Page last updated: 2024-10-30

methadone and Neuralgia

methadone has been researched along with Neuralgia in 35 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.

Research Excerpts

ExcerptRelevanceReference
"The use of methadone in the treatment of cancer pain is becoming more attractive mainly because of its known efficacy, lack of active metabolites, and low cost."9.09Differences in the ratios of morphine to methadone in patients with neuropathic pain versus non-neuropathic pain. ( Bruera, E; Gagnon, B, 1999)
"Methadone is a useful option in the treatment of cancer pain."8.12Methadone rotation for cancer pain: an observational study. ( Hum, A; Tan, C; Wong, JF; Yee, CM, 2022)
"Our primary objective was test the hypothesis that oral methadone combined with oral ketamine is more effective than oral methadone or ketamine alone in reducing neuropathic pain."6.84Management of Neuropathic Chronic Pain with Methadone Combined with Ketamine: A Randomized, Double Blind, Active-Controlled Clinical Trial. ( Caumo, W; Dalmolin, GD; Ferreira, J; Godoy, MC; Menezes, MS; Rigo, FK; Rossato, MF; Silva, MA; Trevisan, G, 2017)
"The use of methadone in the treatment of cancer pain is becoming more attractive mainly because of its known efficacy, lack of active metabolites, and low cost."5.09Differences in the ratios of morphine to methadone in patients with neuropathic pain versus non-neuropathic pain. ( Bruera, E; Gagnon, B, 1999)
"We identified both randomized controlled trials (RCTs) and non-randomized studies of methadone use in chronic pain by searching the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library 2011, issue 11, MEDLINE (1950 to November 2011), and EMBASE (1980 to November 2011), together with reference lists of retrieved papers and reviews."4.88Methadone for chronic non-cancer pain in adults. ( Haroutiunian, S; Lipman, AG; McNicol, ED, 2012)
"Methadone is a useful option in the treatment of cancer pain."4.12Methadone rotation for cancer pain: an observational study. ( Hum, A; Tan, C; Wong, JF; Yee, CM, 2022)
" A 61-year-old man presented with severe cognitive dysfunction after long-term methadone treatment for intercostal neuralgia and was diagnosed with GH insufficiency by GH releasing hormone-arginine testing."3.80Recombinant human growth hormone improves cognitive capacity in a pain patient exposed to chronic opioids. ( Gordh, T; Grönbladh, A; Nyberg, F; Ortiz-Nieto, F; Raininko, R; Rhodin, A; Skottheim, B; von Ehren, M, 2014)
"We studied the effects of the commonly used mu-opioid receptor agonists morphine, oxycodone, methadone and the enantiomers of methadone in thermal and mechanical models of acute pain and in the spinal nerve ligation model of neuropathic pain in rats."3.73Morphine, oxycodone, methadone and its enantiomers in different models of nociception in the rat. ( Kalso, E; Kontinen, VK; Kylänlahti, I; Lemberg, K; Viljakka, K; Yli-Kauhaluoma, J, 2006)
"Our primary objective was test the hypothesis that oral methadone combined with oral ketamine is more effective than oral methadone or ketamine alone in reducing neuropathic pain."2.84Management of Neuropathic Chronic Pain with Methadone Combined with Ketamine: A Randomized, Double Blind, Active-Controlled Clinical Trial. ( Caumo, W; Dalmolin, GD; Ferreira, J; Godoy, MC; Menezes, MS; Rigo, FK; Rossato, MF; Silva, MA; Trevisan, G, 2017)
