methadone has been researched along with Pain, Intractable in 90 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Pain, Intractable: Persistent pain that is refractory to some or all forms of treatment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although methadone has the potential to improve the management of cancer pain, it has some serious problems, such as respiratory depression and QT interval prolongation." | 8.02 | Assistance of a Palliative Care Certified Nurse in the Alleviation of Refractory Cancer Pain by Switching Opioids to Oral Methadone in a Japanese Outpatient Setting. ( Matsuda, Y; Okayama, S, 2021) |
| "To summarize the unique characteristics of methadone and the putative mechanisms of rapid-onset opioid formulations for breakthrough pain; to outline the principles underlying opioid rotation; and to describe elements of risk assessment in opioid therapy." | 4.85 | Clinical approaches to special issues related to opioid therapy. ( Fine, PG, 2009) |
| "In our article ?Methadone switching for refractory cancer pain' (BMC palliative care, 2022) we explore the efficacy, safety and economics of methadone in treatment of patients with refractory cancer pain in China." | 4.31 | Reply to "A better interpretation of data regarding the opioid switching to methadone". ( Ding, H; Fang, L; Gong, L; He, C; Song, Y; Sun, J; Xin, W; Zhong, L; Zhou, Q, 2023) |
| "Although methadone has the potential to improve the management of cancer pain, it has some serious problems, such as respiratory depression and QT interval prolongation." | 4.02 | Assistance of a Palliative Care Certified Nurse in the Alleviation of Refractory Cancer Pain by Switching Opioids to Oral Methadone in a Japanese Outpatient Setting. ( Matsuda, Y; Okayama, S, 2021) |
| "Methadone was significantly less expensive, but required more changes, up and down, of the doses, suggesting that dose titration of this drug requires major clinical expertise." | 2.73 | Sustained-release oral morphine versus transdermal fentanyl and oral methadone in cancer pain management. ( Aielli, F; Casuccio, A; Ferrera, P; Ficorella, C; Fulfaro, F; Gebbia, V; Mangione, S; Mercadante, S; Porzio, G; Riina, S; Verna, L; Villari, P, 2008) |
| " Analgesic effects (lowered maximum pain intensity and increased pain relief, on the day of dosing only) were also seen when the lower daily dose of 10 mg methadone (given as 5 mg bd) was used, but these failed to reach statistical significance (P = 0." | 2.71 | Low-dose methadone has an analgesic effect in neuropathic pain: a double-blind randomized controlled crossover trial. ( Bridson, J; Makin, MK; Miles, JB; Morley, JS; Nash, TP; White, S, 2003) |
| "Methadone was initiated 8-24 hours after fentanyl withdrawal, depending on the patient's previous opioid doses (from < 100 microg per hour to > 300 microg per hour)." | 2.71 | Opioid switching from transdermal fentanyl to oral methadone in patients with cancer pain. ( Benítez-Rosario, MA; Feria, M; Martín-Ortega, JJ; Martínez-Castillo, LP; Salinas-Martín, A, 2004) |
| "Methadone is a drug of indisputable value in the treatment of cancer pain, and an unbalanced focus on the risks of inappropriate use rather than the benefits should not compromise the use of a relevant alternative to morphine in the management of cancer pain." | 2.69 | Morphine versus methadone in the pain treatment of advanced-cancer patients followed up at home. ( Agnello, A; Barresi, L; Calderone, L; Casuccio, A; Mercadante, S; Serretta, R, 1998) |
| " Dosing intervals, pain intensity assessments and toxicity were evaluated." | 2.66 | Does intravenous methadone provide longer lasting analgesia than intravenous morphine? A randomized, double-blind study. ( Enterline, J; Green, L; Grochow, L; Grossman, S; Sheidler, V, 1989) |
| "Refractory cancer pain that does not respond to standard opioid and/or co-analgesic therapy occurs in 10-20 % of patients." | 2.52 | Pharmacological options for the management of refractory cancer pain-what is the evidence? ( Afsharimani, B; Good, P; Hardy, J; Kindl, K, 2015) |
| "Methadone is a potent synthetic opioid analgesic best known in Australia as maintenance therapy for narcotic addicts." | 2.41 | The rediscovery of methadone for cancer pain management. ( Ayonrinde, OT; Bridge, DT, 2000) |
