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methadone and Pain

methadone has been researched along with Pain in 480 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Pain in opioid-dependent patients is common but data measuring the course of pain (and its correlates) using validated scales in patients initiating methadone treatment are sparse."9.24Pain in methadone patients: Time to address undertreatment and suicide risk (ANRS-Methaville trial). ( Bendiane, MK; Carrieri, P; Lions, C; Maradan, G; Michel, L; Mora, M; Morel, A; Nordmann, S; Roux, P; Spire, B; Vilotitch, A, 2017)
"This analysis explored the prevalence and correlates of pain in patients enrolled in methadone maintenance treatment (MMT)."9.17Epidemiology of pain among outpatients in methadone maintenance treatment programs. ( Dhingra, L; Homel, P; Jordan, AE; Katz, J; Masson, C; McKnight, C; Perlman, DC; Portenoy, RK; Seewald, RM; Wald, E; Young, C, 2013)
"This study was designed to evaluate the role of epidural methadone-lidocaine in cancer pain combined or not to epidural dexamethasone."9.17Epidural methadone results in dose-dependent analgesia in cancer pain, further enhanced by epidural dexamethasone. ( Lauretti, GR; Mattos, AL; Rizzo, CC; Rodrigues, SW, 2013)
"The objective of the study was to describe the experience of methadone use in 100 consecutive chronic pain patients managed in a single multidisciplinary center."9.13Experience of methadone therapy in 100 consecutive chronic pain patients in a multidisciplinary pain center. ( Evans, D; Galonski, M; Gordon, A; Gourlay, D; Peng, P; Stafford, M; Tumber, P; Wong, P, 2008)
"To compare the effectiveness and side effects of methadone and morphine as first-line treatment with opioids for cancer pain."9.11Methadone versus morphine as a first-line strong opioid for cancer pain: a randomized, double-blind study. ( Bertolino, M; Bosnjak, S; Bruera, E; Fisch, MJ; Mathias, C; Moyano, J; Palmer, JL; Rico, MA; Spruyt, O; Strasser, F; Sweeney, C; Willey, J, 2004)
"Methadone is effective for chronic cancer pain, but its early pharmacodynamic profile and effectiveness for breakthrough pain remain uncertain."9.11Characterization of the early pharmacodynamic profile of oral methadone for cancer-related breakthrough pain: a pilot study. ( Fisher, K; Hagen, NA; Stiles, C, 2004)
"The aim of this study is to characterize patients with chronic pain in methadone maintenance treatment (MMT)."9.11Significantly higher methadone dose for methadone maintenance treatment (MMT) patients with chronic pain. ( Adelson, M; Gordon, J; Peles, E; Schreiber, S, 2005)
"Methadone is a strong opioid analgesic that has been used successfully in cancer pain management."9.11Intermittent subcutaneous methadone administration in the management of cancer pain. ( Centeno, C; Vara, F, 2005)
"This prospective study documents the use of methadone as part of an opioid rotation strategy in patients with uncontrolled pain and severe delirium admitted for terminal care to a tertiary cancer palliative care hospital."9.11Methadone in the treatment of pain and terminal delirum in advanced cancer patients. ( Comfort, C; Kogan, M; Moryl, N; Obbens, E, 2005)
"The successful use of methadone in cancer pain has been supported by numerous case reports and clinical studies."9.10Pitfalls of opioid rotation: substituting another opioid for methadone in patients with cancer pain. ( Derby, S; Fischberg, D; Kornick, C; Manfredi, PL; Moryl, N; Payne, R; Santiago-Palma, J, 2002)
"To assess the use of methadone in patients with cancer pain who fail to respond to increasing doses of other opioids or experience intolerable side-effects from them."9.09Methadone titration in opioid-resistant cancer pain. ( Gonty, N; Scholes, CF; Trotman, IF, 1999)
"The use of methadone in the treatment of cancer pain is becoming more attractive mainly because of its known efficacy, lack of active metabolites, and low cost."9.09Differences in the ratios of morphine to methadone in patients with neuropathic pain versus non-neuropathic pain. ( Bruera, E; Gagnon, B, 1999)
"In a prospective, open study, 37 advanced cancer patients in poor pain control receiving high doses of subcutaneous hydromorphone (mean daily dose: 276 +/- 163 mg) were switched to methadone by use of custom-made capsules (21 patients) or suppositories (16 patients)."9.08Custom-made capsules and suppositories of methadone for patients on high-dose opioids for cancer pain. ( Bruera, E; Fainsinger, RL; Inturrisi, C; Spachynski, K; Suarez-Almazor, M; Watanabe, S, 1995)
"Methadone is a very useful drug in cancer pain because of its low cost, lack of active metabolites, high oral availability, and the rapid onset of its analgesic effect."9.08Patient-controlled analgesia with oral methadone in cancer pain: preliminary report. ( Caligara, M; Mercadante, S; Sapio, M; Serretta, R, 1996)
"To determine the relationship between changes in plasma methadone concentration and pharmacodynamic effects, plasma methadone profiles and pharmacodynamics (analgesia and sedation) were measured during and after the continuous infusion of methadone for 180 to 270 minutes in 15 patients with pain caused by cancer."9.06Pharmacokinetic-pharmacodynamic relationships of methadone infusions in patients with cancer pain. ( Colburn, WA; Foley, KM; Inturrisi, CE; Max, MB; Portenoy, RK, 1990)
"Eighteen patients suffering from cancer were entered into a study of the pharmacokinetics and efficacy of methadone and morphine in pain control."9.06A comparative study of the efficacy and pharmacokinetics of oral methadone and morphine in the treatment of severe pain in patients with cancer. ( Cherry, DA; Cousins, MJ; Gourlay, GK, 1986)
"This study reports the results of a double-blind, parallel-group comparison of intravenous methadone with morphine for the control of postoperative pain."9.06A double-blind comparison of the efficacy of methadone and morphine in postoperative pain control. ( Gourlay, GK; Lamberty, J; Willis, RJ, 1986)
"Methadone, due to its multimechanistic action profile, is possibly among the most effective and most underutilized opioid analgesics in children with severe unrelieved pain at end of life."9.01From Tramadol to Methadone: Opioids in the Treatment of Pain and Dyspnea in Pediatric Palliative Care. ( Friedrichsdorf, SJ, 2019)
"Methadone is a valuable opioid in the management of patients who have cancer with pain."8.98Methadone: Maximizing Safety and Efficacy for Pain Control in Patients with Cancer. ( Costantino, RC; McPherson, AL; McPherson, ML, 2018)
"To determine the effectiveness and tolerability of methadone as an analgesic in adults and children with cancer pain."8.95Methadone for cancer pain. ( Derry, S; Nicholson, AB; Watson, GR; Wiffen, PJ, 2017)
"The proven therapeutic efficacy of methadone in cancer pain is hindered by a challenging pharmacokinetic-pharmacodynamic profile, considerable interpatient variation, and increasing concern about the complexities of dosing."8.90Therapeutic challenges in cancer pain management: a systematic review of methadone. ( Afsharimani, B; Good, P; Hardy, J; Haywood, A; Khan, S; Movva, R, 2014)
"To determine the analgesic efficacy of transdermal fentanyl for relief of cancer pain, and to assess the adverse events associated with the use of transdermal fentanyl for relief of cancer pain."8.89Transdermal fentanyl for cancer pain. ( Derry, S; Hadley, G; Moore, RA; Wiffen, PJ, 2013)
"Methadone is highly effective in treating opioid dependence, and it is also used as an analgesic for second-line management of chronic pain."8.86Methadone deaths: risk factors in pain and addicted populations. ( Brooks, D; Modesto-Lowe, V; Petry, N, 2010)
"Methadone is increasingly prescribed for chronic pain, yet the associated mortality appears to be rising disproportionately relative to other opioid analgesics."8.85Methadone-induced mortality in the treatment of chronic pain: role of QT prolongation. ( Andrews, CM; Capacchione, JF; Haigney, MC; Krantz, MJ; Marcuson, MJ; Wedam, EF, 2009)
"To outline pharmacodynamics, pharmacokinetics, drug interactions, equianalgesic dose ratio with other opioids, dosing rules, adverse effects and methadone clinical studies in patients with cancer pain."8.85The role of methadone in cancer pain treatment--a review. ( Leppert, W, 2009)
"Methadone is an opioid used in the management of cancer pain."8.84Methadone for cancer pain. ( Nicholson, AB, 2007)
"This topical review addresses methadone's pharmacology, its application in malignant and non-malignant pain conditions, practical issues related to methadone for the treatment of pain and its influence on QTc time."8.84Clinical pharmacology of methadone for pain. ( Borchgrevink, PC; Dale, O; Fredheim, OM; Kaasa, S; Moksnes, K, 2008)
"Once used only as third-line therapy for chronic pain management, methadone is now being used as first- and second-line therapy in palliative care."8.84Consensus guideline on parenteral methadone use in pain and palliative care. ( Berger, A; Blinderman, CD; Bruera, E; Davis, MP; Derby, S; Inturrisi, C; Kalman, J; Mehta, D; Pappagallo, M; Perlov, E; Shaiova, L, 2008)
"Methadone is an opioid used in the management of cancer pain both in opioid naïve patients and in rotation from other opioids."8.82Methadone for cancer pain. ( Nicholson, AB, 2004)
"This article reviews the unique pharmacological properties of methadone and outlines its appropriate clinical application, with focus upon its use in the treatment of chronic pain."8.82Methadone: applied pharmacology and use as adjunctive treatment in chronic pain. ( Brown, R; Fleming, M; Kraus, C; Reddy, S, 2004)
"Methadone, although having been available for approximately half a century, is now receiving increasing attention in the management of chronic pain."8.82A review of the use of methadone for the treatment of chronic noncancer pain. ( Lynch, ME, 2005)
" Several studies have demonstrated that methadone is a valid alternative to morphine, hydromorphone, and fentanyl for the treatment of cancer-related pain, and extensive reviews on the subject have been published in recent years [10,23,25,64,70,71]."8.81The use of methadone for cancer pain. ( Bianchi, M; Ripamonti, C, 2002)
"Methadone, a synthetic opioid, has unique pharmacodynamics and pharmacokinetics, which contribute to its unique ability to relieve pain unresponsive to other potent opiates and its unique dosing and drug interactions."8.81Methadone for relief of cancer pain: a review of pharmacokinetics, pharmacodynamics, drug interactions and protocols of administration. ( Davis, MP; Walsh, D, 2001)
"In recent years a better understanding of the pharmacologic and pharmacokinetic properties of methadone, including equianalgesic ratios has led to its increased use as a second line opioid for the treatment of pain in patients with cancer."8.81Methadone use in cancer patients with pain: a review. ( Bruera, E; Sweeney, C, 2002)
" While these agents have clinical utility supported by robust literature, we the authors posit that buprenorphine is a superior therapy for both opioid use disorder (OUD) as well as pain."8.02A history of opioid abuse: Why buprenorphine is superior for the management of opioid use disorder and pain. ( Komrowski, MD; Sekhri, NK, 2021)
"One-hundred-and-sixty-four patients receiving methadone maintenance treatment completed a battery of self-report measures related to alexithymia, drug use, and pain experiences."8.02Alexithymia and pain experience among patients using methadone-maintenance therapy. ( Barry, DT; Beitel, M; Gaeta, M; Morie, KP; Oberleitner, DE; Oberleitner, LM; Potenza, MN; Roos, CR; Yip, SW, 2021)
"Many factors make methadone an appealing option for treatment of pain in patients seen by palliative care; however, complex drug-related properties and variable patient response complicate appropriate conversion ratios from other opioids to methadone."7.85Methadone Dose Selection for Treatment of Pain Compared with Consensus Recommendations. ( Ajayi, TA; Atayee, RS; Edmonds, KP; Karimian, P, 2017)
"To date there have been no studies investigating the characteristics of pain in Chinese heroin-dependent patients (HDPs) receiving methadone maintenance treatment (MMT)."7.85Prevalence of pain and its socio-demographic and clinical correlates among heroin-dependent patients receiving methadone maintenance treatment. ( Chen, WC; Lu, J; Xu, YM; Yang, YJ; Zhong, BL; Zhu, JH, 2017)
"Use of the prescription opioid methadone for treatment of pain, as opposed to treatment of opioid use disorder (e."7.83Trends in Methadone Distribution for Pain Treatment, Methadone Diversion, and Overdose Deaths - United States, 2002-2014. ( Baldwin, GT; Jones, CM; Mack, KA; Manocchio, T; White, JO, 2016)
"The use of very-low-dose methadone in conjunction with haloperidol in the acute-care setting resulted in improved pain control after conversion from typical opiates."7.81The use of very-low-dose methadone and haloperidol for pain control in the hospital setting: a preliminary report. ( Bruera, E; Buckley, JS; Buckley, NS; Salpeter, SR, 2015)
"There are few studies that describe cardiac adverse events in patients prescribed methadone for pain management."7.80Methadone for pain and the risk of adverse cardiac outcomes. ( Delate, T; Kurz, D; Price, LC; Shanahan, R; Wobeter, B, 2014)
"Previous research has reported improved pain after adding methadone to another opioid, but did not quantify this benefit using a validated outcome measure."7.79Addition of methadone to another opioid in the management of moderate to severe cancer pain: a case series. ( Bryson, J; Mak, E; Ridley, J; Wallace, E; Zimmermann, C, 2013)
"The success of rehabilitation is not influenced solely by drug abstinence, but also by the state of general health and well-being, which for patients in methadone maintenance treatment (MMT) frequently is compromised by experiencing pain, depression and sleep disorders."7.78Pain depression and sleep disorders among methadone maintenance treatment patients. ( Lawental, E; Pud, D; Zlotnick, C, 2012)
"Vital statistics data suggest that the opioid pain reliever (OPR) methadone is involved in one third of OPR-related overdose deaths, but it accounts for only a few percent of OPR prescriptions."7.78Vital signs: risk for overdose from methadone used for pain relief - United States, 1999-2010. ( , 2012)
"The reports on pain perception among former heroin addicts receiving methadone maintenance treatment (MMT) vary with regard to pain and intolerance threshold, and perception of suprathreshold stimuli has not been previously evaluated."7.77The differential effect of methadone dose and of chronic pain on pain perception of former heroin addicts receiving methadone maintenance treatment. ( Adelson, M; Defrin, R; Hetzroni, T; Peles, E; Schreiber, S, 2011)
"Differences in lifetime trauma exposure and screened symptoms of posttraumatic stress disorder (PTSD) were examined in methadone maintenance treatment (MMT) patients with a variety of pain experiences."7.77Exploring relations among traumatic, posttraumatic, and physical pain experiences in methadone-maintained patients. ( Barry, DT; Beitel, M; Cutter, CJ; Garnet, B; Joshi, D; Rosenblum, A; Schottenfeld, RS, 2011)
"The aim of this study was to examine the association of pain catastrophizing and pain coping strategies with characteristic pain intensity (an average of worst, least, and typical pain intensity in the past week) and recent pain-related disability (an average of three measures of past week pain interference) in opioid-dependent patients enrolled in a methadone maintenance treatment program (MMTP) who reported recent pain."7.77Pain catastrophizing and pain coping among methadone-maintained patients. ( Barry, DT; Beitel, M; Cutter, CJ; Garnet, B; Peters, S; Savant, J; Schottenfeld, RS, 2011)
" Our objective was to compare mortality rates among patients who received prescribed methadone or long-acting morphine for pain."7.77Comparative mortality among Department of Veterans Affairs patients prescribed methadone or long-acting morphine for chronic pain. ( Bair, MJ; Becker, WC; Hui, S; Krebs, EE; McCoy, K; Zerzan, J, 2011)
"Methadone is an effective and inexpensive opioid for cancer pain treatment."7.76Methadone initiation and rotation in the outpatient setting for patients with cancer pain. ( Bruera, E; Calderon, B; de la Cruz, M; El Osta, B; Li, Z; Palmer, JL; Parsons, HA, 2010)
"We conducted a feasibility study of sublingual methadone for breakthrough cancer pain, to determine whether a larger, randomized trial was warranted, and to identify a study design that would be likely to succeed."7.76A formal feasibility study of sublingual methadone for breakthrough cancer pain. ( Biondo, PD; Brasher, PM; Eliasziw, M; Hagen, NA; Moulin, DE; Stiles, CR; Watanabe, SM, 2010)
"Methadone is an excellent choice for pain in frail older adults."7.75Methadone: an effective, safe drug of first choice for pain management in frail older adults. ( Gallagher, R, 2009)
"Following the findings of perceived poor sleep and of chronic pain among former heroin addicts, current methadone maintenance treatment (MMT) patients, and its possible relation to methadone dose, we studied these patients' objective sleep parameters."7.75Documented poor sleep among methadone-maintained patients is associated with chronic pain and benzodiazepine abuse, but not with methadone dose. ( Adelson, M; Peles, E; Schreiber, S, 2009)
"Empirical evidence is needed to guide adequate postpartum pain relief of methadone and buprenorphine stabilized patients."7.75Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy. ( Dahne, J; Johnson, R; Jones, HE; Lemoine, L; Milio, L; O'Grady, K; Ordean, A; Selby, P, 2009)
"Differences in psychiatric distress and substance use (licit and illicit) were examined in methadone maintenance treatment (MMT) patients with a variety of pain experiences."7.75Relations among psychopathology, substance use, and physical pain experiences in methadone-maintained patients. ( Barry, DT; Beitel, M; Garnet, B; Joshi, D; Rosenblum, A; Schottenfeld, RS, 2009)
"Methadone maintained treatment (MMT) patients may be given less opioid analgesia for acute pain than the general patient, due to requests for analgesia being misinterpreted as craving for drugs."7.74Management of acute pain in methadone maintenance therapy in-patients. ( Curry, K; Fong, D; Hines, S; Theodorou, S; Williamson, A, 2008)
"The use of methadone may be difficult and its use in the treatment of chronic non-malignant pain is only sparsely described in literature, whereas several works have shown the advantage of methadone in the treatment of cancer pain."7.74[Methadone in the treatment of chronic non-malignant pain]. ( Bendiksen, A; Handberg, G; McGehee, E, 2007)
"Methadone treatment in chronic pain patients is still limited owing to misconceptions about addiction, safety, and its unique pharmacokinetic and pharmacodynamic properties."7.74Nurse case management program of chronic pain patients treated with methadone. ( Lamb, L; Pereira, JX; Shir, Y, 2007)
"Iatrogenic opioid addiction among chronic pain patients was the initiative for starting a methadone programme for pain patients at the University Hospital of Uppsala."7.73Methadone treatment of chronic non-malignant pain and opioid dependence--a long-term follow-up. ( Gordh, T; Grönbladh, L; Nilsson, LH; Rhodin, A, 2006)
"Vulnerability to delirium was potentially caused by coadministration of methadone, which can inhibit the CYP2D6 isozyme."7.73Dextromethorphan-induced delirium and possible methadone interaction. ( Lotrich, FE; Pollock, BG; Rosen, J, 2005)
"Both clinicians and researchers have expressed doubt that opiate dependent patients with significant pain can be effectively treated in methadone maintenance treatment (MMT) programs; however, little research exists on this topic."7.73Response to methadone maintenance treatment of opiate dependent patients with and without significant pain. ( Humphreys, K; Ilgen, MA; Trafton, JA, 2006)
"Twelve patients with poor pain control or unacceptable side effects during treatment with morphine were switched to methadone and followed for nine months in this open prospective study."7.73Opioid switching from oral slow release morphine to oral methadone may improve pain control in chronic non-malignant pain: a nine-month follow-up study. ( Borchgrevink, PC; Dale, O; Fredheim, OM; Kaasa, S; Klepstad, P; Landrø, NI, 2006)
"Although studies on the beliefs of persons with chronic nonmalignant pain (CNMP) are still scarce, methadone is increasingly prescribed for the treatment of CNMP."7.73Response phases in methadone treatment for chronic nonmalignant pain. ( Arnaert, A; Ciccotosto, G, 2006)
"Racemic methadone is increasingly used to manage cancer pain."7.73Pharmacokinetics and pharmacodynamics of methadone enantiomers in hospice patients with cancer pain. ( Auret, K; Boyd, F; Ilett, KF; Oh, TE; Page-Sharp, M; Roger Goucke, C, 2006)
"Methadone hydrochloride is an effective, inexpensive, and relatively safe opioid to use in the treatment of patients with chronic pain."7.73Prescribing methadone for pain management in end-of-life care. ( Manfredonia, JF, 2005)
"To estimate the prevalence and to examine the characteristics of chronic severe pain in chemically dependent populations receiving methadone maintenance or inpatient residential treatment."7.72Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities. ( Cleland, C; Fong, C; Joseph, H; Kipnis, S; Portenoy, RK; Rosenblum, A, 2003)
"To investigate the relationship between the daily dose of the synthetic opioid methadone and the corrected QT (QTc) interval in a series of methadone-treated patients who developed torsade de pointes."7.72Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes. ( Krantz, MJ; Kutinsky, IB; Mehler, PS; Robertson, AD, 2003)
"The objectives of this medico-legal case report were the following: 1) To present an example of a medico-legal problem that developed as a result of a decision to rotate a chronic pain patient (CPP) to methadone in order to taper the CPP from oxycodone; 2) To present both the plaintiff's and defendant's expert witnesses' opinions as to if and where the care of that patient fell below the "standard of medical care;" and 3) Based on these opinions, to develop some recommendations on how, in the future, pain medicine physicians and other physicians should proceed, in order to avoid allegations of breach of "standards of care" when using methadone."7.72Medico-legal rounds: medico-legal issues and alleged breaches of "standards of medical care" in opioid rotation to methadone: a case report. ( Cole, B; Cutler, RB; Fishbain, DA; Lewis, J; Rosomoff, HL; Rosomoff, RS, 2003)
"To assess the outcomes of infants born to mothers receiving methadone for the management of pain in pregnancy."7.72Outcomes of infants born to mothers receiving methadone for pain management in pregnancy. ( Kuschel, C; Sharpe, C, 2004)
"Recent studies indicate that severe chronic pain is common among patients in methadone maintenance treatment (MMT), but no qualitative studies have examined such patients' experiences of pain and pain treatment."7.72The experience of chronic severe pain in patients undergoing methadone maintenance treatment. ( Arnstein, J; Arnsten, JH; Berg, K; Gourevitch, M; Karasz, A; Selwyn, P; Zallman, L, 2004)
"To evaluate a series of methadone-treated patients experiencing torsade de pointes."7.71Torsade de pointes associated with very-high-dose methadone. ( Hays, H; Krantz, MJ; Lewkowiez, L; Mehler, PS; Robertson, AD; Woodroffe, MA, 2002)
"An expert working group of the European Association for Palliative Care has revised and updated its guidelines on the use of morphine in the management of cancer pain."7.71Morphine and alternative opioids in cancer pain: the EAPC recommendations. ( Casas, JR; Cherny, N; Conno, F; Hanks, GW; Hanna, M; Kalso, E; McQuay, HJ; Mercadante, S; Meynadier, J; Poulain, P; Radbruch, L; Ripamonti, C; Sawe, J; Twycross, RG; Ventafridda, V, 2001)
"Methadone is still regarded as a second line opioid for patients suffering from severe pain, and is rarely used in hospitalized patients."7.71Methadone is safe for treating hospitalized patients with severe pain. ( Davidson, EM; Rosen, G; Shir, Y; Zeldin, A, 2001)
"In a patient on methadone maintenance treatment, admitted for lung cancer suspicion, a slight decrease in pain dose response to morphine have necessitated adjustments of methadone treatment founded on clinical check-up and methadone assay."7.71Slow metabolism and long half life of methadone in a patient with lung cancer and cirrhosis. ( Beauverie, P; Edel, YA; Furlan, V, 2001)
"Current equianalgesic reference tables, based largely on single dose studies, give dose ratios of 1:1 to 4:1 for oral morphine to oral methadone, which possibly are inaccurate in patients with cancer pain who are exposed to multiple doses of these opioids."7.70Dose ratio between morphine and methadone in patients with cancer pain: a retrospective study. ( Bruera, ED; Hanson, J; Lawlor, PG; Turner, KS, 1998)
"Oral methadone is considered to be a valid opioid analgesic alternative to morphine and hydromorphone in treating cancer pain."7.70Equianalgesic dose/ratio between methadone and other opioid agonists in cancer pain: comparison of two clinical experiences. ( Belzile, M; Bruera, E; De Conno, F; Groff, L; Hanson, J; Pereira, J; Ripamonti, C, 1998)
"To define the dose ratio between morphine and methadone in relation to the previous morphine dose and the number of days needed to achieve the same level of analgesia in a group of patients with advanced cancer with pain who switched from morphine to oral methadone."7.70Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio? ( Brunelli, C; De Conno, F; Groff, L; Polastri, D; Ripamonti, C; Stavrakis, A, 1998)
" In the past 2 years, oral methadone has been used extensively in our institution for treating children with persistent pain from cancer, burns, or trauma who were capable of oral intake and whose pain was not relieved by nonopioid medications."7.70Oral methadone for the treatment of severe pain in hospitalized children: a report of five cases. ( Davidson, EM; Rosen, G; Shavelson, V; Shenkman, Z; Shir, Y, 1998)
"Chronic pain patients who have limited access to opioids may be redirected to methadone maintenance centers for management of their pain."7.70Characteristics of methadone maintenance patients with chronic pain. ( Jamison, RN; Katz, NP; Kauffman, J, 2000)
"We evaluated the analgesia, tolerability and absorption profile of methadone hydrochloride in six opioid-naive cancer patients with pain."7.69Rectal methadone in cancer patients with pain. A preliminary clinical and pharmacokinetic study. ( Brunelli, C; De Conno, F; Lodi, F; Ripamonti, C; Rizzio, E; Saita, L; Zecca, E, 1995)
"Five patients with chronic nonmalignant pain were transferred from other analgesics to oral methadone."7.69Oral methadone for managing chronic nonmalignant pain. ( Gardner-Nix, JS, 1996)
"The aims of this study were to describe the analgesia, side effects, and dosage and the causes of suspension of treatment in a large sample of advanced cancer patients with pain after treatment with oral methadone from 7 to 90 days."7.69Clinical experience with oral methadone administration in the treatment of pain in 196 advanced cancer patients. ( Brunelli, C; De Conno, F; Groff, L; Ripamonti, C; Ventafridda, V; Zecca, E, 1996)
"Methadone is a very effective second-line opioid for treatment of cancer pain."7.69Intravenous methadone for cancer pain unrelieved by morphine and hydromorphone: clinical observations. ( Borsook, D; Chandler, SW; Manfredi, PL; Payne, R, 1997)
"Concentrations of methadone in plasma, estimates of pain relief, and pupillary size were determined after a single intravenous dose (10 to 30 mg) of methadone hydrochloride to eight patients with chronic pain, five of whom had cancer."7.67Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain. ( Colburn, WA; Foley, KM; Houde, RW; Inturrisi, CE; Kaiko, RF, 1987)
"Forty-two cancer patients with pain and/or opioid side effects were assessed in this randomised trial."6.77Serum concentrations of opioids when comparing two switching strategies to methadone for cancer pain. ( Dale, O; Kaasa, S; Moksnes, K; Paulsen, Ø; Rosland, JH; Spigset, O, 2012)
"Providing pain management for known opioid abusers is a challenging clinical task, in part because little is known about their pain experience and analgesic requirements."6.69Pain responses in methadone-maintained opioid abusers. ( Charuvastra, VC; Compton, P; Kintaudi, K; Ling, W, 2000)
" The pharmacokinetic parameters of the R- and S-enantiomers of the racemate are reported."6.68Stereoselective pharmacokinetics of methadone in chronic pain patients. ( Angelo, HR; Blemmer, T; Christrup, LL; Drenck, NE; Kristensen, K; Rasmussen, SN; Sjøgren, P, 1996)
"Methadone is a very potent analgesic drug."6.68Pain perception of intravenous heroin users on maintenance therapy with levomethadone. ( Gastpar, M; Katta, T; Klöppel, A; Pries, E; Schall, U, 1996)
" After achieving adequate analgesia with regular dosing of oral methadone (T1), patient-controlled analgesia with methadone was administered for 3 days (T2)."6.68Opioid-sparing effect of diclofenac in cancer pain. ( Barresi, L; Caligara, M; Dardanoni, G; Mercadante, S; Sapio, M; Serretta, R, 1997)
"Up to 44% of patients with cancer-related pain require opioid rotation (OR) because of inadequate analgesia or side effects."6.52Methods of Rotation From Another Strong Opioid to Methadone for the Management of Cancer Pain: A Systematic Review of the Available Evidence. ( McLean, S; Twomey, F, 2015)
"Methadone was used subcutaneously as an analgesic agent in 1 patient."6.47Review of cancer pain management in patients receiving maintenance methadone therapy. ( McLean, S; McQuillan, R; O'Gorman, A; Rowley, D; Ryan, K, 2011)
"Methadone is a synthetic opioid with potent analgesic effects."6.43Methadone treatment for pain states. ( Kral, LA; Toombs, JD, 2005)
"Undertreatment of acute pain is suboptimal medical treatment, and patients receiving long-term OAT are at particular risk."6.43Acute pain management for patients receiving maintenance methadone or buprenorphine therapy. ( Alford, DP; Compton, P; Samet, JH, 2006)
"Ongoing assessment, multiple approaches, and excellent communication among all care management team members are critical."6.43Difficult cases in pain management: use of methadone in a multifactorial approach. ( Coyle, N; Coyne, P; Griffie, J, 2006)
"Methadone is a unique mu opioid agonist, which also has delta receptor affinity and properties of N-methyl-D-aspartate receptor antagonism and monoamine reuptake inhibition."6.43Methadone for treatment of cancer pain. ( Bryson, J; Seccareccia, D; Tamber, A; Zimmermann, C, 2006)
"Methadone is a synthetic opioid, with mu and delta receptor activity, associated with the capacity to inhibit N-methyl-D-aspartate receptors."6.41Opioid switch to oral methadone in cancer pain. ( Body, JJ; Lossignol, DA; Mancini, I, 2000)
"Methadone doses were changed according to the clinical needs to obtain the most favorable balance between analgesia and adverse effects."5.72Methadone as First-line Opioid for the Management of Cancer Pain. ( Adile, C; Bonanno, G; Casuccio, A; Ferrera, P; Mercadante, S; Pallotti, MC; Ricci, M, 2022)
"Methadone is a synthetic opioid with excellent oral bioavailability, variable, but long duration of action and extremely low cost."5.29Respiratory depression in a patient receiving oral methadone for cancer pain. ( Bruera, E; Hunt, G, 1995)
"Pain in opioid-dependent patients is common but data measuring the course of pain (and its correlates) using validated scales in patients initiating methadone treatment are sparse."5.24Pain in methadone patients: Time to address undertreatment and suicide risk (ANRS-Methaville trial). ( Bendiane, MK; Carrieri, P; Lions, C; Maradan, G; Michel, L; Mora, M; Morel, A; Nordmann, S; Roux, P; Spire, B; Vilotitch, A, 2017)
"Methadone is a potent analgesic used to treat refractory cancer pain."5.24Can Saliva and Plasma Methadone Concentrations Be Used for Enantioselective Pharmacokinetic and Pharmacodynamic Studies in Patients With Advanced Cancer? ( George, R; Good, P; Hardy, J; Haywood, A; Hennig, S; Khan, S; Norris, R, 2017)
" There is little information on methadone use for SCD pain."5.22Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease. ( Deych, E; Frei-Jones, M; Horst, J; Kharasch, ED; Shannon, W, 2016)
"Propofol and isoflurane requirements and preoperative pain scores were not different between groups."5.17Comparison of perioperative analgesic efficacy between methadone and butorphanol in cats. ( Bauquier, SH; Beths, T; Holm, M; Warne, LN, 2013)
"This analysis explored the prevalence and correlates of pain in patients enrolled in methadone maintenance treatment (MMT)."5.17Epidemiology of pain among outpatients in methadone maintenance treatment programs. ( Dhingra, L; Homel, P; Jordan, AE; Katz, J; Masson, C; McKnight, C; Perlman, DC; Portenoy, RK; Seewald, RM; Wald, E; Young, C, 2013)
"This study was designed to evaluate the role of epidural methadone-lidocaine in cancer pain combined or not to epidural dexamethasone."5.17Epidural methadone results in dose-dependent analgesia in cancer pain, further enhanced by epidural dexamethasone. ( Lauretti, GR; Mattos, AL; Rizzo, CC; Rodrigues, SW, 2013)
"Data on the treatment of breakthrough cancer pain (BTcP) in patients receiving methadone therapy are lacking."5.15The use of fentanyl buccal tablets as breakthrough medication in patients receiving chronic methadone therapy: an open label preliminary study. ( Arcuri, E; Ferrera, P; Mercadante, S, 2011)
"The SAG patients reported a trend of more pain, had significantly more dropouts and three SAEs, which indicate that the SAG strategy should not replace the 3DS when switching from high doses of morphine or oxycodone to methadone."5.15How to switch from morphine or oxycodone to methadone in cancer patients? a randomised clinical phase II trial. ( Dale, O; Kaasa, S; Klepstad, P; Moksnes, K; Paulsen, O; Rosland, JH, 2011)
