal of drug and alcohol abuse, 1985, Volume: 11, Issue:1-2

    Topics: Female; Humans; Infant; Infant, Newborn; Longitudinal Studies; Maternal-Fetal Exchange; Methadone; P

1985
Urinary function during epidural analgesia with methadone and morphine in post-cesarean section patients.
    Pain, 1985, Volume: 23, Issue:2

    Topics: Adult; Anesthesia, Epidural; Cesarean Section; Female; Humans; Methadone; Morphine; Pain, Postoperat

1985
Analysis of methadone disposition in the pregnant rat by means of a physiological flow model.
    Journal of pharmacokinetics and biopharmaceutics, 1985, Volume: 13, Issue:4

    Topics: Animals; Female; Gas Chromatography-Mass Spectrometry; Infusions, Parenteral; Injections, Intravenou

1985
Rapid phospholipid test for fetal pulmonary maturity.
    Gynecologic investigation, 1974, Volume: 5, Issue:5-6

    Topics: Amniotic Fluid; Chromatography, Paper; Densitometry; Female; Humans; Infant, Newborn; Methadone; Pho

1974
The effect of acute and chronic methadone treatment on the in vitro N-demethylation of methadone by microsomal enzymes of male and pregnant and nonpregnant female rats.
    Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 205, Issue:2

    Topics: Animals; Dealkylation; Female; Fetus; Glucosephosphates; In Vitro Techniques; Kinetics; Magnesium; M

1973
[Discussion on methadone programs in the Federal Republic of Germany].
    Deutsche medizinische Wochenschrift (1946), 1973, Volume: 98, Issue:43

    Topics: Ambulatory Care; Female; Germany, West; Heroin Dependence; Hospitalization; Humans; Long-Term Care;

1973
Letter: Pentazocine and neonatal withdrawal symptoms.
    The Journal of pediatrics, 1974, Volume: 85, Issue:5

    Topics: Female; Glutethimide; Humans; Infant, Newborn; Infant, Newborn, Diseases; Long-Term Care; Maternal-F

1974
Estriol excretion profiles in narcotic-addicted pregnant women.
    American journal of obstetrics and gynecology, 1972, Volume: 112, Issue:5

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Age Fact

1972
Infant of the addicted mother.
    The New England journal of medicine, 1973, Jun-28, Volume: 288, Issue:26

    Topics: Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Disea

1973
The effect of a methadone treatment program upon pregnant heroin addicts and their newborn infants.
    Pediatrics, 1974, Volume: 54, Issue:3

    Topics: Adult; Birth Weight; Blood Glucose; Calcium; Female; Fetus; Gestational Age; Heroin Dependence; Huma

1974
Methadone maintenance during pregnancy: pregnancy, birth, and neonate characteristics.
    American journal of obstetrics and gynecology, 1974, Dec-01, Volume: 120, Issue:7

    Topics: Adolescent; Adult; Apgar Score; Birth Weight; Female; Gestational Age; Heroin Dependence; Humans; In

1974
Postpartum weight alteration in hamster offspring from females injected during pregnancy with either heroin, methadone, a composite drug mixture, or mescaline.
    American journal of obstetrics and gynecology, 1974, Dec-15, Volume: 120, Issue:8

    Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Cricetinae; Drug Combinations; Female; Her

1974
Methadone: the mechanism of its success.
    The Journal of nervous and mental disease, 1974, Volume: 159, Issue:5

    Topics: Disease Outbreaks; Drug and Narcotic Control; Female; Heroin Dependence; Humans; Methadone; Pregnanc

1974
[Previous opiate addictions: trial of substitutive therapy using methadone chlorhydrate].
    Annales de medecine interne, 1974, Volume: 125, Issue:5

    Topics: Administration, Oral; Adult; Ambulatory Care; Codeine; Female; Heroin Dependence; Hospitalization; H

1974
Methadone treatment of heroin dependence.
    Rocky Mountain medical journal, 1974, Volume: 71, Issue:9

    Topics: Female; Heroin Dependence; Humans; Methadone; Pregnancy

1974
Clinical uses of the Brazelton Neonatal Scale.
    Pediatrics, 1974, Volume: 54, Issue:5

    Topics: Child Behavior; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Metha

1974
Treatment of heroin addiction. Multimodality approach.
    New York state journal of medicine, 1973, May-01, Volume: 73, Issue:9

    Topics: Counseling; Cyclazocine; Day Care, Medical; Female; Heroin; Heroin Dependence; Humans; Male; Methado

1973
Pregnancies of methadone patients. Findings in New York City Methadone Maintenance Treatment Program.
    New York state journal of medicine, 1974, Volume: 74, Issue:1

    Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases;

1974
Teratogenic activity of methadone hydrochloride in mouse and chick embryos.
    Journal of embryology and experimental morphology, 1973, Volume: 30, Issue:2

