methadone has been researched along with Neuralgia in 35 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The use of methadone in the treatment of cancer pain is becoming more attractive mainly because of its known efficacy, lack of active metabolites, and low cost." | 9.09 | Differences in the ratios of morphine to methadone in patients with neuropathic pain versus non-neuropathic pain. ( Bruera, E; Gagnon, B, 1999) |
| "Methadone is a useful option in the treatment of cancer pain." | 8.12 | Methadone rotation for cancer pain: an observational study. ( Hum, A; Tan, C; Wong, JF; Yee, CM, 2022) |
| "Our primary objective was test the hypothesis that oral methadone combined with oral ketamine is more effective than oral methadone or ketamine alone in reducing neuropathic pain." | 6.84 | Management of Neuropathic Chronic Pain with Methadone Combined with Ketamine: A Randomized, Double Blind, Active-Controlled Clinical Trial. ( Caumo, W; Dalmolin, GD; Ferreira, J; Godoy, MC; Menezes, MS; Rigo, FK; Rossato, MF; Silva, MA; Trevisan, G, 2017) |
| "The use of methadone in the treatment of cancer pain is becoming more attractive mainly because of its known efficacy, lack of active metabolites, and low cost." | 5.09 | Differences in the ratios of morphine to methadone in patients with neuropathic pain versus non-neuropathic pain. ( Bruera, E; Gagnon, B, 1999) |
| "We identified both randomized controlled trials (RCTs) and non-randomized studies of methadone use in chronic pain by searching the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library 2011, issue 11, MEDLINE (1950 to November 2011), and EMBASE (1980 to November 2011), together with reference lists of retrieved papers and reviews." | 4.88 | Methadone for chronic non-cancer pain in adults. ( Haroutiunian, S; Lipman, AG; McNicol, ED, 2012) |
| "Methadone is a useful option in the treatment of cancer pain." | 4.12 | Methadone rotation for cancer pain: an observational study. ( Hum, A; Tan, C; Wong, JF; Yee, CM, 2022) |
| " A 61-year-old man presented with severe cognitive dysfunction after long-term methadone treatment for intercostal neuralgia and was diagnosed with GH insufficiency by GH releasing hormone-arginine testing." | 3.80 | Recombinant human growth hormone improves cognitive capacity in a pain patient exposed to chronic opioids. ( Gordh, T; Grönbladh, A; Nyberg, F; Ortiz-Nieto, F; Raininko, R; Rhodin, A; Skottheim, B; von Ehren, M, 2014) |
| "We studied the effects of the commonly used mu-opioid receptor agonists morphine, oxycodone, methadone and the enantiomers of methadone in thermal and mechanical models of acute pain and in the spinal nerve ligation model of neuropathic pain in rats." | 3.73 | Morphine, oxycodone, methadone and its enantiomers in different models of nociception in the rat. ( Kalso, E; Kontinen, VK; Kylänlahti, I; Lemberg, K; Viljakka, K; Yli-Kauhaluoma, J, 2006) |
| "Our primary objective was test the hypothesis that oral methadone combined with oral ketamine is more effective than oral methadone or ketamine alone in reducing neuropathic pain." | 2.84 | Management of Neuropathic Chronic Pain with Methadone Combined with Ketamine: A Randomized, Double Blind, Active-Controlled Clinical Trial. ( Caumo, W; Dalmolin, GD; Ferreira, J; Godoy, MC; Menezes, MS; Rigo, FK; Rossato, MF; Silva, MA; Trevisan, G, 2017) |