"Methadone was administered to 21 opioid-tolerant cancer patients because of pain (numerical rating scale [NRS] > 5) on morphine (ten patients), transdermal fentanyl (TF; four patients), morphine, ketamine, and TF (one patient), tramadol (one patient), pethidine (one patient), pain with drowsiness on morphine with ketamine (three patients), and pain with nausea on morphine (one patient)."5.14The role of methadone in opioid rotation-a Polish experience. ( Leppert, W, 2009)
"This study aims to evaluate the efficacy of methadone as substitute for morphine and to investigate if the addition of acetaminophen could reduce the time to attain an equianalgesic dose of methadone and/or to improve the level of pain control in oncologic patients."5.14Early switching from morphine to methadone is not improved by acetaminophen in the analgesia of oncologic patients: a prospective, randomized, double-blind, placebo-controlled study. ( Cubero, DI; del Giglio, A, 2010)
"The purpose of this study was to determine the effect of initiation of methadone on QTc interval in patients with cancer pain seen at the palliative care setting."5.14The effect of oral methadone on the QTc interval in advanced cancer patients: a prospective pilot study. ( Bruera, E; de la Cruz, M; El Osta, B; Hui, D; Palmer, JL; Reddy, S; Walker, P, 2010)
"The objective of the study was to describe the experience of methadone use in 100 consecutive chronic pain patients managed in a single multidisciplinary center."5.13Experience of methadone therapy in 100 consecutive chronic pain patients in a multidisciplinary pain center. ( Evans, D; Galonski, M; Gordon, A; Gourlay, D; Peng, P; Stafford, M; Tumber, P; Wong, P, 2008)
"The treatment of acute pain in patients maintained on methadone is difficult due to increased pain sensitivity (hyperalgesia) and cross-tolerance to other opioids."5.13Antinociceptive effects of high-dose remifentanil in male methadone-maintained patients. ( Bochner, F; Hay, JL; Somogyi, AA; White, JM, 2008)
"To compare the effectiveness and side effects of methadone and morphine as first-line treatment with opioids for cancer pain."5.11Methadone versus morphine as a first-line strong opioid for cancer pain: a randomized, double-blind study. ( Bertolino, M; Bosnjak, S; Bruera, E; Fisch, MJ; Mathias, C; Moyano, J; Palmer, JL; Rico, MA; Spruyt, O; Strasser, F; Sweeney, C; Willey, J, 2004)
"Methadone is effective for chronic cancer pain, but its early pharmacodynamic profile and effectiveness for breakthrough pain remain uncertain."5.11Characterization of the early pharmacodynamic profile of oral methadone for cancer-related breakthrough pain: a pilot study. ( Fisher, K; Hagen, NA; Stiles, C, 2004)
"The aim of this study is to characterize patients with chronic pain in methadone maintenance treatment (MMT)."5.11Significantly higher methadone dose for methadone maintenance treatment (MMT) patients with chronic pain. ( Adelson, M; Gordon, J; Peles, E; Schreiber, S, 2005)
"Methadone is a strong opioid analgesic that has been used successfully in cancer pain management."5.11Intermittent subcutaneous methadone administration in the management of cancer pain. ( Centeno, C; Vara, F, 2005)
"This prospective study documents the use of methadone as part of an opioid rotation strategy in patients with uncontrolled pain and severe delirium admitted for terminal care to a tertiary cancer palliative care hospital."5.11Methadone in the treatment of pain and terminal delirum in advanced cancer patients. ( Comfort, C; Kogan, M; Moryl, N; Obbens, E, 2005)
"The successful use of methadone in cancer pain has been supported by numerous case reports and clinical studies."5.10Pitfalls of opioid rotation: substituting another opioid for methadone in patients with cancer pain. ( Derby, S; Fischberg, D; Kornick, C; Manfredi, PL; Moryl, N; Payne, R; Santiago-Palma, J, 2002)
"To assess the use of methadone in patients with cancer pain who fail to respond to increasing doses of other opioids or experience intolerable side-effects from them."5.09Methadone titration in opioid-resistant cancer pain. ( Gonty, N; Scholes, CF; Trotman, IF, 1999)
"The use of methadone in the treatment of cancer pain is becoming more attractive mainly because of its known efficacy, lack of active metabolites, and low cost."5.09Differences in the ratios of morphine to methadone in patients with neuropathic pain versus non-neuropathic pain. ( Bruera, E; Gagnon, B, 1999)
"Fifty-two consecutive cancer patients receiving oral morphine but with uncontrolled pain and/or moderate to severe opioid adverse effects were switched to oral methadone administered every 8 hours using different dose ratios."5.09Switching from morphine to methadone to improve analgesia and tolerability in cancer patients: a prospective study. ( Boffi, R; Casuccio, A; Fulfaro, F; Gebbia, V; Groff, L; Mercadante, S; Ripamonti, C; Villari, P, 2001)
"In a prospective, open study, 37 advanced cancer patients in poor pain control receiving high doses of subcutaneous hydromorphone (mean daily dose: 276 +/- 163 mg) were switched to methadone by use of custom-made capsules (21 patients) or suppositories (16 patients)."5.08Custom-made capsules and suppositories of methadone for patients on high-dose opioids for cancer pain. ( Bruera, E; Fainsinger, RL; Inturrisi, C; Spachynski, K; Suarez-Almazor, M; Watanabe, S, 1995)
"Methadone is a very useful drug in cancer pain because of its low cost, lack of active metabolites, high oral availability, and the rapid onset of its analgesic effect."5.08Patient-controlled analgesia with oral methadone in cancer pain: preliminary report. ( Caligara, M; Mercadante, S; Sapio, M; Serretta, R, 1996)
"To determine the relationship between changes in plasma methadone concentration and pharmacodynamic effects, plasma methadone profiles and pharmacodynamics (analgesia and sedation) were measured during and after the continuous infusion of methadone for 180 to 270 minutes in 15 patients with pain caused by cancer."5.06Pharmacokinetic-pharmacodynamic relationships of methadone infusions in patients with cancer pain. ( Colburn, WA; Foley, KM; Inturrisi, CE; Max, MB; Portenoy, RK, 1990)
"Eighteen patients suffering from cancer were entered into a study of the pharmacokinetics and efficacy of methadone and morphine in pain control."5.06A comparative study of the efficacy and pharmacokinetics of oral methadone and morphine in the treatment of severe pain in patients with cancer. ( Cherry, DA; Cousins, MJ; Gourlay, GK, 1986)
"This study reports the results of a double-blind, parallel-group comparison of intravenous methadone with morphine for the control of postoperative pain."5.06A double-blind comparison of the efficacy of methadone and morphine in postoperative pain control. ( Gourlay, GK; Lamberty, J; Willis, RJ, 1986)
"Methadone, due to its multimechanistic action profile, is possibly among the most effective and most underutilized opioid analgesics in children with severe unrelieved pain at end of life."5.01From Tramadol to Methadone: Opioids in the Treatment of Pain and Dyspnea in Pediatric Palliative Care. ( Friedrichsdorf, SJ, 2019)
"Methadone is a valuable opioid in the management of patients who have cancer with pain."4.98Methadone: Maximizing Safety and Efficacy for Pain Control in Patients with Cancer. ( Costantino, RC; McPherson, AL; McPherson, ML, 2018)
"We included all studies of methadone used to facilitate weaning from continuous opioid infusions in pediatric critical care patients, including medical, cardiac, and surgical patients, excluding case reports and studies treating neonatal abstinence syndrome, or acute or chronic pain."4.95The use of methadone to facilitate opioid weaning in pediatric critical care patients: a systematic review of the literature and meta-analysis. ( Dervan, LA; Watson, RS; Wolf, FM; Yaghmai, B, 2017)
"To determine the effectiveness and tolerability of methadone as an analgesic in adults and children with cancer pain."4.95Methadone for cancer pain. ( Derry, S; Nicholson, AB; Watson, GR; Wiffen, PJ, 2017)
"The proven therapeutic efficacy of methadone in cancer pain is hindered by a challenging pharmacokinetic-pharmacodynamic profile, considerable interpatient variation, and increasing concern about the complexities of dosing."4.90Therapeutic challenges in cancer pain management: a systematic review of methadone. ( Afsharimani, B; Good, P; Hardy, J; Haywood, A; Khan, S; Movva, R, 2014)
"Methadone and buprenorphine are maintenance replacement therapies for opioid dependence; they are also used for pain management."4.89Metabolic and toxicological considerations of the opioid replacement therapy and analgesic drugs: methadone and buprenorphine. ( Moody, DE, 2013)
"To determine the analgesic efficacy of transdermal fentanyl for relief of cancer pain, and to assess the adverse events associated with the use of transdermal fentanyl for relief of cancer pain."4.89Transdermal fentanyl for cancer pain. ( Derry, S; Hadley, G; Moore, RA; Wiffen, PJ, 2013)
"For the past 20 years, methadone has been experiencing resurgence in the palliative care community as a second-line opioid for the treatment of cancer pain."4.87Morphine to methadone conversion: an interpretation of published data. ( Baumrucker, SJ; Morgan, V; Pollock, AB; Tegeler, ML, 2011)
"Methadone was responsible for the most deaths at 10 (50%), and hydrocodone was second at four deaths (20%) The most common risk factors found in the medical records of decedents included prescriber error in initiating, converting or titrating doses, patient nonadherence to medical instruction, presence of comorbid mental disorders, toxicological presence of benzodiazepines, middle age, and unrelieved pain."4.87A review of forensic implications of opioid prescribing with examples from malpractice cases involving opioid-related overdose. ( Rich, BA; Webster, LR, 2011)
"Methadone is highly effective in treating opioid dependence, and it is also used as an analgesic for second-line management of chronic pain."4.86Methadone deaths: risk factors in pain and addicted populations. ( Brooks, D; Modesto-Lowe, V; Petry, N, 2010)
"Methadone is increasingly prescribed for chronic pain, yet the associated mortality appears to be rising disproportionately relative to other opioid analgesics."4.85Methadone-induced mortality in the treatment of chronic pain: role of QT prolongation. ( Andrews, CM; Capacchione, JF; Haigney, MC; Krantz, MJ; Marcuson, MJ; Wedam, EF, 2009)
"To summarize the unique characteristics of methadone and the putative mechanisms of rapid-onset opioid formulations for breakthrough pain; to outline the principles underlying opioid rotation; and to describe elements of risk assessment in opioid therapy."4.85Clinical approaches to special issues related to opioid therapy. ( Fine, PG, 2009)
"To outline pharmacodynamics, pharmacokinetics, drug interactions, equianalgesic dose ratio with other opioids, dosing rules, adverse effects and methadone clinical studies in patients with cancer pain."4.85The role of methadone in cancer pain treatment--a review. ( Leppert, W, 2009)
" Alternative approaches with methadone, ketamine, or local anesthetics should be considered."4.84Pharmacological approaches to the management of pain in the neonatal intensive care unit. ( Anand, KJ, 2007)
"Methadone is an opioid used in the management of cancer pain."4.84Methadone for cancer pain. ( Nicholson, AB, 2007)
"This topical review addresses methadone's pharmacology, its application in malignant and non-malignant pain conditions, practical issues related to methadone for the treatment of pain and its influence on QTc time."4.84Clinical pharmacology of methadone for pain. ( Borchgrevink, PC; Dale, O; Fredheim, OM; Kaasa, S; Moksnes, K, 2008)
"Methadone, an opioid analgesic, is used clinically in pain therapy as well as for substitution therapy in opioid addiction."4.84Interindividual variability of methadone response: impact of genetic polymorphism. ( Davani, S; Gerritsen-van Schieveen, P; Kantelip, JP; Li, Y, 2008)
"Once used only as third-line therapy for chronic pain management, methadone is now being used as first- and second-line therapy in palliative care."4.84Consensus guideline on parenteral methadone use in pain and palliative care. ( Berger, A; Blinderman, CD; Bruera, E; Davis, MP; Derby, S; Inturrisi, C; Kalman, J; Mehta, D; Pappagallo, M; Perlov, E; Shaiova, L, 2008)
" Evidence presented in this review shows encouraging results following the administration of methadone, fentanyl or ketamine to patients with difficult pain problems."4.82Morphine is not the only analgesic in palliative care: literature review. ( Wootton, M, 2004)
"Methadone is an opioid used in the management of cancer pain both in opioid naïve patients and in rotation from other opioids."4.82Methadone for cancer pain. ( Nicholson, AB, 2004)
"This article reviews the unique pharmacological properties of methadone and outlines its appropriate clinical application, with focus upon its use in the treatment of chronic pain."4.82Methadone: applied pharmacology and use as adjunctive treatment in chronic pain. ( Brown, R; Fleming, M; Kraus, C; Reddy, S, 2004)
"Methadone, although having been available for approximately half a century, is now receiving increasing attention in the management of chronic pain."4.82A review of the use of methadone for the treatment of chronic noncancer pain. ( Lynch, ME, 2005)
"Methadone is a synthetic opioid that is effective for the relief of moderate-to-severe pain and for the treatment of opioid dependence."4.82Pharmacokinetics of methadone. ( Kern, SE; Lugo, RA; Satterfield, KL, 2005)
" Several studies have demonstrated that methadone is a valid alternative to morphine, hydromorphone, and fentanyl for the treatment of cancer-related pain, and extensive reviews on the subject have been published in recent years [10,23,25,64,70,71]."4.81The use of methadone for cancer pain. ( Bianchi, M; Ripamonti, C, 2002)
"Methadone hydrochloride is a mu-opioid agonist that has been used for the treatment of pain and for the management and maintenance of opioid withdrawal for over 50 years."4.81Clinical use of methadone. ( Goode, JV; Layson-Wolf, C; Small, RE, 2002)
"Methadone, a synthetic opioid, has unique pharmacodynamics and pharmacokinetics, which contribute to its unique ability to relieve pain unresponsive to other potent opiates and its unique dosing and drug interactions."4.81Methadone for relief of cancer pain: a review of pharmacokinetics, pharmacodynamics, drug interactions and protocols of administration. ( Davis, MP; Walsh, D, 2001)
"In recent years a better understanding of the pharmacologic and pharmacokinetic properties of methadone, including equianalgesic ratios has led to its increased use as a second line opioid for the treatment of pain in patients with cancer."4.81Methadone use in cancer patients with pain: a review. ( Bruera, E; Sweeney, C, 2002)
"From August 2021 to March 2022, a pharmacist guided implementation of a pilot sOAT protocol consisting of escalating doses of oxycodone or oral hydromorphone scheduled every four hours, intravenous hydromorphone as needed, and non-opioid adjuvants for withdrawal and pain."4.31Safety and preliminary outcomes of short-acting opioid agonist treatment (sOAT) for hospitalized patients with opioid use disorder. ( Caputo, A; Christopher, C; Compton, P; Delgado, MK; Lowenstein, M; McFadden, R; Olenik, JM; Perrone, J; Ronning, K; Sigueza, AL; Thakrar, AP; Uritsky, TJ; Winston, A, 2023)
" Among those on methadone or buprenorphine (N = 108), multivariable logistic regression models examined the association between socio-demographics, MOUD type; and past-30-day use of heroin/fentanyl; crack; benzodiazepines; and pain medications."4.31Drug use patterns and factors related to the use and discontinuation of medications for opioid use disorder in the age of fentanyl: findings from a mixed-methods study of people who use drugs. ( Case, P; Green, TC; Hughto, JMW; Moyo, P; Palacios, WR; Rapisarda, SS; Silcox, J; Stopka, TJ; Tapper, A, 2023)
"Slow-release oral morphine (SROM) is used to manage pain, and as opioid agonist treatment (OAT)."4.31Assessing the impact of the slow-release oral morphine drug shortages in Ontario, Canada: A population-based time series analysis. ( Besharah, J; Campbell, T; Gomes, T; Kleinman, RA; Kolla, G; Ledlie, S; Leece, P; McCormack, D; Smoke, A; Sproule, B; Tadrous, M, 2023)
" There was a significant decrease in propofol and fentanyl utilization from 24 hours pretracheostomy to 24 hours posttracheostomy in both dose and number of patients receiving these continuous intravenous medications."4.12Tracheostomy decreases continuous analgesia and sedation requirements. ( Droege, CA; Elson, NC; Goodman, MD; Hayes, HV; Nomellini, V; Pritts, TA; Salvator, A; Singer, KE; Wallen, TE, 2022)
" This patient was taking methadone for neoplasm related pain."4.12Lucid Dreams Associated with Pregabalin: Implications for Clinical Practice. ( Chang, YD; Craig, DS; Guastella, AM; Haas, MF; Latchman, J, 2022)
" Opioid exposure during pregnancy included 16 202 pregnancies exposed to codeine, 4540 to oxycodone, 1244 to tramadol, 260 to methadone (dispensed for pain), 90 to hydromorphone, and 63 to morphine compared with 25 710 exposed to hydrocodone."4.12Characteristics of Prescription Opioid Analgesics in Pregnancy and Risk of Neonatal Opioid Withdrawal Syndrome in Newborns. ( Bateman, BT; Esposito, DB; Hernández-Díaz, S; Huybrechts, KF; Mogun, H; Straub, L; Werler, MM, 2022)
"Methadone is an evidence-based treatment for opioid use disorder (OUD) and pain management."4.12Pronounced Regional Disparities in United States Methadone Distribution. ( Furst, JA; McCall, KL; Mynarski, NJ; Piper, BJ, 2022)
" Of the seven articles, all seven reported some improvement in pain with the addition of low-dose or adjuvant methadone."4.12Efficacy of low-dose and/or adjuvant methadone in palliative medicine. ( Chalker, C; Cranfield, F; O'Neill, H, 2022)
" While these agents have clinical utility supported by robust literature, we the authors posit that buprenorphine is a superior therapy for both opioid use disorder (OUD) as well as pain."4.02A history of opioid abuse: Why buprenorphine is superior for the management of opioid use disorder and pain. ( Komrowski, MD; Sekhri, NK, 2021)
"One-hundred-and-sixty-four patients receiving methadone maintenance treatment completed a battery of self-report measures related to alexithymia, drug use, and pain experiences."4.02Alexithymia and pain experience among patients using methadone-maintenance therapy. ( Barry, DT; Beitel, M; Gaeta, M; Morie, KP; Oberleitner, DE; Oberleitner, LM; Potenza, MN; Roos, CR; Yip, SW, 2021)
"Methadone is an effective medication for treating pain and has unique characteristics that require specialized knowledge to prescribe safely."4.02Methadone for Palliative Care Providers: A Case-Based Flipped Classroom Module for Faculty and Fellows. ( Biewald, MA; Lindenberger, E; Scarborough, B, 2021)
"Methadone is a complex but useful medication for pain management in palliative care."3.96Comparing Methadone Rotation to Consensus Opinion. ( Quirk, KC; Rodgers, PE; Saul, DC; Silveira, MJ; Smith, MA, 2020)
"Methadone has several unique characteristics that make it an attractive option for pain relief in serious illness, but the safety of methadone has been called into question after reports of a disproportionate increase in opioid-induced deaths in recent years."3.91Safe and Appropriate Use of Methadone in Hospice and Palliative Care: Expert Consensus White Paper. ( Bemben, NM; Bruera, E; Chou, R; Davis, MP; Lapointe, BJ; Lockman, DK; Malotte, K; McPherson, ML; Paice, J; Ray, JB; Reddy, A; Salpeter, S; Walker, KA; Wellman, C, 2019)
" In light of the ongoing opioid epidemic, the purpose of the current study was to understand the prevalence and health-related correlates of loss of control (LOC) eating in adults seeking methadone maintenance treatment primarily for addiction to heroin and/or painkillers."3.88Prevalence and Correlates of Loss of Control Eating among Adults Presenting for Methadone Maintenance Treatment. ( Bond, DS; Bryson, WC; Cotton, BP; Goldschmidt, AB; Laurent, J; Mackey, S, 2018)
" Methadone is an opioid prescribed for pain management and is also provided through opioid treatment programs to treat opioid use disorders."3.85Methadone Prescribing and Overdose and the Association with Medicaid Preferred Drug List Policies - United States, 2007-2014. ( Alexander, C; Bohm, M; Faul, M, 2017)
"Methadone use as a second-line agent for severe cancer-related pain is increasing in the field of hospice and palliative care."3.85Methadone-Induced Neurotoxicity in Advanced Cancer: A Case Report. ( Hartwig, KN; Hoff, AM; Rosielle, DA, 2017)
"Many factors make methadone an appealing option for treatment of pain in patients seen by palliative care; however, complex drug-related properties and variable patient response complicate appropriate conversion ratios from other opioids to methadone."3.85Methadone Dose Selection for Treatment of Pain Compared with Consensus Recommendations. ( Ajayi, TA; Atayee, RS; Edmonds, KP; Karimian, P, 2017)
"To date there have been no studies investigating the characteristics of pain in Chinese heroin-dependent patients (HDPs) receiving methadone maintenance treatment (MMT)."3.85Prevalence of pain and its socio-demographic and clinical correlates among heroin-dependent patients receiving methadone maintenance treatment. ( Chen, WC; Lu, J; Xu, YM; Yang, YJ; Zhong, BL; Zhu, JH, 2017)
"Use of the prescription opioid methadone for treatment of pain, as opposed to treatment of opioid use disorder (e."3.83Trends in Methadone Distribution for Pain Treatment, Methadone Diversion, and Overdose Deaths - United States, 2002-2014. ( Baldwin, GT; Jones, CM; Mack, KA; Manocchio, T; White, JO, 2016)
"Methadone offers many advantages for treating cancer pain."3.83Methadone as a Coanalgesic for Palliative Care Cancer Patients. ( Courtemanche, F; Dao, D; Gagné, F; Néron, A; Tremblay, L, 2016)
"The use of very-low-dose methadone in conjunction with haloperidol in the acute-care setting resulted in improved pain control after conversion from typical opiates."3.81The use of very-low-dose methadone and haloperidol for pain control in the hospital setting: a preliminary report. ( Bruera, E; Buckley, JS; Buckley, NS; Salpeter, SR, 2015)
"Pregnant women filling at least one prescription for an opioid analgesic at any time during pregnancy for whom opioid exposure characteristics including duration of therapy: short term (<30 days) or long term (≥ 30 days); timing of use: early use (only in the first two trimesters) or late use (extending into the third trimester); and cumulative dose (in morphine equivalent milligrams) were assessed."3.81Exposure to prescription opioid analgesics in utero and risk of neonatal abstinence syndrome: population based cohort study. ( Bateman, BT; Desai, RJ; Hernandez-Diaz, S; Huybrechts, KF; Kaltenbach, K; Kerzner, LS; Mogun, H; Patorno, E, 2015)
"Antinociceptive effect of narcotic analgesics, fentanyl, oxycodone and methadone in inflammatory pain state was described in the von Frey filament test using the complete Freund's adjuvant (CFA)-induced mouse inflammatory pain model."3.80Differential alternation of the antinociceptive effect of narcotic analgesics on the inflammatory pain state. ( Aoki, Y; Mizoguchi, H; Sakurada, S; Sakurada, T; Watanabe, C, 2014)
"There are few studies that describe cardiac adverse events in patients prescribed methadone for pain management."3.80Methadone for pain and the risk of adverse cardiac outcomes. ( Delate, T; Kurz, D; Price, LC; Shanahan, R; Wobeter, B, 2014)
"We describe a child with acute myeloid leukemia (AML) who developed severe central sleep apnea (CSA) on methadone therapy for chronic pain management."3.79Severe central sleep apnea in a child with leukemia on chronic methadone therapy. ( Amos, LB; D'Andrea, LA, 2013)
"The responses pertaining to opioid agreements, urine drug testing, acetaminophen, and treatment for neuropathic pain are reassuring in that they prevent misuse and abuse of opioids, prevent acetaminophen-induced hepatotoxicity, and reflect evidence-based treatments."3.79Prescription patterns of pain medicine physicians. ( Avram, MJ; Benzon, HA; Benzon, HT; Cox, P; Dean, K; Katz, JA; Kendall, MC; Malik, K, 2013)
"Previous research has reported improved pain after adding methadone to another opioid, but did not quantify this benefit using a validated outcome measure."3.79Addition of methadone to another opioid in the management of moderate to severe cancer pain: a case series. ( Bryson, J; Mak, E; Ridley, J; Wallace, E; Zimmermann, C, 2013)
" This study explores the correlates of depression among a sample of methadone maintained treatment (MMT) adults in the Los Angeles area, and is part of a larger study on hepatitis health promotion among MMT clients who use alcohol."3.78Correlates of depressive symptoms among alcohol-using methadone maintained adults. ( Albarrán, CR; Branson, C; Khalilifard, F; Leake, B; Marfisee, M; Nyamathi, A, 2012)
"Opioid switching to methadone is reported frequently to improve pain control in patients with an unacceptable balance between pain control and side effects during treatment with first line opioids, but carries a risk of drug accumulation and respiratory depression."3.78Opioid switching to methadone: a pharmacoepidemiological study from a national prescription database. ( Borchgrevink, PC; Fredheim, OM; Moksnes, K; Skurtveit, S, 2012)
"A retrospective, systematic chart review of levo-methadone conversions for the treatment of pain in inpatient palliative care was performed."3.78Practicability, safety, and efficacy of a "German model" for opioid conversion to oral levo-methadone. ( Gaertner, J; Klein, C; Nauck, F; Ostgathe, C; Sabatowski, R; Van Aaaken, A; Voltz, R, 2012)
"Switching to methadone from different opioids, using an initial fixed ratio followed by a flexible dosing, according to the clinical need, is highly effective and safe when performed in an acute pain relief and palliative care unit."3.78Switching methadone: a 10-year experience of 345 patients in an acute palliative care unit. ( Mercadante, S, 2012)
"The success of rehabilitation is not influenced solely by drug abstinence, but also by the state of general health and well-being, which for patients in methadone maintenance treatment (MMT) frequently is compromised by experiencing pain, depression and sleep disorders."3.78Pain depression and sleep disorders among methadone maintenance treatment patients. ( Lawental, E; Pud, D; Zlotnick, C, 2012)
"Vital statistics data suggest that the opioid pain reliever (OPR) methadone is involved in one third of OPR-related overdose deaths, but it accounts for only a few percent of OPR prescriptions."3.78Vital signs: risk for overdose from methadone used for pain relief - United States, 1999-2010. ( , 2012)
"The reports on pain perception among former heroin addicts receiving methadone maintenance treatment (MMT) vary with regard to pain and intolerance threshold, and perception of suprathreshold stimuli has not been previously evaluated."3.77The differential effect of methadone dose and of chronic pain on pain perception of former heroin addicts receiving methadone maintenance treatment. ( Adelson, M; Defrin, R; Hetzroni, T; Peles, E; Schreiber, S, 2011)
"Differences in lifetime trauma exposure and screened symptoms of posttraumatic stress disorder (PTSD) were examined in methadone maintenance treatment (MMT) patients with a variety of pain experiences."3.77Exploring relations among traumatic, posttraumatic, and physical pain experiences in methadone-maintained patients. ( Barry, DT; Beitel, M; Cutter, CJ; Garnet, B; Joshi, D; Rosenblum, A; Schottenfeld, RS, 2011)
"The aim of this study was to examine the association of pain catastrophizing and pain coping strategies with characteristic pain intensity (an average of worst, least, and typical pain intensity in the past week) and recent pain-related disability (an average of three measures of past week pain interference) in opioid-dependent patients enrolled in a methadone maintenance treatment program (MMTP) who reported recent pain."3.77Pain catastrophizing and pain coping among methadone-maintained patients. ( Barry, DT; Beitel, M; Cutter, CJ; Garnet, B; Peters, S; Savant, J; Schottenfeld, RS, 2011)
" Our objective was to compare mortality rates among patients who received prescribed methadone or long-acting morphine for pain."3.77Comparative mortality among Department of Veterans Affairs patients prescribed methadone or long-acting morphine for chronic pain. ( Bair, MJ; Becker, WC; Hui, S; Krebs, EE; McCoy, K; Zerzan, J, 2011)
"A case of severe constipation is described in a 75-year- old cancer patient receiving methadone for pain."3.77Neostigmine for the treatment of gastrointestinal atony: a report of one case. ( Papa, P; Turconi, L, 2011)
"We have demonstrated previously that former opiate-dependent subjects treated and detoxified from methadone maintenance therapy suffer deficits in neuropsychological performance and have abnormal pain thresholds."3.77The effect of pain on stroop performance in patients with opiate dependence in sustained remission. ( Aniskin, DB; Boda, N; Cohen, LJ; Fink, E; Galynker, II; Prosser, J; Steinfeld, M, 2011)
"Methadone is a long-acting opioid used in the treatment of various pain states and substitution therapy in heroin addiction."3.77Characterization of the antinociceptive effects of the individual isomers of methadone after acute and chronic administrations. ( Morgan, RW; Nicholson, KL, 2011)
"This study found no differences in the pain responses of ME infants and non-exposed infants when given sucrose during heel lance procedures."3.76Efficacy of oral sucrose in infants of methadone-maintained mothers. ( Marceau, JR; Murray, H; Nanan, RK, 2010)
"Methadone is an effective and inexpensive opioid for cancer pain treatment."3.76Methadone initiation and rotation in the outpatient setting for patients with cancer pain. ( Bruera, E; Calderon, B; de la Cruz, M; El Osta, B; Li, Z; Palmer, JL; Parsons, HA, 2010)
"We conducted a feasibility study of sublingual methadone for breakthrough cancer pain, to determine whether a larger, randomized trial was warranted, and to identify a study design that would be likely to succeed."3.76A formal feasibility study of sublingual methadone for breakthrough cancer pain. ( Biondo, PD; Brasher, PM; Eliasziw, M; Hagen, NA; Moulin, DE; Stiles, CR; Watanabe, SM, 2010)
"This observational study aimed to determine whether pain sensitivity in patients with noncancer chronic pain, taking either methadone or morphine, is similar to patients maintained on methadone for dependence therapy, compared with a control group."3.75Hyperalgesia in opioid-managed chronic pain and opioid-dependent patients. ( Bochner, F; Hay, JL; Rounsefell, B; Semple, TJ; Somogyi, AA; White, JM, 2009)
" We sought first to explore providers' perceptions of ambiguity, and then to examine their strategies for making diagnostic and treatment decisions to manage chronic pain among patients on methadone maintenance therapy."3.75Providers' experiences treating chronic pain among opioid-dependent drug users. ( Arnsten, JH; Berg, KM; Karasz, A; Sacajiu, G, 2009)
"Methadone is an excellent choice for pain in frail older adults."3.75Methadone: an effective, safe drug of first choice for pain management in frail older adults. ( Gallagher, R, 2009)
"Methadone is often used as an alternative for pain management."3.75Methadone antinociception is dependent on peripheral opioid receptors. ( He, L; Kim, J; McFadden, W; Ou, C; van Rijn, RM; Whistler, JL, 2009)
"Following the findings of perceived poor sleep and of chronic pain among former heroin addicts, current methadone maintenance treatment (MMT) patients, and its possible relation to methadone dose, we studied these patients' objective sleep parameters."3.75Documented poor sleep among methadone-maintained patients is associated with chronic pain and benzodiazepine abuse, but not with methadone dose. ( Adelson, M; Peles, E; Schreiber, S, 2009)
"Empirical evidence is needed to guide adequate postpartum pain relief of methadone and buprenorphine stabilized patients."3.75Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy. ( Dahne, J; Johnson, R; Jones, HE; Lemoine, L; Milio, L; O'Grady, K; Ordean, A; Selby, P, 2009)
"Differences in psychiatric distress and substance use (licit and illicit) were examined in methadone maintenance treatment (MMT) patients with a variety of pain experiences."3.75Relations among psychopathology, substance use, and physical pain experiences in methadone-maintained patients. ( Barry, DT; Beitel, M; Garnet, B; Joshi, D; Rosenblum, A; Schottenfeld, RS, 2009)
"To investigate the possibility of utilizing the ratio of the methadone metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), to urine creatinine to develop a regression model that would predict drug adherence in patients prescribed methadone for either pain management or drug addiction."3.75Quantification of a methadone metabolite (EDDP) in urine: assessment of compliance. ( Larson, ME; Richards, TM, 2009)
" Chronic intrathecal morphine or methadone significantly increased spinal glial activation (toll-like receptor 4 mRNA and protein) and the expression of multiple chemokines and cytokines, combined with development of analgesic tolerance and pain enhancement (hyperalgesia, allodynia)."3.74Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. ( Baker, EM; Coats, BD; Hutchinson, MR; Jekich, BM; Judd, CM; Lewis, SS; Maier, SF; Martin, D; Poole, S; Rezvani, N; Somogyi, AA; Sprunger, DB; Watkins, LR; Wieseler, JL; Zhang, Y, 2008)
"Methadone maintained treatment (MMT) patients may be given less opioid analgesia for acute pain than the general patient, due to requests for analgesia being misinterpreted as craving for drugs."3.74Management of acute pain in methadone maintenance therapy in-patients. ( Curry, K; Fong, D; Hines, S; Theodorou, S; Williamson, A, 2008)
"The use of methadone may be difficult and its use in the treatment of chronic non-malignant pain is only sparsely described in literature, whereas several works have shown the advantage of methadone in the treatment of cancer pain."3.74[Methadone in the treatment of chronic non-malignant pain]. ( Bendiksen, A; Handberg, G; McGehee, E, 2007)