    Topics: Abnormalities, Drug-Induced; Anencephaly; Animals; Brain; Chick Embryo; Embryo, Mammalian; Female; G

1973
Analyses of methadone and other drugs in maternal and neonatal body fluids: use in evaluation of symptoms in a neonate of mother maintained on methadone.
    The American journal of drug and alcohol abuse, 1974, Volume: 1, Issue:3

    Topics: Adult; Amniotic Fluid; Body Fluids; Escherichia coli Infections; Female; Fetal Blood; Heroin Depende

1974
Evaluation of a latex tube agglutination-inhibition pregnancy test. An analysis of 1,776 specimens.
    American journal of obstetrics and gynecology, 1973, Jul-01, Volume: 116, Issue:5

    Topics: Adult; Agglutination Tests; Antibodies; Chorionic Gonadotropin; Chromatography, Thin Layer; Evaluati

1973
Effect of methadone on human pregnancy tests.
    Journal of reproduction and fertility, 1973, Volume: 33, Issue:3

    Topics: Chromatography, Thin Layer; False Positive Reactions; Female; Humans; Male; Methadone; Pregnancy; Pr

1973
Guidelines for the withdrawal of narcotic and general depressant drugs.
    Diseases of the nervous system, 1973, Volume: 34, Issue:3

    Topics: Barbiturates; Dose-Response Relationship, Drug; Drug Tolerance; Female; Heroin; Humans; Hypnotics an

1973
Effect of heroin on corticosteroid production in pregnant addicts and their fetuses.
    American journal of obstetrics and gynecology, 1973, Oct-01, Volume: 117, Issue:3

    Topics: Adrenal Cortex Hormones; Birth Weight; Blood; Delivery, Obstetric; Female; Fetus; Gestational Age; H

1973
The quantitation of methadone in human amniotic fluid.
    Research communications in chemical pathology and pharmacology, 1973, Volume: 6, Issue:1

    Topics: Adult; Amniocentesis; Amniotic Fluid; Chromatography, Gas; Female; Humans; Maternal-Fetal Exchange;

1973
Methadone maintenance, pregnancy, and progeny.
    JAMA, 1973, Jul-30, Volume: 225, Issue:5

    Topics: Administration, Oral; Adult; Apgar Score; Birth Weight; Female; Fetal Death; Heroin; Heroin Dependen

1973
[Psychiatric emergencies during pregnancy and in the puerperium].
    Munchener medizinische Wochenschrift (1950), 1973, Jun-01, Volume: 115, Issue:22

    Topics: Amphetamine; Cannabis; Emergencies; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lyse

1973
Neonatal narcotic addiction. Comparative effects of maternal intake of heroin and methadone.
    The New England journal of medicine, 1973, Dec-06, Volume: 289, Issue:23

    Topics: Adult; Apgar Score; Birth Weight; Chlorpromazine; Female; Gestational Age; Heroin Dependence; Humans

1973
Massachusetts Department of Public Health. Massachusetts methadone maintenance programs.
    The New England journal of medicine, 1973, Dec-27, Volume: 289, Issue:26

    Topics: Adolescent; Boston; Drug and Narcotic Control; Female; Heroin Dependence; Humans; Massachusetts; Met

1973
A model for drug abuse treatment program evaluation.
    Preventive medicine, 1973, Volume: 2, Issue:4

    Topics: Adult; Black or African American; Community Health Services; Counseling; Educational Status; Evaluat

1973
Methadone maintenance during pregnancy.
    American journal of diseases of children (1960), 1973, Volume: 126, Issue:4

    Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Pregnancy;

1973
The New York City Methadone Maintenance Treatment Program after two years - an overview.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 1

    Topics: Adolescent; Community Health Services; Crime; Female; Hepatitis B; Heroin Dependence; Humans; Methad

1973
Special treatment problems in a drug abuse program.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2

    Topics: Adolescent; Alcoholism; Animals; Escape Reaction; Female; Heroin Dependence; Humans; Illinois; Inter

1973
Results of 120 deliveries of patients in the New York City methadone maintenance treatment program.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2

    Topics: Adolescent; Adult; Birth Weight; Delivery, Obstetric; Demography; Ethnicity; Female; Heroin Dependen

1973
Observations on the sudden death of infants born to addicted mothers.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2

    Topics: Adult; Death, Sudden; Female; Heroin Dependence; Humans; Infant; Infant Mortality; Infant, Newborn;

1973
The effect of a methadone treatment program upon pregnant addicts and their infants.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2

    Topics: Adult; Apgar Score; Female; Hepatitis; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn;

1973
Clinical evaluation of pregnant methadone maintenance patients and their newborn infants.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2

    Topics: Adolescent; Adult; Community Health Services; Evaluation Studies as Topic; Female; Heroin Dependence