| "Cancer pain is still inadequately treated in up to 60% of cancer patients." | 2.82 | Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer. ( Geurts, JW; Haumann, J; Joosten, EA; Kremer, B; van den Beuken-van Everdingen, MH; van Kuijk, SM, 2016) |
| "Methadone has many characteristics that differentiate it from other opioids, which suggests that it may have a different efficacy and safety profile." | 2.55 | Methadone for neuropathic pain in adults. ( Ferguson, MC; McNicol, ED; Schumann, R, 2017) |
| "Pharmacological management of neuropathic pain should be based on a stepwise intervention strategy, as combinations of medications are the most effective approach." | 1.51 | Neuropathic Pain in Pediatric Oncology: A Clinical Decision Algorithm. ( Anghelescu, DL; Tesney, JM, 2019) |
| "Compared with nociceptive pain, neuropathic pain is a challenging diagnosis to make and successfully treat in children with cancer." | 1.46 | Very-Low-Dose Methadone To Treat Refractory Neuropathic Pain in Children with Cancer. ( Bruera, E; Madden, K, 2017) |
| "Methadone is an opioid analgesic that is effective in the treatment of neuropathic pain, is excreted by the bowels, is highly lipophilic, and can be administered through the oral, buccal, or sublingual routes." | 1.43 | Use of Methadone as an Adjuvant Medication to Low-Dose Opioids for Neuropathic Pain in the Frail Elderly: A Case Series. ( Grief, CJ; Grossman, D; Kirstein, A; Pan, J; Vu Bach, T, 2016) |
| "To this purpose, in rats with neuropathic pain model of chronic constriction of one sciatic nerve (CCI rats), we administered methadone before or after opioid receptor blockade with naloxone and checked its effects on the spinal Wide Dynamic Range (WDR) neuron dynamics in three experimental conditions: on the spontaneous and noxious evoked neuronal activities in control rats (sham operated and naïve); on iontophoretic NMDA induced neuronal hyperactivity in intact rats; on pain-related spontaneous and noxious evoked hyperactivities in CCI rats." | 1.35 | Cooperative N-methyl-D-aspartate (NMDA) receptor antagonism and mu-opioid receptor agonism mediate the methadone inhibition of the spinal neuron pain-related hyperactivity in a rat model of neuropathic pain. ( Biella, GE; Caramenti, G; Sotgiu, ML; Storchi, R; Valente, M, 2009) |
| "Neuropathic pain is associated with several sensory abnormalities, including allodynia as well as spontaneous pain." | 1.34 | Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. ( Buechler, NL; Eisenach, JC; Kim, SA; Martin, TJ; Porreca, F, 2007) |
| "We present a patient with intractable neuropathic pain because of radiation-induced transverse myelitis unresponsive to medical treatment." | 1.34 | Spinal cord stimulator relieves neuropathic pain in a patient with radiation-induced transverse myelitis. ( Haider, N; Hamid, B, 2007) |
| "Conventional pharmacotherapies against neuropathic pain were attempted to control pain for over 5 years." | 1.31 | Successful use of methadone in the treatment of chronic neuropathic pain arising from burn injuries: a case-study. ( Altier, N; Boulanger, A; Choinière, M; Dion, D, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.86) | 18.2507 |