"Methadone treatment in chronic pain patients is still limited owing to misconceptions about addiction, safety, and its unique pharmacokinetic and pharmacodynamic properties."3.74Nurse case management program of chronic pain patients treated with methadone. ( Lamb, L; Pereira, JX; Shir, Y, 2007)
"Among the many patients served by methadone maintenance treatment programs (MMTPs) is a small population with severe, refractory pain that may be effectively managed using long-term opioid therapy."3.74MMTP patients with chronic pain switching to pain management clinics. A problem or an acceptable practice? ( Altilio, T; Bookbinder, M; Cruciani, RA; Esteban, S; Portenoy, RK; Seewald, RM; Sheu, R, 2008)
"Iatrogenic opioid addiction among chronic pain patients was the initiative for starting a methadone programme for pain patients at the University Hospital of Uppsala."3.73Methadone treatment of chronic non-malignant pain and opioid dependence--a long-term follow-up. ( Gordh, T; Grönbladh, L; Nilsson, LH; Rhodin, A, 2006)
"Vulnerability to delirium was potentially caused by coadministration of methadone, which can inhibit the CYP2D6 isozyme."3.73Dextromethorphan-induced delirium and possible methadone interaction. ( Lotrich, FE; Pollock, BG; Rosen, J, 2005)
"Both clinicians and researchers have expressed doubt that opiate dependent patients with significant pain can be effectively treated in methadone maintenance treatment (MMT) programs; however, little research exists on this topic."3.73Response to methadone maintenance treatment of opiate dependent patients with and without significant pain. ( Humphreys, K; Ilgen, MA; Trafton, JA, 2006)
"Twelve patients with poor pain control or unacceptable side effects during treatment with morphine were switched to methadone and followed for nine months in this open prospective study."3.73Opioid switching from oral slow release morphine to oral methadone may improve pain control in chronic non-malignant pain: a nine-month follow-up study. ( Borchgrevink, PC; Dale, O; Fredheim, OM; Kaasa, S; Klepstad, P; Landrø, NI, 2006)
"Although studies on the beliefs of persons with chronic nonmalignant pain (CNMP) are still scarce, methadone is increasingly prescribed for the treatment of CNMP."3.73Response phases in methadone treatment for chronic nonmalignant pain. ( Arnaert, A; Ciccotosto, G, 2006)
"We studied the effects of the commonly used mu-opioid receptor agonists morphine, oxycodone, methadone and the enantiomers of methadone in thermal and mechanical models of acute pain and in the spinal nerve ligation model of neuropathic pain in rats."3.73Morphine, oxycodone, methadone and its enantiomers in different models of nociception in the rat. ( Kalso, E; Kontinen, VK; Kylänlahti, I; Lemberg, K; Viljakka, K; Yli-Kauhaluoma, J, 2006)
"Racemic methadone is increasingly used to manage cancer pain."3.73Pharmacokinetics and pharmacodynamics of methadone enantiomers in hospice patients with cancer pain. ( Auret, K; Boyd, F; Ilett, KF; Oh, TE; Page-Sharp, M; Roger Goucke, C, 2006)
"Methadone hydrochloride is an effective, inexpensive, and relatively safe opioid to use in the treatment of patients with chronic pain."3.73Prescribing methadone for pain management in end-of-life care. ( Manfredonia, JF, 2005)
"Methadone has been used as an alternative strong opioid to morphine in the management of cancer pain."3.72An ad libitum schedule for conversion of morphine to methadone in advanced cancer patients: an open uncontrolled prospective study in a Chinese population. ( Ma, HM; Ng, DK; Sham, MM; Tse, DM, 2003)
"To estimate the prevalence and to examine the characteristics of chronic severe pain in chemically dependent populations receiving methadone maintenance or inpatient residential treatment."3.72Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities. ( Cleland, C; Fong, C; Joseph, H; Kipnis, S; Portenoy, RK; Rosenblum, A, 2003)
"To investigate the relationship between the daily dose of the synthetic opioid methadone and the corrected QT (QTc) interval in a series of methadone-treated patients who developed torsade de pointes."3.72Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes. ( Krantz, MJ; Kutinsky, IB; Mehler, PS; Robertson, AD, 2003)
"The objectives of this medico-legal case report were the following: 1) To present an example of a medico-legal problem that developed as a result of a decision to rotate a chronic pain patient (CPP) to methadone in order to taper the CPP from oxycodone; 2) To present both the plaintiff's and defendant's expert witnesses' opinions as to if and where the care of that patient fell below the "standard of medical care;" and 3) Based on these opinions, to develop some recommendations on how, in the future, pain medicine physicians and other physicians should proceed, in order to avoid allegations of breach of "standards of care" when using methadone."3.72Medico-legal rounds: medico-legal issues and alleged breaches of "standards of medical care" in opioid rotation to methadone: a case report. ( Cole, B; Cutler, RB; Fishbain, DA; Lewis, J; Rosomoff, HL; Rosomoff, RS, 2003)
"To assess the outcomes of infants born to mothers receiving methadone for the management of pain in pregnancy."3.72Outcomes of infants born to mothers receiving methadone for pain management in pregnancy. ( Kuschel, C; Sharpe, C, 2004)
"Recent studies indicate that severe chronic pain is common among patients in methadone maintenance treatment (MMT), but no qualitative studies have examined such patients' experiences of pain and pain treatment."3.72The experience of chronic severe pain in patients undergoing methadone maintenance treatment. ( Arnstein, J; Arnsten, JH; Berg, K; Gourevitch, M; Karasz, A; Selwyn, P; Zallman, L, 2004)
"We describe an opioid-tolerant patient with severe acute pain which was unrelieved by morphine and ketamine via intravenous patient-controlled analgesia, but almost totally relieved by methadone."3.71Successful use of oral methadone after failure of intravenous morphine and ketamine. ( Mitchell, SJ; Sartain, JB, 2002)
"To evaluate a series of methadone-treated patients experiencing torsade de pointes."3.71Torsade de pointes associated with very-high-dose methadone. ( Hays, H; Krantz, MJ; Lewkowiez, L; Mehler, PS; Robertson, AD; Woodroffe, MA, 2002)
"An expert working group of the European Association for Palliative Care has revised and updated its guidelines on the use of morphine in the management of cancer pain."3.71Morphine and alternative opioids in cancer pain: the EAPC recommendations. ( Casas, JR; Cherny, N; Conno, F; Hanks, GW; Hanna, M; Kalso, E; McQuay, HJ; Mercadante, S; Meynadier, J; Poulain, P; Radbruch, L; Ripamonti, C; Sawe, J; Twycross, RG; Ventafridda, V, 2001)
"Methadone is still regarded as a second line opioid for patients suffering from severe pain, and is rarely used in hospitalized patients."3.71Methadone is safe for treating hospitalized patients with severe pain. ( Davidson, EM; Rosen, G; Shir, Y; Zeldin, A, 2001)
"The practice included 61 patients who received pain medication through implanted intrathecal catheter pumps, 19 of whom were treated with morphine, either alone or in combination with other medications."3.71Neurologic complications including paralysis after a medication error involving implanted intrathecal catheters. ( Craig, AS; Feler, CA; Jones, TF; Melton, K; Moore, WL; Schaffner, W; Simmons, BP; Smith, MD, 2002)
"In a patient on methadone maintenance treatment, admitted for lung cancer suspicion, a slight decrease in pain dose response to morphine have necessitated adjustments of methadone treatment founded on clinical check-up and methadone assay."3.71Slow metabolism and long half life of methadone in a patient with lung cancer and cirrhosis. ( Beauverie, P; Edel, YA; Furlan, V, 2001)
"Current equianalgesic reference tables, based largely on single dose studies, give dose ratios of 1:1 to 4:1 for oral morphine to oral methadone, which possibly are inaccurate in patients with cancer pain who are exposed to multiple doses of these opioids."3.70Dose ratio between morphine and methadone in patients with cancer pain: a retrospective study. ( Bruera, ED; Hanson, J; Lawlor, PG; Turner, KS, 1998)
"Oral methadone is considered to be a valid opioid analgesic alternative to morphine and hydromorphone in treating cancer pain."3.70Equianalgesic dose/ratio between methadone and other opioid agonists in cancer pain: comparison of two clinical experiences. ( Belzile, M; Bruera, E; De Conno, F; Groff, L; Hanson, J; Pereira, J; Ripamonti, C, 1998)
"To define the dose ratio between morphine and methadone in relation to the previous morphine dose and the number of days needed to achieve the same level of analgesia in a group of patients with advanced cancer with pain who switched from morphine to oral methadone."3.70Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio? ( Brunelli, C; De Conno, F; Groff, L; Polastri, D; Ripamonti, C; Stavrakis, A, 1998)
" In the past 2 years, oral methadone has been used extensively in our institution for treating children with persistent pain from cancer, burns, or trauma who were capable of oral intake and whose pain was not relieved by nonopioid medications."3.70Oral methadone for the treatment of severe pain in hospitalized children: a report of five cases. ( Davidson, EM; Rosen, G; Shavelson, V; Shenkman, Z; Shir, Y, 1998)
"Chronic pain patients who have limited access to opioids may be redirected to methadone maintenance centers for management of their pain."3.70Characteristics of methadone maintenance patients with chronic pain. ( Jamison, RN; Katz, NP; Kauffman, J, 2000)
"Hyperalgesia and allodynia in 4 cancer patients treated with morphine disappeared after discontinuing or substituting morphine with other opioid agonists."3.69Disappearance of morphine-induced hyperalgesia after discontinuing or substituting morphine with other opioid agonists. ( Jensen, NH; Jensen, TS; Sjøgren, P, 1994)
"We evaluated the analgesia, tolerability and absorption profile of methadone hydrochloride in six opioid-naive cancer patients with pain."3.69Rectal methadone in cancer patients with pain. A preliminary clinical and pharmacokinetic study. ( Brunelli, C; De Conno, F; Lodi, F; Ripamonti, C; Rizzio, E; Saita, L; Zecca, E, 1995)
"Five patients with chronic nonmalignant pain were transferred from other analgesics to oral methadone."3.69Oral methadone for managing chronic nonmalignant pain. ( Gardner-Nix, JS, 1996)
"The aims of this study were to describe the analgesia, side effects, and dosage and the causes of suspension of treatment in a large sample of advanced cancer patients with pain after treatment with oral methadone from 7 to 90 days."3.69Clinical experience with oral methadone administration in the treatment of pain in 196 advanced cancer patients. ( Brunelli, C; De Conno, F; Groff, L; Ripamonti, C; Ventafridda, V; Zecca, E, 1996)
"Methadone is a very effective second-line opioid for treatment of cancer pain."3.69Intravenous methadone for cancer pain unrelieved by morphine and hydromorphone: clinical observations. ( Borsook, D; Chandler, SW; Manfredi, PL; Payne, R, 1997)
"Determination of methadone (MET) in biological fluids can serve to adjust dosages in patients suffering from cancer pain or participating in methadone maintenance programs."3.68Rapid determination of methadone in plasma, cerebrospinal fluid, and urine by gas chromatography and its application to routine drug monitoring. ( Brune, K; Geisslinger, G; Schmidt, N; Sittl, R, 1993)
"We report a case of high-dose methadone prescribed to a heroin addict for pain control."3.68High-dose methadone and the need for drug measurements in plasma. ( Hay, A; Raistrick, D; Wolff, K, 1991)
"Concentrations of methadone in plasma, estimates of pain relief, and pupillary size were determined after a single intravenous dose (10 to 30 mg) of methadone hydrochloride to eight patients with chronic pain, five of whom had cancer."3.67Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain. ( Colburn, WA; Foley, KM; Houde, RW; Inturrisi, CE; Kaiko, RF, 1987)
"Dipipanone hydrochloride raised the threshold to ischaemic pain in healthy human volunteers."3.63Analgesic activity of dipipanone hydrochloride in student volunteers. ( CAHAL, DA, 1957)
"Pain, drug cravings, and opioid withdrawal symptoms can interfere with substance use disorder or opioid tapering treatment goals."3.11Hyperbaric Oxygen Therapy for Pain, Opioid Withdrawal, and Related Symptoms: A Pilot Randomized Controlled Trial. ( Bindler, RJ; Layton, ME; Quock, RM; Stanek, K; Wilson, M, 2022)
"Pain was not found to be different between the treatment arms."2.94A single-institution, randomized, pilot study evaluating the efficacy of gabapentin and methadone for patients undergoing chemoradiation for head and neck squamous cell cancer. ( Attwood, K; Bourgeois, DJ; Hermann, GM; Iovoli, AJ; Miller, A; Platek, AJ; Singh, AK; Wang, C, 2020)
"To evaluate the antinociceptive effects of intravenous methadone combined with detomidine or acepromazine in adult horses."2.82Antinociceptive effects of methadone combined with detomidine or acepromazine in horses. ( Crosignani, N; Lopes, C; Luna, SP; Pantoja, JC; Puoli, JN; Quarterone, C; Rosa, AC; Taylor, PM, 2016)
"Forty-two cancer patients with pain and/or opioid side effects were assessed in this randomised trial."2.77Serum concentrations of opioids when comparing two switching strategies to methadone for cancer pain. ( Dale, O; Kaasa, S; Moksnes, K; Paulsen, Ø; Rosland, JH; Spigset, O, 2012)
"Methadone was administered via IV (0."2.76Plasma concentrations and behavioral, antinociceptive, and physiologic effects of methadone after intravenous and oral transmucosal administration in cats. ( Aguiar, AJ; Ferreira, TH; Hudachek, SF; Mama, KR; Rezende, ML, 2011)
"Providing pain management for known opioid abusers is a challenging clinical task, in part because little is known about their pain experience and analgesic requirements."2.69Pain responses in methadone-maintained opioid abusers. ( Charuvastra, VC; Compton, P; Kintaudi, K; Ling, W, 2000)
" The pharmacokinetic parameters of the R- and S-enantiomers of the racemate are reported."2.68Stereoselective pharmacokinetics of methadone in chronic pain patients. ( Angelo, HR; Blemmer, T; Christrup, LL; Drenck, NE; Kristensen, K; Rasmussen, SN; Sjøgren, P, 1996)
"Methadone is a very potent analgesic drug."2.68Pain perception of intravenous heroin users on maintenance therapy with levomethadone. ( Gastpar, M; Katta, T; Klöppel, A; Pries, E; Schall, U, 1996)
" After achieving adequate analgesia with regular dosing of oral methadone (T1), patient-controlled analgesia with methadone was administered for 3 days (T2)."2.68Opioid-sparing effect of diclofenac in cancer pain. ( Barresi, L; Caligara, M; Dardanoni, G; Mercadante, S; Sapio, M; Serretta, R, 1997)
"01) dipipanone and a dose-response relationship was evident."2.66Effects of an opiate on cold-induced pain and the CNS in healthy volunteers. ( Crowley, D; Peck, AW; Phillipson, R; Posner, J; Telekes, A, 1985)
"Methadone is a synthetic opioid analgesic with potential advantages over other commonly used opioids."2.53Methadone analgesia in the critically ill. ( Elefritz, JL; Lyaker, MR; Murphy, CV; Papadimos, TJ, 2016)
"Up to 44% of patients with cancer-related pain require opioid rotation (OR) because of inadequate analgesia or side effects."2.52Methods of Rotation From Another Strong Opioid to Methadone for the Management of Cancer Pain: A Systematic Review of the Available Evidence. ( McLean, S; Twomey, F, 2015)
"Older patients represent a challenge for physicians, as a further factor may play a role in dosing methadone and possibly on successful switching."2.48The effect of age on opioid switching to methadone: a systematic review. ( Bruera, E; Mercadante, S, 2012)
"Methadone was used subcutaneously as an analgesic agent in 1 patient."2.47Review of cancer pain management in patients receiving maintenance methadone therapy. ( McLean, S; McQuillan, R; O'Gorman, A; Rowley, D; Ryan, K, 2011)
"Methadone is an opioid analgesic that is also commonly used to prevent opioid-withdrawal symptoms in patients undergoing treatment for opioid addiction."2.47Methadone: marvelous, malevolent, or merely misunderstood? ( Martin, CM, 2011)
"Pharmacological approaches incorporate the continuation of usual medications (or equivalent), short-term use of sometimes much higher than average doses of additional opioid, and prescription of non-opioid and adjuvant drugs, aiming to improve pain relief and attenuate opioid tolerance and/or opioid-induced hyperalgesia."2.47Acute pain management in opioid-tolerant patients: a growing challenge. ( Huxtable, CA; MacIntyre, PE; Roberts, LJ; Somogyi, AA, 2011)
"Methadone also has a long elimination half-life (19 [SD 14] hours) and NMDA receptor activity although dose administration is complicated by highly variable morphine equianalgesic equivalence (1 : 2."2.45Pediatric palliative care: use of opioids for the management of pain. ( Anderson, BJ; Craig, F; Michel, E; Zernikow, B, 2009)
"Methadone is a long-acting synthetic opioid with high affinity for various opioid receptors, especially for m-opioid receptors."2.45[Methadone treatment and its dangers]. ( Jodziūniene, L; Lazauskas, R; Reingardiene, D, 2009)
"Up to 80% of people with cancer experience pain at some time during their illness, and most will need opioid analgesics."2.44Opioids in people with cancer-related pain. ( Quigley, C, 2008)
" This article reviews the World Health Organization recommendations for analgesic therapy in this setting, as well as guidelines for opioid therapy in patients with renal failure or hepatic failure, assessment of pain, dosing strategies in both acute and chronic pain, management of opioid overdose, pain associated with dose-limiting side effects, and pain in the actively dying."2.44Practical guide to opioids and their complications in managing cancer pain. What oncologists need to know. ( Davis, MP; Gamier, P; Lasheen, W, 2007)
"Pain is a multidimensional symptom that can overshadow all other experiences of both the child and family."2.44The management of pain in children with life-limiting illnesses. ( Friedrichsdorf, SJ; Kang, TI, 2007)
"Methadone is a synthetic opioid with potent analgesic effects."2.43Methadone treatment for pain states. ( Kral, LA; Toombs, JD, 2005)
"Undertreatment of acute pain is suboptimal medical treatment, and patients receiving long-term OAT are at particular risk."2.43Acute pain management for patients receiving maintenance methadone or buprenorphine therapy. ( Alford, DP; Compton, P; Samet, JH, 2006)
"Ongoing assessment, multiple approaches, and excellent communication among all care management team members are critical."2.43Difficult cases in pain management: use of methadone in a multifactorial approach. ( Coyle, N; Coyne, P; Griffie, J, 2006)
"Methadone is a unique mu opioid agonist, which also has delta receptor affinity and properties of N-methyl-D-aspartate receptor antagonism and monoamine reuptake inhibition."2.43Methadone for treatment of cancer pain. ( Bryson, J; Seccareccia, D; Tamber, A; Zimmermann, C, 2006)
" Regular pain assessments combined with appropriate analgesic administration at regular dosing intervals, adjunctive drug therapy for control of adverse effects and associated symptoms, and nonpharmacological interventions are recommended."2.42Cancer pain management in children. ( Mercadante, S, 2004)
"Methadone is a synthetic opioid, with mu and delta receptor activity, associated with the capacity to inhibit N-methyl-D-aspartate receptors."2.41Opioid switch to oral methadone in cancer pain. ( Body, JJ; Lossignol, DA; Mancini, I, 2000)
" When initiating treatment, controlled-release preparations of opioids are generally favoured, and are combined with immediate release morphine to prevent or treat 'breakthrough' pain and to enable the optimum opioid dosage to be calculated."2.41[Treatment of pain in cancer with systemically administered opioids]. ( de Wit, R; Enting, RH; Lieverse, PJ; Smitt, PA; van der Rijt, CC; Wilms, EB, 2001)
"Tramadol is a centrally acting analgesic drug; it has an agonist effect on mu 1 receptors of opioids and acts also by inhibiting the re-uptake of noradrenaline and serotonine which activates descending monoaminergic inhibitory pathways."2.40[Treatment of pain in oncology]. ( De Conno, F; Polastri, D, 1997)
"When pain is relieved inadequately by opioid analgesics given in a dose that causes intolerable side effects despite routine measures to control them, treatment with the same opioid by an alternative route or with an alternative opioid administered by the same route should be considered."2.40Opioid rotation for cancer pain: rationale and clinical aspects. ( Mercadante, S, 1999)
"Gabapentin exposure in treatment-seeking persons with OUD appears to be quite common, and use, both medically and nonmedically, frequently occurs alongside OAMs."1.91Understanding motivations and use typologies of gabapentin with opioid agonist medications. ( Buttram, ME; Ellis, MS; Qureshi, R, 2023)
"Methadone is an effective analgesic with unique pharmacokinetic and pharmacodynamic variables."1.91Comparing National Methadone Equianalgesic Tools. ( Atayee, RS; Edmonds, KP; Wen, RY, 2023)
", i) the analgesic agent is identical to the OAT medication, and ii) the opioid agent is dosed above 1/6th morphine equivalent dose of the OAT medication."1.91Rescue Analgesia for Opioid-Dependent Individuals on Opioid Agonist Treatment during Hospitalization: Adherence to Guideline Treatment. ( Arnet, I; Dürsteler, KM; Grossmann, F; Hersberger, KE; Jaiteh, C, 2023)
" We aimed to assess the immediate effects of the methadone reformulation on missed doses, days off methadone, changes in medication dosing and dispensations of opioids for pain, and hospitalizations and mortality among all people receiving treatment at or near the time of the change."1.72The effect of a methadone reformulation on opioid agonist treatment outcomes: A population-based study in British Columbia, Canada, 2013-14. ( Dale, LM; Hongdilokkul, N; Krebs, E; Min, JE; Nosyk, B; Schnepel, KT; Shigeoka, H, 2022)
"Methadone is a long-acting analgesic that targets the N-methyl-D-aspartate (NMDA) receptor in addition to the mu opioid receptor and has benefit in adult burn patients."1.72Intraoperative Methadone Use in Pediatric Burn Patients. ( Ambardekar, A; Carlson, A; Iskander, I; Pham, D; Price, C; Reisch, J, 2022)
"Buprenorphine was initiated by 58% and 42% started methadone."1.72Factors associated with retention on medications for opioid use disorder among a cohort of adults seeking treatment in the community. ( Biondi, BE; Schlossberg, EF; Shaw, A; Springer, SA; Vander Wyk, B, 2022)
"Methadone doses were changed according to the clinical needs to obtain the most favorable balance between analgesia and adverse effects."1.72Methadone as First-line Opioid for the Management of Cancer Pain. ( Adile, C; Bonanno, G; Casuccio, A; Ferrera, P; Mercadante, S; Pallotti, MC; Ricci, M, 2022)
"Standard of care for opioid use disorder (OUD) includes medication and counseling."1.62A Virtual Reality Meditative Intervention Modulates Pain and the Pain Neuromatrix in Patients with Opioid Use Disorder. ( Bluth, MH; Faraj, MM; Goldberg, E; Greenwald, MK; Lipanski, NM; Marusak, HA; Morales, A, 2021)
"Methadone 45 mg per day was effective in alleviating his pain, but he experienced severe drowsiness following trabectedin induced liver injury."1.51[A Case of Methadone Induced Drowsiness Following Trabectedin Induced Liver Injury]. ( Higuchi, M; Ishiki, H; Kiuchi, D; Satomi, E; Shimizu, M, 2019)
"Treating patients with opioid use disorder (OUD) and traumatic brain injury illustrates 6 neurobiological principles about the actions of 2 contrasting opioid analgesics, morphine and fentanyl, as well as pharmacotherapies for OUD, methadone, naltrexone, and buprenorphine."1.48Neurobiology of Opioid Use Disorder and Comorbid Traumatic Brain Injury. ( Graham, DP; Kosten, TR; Nielsen, DA, 2018)
"In methadone-treated OD subjects drawn from a case and control sample, we conducted a genome-wide association study of usual daily methadone dose."1.46Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1. ( Cook-Sather, SD; Farrer, LA; Gelernter, J; Hakonarson, H; Jensen, KP; Kranzler, HR; Li, J; Nunez, Y; Smith, AH, 2017)
"The aim of the study was to evaluate the tolerability, sedative and analgesic effects of methadone in combination with medetomidine for premedication prior to neutering in healthy cats."1.42Methadone in combination with medetomidine as premedication prior to ovariohysterectomy and castration in the cat. ( Bortolami, E; Murrell, JC; Slingsby, LS, 2015)
"While opioid dependence is a complex health condition, the treatment of HIV-infected individuals with opioid dependence presents additional challenges."1.42HIV-gp120 and physical dependence to buprenorphine. ( Abood, ME; Benamar, K; Palma, J, 2015)
"In methadone treated cats there was no significant variation in MNT over time, suggesting a possible anti-hyperalgesic action, whereas in the other two groups lower thresholds were recorded at various time points after surgery compared to baseline."1.39Methadone in combination with acepromazine as premedication prior to neutering in the cat. ( Bortolami, E; Murrell, JC; Slingsby, LS, 2013)
" Here, we examined whether moderate doses of methadone carry any benefits over chronic use of equianalgesic morphine, the prototypical opioid."1.38Chronic methadone treatment shows a better cost/benefit ratio than chronic morphine in mice. ( Enquist, J; Ferwerda, M; Milan-Lobo, L; Whistler, JL, 2012)
"The methadone was obtained by illegal diversion (sale, gift, or theft) in 67% of cases."1.37The methadone epidemic: methadone-related deaths on the rise in Vermont. ( Madden, ME; Shapiro, SL, 2011)
" In the switching study DDD indicated a reduction in analgesic dosing and OMEQ an increase when switching from WHO step II to III."1.37Choosing the unit of measurement counts: the use of oral morphine equivalents in studies of opioid consumption is a useful addition to defined daily doses. ( Borchgrevink, P; Dale, O; Fredheim, O; Hamunen, K; Mellbye, A; Svendsen, K, 2011)
"Buprenorphine thus appears to be a more effective analgesic than methadone in the presence of gp120 in the brain, a condition that is associated with HIV-related pain and infection."1.37Differential antinociceptive effects of buprenorphine and methadone in the presence of HIV-gp120. ( Adler, MW; Benamar, K; Cowan, A; Geller, EB; Palma, J, 2011)
"Since this operation a recurrence of the displacement has not been observed and consecutively the filling of the pump could be accomplished without radiological investigations."1.36[Displaced pain pump because of a pendulous abdomen - dermatolipectomy as solution of the problem]. ( Föhn, M; Oehy, K; Vetter, M; Wedler, V, 2010)
"Injection users are at risk for vascular injuries resulting in chronic venous disease (CVD)."1.36Injection-related venous disease and walking mobility. ( Birk, TJ; Kirsner, RS; Pieper, B; Templin, TN, 2010)
"Pain is an important and often under-treated symptom of life-threatening illness."1.35[Analgesics and palliative care]. ( Mathieu, N; Tuna, T, 2008)
"This is a case report of a CPP treated by a pain physician."1.35Alleged breaches of "standards of medical care" in a patient overdose death possibly related to chronic opioid analgesic therapy, application of the controlled substances model guidelines: case report. ( Cole, B; Fishbain, DA; Gao, J; Lewis, JE; Rosomoff, RS, 2009)
"7), which approximates the bioavailability of the drug administered orally."1.35Conversion from parenteral to oral methadone. ( Gómez-Batiste, X; González-Barboteo, J; Porta-Sales, J; Sánchez, D; Tuca, A, 2008)
"Cancer pain is common, occurring in up to 60% of patients and opioid conversion may be required for effective pain management."1.35Inconsistencies in opioid equianalgesic ratios: clinical and research implications. ( Kutner, JS; Linnebur, SA; O'Bryant, CL; Yamashita, TE, 2008)
"Methadone was used (71."1.35Prescription opioid use, misuse, and diversion among street drug users in New York City. ( Davis, WR; Johnson, BD, 2008)
"Methadone is an interesting analgesic for multiple reasons."1.35The safety of methadone hydrochloride. ( Swegle, JM; Wensel, DD, 2008)
"The challenge is not in treating pain, but identifying true pain from drug-seeking behaviors."1.35Chronic pain in patients with substance abuse disorder: general guidelines and an approach to treatment. ( Dewey, CM; Mitchell, AM, 2008)
"Neuropathic pain is associated with several sensory abnormalities, including allodynia as well as spontaneous pain."1.34Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. ( Buechler, NL; Eisenach, JC; Kim, SA; Martin, TJ; Porreca, F, 2007)
" In addition, methadone dosage requirements were not influenced by CYP2D6 genotypes in these subjects."1.34Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)- and racemic-methadone. ( Christrup, L; Coller, JK; Foster, DJ; Gillis, D; James, H; Joergensen, C; Somogyi, AA, 2007)
"(1) Methadone is an opiate used for replacement therapy of opiate addiction that causes dose-dependent QT prolongation."1.33Torsades de pointes with methadone. ( , 2005)
"Methadone daily dosage was also analyzed during this study."1.32Methadone and the hospice patient: prescribing trends in the home-care setting. ( Alt, CJ; Gallagher, R; Knowlton, CH; McMath, JA; Weschules, DJ, 2003)
"Pain was associated with an increased propensity for misuse of substances with analgesic effects, suggesting that ongoing pain contributes to an altered and more severe pattern of drug-seeking behavior."1.32Treatment needs associated with pain in substance use disorder patients: implications for concurrent treatment. ( Horst, DA; Humphreys, K; Minkel, JD; Oliva, EM; Trafton, JA, 2004)
"In patients with a history of substance abuse, these are often serious developments to which a clinician must know how to react."1.32Opioid therapy in patients with a history of substance abuse. ( Kirsh, KL; Passik, SD, 2004)
"Methadone is a widely used synthetic opioid which is administered as a racemic mixture of (R)-(--)- and (S)-(+)-enantiomers, with only (R)-(--)-methadone possessing mu opioid receptor agonist activity."1.32(S)-(+)-methadone is more immunosuppressive than the potent analgesic (R)-(--)-methadone. ( Hutchinson, MR; Somogyi, AA, 2004)
"Methadone has been reported to improve pain relief in patients with morphine resistance, and it is lipophilic and exerts a lesser activity on opioid receptors in the gastrointestinal tract."1.31Methadone in treatment of tenesmus not responding to morphine escalation. ( Dabbene, M; Fulfaro, F; Mercadante, S, 2001)
"To assess the effect of opioid substitution (substituting one member of the opioid class for another) on the incidence and severity of adverse effects in palliative care patients who experience unacceptable, refractory adverse effects when taking an opioid drug."1.30Opioid substitution to reduce adverse effects in cancer pain management. ( Ashby, MA; Jackson, KA; Martin, P, 1999)
"Methadone dose was significantly higher in patients who had lower preswitching doses of morphine and vice versa."1.30Rapid switching from morphine to methadone in cancer patients with poor response to morphine. ( Calderone, L; Casuccio, A; Mercadante, S, 1999)
"Twenty patients with end-stage head and neck cancer, unresponsive to either acetaminophen with codeine or oxycodone hydrochloride, were placed on a four-drug analgesic regimen consisting of methadone hydrochloride, Trilisate or acetaminophen, a tricyclic antidepressant, and, in most cases, hydroxyzine."1.29A four-drug pain regimen for head and neck cancers. ( Carrol, EN; Fine, E; Ruff, RL; Stepnick, D, 1994)
"Methadone is a synthetic opioid with excellent oral bioavailability, variable, but long duration of action and extremely low cost."1.29Respiratory depression in a patient receiving oral methadone for cancer pain. ( Bruera, E; Hunt, G, 1995)
" Drug intervention should be on a regular schedule--avoid prn dosage of pain medications."1.27Dilemmas in managing prostate carcinoma (Part II): Metastatic disease. ( Ahmann, FR, 1985)
"Morphine and methadone were found to produce both quantal and graded effects in all experiments."1.27The graded and quantal nature of opioid analgesia in the rat tailflick assay. ( Cohen, A; Inturrisi, CE; Ling, GS; Umans, JG; Yoburn, BC, 1985)
"If pain is in the trigeminal nerve distribution, local nerve block procedures may provide additional relief."1.26Pain control in advanced and recurrent head and neck cancer. ( McCann, CF; Scott, RM; Shapshay, SM; Stoelting, I, 1980)
" Long-term use of analgesic drugs in chronic pain usually produces negative behavioral complications that are more difficult to manage than the pain it was desired to eliminate."1.26Analgesic drugs in the management of pain. ( Halpern, LM, 1977)
" Evidence of tolerance was indicated by the fact that when the antinociceptive response to morphine was assessed by the hot-plate and the tail-flick procedures, a shift in the dose-response curve of morphine to the right occurred after an adequate single priming dose of morphine."1.26Studies on tolerance development to single doses of morphine in mice. ( Huidobro, F; Huidobro-Toro, JP; Leong Way, E, 1976)
"Methadone is an effective analgesic whose pharmacokinetics must be appreciated in order for it to be used safely and effectively."1.26Important clinical pharmacologic considerations in the use of methadone in cancer patients. ( Ettinger, DS; Trump, DL; Vitale, PJ, 1979)
"Xylazine was significantly more effective in obtunding deep pain (P less than 0."1.26Objective tests of analgesic drugs in ponies. ( Lumb, WV; Pippi, NL, 1979)
" Unit dose packaging is used because the oral solid dosage forms (including placebos) are made to look alike."1.25Drug use and distribution in a pain rehabilitation center. ( Beckner, TF; Idsvoog, P, 1975)