| " Issues to be explored include a potential role in treating patients who have poorly responsive pain syndromes, such as neuropathic pain, or who develop a rapid tolerance to other opioids; the possibility of extending dosing intervals to every 12 or 24 hours; and its possible use as a first-line opioid." | 2.40 | Role of methadone in the management of pain in cancer patients. ( Bruera, E; Neumann, CM, 1999) |
| "Methadone is a commonly used opioid in hospice and palliative care for patients with refractory pain." | 1.39 | Dose ratios between high dose oral morphine or equivalents and oral methadone. ( Chatham, MS; Dodds Ashley, ES; Juba, KM; Svengsouk, JS, 2013) |
| "Methadone has been reported to be as effective as morphine for cancer pain management." | 1.39 | Methadone rotation for cancer patients with refractory pain in a palliative care unit: an observational study. ( Bruera, E; Ciais, JF; Filbet, M; Ledoux, M; Rhondali, W; Tremellat, F, 2013) |
| " The primary reasons respondents did not utilize methadone included a lack of knowledge of methadone's pharmacodynamics (39%), effectiveness (39%), and/or dosing equivalence (34%)." | 1.39 | Attitudes and practices of pediatric oncologists regarding methadone use in the treatment of cancer-related pain: results of a North American Survey. ( Davies, D; Friebert, S; Kim, M; Roth, M; Wang, D; Zelcer, S, 2013) |
| "This paper reports two cases of myoclonus with high-dose parenteral methadone in patients with cancer under hospice care." | 1.35 | Myoclonus associated with high-dose parenteral methadone. ( Ito, S; Liao, S, 2008) |
| "Methadone dose was significantly correlated to stable MEDD after switching opioids for both methadone IV and oral (Spearman = 0." | 1.35 | Switching from methadone to a different opioid: what is the equianalgesic dose ratio? ( Bruera, E; Hanohano, J; Kaur, G; Munsell, M; Palla, S; Pei, BL; Walker, PW; Zhang, K, 2008) |
| "We analyzed 54 cancer patients undergoing opioid rotation to clarify those factors that influenced the morphine/methadone dose ratio (MMEDR) at Day 10 after the switch." | 1.35 | Morphine-methadone opioid rotation in cancer patients: analysis of dose ratio predicting factors. ( Aguirre-Jaime, A; Benítez-Rosario, MA; Feria, M; Pérez-Méndez, L; Salinas-Martín, A, 2009) |
| "Levorphanol has been reported to provide analgesia at doses that suggest it does not act like other pure agonist opioids." | 1.34 | Can levorphanol be used like methadone for intractable refractory pain? ( McNulty, JP, 2007) |
| "Fentanyl patches were removed and the first of three daily doses of methadone was started concurrently." | 1.34 | Opioid plasma concentrations during a switch from transdermal fentanyl to methadone. ( Casuccio, A; Ferrera, P; Gambaro, V; Mercadante, S; Villari, P, 2007) |
| "Methadone is a synthetic opioid agonist and N-methyl-D-aspartate (NMDA) receptor antagonist that is being increasingly used in pain management, particularly for pain that is resistant to conventional opioids." | 1.33 | Rotation to methadone after opioid dose escalation: How should individualization of dosing occur? ( Booth, CM; Cottrell, W; Seccareccia, D; Zimmermann, C, 2005) |
| "Methadone was offered as a treatment option to consecutive cancer and noncancer patients with neuropathic pain." | 1.32 | Methadone in the treatment of neuropathic pain. ( Almahrezi, A; Gagnon, B; Schreier, G, 2003) |
| "Methadone is a unique opioid with several special properties besides being a mu agonist, which makes for difficulty in the calculation of equianalgesic doses." | 1.31 | Methadone as a rescue for failed high-dose opiate therapy for catastrophic pain. ( Davis, MP, 2000) |
| "1 mg/hour of methadone may be safe and effective." | 1.31 | Intravenous methadone in the management of chronic cancer pain: safe and effective starting doses when substituting methadone for fentanyl. ( Fischberg, DJ; Khojainova, N; Kornick, C; Manfredi, P; Payne, R; Primavera, LH; Santiago-Palma, J, 2001) |
| "Methadone has many pharmacokinetic characteristics that fit it for use in this clinical situation." | 1.30 | Treatment of pain in chronic bowel subobstruction with self-administration of methadone. ( Mercadante, S; Sapio, M; Serretta, R, 1997) |
| "Dipipanone elixir was formulated 10 mg/5 ml, in single strength chloroform water." | 1.29 | Experience with dipipanone elixir in the management of cancer related pain--case study. ( Ahmedzai, S; Faull, C; McKechnie, E; Riley, J, 1994) |