| 2000's | 9 (25.71) | 29.6817 |
| 2010's | 18 (51.43) | 24.3611 |
| 2020's | 7 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Takemura, M | 1 |
| Niki, K | 1 |
| Okamoto, Y | 1 |
| Matsuda, Y | 2 |
| Omae, T | 1 |
| Takagi, T | 1 |
| Ueda, M | 1 |
| Murakami, S | 1 |
| Asada, T | 1 |
| Kubota, T | 1 |
| Kawakami, H | 1 |
| Kokubun, H | 1 |
| Uezono, Y | 1 |
| Lai, G | 1 |
| Aroke, EN | 1 |
| Zhang, SJ | 1 |
| Tan, C | 1 |
| Wong, JF | 1 |
| Yee, CM | 1 |
| Hum, A | 1 |
| Linciano, P | 1 |
| Rossino, G | 1 |
| Listro, R | 1 |
| Rossi, D | 1 |
| Collina, S | 1 |
| Hanna, V | 1 |
| Senderovich, H | 1 |
| Okayama, S | 1 |
| Rigo, FK | 2 |
| Trevisan, G | 1 |
| Godoy, MC | 1 |
| Rossato, MF | 2 |
| Dalmolin, GD | 2 |
| Silva, MA | 1 |
| Menezes, MS | 1 |
| Caumo, W | 1 |
| Ferreira, J | 2 |
| McNicol, ED | 2 |
| Ferguson, MC | 1 |
| Schumann, R | 1 |
| Madden, K | 1 |
| Bruera, E | 2 |
| Jones, JH | 1 |
| Li, A | 1 |
| Smith, SK | 1 |
| Roy, L | 1 |
| Fras, AM | 1 |
| Anghelescu, DL | 1 |
| Tesney, JM | 1 |
| de Godoy, MC | 1 |
| de Menezes, MS | 1 |
| Alvarez, MA | 1 |
| Hernandes, JJ | 1 |
| Moreno, LA | 1 |
| Sinche, M | 1 |
| Kilonzo, I | 1 |
| Twomey, F | 1 |
| Leppert, W | 1 |
| Kowalski, G | 1 |
| Rhodin, A | 1 |
| von Ehren, M | 1 |
| Skottheim, B | 1 |
| Grönbladh, A | 1 |
| Ortiz-Nieto, F | 1 |
| Raininko, R | 1 |
| Gordh, T | 1 |
| Nyberg, F | 1 |
| Takase, N | 1 |
| Ikegaki, J | 1 |
| Nishimura, H | 1 |
| Yuasa, S | 1 |
| Ito, Y | 1 |
| Kizawa, Y | 1 |
| Haumann, J | 2 |
| Geurts, JW | 2 |
| van Kuijk, SM | 2 |
| Kremer, B | 2 |
| Joosten, EA | 2 |
| van den Beuken-van Everdingen, MH | 2 |
| Vu Bach, T | 1 |
| Pan, J | 1 |
| Kirstein, A | 1 |
| Grief, CJ | 1 |
| Grossman, D | 1 |
| Ruan, X | 1 |
| Luo, JJ | 1 |
| Kaye, AD | 1 |
| Leyva Carmona, M | 1 |
| Gómez Bueno, S | 1 |
| Ruiz Tudela, L | 1 |
| Aguirre Rodríguez, J | 1 |
| Sanchez, F | 1 |
| Sotgiu, ML | 1 |
| Valente, M | 1 |
| Storchi, R | 1 |
| Caramenti, G | 1 |
| Biella, GE | 1 |
| Nordt, SP | 1 |
| Zilberstein, J | 1 |
| Gold, B | 1 |
| Connolly, I | 1 |
| Zaleon, C | 1 |
| Montagnini, M | 1 |
| Haroutiunian, S | 1 |
| Lipman, AG | 1 |
| Manfredi, PL | 1 |
| Foley, KM | 1 |
| Fayez, K | 1 |
| Juan-Diego, H | 1 |
| Oscar A, de LC | 1 |
| Colvin, L | 1 |
| Forbes, K | 1 |
| Fallon, M | 1 |
| Lemberg, K | 1 |
| Kontinen, VK | 1 |
| Viljakka, K | 1 |
| Kylänlahti, I | 1 |
| Yli-Kauhaluoma, J | 1 |
| Kalso, E | 1 |
| Martin, TJ | 1 |
| Kim, SA | 1 |
| Buechler, NL | 1 |
| Porreca, F | 1 |
| Eisenach, JC | 1 |
| Hamid, B | 1 |
| Haider, N | 1 |
| Gagnon, B | 1 |
| Altier, N | 1 |
| Dion, D | 1 |
| Boulanger, A | 1 |
| Choinière, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Methadone for 'Adenocarcinopathic' Pain Treatment: Methadone vs. Morphine Vanguard RCT[NCT05325164] | Phase 3 | 0 participants (Actual) | Interventional | 2022-09-30 | Withdrawn (stopped due to Trial not started; change in Sponsor and Principal Investigator, trial to be registered again by new Sponsor/Investigator if it is started.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for methadone and Neuralgia
| Article | Year |
|---|---|
Sigma-1 receptor antagonists: promising players in fighting neuropathic pain.