Research

Studies (480)

TimeframeStudies, this research(%)All Research%
pre-199084 (17.50)18.7374
1990's47 (9.79)18.2507
2000's183 (38.13)29.6817
2010's130 (27.08)24.3611
2020's36 (7.50)2.80

Authors

AuthorsStudies
Galt, RH1
Horbury, J1
Matusiak, ZS1
Pearce, RJ1
Shaw, JS1
Dufort, A1
Samaan, Z1
Komrowski, MD1
Sekhri, NK1
Treillet, E1
Giet, O1
Picard, S1
Laurent, S1
Seresse, L1
Krebs, E1
Hongdilokkul, N1
Dale, LM1
Min, JE1
Schnepel, KT1
Shigeoka, H1
Nosyk, B1
Ozberk, D1
Haywood, A3
Sutherland, HG1
Yu, C1
Albury, CL1
Zunk, M1
George, R2
Good, P3
Griffiths, LR1
Hardy, J3
Haupt, LM1
Carlson, A1
Pham, D1
Price, C1
Reisch, J1
Iskander, I1
Ambardekar, A1
Biondi, BE1
Vander Wyk, B1
Schlossberg, EF1
Shaw, A1
Springer, SA1
Mercadante, S24
Adile, C5
Ferrera, P7
Pallotti, MC1
Ricci, M1
Bonanno, G1
Casuccio, A9
Wilson, M1
Bindler, RJ1
Stanek, K1
Layton, ME1
Quock, RM1
Wallen, TE1
Elson, NC1
Singer, KE1
Hayes, HV1
Salvator, A1
Droege, CA1
Nomellini, V1
Pritts, TA1
Goodman, MD1
Haas, MF1
Latchman, J1
Guastella, AM1
Craig, DS1
Chang, YD1
Esposito, DB1
Huybrechts, KF2
Werler, MM1
Straub, L1
Hernández-Díaz, S2
Mogun, H2
Bateman, BT2
Ellis, MS3
Qureshi, R3
Buttram, ME3
Grassi, Y1
Cascio, AL2
Thakrar, AP1
Uritsky, TJ1
Christopher, C1
Winston, A1
Ronning, K1
Sigueza, AL1
Caputo, A1
McFadden, R1
Olenik, JM1
Perrone, J1
Delgado, MK1
Lowenstein, M1
Compton, P4
Wen, RY1
Edmonds, KP2
Atayee, RS3
Reynolds-Wright, JJ1
Morroni, C1
Woldetsadik, MA1
Cameron, ST1
Wong, ML1
Achu, RA1
Spence, NZ1
White, KO1
Hughto, JMW1
Tapper, A1
Rapisarda, SS1
Stopka, TJ1
Palacios, WR1
Case, P1
Silcox, J1
Moyo, P1
Green, TC1
Arnet, I1
Dürsteler, KM1
Jaiteh, C1
Grossmann, F1
Hersberger, KE1
Pan, S1
Anderson, TA1
Ledlie, S1
Tadrous, M1
McCormack, D1
Campbell, T1
Leece, P1
Kleinman, RA1
Kolla, G1
Besharah, J1
Smoke, A1
Sproule, B2
Gomes, T1
De Aquino, JP1
Meyerovich, J1
Xie, CZ1
Ranganathan, M1
Pittman, B1
Rogan, M1
Sofuoglu, M1
Kerr, CL1
Swanton, WE1
Makunts, T1
U, A1
Abagyan, R1
Smith, MA1
Quirk, KC1
Saul, DC1
Rodgers, PE1
Silveira, MJ1
Hermann, GM1
Iovoli, AJ1
Platek, AJ1
Wang, C1
Miller, A1
Attwood, K1
Bourgeois, DJ1
Singh, AK1
McPherson, ML3
Wendling, AL1
Garvan, C1
Roussos-Ross, D1
Zhang, L1
Zeng, D1
Morie, KP1
Potenza, MN1
Beitel, M4
Oberleitner, LM1
Roos, CR1
Yip, SW1
Oberleitner, DE1
Gaeta, M1
Barry, DT4
Amon, T1
Kästner, SBR1
Kietzmann, M1
Tünsmeyer, J1
Faraj, MM1
Lipanski, NM1
Morales, A1
Goldberg, E1
Bluth, MH1
Marusak, HA1
Greenwald, MK1
Furst, JA1
Mynarski, NJ1
McCall, KL1
Piper, BJ1
Biewald, MA1
Scarborough, B1
Lindenberger, E1
Faul, M1
Bohm, M1
Alexander, C1
Hoff, AM1
Hartwig, KN1
Rosielle, DA1
Nordmann, S1
Vilotitch, A1
Lions, C1
Michel, L1
Mora, M1
Spire, B2
Maradan, G1
Bendiane, MK1
Morel, A1
Roux, P2
Carrieri, P1
Karimian, P1
Ajayi, TA1
Yang, YJ1
Xu, YM1
Chen, WC1
Zhu, JH1
Lu, J1
Zhong, BL1
Hennig, S1
Khan, S2
Norris, R1
Zhou, K1
Jia, P1
Bhargava, S1
Zhang, Y2
Reza, T1
Peng, YB1
Wang, GG1
Adam, VN1
Matolić, M1
Stojčić, EG1
Mršić, V1
Rašić, Ž1
Cone, K1
Lanpher, J1
Kinens, A1
Richard, P1
Couture, S1
Brackin, R1
Payne, E1
Harrington, K1
Rice, KC2
Stevenson, GW1
Nnoli, A1
Seligman, NS1
Dysart, K1
Baxter, JK1
Ballas, SK1
Kosten, TR3
Graham, DP1
Nielsen, DA1
Costantino, RC1
McPherson, AL1
Voon, P1
Greer, AM1
Amlani, A1
Newman, C1
Burmeister, C1
Buxton, JA1
Goldschmidt, AB1
Cotton, BP1
Mackey, S1
Laurent, J1
Bryson, WC1
Bond, DS1
Gozalo-Marcilla, M1
de Oliveira, AR1
Fonseca, MW1
Possebon, FS1
Pelligand, L1
Taylor, PM3
Luna, SPL1
Walker, KA1
Davis, MP4
Bruera, E20
Reddy, A2
Paice, J1
Malotte, K1
Lockman, DK1
Wellman, C1
Salpeter, S1
Bemben, NM1
Ray, JB1
Lapointe, BJ1
Chou, R1
Chalker, C1
O'Neill, H1
Cranfield, F1
Friedrichsdorf, SJ2
Shimizu, M1
Higuchi, M1
Ishiki, H1
Kiuchi, D1
Satomi, E1
Valle, A1
Agnelotti, C1
Caruselli, A1
Moody, DE1
Latuga, NM1
Wahler, RG1
Abadie, JM1
Nyamathi, A1
Albarrán, CR1
Branson, C1
Marfisee, M1
Khalilifard, F1
Leake, B1
Haroutiunian, S1
Kagan, L1
Yifrach-Damari, I1
Davidson, E1
Ratz, Y1
Hoffman, A1
Breivik, H1
Prestia, G1
Warne, LN1
Beths, T1
Holm, M1
Bauquier, SH1
Hadley, G1
Derry, S2
Moore, RA1
Wiffen, PJ2
Aoki, Y1
Mizoguchi, H1
Watanabe, C1
Sakurada, T1
Sakurada, S1
Love, R1
Bourgeois, K1
Price, LC1
Wobeter, B1
Delate, T1
Kurz, D1
Shanahan, R1
Didwaniya, N1
Gottumukkala, RS1
Connelly, P1
Wu, H1
Fodor, A1
Tímár, J1
Zelena, D1
Afsharimani, B1
Movva, R1
Gregg, M1
Martinez, L1
Samaritan, G1
Staab, C1
Slingsby, LS2
Bortolami, E2
Murrell, JC2
Salpeter, SR1
Buckley, JS1
Buckley, NS1
Palma, J2
Abood, ME1
Benamar, K2
Hawley, P1
Wing, P1
Nayar, S1
McLean, S2
Twomey, F1
Desai, RJ1
Patorno, E1
Kaltenbach, K2
Kerzner, LS1
Lu, Z1
Xu, J1
Rossi, GC1
Majumdar, S1
Pasternak, GW1
Pan, YX1
Cobos, EJ1
Baeyens, JM1
Talebi, S1
Azhir, A1
Zuber, S1
Soman, S1
Visco, F1
Totouom-Tangho, H1
Kalantar, H1
Worku Hassen, G1
Lopes, C1
Luna, SP2
Rosa, AC1
Quarterone, C1
Crosignani, N1
Pantoja, JC1
Puoli, JN1
Linares, OA1
Fudin, J1
Daly, A1
Schiesser, WE1
Boston, RC1
Brennan, F1
Johnson, J1
Sheth, S1
Elefritz, JL2
Murphy, CV2
Papadimos, TJ1
Lyaker, MR2
Zahari, Z1
Lee, CS1
Ibrahim, MA1
Musa, N1
Mohd Yasin, MA1
Lee, YY1
Tan, SC1
Mohamad, N1
Ismail, R1
Jones, CM1
Baldwin, GT1
Manocchio, T1
White, JO1
Mack, KA1
Courtemanche, F1
Dao, D1
Gagné, F1
Tremblay, L1
Néron, A1
Horst, J1
Frei-Jones, M1
Deych, E1
Shannon, W1
Kharasch, ED1
Haumann, J1
Geurts, JW1
van Kuijk, SM1
Kremer, B1
Joosten, EA1
van den Beuken-van Everdingen, MH1
Ruan, X1
Luo, JJ1
Kaye, AD1
Arnold, C1
Dönselmann Im Sande, P1
Hopster, K1
Kästner, S1
Dervan, LA1
Yaghmai, B1
Watson, RS1
Wolf, FM1
Smith, AH1
Jensen, KP1
Li, J1
Nunez, Y1
Farrer, LA1
Hakonarson, H1
Cook-Sather, SD1
Kranzler, HR1
Gelernter, J1
Nicholson, AB4
Watson, GR1
Bond, BS1
Peng, P1
Tumber, P1
Stafford, M1
Gourlay, D2
Wong, P1
Galonski, M1
Evans, D1
Gordon, A1
Hutchinson, MR2
Coats, BD1
Lewis, SS1
Sprunger, DB1
Rezvani, N1
Baker, EM1
Jekich, BM1
Wieseler, JL1
Somogyi, AA6
Martin, D1
Poole, S1
Judd, CM1
Maier, SF1
Watkins, LR1
Prommer, EE1
Gaertner, J3
Voltz, R3
Ostgathe, C3
Hines, S1
Theodorou, S1
Williamson, A1
Fong, D1
Curry, K1
Burgess, FW2
Pawasauskas, J1
BIETER, RN1
HIRSH, SA1
ISHMAEL, WK1
STACY, JR1
Mathieu, N1
Tuna, T1
Fishbain, DA2
Lewis, JE1
Gao, J1
Cole, B2
Rosomoff, RS2
Cone, EJ1
Caplan, YH1
Black, DL1
Robert, T1
Moser, F1
Blondell, RD1
Ashrafioun, L1
González-Barboteo, J1
Porta-Sales, J1
Sánchez, D1
Tuca, A1
Gómez-Batiste, X1
Eisenberg, E1
Leppert, W2
Hay, JL2
White, JM2
Bochner, F2
Semple, TJ1
Rounsefell, B1
Berg, KM2
Arnsten, JH3
Sacajiu, G1
Karasz, A2
Gallagher, R2
Cooperman, NA1
Newville, H1
le Polain de W, B1
Hanlon, JT1
Weiner, DK1
Zernikow, B1
Michel, E1
Craig, F1
Anderson, BJ2
He, L1
Kim, J1
Ou, C1
McFadden, W1
van Rijn, RM1
Whistler, JL2
Villari, P4
Intravaia, G1
Mangione, S1
Peles, E3
Schreiber, S3
Adelson, M3
Cubero, DI1
del Giglio, A1
Andrews, CM1
Krantz, MJ3
Wedam, EF1
Marcuson, MJ1
Capacchione, JF1
Haigney, MC1
Quigley, C1
Fine, PG4
Jones, HE2
O'Grady, K1
Dahne, J1
Johnson, R1
Lemoine, L1
Milio, L1
Ordean, A1
Selby, P2
Reingardiene, D1
Jodziūniene, L1
Lazauskas, R1
Newman, RG1
van Loon, JP1
Stienen, PJ1
Doornenbal, A1
Hellebrekers, LJ1
Garnet, B3
Joshi, D2
Rosenblum, A6
Schottenfeld, RS3
Marceau, JR1
Murray, H1
Nanan, RK1
Elkader, AK1
Brands, B2
Callaghan, R1
Sproule, BA1
McNulty, JP1
Reddy, S3
Hui, D1
El Osta, B2
de la Cruz, M2
Walker, P1
Palmer, JL3
Larson, ME1
Richards, TM1
Parsons, HA1
Li, Z1
Calderon, B1
Modesto-Lowe, V1
Brooks, D1
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Fredheim, OM5
Nøstdahl, T1
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Borchgrevink, PC5
Bean, HK1
Gannon, R1
Vetter, M1
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Wedler, V1
Grant, KJ2
Baca, CT2
Dasgupta, N2
Bailey, EJ1
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Parrino, M2
Dart, RC2
Pollock, AB1
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Morgan, V1
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Hetzroni, T1
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Cutter, CJ2
Hagen, NA2
Moulin, DE2
Brasher, PM1
Biondo, PD1
Eliasziw, M1
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Stiles, CR1
Raehal, KM1
Bohn, LM1
Rowley, D1
O'Gorman, A1
Ryan, K1
McQuillan, R1
Carrieri, MP1
Cohen, J1
Ravaux, I1
Dellamonica, P1
Protopopescu, C1
Arcuri, E1
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Templin, TN1
Kirsner, RS1
Birk, TJ1
Walmsley, R1
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Madden, ME1
Shapiro, SL1
Savant, J1
Peters, S1
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Sylvester, RK1
Schauer, C1
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Folk, JE1
Negus, SS1
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Mellbye, A1
Dale, O5
Krebs, EE1
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Bair, MJ1
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Geller, EB1
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Morgan, RW1
Nicholson, KL1
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Yamashita, TE1
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LeBaron, V1
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Ng, DK1
Ma, HM1
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Fong, C2
Kipnis, S1
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Klein, D1
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Kutinsky, IB1
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FAUCETT, RL2
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MATTS, SG1
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VEATCH, RM1
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VOTAVA, Z1
Drummond, PD1
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Manfredonia, JF1
Swegle, JM1
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Stine, SM1
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Richeimer, S1
Vielvoye-Kerkmeer, AP1
van Mansom, I1
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Glaser, SE1
Hansen, H1
Benyamin, R1
Patel, S1
Manchikanti, L1
Merlo, LJ1
Gold, MS1
Mitchell, AM1
Dewey, CM1
Berger, A1
Blinderman, CD1
Derby, S2
Inturrisi, C2
Kalman, J1
Mehta, D1
Pappagallo, M1
Perlov, E1
Halpern, L1
Tennant, FS1
Kehlet, H1
Madsen, OG1
Christoffersen, I1
Philbert, A1
Paalzow, L2
Andersson, B2
Lööf, G2
Kullman, S1
Snow, AE1
Dewey, WL1
Posner, J4
Powers, DA1
Hamilton, CW1
Roberts, KB1
Kantor, TG1
Cantor, R1
Tom, E1
Sorkin, EM1
Ogawa, GS1
Jaspersen, HP1
Maxwell, MB1
Tung, AS1
Yaksh, TL1
Shapshay, SM1
Scott, RM1
McCann, CF1
Stoelting, I1
Carrol, EN1
Fine, E1
Ruff, RL1
Stepnick, D1
Birmingham, PK1
Hunt, G1
Sjøgren, P2
Jensen, NH1
Jensen, TS1
Morley, JS1
Watt, JW1
Wells, JC1
Miles, JB1
Finnegan, MJ1
Leng, G1
O'Neill, WM1
Onen, TS1
Samuelsson, H1
Ekman, R1
Hedner, T1
Schmidt, N1
Sittl, R1
Brune, K1
Geisslinger, G1
Watanabe, S4
Fainsinger, RL3
Spachynski, K1
Suarez-Almazor, M1
Zecca, E2
Brunelli, C3
Rizzio, E1
Saita, L1
Lodi, F1
De Conno, F5
Gardner-Nix, JS1
Kristensen, K2
Blemmer, T1
Angelo, HR2
Christrup, LL2
Drenck, NE1
Rasmussen, SN1
Pereira, J2
Belzile, M2
Kuehn, N1
Hanson, J3
Groff, L4
Ventafridda, V2
Sapio, M2
Serretta, R2
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Gastpar, M1
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Clausen, TG1
Borsook, D1
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Dardanoni, G1
Barresi, L1
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Fitzgibbon, DR1
Ready, BL1
Lawlor, PG1
Turner, KS1
Bruera, ED1
Makin, MK1
Ellershaw, JE1
Oxenham, D1
Farrer, K1
Stavrakis, A1
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Shavelson, V1
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Rosen, G2
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Gonty, N1
Trotman, IF1
Angst, MS1
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Dyck, JB1
Gagnon, B1
Calderone, L1
Rashiq, S1
Jamison, RN1
Kauffman, J1
Katz, NP1
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Pasero, C1
Charuvastra, VC1
Kintaudi, K1
Ling, W1
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Englberger, W1
Hanks, GW1
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Hanna, M1
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Meynadier, J1
Poulain, P1
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Twycross, RG1
Fulfaro, F2
Dabbene, M1
Walsh, D1
Boffi, R1
Gebbia, V1
Enting, RH1
van der Rijt, CC1
Wilms, EB1
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de Wit, R1
Smitt, PA1
Dickerson, ED2
Byrne, A1
Zeldin, A1
Jones, TF1
Feler, CA1
Simmons, BP1
Melton, K1
Craig, AS1
Moore, WL1
Smith, MD1
Schaffner, W1
Sperber, KT1
Hord, ED1
Beauverie, P1
Furlan, V1
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Kornick, C1
Fischberg, D1
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Kääriäinen, I1
Ahtee, L1
Halpern, LM2
Huidobro, F1
Huidobro-Toro, JP1
Leong Way, E1
Ettinger, DS1
Vitale, PJ1
Trump, DL1
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Lumb, WV1
Walker, L1
Eastman, M1
Cardoni, AA1
Walters, JK1
Haigler, HJ1
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Peck, AW3
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Shapira, Y1
Klin, B1
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Crowley, D1
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Clinical Trials (30)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Descriptive, Prospective Study of the Characteristics of Chronic Pain in Patients With Addiction to at Least One Substance[NCT05976178]300 participants (Anticipated)Observational2022-12-10Recruiting
Investigation of Pharmacokinetics and Pharmacodynamics of Epidural Methadone in Healthy Volunteers[NCT03525509]Early Phase 113 participants (Actual)Interventional2018-06-04Completed
The Effect of Methadone vs. Fentanyl Administration on Postoperative Pain Control in Pediatric Patients Undergoing Cardiac Surgery: A Randomized, Double-Blinded Controlled Trial[NCT02747875]26 participants (Actual)Interventional2016-09-30Terminated (stopped due to Drug Shortage)
Methadone in Pediatric and Adult Sickle Cell Patients[NCT00761085]47 participants (Actual)Interventional2008-01-01Completed
Prospective Randomized Simple Blinded Study Comparing Two Conversion Ratios From Parenteral to Oral Methadone in Patients With Cancer Pain.[NCT01836328]Phase 344 participants (Actual)Interventional2011-08-31Completed
Influence of Aging on Perioperative Methadone Dosing[NCT04526236]Phase 460 participants (Actual)Interventional2019-09-03Completed
Randomized Double-blind Controlled Study to Assess the Efficacy of Intravenous Acetaminophen Associated With Strong Opioids in the Management of Acute Pain in Adult Cancer Patients[NCT04779567]Phase 4112 participants (Actual)Interventional2019-06-10Completed
Effect of Opioid Taper on Pain Responses in Patients With Chronic Pain[NCT03912298]7 participants (Actual)Observational2019-04-15Completed
The Norwegian Addiction, Pain and Trauma Study[NCT04908410]1,500 participants (Anticipated)Observational2021-03-23Recruiting
Evaluation of the Efficacy and Mechanisms of a Novel Intervention for Chronic Pain Tailored to People Living With HIV[NCT03692611]280 participants (Actual)Interventional2019-08-14Active, not recruiting
Switching From Morphine to Methadone. A Clinical, Pharmacological and Pharmacogenetic Study[NCT00184496]Phase 342 participants (Actual)Interventional2004-08-31Completed
A Double Blind, Randomized Clinical Trial Comparing Postoperative Narcotic Usage in Patients Receiving Periarticular Liposomal Bupivicaine vs. Those Patients Receiving Standard Periarticular Joint Injections[NCT02682498]Phase 438 participants (Actual)Interventional2013-10-31Completed
Role of CYP2B6, CYP3A4, and MDR1 in the Metabolic Clearance of Methadone in Human Subjects[NCT00504413]Phase 120 participants (Anticipated)Interventional2007-07-31Recruiting
An Open-label, Randomised Pilot Study Comparing the Efficacy, Safety and Tolerability of Raltegravir With Protease Inhibitor-based Therapy in Treatment-naïve, HIV/Hepatitis C Co-infected Injecting Drug Users Receiving Methadone[NCT01105611]Phase 440 participants (Anticipated)Interventional2010-08-31Recruiting
Methadone for 'Adenocarcinopathic' Pain Treatment: Methadone vs. Morphine Vanguard RCT[NCT05325164]Phase 30 participants (Actual)Interventional2022-09-30Withdrawn (stopped due to Trial not started; change in Sponsor and Principal Investigator, trial to be registered again by new Sponsor/Investigator if it is started.)
Switching From Morphine to Oral Methadone Plus Acetaminophen in the Treatment of Cancer Pain: A Randomized, Double-Blind Study[NCT00525967]Phase 2/Phase 350 participants (Anticipated)Interventional2006-02-28Recruiting
Pomegranate Juice Consumption by Patients Under Medication for Addiction Treatment as a Regulator of Craving and Blood Redox Status: The Study Protocol of a Randomized Control Trial (the NUTRIDOPE Study)[NCT05861544]58 participants (Anticipated)Interventional2023-03-23Enrolling by invitation
Does Intraoperative Methadone Prevent Postoperative Pain in Bariatric Surgery?[NCT02775474]Phase 432 participants (Actual)Interventional2016-06-30Completed
Evaluating the Use of Sublingual Sufentanil in Patients With Suboxone Treatment Who Are Undergoing Ambulatory Surgery- a Case Series[NCT04716413]Phase 43 participants (Actual)Interventional2021-09-27Terminated (stopped due to Terminated early due to funding, lack of participants)
Single-dose Intraoperative Methadone for Early Ambulation and Sustained Pain Control in Spinal Fusion Surgery Patients[NCT02989597]Phase 410 participants (Actual)Interventional2017-07-29Terminated (stopped due to Due to personnel loss and logistical issues the study was unable to be completed as planned.)
Opioid Switching From Oral Slow Release Morphine to Oral Methadone May Improve Pain Control in Chronic Non-malignant Pain: a Nine-month Follow-up Study.[NCT00356083]Phase 312 participants (Actual)Interventional2004-01-31Completed
Behavioral Intervention to Improve Insomnia Symptoms in Patients With Opioid Use Disorder[NCT05588726]0 participants (Actual)Interventional2022-01-01Withdrawn (stopped due to Staff no longer available to continue enrollment and other research activities)
The Effect of Acute Intravenous Morphine Administration on Sleep Disordered Breathing (SDB) in Patients With Moderate Obstructive Sleep Apnoea (OSA): A Paired Design Trial[NCT03127800]Phase 36 participants (Actual)Interventional2016-05-20Terminated (stopped due to Difficulties with recruitment)
A Randomized Blinded Prospective Trial Comparing Single Intraoperative Dose of Methadone Versus Placebo in Pediatric Patients Undergoing Spine Surgery.[NCT02206685]Phase 474 participants (Actual)Interventional2014-05-31Completed
Development and Evaluation of a Methadone Protocol for Severe Chronic Pain Management[NCT02335398]Phase 434 participants (Actual)Interventional2011-07-31Completed
IRB-HSR# 14145 R,S Methadone: Analgesia and Pharmacokinetics in Adolescents Undergoing Scoliosis Correction[NCT01205256]Phase 311 participants (Actual)Interventional2009-03-31Completed
Study of the Efficiency of the Ketamine With Low Analgesic Doses, in Association With High Opioids, in the Treatment of the Rebels Pains, in Palliative Phase of the Cancerous Disease[NCT01326325]Phase 324 participants (Actual)Interventional2011-07-31Completed
Effect of Beta Blockade on Opioid-Induced Hyperalgesia in Humans[NCT01222091]Phase 210 participants (Actual)Interventional2009-02-28Completed
The Effects of Opioid Taper on Opioid-Induced Hyperalgesia[NCT03063905]15 participants (Actual)Observational2017-01-31Terminated (stopped due to funding expired)
Intraoperative Methadone Versus Morphine for Postoperative Pain Control in Patients Undergoing Intramedullary Nailing or Open Reduction and Internal Fixation of the Tibia[NCT01430182]17 participants (Actual)Interventional2011-09-30Terminated (stopped due to Shortages of study drug, difficulty enrolling patients)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Total Opioid Dose, in Morphine Equivalents, in the First 24 Hours After Pediatric Cardiac Bypass Surgery.

The distribution of the total opioid dose in the first 24 hours will be evaluated by randomization group (methadone vs. fentanyl) and differences between groups will be tested. It is hypothesized that compared to fentanyl, methadone administered intraoperative will result in a significantly lower total opioid dose (morphine or oxycodone) during the first 24 hour postoperative period. Assuming no difference between the two treatment strategies in the population, a total sample size of 52 in each group will provide 80% power to detect an effect size of 0.1. Significance will be measured as a 30% reduction in postoperative pain requirement. (NCT02747875)
Timeframe: 24 hours

Interventionmg postop morphine equivelant 24hr (Mean)
Control - Fentanyl0.55
Treatment - Methadone0.48

Opioid-related Adverse Events Including: Respiratory Failure, Cardiovascular Instability, and Postoperative Nausea and Vomiting

Opioid-related adverse events will be monitored closely and a secondary analysis will compare the incidence of side effects between the two groups during the first 24-hour postoperative period. The Pearson's contingency chi-square test will be used to evaluate any differences between the randomization groups in opioid-related adverse events during the first 24-hour postoperative period. (NCT02747875)
Timeframe: 24 hours

,
Interventionevents (Mean)
Ondansetron DosesEmesis EpisodesHypoventilation EpisodesArrhythmias
Control - Fentanyl3.812.7200
Treatment - Methadone3.432.0800

Pain Relief

Pain relief score using the 10CM VAS, which has a pain scale of 0-10, with 0=no pain and 10=worst pain experienced (NCT00761085)
Timeframe: 72 hr

Interventionunits on a scale (Mean)
Methadone-Children8
Morphine-Children4
Methadone-Adults5
Morphine-Adults5

To Determine the Pharmacokinetics of Methadone in Children and Adults With Sickle Cell Disease Experiencing a VOE.

R-Methadone AUC (NCT00761085)
Timeframe: 96 hr

Intervention(hr*ng/ml) (Mean)
Methadone-Children523
Morphine-Children0
Methadone-Adults637
Morphine-Adults0

Conditioned Pain Modulation Measured Using the Quantitative Sensory Testing (QST)

Conditioned pain modulation will be measured using the quantitative sensory testing (QST) employing procedures consistent with those described in the literature to capture supra-spinal mechanisms of OIH. To detect conditioned modulation, the subject is asked to verbally report the severity of pain experienced on a visual analogue scale (0- no pain, 10-worst pain ever) to a three-second painful heat stimulus (47○C) delivered at 12-15 second intervals, in the presence or absence of the non-dominant limb being immerged in a cold-water bath (12○C). The reported value is the difference between the average of pain scores reported in the absence of vs. the presence of the counter-stimulation. Reported are changes in the conditioned pain modulation assay both prior to and following taper. Taper is individualized thus length of taper varies between subjects. (NCT03912298)
Timeframe: up to one year (individualized, variable taper length)

Interventionunits on a visual analogue scale (Mean)
pre-taper conditioned pain modulation (baseline)post taper conditioned pain modulation (individualized taper, thus time length varies)
Chronic Pain Patients Undergoing Opioid Taper-0.14-0.40

Pain Perception Measured Using the Cold-pressor Test (CPT)

Pain perception will be measured using the cold-pressor test (CPT) employing procedures consistent with those described in the literature. Order of pain testing will vary, and three aspects of the pain response will be captured at each study session: evoked pain; temporal summation; and conditioned pain modulation, which map on to the hypothesized peripheral, spinal and supra-spinal mechanisms of OIH. Reported are cold-pressor pain tolerance prior to and following taper. (NCT03912298)
Timeframe: up to one year (length of taper individualized and varies)

Interventionseconds (Mean)
pre taper pain tolerance (baseline)post-taper pain tolerance (timeframe variable)
Chronic Pain Patients Undergoing Opioid Taper24.0142.02

48 Hour Post-surgical Opioid Use

A comparison of group means between the control group and study group with regards to 48 hour opioid use. (NCT02682498)
Timeframe: 48 hours

Interventionmorphine equivalents (Mean)
EXPAREL® Bupivacaine Liposome Suspension5.32
Standard Periarticular Joint Injection5.07

Average Daily Opioid Use During Admission

Opioid use will be monitored daily from the time of admission in comparison of standard knee injection post-operatively. (NCT02682498)
Timeframe: Up to 48 hours

InterventionTotal Morphine Equivalents (Mean)
EXPAREL® Bupivacaine Liposome Suspension100
Standard Periarticular Joint Injection103

Average Daily Patient Pain Score

Examining the average daily patient pain score in comparison of standard knee injection post-operatively. The measure is the Visual-Analog-Scale (VAS) for subjective pain reporting. The minimum 0 (no pain) and the maximum is 10 (worst pain imagineable). There is only one measure in the scale (i.e. there are no subscales). Lower scores on the VAS scale equate to less pain and are therefore desirable. (NCT02682498)
Timeframe: Up to 48 hours

InterventionVisual Analog Scale Rating (Mean)
EXPAREL® Bupivacaine Liposome Suspension4.75
Standard Periarticular Joint Injection5.75

Post-operative Complications

Examining the post-operative complication in comparison of standard knee injection post-operatively. (NCT02682498)
Timeframe: Up to 1 month

Interventioncomplications (Number)
EXPAREL® Bupivacaine Liposome Suspension0
Standard Periarticular Joint Injection0

Recovery Room Opioid Use

Post anesthesia care unit (recovery room) opioid use in total mg morphine IV equivalent in comparison of standard knee injection post-operatively. (NCT02682498)
Timeframe: Up to 48 hours

InterventionTotal morphine equivalents (Median)
EXPAREL® Bupivacaine Liposome Suspension5
Standard Periarticular Joint Injection5

Opioid Usage

Subjects were given access to Patient-Controlled Intravenous Opioid Administration (PCA) to manage their post-operative pain. The doses of morphine were calculated at at PACU, 24 hours, 48 hours and 72 hours respectively. (NCT02206685)
Timeframe: Admission to PACU to 72 hours post-operative

,
Interventionmg/kg (Median)
PACU24 Hours48 Hours72 Hours
Control Group0.470.550.550.04
Treatment Group0.410.580.580.10

Pain Scores

The FLACC scale or Face, Legs, Activity, Cry, Consolability scale is a measurement used to assess pain for children between the ages of 2 months and 7 years or individuals that are unable to communicate their pain. The scale is scored in a range of 0-10 with 0 representing no pain. The scale has five criteria, which are each assigned a score of 0, 1 or 2. The data reported here represents the mean difference in FLACC score by treatment group at PACU, 24 hours, 48 hours and 72 hours, respectively. (NCT02206685)
Timeframe: Admission to PACU to 72 hours post-operative

,
Interventionunits on a scale (Mean)
PACU24 Hours48 Hours72 Hours
Control Group0.650.420.360.29
Treatment Group0.530.140.240.16

Objective Opioid Withdrawal Scale (OOWS)

OOWS: Is a 13-item instrument of documenting physically observable signs of withdrawal, which are rated as present (1) or absent (0) during the observation period. Maximum score = 13, minimum score = 0. Lower scores correspond to fewer symptoms. (NCT01222091)
Timeframe: Pretreatment [90 min prior to 60-min REM infusion]; 30 min prior to 60-min REM infusion; 15 and 40 min after start of 60-min REM infusion; 5, 15, and 75 minutes after finish of 60-min REM infusion)

,
Interventionunits on a scale (Mean)
Pretreatment30 min prior to REM infusion15 min after start of REM infusion40 min after start of REM infusion5 minutes after finish of REM infusion15 minutes after finish of REM infusion75 minutes after finish of REM infusion
Placebo1.11.10.80.51.82.11.6
Propranolol1.21.10.10.832.81.7

Percent Change From Baseline in Size (Area) of Secondary Hyperalgesia After Cessation of Remifentanil Infusion, a Measure of Opioid-induced Hyperalgesia (OIH).