"Cancer pain is still inadequately treated in up to 60% of cancer patients."2.82Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer. ( Geurts, JW; Haumann, J; Joosten, EA; Kremer, B; van den Beuken-van Everdingen, MH; van Kuijk, SM, 2016)
"Methadone has many characteristics that differentiate it from other opioids, which suggests that it may have a different efficacy and safety profile."2.55Methadone for neuropathic pain in adults. ( Ferguson, MC; McNicol, ED; Schumann, R, 2017)
"Pharmacological management of neuropathic pain should be based on a stepwise intervention strategy, as combinations of medications are the most effective approach."1.51Neuropathic Pain in Pediatric Oncology: A Clinical Decision Algorithm. ( Anghelescu, DL; Tesney, JM, 2019)
"Compared with nociceptive pain, neuropathic pain is a challenging diagnosis to make and successfully treat in children with cancer."1.46Very-Low-Dose Methadone To Treat Refractory Neuropathic Pain in Children with Cancer. ( Bruera, E; Madden, K, 2017)
"Methadone is an opioid analgesic that is effective in the treatment of neuropathic pain, is excreted by the bowels, is highly lipophilic, and can be administered through the oral, buccal, or sublingual routes."1.43Use of Methadone as an Adjuvant Medication to Low-Dose Opioids for Neuropathic Pain in the Frail Elderly: A Case Series. ( Grief, CJ; Grossman, D; Kirstein, A; Pan, J; Vu Bach, T, 2016)
"To this purpose, in rats with neuropathic pain model of chronic constriction of one sciatic nerve (CCI rats), we administered methadone before or after opioid receptor blockade with naloxone and checked its effects on the spinal Wide Dynamic Range (WDR) neuron dynamics in three experimental conditions: on the spontaneous and noxious evoked neuronal activities in control rats (sham operated and naïve); on iontophoretic NMDA induced neuronal hyperactivity in intact rats; on pain-related spontaneous and noxious evoked hyperactivities in CCI rats."1.35Cooperative N-methyl-D-aspartate (NMDA) receptor antagonism and mu-opioid receptor agonism mediate the methadone inhibition of the spinal neuron pain-related hyperactivity in a rat model of neuropathic pain. ( Biella, GE; Caramenti, G; Sotgiu, ML; Storchi, R; Valente, M, 2009)
"Neuropathic pain is associated with several sensory abnormalities, including allodynia as well as spontaneous pain."1.34Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. ( Buechler, NL; Eisenach, JC; Kim, SA; Martin, TJ; Porreca, F, 2007)
"We present a patient with intractable neuropathic pain because of radiation-induced transverse myelitis unresponsive to medical treatment."1.34Spinal cord stimulator relieves neuropathic pain in a patient with radiation-induced transverse myelitis. ( Haider, N; Hamid, B, 2007)
"Conventional pharmacotherapies against neuropathic pain were attempted to control pain for over 5 years."1.31Successful use of methadone in the treatment of chronic neuropathic pain arising from burn injuries: a case-study. ( Altier, N; Boulanger, A; Choinière, M; Dion, D, 2001)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.86)18.2507
2000's9 (25.71)29.6817
2010's18 (51.43)24.3611
2020's7 (20.00)2.80