| "Methadone is a potent opioid analgesic that demonstrates incomplete cross-tolerance with other mu-opioid receptor agonist analgesics." | 1.29 | Clinical efficacy of methadone in patients refractory to other mu-opioid receptor agonist analgesics for management of terminal cancer pain. Case presentations and discussion of incomplete cross-tolerance among opioid agonist analgesics. ( Crews, JC; Denson, DD; Sweeney, NJ, 1993) |
| "Seventy cancer patients suffering from visceral or somatic pain received continuous epidural methadone (EM) analgesia." | 1.28 | Continuous epidural methadone treatment for cancer pain. ( Kaufman, B; Magora, F; Shapira, SS; Shenkman, Z; Shir, Y, 1991) |
| "Morphine was used in 36 CIs, methadone in four, hydromorphone in four, oxymorphone in one, and levorphanol in one." | 1.27 | I.v. infusion of opioids for cancer pain: clinical review and guidelines for use. ( Foley, KM; Inturrisi, CE; Moulin, DE; Portenoy, RK; Rogers, A, 1986) |
| " Rapid and continuous pain relief without serious side-effects was achieved by "ad libitum" dosage in the first 3-5 days." | 1.26 | Clinical evaluation of oral methadone in treatment of cancer pain. ( Anggård, E; Ginman, C; Hansen, J; Hartvig, P; Jakobsson, PA; Nilsson, MI; Rane, A; Säwe, J, 1982) |
| " Long-term use of analgesic drugs in chronic pain usually produces negative behavioral complications that are more difficult to manage than the pain it was desired to eliminate." | 1.26 | Analgesic drugs in the management of pain. ( Halpern, LM, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (27.78) | 18.7374 |
| 1990's | 20 (22.22) | 18.2507 |
| 2000's | 30 (33.33) | 29.6817 |
| 2010's | 12 (13.33) | 24.3611 |
| 2020's | 3 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Murakami, S | 1 |
| Asada, T | 1 |
| Kubota, T | 1 |
| Kawakami, H | 1 |
| Kokubun, H | 1 |
| Uezono, Y | 1 |
| Ding, H | 1 |
| Song, Y | 1 |
| Xin, W | 1 |
| Sun, J | 1 |
| Zhong, L | 1 |
| Zhou, Q | 1 |
| He, C | 1 |
| Gong, L | 1 |
| Fang, L | 1 |
| Okayama, S | 2 |
| Matsuda, Y | 2 |
| Mulder, DJ | 1 |
| Sherlock, ME | 1 |
| Lysecki, DL | 1 |
| Yoshikawa, Y | 1 |
| Kilonzo, I | 1 |
| Twomey, F | 1 |
| Chatham, MS | 1 |
| Dodds Ashley, ES | 1 |
| Svengsouk, JS | 1 |
| Juba, KM | 1 |
| Rhondali, W | 1 |
| Tremellat, F | 1 |
| Ledoux, M | 1 |
| Ciais, JF | 1 |
| Bruera, E | 6 |
| Filbet, M | 1 |
| Rasmussen, VF | 1 |
| Lundberg, V | 1 |
| Jespersen, TW | 1 |
| Hasle, H | 1 |
| Afsharimani, B | 1 |
| Kindl, K | 1 |
| Good, P | 1 |
| Hardy, J | 1 |
| Leyva Carmona, M | 1 |
| Gómez Bueno, S | 1 |
| Ruiz Tudela, L | 1 |
| Aguirre Rodríguez, J | 1 |
| Sanchez, F | 1 |
| Prommer, EE | 1 |
| Ito, S | 1 |
| Liao, S | 1 |
| Walker, PW | 1 |
| Palla, S | 1 |
| Pei, BL | 1 |
| Kaur, G | 1 |
| Zhang, K | 1 |
| Hanohano, J | 1 |
| Munsell, M | 1 |
| Benítez-Rosario, MA | 2 |
| Salinas-Martín, A | 2 |
| Aguirre-Jaime, A | 1 |
| Pérez-Méndez, L | 1 |
| Feria, M | 2 |
| Fine, PG | 1 |
| Lebovits, A | 1 |
| Hainline, B | 1 |
| Stone, LS | 1 |
| Seminowicz, DA | 1 |
| Brunz, JT | 1 |
| Rosenquist, RW | 1 |
| Cowan, P | 1 |
| Portenoy, RK | 3 |
| González-Barboteo, J | 1 |
| Trelis-Navarro, J | 1 |
| Tuca-Rodríguez, A | 1 |
| Gómez-Batiste, X | 1 |
| Poels, M | 1 |
| Joppich, R | 1 |
| Gerbershagen, K | 1 |
| Wappler, F | 1 |
| Roth, M | 1 |
| Davies, D | 2 |
| Friebert, S | 1 |
| Wang, D | 1 |
| Kim, M | 1 |
| Zelcer, S | 1 |
| Breitfeld, C | 1 |
| Eikermann, M | 1 |
| Kienbaum, P | 1 |
| Peters, J | 1 |
| Mercadante, S | 6 |
| Bianchi, M | 3 |
| Villari, P | 3 |
| Ferrera, P | 3 |
| Casuccio, A | 5 |
| Fulfaro, F | 2 |
| Gebbia, V | 2 |
| Morley, JS | 2 |
| Bridson, J | 1 |
| Nash, TP | 1 |
| Miles, JB | 1 |
| White, S | 1 |
| Makin, MK | 2 |
| Friedman, R | 1 |
| Kamel, I | 1 |
| Perez, C | 1 |
| Hamada, A | 1 |
| Gagnon, B | 1 |
| Almahrezi, A | 1 |
| Schreier, G | 1 |
| Tsui, BC | 1 |
| Desai, S | 1 |
| Malherbe, S | 1 |
| Martínez-Castillo, LP | 1 |
| Martín-Ortega, JJ | 1 |
| Pérez Martínez, J | 1 |
| Arguis Giménez, MJ | 1 |
| Fernández Candil, JL | 1 |
| Martínez Fernández, G | 1 |
| Sinche Yupanqui, M | 1 |
| Moreno Cuartas, LA | 1 |
| Galard Hernández, JJ | 1 |
| Gomar Sancho, C | 1 |
| Jung, BF | 1 |
| Reidenberg, MM | 1 |