A slightly modified version of a previously described model of secondary hyperalgesia was used. Two copper wires contained in a microdialysis catheter were inserted in parallel over a length of 5 mm into the dermis of the right volar forearm. The wires were connected to a constant current stimulator controlled by a pulse generator to deliver rectangular and monophasic pulses with a duration of 0.5 mg at 2 Hz. Over a period of 15 min, the current was increased by targeting a pain rating of 5 on an 11-point numeric rating scale (0 = no pain and 10 = maximum tolerable pain) until the hyperalgesic area surrounding the stimulation site was fully established. Once the area was established, the current was held constant. Percent change from baseline in size (area) of secondary hyperalgesia after cessation of remifentanil infusion was calculated per group. (NCT01222091)
Timeframe: Baseline; 15 min post remifentanil (REM) infusion; 60 min post REM infusion

,
Interventionpercentage of change (Number)
15 min post remifentanil infusion60 min post remifentanil infusion
Placebo-34141.5
Propranolol-28-19

Opioid Consumption

Number of morphine equivalents used by subject during first 24 hours after discharge from Post-Anesthesia Care Unit (NCT01430182)
Timeframe: First 24 hours after discharge from Post-Anesthesia Care Unit

Interventionmg of morphine IV equivalents (Mean)
Methadone 0.2 mg/kg50.9
Morphine 0.2 mg/kg37.5

Reviews

77 reviews available for methadone and Pain

ArticleYear
Problematic Opioid Use Among Older Adults: Epidemiology, Adverse Outcomes and Treatment Considerations.
    Drugs & aging, 2021, Volume: 38, Issue:12

    Topics: Aged; Analgesics, Opioid; Buprenorphine; Humans; Methadone; Opioid-Related Disorders; Pain

2021
Methadone Switching for Cancer Pain: A New Classification of Initiation Protocols, Based on a Critical Literature Review.
    Journal of palliative medicine, 2021, Volume: 24, Issue:12

    Topics: Analgesics, Opioid; Cancer Pain; Humans; Methadone; Morphine; Neoplasms; Pain; Randomized Controlled

2021
Opioid-induced Neurotoxicity in Patients with Cancer Pain.
    Current treatment options in oncology, 2023, Volume: 24, Issue:10

    Topics: Analgesics, Opioid; Cancer Pain; Humans; Methadone; Neoplasms; Pain; Palliative Care

2023
Anesthesia update - Incorporating methadone into companion animal anesthesia and analgesic protocols: A narrative review.
    The Canadian veterinary journal = La revue veterinaire canadienne, 2023, Volume: 64, Issue:11

    Topics: Analgesics, Opioid; Anesthesia; Animals; Cat Diseases; Cats; Dog Diseases; Dogs; Methadone; Pain; Pe

2023
Why equianalgesic tables are only part of the answer to equianalgesia.
    Annals of palliative medicine, 2020, Volume: 9, Issue:2

    Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Dosage Calculations; Humans; Methadone; M

2020
Methadone: Maximizing Safety and Efficacy for Pain Control in Patients with Cancer.
    Hematology/oncology clinics of North America, 2018, Volume: 32, Issue:3

    Topics: Half-Life; Humans; Inappropriate Prescribing; Methadone; Neoplasms; Pain

2018
From Tramadol to Methadone: Opioids in the Treatment of Pain and Dyspnea in Pediatric Palliative Care.
    The Clinical journal of pain, 2019, Volume: 35, Issue:6

    Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Dyspnea; Humans; Infant; Infant, Newborn; M

2019
Metabolic and toxicological considerations of the opioid replacement therapy and analgesic drugs: methadone and buprenorphine.
    Expert opinion on drug metabolism & toxicology, 2013, Volume: 9, Issue:6

    Topics: Analgesics, Opioid; Animals; Buprenorphine; Drug Interactions; Humans; Methadone; Opiate Substitutio

2013
Transdermal fentanyl for cancer pain.
    The Cochrane database of systematic reviews, 2013, Oct-05, Issue:10

    Topics: Administration, Cutaneous; Analgesics, Opioid; Fentanyl; Humans; Methadone; Morphine; Neoplasms; Pai

2013
Behavioral effects of perinatal opioid exposure.
    Life sciences, 2014, May-28, Volume: 104, Issue:1-2

    Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Female; Humans; Illicit Drugs; Infant, Ne

2014
Therapeutic challenges in cancer pain management: a systematic review of methadone.
    Journal of pain & palliative care pharmacotherapy, 2014, Volume: 28, Issue:3

    Topics: Analgesics, Opioid; Humans; Methadone; Neoplasms; Pain; Pain Management

2014
Methods of Rotation From Another Strong Opioid to Methadone for the Management of Cancer Pain: A Systematic Review of the Available Evidence.
    Journal of pain and symptom management, 2015, Volume: 50, Issue:2

    Topics: Analgesics, Opioid; Humans; Methadone; Neoplasms; Pain; Pain Management

2015
The US Congressional "Decade on Pain Control and Research" 2001-2011: A Review.
    Journal of pain & palliative care pharmacotherapy, 2015, Volume: 29, Issue:3

    Topics: Analgesics, Opioid; Biomedical Research; Drug and Narcotic Control; Humans; Methadone; Opioid-Relate

2015
Methadone analgesia in the critically ill.
    Journal of critical care, 2016, Volume: 34

    Topics: Adult; Analgesics, Opioid; Child; Critical Illness; Delirium; Humans; Intensive Care Units; Methadon

2016
The use of methadone to facilitate opioid weaning in pediatric critical care patients: a systematic review of the literature and meta-analysis.
    Paediatric anaesthesia, 2017, Volume: 27, Issue:3

    Topics: Analgesics, Opioid; Child; Critical Care; Humans; Methadone; Pain; Substance Withdrawal Syndrome

2017
Methadone for cancer pain.
    The Cochrane database of systematic reviews, 2017, 02-08, Volume: 2

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Humans; Methadone; Middle Aged; Morphine; Neopla

2017
Equianalgesia: applying evidence-based practice guidelines.
    Clinical journal of oncology nursing, 2008, Volume: 12, Issue:3

    Topics: Analgesia; Analgesics, Opioid; Codeine; Drug Monitoring; Evidence-Based Medicine; Humans; Hydromorph

2008
Pediatric palliative care: use of opioids for the management of pain.
    Paediatric drugs, 2009, Volume: 11, Issue:2

    Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Buprenorphine; Child; Delayed-A

2009
Methadone-induced mortality in the treatment of chronic pain: role of QT prolongation.
    Cardiology journal, 2009, Volume: 16, Issue:3

    Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Chronic Disease; Delayed Rectifier Potassium Channels; ERG

2009
Opioids in people with cancer-related pain.
    BMJ clinical evidence, 2008, Jul-31, Volume: 2008

    Topics: Administration, Oral; Analgesics; Analgesics, Opioid; Codeine; Fentanyl; Humans; Methadone; Neoplasm

2008
Clinical approaches to special issues related to opioid therapy.
    Seminars in oncology nursing, 2009, Volume: 25, Issue:2 Suppl 1

    Topics: Analgesics, Opioid; Humans; Methadone; Neoplasms; Nurse's Role; Nursing Assessment; Nursing Methodol

2009
[Methadone treatment and its dangers].
    Medicina (Kaunas, Lithuania), 2009, Volume: 45, Issue:5

    Topics: Adult; Analgesics, Opioid; Child, Preschool; Drug Interactions; Drug Overdose; Electrocardiography;

2009
The role of methadone in cancer pain treatment--a review.
    International journal of clinical practice, 2009, Volume: 63, Issue:7

    Topics: Analgesics, Opioid; Drug Administration Routes; Drug Administration Schedule; Drug Interactions; Hum

2009
Methadone deaths: risk factors in pain and addicted populations.
    Journal of general internal medicine, 2010, Volume: 25, Issue:4

    Topics: Analgesics, Opioid; Chronic Disease; Death, Sudden, Cardiac; Drug Overdose; Humans; Methadone; Opiat

2010
[Treatment of acute pain during drug-assisted rehabilitation].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2010, Apr-08, Volume: 130, Issue:7

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents

2010
Morphine to methadone conversion: an interpretation of published data.
    The American journal of hospice & palliative care, 2011, Volume: 28, Issue:2

    Topics: Analgesics, Opioid; Humans; Methadone; Morphine; Pain; Palliative Care; Receptors, N-Methyl-D-Aspart

2011
Review of cancer pain management in patients receiving maintenance methadone therapy.
    The American journal of hospice & palliative care, 2011, Volume: 28, Issue:3

    Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Huma

2011
Methadone: marvelous, malevolent, or merely misunderstood?
    The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 2011, Volume: 26, Issue:1

    Topics: Analgesics, Opioid; Humans; Methadone; Pain; Pain Management

2011
Prescription pain medication dependence.
    The American journal of psychiatry, 2011, Volume: 168, Issue:5

    Topics: Analgesics; Buprenorphine; Humans; Methadone; Naltrexone; Narcotic Antagonists; Opiate Substitution

2011
A review of forensic implications of opioid prescribing with examples from malpractice cases involving opioid-related overdose.
    Pain medicine (Malden, Mass.), 2011, Volume: 12 Suppl 2

    Topics: Analgesics, Opioid; Chronic Disease; Drug Overdose; Drug Prescriptions; Forensic Medicine; Humans; K

2011
Is oral methadone better than placebo or other oral/transdermal opioids in the management of pain?
    Palliative medicine, 2011, Volume: 25, Issue:5

    Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Humans; Methadone; Neoplasms; P

2011
Acute pain management in opioid-tolerant patients: a growing challenge.
    Anaesthesia and intensive care, 2011, Volume: 39, Issue:5

    Topics: Acute Disease; Analgesics; Analgesics, Opioid; Animals; Australia; Buprenorphine; Buprenorphine, Nal

2011
The effect of age on opioid switching to methadone: a systematic review.
    Journal of palliative medicine, 2012, Volume: 15, Issue:3

    Topics: Age Factors; Analgesics, Opioid; Drug Substitution; Humans; Methadone; Pain

2012
Management of opioid substitution therapy during medical intervention.
    Internal medicine journal, 2012, Volume: 42, Issue:3

    Topics: Analgesics; Australia; Buprenorphine; Comorbidity; Drug Interactions; Female; Humans; Liver Diseases

2012
The use of methadone for cancer pain.
    Hematology/oncology clinics of North America, 2002, Volume: 16, Issue:3

    Topics: Analgesics, Opioid; Attitude of Health Personnel; Biological Availability; Child; Clinical Protocols

2002
Management of the hospitalized injection drug user.
    Infectious disease clinics of North America, 2002, Volume: 16, Issue:3

    Topics: Chronic Disease; Comorbidity; Female; Hospitalization; Humans; Male; Methadone; Pain; Severity of Il

2002
Intrathecal therapy for chronic pain.
    Stereotactic and functional neurosurgery, 2001, Volume: 77, Issue:1-4

    Topics: Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Hum

2001
Clinical use of methadone.
    Journal of pain & palliative care pharmacotherapy, 2002, Volume: 16, Issue:1

    Topics: Analgesics, Opioid; Biological Availability; Dosage Forms; Drug Administration Schedule; Drug Intera

2002
Morphine is not the only analgesic in palliative care: literature review.
    Journal of advanced nursing, 2004, Volume: 45, Issue:5

    Topics: Analgesics; Analgesics, Opioid; Fentanyl; Humans; Ketamine; Methadone; Morphine; Neoplasms; Pain; Pa

2004
Methadone for cancer pain.
    The Cochrane database of systematic reviews, 2004, Issue:2

    Topics: Analgesics, Opioid; Humans; Methadone; Morphine; Neoplasms; Pain; Pain Measurement; Randomized Contr

2004
Methadone: applied pharmacology and use as adjunctive treatment in chronic pain.
    Postgraduate medical journal, 2004, Volume: 80, Issue:949

    Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Opioid-Related Disorders; Pain

2004
Cancer pain management in children.
    Palliative medicine, 2004, Volume: 18, Issue:7

    Topics: Analgesics, Opioid; Anesthesia, Conduction; Child; Chronic Disease; Fentanyl; Humans; Injections, Sp

2004
Pain and terminal delirium research in the elderly.
    Clinics in geriatric medicine, 2005, Volume: 21, Issue:1

    Topics: Aged; Algorithms; Analgesics, Opioid; Anti-Infective Agents; Constipation; Delirium; Drug Interactio

2005
Methadone treatment for pain states.
    American family physician, 2005, Apr-01, Volume: 71, Issue:7

    Topics: Analgesics, Opioid; Chronic Disease; Drug Costs; Drug Interactions; Humans; Methadone; Pain; Therape

2005
A review of the use of methadone for the treatment of chronic noncancer pain.
    Pain research & management, 2005,Autumn, Volume: 10, Issue:3

    Topics: Analgesics, Opioid; Canada; Chronic Disease; Humans; Legislation, Drug; Methadone; Pain

2005
Acute pain management for patients receiving maintenance methadone or buprenorphine therapy.
    Annals of internal medicine, 2006, Jan-17, Volume: 144, Issue:2

    Topics: Acute Disease; Adult; Analgesics, Opioid; Buprenorphine; Female; Heroin Dependence; Humans; Methadon

2006
Pharmacokinetics of methadone.
    Journal of pain & palliative care pharmacotherapy, 2005, Volume: 19, Issue:4

    Topics: Aged; Analgesics, Opioid; Area Under Curve; Biological Availability; Child; Cytochrome P-450 Enzyme

2005
Pharmacokinetics of methadone.
    Journal of pain & palliative care pharmacotherapy, 2005, Volume: 19, Issue:4

    Topics: Aged; Analgesics, Opioid; Area Under Curve; Biological Availability; Child; Cytochrome P-450 Enzyme

2005
Pharmacokinetics of methadone.
    Journal of pain & palliative care pharmacotherapy, 2005, Volume: 19, Issue:4

    Topics: Aged; Analgesics, Opioid; Area Under Curve; Biological Availability; Child; Cytochrome P-450 Enzyme

2005
Pharmacokinetics of methadone.
    Journal of pain & palliative care pharmacotherapy, 2005, Volume: 19, Issue:4

    Topics: Aged; Analgesics, Opioid; Area Under Curve; Biological Availability; Child; Cytochrome P-450 Enzyme

2005
Difficult cases in pain management: use of methadone in a multifactorial approach.
    Clinical journal of oncology nursing, 2006, Volume: 10, Issue:1

    Topics: Administration, Oral; Aged; Analgesics, Opioid; Communication; Drug Monitoring; Female; Humans; Inte

2006
Difficult pain.
    BMJ (Clinical research ed.), 2006, May-06, Volume: 332, Issue:7549

    Topics: Acupuncture; Analgesia; Analgesics, Opioid; Forecasting; Humans; Methadone; Nervous System Diseases;

2006
Methadone for treatment of cancer pain.
    Current oncology reports, 2006, Volume: 8, Issue:4

    Topics: Analgesics, Opioid; Humans; Methadone; Neoplasms; Pain

2006
Pharmacological approaches to the management of pain in the neonatal intensive care unit.
    Journal of perinatology : official journal of the California Perinatal Association, 2007, Volume: 27 Suppl 1

    Topics: Analgesics; Analgesics, Opioid; Female; Humans; Infant, Newborn; Infant, Premature; Intensive Care U

2007
Practical guide to opioids and their complications in managing cancer pain. What oncologists need to know.
    Oncology (Williston Park, N.Y.), 2007, Volume: 21, Issue:10

    Topics: Analgesics, Opioid; Chronic Disease; Dose-Response Relationship, Drug; Drug Administration Routes; D

2007
The management of pain in children with life-limiting illnesses.
    Pediatric clinics of North America, 2007, Volume: 54, Issue:5

    Topics: Analgesics, Opioid; Child; Chronic Disease; Codeine; Fentanyl; Humans; Hydromorphone; Ketamine; Meth

2007
Methadone for cancer pain.
    The Cochrane database of systematic reviews, 2007, Oct-17, Issue:4

    Topics: Analgesics, Opioid; Humans; Methadone; Morphine; Neoplasms; Pain; Pain Measurement; Randomized Contr

2007
Palliative care pharmacotherapy literature summaries and analyses.
    Journal of pain & palliative care pharmacotherapy, 2007, Volume: 21, Issue:3

    Topics: Analgesics, Opioid; Cardiovascular Diseases; Clinical Trials as Topic; Cyclooxygenase 2 Inhibitors;

2007
Treatment of opioid-dependent pregnant women: clinical and research issues.
    Journal of substance abuse treatment, 2008, Volume: 35, Issue:3

    Topics: Analgesics, Opioid; Buprenorphine; Clinical Trials as Topic; Decision Making; Female; Humans; Infant

2008
Clinical pharmacology of methadone for pain.
    Acta anaesthesiologica Scandinavica, 2008, Volume: 52, Issue:7

    Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Chronic Disease; Clinical Trials as Topic; Drug Interactio

2008
Interindividual variability of methadone response: impact of genetic polymorphism.
    Molecular diagnosis & therapy, 2008, Volume: 12, Issue:2

    Topics: ATP-Binding Cassette Transporters; Cytochrome P-450 Enzyme System; Drug Interactions; Genetic Hetero

2008
Effectiveness of opioids in the treatment of chronic non-cancer pain.
    Pain physician, 2008, Volume: 11, Issue:2 Suppl

    Topics: Analgesics, Opioid; Drug Administration Schedule; Fentanyl; Humans; Methadone; Morphine; Oxycodone;

2008
Consensus guideline on parenteral methadone use in pain and palliative care.
    Palliative & supportive care, 2008, Volume: 6, Issue:2

    Topics: Hospice Care; Humans; Methadone; Pain; Palliative Care; Practice Guidelines as Topic

2008
Recent advances in acute pain management.
    Current problems in pediatrics, 1995, Volume: 25, Issue:3

    Topics: Acute Disease; Administration, Oral; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics;

1995
Should people taking opioids for medical reasons be allowed to work and drive?
    Addiction (Abingdon, England), 1996, Volume: 91, Issue:11

    Topics: Accidents, Occupational; Accidents, Traffic; Analgesics, Opioid; Heroin Dependence; Humans; Long-Ter

1996
[Treatment of pain in oncology].
    Tumori, 1997, Volume: 83, Issue:2 Suppl

    Topics: Administration, Cutaneous; Analgesics, Opioid; Anesthetics, Dissociative; Diphosphonates; Fentanyl;

1997
Opioid rotation for cancer pain: rationale and clinical aspects.
    Cancer, 1999, Nov-01, Volume: 86, Issue:9

    Topics: Analgesics, Opioid; Fentanyl; Humans; Hydromorphone; Methadone; Morphine; Narcotics; Neoplasms; Pain

1999
Opioid switch to oral methadone in cancer pain.
    Current opinion in oncology, 2000, Volume: 12, Issue:4

    Topics: Administration, Oral; Analgesics, Opioid; Combined Modality Therapy; Cross-Sectional Studies; Dose-R

2000
Methadone for relief of cancer pain: a review of pharmacokinetics, pharmacodynamics, drug interactions and protocols of administration.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2001, Volume: 9, Issue:2

    Topics: Analgesics, Opioid; Drug Administration Routes; Drug Interactions; Humans; Methadone; Neoplasms; Pai

2001
[Treatment of pain in cancer with systemically administered opioids].
    Nederlands tijdschrift voor geneeskunde, 2001, May-19, Volume: 145, Issue:20

    Topics: Analgesics, Opioid; Delayed-Action Preparations; Drug Administration Schedule; Humans; Infusion Pump

2001
Strategies for the treatment of cancer pain in the new millennium.
    Drugs, 2001, Volume: 61, Issue:7

    Topics: Analgesics, Opioid; Cannabinoids; Dose-Response Relationship, Drug; Drug Therapy, Combination; Human

2001
Methadone: the renaissance.
    Journal of palliative care, 2001,Summer, Volume: 17, Issue:2

    Topics: Analgesics, Opioid; Animals; Consumer Product Safety; Dose-Response Relationship, Drug; Humans; Meth

2001
Methadone use in cancer patients with pain: a review.
    Journal of palliative medicine, 2002, Volume: 5, Issue:1

    Topics: Analgesics, Opioid; Drug Interactions; Humans; Methadone; Neoplasms; Pain

2002
[Delayed-action opioids--limitations and advantages].
    Ugeskrift for laeger, 1990, Apr-02, Volume: 152, Issue:14

    Topics: Buprenorphine; Delayed-Action Preparations; Humans; Methadone; Morphine; Pain; Palliative Care

1990
Neuropeptide effects on brain development.
    Journal de physiologie, 1985, Volume: 80, Issue:4

    Topics: 5,7-Dihydroxytryptamine; Adrenocorticotropic Hormone; Animals; Animals, Newborn; Behavior, Animal; B

1985
The pharmacologic management of pain in children.
    Comprehensive therapy, 1989, Volume: 15, Issue:10

    Topics: Analgesia, Epidural; Analgesics; Child; Child, Preschool; Codeine; Fentanyl; Humans; Infant; Meperid

1989
Future trends in regional spinal opioids.
    International anesthesiology clinics, 1986,Summer, Volume: 24, Issue:2

    Topics: Analgesics, Opioid; Anesthesia, Epidural; Animals; Humans; Injections, Spinal; Kinetics; Lipids; Met

1986
The opioid-dependent patient with acute pain.
    Hospital practice (Office ed.), 1987, Nov-15, Volume: 22, Issue:11

    Topics: Acute Disease; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pain; Pain, Postoperative; Su

1987
Drug therapy: analgetic drugs--the potent analgetics.
    The New England journal of medicine, 1972, Feb-03, Volume: 286, Issue:5

    Topics: Analgesics; Blood Circulation; Fentanyl; Humans; Intestines; Levallorphan; Meperidine; Methadone; Me

1972
Editorial: Analgesia in myocardial infarction.
    British heart journal, 1974, Volume: 36, Issue:2

    Topics: Analgesia; Analgesics; Animals; Blood Pressure; Cyclizine; Heart Arrest; Heroin; Humans; Injections,

1974

Trials

55 trials available for methadone and Pain

ArticleYear
Hyperbaric Oxygen Therapy for Pain, Opioid Withdrawal, and Related Symptoms: A Pilot Randomized Controlled Trial.
    Pain management nursing : official journal of the American Society of Pain Management Nurses, 2022, Volume: 23, Issue:5

    Topics: Adult; Analgesics, Opioid; Humans; Hyperbaric Oxygenation; Methadone; Opioid-Related Disorders; Oxyg

2022
Conversion ratios for opioid switching: a pragmatic study.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022, Dec-29, Volume: 31, Issue:1

    Topics: Analgesics, Opioid; Humans; Methadone; Neoplasms; Pain; Palliative Care

2022
Delta-9-tetrahydrocannabinol modulates pain sensitivity among persons receiving opioid agonist therapy for opioid use disorder: A within-subject, randomized, placebo-controlled laboratory study.
    Addiction biology, 2023, Volume: 28, Issue:9

    Topics: Analgesics, Opioid; Dronabinol; Female; Humans; Male; Methadone; Opioid-Related Disorders; Pain

2023
A single-institution, randomized, pilot study evaluating the efficacy of gabapentin and methadone for patients undergoing chemoradiation for head and neck squamous cell cancer.
    Cancer, 2020, 04-01, Volume: 126, Issue:7

    Topics: Adult; Aged; Analgesics; Chemoradiotherapy; Dose-Response Relationship, Drug; Female; Gabapentin; Hu

2020
Pain in methadone patients: Time to address undertreatment and suicide risk (ANRS-Methaville trial).
    PloS one, 2017, Volume: 12, Issue:5

    Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Female; Humans; Inappropriate Prescribing; Male; Methad

2017
Can Saliva and Plasma Methadone Concentrations Be Used for Enantioselective Pharmacokinetic and Pharmacodynamic Studies in Patients With Advanced Cancer?
    Clinical therapeutics, 2017, Volume: 39, Issue:9

    Topics: Aged; Analgesics, Opioid; Chromatography, High Pressure Liquid; Female; Humans; Male; Methadone; Mid

2017
Sedative and antinociceptive effects of different detomidine constant rate infusions, with or without methadone in standing horses.
    Equine veterinary journal, 2019, Volume: 51, Issue:4

    Topics: Animals; Conscious Sedation; Drug Therapy, Combination; Female; Horses; Hypnotics and Sedatives; Imi

2019
Comparison of perioperative analgesic efficacy between methadone and butorphanol in cats.
    Journal of the American Veterinary Medical Association, 2013, Sep-15, Volume: 243, Issue:6

    Topics: Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Butorphanol; Cat Disea

2013
Antinociceptive effects of methadone combined with detomidine or acepromazine in horses.
    Equine veterinary journal, 2016, Volume: 48, Issue:5

    Topics: Acepromazine; Animals; Drug Therapy, Combination; Electric Stimulation; Horse Diseases; Horses; Hot

2016
Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease.
    Pediatric blood & cancer, 2016, Volume: 63, Issue:12

    Topics: Adolescent; Analgesics, Opioid; Anemia, Sickle Cell; Child; Female; Humans; Male; Methadone; Pain

2016
[Effects of morphine, butorphanol and levomethadone in different doses on thermal nociceptive thresholds in horses].
    Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere, 2017, Apr-19, Volume: 45, Issue:2

    Topics: Analgesics; Animals; Butorphanol; Horse Diseases; Horses; Hot Temperature; Methadone; Morphine; Pain

2017
Experience of methadone therapy in 100 consecutive chronic pain patients in a multidisciplinary pain center.
    Pain medicine (Malden, Mass.), 2008, Volume: 9, Issue:7

    Topics: Ambulatory Care; Analgesics, Opioid; Canada; Chronic Disease; Female; Humans; Male; Methadone; Middl

2008
The role of methadone in opioid rotation-a Polish experience.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2009, Volume: 17, Issue:5

    Topics: Adult; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Tolerance; Female; Humans; M

2009
Early switching from morphine to methadone is not improved by acetaminophen in the analgesia of oncologic patients: a prospective, randomized, double-blind, placebo-controlled study.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2010, Volume: 18, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opi

2010
The effect of oral methadone on the QTc interval in advanced cancer patients: a prospective pilot study.
    Journal of palliative medicine, 2010, Volume: 13, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relationship, Drug; Electrocardiog

2010
The use of fentanyl buccal tablets as breakthrough medication in patients receiving chronic methadone therapy: an open label preliminary study.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2011, Volume: 19, Issue:3

    Topics: Administration, Buccal; Adult; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Tole

2011
Plasma concentrations and behavioral, antinociceptive, and physiologic effects of methadone after intravenous and oral transmucosal administration in cats.
    American journal of veterinary research, 2011, Volume: 72, Issue:6

    Topics: Administration, Buccal; Analgesia; Analgesics, Opioid; Animals; Behavior, Animal; Catheterization, C

2011
How to switch from morphine or oxycodone to methadone in cancer patients? a randomised clinical phase II trial.
    European journal of cancer (Oxford, England : 1990), 2011, Volume: 47, Issue:16

    Topics: Administration, Oral; Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relationship, Drug;

2011
Serum concentrations of opioids when comparing two switching strategies to methadone for cancer pain.
    European journal of clinical pharmacology, 2012, Volume: 68, Issue:8

    Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans;

2012
Epidemiology of pain among outpatients in methadone maintenance treatment programs.
    Drug and alcohol dependence, 2013, Feb-01, Volume: 128, Issue:1-2

    Topics: Adult; Comorbidity; Female; Humans; Male; Methadone; Middle Aged; Opiate Substitution Treatment; Opi

2013
Epidural methadone results in dose-dependent analgesia in cancer pain, further enhanced by epidural dexamethasone.
    British journal of cancer, 2013, Feb-05, Volume: 108, Issue:2

    Topics: Adult; Aged; Analgesia, Epidural; Dexamethasone; Drug Administration Routes; Female; Humans; Lidocai

2013
Transcutaneous iontophoresis of methadone provokes local flushing and thermal hyperalgesia.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2003, Volume: 52, Issue:9

    Topics: Administration, Cutaneous; Adolescent; Adult; Female; Flushing; Hot Temperature; Humans; Hyperalgesi

2003
Methadone versus morphine as a first-line strong opioid for cancer pain: a randomized, double-blind study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Jan-01, Volume: 22, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Delayed-Action Preparation

2004
Methadone versus morphine as a first-line strong opioid for cancer pain: a randomized, double-blind study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Jan-01, Volume: 22, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Delayed-Action Preparation

2004
Methadone versus morphine as a first-line strong opioid for cancer pain: a randomized, double-blind study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Jan-01, Volume: 22, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Delayed-Action Preparation

2004
Methadone versus morphine as a first-line strong opioid for cancer pain: a randomized, double-blind study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Jan-01, Volume: 22, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Delayed-Action Preparation

2004
Characterization of the early pharmacodynamic profile of oral methadone for cancer-related breakthrough pain: a pilot study.
    Journal of pain and symptom management, 2004, Volume: 28, Issue:6

    Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Chronic Disease; Cross-Over Studies; Female;

2004
Significantly higher methadone dose for methadone maintenance treatment (MMT) patients with chronic pain.
    Pain, 2005, Volume: 113, Issue:3

    Topics: Adult; Analgesics, Opioid; Analysis of Variance; Benzodiazepines; Case-Control Studies; Chronic Dise

2005
Measurement of QTc in patients receiving chronic methadone therapy.
    Journal of pain and symptom management, 2005, Volume: 29, Issue:4

    Topics: Electrocardiography; Female; Heart Rate; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Pa

2005
Rapid switching between transdermal fentanyl and methadone in cancer patients.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Aug-01, Volume: 23, Issue:22

    Topics: Administration, Cutaneous; Analgesics, Opioid; Female; Fentanyl; Humans; Male; Methadone; Middle Age

2005
Intermittent subcutaneous methadone administration in the management of cancer pain.
    Journal of pain & palliative care pharmacotherapy, 2005, Volume: 19, Issue:2

    Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Humans; Injec

2005
Opioid rotation to methadone at home.
    Journal of pain and symptom management, 2006, Volume: 31, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Female; Home Care Services; Humans; Male; Methad

2006
Brief report: Training internists in shared decision making about chronic opioid treatment for noncancer pain.
    Journal of general internal medicine, 2006, Volume: 21, Issue:4

    Topics: Analgesics, Opioid; Attitude of Health Personnel; Chronic Disease; Decision Making; Humans; Internal

2006
Analgesic effects of subarachnoidally administered hyperbaric opioids in horses.
    American journal of veterinary research, 2006, Volume: 67, Issue:6

    Topics: Analgesia; Analgesics, Opioid; Animals; Buprenorphine; Cross-Over Studies; Female; Horse Diseases; H

2006
Methadone in the treatment of pain and terminal delirum in advanced cancer patients.
    Palliative & supportive care, 2005, Volume: 3, Issue:4

    Topics: Aged; Analgesics, Opioid; Delirium; Dose-Response Relationship, Drug; Drug Administration Schedule;

2005
The effect of opioids on sleep architecture.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2007, Feb-15, Volume: 3, Issue:1

    Topics: Adolescent; Adult; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Admini

2007
The effect of opioids on sleep architecture.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2007, Feb-15, Volume: 3, Issue:1

    Topics: Adolescent; Adult; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Admini

2007
The effect of opioids on sleep architecture.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2007, Feb-15, Volume: 3, Issue:1

    Topics: Adolescent; Adult; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Admini

2007
The effect of opioids on sleep architecture.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2007, Feb-15, Volume: 3, Issue:1

    Topics: Adolescent; Adult; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Admini

2007
Antinociceptive effects of high-dose remifentanil in male methadone-maintained patients.
    European journal of pain (London, England), 2008, Volume: 12, Issue:7

    Topics: Adult; Analgesics, Opioid; Cold Temperature; Drug Interactions; Drug Tolerance; Humans; Infusions, I

2008
Custom-made capsules and suppositories of methadone for patients on high-dose opioids for cancer pain.
    Pain, 1995, Volume: 62, Issue:2

    Topics: Aged; Analgesics, Opioid; Capsules; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Female;

1995
Stereoselective pharmacokinetics of methadone in chronic pain patients.
    Therapeutic drug monitoring, 1996, Volume: 18, Issue:3

    Topics: Aged; Analgesics, Opioid; Biological Availability; Chromatography, High Pressure Liquid; Chronic Dis

1996
Patient-controlled analgesia with oral methadone in cancer pain: preliminary report.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1996, Volume: 7, Issue:6

    Topics: Administration, Oral; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Dose-Response Relatio

1996
Pain perception of intravenous heroin users on maintenance therapy with levomethadone.
    Pharmacopsychiatry, 1996, Volume: 29, Issue:5

    Topics: Adult; Female; Heroin Dependence; Humans; Male; Methadone; Narcotics; Pain; Pain Measurement; Single

1996
Opioid-sparing effect of diclofenac in cancer pain.
    Journal of pain and symptom management, 1997, Volume: 14, Issue:1

    Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Di

1997
Methadone titration in opioid-resistant cancer pain.
    European journal of cancer care, 1999, Volume: 8, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Drug Administration Schedu

1999
Differences in the ratios of morphine to methadone in patients with neuropathic pain versus non-neuropathic pain.
    Journal of pain and symptom management, 1999, Volume: 18, Issue:2

    Topics: Adult; Aged; Analgesics, Opioid; Drug Administration Schedule; Female; Humans; Male; Methadone; Midd

1999
Pain responses in methadone-maintained opioid abusers.
    Journal of pain and symptom management, 2000, Volume: 20, Issue:4

    Topics: Adult; Cold Temperature; Drug Interactions; Female; Humans; Hydromorphone; Ketorolac; Male; Methadon