1973
Treatment experiences with the pregnant addict.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2

    Topics: Adolescent; Adult; Amniotic Fluid; Female; Gestational Age; Hepatitis; Heroin Dependence; Humans; In

1973
Neonatal effects of heroin addiction and methadone-treated pregnancies. Preliminary report on 70 live births.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2

    Topics: Adult; Birth Weight; Dose-Response Relationship, Drug; Female; Heroin Dependence; Humans; Infant, Ne

1973
Pregnancy in the context of narcotic addiction and methadone maintenance.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2

    Topics: Adult; Alcoholism; Barbiturates; Chicago; Female; Heroin Dependence; Humans; Infant Mortality; Infan

1973
L0w dose methadone to abstinence in a maternity-family care program.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2

    Topics: Adult; Family Therapy; Female; Heroin Dependence; Humans; Male; Methadone; Pregnancy; Pregnancy Comp

1973
A preliminary (8-month) report on a low-dose methadone-to-abstinence family care program at Kings County Addicitve Disease Hospital.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2

    Topics: Adolescent; Adult; Community Health Services; Counseling; Female; Heroin Dependence; Humans; Male; M

1973
Methadone effects on pregnancy and the newborn.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2

    Topics: Adolescent; Adult; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Ma

1973
Late presentation of drug withdrawal symptoms in newborns.
    American journal of diseases of children (1960), 1974, Volume: 127, Issue:1

    Topics: Birth Weight; Camphor; Diazepam; Female; Gestational Age; Heroin Dependence; Humans; Infant; Infant,

1974
Content of amniotic fluid prostaglandins in normal, diabetic, and drug-abuse human pregnancy.
    American journal of obstetrics and gynecology, 1974, Feb-01, Volume: 118, Issue:3

    Topics: Amniotic Fluid; Female; Heroin Dependence; Humans; Labor, Obstetric; Methadone; Pregnancy; Pregnancy

1974
Narcotic withdrawal in the newborn infant.
    Journal of the National Medical Association, 1974, Volume: 66, Issue:2

    Topics: Diazepam; Female; Fetus; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Mate

1974
Evaluation of a latex agglutination-inhibition slide pregnancy test (Pregnosis).
    Obstetrics and gynecology, 1974, Volume: 43, Issue:5

    Topics: Abortion, Spontaneous; Adolescent; Adult; Antidepressive Agents; Chorionic Gonadotropin; Codeine; Co

1974
Effect of chronic methadone adminstration on pregnant rats and their offspring.
    The Journal of pharmacology and experimental therapeutics, 1974, Volume: 189, Issue:1

    Topics: Animals; Animals, Newborn; Body Weight; Embryonic and Fetal Development; Female; Fertility; Fetal De

1974
Born with a habit. Infants of drug-addicted mothers.
    Pediatric clinics of North America, 1974, Volume: 21, Issue:2

    Topics: Abnormalities, Drug-Induced; Adult; Age Factors; Barbiturates; Camphor; Chlorpromazine; Codeine; Dia

1974
Perinatal tips.
    Michigan medicine, 1974, Volume: 73, Issue:9

    Topics: Chlorpromazine; Education, Medical, Continuing; Female; Humans; Infant, Newborn; Infant, Newborn, Di

1974
Letter: Evaluation of five commercial pregnancy test kits using urine samples containing methadone.
    Canadian Medical Association journal, 1974, Aug-03, Volume: 111, Issue:3

    Topics: Chromatography, Thin Layer; False Positive Reactions; Female; Humans; Male; Methadone; Pregnancy; Pr

1974
Studies of human amniotic fluid phospholipids in normal, diabetic, and drug-abuse pregnancy.
    American journal of obstetrics and gynecology, 1974, Jul-01, Volume: 119, Issue:5

    Topics: Amniotic Fluid; Chromatography, Gas; Chromatography, Thin Layer; Densitometry; Fatty Acids; Female;

1974
Teratogenicity studies of methadone HCl in rats and rabbits.
    Nature, 1971, Oct-01, Volume: 233, Issue:5318

    Topics: Abnormalities, Drug-Induced; Animals; Female; Hydrocephalus; Maternal-Fetal Exchange; Methadone; Pre

1971
Heroin addiction during pregnancy.
    American journal of obstetrics and gynecology, 1972, May-15, Volume: 113, Issue:2

    Topics: Adolescent; Adult; Amniocentesis; Bilirubin; Birth Weight; Female; Gestational Age; Heroin; Humans;

1972
The distribution of methadone in the nonpregnant, pregnant and fetal rat after acute methadone treatment.
    The Journal of pharmacology and experimental therapeutics, 1972, Volume: 181, Issue:2

    Topics: Animals; Brain Chemistry; Carbon Isotopes; Female; Fetus; Gestational Age; Injections, Intraperitone