Authors

AuthorsStudies
Takemura, M1
Niki, K1
Okamoto, Y1
Matsuda, Y2
Omae, T1
Takagi, T1
Ueda, M1
Murakami, S1
Asada, T1
Kubota, T1
Kawakami, H1
Kokubun, H1
Uezono, Y1
Lai, G1
Aroke, EN1
Zhang, SJ1
Tan, C1
Wong, JF1
Yee, CM1
Hum, A1
Linciano, P1
Rossino, G1
Listro, R1
Rossi, D1
Collina, S1
Hanna, V1
Senderovich, H1
Okayama, S1
Rigo, FK2
Trevisan, G1
Godoy, MC1
Rossato, MF2
Dalmolin, GD2
Silva, MA1
Menezes, MS1
Caumo, W1
Ferreira, J2
McNicol, ED2
Ferguson, MC1
Schumann, R1
Madden, K1
Bruera, E2
Jones, JH1
Li, A1
Smith, SK1
Roy, L1
Fras, AM1
Anghelescu, DL1
Tesney, JM1
de Godoy, MC1
de Menezes, MS1
Alvarez, MA1
Hernandes, JJ1
Moreno, LA1
Sinche, M1
Kilonzo, I1
Twomey, F1
Leppert, W1
Kowalski, G1
Rhodin, A1
von Ehren, M1
Skottheim, B1
Grönbladh, A1
Ortiz-Nieto, F1
Raininko, R1
Gordh, T1
Nyberg, F1
Takase, N1
Ikegaki, J1
Nishimura, H1
Yuasa, S1
Ito, Y1
Kizawa, Y1
Haumann, J2
Geurts, JW2
van Kuijk, SM2
Kremer, B2
Joosten, EA2
van den Beuken-van Everdingen, MH2
Vu Bach, T1
Pan, J1
Kirstein, A1
Grief, CJ1
Grossman, D1
Ruan, X1
Luo, JJ1
Kaye, AD1
Leyva Carmona, M1
Gómez Bueno, S1
Ruiz Tudela, L1
Aguirre Rodríguez, J1
Sanchez, F1
Sotgiu, ML1
Valente, M1
Storchi, R1
Caramenti, G1
Biella, GE1
Nordt, SP1
Zilberstein, J1
Gold, B1
Connolly, I1
Zaleon, C1
Montagnini, M1
Haroutiunian, S1
Lipman, AG1
Manfredi, PL1
Foley, KM1
Fayez, K1
Juan-Diego, H1
Oscar A, de LC1
Colvin, L1
Forbes, K1
Fallon, M1
Lemberg, K1
Kontinen, VK1
Viljakka, K1
Kylänlahti, I1
Yli-Kauhaluoma, J1
Kalso, E1
Martin, TJ1
Kim, SA1
Buechler, NL1
Porreca, F1
Eisenach, JC1
Hamid, B1
Haider, N1
Gagnon, B1
Altier, N1
Dion, D1
Boulanger, A1
Choinière, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Methadone for 'Adenocarcinopathic' Pain Treatment: Methadone vs. Morphine Vanguard RCT[NCT05325164]Phase 30 participants (Actual)Interventional2022-09-30Withdrawn (stopped due to Trial not started; change in Sponsor and Principal Investigator, trial to be registered again by new Sponsor/Investigator if it is started.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for methadone and Neuralgia

ArticleYear
Sigma-1 receptor antagonists: promising players in fighting neuropathic pain.
    Pharmaceutical patent analyst, 2020, Volume: 9, Issue:3

    Topics: Analgesics, Opioid; Animals; Humans; Methadone; Narcotic Antagonists; Neuralgia; Nortriptyline; Pate

2020
Methadone in Pain Management: A Systematic Review.
    The journal of pain, 2021, Volume: 22, Issue:3

    Topics: Analgesics, Opioid; Cancer Pain; Humans; Methadone; Neuralgia; Nociceptive Pain; Outcome Assessment,

2021
Methadone for neuropathic pain in adults.
    The Cochrane database of systematic reviews, 2017, 05-17, Volume: 5

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Humans; Methadone; Neuralgia; Pain Measurement; Patie

2017
Management of severe neuropathic cancer pain: an illustrative case and review.
    The American journal of hospice & palliative care, 2013, Volume: 30, Issue:1

    Topics: Aged; Analgesics, Opioid; Anticonvulsants; Drug Therapy, Combination; Head and Neck Neoplasms; Human

2013
Methadone for chronic non-cancer pain in adults.
    The Cochrane database of systematic reviews, 2012, Nov-14, Volume: 11

    Topics: Adult; Analgesics, Opioid; Chronic Pain; Humans; Methadone; Neuralgia; Neuralgia, Postherpetic; Rand

2012
Difficult pain.
    BMJ (Clinical research ed.), 2006, May-06, Volume: 332, Issue:7549

    Topics: Acupuncture; Analgesia; Analgesics, Opioid; Forecasting; Humans; Methadone; Nervous System Diseases;

2006

Trials

3 trials available for methadone and Neuralgia

ArticleYear
Management of Neuropathic Chronic Pain with Methadone Combined with Ketamine: A Randomized, Double Blind, Active-Controlled Clinical Trial.
    Pain physician, 2017, Volume: 20, Issue:3

    Topics: Adult; Aged; Chronic Pain; Double-Blind Method; Female; Humans; Ketamine; Male; Methadone; Middle Ag

2017
Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer.
    European journal of cancer (Oxford, England : 1990), 2016, Volume: 65