Topics: Analgesics, Opioid; Animals; Humans; Methadone; Narcotic Antagonists; Neuralgia; Nortriptyline; Pate | 2020 |
Methadone in Pain Management: A Systematic Review.
Topics: Analgesics, Opioid; Cancer Pain; Humans; Methadone; Neuralgia; Nociceptive Pain; Outcome Assessment, | 2021 |
Methadone for neuropathic pain in adults.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Humans; Methadone; Neuralgia; Pain Measurement; Patie | 2017 |
Management of severe neuropathic cancer pain: an illustrative case and review.
Topics: Aged; Analgesics, Opioid; Anticonvulsants; Drug Therapy, Combination; Head and Neck Neoplasms; Human | 2013 |
Methadone for chronic non-cancer pain in adults.
Topics: Adult; Analgesics, Opioid; Chronic Pain; Humans; Methadone; Neuralgia; Neuralgia, Postherpetic; Rand | 2012 |
Difficult pain.
Topics: Acupuncture; Analgesia; Analgesics, Opioid; Forecasting; Humans; Methadone; Nervous System Diseases; | 2006 |
3 trials available for methadone and Neuralgia
| Article | Year |
|---|---|
Management of Neuropathic Chronic Pain with Methadone Combined with Ketamine: A Randomized, Double Blind, Active-Controlled Clinical Trial.
Topics: Adult; Aged; Chronic Pain; Double-Blind Method; Female; Humans; Ketamine; Male; Methadone; Middle Ag | 2017 |
Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer.
Topics: Adult; Aged; Analgesics, Opioid; Cancer Pain; Female; Fentanyl; Head and Neck Neoplasms; Humans; Mal | 2016 |
Differences in the ratios of morphine to methadone in patients with neuropathic pain versus non-neuropathic pain.
Topics: Adult; Aged; Analgesics, Opioid; Drug Administration Schedule; Female; Humans; Male; Methadone; Midd | 1999 |
26 other studies available for methadone and Neuralgia
| Article | Year |
|---|---|
Tapentadol in Cancer Patients with Neuropathic Pain: A Comparison of Methadone, Oxycodone, Fentanyl, and Hydromorphone.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cancer Pain; Dose-Response Relationship, Drug; F | 2021 |
A Successful Case of Switching Treatment from Ketamine to Methadone for Complex Neuropathic Pain.
Topics: Activities of Daily Living; Analgesics, Opioid; Humans; Ketamine; Methadone; Neuralgia; Pain, Intrac | 2022 |
Rediscovery of Methadone to Improve Outcomes in Pain Management.
Topics: Analgesics, Opioid; Humans; Methadone; Neuralgia; Pain Management | 2022 |
Methadone rotation for cancer pain: an observational study.
Topics: Analgesics, Opioid; Cancer Pain; Humans; Methadone; Morphine; Neoplasms; Neuralgia | 2022 |
Oral Methadone for Patients With Neuropathic Pain Due to Neoplastic Brachial Plexopathy.
Topics: Analgesics, Opioid; Brachial Plexus Neuropathies; Head and Neck Neoplasms; Humans; Methadone; Neural | 2022 |
Very-Low-Dose Methadone To Treat Refractory Neuropathic Pain in Children with Cancer.
Topics: Amines; Analgesics; Analgesics, Opioid; Cancer Pain; Child; Child, Preschool; Chronic Pain; Cyclohex | 2017 |
Conservative Management of Neuropathic Pain in a Patient With Pancoast-Tobias Syndrome: A Case Report.
Topics: Analgesics, Opioid; Conservative Treatment; Female; Humans; Methadone; Middle Aged; Neuralgia; Panco | 2018 |
Neuropathic Pain in Pediatric Oncology: A Clinical Decision Algorithm.