2000
Pain responses in methadone-maintained opioid abusers.
    Journal of pain and symptom management, 2000, Volume: 20, Issue:4

    Topics: Adult; Cold Temperature; Drug Interactions; Female; Humans; Hydromorphone; Ketorolac; Male; Methadon

2000
Pain responses in methadone-maintained opioid abusers.
    Journal of pain and symptom management, 2000, Volume: 20, Issue:4

    Topics: Adult; Cold Temperature; Drug Interactions; Female; Humans; Hydromorphone; Ketorolac; Male; Methadon

2000
Pain responses in methadone-maintained opioid abusers.
    Journal of pain and symptom management, 2000, Volume: 20, Issue:4

    Topics: Adult; Cold Temperature; Drug Interactions; Female; Humans; Hydromorphone; Ketorolac; Male; Methadon

2000
Switching from morphine to methadone to improve analgesia and tolerability in cancer patients: a prospective study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Jun-01, Volume: 19, Issue:11

    Topics: Administration, Oral; Analgesics, Opioid; Drug Administration Schedule; Female; Humans; Male; Methad

2001
Switching from morphine to methadone to improve analgesia and tolerability in cancer patients: a prospective study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Jun-01, Volume: 19, Issue:11

    Topics: Administration, Oral; Analgesics, Opioid; Drug Administration Schedule; Female; Humans; Male; Methad

2001
Switching from morphine to methadone to improve analgesia and tolerability in cancer patients: a prospective study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Jun-01, Volume: 19, Issue:11

    Topics: Administration, Oral; Analgesics, Opioid; Drug Administration Schedule; Female; Humans; Male; Methad

2001
Switching from morphine to methadone to improve analgesia and tolerability in cancer patients: a prospective study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Jun-01, Volume: 19, Issue:11

    Topics: Administration, Oral; Analgesics, Opioid; Drug Administration Schedule; Female; Humans; Male; Methad

2001
Pitfalls of opioid rotation: substituting another opioid for methadone in patients with cancer pain.
    Pain, 2002, Volume: 96, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Female; Fentanyl; Humans; Hydromorphone; Levorphanol; Male; Methado

2002
Analgesic, central, cardiovascular and endocrine effects of the enkephalin analogue Tyr-D.Arg-Gly-Phe(4NO2)-Pro-NH2 (443C81) in healthy volunteers.
    European journal of clinical pharmacology, 1990, Volume: 38, Issue:3

    Topics: Adult; Amino Acid Sequence; Analgesics; Analgesics, Opioid; Blood Pressure; Central Nervous System;

1990
Pharmacokinetic-pharmacodynamic relationships of methadone infusions in patients with cancer pain.
    Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:5

    Topics: Adult; Aged; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Humans; Infusions,

1990
Effects of an opiate on cold-induced pain and the CNS in healthy volunteers.
    Pain, 1985, Volume: 23, Issue:1

    Topics: Adult; Analgesics, Opioid; Blood Pressure; Central Nervous System; Cold Temperature; Dose-Response R

1985
The effects of naloxone on opiate and placebo analgesia in healthy volunteers.
    Psychopharmacology, 1985, Volume: 87, Issue:4

    Topics: Adult; Analgesia; Analgesics, Opioid; Codeine; Endorphins; Female; Humans; Male; Methadone; Middle A

1985
Dipipanone and nifedipine in cold induced pain; analgesia not due to skin warming.
    British journal of clinical pharmacology, 1987, Volume: 24, Issue:6

    Topics: Adult; Analgesics, Opioid; Blood Pressure; Cold Temperature; Double-Blind Method; Female; Heart Rate

1987
A comparative study of the efficacy and pharmacokinetics of oral methadone and morphine in the treatment of severe pain in patients with cancer.
    Pain, 1986, Volume: 25, Issue:3

    Topics: Administration, Oral; Aged; Biological Availability; Clinical Trials as Topic; Dose-Response Relatio

1986
A double-blind comparison of the efficacy of methadone and morphine in postoperative pain control.
    Anesthesiology, 1986, Volume: 64, Issue:3

    Topics: Abdomen; Adult; Blood Specimen Collection; Double-Blind Method; Drug Evaluation; Female; Humans; Mal

1986
A double-blind comparison of the efficacy of methadone and morphine in postoperative pain control.
    Anesthesiology, 1986, Volume: 64, Issue:3

    Topics: Abdomen; Adult; Blood Specimen Collection; Double-Blind Method; Drug Evaluation; Female; Humans; Mal

1986
A double-blind comparison of the efficacy of methadone and morphine in postoperative pain control.
    Anesthesiology, 1986, Volume: 64, Issue:3

    Topics: Abdomen; Adult; Blood Specimen Collection; Double-Blind Method; Drug Evaluation; Female; Humans; Mal

1986
A double-blind comparison of the efficacy of methadone and morphine in postoperative pain control.
    Anesthesiology, 1986, Volume: 64, Issue:3

    Topics: Abdomen; Adult; Blood Specimen Collection; Double-Blind Method; Drug Evaluation; Female; Humans; Mal

1986
Effects of diamorphine, methadone, morphine, and pentazocine in patients with suspected acute myocardial infarction.
    Lancet (London, England), 1969, May-31, Volume: 1, Issue:7605

    Topics: Acute Disease; Adult; Aged; Blood Pressure; Clinical Trials as Topic; Female; Heart Rate; Heroin; Hu

1969
The clinical testing of weak oral analgesics.
    Anaesthesia, 1974, Volume: 29, Issue:3

    Topics: Administration, Oral; Analgesics; Clinical Trials as Topic; Drug Evaluation; Humans; Meperidine; Met

1974
The quantitative measurement of joint changes in rheumatoid arthritis.
    Annals of physical medicine, 1968, Volume: 9, Issue:8

    Topics: Arthritis, Rheumatoid; Circadian Rhythm; Clinical Trials as Topic; Finger Joint; Fingers; Humans; Ma

1968
Post-operative pain relief: comparison of methadone and morphine when used concurrently with nitrous-oxide analgesia.
    British medical journal, 1966, Sep-10, Volume: 2, Issue:5514

    Topics: Humans; Methadone; Morphine; Nitrous Oxide; Pain; Postoperative Care

1966

Other Studies

348 other studies available for methadone and Pain

ArticleYear
The xanthene-9-spiro-4'-piperidine nucleus as a probe for opiate activity.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:10

    Topics: Analgesics, Opioid; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Mice; Molecular Structure; Mus

1989
A history of opioid abuse: Why buprenorphine is superior for the management of opioid use disorder and pain.
    Journal of opioid management, 2021, Volume: 17, Issue:7

    Topics: Analgesics, Opioid; Buprenorphine; Humans; Methadone; Naltrexone; Opiate Substitution Treatment; Opi

2021
The effect of a methadone reformulation on opioid agonist treatment outcomes: A population-based study in British Columbia, Canada, 2013-14.
    Journal of substance abuse treatment, 2022, Volume: 138

    Topics: Analgesics, Opioid; British Columbia; Humans; Methadone; Opiate Substitution Treatment; Opioid-Relat

2022
Association of polymorphisms in
    Pharmacogenomics, 2022, Volume: 23, Issue:5

    Topics: Analgesics, Opioid; beta-Arrestin 2; Cancer Pain; Humans; Methadone; Neoplasms; Pain; Polymorphism,

2022
Intraoperative Methadone Use in Pediatric Burn Patients.
    Journal of burn care & research : official publication of the American Burn Association, 2022, 11-02, Volume: 43, Issue:6

    Topics: Adult; Analgesics, Opioid; Burns; Child; Humans; Methadone; Morphine; Pain; Retrospective Studies

2022
Factors associated with retention on medications for opioid use disorder among a cohort of adults seeking treatment in the community.
    Addiction science & clinical practice, 2022, 03-07, Volume: 17, Issue:1

    Topics: Adult; Analgesics, Opioid; Buprenorphine; Drug Overdose; Female; Humans; Male; Methadone; Naltrexone

2022
Methadone as First-line Opioid for the Management of Cancer Pain.
    The oncologist, 2022, 04-05, Volume: 27, Issue:4

    Topics: Analgesics, Opioid; Cancer Pain; Humans; Methadone; Neoplasms; Pain; Prospective Studies

2022
Tracheostomy decreases continuous analgesia and sedation requirements.
    The journal of trauma and acute care surgery, 2022, 10-01, Volume: 93, Issue:4

    Topics: Adult; Aged; Analgesia; Analgesics; Anti-Anxiety Agents; Endrin; Female; Fentanyl; Humans; Hypnotics

2022
Lucid Dreams Associated with Pregabalin: Implications for Clinical Practice.
    Journal of pain & palliative care pharmacotherapy, 2022, Volume: 36, Issue:3

    Topics: Dreams; Female; Humans; Methadone; Pain; Pregabalin

2022
Characteristics of Prescription Opioid Analgesics in Pregnancy and Risk of Neonatal Opioid Withdrawal Syndrome in Newborns.
    JAMA network open, 2022, 08-01, Volume: 5, Issue:8

    Topics: Adult; Analgesics, Opioid; Codeine; Cohort Studies; Female; Humans; Hydrocodone; Hydromorphone; Infa

2022
Understanding motivations and use typologies of gabapentin with opioid agonist medications.
    Drug and alcohol dependence, 2023, 01-01, Volume: 242

    Topics: Analgesics, Opioid; Buprenorphine; Cross-Sectional Studies; Gabapentin; Humans; Methadone; Motivatio

2023
Understanding motivations and use typologies of gabapentin with opioid agonist medications.
    Drug and alcohol dependence, 2023, 01-01, Volume: 242

    Topics: Analgesics, Opioid; Buprenorphine; Cross-Sectional Studies; Gabapentin; Humans; Methadone; Motivatio

2023
Understanding motivations and use typologies of gabapentin with opioid agonist medications.
    Drug and alcohol dependence, 2023, 01-01, Volume: 242

    Topics: Analgesics, Opioid; Buprenorphine; Cross-Sectional Studies; Gabapentin; Humans; Methadone; Motivatio

2023
Understanding motivations and use typologies of gabapentin with opioid agonist medications.
    Drug and alcohol dependence, 2023, 01-01, Volume: 242

    Topics: Analgesics, Opioid; Buprenorphine; Cross-Sectional Studies; Gabapentin; Humans; Methadone; Motivatio

2023
Safety and preliminary outcomes of short-acting opioid agonist treatment (sOAT) for hospitalized patients with opioid use disorder.
    Addiction science & clinical practice, 2023, 02-24, Volume: 18, Issue:1

    Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Female; Humans; Hydromo

2023
Comparing National Methadone Equianalgesic Tools.
    Journal of pain & palliative care pharmacotherapy, 2023, Volume: 37, Issue:3

    Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Humans; Methadone; Pain; Palliative Care

2023
Feasibility of methadone for pain relief in first trimester abortion.
    Contraception, 2023, Volume: 125

    Topics: Abortion, Induced; Feasibility Studies; Female; Humans; Methadone; Pain; Pain Management; Pregnancy;

2023
Feasibility of methadone for pain relief in first trimester abortion (Boston, Massachusetts 2022).
    Contraception, 2023, Volume: 125

    Topics: Abortion, Induced; Boston; Feasibility Studies; Female; Humans; Massachusetts; Methadone; Pain; Preg

2023
Drug use patterns and factors related to the use and discontinuation of medications for opioid use disorder in the age of fentanyl: findings from a mixed-methods study of people who use drugs.
    Substance abuse treatment, prevention, and policy, 2023, 05-22, Volume: 18, Issue:1

    Topics: Analgesics, Opioid; Benzodiazepines; Buprenorphine; Crack Cocaine; Drug Overdose; Fentanyl; Heroin;

2023
Switching to Intravenous Methadone in Advanced Cancer Patients: A Retrospective Analysis.
    Journal of pain and symptom management, 2023, Volume: 66, Issue:4

    Topics: Analgesics, Opioid; Humans; Methadone; Neoplasms; Pain; Retrospective Studies

2023
Rescue Analgesia for Opioid-Dependent Individuals on Opioid Agonist Treatment during Hospitalization: Adherence to Guideline Treatment.
    European addiction research, 2023, Volume: 29, Issue:4

    Topics: Adult; Analgesics; Analgesics, Opioid; Female; Hospitalization; Humans; Male; Methadone; Middle Aged

2023
Perioperative Methadone: Perilous or Pain Panacea?
    Anesthesia and analgesia, 2023, 07-01, Volume: 137, Issue:1

    Topics: Analgesics, Opioid; Humans; Methadone; Pain; Pain, Postoperative

2023
Assessing the impact of the slow-release oral morphine drug shortages in Ontario, Canada: A population-based time series analysis.
    The International journal on drug policy, 2023, Volume: 118

    Topics: Administration, Oral; Analgesics, Opioid; Delayed-Action Preparations; Female; Humans; Male; Methado

2023
Retrospective analysis reveals significant association of hypoglycemia with tramadol and methadone in contrast to other opioids.
    Scientific reports, 2019, 08-28, Volume: 9, Issue:1

    Topics: Adult; Aged; Analgesics, Opioid; Databases, Factual; Female; Humans; Hypoglycemia; Male; Methadone;

2019
Comparing Methadone Rotation to Consensus Opinion.
    Journal of pain and symptom management, 2020, Volume: 59, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Drug Substitution; Female; Humans; Male; Methado

2020
Pain outcomes among patients after cesarean consuming buprenorphine or methadone and opioid-naïve patients.
    Journal of clinical anesthesia, 2020, Volume: 65

    Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opioid-Related Disorders; Pain; Pregna

2020
Alexithymia and pain experience among patients using methadone-maintenance therapy.
    Drug and alcohol dependence, 2021, 01-01, Volume: 218

    Topics: Adult; Affective Symptoms; Catastrophization; Emotions; Humans; Male; Methadone; Middle Aged; Opiate

2021
Plasma levels of a methadone constant rate infusion and their corresponding effects on thermal and mechanical nociceptive thresholds in dogs.
    BMC veterinary research, 2021, Jan-18, Volume: 17, Issue:1

    Topics: Administration, Intravenous; Analgesics, Opioid; Animals; Bradycardia; Cross-Over Studies; Dogs; Fem

2021
A Virtual Reality Meditative Intervention Modulates Pain and the Pain Neuromatrix in Patients with Opioid Use Disorder.
    Pain medicine (Malden, Mass.), 2021, Nov-26, Volume: 22, Issue:11

    Topics: Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Pain; Prospectiv

2021
Pronounced Regional Disparities in United States Methadone Distribution.
    The Annals of pharmacotherapy, 2022, Volume: 56, Issue:3

    Topics: Analgesics, Opioid; Buprenorphine; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related

2022
Methadone for Palliative Care Providers: A Case-Based Flipped Classroom Module for Faculty and Fellows.
    MedEdPORTAL : the journal of teaching and learning resources, 2021, Volume: 17

    Topics: Faculty; Humans; Methadone; Pain; Pain Management; Palliative Care; United States

2021
Methadone Prescribing and Overdose and the Association with Medicaid Preferred Drug List Policies - United States, 2007-2014.
    MMWR. Morbidity and mortality weekly report, 2017, Mar-31, Volume: 66, Issue:12

    Topics: Databases, Factual; Drug Overdose; Drug Prescriptions; Health Policy; Humans; Medicaid; Methadone; P

2017
Methadone-Induced Neurotoxicity in Advanced Cancer: A Case Report.
    Journal of palliative medicine, 2017, Volume: 20, Issue:9

    Topics: Analgesics, Opioid; Humans; Male; Methadone; Middle Aged; Neoplasms; Neurotoxicity Syndromes; Pain;

2017
Methadone Dose Selection for Treatment of Pain Compared with Consensus Recommendations.
    Journal of palliative medicine, 2017, Volume: 20, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Humans

2017
Prevalence of pain and its socio-demographic and clinical correlates among heroin-dependent patients receiving methadone maintenance treatment.
    Scientific reports, 2017, 08-18, Volume: 7, Issue:1

    Topics: Adult; Cross-Sectional Studies; Female; Heroin; Heroin Dependence; Humans; Male; Methadone; Middle A

2017
Opioid tapering in patients with prescription opioid use disorder: A retrospective study.
    Scandinavian journal of pain, 2017, Volume: 17

    Topics: Analgesics, Opioid; Chronic Pain; Drug Prescriptions; Female; Humans; Male; Methadone; Middle Aged;

2017
[ACUTE PAIN MANAGEMENT IN PATIENT ON OPIOID SUBSTITUTION THERAPY WITH\ METHADONE OR BUPRENORPHINE].
    Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti, 2016, Volume: 70, Issue:3

    Topics: Acute Disease; Buprenorphine; Humans; Methadone; Opiate Substitution Treatment; Pain; Pain Managemen

2016
Delta/mu opioid receptor interactions in operant conditioning assays of pain-depressed responding and drug-induced rate suppression: assessment of therapeutic index in male Sprague Dawley rats.
    Psychopharmacology, 2018, Volume: 235, Issue:5

    Topics: Analgesics, Opioid; Animals; Benzamides; Conditioning, Operant; Dose-Response Relationship, Drug; Ma

2018
Opioid Utilization by Pregnant Women with Sickle Cell Disease and the Risk of Neonatal Abstinence Syndrome.
    Journal of the National Medical Association, 2018, Volume: 110, Issue:2

    Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Case-Control Studies; Female; Humans; Incidence; Met

2018
Neurobiology of Opioid Use Disorder and Comorbid Traumatic Brain Injury.
    JAMA psychiatry, 2018, 06-01, Volume: 75, Issue:6

    Topics: Analgesics, Opioid; Brain Injuries, Traumatic; Buprenorphine; Humans; Methadone; Naltrexone; Opioid-

2018
Pain as a risk factor for substance use: a qualitative study of people who use drugs in British Columbia, Canada.
    Harm reduction journal, 2018, 07-05, Volume: 15, Issue:1

    Topics: Adult; Aged; Analgesics, Opioid; British Columbia; Female; Focus Groups; Harm Reduction; Health Serv

2018
Prevalence and Correlates of Loss of Control Eating among Adults Presenting for Methadone Maintenance Treatment.
    International journal of behavioral medicine, 2018, Volume: 25, Issue:6

    Topics: Adult; Comorbidity; Eating; Feeding and Eating Disorders; Female; Humans; Male; Methadone; Middle Ag

2018
Safe and Appropriate Use of Methadone in Hospice and Palliative Care: Expert Consensus White Paper.
    Journal of pain and symptom management, 2019, Volume: 57, Issue:3

    Topics: Analgesics, Opioid; Hospice Care; Humans; Methadone; Pain; Palliative Care

2019
Efficacy of low-dose and/or adjuvant methadone in palliative medicine.
    BMJ supportive & palliative care, 2022, Volume: 12, Issue:e6

    Topics: Humans; Methadone; Pain; Palliative Medicine; Randomized Controlled Trials as Topic; Retrospective S

2022
[A Case of Methadone Induced Drowsiness Following Trabectedin Induced Liver Injury].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2019, Volume: 46, Issue:7

    Topics: Aged; Chemical and Drug Induced Liver Injury; Histiocytoma, Malignant Fibrous; Humans; Liver; Male;

2019
The poor use of methadone in Italian hospices.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2013, Volume: 21, Issue:8

    Topics: Analgesics, Opioid; Attitude of Health Personnel; Data Collection; Home Care Services; Hospice Care;

2013
Very-high-dose methadone with minimal toxicity and inadequate pain control in a hospice patient with cancer.
    Journal of pain & palliative care pharmacotherapy, 2013, Volume: 27, Issue:2

    Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Hospice Care; Humans; Laryngeal Neoplasms; Mal

2013
How can a methadone and an opiate-positive immunoassay result be reconciled in a patient prescribed only OxyContin and Wellbutrin?
    Annals of clinical and laboratory science, 2013,Spring, Volume: 43, Issue:2

    Topics: Adult; Bupropion; Gas Chromatography-Mass Spectrometry; Humans; Immunoassay; Male; Methadone; Molecu

2013
Correlates of depressive symptoms among alcohol-using methadone maintained adults.
    The American journal on addictions, 2012, Volume: 21 Suppl 1

    Topics: Adult; Alcohol Drinking; Alcohol-Related Disorders; Analgesics, Opioid; Cross-Sectional Studies; Dep

2012
Enhanced antinociceptive efficacy of epidural compared with i.v. methadone in a rat model of thermal nociception.
    British journal of anaesthesia, 2014, Volume: 112, Issue:1

    Topics: Analgesics, Opioid; Animals; Epidural Space; Injections, Intravenous; Male; Methadone; Models, Anima

2014
Pain management discussion forum.
    Journal of pain & palliative care pharmacotherapy, 2013, Volume: 27, Issue:3

    Topics: Analgesics, Opioid; Hemophilia B; Humans; Male; Methadone; Opiate Substitution Treatment; Opioid-Rel

2013
Changes of QTc interval after opioid switching to oral methadone.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2013, Volume: 21, Issue:12

    Topics: Aged; Analgesics, Opioid; Electrocardiography; Female; Humans; Linear Models; Long QT Syndrome; Male

2013
Differential alternation of the antinociceptive effect of narcotic analgesics on the inflammatory pain state.
    Neuroscience letters, 2014, Feb-07, Volume: 560

    Topics: Animals; Fentanyl; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Methadone; Mice; Narcotics;

2014
Topical methadone: an alternative for pain control in end-of-life management.
    Journal of palliative medicine, 2014, Volume: 17, Issue:2

    Topics: Administration, Topical; Analgesics, Opioid; Drug Compounding; Humans; Methadone; Pain; Pain Managem

2014
Methadone for pain and the risk of adverse cardiac outcomes.
    Journal of pain and symptom management, 2014, Volume: 48, Issue:3

    Topics: Age Factors; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Heart Diseases; Humans; M

2014
What is your gut feeling about opioid rotation?
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015, Jan-20, Volume: 33, Issue:3

    Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Biological Availability; Delaye

2015
Methadone overdose and withdrawal in a tetraplegic patient: a case report.
    PM & R : the journal of injury, function, and rehabilitation, 2014, Volume: 6, Issue:8

    Topics: Adult; Analgesics, Opioid; Drug Overdose; Female; Humans; Methadone; Pain; Quadriplegia; Spinal Cord

2014
Informed consent abandoned--patient given contraindicated drug.
    Journal of the Medical Association of Georgia, 2014, Volume: 103, Issue:2

    Topics: Alcoholism; Contraindications; Depressive Disorder; Humans; Informed Consent; Male; Medication Recon

2014
My trauma patient takes methadone: how do I manage his pain?
    Journal of emergency nursing, 2014, Volume: 40, Issue:5

    Topics: Accidents, Traffic; Analgesics, Opioid; Emergency Service, Hospital; Humans; Male; Methadone; Pain;

2014
Methadone in combination with medetomidine as premedication prior to ovariohysterectomy and castration in the cat.
    Journal of feline medicine and surgery, 2015, Volume: 17, Issue:10

    Topics: Analgesia; Analgesics, Opioid; Anesthesia, General; Animals; Cat Diseases; Cats; Drug Therapy, Combi

2015
The use of very-low-dose methadone and haloperidol for pain control in the hospital setting: a preliminary report.
    Journal of palliative medicine, 2015, Volume: 18, Issue:2

    Topics: Administration, Oral; Aged; Aged, 80 and over; Analgesics, Opioid; California; Dose-Response Relatio

2015
HIV-gp120 and physical dependence to buprenorphine.
    Drug and alcohol dependence, 2015, May-01, Volume: 150

    Topics: Animals; Buprenorphine; HIV Envelope Protein gp120; HIV Infections; Male; Methadone; Opioid-Related

2015
Methadone for Pain: What to Do When the Oral Route Is Not Available.
    Journal of pain and symptom management, 2015, Volume: 49, Issue:6

    Topics: Administration, Rectal; Analgesics, Opioid; Fatal Outcome; Female; Humans; Methadone; Middle Aged; P

2015
Exposure to prescription opioid analgesics in utero and risk of neonatal abstinence syndrome: population based cohort study.
    BMJ (Clinical research ed.), 2015, May-14, Volume: 350

    Topics: Adolescent; Adult; Analgesics, Opioid; Cohort Studies; Dose-Response Relationship, Drug; Female; Hum

2015
Mediation of opioid analgesia by a truncated 6-transmembrane GPCR.
    The Journal of clinical investigation, 2015, Jul-01, Volume: 125, Issue:7

    Topics: Alternative Splicing; Analgesics, Opioid; Animals; Exons; Gene Targeting; Methadone; Mice; Mice, Kno

2015
Use of Very-Low-Dose Methadone and Haloperidol for Pain Control in Palliative Care Patients: Are the Sigma-1 Receptors Involved?
    Journal of palliative medicine, 2015, Volume: 18, Issue:8

    Topics: Analgesics, Opioid; Female; Haloperidol; Humans; Male; Methadone; Morphine; Pain; Pain Management; P

2015
Underestimated and unreported prolonged QTc by automated ECG analysis in patients on methadone: can we rely on computer reading?
    Acta cardiologica, 2015, Volume: 70, Issue:2

    Topics: Analgesics, Opioid; Diagnosis, Computer-Assisted; Diagnostic Errors; Electrocardiography; Female; Hu

2015
Methadone Recycling Sustains Drug Reservoir in Tissue.
    Journal of pain & palliative care pharmacotherapy, 2015, Volume: 29, Issue:3

    Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; H

2015
Methadone for Pain Relief.
    Journal of pain & palliative care pharmacotherapy, 2016, Volume: 30, Issue:2

    Topics: Analgesics, Opioid; Drug Interactions; Humans; Methadone; Pain

2016
Relationship between CYP2B6*6 and cold pressor pain sensitivity in opioid dependent patients on methadone maintenance therapy (MMT).
    Drug and alcohol dependence, 2016, Aug-01, Volume: 165

    Topics: Adult; Alleles; Analgesics, Opioid; Cytochrome P-450 CYP2B6; Genotype; Heterozygote; Humans; Male; M

2016
Trends in Methadone Distribution for Pain Treatment, Methadone Diversion, and Overdose Deaths - United States, 2002-2014.
    MMWR. Morbidity and mortality weekly report, 2016, Jul-08, Volume: 65, Issue:26

    Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Black or African American; Drug Overdose; Female; Hispa

2016
Methadone as a Coanalgesic for Palliative Care Cancer Patients.
    Journal of palliative medicine, 2016, Volume: 19, Issue:9

    Topics: Analgesics, Opioid; Humans; Methadone; Neoplasms; Pain; Palliative Care

2016
Methadone analgesia in the critically ill.
    Journal of critical care, 2016, Volume: 36

    Topics: Analgesia; Critical Illness; Humans; Methadone; Pain; Pain Management

2016
Letter response: Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer.
    European journal of cancer (Oxford, England : 1990), 2016, Volume: 68

    Topics: Analgesics, Opioid; Fentanyl; Head and Neck Neoplasms; Humans; Methadone; Neuralgia; Pain; Pain Meas

2016
Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer.
    European journal of cancer (Oxford, England : 1990), 2016, Volume: 68

    Topics: Analgesics, Opioid; Fentanyl; Head and Neck Neoplasms; Humans; Methadone; Neoplasms; Neuralgia; Pain

2016
Alternative analgesics: New drugs for pain seek to improve on ketamine's benefits.
    Nature medicine, 2017, 01-06, Volume: 23, Issue:1

    Topics: Analgesics, Non-Narcotic; Animals; Complex Regional Pain Syndromes; Drug Design; Fractures, Bone; Hu

2017
Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1.
    Molecular psychiatry, 2017, Volume: 22, Issue:3

    Topics: Adult; Alleles; Analgesics, Opioid; Black or African American; Dose-Response Relationship, Drug; Fem

2017
Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia.
    Brain, behavior, and immunity, 2008, Volume: 22, Issue:8

    Topics: Analgesia; Analgesics, Opioid; Animals; Catheters, Indwelling; Chemokine CX3CL1; Cytokines; Hyperalg

2008
Opioid-induced pain.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Jul-10, Volume: 26, Issue:20

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans;

2008
Methadone: a closer look at the controversy.
    Journal of pain and symptom management, 2008, Volume: 36, Issue:2

    Topics: Analgesics, Opioid; Humans; Methadone; Opioid-Related Disorders; Pain; Palliative Care

2008
Management of acute pain in methadone maintenance therapy in-patients.
    Drug and alcohol review, 2008, Volume: 27, Issue:5

    Topics: Acute Disease; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Australia; Dose-Response Relatio

2008
Methadone analgesia for persistent pain: safety and toxicity considerations.
    Medicine and health, Rhode Island, 2008, Volume: 91, Issue:9

    Topics: Analgesics, Opioid; Chronic Disease; Drug Interactions; Humans; Methadone; Pain

2008
Methadone in internal medicine.
    Annals of the New York Academy of Sciences, 1948, Nov-01, Volume: 51, Issue:Art 1

    Topics: Analgesia; Analgesics; Humans; Internal Medicine; Methadone; Pain; Pain Management

1948
The use of dolophine (dimethylamino heptanone-methadon) in the control of pain in bone and joint disorders.
    The Journal of the Oklahoma State Medical Association, 1947, Volume: 40, Issue:11

    Topics: Bone Diseases; Humans; Joint Diseases; Methadone; Pain

1947
[Analgesics and palliative care].
    Revue medicale de Bruxelles, 2008, Volume: 29, Issue:4

    Topics: Analgesics; Analgesics, Opioid; Fentanyl; Humans; Methadone; Morphine; Neoplasms; Pain; Palliative C

2008
Alleged breaches of "standards of medical care" in a patient overdose death possibly related to chronic opioid analgesic therapy, application of the controlled substances model guidelines: case report.
    Pain medicine (Malden, Mass.), 2009, Volume: 10, Issue:3

    Topics: Adult; Analgesics, Opioid; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Diazepam; Doxepin;

2009
Urine drug testing of chronic pain patients: licit and illicit drug patterns.
    Journal of analytical toxicology, 2008, Volume: 32, Issue:8

    Topics: Amphetamines; Analgesics, Opioid; Benzodiazepines; Cannabinoids; Carisoprodol; Chronic Disease; Huma

2008
Treating opioid dependency and coexistent chronic nonmalignant pain.
    American family physician, 2008, Nov-15, Volume: 78, Issue:10

    Topics: Analgesics, Opioid; Buprenorphine; Chronic Disease; Humans; Methadone; Opioid-Related Disorders; Pai

2008
Conversion from parenteral to oral methadone.
    Journal of pain & palliative care pharmacotherapy, 2008, Volume: 22, Issue:3

    Topics: Administration, Oral; Aged; Aged, 80 and over; Analgesics, Opioid; Biological Availability; Dose-Res

2008
European pain management discussion forum.
    Journal of pain & palliative care pharmacotherapy, 2008, Volume: 22, Issue:3

    Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Europe; Herpes Zoster; Humans; Methadone; Morphine; Neural

2008
Hyperalgesia in opioid-managed chronic pain and opioid-dependent patients.
    The journal of pain, 2009, Volume: 10, Issue:3

    Topics: Adult; Analgesics, Opioid; Chronic Disease; Drug Tolerance; Female; Humans; Hyperalgesia; Male; Meth

2009
Providers' experiences treating chronic pain among opioid-dependent drug users.
    Journal of general internal medicine, 2009, Volume: 24, Issue:4

    Topics: Chronic Disease; Decision Making; Delivery of Health Care, Integrated; Humans; Methadone; Opioid-Rel

2009
Methadone: an effective, safe drug of first choice for pain management in frail older adults.
    Pain medicine (Malden, Mass.), 2009, Volume: 10, Issue:2

    Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Disease; Female; Frail Elderly; Homes for the A

2009
Self-efficacy and depression as mediators of the relationship between pain and antiretroviral adherence.
    AIDS care, 2009, Volume: 21, Issue:2

    Topics: Adolescent; Adult; Aged; Anti-HIV Agents; Depressive Disorder; Female; HIV Infections; Humans; Male;

2009
Interaction between rifampicin and methadone.
    Acta anaesthesiologica Scandinavica, 2009, Volume: 53, Issue:3

    Topics: Drug Interactions; Humans; Methadone; Pain; Rifampin

2009
Methadone for chronic pain in older adults: blast from the past but are we ready for it to return to prime time?
    Pain medicine (Malden, Mass.), 2009, Volume: 10, Issue:2

    Topics: Adult; Aged; Analgesics, Opioid; Chronic Disease; Humans; Methadone; Pain

2009
Methadone antinociception is dependent on peripheral opioid receptors.
    The journal of pain, 2009, Volume: 10, Issue:4

    Topics: Analgesics, Opioid; Animals; Drug Administration Routes; Injections, Intraventricular; Injections, S

2009
Frequency, indications, outcomes, and predictive factors of opioid switching in an acute palliative care unit.
    Journal of pain and symptom management, 2009, Volume: 37, Issue:4

    Topics: Adult; Aged; Analgesics, Opioid; Buprenorphine; Female; Fentanyl; Humans; Male; Methadone; Middle Ag

2009
Documented poor sleep among methadone-maintained patients is associated with chronic pain and benzodiazepine abuse, but not with methadone dose.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2009, Volume: 19, Issue:8

    Topics: Adult; Benzodiazepines; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Male; Met

2009
Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy.
    The American journal of drug and alcohol abuse, 2009, Volume: 35, Issue:3

    Topics: Acute Disease; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Buprenorphine; Controlled Clinic