1972
"Cold turkey" in the newborn.
    The Medical journal of Australia, 1972, Feb-19, Volume: 1, Issue:8

    Topics: Adult; Australia; Diagnosis, Differential; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange;

1972
Methadone withdrawal in newborn infants.
    The Journal of pediatrics, 1972, Volume: 81, Issue:3

    Topics: Female; Gestational Age; Heroin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Maternal-

1972
Treatment of a pregnant opiate addict with oral methadone.
    Arizona medicine, 1972, Volume: 29, Issue:2

    Topics: Administration, Oral; Adult; Female; Heroin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Met

1972
Treatment of morphine-type dependence by withdrawal methods.
    JAMA, 1972, Mar-20, Volume: 219, Issue:12

    Topics: Barbiturates; Female; Heroin; Hospitalization; Humans; Male; Meperidine; Methadone; Morphine; Pregna

1972
Oral methadone maintenance techniques in the management of morphine-type dependence.
    JAMA, 1972, Mar-20, Volume: 219, Issue:12

    Topics: Female; Heroin; Hospitalization; Humans; Male; Methadone; Morphine; Pregnancy; Substance-Related Dis

1972
Sudden deaths in infants born to methadone-maintained addicts.
    JAMA, 1972, Jun-26, Volume: 220, Issue:13

    Topics: Adult; Apgar Score; Birth Weight; Death, Sudden; Female; Humans; Infant; Infant Mortality; Maternal-

1972
Treatment of morphine-type dependence.
    JAMA, 1972, Sep-25, Volume: 221, Issue:13

    Topics: Female; Gestational Age; Heroin; Humans; Male; Methadone; Morphine Dependence; Pregnancy; Substance

1972
Drug addiction in pregnancy. An obstetrician's experience.
    Proceedings of the Royal Society of Medicine, 1972, Volume: 65, Issue:10

    Topics: Abortion, Induced; Abortion, Spontaneous; Amenorrhea; Anesthesia, Obstetrical; Female; Humans; Infan

1972
Narcotic withdrawal in the newborn.
    American family physician, 1972, Volume: 6, Issue:1

    Topics: Birth Weight; Chlorpromazine; Cocaine; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, N

1972
Neonatal addiction to methadone.
    Pediatrics, 1971, Volume: 47, Issue:4

    Topics: Female; Heroin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Methado

1971
Effects of methadone on the action of catecholamines in isolated preparations.
    Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 192, Issue:1

    Topics: Acetylcholine; Animals; Barium; Cats; Cocaine; Drug Antagonism; Drug Synergism; Epinephrine; Female;

1971
Observations on heroin and methadone withdrawal in the newborn.
    Pediatrics, 1971, Volume: 48, Issue:3

    Topics: Adolescent; Adult; Apgar Score; Birth Weight; Female; Heroin; Humans; Infant, Newborn; Infant, Newbo

1971
Fertility of narcotics addicts and effects of addiction on the offspring.
    Social biology, 1971, Volume: 18

    Topics: Female; Fertility; Heroin; Humans; Infant, Newborn; Maternal-Fetal Exchange; Methadone; Morphine Dep

1971
Neonatal biliary tract infection coincident with maternal methadone therapy.
    Pediatrics, 1971, Volume: 48, Issue:6

    Topics: Adult; Cholangitis; Cholecystitis; Female; Heroin; Humans; Infant, Newborn; Infant, Newborn, Disease

1971
Narcotics and medical practice. Medical use of morphine and morphine-like drugs and management of persons dependent on them.
    JAMA, 1971, Oct-25, Volume: 218, Issue:4

    Topics: American Medical Association; Female; Health Education; Heroin; Humans; Legislation, Drug; Methadone

1971
Pregnancy in narcotics addicts treated by medical withdrawal. The methadone detoxification program.
    American journal of obstetrics and gynecology, 1969, Dec-01, Volume: 105, Issue:7

    Topics: Adolescent; Adult; Birth Weight; Female; Heroin; Humans; Infant, Newborn; Labor Presentation; Methad

1969
Pregnancy and menstrual function in narcotics addicts treated with methadone. The Methadone Maintenance Treatment Program.
    American journal of obstetrics and gynecology, 1969, Dec-15, Volume: 105, Issue:8

    Topics: Adult; Female; Heroin; Humans; Infertility, Female; Menstruation; Methadone; Ovulation; Pregnancy; S

1969
Methadone and children.
    Pediatrics, 1971, Volume: 48, Issue:2

    Topics: Adolescent; Adult; Child, Preschool; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Mat

1971
Menstrual function and pregnancy in narcotics addicts treated with methadone.
    Nature, 1968, Jul-13, Volume: 219, Issue:5150

    Topics: Abortion, Spontaneous; Adult; Amenorrhea; Female; Fetal Death; Humans; Infant, Newborn; Menstruation

1968