Topics: Adult; Algorithms; Analgesics; Child; Chronic Pain; Clinical Decision-Making; Humans; Ketamine; Medi | 2019 |
Management of chronic neuropathic pain of different causes with the combination of oral methadone along with ketamine: A report of 18 cases.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Chronic Pain; Drug Combinations; Female; Humans; Ke | 2013 |
Rotating to oral methadone in advanced cancer patients: a case series.
Topics: Adult; Aged; Analgesics, Opioid; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Drug Ad | 2013 |
Methadone as an additional opioid for a cancer patient with severe neuropathic and bone pain not responsive to other opioids and adjuvant analgesics.
Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Buprenorphine; Drug Therapy, Co | 2013 |
Recombinant human growth hormone improves cognitive capacity in a pain patient exposed to chronic opioids.
Topics: Apoptosis; Arginine; Aspartic Acid; Cognition Disorders; Creatine; Growth Hormone; Growth Hormone-Re | 2014 |
Methadone for Patients with Malignant Psoas Syndrome: Case Series of Three Patients.
Topics: Adult; Aged; Analgesics, Opioid; Female; Humans; Male; Methadone; Middle Aged; Muscle Neoplasms; Neu | 2015 |
Use of Methadone as an Adjuvant Medication to Low-Dose Opioids for Neuropathic Pain in the Frail Elderly: A Case Series.
Topics: Aged; Analgesics; Analgesics, Opioid; Frail Elderly; Humans; Methadone; Neuralgia | 2016 |
Letter response: Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer.
Topics: Analgesics, Opioid; Fentanyl; Head and Neck Neoplasms; Humans; Methadone; Neuralgia; Pain; Pain Meas | 2016 |
Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer.
Topics: Analgesics, Opioid; Fentanyl; Head and Neck Neoplasms; Humans; Methadone; Neoplasms; Neuralgia; Pain | 2016 |
[Oral methadone for the management of difficult to control pain in Fabry disease].
Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Fabry Disease; Humans; Male; Methadone; Neural | 2018 |
Cooperative N-methyl-D-aspartate (NMDA) receptor antagonism and mu-opioid receptor agonism mediate the methadone inhibition of the spinal neuron pain-related hyperactivity in a rat model of neuropathic pain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Male; Methadone; Neuralgia; Neurons; Rats; Rats, Spra | 2009 |
Methadone-induced torsade de pointes.
Topics: Analgesics, Opioid; Humans; Male; Methadone; Middle Aged; Neuralgia; Torsades de Pointes | 2011 |
Opioids versus antidepressants in postherpetic neuralgia: a randomized, placebo-controlled trial.
Topics: Analgesics, Opioid; Herpes Zoster; Humans; Methadone; Morphine; Neuralgia; Neurotransmitter Uptake I | 2003 |
Opioids and chronic neuropathic pain.
Topics: Analgesics, Opioid; Chronic Disease; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Levor | 2003 |
Re: Methadone in the management of intractable neuropathic noncancer pain.
Topics: Analgesics, Opioid; Electrocardiography; Humans; Long QT Syndrome; Methadone; Neuralgia; Pain, Intra | 2006 |
Morphine, oxycodone, methadone and its enantiomers in different models of nociception in the rat.
Topics: Acute Disease; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Male; Methadone; Morph | 2006 |
Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics.
Topics: Adenosine; Analgesics, Opioid; Animals; Clonidine; Dose-Response Relationship, Drug; Fentanyl; Heroi | 2007 |
Spinal cord stimulator relieves neuropathic pain in a patient with radiation-induced transverse myelitis.
Topics: Analgesics, Opioid; Antidepressive Agents, Second-Generation; Carcinoma, Non-Small-Cell Lung; Combin | 2007 |
Successful use of methadone in the treatment of chronic neuropathic pain arising from burn injuries: a case-study.
Topics: Analgesics, Opioid; Burns; Chronic Disease; Humans; Leg Injuries; Male; Methadone; Middle Aged; Neur | 2001 |