| Zimmermann, C | 1 |
| Seccareccia, D | 1 |
| Booth, CM | 1 |
| Cottrell, W | 1 |
| Moulin, DE | 2 |
| Palma, D | 1 |
| Watling, C | 1 |
| Schulz, V | 1 |
| Fayez, K | 1 |
| Juan-Diego, H | 1 |
| Oscar A, de LC | 1 |
| Fredheim, OM | 1 |
| Borchgrevink, PC | 1 |
| Klepstad, P | 1 |
| Kaasa, S | 1 |
| Dale, O | 1 |
| McNulty, JP | 1 |
| Hagen, NA | 1 |
| Fisher, K | 1 |
| Stiles, C | 1 |
| Gambaro, V | 1 |
| Okon, T | 1 |
| Sekine, R | 1 |
| Obbens, EA | 1 |
| Coyle, N | 1 |
| Inturrisi, CE | 3 |
| Porzio, G | 1 |
| Aielli, F | 1 |
| Verna, L | 1 |
| Ficorella, C | 1 |
| Riina, S | 1 |
| Mangione, S | 1 |
| Reich, SD | 1 |
| Gourlay, GK | 1 |
| Cousins, MJ | 1 |
| Warfield, CA | 1 |
| Stein, JM | 1 |
| Kepes, ER | 1 |
| Raj, S | 1 |
| Thomas, P | 1 |
| Vemulapalli, K | 1 |
| Ferrer-Brechner, T | 1 |
| Ganz, P | 1 |
| Pierce, J | 1 |
| Ya Deau, RE | 1 |
| Maxwell, MB | 1 |
| Martinson, IM | 1 |
| Nixon, S | 1 |
| Geis, D | 1 |
| YaDeau, R | 1 |
| Nesbit, M | 1 |
| Kersey, J | 1 |
| Hansen, J | 1 |
| Ginman, C | 1 |
| Hartvig, P | 1 |
| Jakobsson, PA | 1 |
| Nilsson, MI | 1 |
| Rane, A | 1 |
| Säwe, J | 1 |
| Anggård, E | 1 |
| Breivik, H | 1 |
| Rennemo, F | 1 |
| Paalzow, L | 1 |
| Nilsson, L | 1 |
| Stenberg, P | 1 |
| Berken, GH | 1 |
| Stone, MM | 1 |
| Stone, SK | 1 |
| Portnow, JM | 1 |
| Corbett, RJ | 1 |
| Faull, C | 1 |
| McKechnie, E | 1 |
| Riley, J | 1 |
| Ahmedzai, S | 1 |
| Leng, G | 1 |
| Finnegan, MJ | 1 |
| Crews, JC | 1 |
| Sweeney, NJ | 1 |
| Denson, DD | 1 |
| Fainsinger, R | 2 |
| Schoeller, T | 1 |
| O'Rourke, MA | 1 |
| Shalabi, A | 1 |
| Webb, S | 1 |
| Watanabe, S | 1 |
| Belzile, M | 1 |
| Kuehn, N | 1 |
| Hanson, J | 1 |
| Sapio, M | 1 |
| Serretta, R | 2 |
| Zylicz, Z | 1 |
| Agnello, A | 2 |
| Calderone, L | 1 |
| Barresi, L | 2 |
| Donnadieu, S | 1 |
| Djian, MC | 1 |
| Clavenna, A | 1 |
| Groff, L | 1 |
| Zecca, E | 1 |
| Ripamonti, C | 2 |
| Neumann, CM | 1 |
| Rashiq, S | 1 |
| Davis, MP | 1 |
| Shir, Y | 2 |
| Shvelzon, V | 1 |
| Rosen, G | 1 |
| Ayonrinde, OT | 1 |
| Bridge, DT | 1 |
| Clark, KJ | 1 |
| Turner, K | 1 |
| Santiago-Palma, J | 1 |
| Khojainova, N | 1 |
| Kornick, C | 1 |
| Fischberg, DJ | 1 |
| Primavera, LH | 1 |
| Payne, R | 1 |
| Manfredi, P | 1 |
| Sabatowski, R | 1 |
| Kasper, SM | 1 |
| Radbruch, L | 1 |
| Halpern, LM | 1 |
| Blaine, JD | 1 |
| Valentine, AS | 1 |
| Steckel, S | 1 |
| Weintraub, M | 1 |
| Catlin, DH | 1 |
| Hui, KK | 1 |
| Loh, HH | 1 |
| Li, CH | 2 |
| Shapira, SS | 1 |
| Shenkman, Z | 1 |
| Kaufman, B | 1 |
| Magora, F | 1 |
| Moore, M | 1 |
| Thibault, R | 1 |
| Spoldi, E | 1 |
| Ventafridda, V | 2 |
| Hampf, GB | 1 |
| Kalso, EA | 1 |
| Kennedy, JA | 1 |
| Crowley, TJ | 1 |
| Max, MB | 1 |
| Kaiko, RF | 1 |
| Grabinski, PY | 1 |
| Foley, KM | 3 |
| Rogers, A | 1 |
| Grochow, L | 1 |
| Sheidler, V | 1 |
| Grossman, S | 1 |
| Green, L | 1 |
| Enterline, J | 1 |
| Sbanotto, A | 1 |
| De Conno, F | 1 |
| Rogers, AG | 1 |
| Richlin, DM | 1 |
| Jamron, LM | 1 |
| Novick, NL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Influence of Aging on Perioperative Methadone Dosing[NCT04526236] | Phase 4 | 60 participants (Actual) | Interventional | 2019-09-03 | Completed | ||
| Methadone for 'Adenocarcinopathic' Pain Treatment: Methadone vs. Morphine Vanguard RCT[NCT05325164] | Phase 3 | 0 participants (Actual) | Interventional | 2022-09-30 | Withdrawn (stopped due to Trial not started; change in Sponsor and Principal Investigator, trial to be registered again by new Sponsor/Investigator if it is started.) | ||
| Oral Ketamine for Control of Chronic Pain in Children[NCT01369680] | Phase 1 | 12 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| Switching From Morphine to Oral Methadone Plus Acetaminophen in the Treatment of Cancer Pain: A Randomized, Double-Blind Study[NCT00525967] | Phase 2/Phase 3 | 50 participants (Anticipated) | Interventional | 2006-02-28 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Baseline neurocognitive testing will be done before study drug is given. Subjects will be reassessed for any changes in neurocognitive scores at end of dosing (week 2) and at three weeks off study drug (week 14). Significant changes were measured at week 14 compared to baseline. Week 2 was measured to inform future studies.~The neurocognitive scores are standardized scores with a mean of 100; low scores correlate with low neurocognitive function, while high scores correlate with high function. A significant change is defined as greater than or equal to 10% decrease in scores." (NCT01369680)