    Topics: Adult; Aged; Analgesics, Opioid; Cancer Pain; Female; Fentanyl; Head and Neck Neoplasms; Humans; Mal

2016
Differences in the ratios of morphine to methadone in patients with neuropathic pain versus non-neuropathic pain.
    Journal of pain and symptom management, 1999, Volume: 18, Issue:2

    Topics: Adult; Aged; Analgesics, Opioid; Drug Administration Schedule; Female; Humans; Male; Methadone; Midd

1999

Other Studies

26 other studies available for methadone and Neuralgia

ArticleYear
Tapentadol in Cancer Patients with Neuropathic Pain: A Comparison of Methadone, Oxycodone, Fentanyl, and Hydromorphone.
    Biological & pharmaceutical bulletin, 2021, Volume: 44, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cancer Pain; Dose-Response Relationship, Drug; F

2021
A Successful Case of Switching Treatment from Ketamine to Methadone for Complex Neuropathic Pain.
    Journal of palliative medicine, 2022, Volume: 25, Issue:4

    Topics: Activities of Daily Living; Analgesics, Opioid; Humans; Ketamine; Methadone; Neuralgia; Pain, Intrac

2022
Rediscovery of Methadone to Improve Outcomes in Pain Management.
    Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses, 2022, Volume: 37, Issue:4

    Topics: Analgesics, Opioid; Humans; Methadone; Neuralgia; Pain Management

2022
Methadone rotation for cancer pain: an observational study.
    BMJ supportive & palliative care, 2022, Volume: 12, Issue:e6

    Topics: Analgesics, Opioid; Cancer Pain; Humans; Methadone; Morphine; Neoplasms; Neuralgia

2022
Oral Methadone for Patients With Neuropathic Pain Due to Neoplastic Brachial Plexopathy.
    Journal of palliative care, 2022, Volume: 37, Issue:2

    Topics: Analgesics, Opioid; Brachial Plexus Neuropathies; Head and Neck Neoplasms; Humans; Methadone; Neural

2022
Very-Low-Dose Methadone To Treat Refractory Neuropathic Pain in Children with Cancer.
    Journal of palliative medicine, 2017, Volume: 20, Issue:11

    Topics: Amines; Analgesics; Analgesics, Opioid; Cancer Pain; Child; Child, Preschool; Chronic Pain; Cyclohex

2017
Conservative Management of Neuropathic Pain in a Patient With Pancoast-Tobias Syndrome: A Case Report.
    A&A practice, 2018, Jul-15, Volume: 11, Issue:2

    Topics: Analgesics, Opioid; Conservative Treatment; Female; Humans; Methadone; Middle Aged; Neuralgia; Panco

2018
Neuropathic Pain in Pediatric Oncology: A Clinical Decision Algorithm.
    Paediatric drugs, 2019, Volume: 21, Issue:2

    Topics: Adult; Algorithms; Analgesics; Child; Chronic Pain; Clinical Decision-Making; Humans; Ketamine; Medi

2019
Management of chronic neuropathic pain of different causes with the combination of oral methadone along with ketamine: A report of 18 cases.
    European journal of anaesthesiology, 2013, Volume: 30, Issue:10

    Topics: Administration, Oral; Adult; Analgesics, Opioid; Chronic Pain; Drug Combinations; Female; Humans; Ke

2013
Rotating to oral methadone in advanced cancer patients: a case series.
    Journal of palliative medicine, 2013, Volume: 16, Issue:9

    Topics: Adult; Aged; Analgesics, Opioid; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Drug Ad

2013
Methadone as an additional opioid for a cancer patient with severe neuropathic and bone pain not responsive to other opioids and adjuvant analgesics.
    Journal of palliative care, 2013,Summer, Volume: 29, Issue:2

    Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Buprenorphine; Drug Therapy, Co

2013
Recombinant human growth hormone improves cognitive capacity in a pain patient exposed to chronic opioids.
    Acta anaesthesiologica Scandinavica, 2014, Volume: 58, Issue:6