2009
Methadone for pain: limited evidence, tenuous guidelines.
    The journal of pain, 2009, Volume: 10, Issue:7

    Topics: Analgesics, Opioid; Humans; Methadone; Pain; Practice Guidelines as Topic

2009
Use of epidurally derived evoked potentials for quantification of caudal nociception in ponies.
    American journal of veterinary research, 2009, Volume: 70, Issue:7

    Topics: Analgesics, Opioid; Animals; Electric Stimulation; Electromyography; Evoked Potentials, Somatosensor

2009
Relations among psychopathology, substance use, and physical pain experiences in methadone-maintained patients.
    The Journal of clinical psychiatry, 2009, Volume: 70, Issue:9

    Topics: Adult; Chronic Disease; Comorbidity; Connecticut; Female; Humans; Male; Mental Disorders; Methadone;

2009
Efficacy of oral sucrose in infants of methadone-maintained mothers.
    Neonatology, 2010, Volume: 97, Issue:1

    Topics: Administration, Oral; Adult; Analgesia; Analgesics; Blood Specimen Collection; Female; Gestational A

2010
Exploring the relationship between perceived inter-dose opioid withdrawal and patient characteristics in methadone maintenance treatment.
    Drug and alcohol dependence, 2009, Dec-01, Volume: 105, Issue:3

    Topics: Adult; Affect; Anxiety; Behavior, Addictive; Female; Humans; Male; Methadone; Opioid-Related Disorde

2009
Chronic pain: levorphanol, methadone, and the N-methyl-D-aspartate receptor.
    Journal of palliative medicine, 2009, Volume: 12, Issue:9

    Topics: Analgesics, Opioid; Chronic Disease; Hospice Care; Humans; Levorphanol; Methadone; N-Methylaspartate

2009
Quantification of a methadone metabolite (EDDP) in urine: assessment of compliance.
    Clinical medicine & research, 2009, Volume: 7, Issue:4

    Topics: Analgesics, Opioid; Chronic Disease; Creatinine; Female; Follow-Up Studies; Humans; Male; Methadone;

2009
Methadone initiation and rotation in the outpatient setting for patients with cancer pain.
    Cancer, 2010, Jan-15, Volume: 116, Issue:2

    Topics: Ambulatory Care; Analgesics, Opioid; Drug Administration Schedule; Female; Humans; Male; Methadone;

2010
Treatment of acute pain in opioid tolerant patients.
    Connecticut medicine, 2010, Volume: 74, Issue:3

    Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Drug Tolerance; Humans;

2010
[Displaced pain pump because of a pendulous abdomen - dermatolipectomy as solution of the problem].
    Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V..., 2010, Volume: 42, Issue:4

    Topics: Abdominal Fat; Adult; Amides; Analgesics, Opioid; Chronic Disease; Equipment Failure Analysis; Femal

2010
Methadone deaths in pain and addiction populations.
    Journal of general internal medicine, 2010, Volume: 25, Issue:9

    Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Pain; Palliative Care; Substance-Related Dis

2010
Post-marketing surveillance of methadone and buprenorphine in the United States.
    Pain medicine (Malden, Mass.), 2010, Volume: 11, Issue:7

    Topics: Analgesics, Opioid; Buprenorphine; Data Collection; Humans; Marketing; Methadone; Opioid-Related Dis

2010
The differential effect of methadone dose and of chronic pain on pain perception of former heroin addicts receiving methadone maintenance treatment.
    The journal of pain, 2011, Volume: 12, Issue:1

    Topics: Adult; Analgesics, Opioid; Analysis of Variance; Chronic Disease; Dose-Response Relationship, Drug;

2011
Exploring relations among traumatic, posttraumatic, and physical pain experiences in methadone-maintained patients.
    The journal of pain, 2011, Volume: 12, Issue:1

    Topics: Adult; Analgesics, Opioid; Cross-Sectional Studies; Female; Humans; Life Change Events; Male; Methad

2011
A formal feasibility study of sublingual methadone for breakthrough cancer pain.
    Palliative medicine, 2010, Volume: 24, Issue:7

    Topics: Administration, Sublingual; Adult; Aged; Aged, 80 and over; Alberta; Analgesics, Opioid; Drug Monito

2010
The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics.
    Neuropharmacology, 2011, Volume: 60, Issue:1

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Arrestins; beta-Arrestins; Drug Tolerance; Fentan

2011
Self-reported side effects in buprenorphine and methadone patients receiving antiretroviral therapy: results from the MANIF 2000 cohort study.
    Addiction (Abingdon, England), 2010, Volume: 105, Issue:12

    Topics: Anti-Retroviral Agents; Attitude to Health; Buprenorphine; Cohort Studies; Depression; Female; Franc

2010
Injection-related venous disease and walking mobility.
    Journal of addictive diseases, 2010, Volume: 29, Issue:4

    Topics: Adult; Aged; Chronic Disease; Cross-Sectional Studies; Female; Humans; Illicit Drugs; Leg Injuries;

2010
Use of methadone for uncontrolled pain: an alternative dosing regimen.
    Journal of pain and symptom management, 2010, Volume: 40, Issue:6

    Topics: Analgesics, Opioid; Drug Administration Schedule; Humans; Methadone; Pain; Treatment Outcome

2010
The methadone epidemic: methadone-related deaths on the rise in Vermont.
    The American journal of forensic medicine and pathology, 2011, Volume: 32, Issue:2

    Topics: Accidents; Adolescent; Adult; Age Distribution; Aged; Central Nervous System Depressants; Crime; Dru

2011
Pain catastrophizing and pain coping among methadone-maintained patients.
    Pain medicine (Malden, Mass.), 2011, Volume: 12, Issue:1

    Topics: Adaptation, Psychological; Adult; Catastrophization; Depression; Disability Evaluation; Employment;

2011
Painkillers fuel growth in drug addiction. Opioid overdoses now kill more people than cocaine or heroin.
    The Harvard mental health letter, 2011, Volume: 27, Issue:7

    Topics: Analgesics, Opioid; Buprenorphine; Cocaine; Drug Overdose; Drug Prescriptions; Health Knowledge, Att

2011
Evaluation of methadone absorption after topical administration to hospice patients.
    Journal of pain and symptom management, 2011, Volume: 41, Issue:5

    Topics: Administration, Oral; Administration, Topical; Aged; Aged, 80 and over; Analgesics, Opioid; Female;

2011
Effects of the delta-opioid agonist SNC80 on the abuse liability of methadone in rhesus monkeys: a behavioral economic analysis.
    Psychopharmacology, 2011, Volume: 216, Issue:3

    Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Cocaine; Data Interpretation, Statistic

2011
Choosing the unit of measurement counts: the use of oral morphine equivalents in studies of opioid consumption is a useful addition to defined daily doses.
    Palliative medicine, 2011, Volume: 25, Issue:7

    Topics: Administration, Oral; Analgesics, Opioid; Cooperative Behavior; Databases, Factual; Drug Utilization

2011
Comparative mortality among Department of Veterans Affairs patients prescribed methadone or long-acting morphine for chronic pain.
    Pain, 2011, Volume: 152, Issue:8

    Topics: Adult; Aged; Analgesics, Opioid; Benzodiazepines; Cohort Studies; Drug Delivery Systems; Female; Hum

2011
Methadone: friend or foe?
    Tennessee medicine : journal of the Tennessee Medical Association, 2011, Volume: 104, Issue:4

    Topics: Analgesics, Opioid; Drug Dosage Calculations; Drug Monitoring; Drug Substitution; Humans; Methadone;

2011
Differential antinociceptive effects of buprenorphine and methadone in the presence of HIV-gp120.
    Drug and alcohol dependence, 2011, Nov-01, Volume: 118, Issue:2-3

    Topics: Analgesia; Analgesics, Opioid; Animals; Buprenorphine; HIV Envelope Protein gp120; Hot Temperature;

2011
Neostigmine for the treatment of gastrointestinal atony: a report of one case.
    Journal of palliative medicine, 2011, Volume: 14, Issue:11

    Topics: Aged; Analgesics, Opioid; Constipation; Female; Humans; Injections, Subcutaneous; Methadone; Neoplas

2011
An analysis of the root causes for opioid-related overdose deaths in the United States.
    Pain medicine (Malden, Mass.), 2011, Volume: 12 Suppl 2

    Topics: Analgesics, Opioid; Comorbidity; Databases, Factual; Drug Overdose; Humans; Medication Errors; Metha

2011
Opioid switching to methadone: a pharmacoepidemiological study from a national prescription database.
    Palliative medicine, 2012, Volume: 26, Issue:6

    Topics: Adult; Aged; Analgesics, Opioid; Databases, Factual; Drug Prescriptions; Drug Substitution; Humans;

2012
THC-methadone and THC-naltrexone interactions on discrimination, antinociception, and locomotion in rats.
    Behavioural pharmacology, 2011, Volume: 22, Issue:5-6

    Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Discrimination Learning; Disease Models, Anim

2011
The effect of pain on stroop performance in patients with opiate dependence in sustained remission.
    Journal of addiction medicine, 2011, Volume: 5, Issue:1

    Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Pain; Pain

2011
Use of methadone as a coanalgesic.
    Journal of pain and symptom management, 2011, Volume: 42, Issue:6

    Topics: Analgesics, Opioid; Humans; Methadone; Pain

2011
Gabapentin as part of multi-modal analgesia in two cats suffering multiple injuries.
    Veterinary anaesthesia and analgesia, 2011, Volume: 38, Issue:5

    Topics: Amines; Analgesia; Analgesics; Animals; Buprenorphine; Cat Diseases; Cats; Cyclohexanecarboxylic Aci

2011
Characterization of the antinociceptive effects of the individual isomers of methadone after acute and chronic administrations.
    Behavioural pharmacology, 2011, Volume: 22, Issue:5-6

    Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administ

2011
Is it time to reformulate racemic methadone?
    Journal of addiction medicine, 2011, Volume: 5, Issue:3

    Topics: Adult; Arrhythmias, Cardiac; Chemistry, Pharmaceutical; Chronic Disease; Death, Sudden, Cardiac; Fem

2011
Switching from oxycodone to methadone in advanced cancer patients.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2012, Volume: 20, Issue:1

    Topics: Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Humans; Male; Methadone; Middle

2012
Inconsistencies in opioid equianalgesic ratios: clinical and research implications.
    Journal of pain & palliative care pharmacotherapy, 2008, Volume: 22, Issue:4

    Topics: Administration, Cutaneous; Administration, Oral; Adult; Analgesics, Opioid; Delayed-Action Preparati

2008
Chronic methadone treatment shows a better cost/benefit ratio than chronic morphine in mice.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:2

    Topics: Analgesics, Opioid; Animals; Area Under Curve; Dose-Response Relationship, Drug; Drug Tolerance; End

2012
Transitioning a cancer patient from high-dose intravenous hydromorphone therapy to intravenous methadone.
    Journal of pain & palliative care pharmacotherapy, 2011, Volume: 25, Issue:4

    Topics: Adult; Analgesics, Opioid; Colorectal Neoplasms; Fatal Outcome; Female; Humans; Hydromorphone; Infus

2011
Practicability, safety, and efficacy of a "German model" for opioid conversion to oral levo-methadone.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2012, Volume: 20, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Substitut

2012
Stop and go strategy for opioid switching requires flexibility.
    European journal of cancer (Oxford, England : 1990), 2012, Volume: 48, Issue:6

    Topics: Analgesics, Opioid; Drug Substitution; Female; Humans; Male; Methadone; Morphine; Neoplasms; Oxycodo

2012
Switching methadone: a 10-year experience of 345 patients in an acute palliative care unit.
    Pain medicine (Malden, Mass.), 2012, Volume: 13, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Female; Humans; Male; Methadone; Middle Aged; Ne

2012
Severe central sleep apnea in a child with leukemia on chronic methadone therapy.
    Pediatric pulmonology, 2013, Volume: 48, Issue:1

    Topics: Analgesics, Opioid; Child; Humans; Leukemia, Myeloid, Acute; Male; Methadone; Pain; Severity of Illn

2013
Use of methadone as a coanalgesic: response to McKenna and Nicholson.
    Journal of pain and symptom management, 2012, Volume: 43, Issue:4

    Topics: Analgesics, Opioid; Humans; Methadone; Pain

2012
The disparate treatment of medications and opiate pain medications under the law: permitting the proliferation of opiates and limiting access to treatment.
    Seton Hall law review, 2012, Volume: 42, Issue:2

    Topics: Analgesics, Opioid; Buprenorphine; Drug and Narcotic Control; Drug Approval; Health Services Accessi

2012
Methadone in combination with acepromazine as premedication prior to neutering in the cat.
    Veterinary anaesthesia and analgesia, 2013, Volume: 40, Issue:2

    Topics: Acepromazine; Analgesics, Opioid; Anesthesia, General; Animals; Behavior, Animal; Buprenorphine; But

2013
Pain depression and sleep disorders among methadone maintenance treatment patients.
    Addictive behaviors, 2012, Volume: 37, Issue:11

    Topics: Adult; Analysis of Variance; Depressive Disorder; Female; Health Status; Humans; Male; Mental Health

2012
Vital signs: risk for overdose from methadone used for pain relief - United States, 1999-2010.
    MMWR. Morbidity and mortality weekly report, 2012, Jul-06, Volume: 61, Issue:26

    Topics: Analgesics, Opioid; Drug Overdose; Guideline Adherence; Humans; Methadone; Pain; Practice Patterns,

2012
Switching from methadone to tapentadol for cancer pain.
    Journal of pain and symptom management, 2012, Volume: 44, Issue:3

    Topics: Aged; Analgesics, Opioid; Female; Humans; Methadone; Multiple Myeloma; Neoplasms; Pain; Phenols; Tap

2012
Methadone overdose deaths rise with increased prescribing for pain.
    JAMA, 2012, Aug-22, Volume: 308, Issue:8

    Topics: Analgesics, Opioid; Drug Costs; Drug Overdose; Formularies as Topic; Humans; Medicaid; Methadone; Mo

2012
Prescription patterns of pain medicine physicians.
    Pain practice : the official journal of World Institute of Pain, 2013, Volume: 13, Issue:6

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Drug Prescriptions; Humans; Methadone; Opioid-Related

2013
Addition of methadone to another opioid in the management of moderate to severe cancer pain: a case series.
    Journal of palliative medicine, 2013, Volume: 16, Issue:3

    Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Female; Humans; Male; Methadone; Middle Aged; Neoplasms

2013
Successful use of oral methadone after failure of intravenous morphine and ketamine.
    Anaesthesia and intensive care, 2002, Volume: 30, Issue:4

    Topics: Acute Disease; Administration, Oral; Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, O

2002
Torsade de pointes associated with very-high-dose methadone.
    Annals of internal medicine, 2002, Sep-17, Volume: 137, Issue:6

    Topics: Adult; Analgesics, Opioid; Canada; Chronic Disease; Electrocardiography; Female; Heroin Dependence;

2002
Summaries for patients. Very high doses of methadone may cause abnormal heart rhythm.
    Annals of internal medicine, 2002, Sep-17, Volume: 137, Issue:6

    Topics: Adult; Analgesics, Opioid; Canada; Chronic Disease; Female; Heroin Dependence; Humans; Male; Methado

2002
Therapy of chronic non-malignant pain with opioids.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2003, Volume: 50, Issue:1

    Topics: Analgesics, Opioid; Humans; Methadone; Middle Aged; Pain; Tramadol

2003
An ad libitum schedule for conversion of morphine to methadone in advanced cancer patients: an open uncontrolled prospective study in a Chinese population.
    Palliative medicine, 2003, Volume: 17, Issue:2

    Topics: Administration, Oral; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; China; Drug Ad

2003
Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities.
    JAMA, 2003, May-14, Volume: 289, Issue:18

    Topics: Adult; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; Middle Aged; Multivaria

2003
Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities.
    JAMA, 2003, May-14, Volume: 289, Issue:18

    Topics: Adult; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; Middle Aged; Multivaria

2003
Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities.
    JAMA, 2003, May-14, Volume: 289, Issue:18

    Topics: Adult; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; Middle Aged; Multivaria

2003
Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities.
    JAMA, 2003, May-14, Volume: 289, Issue:18

    Topics: Adult; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; Middle Aged; Multivaria

2003
Ultra-low dose oral naltrexone decreases side effects and potentiates the effect of methadone.
    Journal of pain and symptom management, 2003, Volume: 25, Issue:6

    Topics: Administration, Oral; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Interactions; Human

2003
High dose methadone and ventricular arrhythmias: a report of three cases.
    Pain, 2003, Volume: 103, Issue:3

    Topics: Administration, Oral; Adult; Analgesics, Opioid; Arrhythmias, Cardiac; Drug Interactions; Heart Vent

2003
Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes.
    Pharmacotherapy, 2003, Volume: 23, Issue:6

    Topics: Adult; Aged; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Hypokalemia; Lon

2003
The trend to move palliative care upstream.
    Journal of palliative medicine, 2003, Volume: 6, Issue:2

    Topics: Acetates; Adult; Amines; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; H

2003
Pain management by a new series of dual inhibitors of enkephalin degrading enzymes: long lasting antinociceptive properties and potentiation by CCK2 antagonist or methadone.
    Pain, 2003, Volume: 104, Issue:1-2

    Topics: Aminopeptidases; Analgesics; Animals; Disease Management; Dose-Response Relationship, Drug; Drug Syn

2003
Medico-legal rounds: medico-legal issues and alleged breaches of "standards of medical care" in opioid rotation to methadone: a case report.
    Pain medicine (Malden, Mass.), 2003, Volume: 4, Issue:2

    Topics: Adult; Analgesics, Opioid; Autopsy; Chronic Disease; Decision Making; Expert Testimony; Florida; Hum

2003
Parenteral methadone: an essential medication for the treatment of pain.
    Journal of pain and symptom management, 2003, Volume: 26, Issue:2

    Topics: Analgesics, Opioid; Humans; Infusions, Parenteral; Methadone; Pain

2003
Methadone and the hospice patient: prescribing trends in the home-care setting.
    Pain medicine (Malden, Mass.), 2003, Volume: 4, Issue:3

    Topics: Analgesics, Opioid; Drug Prescriptions; Drug Utilization; Female; Home Care Services; Hospice Care;

2003
Drug addiction and other considerations in the management of pain with narcotic drugs.
    Proceedings of the staff meetings. Mayo Clinic, 1957, Feb-06, Volume: 32, Issue:3

    Topics: Behavior, Addictive; Humans; Meperidine; Methadone; Morphine Dependence; Morphine Derivatives; Narco

1957
Drug addiction and other considerations in the management of pain with narcotic drugs.
    Proceedings of the staff meetings. Mayo Clinic, 1957, Feb-06, Volume: 32, Issue:3

    Topics: Behavior, Addictive; Humans; Meperidine; Methadone; Morphine Dependence; Morphine Derivatives; Narco

1957
Drug addiction and other considerations in the management of pain with narcotic drugs.
    Proceedings of the staff meetings. Mayo Clinic, 1957, Feb-06, Volume: 32, Issue:3

    Topics: Behavior, Addictive; Humans; Meperidine; Methadone; Morphine Dependence; Morphine Derivatives; Narco

1957
Drug addiction and other considerations in the management of pain with narcotic drugs.
    Proceedings of the staff meetings. Mayo Clinic, 1957, Feb-06, Volume: 32, Issue:3

    Topics: Behavior, Addictive; Humans; Meperidine; Methadone; Morphine Dependence; Morphine Derivatives; Narco

1957
Analgesic activity of dipipanone hydrochloride in student volunteers.
    British journal of pharmacology and chemotherapy, 1957, Volume: 12, Issue:1

    Topics: Analgesics; Humans; Methadone; Pain; Pain Threshold; Students; Volunteers

1957
Comparative effects of analgesics on pain threshold, respiratory frequency and gastrointestinal propulsion.
    British journal of pharmacology and chemotherapy, 1959, Volume: 14, Issue:1

    Topics: Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Antipyretics; Cell Respiration; C

1959
Analgesia in electromyography.
    Archives of physical medicine and rehabilitation, 1963, Volume: 44

    Topics: Analgesia; Electromyography; Humans; Meperidine; Methadone; Pain; Pain Management; Promethazine

1963
DOUBLE BLIND TRIAL OF DEXTROMORAMIDE, METHADONE AND PETHIDINE IN THE TREATMENT OF SEVERE PAIN.
    Postgraduate medical journal, 1964, Volume: 40

    Topics: Dextromoramide; Double-Blind Method; Humans; Meperidine; Methadone; Pain; Toxicology

1964
ANALGESICS FOR THE RELIEF OF PAIN. I. NARCOTIC ANALGESICS.
    Wisconsin medical journal, 1964, Volume: 63

    Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Codeine; Humans; Hydromorphone; Meperidine; Meth

1964
A CLINICAL TRIAL OF A MIXTURE OF LEVORPHANOL AND LEVALLORPHAN AS AN ORAL ANALEGESIC.
    British journal of anaesthesia, 1964, Volume: 36

    Topics: Drug Therapy; Humans; Levallorphan; Levorphanol; Methadone; Neoplasms; Osteoarthritis; Pain; Substan

1964
THE IMPORTANCE OF STERIC CONFIGUA. ION IN CERTAIN MORPHINNE-MIMETIC ACTIONS OF SYNTHETIC ANALGETICS.
    The Journal of pharmacology and experimental therapeutics, 1964, Volume: 145

    Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Apnea; Chemical Phenomena; Chemistry; Methadone;

1964
[ANALGESIA FOLLOWING GYNECOLOGICAL OPERATIONS].
    Die Medizinische Welt, 1965, Feb-06, Volume: 14

    Topics: Analgesia; Drug Therapy; Female; Genital Diseases, Female; Humans; Meperidine; Methadone; Pain; Phen

1965
[Analgetic effect of morphine, dolsin and mecodin in various ways of application; a pharmacological study].
    Ceskoslovenska farmacie, 1955, Volume: 4, Issue:3

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Meperidine; Methadone; Morphine; Pain; Pain Managem

1955
QTc interval prolongation associated with intravenous methadone.
    Pain, 2003, Volume: 105, Issue:3

    Topics: Cell Line; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Infusions, Intrave

2003
Methadone maintenance therapy and chronic pain.
    JAMA, 2003, Nov-12, Volume: 290, Issue:18

    Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Pain; Substance Abuse Treatment Centers; Sub

2003
Use of methadone for neuropathic pain.
    Pain research & management, 2003,Fall, Volume: 8, Issue:3

    Topics: Clinical Trials as Topic; Humans; Methadone; Pain

2003
Treatment needs associated with pain in substance use disorder patients: implications for concurrent treatment.
    Drug and alcohol dependence, 2004, Jan-07, Volume: 73, Issue:1

    Topics: Adult; Analgesics, Opioid; Analysis of Variance; Chronic Disease; Comorbidity; Cross-Sectional Studi

2004
Outcomes of infants born to mothers receiving methadone for pain management in pregnancy.
    Archives of disease in childhood. Fetal and neonatal edition, 2004, Volume: 89, Issue:1

    Topics: Analgesics, Opioid; Chronic Disease; Delivery, Obstetric; Drug Administration Schedule; Female; Gest

2004
Prescription opioid abuse in patients presenting for methadone maintenance treatment.
    Drug and alcohol dependence, 2004, Feb-07, Volume: 73, Issue:2

    Topics: Adult; Comorbidity; Drug Prescriptions; Female; Humans; Male; Mental Disorders; Methadone; Narcotics

2004
Opioid therapy in patients with a history of substance abuse.
    CNS drugs, 2004, Volume: 18, Issue:1

    Topics: Chronic Disease; Drug Administration Schedule; Drug Tolerance; Humans; Medical History Taking; Metha

2004
A comparison of heat and pressure analgesiometric methods in rats.
    British journal of pharmacology and chemotherapy, 1951, Volume: 6, Issue:4

    Topics: Animals; Hot Temperature; Methadone; Morphine; Pain; Pressure; Rats

1951
Switching to methadone: 'ad libitum' or fixed dose ratio?
    Palliative medicine, 2004, Volume: 18, Issue:1

    Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Morphine; Neoplasms; Pain; Patient Satisfact

2004
Sleep disturbances among methadone maintained patients.
    Journal of substance abuse treatment, 2004, Volume: 26, Issue:3

    Topics: Adult; Alcohol Drinking; Female; Humans; Least-Squares Analysis; Male; Methadone; Opioid-Related Dis

2004
Of "blind dosing" and detoxification: justifiable or ill conceived?
    Pain medicine (Malden, Mass.), 2001, Volume: 2, Issue:3

    Topics: Adult; Analgesics, Opioid; Deception; Disclosure; Heroin Dependence; Humans; Informed Consent; Male;

2001
Methadone for pain: No. 75.
    Journal of palliative medicine, 2004, Volume: 7, Issue:2

    Topics: Administration, Oral; Analgesics, Opioid; Humans; Methadone; Pain; Palliative Care

2004
Methadone: starting dosing information No. 86.
    Journal of palliative medicine, 2004, Volume: 7, Issue:2

    Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Humans; Methadone; Pain; Palliative Care; Prac

2004
(S)-(+)-methadone is more immunosuppressive than the potent analgesic (R)-(--)-methadone.
    International immunopharmacology, 2004, Volume: 4, Issue:12

    Topics: Analgesics, Opioid; Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Immunosupp

2004
[Polamidon as a spasmolytic and analgesic].
    Medizinische Klinik, 1950, Apr-21, Volume: 45, Issue:16

    Topics: Analgesics; Humans; Methadone; Morphine; Pain; Parasympatholytics; Spasm

1950
Oral methadone for cancer pain: no indication of Q-T interval prolongation or torsades de pointes.
    Journal of pain and symptom management, 2004, Volume: 28, Issue:4

    Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Electrocardiography; Heart Rate; Humans; Methadone; Neopla

2004
The experience of chronic severe pain in patients undergoing methadone maintenance treatment.
    Journal of pain and symptom management, 2004, Volume: 28, Issue:5

    Topics: Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; Middle Aged; Pain; Self Care;

2004
Successful treatment of hydromorphone-induced neurotoxicity and hyperalgesia.
    Connecticut medicine, 2004, Volume: 68, Issue:9

    Topics: Humans; Hydromorphone; Hyperalgesia; Male; Methadone; Middle Aged; Narcotics; Neurotoxicity Syndrome

2004
Diversion and abuse of methadone prescribed for pain management.
    JAMA, 2005, Jan-19, Volume: 293, Issue:3

    Topics: Analgesics, Opioid; Drug and Narcotic Control; Drug Prescriptions; Humans; Methadone; Opioid-Related

2005
Profound morphine tolerance following high-dose methadone therapy.
    Journal of pain & palliative care pharmacotherapy, 2004, Volume: 18, Issue:4

    Topics: Analgesics; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Male; Methadone; Middle Aged;

2004
Methadone-related Torsades de Pointes in a sickle cell patient treated for chronic pain.
    American journal of hematology, 2005, Volume: 78, Issue:4

    Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Male; Methadone; Pain; Torsades de Pointes

2005
[Oral pain and loss of teeth in a 36-year-old woman].
    Enfermedades infecciosas y microbiologia clinica, 2005, Volume: 23, Issue:4

    Topics: Adult; Anti-Bacterial Agents; Antiretroviral Therapy, Highly Active; Combined Modality Therapy; Debr

2005
Opioid rotation from methadone: fraught with difficulties.
    Journal of pain and symptom management, 2005, Volume: 29, Issue:4

    Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Live

2005
Torsades de pointes with methadone.
    Prescrire international, 2005, Volume: 14, Issue:76

    Topics: Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Drug Interactions; Heroin; Humans; Hypokalemia; L

2005
Methadone treatment of chronic non-malignant pain and opioid dependence--a long-term follow-up.
    European journal of pain (London, England), 2006, Volume: 10, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Chronic Disease; Drug Administration Schedule; Female; Follow-Up St

2006
Comparative actions of the opioid analgesics morphine, methadone and codeine in rat models of peripheral and central neuropathic pain.
    Pain, 2005, Volume: 116, Issue:3

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Codeine; Disease Models, Animal; Male; Methadone; Mor

2005
Effects of N-methyl-D-aspartate receptor antagonists on acute morphine-induced and l-methadone-induced antinociception in mice.
    The journal of pain, 2005, Volume: 6, Issue:7

    Topics: Analgesia; Analgesics, Opioid; Animals; Central Nervous System; Dose-Response Relationship, Drug; Dr

2005
Dextromethorphan-induced delirium and possible methadone interaction.
    The American journal of geriatric pharmacotherapy, 2005, Volume: 3, Issue:1

    Topics: Aged; Analgesics, Opioid; Antitussive Agents; Cough; Delirium; Depressive Disorder; Dextromethorphan

2005
Response to methadone maintenance treatment of opiate dependent patients with and without significant pain.
    Drug and alcohol dependence, 2006, May-20, Volume: 82, Issue:3

    Topics: Adult; Analgesics, Opioid; Female; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders; P

2006
Methadone for neuropathic pain: a new use for an old drug?
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2005, Volume: 32, Issue:3

    Topics: Analgesics, Opioid; Excitatory Amino Acid Antagonists; Humans; Methadone; Pain; Peripheral Nervous S

2005
Prescribing methadone as an analgesic.
    Annals of internal medicine, 2005, Oct-18, Volume: 143, Issue:8

    Topics: Analgesics; Chronic Disease; Drug Administration Schedule; Half-Life; Humans; Methadone; Pain

2005
Methadone--an old analgesic with new tricks.
    Pain research & management, 2005,Autumn, Volume: 10, Issue:3

    Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Pain

2005
Methadone titration: still no gauge on the tank.
    Palliative medicine, 2005, Volume: 19, Issue:7

    Topics: Analgesics, Opioid; Carcinoma, Small Cell; Drug Administration Schedule; Humans; Lung Neoplasms; Mal

2005
Methadone: a double edged sword.
    Journal of pain & palliative care pharmacotherapy, 2005, Volume: 19, Issue:4

    Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Pain

2005
Opioid switching from oral slow release morphine to oral methadone may improve pain control in chronic non-malignant pain: a nine-month follow-up study.
    Palliative medicine, 2006, Volume: 20, Issue:1

    Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Chronic Disease; Delayed-Action Preparations;

2006
Response phases in methadone treatment for chronic nonmalignant pain.
    Pain management nursing : official journal of the American Society of Pain Management Nurses, 2006, Volume: 7, Issue:1

    Topics: Adaptation, Psychological; Adult; Analgesics, Opioid; Causality; Chronic Disease; Family; Female; He

2006
Prescription drug dependence and evolving beliefs about chronic pain management.
    The American journal of psychiatry, 2006, Volume: 163, Issue:4

    Topics: Adult; Analgesics, Opioid; Chronic Disease; Drug Prescriptions; Drug Tolerance; Drug Utilization; Fe

2006
ME Lynch. A review of the use of methadone for the treatment of chronic noncancer pain. Pain Res Manage 2005;10(3):133-44.
    Pain research & management, 2006,Spring, Volume: 11, Issue:1

    Topics: Analgesics, Opioid; Drug Therapy, Combination; Humans; Methadone; Pain

2006
Rotating methadone to other opioids: a lesson in the mechanisms of opioid tolerance and opioid-induced pain.
    Journal of palliative medicine, 2006, Volume: 9, Issue:2

    Topics: Adult; Drug Tolerance; Humans; Hyperalgesia; Male; Methadone; Narcotics; Pain; Receptors, N-Methyl-D

2006
Morphine, oxycodone, methadone and its enantiomers in different models of nociception in the rat.
    Anesthesia and analgesia, 2006, Volume: 102, Issue:6

    Topics: Acute Disease; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Male; Methadone; Morph

2006
Pharmacokinetics and pharmacodynamics of methadone enantiomers in hospice patients with cancer pain.
    Therapeutic drug monitoring, 2006, Volume: 28, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chromatography, High Pressure Liquid; Female; Ha

2006
Anesthesia and pain management for pediatric patients with dystrophic epidermolysis bullosa.
    Journal of clinical anesthesia, 2006, Volume: 18, Issue:4

    Topics: Adolescent; Anesthesia, General; Child; Child, Preschool; Conscious Sedation; Epidermolysis Bullosa

2006
Methadone-induced respiratory depression after discontinuing carbamazepine administration.
    Journal of pain and symptom management, 2006, Volume: 32, Issue:2

    Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Carbamazepine; Female; Humans; Methadone; Middle Aged;

2006
[Opioid switching and methadone in pain relief].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2006, Sep-07, Volume: 126, Issue:17

    Topics: Analgesics, Opioid; Drug Administration Schedule; Drug Tolerance; Humans; Methadone; Pain

2006
Letter to the editor regarding Sullivan et al.
    Journal of general internal medicine, 2006, Volume: 21, Issue:10

    Topics: Analgesics, Opioid; Humans; Internship and Residency; Methadone; Pain

2006
Trends and geographic variation of opiate medication use in state Medicaid fee-for-service programs, 1996 to 2002.
    Medical care, 2006, Volume: 44, Issue:11

    Topics: Analgesics, Opioid; Data Interpretation, Statistical; Drug Prescriptions; Drug Utilization; Fee-for-

2006
Effects of subcutaneous methadone, morphine, buprenorphine or saline on thermal and pressure thresholds in cats.
    Journal of veterinary pharmacology and therapeutics, 2006, Volume: 29, Issue:6