Timeframe: At 14 weeks
| Intervention | participants (Number) |
|---|---|
| Ketamine 0.25 mg/kg/Dose | 0 |
| Ketamine 0.5 mg/kg/Dose | 0 |
| Ketamine 1 mg/kg/Dose | 0 |
| Ketamine 1.5 mg/kg/Dose | 0 |
Pharmacokinetic testing will be done during chronic ketamine administration on subjects consenting to additional testing one week into study drug administration. This is to further describe the activity of ketamine in the blood of children when administered chronically and to enable comparison of any clinical effect or toxicity with steady state levels of ketamine in children. (NCT01369680)
Timeframe: At week 1
| Intervention | ng/mL (Mean) |
|---|---|
| Ketamine 0.25 mg/kg/Dose | 37.5 |
| Ketamine 0.5 mg/kg/Dose | 135 |
| Ketamine 1 mg/kg/Dose | 250 |
According to CTCae any dose causing grade 2 or worse toxicity will be an untolerated dose. Tolerability is defined as ability to take the medication for 2 weeks without having a grade 2 or worse toxicity. (NCT01369680)
Timeframe: Up to 2 weeks
| Intervention | participants (Number) |
|---|---|
| Ketamine 0.25 mg/kg/Dose | 3 |
| Ketamine 0.5 mg/kg/Dose | 3 |
| Ketamine 1 mg/kg/Dose | 3 |
| Ketamine 1.5 mg/kg/Dose | 1 |
"Subjects will be assessed for clinically significant change in pain scores during and after study drug administration. Significant change in pain scores were determined at week 2, though week 14 scores were collected as well.~Participants with a 2 point (or greater) decrease in pain scores compared to baseline were considered to have responded. The NRS scale was used, the scale ranges from 0-10, with 10 being the most pain." (NCT01369680)
Timeframe: Week 2
| Intervention | participants (Number) |
|---|---|
| Ketamine 0.25 mg/kg/Dose | 3 |
| Ketamine 0.5 mg/kg/Dose | 0 |
| Ketamine 1 mg/kg/Dose | 2 |
| Ketamine 1.5 mg/kg/Dose | 0 |
8 reviews available for methadone and Pain, Intractable
| Article | Year |
|---|---|
Pharmacological options for the management of refractory cancer pain-what is the evidence?
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; B | 2015 |
Clinical approaches to special issues related to opioid therapy.
Topics: Analgesics, Opioid; Humans; Methadone; Neoplasms; Nurse's Role; Nursing Assessment; Nursing Methodol | 2009 |
[Opioid rotation: a therapeutic choice in the management of refractory cancer pain].
Topics: Adult; Age Factors; Aged; Child; Dose-Response Relationship, Drug; Drug Administration Schedule; Hum | 2010 |
Interpretation of opioid levels: comparison of levels during chronic pain therapy to levels from forensic autopsies.
Topics: Analgesics, Opioid; Autopsy; Fentanyl; Humans; Methadone; Morphine; Oxycodone; Pain, Intractable | 2005 |
Ketamine: an introduction for the pain and palliative medicine physician.
Topics: Adult; Amines; Analgesics; Analgesics, Opioid; Central Nervous System; Cryoglobulinemia; Cyclohexane | 2007 |
Methadone in the management of cancer pain: a review.
Topics: Humans; Methadone; Neoplasms; Pain, Intractable | 1993 |
Role of methadone in the management of pain in cancer patients.
Topics: Analgesics, Opioid; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Humans; Male | 1999 |
The rediscovery of methadone for cancer pain management.
Topics: Analgesics, Opioid; Humans; Methadone; Neoplasms; Pain, Intractable; Prospective Studies | 2000 |
13 trials available for methadone and Pain, Intractable
| Article | Year |
|---|---|
Low-dose methadone has an analgesic effect in neuropathic pain: a double-blind randomized controlled crossover trial.
Topics: Adult; Aged; Analgesics, Opioid; Confidence Intervals; Cross-Over Studies; Double-Blind Method; Drug | 2003 |
Opioid switching from transdermal fentanyl to oral methadone in patients with cancer pain.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Aged; Analgesics, Opioid; Drug Administratio | 2004 |
Long term methadone for chronic pain: a pilot study of pharmacokinetic aspects.
Topics: Adult; Aged; Analgesics, Opioid; Chronic Disease; Dose-Response Relationship, Drug; Drug Administrat | 2007 |
Sustained-release oral morphine versus transdermal fentanyl and oral methadone in cancer pain management.