    Topics: Apoptosis; Arginine; Aspartic Acid; Cognition Disorders; Creatine; Growth Hormone; Growth Hormone-Re

2014
Methadone for Patients with Malignant Psoas Syndrome: Case Series of Three Patients.
    Journal of palliative medicine, 2015, Volume: 18, Issue:7

    Topics: Adult; Aged; Analgesics, Opioid; Female; Humans; Male; Methadone; Middle Aged; Muscle Neoplasms; Neu

2015
Use of Methadone as an Adjuvant Medication to Low-Dose Opioids for Neuropathic Pain in the Frail Elderly: A Case Series.
    Journal of palliative medicine, 2016, Volume: 19, Issue:12

    Topics: Aged; Analgesics; Analgesics, Opioid; Frail Elderly; Humans; Methadone; Neuralgia

2016
Letter response: Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer.
    European journal of cancer (Oxford, England : 1990), 2016, Volume: 68

    Topics: Analgesics, Opioid; Fentanyl; Head and Neck Neoplasms; Humans; Methadone; Neuralgia; Pain; Pain Meas

2016
Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer.
    European journal of cancer (Oxford, England : 1990), 2016, Volume: 68

    Topics: Analgesics, Opioid; Fentanyl; Head and Neck Neoplasms; Humans; Methadone; Neoplasms; Neuralgia; Pain

2016
[Oral methadone for the management of difficult to control pain in Fabry disease].
    Anales de pediatria, 2018, Volume: 88, Issue:1

    Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Fabry Disease; Humans; Male; Methadone; Neural

2018
Cooperative N-methyl-D-aspartate (NMDA) receptor antagonism and mu-opioid receptor agonism mediate the methadone inhibition of the spinal neuron pain-related hyperactivity in a rat model of neuropathic pain.
    Pharmacological research, 2009, Volume: 60, Issue:4

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Male; Methadone; Neuralgia; Neurons; Rats; Rats, Spra

2009
Methadone-induced torsade de pointes.
    The American journal of emergency medicine, 2011, Volume: 29, Issue:4

    Topics: Analgesics, Opioid; Humans; Male; Methadone; Middle Aged; Neuralgia; Torsades de Pointes

2011
Opioids versus antidepressants in postherpetic neuralgia: a randomized, placebo-controlled trial.
    Neurology, 2003, Mar-25, Volume: 60, Issue:6

    Topics: Analgesics, Opioid; Herpes Zoster; Humans; Methadone; Morphine; Neuralgia; Neurotransmitter Uptake I

2003
Opioids and chronic neuropathic pain.
    The New England journal of medicine, 2003, Mar-27, Volume: 348, Issue:13

    Topics: Analgesics, Opioid; Chronic Disease; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Levor

2003
Re: Methadone in the management of intractable neuropathic noncancer pain.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2006, Volume: 33, Issue:1

    Topics: Analgesics, Opioid; Electrocardiography; Humans; Long QT Syndrome; Methadone; Neuralgia; Pain, Intra

2006
Morphine, oxycodone, methadone and its enantiomers in different models of nociception in the rat.
    Anesthesia and analgesia, 2006, Volume: 102, Issue:6

    Topics: Acute Disease; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Male; Methadone; Morph

2006
Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics.
    Anesthesiology, 2007, Volume: 106, Issue:2

    Topics: Adenosine; Analgesics, Opioid; Animals; Clonidine; Dose-Response Relationship, Drug; Fentanyl; Heroi

2007
Spinal cord stimulator relieves neuropathic pain in a patient with radiation-induced transverse myelitis.
    Pain practice : the official journal of World Institute of Pain, 2007, Volume: 7, Issue:4

    Topics: Analgesics, Opioid; Antidepressive Agents, Second-Generation; Carcinoma, Non-Small-Cell Lung; Combin

2007
Successful use of methadone in the treatment of chronic neuropathic pain arising from burn injuries: a case-study.
    Burns : journal of the International Society for Burn Injuries, 2001, Volume: 27, Issue:7

    Topics: Analgesics, Opioid; Burns; Chronic Disease; Humans; Leg Injuries; Male; Methadone; Middle Aged; Neur

2001