    Topics: Analgesics, Opioid; Animals; Buprenorphine; Cats; Female; Hot Temperature; Injections, Subcutaneous;

2006
Equianalgesic dosing of opioids.
    Journal of pain & palliative care pharmacotherapy, 2006, Volume: 20, Issue:4

    Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Fentanyl; Humans; Hydromorphone; Methadone; Pa

2006
Herbal product use in a patient with polypharmacy.
    The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 2006, Volume: 21, Issue:11

    Topics: Aged; Analgesics, Opioid; Dizziness; Herb-Drug Interactions; Humans; Hypotension, Orthostatic; Male;

2006
Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics.
    Anesthesiology, 2007, Volume: 106, Issue:2

    Topics: Adenosine; Analgesics, Opioid; Animals; Clonidine; Dose-Response Relationship, Drug; Fentanyl; Heroi

2007
Regarding naltrexone for probationers and parolees.
    Journal of substance abuse treatment, 2007, Volume: 32, Issue:2

    Topics: Buprenorphine; Heroin Dependence; Humans; Injections; Long-Term Care; Methadone; Naltrexone; Narcoti

2007
Medicating "Margaret".
    The Journal of clinical ethics, 2006,Winter, Volume: 17, Issue:4

    Topics: Advance Directives; Alzheimer Disease; Analgesics, Opioid; Antipsychotic Agents; Electroconvulsive T

2006
Prescription opioid abuse among enrollees into methadone maintenance treatment.
    Drug and alcohol dependence, 2007, Sep-06, Volume: 90, Issue:1

    Topics: Adult; Analgesics, Opioid; Comorbidity; Cross-Sectional Studies; Drug Prescriptions; Female; Health

2007
[Methadone in the treatment of chronic non-malignant pain].
    Ugeskrift for laeger, 2007, Apr-23, Volume: 169, Issue:17

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone

2007
Nurse case management program of chronic pain patients treated with methadone.
    Pain management nursing : official journal of the American Society of Pain Management Nurses, 2007, Volume: 8, Issue:3

    Topics: Aged; Ambulatory Care; Analgesics, Opioid; Case Management; Chronic Disease; Drug Monitoring; Feasib

2007
Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)- and racemic-methadone.
    International journal of clinical pharmacology and therapeutics, 2007, Volume: 45, Issue:7

    Topics: Adult; Alleles; Analgesics, Opioid; Cytochrome P-450 CYP2D6; Female; Genotype; Humans; Male; Methado

2007
Prescription opioid use, misuse, and diversion among street drug users in New York City.
    Drug and alcohol dependence, 2008, Jan-01, Volume: 92, Issue:1-3

    Topics: Administration, Intranasal; Adult; Aged; Analgesics, Opioid; Buprenorphine; Cocaine-Related Disorder

2008
Patient versus therapist alliance: whose perception matters?
    Journal of substance abuse treatment, 2008, Volume: 35, Issue:2

    Topics: Adult; Analgesics, Opioid; Female; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders; P

2008
Prescribing methadone for pain management in end-of-life care.
    The Journal of the American Osteopathic Association, 2005, Volume: 105, Issue:3 Suppl 1

    Topics: Drug Interactions; Humans; Methadone; Morphine; Pain; Palliative Care; Terminal Care

2005
The safety of methadone hydrochloride.
    Expert opinion on drug safety, 2008, Volume: 7, Issue:1

    Topics: Animals; Humans; Methadone; Opioid-Related Disorders; Pain; Respiratory Insufficiency

2008
High dose levo-methadone treatment for cancer pain in a patient with a history of drug addiction.
    Journal of pain and symptom management, 2008, Volume: 35, Issue:3

    Topics: Adult; Analgesics, Opioid; Carcinoma, Squamous Cell; Female; Humans; Methadone; Opioid-Related Disor

2008
Managing an acute pain crisis in a patient with advanced cancer: "this is as much of a crisis as a code".
    JAMA, 2008, Mar-26, Volume: 299, Issue:12

    Topics: Acute Disease; Adenocarcinoma, Mucinous; Adjuvants, Anesthesia; Adult; Analgesics, Opioid; Anestheti

2008
MMTP patients with chronic pain switching to pain management clinics. A problem or an acceptable practice?
    Pain medicine (Malden, Mass.), 2008, Volume: 9, Issue:3

    Topics: Adult; Analgesics, Opioid; Chronic Disease; Female; Heroin Dependence; Humans; Male; Methadone; Midd

2008
Actual and potential drug interactions associated with methadone.
    Pain medicine (Malden, Mass.), 2008, Volume: 9, Issue:3

    Topics: Analgesics, Opioid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Drug Interactions; Humans; Meth

2008
Re: subcutaneous methadone-an issue revisited.
    Journal of pain and symptom management, 2008, Volume: 35, Issue:6

    Topics: Analgesics, Opioid; Humans; Infusions, Parenteral; Injections, Subcutaneous; Methadone; Pain

2008
Increased assessment and monitoring needed for patients receiving methadone.
    The American journal of medicine, 2008, Volume: 121, Issue:5

    Topics: Analgesics, Opioid; Humans; Methadone; Opioid-Related Disorders; Pain

2008
Chronic pain in patients with substance abuse disorder: general guidelines and an approach to treatment.
    Postgraduate medicine, 2008, Volume: 120, Issue:1

    Topics: Chronic Disease; Diagnosis, Differential; Humans; Methadone; Pain; Substance-Related Disorders

2008
Substitution-detoxification and its role in the management of chronic benign pain.
    The Journal of clinical psychiatry, 1982, Volume: 43, Issue:8 Pt 2

    Topics: Acute Disease; Analgesics, Opioid; Chronic Disease; Drug Administration Schedule; Humans; Hypnotics

1982
(-)-alpha-Acetylmethadol for treatment of chronic pain patients who abuse opioids.
    Drug and alcohol dependence, 1983, Volume: 12, Issue:3

    Topics: Adult; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; Methadyl Acetate; Middl

1983
Should regional anesthesia and pharmacological agents such as beta blockers and opiates be utilized in modulating pain response?
    The Journal of trauma, 1984, Volume: 24, Issue:9 Suppl

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alfentanil; Analgesia; Analgesics; Anesth

1984
[Peroral analgetic treatment with a methadone mixture in terminal cancer patients].
    Ugeskrift for laeger, 1981, Jun-15, Volume: 143, Issue:25

    Topics: Administration, Oral; Aged; Female; Humans; Male; Methadone; Middle Aged; Neoplasms; Pain; Palliativ

1981
[Long-lasting pain relief with rectal methadone therapy].
    Lakartidningen, 1983, Jan-19, Volume: 80, Issue:3

    Topics: Aged; Female; Humans; Male; Methadone; Neoplasms; Pain; Palliative Care; Rectum; Suppositories

1983
A comparison of antinociception induced by foot shock and morphine.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 227, Issue:1

    Topics: Animals; Cyclazocine; Electroshock; Foot; Male; Methadone; Morphine; Naloxone; Nociceptors; Pain; Pe

1983
A modified submaximal effort tourniquet test for evaluation of analgesics in healthy volunteers.
    Pain, 1984, Volume: 19, Issue:2

    Topics: Adult; Analgesics; Arm; Bloodletting; Double-Blind Method; Female; Humans; Male; Methadone; Middle A

1984
Pharmacist intervention in methadone administration to cancer patients with chronic pain.
    American journal of hospital pharmacy, 1983, Volume: 40, Issue:9

    Topics: Adolescent; Adult; Aged; Chronic Disease; Humans; Methadone; Middle Aged; Neoplasms; Pain; Pharmacis

1983
A study of hospitalized surgical patients on methadone maintenance.
    NIDA research monograph, 1981, Volume: 34

    Topics: Adult; Analgesics; Female; Humans; Male; Methadone; Pain; Patient Admission; Surgical Procedures, Op

1981
Cimetidine potentiation of narcotic action.
    Drug intelligence & clinical pharmacy, 1983, Volume: 17, Issue:1

    Topics: Adenocarcinoma; Aged; Cimetidine; Drug Synergism; Guanidines; Humans; Lung Neoplasms; Male; Methadon

1983
[Morphine and methadone in severe cancer pain--new pharmacokinetic bases for optimal therapy].
    Pharmaceutica acta Helvetiae, 1983, Volume: 58, Issue:7

    Topics: Chronic Disease; Humans; Kinetics; Methadone; Morphine; Neoplasms; Pain

1983
How to use methadone. A handbook for patients and families.
    Oncology nursing forum, 1981,Winter, Volume: 8, Issue:1

    Topics: Humans; Methadone; Neoplasms; Pain; Patient Education as Topic; Self Administration

1981
The antinociceptive effects of epidural opiates in the cat: studies of the pharmacology and the effects of lipophilicity in spinal analgesia.
    Pain, 1982, Volume: 12, Issue:4

    Topics: Animals; Cats; Dose-Response Relationship, Drug; Epidural Space; Female; Fentanyl; Lipids; Male; Mep

1982
Pain control in advanced and recurrent head and neck cancer.
    Otolaryngologic clinics of North America, 1980, Volume: 13, Issue:3

    Topics: Dextroamphetamine; Drug Therapy, Combination; Electrocoagulation; Head and Neck Neoplasms; Humans; M

1980
Dantrolene treatment of opioid-induced myoclonus.
    Anesthesia and analgesia, 1995, Volume: 81, Issue:6

    Topics: Aged; Analgesics, Opioid; Dantrolene; Humans; Male; Methadone; Middle Aged; Morphine; Muscle Relaxan

1995
A four-drug pain regimen for head and neck cancers.
    The Laryngoscope, 1994, Volume: 104, Issue:6 Pt 1

    Topics: Acetaminophen; Adult; Aged; Antidepressive Agents, Tricyclic; Drug Administration Schedule; Drug The

1994
Respiratory depression in a patient receiving oral methadone for cancer pain.
    Journal of pain and symptom management, 1995, Volume: 10, Issue:5

    Topics: Administration, Oral; Female; Humans; Methadone; Middle Aged; Neoplasms; Pain; Respiration Disorders

1995
Disappearance of morphine-induced hyperalgesia after discontinuing or substituting morphine with other opioid agonists.
    Pain, 1994, Volume: 59, Issue:2

    Topics: Adult; Aged; Analgesics, Opioid; Child; Delayed-Action Preparations; Female; Humans; Hyperalgesia; M

1994
Methadone in pain uncontrolled by morphine.
    Lancet (London, England), 1993, Nov-13, Volume: 342, Issue:8881

    Topics: Adult; Female; Humans; Methadone; Morphine; Pain

1993
Methadone therapy.
    Lancet (London, England), 1993, May-15, Volume: 341, Issue:8855

    Topics: HIV Infections; Humans; Methadone; Opioid-Related Disorders; Pain

1993
CSF neuropeptides in cancer pain: effects of spinal opioid therapy.
    Acta anaesthesiologica Scandinavica, 1993, Volume: 37, Issue:5

    Topics: Aged; Bupivacaine; Female; Humans; Injections, Epidural; Injections, Spinal; Male; Methadone; Middle

1993
Rapid determination of methadone in plasma, cerebrospinal fluid, and urine by gas chromatography and its application to routine drug monitoring.
    Pharmaceutical research, 1993, Volume: 10, Issue:3

    Topics: Chromatography, Gas; Chronic Disease; Drug Monitoring; Heroin Dependence; Humans; Methadone; Pain; Q

1993
Rectal methadone in cancer patients with pain. A preliminary clinical and pharmacokinetic study.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1995, Volume: 6, Issue:8

    Topics: Administration, Rectal; Adult; Analgesics, Opioid; Colorectal Neoplasms; Female; Head and Neck Neopl

1995
Oral methadone for managing chronic nonmalignant pain.
    Journal of pain and symptom management, 1996, Volume: 11, Issue:5

    Topics: Administration, Oral; Adult; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; M

1996
Opioid rotation in patients with cancer pain. A retrospective comparison of dose ratios between methadone, hydromorphone, and morphine.
    Cancer, 1996, Aug-15, Volume: 78, Issue:4

    Topics: Administration, Oral; Aged; Aged, 80 and over; Analgesics, Opioid; Cohort Studies; Dose-Response Rel

1996
Clinical experience with oral methadone administration in the treatment of pain in 196 advanced cancer patients.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:10

    Topics: Administration, Oral; Aged; Analgesics, Opioid; Female; Humans; Male; Methadone; Middle Aged; Neopla

1996
Individualized use of methadone and opioid rotation in the comprehensive management of cancer pain associated with poor prognostic indicators.
    Pain, 1996, Volume: 67, Issue:1

    Topics: Carcinoma, Renal Cell; Drug Administration Schedule; Humans; Hydromorphone; Kidney Neoplasms; Male;

1996
International opioid consumption.
    Acta anaesthesiologica Scandinavica, 1997, Volume: 41, Issue:1 Pt 2

    Topics: Analgesics, Opioid; Denmark; Drug Utilization; Humans; Meperidine; Methadone; Morphine; Pain

1997
Pharmacologic treatment of cancer pain.
    The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13

    Topics: Analgesics, Opioid; Humans; Methadone; Morphine; Neoplasms; Pain; Therapeutic Equivalency

1997
Intravenous methadone for cancer pain unrelieved by morphine and hydromorphone: clinical observations.
    Pain, 1997, Volume: 70, Issue:1

    Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Humans; Hydromorphone; Injections, Intr

1997
[Pain, anesthesia and drug addiction].
    Revue de stomatologie et de chirurgie maxillo-faciale, 1997, Volume: 98, Issue:2

    Topics: Anesthesia; Comprehensive Health Care; Heroin; Heroin Dependence; Humans; Methadone; Morphine; Narco

1997
Intravenous high-dose methadone administered by patient controlled analgesia and continuous infusion for the treatment of cancer pain refractory to high-dose morphine.
    Pain, 1997, Volume: 73, Issue:2

    Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Dose-Response Relationship, Drug; Humans; Infusio

1997
Dose ratio between morphine and methadone in patients with cancer pain: a retrospective study.
    Cancer, 1998, Mar-15, Volume: 82, Issue:6

    Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Admini

1998
Equianalgesic dose/ratio between methadone and other opioid agonists in cancer pain: comparison of two clinical experiences.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1998, Volume: 9, Issue:1

    Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug;

1998
Substitution of another opioid for morphine. Methadone can be used to manage neuropathic pain related to cancer.
    BMJ (Clinical research ed.), 1998, Jul-04, Volume: 317, Issue:7150

    Topics: Analgesics, Opioid; Anesthetics, Dissociative; Humans; Ketamine; Methadone; N-Methylaspartate; Neopl

1998
Drugs for pain.
    The Medical letter on drugs and therapeutics, 1998, Aug-14, Volume: 40, Issue:1033

    Topics: Acetaminophen; Administration, Oral; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics

1998
Methadone: opioid, N-methyl-D-aspartate antagonist or both?
    Palliative medicine, 1998, Volume: 12, Issue:4

    Topics: Analgesics, Opioid; Humans; Methadone; N-Methylaspartate; Narcotics; Pain; Receptors, N-Methyl-D-Asp

1998
Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio?
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:10

    Topics: Administration, Oral; Aged; Analgesia; Analgesics, Opioid; Cross-Sectional Studies; Dose-Response Re

1998
Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio?
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:10

    Topics: Administration, Oral; Aged; Analgesia; Analgesics, Opioid; Cross-Sectional Studies; Dose-Response Re

1998
Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio?
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:10

    Topics: Administration, Oral; Aged; Analgesia; Analgesics, Opioid; Cross-Sectional Studies; Dose-Response Re

1998
Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio?
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:10

    Topics: Administration, Oral; Aged; Analgesia; Analgesics, Opioid; Cross-Sectional Studies; Dose-Response Re

1998
Oral methadone for the treatment of severe pain in hospitalized children: a report of five cases.
    The Clinical journal of pain, 1998, Volume: 14, Issue:4

    Topics: Administration, Oral; Analgesia, Patient-Controlled; Analgesics, Opioid; Burns; Child; Child, Presch

1998
Opioid substitution to reduce adverse effects in cancer pain management.
    The Medical journal of Australia, 1999, Jan-18, Volume: 170, Issue:2

    Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Hospice Care; Humans; Male; Medical A

1999
Enantioselective high-performance liquid chromatographic method for the determination of methadone and its main metabolite in urine using an AGP and a C8 column coupled serially.
    Journal of chromatography. B, Biomedical sciences and applications, 1999, Mar-05, Volume: 724, Issue:1

    Topics: Chromatography, High Pressure Liquid; Humans; Methadone; Pain; Reproducibility of Results; Sensitivi

1999
The relationship between the visual analog pain intensity and pain relief scale changes during analgesic drug studies in chronic pain patients.
    Anesthesiology, 1999, Volume: 91, Issue:1

    Topics: Adult; Aged; Analgesics, Opioid; Chronic Disease; Female; Humans; Hydromorphone; Male; Methadone; Mi

1999
Rapid switching from morphine to methadone in cancer patients with poor response to morphine.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:10

    Topics: Aged; Analgesics, Opioid; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Humans;

1999
Rapid switching from morphine to methadone in cancer patients with poor response to morphine.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:10

    Topics: Aged; Analgesics, Opioid; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Humans;

1999
Rapid switching from morphine to methadone in cancer patients with poor response to morphine.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:10

    Topics: Aged; Analgesics, Opioid; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Humans;

1999
Rapid switching from morphine to methadone in cancer patients with poor response to morphine.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:10

    Topics: Aged; Analgesics, Opioid; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Humans;

1999
Methadone treatment.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1999, Nov-16, Volume: 161, Issue:10

    Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pain; P

1999
Characteristics of methadone maintenance patients with chronic pain.
    Journal of pain and symptom management, 2000, Volume: 19, Issue:1

    Topics: Adult; Aged; Analgesics, Opioid; Chronic Disease; Female; Humans; Interviews as Topic; Male; Methado

2000
Use of methadone.
    The Western journal of medicine, 2000, Volume: 172, Issue:1

    Topics: Analgesics, Opioid; Drug Interactions; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonat

2000
Pain management in patients with advanced cancer.
    Annals of internal medicine, 2000, Apr-04, Volume: 132, Issue:7

    Topics: Analgesics, Opioid; Humans; Methadone; Neoplasms; Pain

2000
Respiratory depression during methadone rotation in a patient with advanced cancer.
    Journal of palliative care, 2000,Summer, Volume: 16, Issue:2

    Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Humans; Lung Neoplasms; Male; Methadone; Neoplasms; Pai

2000
Managing constipation that's opioid-induced.
    RN, 2000, Volume: 63, Issue:6

    Topics: Administration, Oral; Adult; Analgesics, Opioid; Breast Neoplasms; Chemistry, Pharmaceutical; Consti

2000
The merits of methadone.
    The American journal of nursing, 2000, Volume: 100, Issue:7

    Topics: Adult; Analgesics, Opioid; Child; Child, Preschool; Chronic Disease; Humans; Methadone; Morphine; Ne

2000
The N-methyl-D-aspartate antagonistic and opioid components of d-methadone antinociception in the rat spinal cord.
    Neuroscience letters, 2000, Dec-22, Volume: 296, Issue:2-3

    Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesia; Analgesics,

2000
Morphine and alternative opioids in cancer pain: the EAPC recommendations.
    British journal of cancer, 2001, Mar-02, Volume: 84, Issue:5

    Topics: Administration, Oral; Analgesics, Opioid; Chemistry, Pharmaceutical; Drug Administration Schedule; F

2001
Methadone in treatment of tenesmus not responding to morphine escalation.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2001, Volume: 9, Issue:2

    Topics: Aged; Analgesics, Opioid; Anus Diseases; Defecation; Humans; Male; Methadone; Morphine; Pain; Rectal

2001
Methadone and cipro interaction.
    AIDS patient care and STDs, 2001, Volume: 15, Issue:3

    Topics: Analgesics, Opioid; Anti-Infective Agents; Ciprofloxacin; Confusion; Drug Synergism; Female; Humans;

2001
Opioids in chronic non-malignant pain. Don't forget methadone for chronic pain.
    BMJ (Clinical research ed.), 2001, Sep-08, Volume: 323, Issue:7312

    Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Pain

2001
Opioid therapy for chronic painful conditions.
    Medicine and health, Rhode Island, 2001, Volume: 84, Issue:10

    Topics: Analgesics, Opioid; Chronic Disease; Clinical Trials as Topic; Fentanyl; Humans; Karnofsky Performan

2001
Methadone is safe for treating hospitalized patients with severe pain.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2001, Volume: 48, Issue:11

    Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Child; Child

2001
Methadone: the question or the answer for US opioid therapy and pharmaco-economics?
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2001, Volume: 9, Issue:8

    Topics: Analgesics, Opioid; Humans; Methadone; Models, Theoretical; Neoplasms; Opioid-Related Disorders; Pai

2001
Neurologic complications including paralysis after a medication error involving implanted intrathecal catheters.
    The American journal of medicine, 2002, Volume: 112, Issue:1

    Topics: Adult; Aged; Analgesics, Opioid; Catheters, Indwelling; Cluster Analysis; Cohort Studies; Disease Ou

2002
Methadone for refractory cancer pain.
    Journal of pain and symptom management, 2002, Volume: 23, Issue:3

    Topics: Analgesics, Opioid; Carcinoma; Humans; Male; Methadone; Middle Aged; Pain; Rectal Neoplasms

2002
Slow metabolism and long half life of methadone in a patient with lung cancer and cirrhosis.
    Annales de medecine interne, 2001, Volume: 152 Suppl 7

    Topics: Adenocarcinoma; Adult; Analgesics, Opioid; Fibrosis; Half-Life; Humans; Lung Neoplasms; Male; Metabo

2001
Opioid rotation to methadone: proceed with caution.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, May-01, Volume: 20, Issue:9

    Topics: Analgesics, Opioid; Brachial Plexus Neuropathies; Humans; Methadone; Pain; Pancoast Syndrome

2002
Differential antinociception by morphine and methadone in two sub-strains of Sprague-Dawley rats and its potentiation by dextromethorphan.
    Brain research, 2002, Jun-28, Volume: 942, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Catalepsy; Central Nervous System; Dextromethorphan; Dose-Response Rela

2002
Effect of narcotic analgesics on the striatal homovanillic acid content in mice; relation to antinociceptive effect.
    Medical biology, 1976, Volume: 54, Issue:1

    Topics: Analgesics, Opioid; Animals; Body Temperature; Corpus Striatum; Cyclazocine; Haloperidol; Homovanill

1976
Analgesic drugs in the management of pain.
    Archives of surgery (Chicago, Ill. : 1960), 1977, Volume: 112, Issue:7

    Topics: Analgesics; Anti-Anxiety Agents; Aspirin; Carbamazepine; Codeine; Dextropropoxyphene; Humans; Hypnot

1977
Studies on tolerance development to single doses of morphine in mice.
    The Journal of pharmacology and experimental therapeutics, 1976, Volume: 198, Issue:2

    Topics: 5,6-Dihydroxytryptamine; Animals; Brain; Cyclic AMP; Cycloheximide; Drug Tolerance; Female; Humans;

1976
Important clinical pharmacologic considerations in the use of methadone in cancer patients.
    Cancer treatment reports, 1979, Volume: 63, Issue:3

    Topics: Adult; Aged; Drug Administration Schedule; Female; Humans; Male; Methadone; Middle Aged; Neoplasms;

1979
Pain perception in drug-free and in methadone-maintained human ex-addicts.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1979, Volume: 162, Issue:3

    Topics: Adult; Blood Pressure; Cold Temperature; Female; Humans; Informed Consent; Male; Methadone; Pain; Su

1979
Objective tests of analgesic drugs in ponies.
    American journal of veterinary research, 1979, Volume: 40, Issue:8

    Topics: Analgesics; Animals; Disease Models, Animal; Female; Fentanyl; Horse Diseases; Horses; Male; Meperid

1979
Iatrogenic addiction and its treatment.
    The International journal of the addictions, 1978, Volume: 13, Issue:3

    Topics: Adult; Aged; Behavior Therapy; Denial, Psychological; Female; Humans; Iatrogenic Disease; Life Style

1978
Shattering myths about hospice care.
    American pharmacy, 1978, Volume: 18, Issue:12

    Topics: Hospices; Humans; Methadone; Morphine; Pain; Terminal Care

1978
Methadone for pain.
    JAMA, 1978, Dec-08, Volume: 240, Issue:24

    Topics: Administration, Oral; Biological Availability; Humans; Methadone; Pain

1978
Morphine: ability to block neuronal activity evoked by a nociceptive stimulus.
    Life sciences, 1976, Sep-15, Volume: 19, Issue:6

    Topics: Action Potentials; Animals; Brain Stem; Chlorpromazine; Levorphanol; Male; Methadone; Morphine; Nalo

1976
Drug use and distribution in a pain rehabilitation center.
    American journal of hospital pharmacy, 1975, Volume: 32, Issue:3

    Topics: Adult; Amitriptyline; Barbiturates; Chronic Disease; Diet; Female; Formularies, Hospital as Topic; H

1975
Synthesis of alpha-1-noracetylmethadol. A facile N-demethylation of alpha-1-acetylmethadol.
    Journal of medicinal chemistry, 1975, Volume: 18, Issue:6

    Topics: Animals; Dealkylation; Methadone; Methadyl Acetate; Mice; Pain; Reaction Time

1975
Letter: Drug use in a pain rehabilitation center.
    American journal of hospital pharmacy, 1975, Volume: 32, Issue:11

    Topics: Amitriptyline; Chronic Disease; Drug Combinations; Humans; Methadone; Pain; Phenytoin; Snake Venoms

1975
Custom-made suppositories of methadone for severe cancer pain.
    Journal of pain and symptom management, 1992, Volume: 7, Issue:6

    Topics: Administration, Rectal; Aged; Bone Neoplasms; Humans; Male; Methadone; Pain; Prostatic Neoplasms; Su

1992
High-dose methadone and the need for drug measurements in plasma.
    Clinical chemistry, 1991, Volume: 37, Issue:9

    Topics: Adult; Chromatography, High Pressure Liquid; Humans; Male; Methadone; Pain; Substance Abuse Treatmen

1991
Treatment of severe cancer pain by continuous infusion of subcutaneous opioids.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1991, Volume: 121

    Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Methadone; Middle A

1991
Exceptionally high narcotic analgesic requirements in a terminally ill cancer patient.
    Clinical pharmacy, 1986, Volume: 5, Issue:10

    Topics: Adult; Analgesics, Opioid; Combined Modality Therapy; Drug Tolerance; Female; Humans; Hydromorphone;

1986
Epidural methadone for analgesic management of patients with conservatively treated proximal femoral fractures.
    Journal of the American Geriatrics Society, 1989, Volume: 37, Issue:10

    Topics: Aged; Aged, 80 and over; Emergencies; Female; Femoral Neck Fractures; Humans; Injections, Epidural;

1989
Medication management in patients with chronic non-malignant pain. A review of the use of a drug withdrawal protocol.
    Pain, 1986, Volume: 26, Issue:2

    Topics: Analgesics, Opioid; Chronic Disease; Drug Combinations; Humans; Hypnotics and Sedatives; Methadone;

1986
Naltrexone.
    Journal of substance abuse treatment, 1985, Volume: 2, Issue:2

    Topics: Humans; Methadone; Naltrexone; Opioid-Related Disorders; Pain; Pituitary Gland; Receptors, Opioid; S

1985
[3-step pharmacologic treatment of pain in cancer. Preliminary experience in Chile].
    Revista medica de Chile, 1988, Volume: 116, Issue:5

    Topics: Acetaminophen; Adult; Analgesics; Chile; Codeine; Drug Administration Schedule; Female; Follow-Up St

1988
The use of methadone in opioid-tolerant patients.
    Journal of pain and symptom management, 1988,Winter, Volume: 3, Issue:1

    Topics: Adenocarcinoma; Drug Tolerance; Fallopian Tube Neoplasms; Female; Humans; Methadone; Middle Aged; Pa

1988
Methadone: pluses and minuses.
    Indiana medicine : the journal of the Indiana State Medical Association, 1987, Volume: 80, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; M

1987
The availability of narcotics and attitudes towards their use.
    Journal of pain and symptom management, 1986,Summer, Volume: 1, Issue:3

    Topics: Adrenal Gland Neoplasms; Child, Preschool; Female; Humans; Methadone; Morphine; Neuroblastoma; Pain

1986
Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain.
    Clinical pharmacology and therapeutics, 1987, Volume: 41, Issue:4

    Topics: Adult; Aged; Blood Pressure; Blood Proteins; Chronic Disease; Female; Half-Life; Humans; Kinetics; M

1987
Dilemmas in managing prostate carcinoma (Part II): Metastatic disease.
    Geriatrics, 1985, Volume: 40, Issue:9

    Topics: Aged; Aminoglutethimide; Aspirin; Bone Neoplasms; Castration; Diethylstilbestrol; Disseminated Intra

1985
The graded and quantal nature of opioid analgesia in the rat tailflick assay.
    Brain research, 1985, Apr-08, Volume: 331, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Kinetics; Male; Methadone; Morphine; Pain; Rats; Reaction

1985
[Analgesia in myocardial infarct].
    Zeitschrift fur Kardiologie, 1974, Volume: 63, Issue:12

    Topics: Analgesics; Diazepam; Heart; Hemodynamics; Heroin; Humans; Hydromorphone; Meperidine; Methadone; Mor

1974
Methadone in the relief of pain--a clinical note.
    Delaware medical journal, 1967, Volume: 39, Issue:10

    Topics: Humans; Methadone; Pain; Palliative Care

1967
[Pain in the maxillo-facial region. Diagnosis and therapy].
    Nederlands tijdschrift voor tandheelkunde, 1972, Volume: 79, Issue:2

    Topics: Adult; Apicoectomy; Dental Amalgam; Dry Socket; Facial Neuralgia; Humans; Methadone; Middle Aged; Mo

1972
The new methadone regulations.
    American journal of hospital pharmacy, 1973, Volume: 30, Issue:2

    Topics: Community Pharmacy Services; Heroin; Heroin Dependence; Humans; Legislation, Drug; Methadone; Pain;

1973
Analgesics and other drugs for relief of pain.
    Postgraduate medicine, 1973, Volume: 53, Issue:6

    Topics: Analgesics; Aspirin; Azepines; Carbamazepine; Codeine; Dextropropoxyphene; Humans; Indomethacin; Met

1973
Surgical management of pain in cancer of the head and neck.
    The Surgical clinics of North America, 1973, Volume: 53, Issue:1

    Topics: Alcohols; Autonomic Nerve Block; Carbamazepine; Chlorpromazine; Cranial Nerves; Gastrostomy; Head; H

1973
Methadone maintenance.
    JAMA, 1973, Jan-29, Volume: 223, Issue:5

    Topics: Humans; Methadone; Pain; Substance-Related Disorders

1973
Anti-nociceptive activity of some thiophthalanes with morphine-like properties.
    Acta pharmacologica et toxicologica, 1973, Volume: 32, Issue:3

    Topics: Analgesia; Analgesics; Animals; Bridged-Ring Compounds; Depression, Chemical; Dextropropoxyphene; Di

1973
Drug injection injuries of the hands and forearms in addicts.
    Plastic and reconstructive surgery, 1974, Volume: 53, Issue:4

    Topics: Adolescent; Adult; Cocaine; Edema; Female; Forearm Injuries; Gangrene; Hand Injuries; Heparin; Heroi

1974
Methadone maintenance therapy for heroin addiction. Some surgical considerations.
    American journal of surgery, 1972, Volume: 123, Issue:3

    Topics: Adult; Cardiac Surgical Procedures; Curettage; Dextropropoxyphene; Dilatation; Female; Fracture Fixa

1972
A gas-liquid chromatographic method for the quantitative determination of methadone in human plasma and urine.
    Journal of chromatography, 1972, Feb-23, Volume: 65, Issue:2

    Topics: Chromatography, Gas; Humans; Methadone; Methods; Neoplasms; Pain; Time Factors

1972
A look at narcotic and nonnarcotic analgesics.
    Postgraduate medicine, 1971, Volume: 49, Issue:6

    Topics: Analgesics; Dextropropoxyphene; Drug Antagonism; Drug Combinations; Drug Prescriptions; Drug Toleran

1971
Narcotics and medical practice. Medical use of morphine and morphine-like drugs and management of persons dependent on them.
    JAMA, 1971, Oct-25, Volume: 218, Issue:4

    Topics: American Medical Association; Female; Health Education; Heroin; Humans; Legislation, Drug; Methadone

1971
[Principles and risks of drug treatment of pain].
    Bibliotheca psychiatrica et neurologica, 1969, Volume: 139

    Topics: Aminopyrine; Analgesics; Antidepressive Agents; Antipyrine; Aspirin; Codeine; Dibenzazepines; Humans

1969
Antagonism of the analgesic effect of morphine and other drugs by p-chlorophenylalanine, a serotonin depletor.
    Psychopharmacologia, 1968, Volume: 12, Issue:4

    Topics: Analgesia; Animals; Brain; Codeine; Dextropropoxyphene; Electroshock; Male; Methadone; Morphine; Pai

1968
[Research on the placebo effect in postoperative pain].
    Rassegna internazionale di clinica e terapia, 1969, Aug-31, Volume: 49, Issue:16

    Topics: Female; Humans; Male; Methadone; Pain; Placebos; Postoperative Complications; Pyrazoles; Sulfonic Ac

1969