Topics: Administration, Cutaneous; Administration, Oral; Adolescent; Adult; Aged; Analgesia; Analgesics, Opi | 2008 |
Combination therapy with ibuprofen and methadone for chronic cancer pain.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Emotions; Fem | 1984 |
Comments on Ripamonti et al., Pain, 70 (1997) 109-115.
Topics: Analgesics, Opioid; Humans; Methadone; Morphine; Pain, Intractable | 1997 |
Morphine versus methadone in the pain treatment of advanced-cancer patients followed up at home.
Topics: Adult; Aged; Analgesics, Opioid; Female; Home Care Services; Humans; Male; Methadone; Middle Aged; M | 1998 |
Diclofenac does not modify methadone bioavailability in cancer patients.
Topics: Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Diclofen | 1999 |
Methadone response in advanced cancer patients with pain followed at home.
Topics: Analgesics, Opioid; Female; Home Care Services; Humans; Male; Methadone; Middle Aged; Neoplasms; Pai | 1999 |
Early clinical studies of levo-alpha acetylmethadol (LAAM): an opiate for use in the medical treatment of chronic heroin dependence.
Topics: Arousal; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Drug Admin | 1978 |
Pain relief for cancer patients.
Topics: Chloroform; Clinical Trials as Topic; Cocaine; Dextrothyroxine; Drug Combinations; Drug Evaluation; | 1978 |
Does intravenous methadone provide longer lasting analgesia than intravenous morphine? A randomized, double-blind study.
Topics: Adult; Aged; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Inje | 1989 |
A randomized study on oral administration of morphine and methadone in the treatment of cancer pain.
Topics: Administration, Oral; Clinical Trials as Topic; Female; Humans; Male; Methadone; Morphine; Neoplasms | 1986 |
69 other studies available for methadone and Pain, Intractable
| Article | Year |
|---|---|
A Successful Case of Switching Treatment from Ketamine to Methadone for Complex Neuropathic Pain.
Topics: Activities of Daily Living; Analgesics, Opioid; Humans; Ketamine; Methadone; Neuralgia; Pain, Intrac | 2022 |
Reply to "A better interpretation of data regarding the opioid switching to methadone".
Topics: Analgesics, Opioid; Cancer Pain; Dose-Response Relationship, Drug; Humans; Methadone; Neoplasms; Pai | 2023 |
Assistance of a Palliative Care Certified Nurse in the Alleviation of Refractory Cancer Pain by Switching Opioids to Oral Methadone in a Japanese Outpatient Setting.
Topics: Analgesics, Opioid; Cancer Pain; Humans; Japan; Methadone; Neoplasms; Outpatients; Pain, Intractable | 2021 |
NMDA-receptor Antagonism in Pediatric Pancreatitis: Use of Ketamine and Methadone in a Teenager With Refractory Pain.
Topics: Adolescent; Analgesics; Humans; Ketamine; Male; Methadone; Off-Label Use; Pain Management; Pain Meas | 2018 |
A Comparative Study of Opioid Switching to Methadone for Cancer Pain Control in Successful and Unsuccessful Cases.
Topics: Aged; Analgesics, Opioid; Cancer Pain; Drug Substitution; Female; Humans; Japan; Male; Methadone; Mi | 2019 |
Rotating to oral methadone in advanced cancer patients: a case series.
Topics: Adult; Aged; Analgesics, Opioid; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Drug Ad | 2013 |
Dose ratios between high dose oral morphine or equivalents and oral methadone.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Hospice C | 2013 |
Methadone rotation for cancer patients with refractory pain in a palliative care unit: an observational study.
Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Humans; Male; Methadone; Middle | 2013 |
Extreme doses of intravenous methadone for severe pain in two children with cancer.
Topics: Adolescent; Analgesics, Opioid; Child; Female; Humans; Injections, Intravenous; Male; Methadone; Neo | 2015 |
[Oral methadone for the management of difficult to control pain in Fabry disease].
Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Fabry Disease; Humans; Male; Methadone; Neural | 2018 |
Opioid-induced pain.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; | 2008 |
Myoclonus associated with high-dose parenteral methadone.
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Hospice Care; Humans; Male; Methadone; | 2008 |
Switching from methadone to a different opioid: what is the equianalgesic dose ratio?
Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Humans; Male; Methadone; Middle | 2008 |
Morphine-methadone opioid rotation in cancer patients: analysis of dose ratio predicting factors.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cohort Studies; Dose-Response Relationship, Drug | 2009 |
Struck from behind: maintaining quality of life with chronic low back pain.
Topics: Accidents, Traffic; Activities of Daily Living; Adult; Analgesics, Opioid; Bupropion; Depression; Do | 2009 |
Recent advances in the treatment of cancer pain.
Topics: Analgesics, Opioid; Humans; Methadone; Neoplasms; Pain, Intractable; Palliative Care | 2010 |
[Analgesic therapy of calciphylaxis with levomethadone : a case study].
Topics: Aged; Analgesics, Opioid; Calciphylaxis; Combined Modality Therapy; Cooperative Behavior; Dose-Respo | 2010 |
Attitudes and practices of pediatric oncologists regarding methadone use in the treatment of cancer-related pain: results of a North American Survey.
Topics: Female; Health Knowledge, Attitudes, Practice; Humans; Long QT Syndrome; Male; Medical Oncology; Met | 2013 |
Opioid "holiday" following antagonist supported detoxification during general anesthesia improves opioid agonist response in a cancer patient with opioid addiction.
Topics: Analgesia, Epidural; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bone Neoplasms; Bu | 2003 |
Opioid plasma concentration during switching from morphine to methadone: preliminary data.
Topics: Administration, Oral; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Administratio | 2003 |
Severe intraoperative hypertension and opioid-resistant postoperative pain in a methadone-treated patient.
Topics: Adult; Analgesics, Opioid; Drug Resistance; Female; Hemodynamics; Humans; Hypertension; Intraoperati | 2003 |
Methadone in the treatment of neuropathic pain.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Male; Methadone; Middle Aged; Mononeuropathies; Pain | 2003 |
Methadone in the treatment of neuropathic pain.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Male; Methadone; Middle Aged; Mononeuropathies; Pain | 2003 |
Methadone in the treatment of neuropathic pain.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Male; Methadone; Middle Aged; Mononeuropathies; Pain | 2003 |
Methadone in the treatment of neuropathic pain.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Male; Methadone; Middle Aged; Mononeuropathies; Pain | 2003 |
Intravenous ketamine infusion as an adjuvant to morphine in a 2-year-old with severe cancer pain from metastatic neuroblastoma.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Child, Preschool; Codeine; Drug | 2004 |
[Intrathecal methadone for cancer pain after vulvectomy].
Topics: Analgesics, Opioid; Carcinoma; Combined Modality Therapy; Female; Humans; Hyperalgesia; Hysterectomy | 2004 |
Rotation to methadone after opioid dose escalation: How should individualization of dosing occur?
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Humans; Hydromorphone; Methadone; Midd | 2005 |
Methadone in the management of intractable neuropathic noncancer pain.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anticonvulsants; Antidepressive Agents, Tricyclic; Fem | 2005 |
Re: Methadone in the management of intractable neuropathic noncancer pain.
Topics: Analgesics, Opioid; Electrocardiography; Humans; Long QT Syndrome; Methadone; Neuralgia; Pain, Intra | 2006 |
Can levorphanol be used like methadone for intractable refractory pain?
Topics: Analgesics, Opioid; Chronic Disease; Hospice Care; Humans; Levorphanol; Louisiana; Methadone; Pain M | 2007 |
Sublingual methadone for the management of cancer-related breakthrough pain: a pilot study.
Topics: Administration, Sublingual; Aged; Alberta; Analgesics, Opioid; Clinical Protocols; Drug Monitoring; | 2007 |
Opioid plasma concentrations during a switch from transdermal fentanyl to methadone.
Topics: Administration, Cutaneous; Adult; Aged; Analgesics, Opioid; Drug Administration Schedule; Female; Fe | 2007 |
The successful use of parenteral methadone in a patient with a prolonged QTc interval.
Topics: Analgesics, Opioid; Carcinoma, Renal Cell; Humans; Infusions, Parenteral; Kidney Neoplasms; Long QT | 2007 |
Pharmaceutics: choice of a strong analgesic for cancer patients.
Topics: Analgesics, Opioid; Humans; Methadone; Morphine; Neoplasms; Pain, Intractable | 1982 |
Strong analgesics in severe pain.
Topics: Analgesics, Opioid; Chronic Disease; Cocaine; Fentanyl; Half-Life; Heroin; Humans; Injections, Intra | 1984 |
The pain clinic: the use of systemic analgesics.
Topics: Adult; Aged; Amitriptyline; Analgesics; Anti-Inflammatory Agents; Anticonvulsants; Bone Neoplasms; D | 1982 |
Methadone and intravenous morphine requirements. Treatment of pain due to advanced cancer.
Topics: Adolescent; Adult; Aged; Female; Humans; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain, In | 1983 |
Methadone for pain relief in disseminated malignant disease.
Topics: Female; Humans; Male; Methadone; Neoplasm Metastasis; Neoplasms; Pain, Intractable; Terminal Care | 1980 |
How to use methadone for the cancer patient's pain.
Topics: Dose-Response Relationship, Drug; Humans; Methadone; Neoplasms; Pain, Intractable | 1980 |
Nursing care in childhood cancer: methadone.
Topics: Adolescent; Analgesics; Child; Child, Preschool; Humans; Infant; Liver; Methadone; Neoplasms; Pain, | 1982 |
Clinical evaluation of oral methadone in treatment of cancer pain.
Topics: Administration, Oral; Adult; Aged; Female; Half-Life; Humans; Male; Methadone; Middle Aged; Neoplasm | 1982 |
Clinical evaluation of combined treatment with methadone and psychotropic drugs in cancer patients.
Topics: Adult; Aged; Drug Therapy, Combination; Female; Haloperidol; Humans; Male; Methadone; Middle Aged; M | 1982 |
Pharmacokinetic basis for optimal methadone treatment of pain in cancer patients.
Topics: Adult; Aged; Female; Half-Life; Humans; Kinetics; Male; Methadone; Middle Aged; Models, Biological; | 1982 |
Methadone: an effective agent in managing intractable pain as a symptom of psychotic anger.
Topics: Adult; Anger; Female; Humans; Methadone; Middle Aged; Migraine Disorders; Pain, Intractable; Psychop | 1982 |
Oral methadone for relief of chronic pain from cancer.
Topics: Chronic Disease; Humans; Methadone; Morphine; Neoplasms; Pain, Intractable | 1982 |
Experience with dipipanone elixir in the management of cancer related pain--case study.
Topics: Aged; Aged, 80 and over; Analgesics; Dosage Forms; Female; Humans; Male; Methadone; Middle Aged; Neo | 1994 |
Successful use of methadone in nociceptive cancer pain unresponsive to morphine.
Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Methado | 1994 |
Clinical efficacy of methadone in patients refractory to other mu-opioid receptor agonist analgesics for management of terminal cancer pain. Case presentations and discussion of incomplete cross-tolerance among opioid agonist analgesics.
Topics: Adolescent; Adult; Analgesics; Child; Drug Tolerance; Female; Humans; Male; Methadone; Middle Aged; | 1993 |
Methadone for treatment of cancer pain.
Topics: Analgesics, Opioid; Drug and Narcotic Control; Humans; Methadone; Neoplasms; Pain, Intractable | 1996 |
Capsules and suppositories of methadone for patients on high-dose opioids for cancer pain: clinical and economic considerations.
Topics: Adult; Aged; Analgesics, Opioid; Capsules; Female; Humans; Male; Methadone; Middle Aged; Neoplasms; | 1996 |
Treatment of pain in chronic bowel subobstruction with self-administration of methadone.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Breast Neoplasms; Chronic Disease; Fatal O | 1997 |
Opioid responsive central pain of cerebrovascular origin: a case report.
Topics: Analgesics, Opioid; Cerebrovascular Disorders; Humans; Male; Methadone; Middle Aged; Morphine; Pain, | 1997 |
[Pain therapy].
Topics: Adult; Age Factors; Analgesics; Analgesics, Opioid; Child; Codeine; Humans; Methadone; Neurosurgery; | 1998 |
Methadone treatment.
Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pain; P | 1999 |
Methadone as a rescue for failed high-dose opiate therapy for catastrophic pain.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Breast Neoplasms; Carcinoma, Squamous Cell; Female; | 2000 |
[Treating hospitalized children in severe pain with oral methadone].
Topics: Administration, Oral; Analgesics, Opioid; Burns; Child; Child, Hospitalized; Child, Preschool; Femal | 1998 |
The rediscovery of methadone for cancer pain management.
Topics: Humans; Methadone; Neoplasms; Pain, Intractable | 2001 |
Intravenous methadone in the management of chronic cancer pain: safe and effective starting doses when substituting methadone for fentanyl.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Drug Administration Schedule; Female | 2001 |
Patient-controlled analgesia with intravenous L-methadone in a child with cancer pain refractory to high-dose morphine.
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Child; Humans; Infusions, Intravenous; Male; Meth | 2002 |
Analgesic drugs in the management of pain.
Topics: Analgesics; Anti-Anxiety Agents; Aspirin; Carbamazepine; Codeine; Dextropropoxyphene; Humans; Hypnot | 1977 |
Pharmacologic activity of beta-endorphin in man.
Topics: Analgesics; Dose-Response Relationship, Drug; Endorphins; Heroin Dependence; Humans; Methadone; Morp | 1977 |
Continuous epidural methadone treatment for cancer pain.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Chronic Disease; Female; Humans; Ma | 1991 |
Local toxicity with subcutaneous methadone. Experience of two centers.
Topics: Adult; Erythema; Female; Humans; Injections, Subcutaneous; Male; Methadone; Middle Aged; Neoplasms; | 1991 |
Chronic use of opioids in intractable facial pain. A case report.
Topics: Administration, Oral; Facial Pain; Female; Humans; Methadone; Middle Aged; Pain, Intractable | 1991 |
Chronic pain and substance abuse: a pilot study of opioid maintenance.
Topics: Adult; Analgesics, Opioid; Combined Modality Therapy; Female; Humans; Long-Term Care; Male; Methadon | 1990 |
Epidural and intrathecal opiates: cerebrospinal fluid and plasma profiles in patients with chronic cancer pain.
Topics: Adult; Aged; beta-Endorphin; Drug Evaluation; Endorphins; Epidural Space; Female; Half-Life; Humans; | 1985 |
I.v. infusion of opioids for cancer pain: clinical review and guidelines for use.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Drug Administration Schedule; Drug Evaluation; Hum | 1986 |
Chronic use of opioid analgesics in non-malignant pain: report of 38 cases.
Topics: Adult; Aged; Analgesics, Opioid; Female; Humans; Levorphanol; Male; Methadone; Middle Aged; Opioid-R | 1986 |
Changing the route of administration in children.
Topics: Administration, Oral; Child; Female; Humans; Injections, Intravenous; Methadone; Morphine; Pain, Int | 1986 |
Cancer pain control with a combination of methadone, amitriptyline, and non-narcotic analgesic therapy: a case series analysis.
Topics: Adolescent; Adult; Aged; Amitriptyline; Analgesics; Drug Therapy, Combination; Female; Humans; Male; | 1987 |
Managing intractable pain with methadone (nursing grand rounds).
Topics: Adenocarcinoma; Female; Humans; Methadone; Middle Aged; Morphine; Pain, Intractable; Patient Care Pl | 1985 |