methadone and Nausea
methadone has been researched along with Nausea in 14 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy of ondansetron 4 mg was compared with metoclopramide 10 mg for the prevention of post-operative nausea and vomiting in patients after major gynaecological abdominal surgery." | 9.08 | Comparison of ondansetron and metoclopramide for the prevention of post-operative nausea and vomiting after major gynaecological surgery. ( Chen, PP; Chui, PT; Gin, T, 1996) |
| "The efficacy of ondansetron 4 mg was compared with metoclopramide 10 mg for the prevention of post-operative nausea and vomiting in patients after major gynaecological abdominal surgery." | 5.08 | Comparison of ondansetron and metoclopramide for the prevention of post-operative nausea and vomiting after major gynaecological surgery. ( Chen, PP; Chui, PT; Gin, T, 1996) |
| " The most frequent treatment-emergent non-OWS adverse events were headache, nausea, constipation, and neck pain." | 2.82 | Switching Opioid-Dependent Patients From Methadone to Morphine: Safety, Tolerability, and Methadone Pharmacokinetics. ( Cape, G; Devane, J; Friedhoff, L; Glue, P; Gray, A; Harland, S; Howes, J; Hung, CT; Hung, N; Lam, F; Lockhart, M; Tunnicliff, D; Weis, H, 2016) |
| " Plasma concentrations and pharmacokinetic parameters of R- and S-methadone isomers were determined on days -1, 7, and 14 and of TMC125 on days 7 and 14." | 2.73 | Pharmacokinetic and pharmacodynamic study of the concomitant administration of methadone and TMC125 in HIV-negative volunteers. ( De Smedt, G; Hoetelmans, RM; Kakuda, TN; Peeters, M; Schöller-Gyüre, M; Stevens, T; van den Brink, W; Vanaken, H; Vandermeulen, K; Woodfall, B, 2008) |
| "IV-PCA provided timely, safe and useful analgesia for patients with severe breakthrough pain and may be useful to help titration of opioids, weaning to oral analgesia and to decide for interventional procedures." | 1.40 | Safety profile of intravenous patient-controlled analgesia for breakthrough pain in cancer patients: a case series study. ( Ashmawi, HA; Cascudo, GM; de Santana Neto, J; Guimaraes, GM; Neto, JO; Sousa, AM, 2014) |
| " The median elimination half-life of methadone in healthy subjects was 33-46 h depending on the method used to calculate this parameter." | 1.30 | The pharmacokinetics of methadone in healthy subjects and opiate users. ( Calvert, R; Feely, M; Hay, AW; Raistrick, D; Rostami-Hodjegan, A; Shires, S; Tucker, GT; Wolff, K, 1997) |
| "To assess the effect of opioid substitution (substituting one member of the opioid class for another) on the incidence and severity of adverse effects in palliative care patients who experience unacceptable, refractory adverse effects when taking an opioid drug." | 1.30 | Opioid substitution to reduce adverse effects in cancer pain management. ( Ashby, MA; Jackson, KA; Martin, P, 1999) |
Research
Studies (14)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (35.71) | 18.7374 |
| 1990's | 5 (35.71) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Sousa, AM | 1 |
| de Santana Neto, J | 1 |
| Guimaraes, GM | 1 |
| Cascudo, GM | 1 |
| Neto, JO | 1 |
| Ashmawi, HA | 1 |
| Glue, P | 1 |
| Cape, G | 1 |
| Tunnicliff, D | 1 |
| Lockhart, M | 1 |
| Lam, F | 1 |
| Gray, A | 1 |
| Hung, N | 1 |
| Hung, CT | 1 |
| Harland, S | 1 |
| Devane, J | 1 |
| Howes, J | 1 |
| Weis, H | 1 |
| Friedhoff, L | 1 |
| Russell, T | 1 |
| Mitchell, C | 1 |
| Paech, MJ | 1 |
| Pavy, T | 1 |
| Schöller-Gyüre, M | 1 |
| van den Brink, W | 1 |
| Kakuda, TN | 1 |
| Woodfall, B | 1 |
| De Smedt, G | 1 |
| Vanaken, H | 1 |
| Stevens, T | 1 |
| Peeters, M | 1 |
| Vandermeulen, K | 1 |
| Hoetelmans, RM | 1 |
| Haynes, SR | 1 |
| Davidson, I | 1 |
| Allsop, JR | 1 |
| Dutton, DA | 1 |
| Chen, PP | 1 |
| Chui, PT | 2 |
| Gin, T | 2 |
| Wolff, K | 1 |
| Rostami-Hodjegan, A | 1 |
| Shires, S | 1 |
| Hay, AW | 1 |
| Feely, M | 1 |
| Calvert, R | 1 |
| Raistrick, D | 1 |
| Tucker, GT | 1 |
| Ashby, MA | 1 |
| Martin, P | 1 |
| Jackson, KA | 1 |
| Grosz, HJ | 1 |
| Vandam, LD | 1 |
| Kerr, F | 1 |
| Donald, KW | 1 |
| Dundee, JW | 1 |
| Jones, PO | 1 |
| Tamarkin, NR | 1 |
| Goodwin, FK | 1 |
| Axelrod, J | 1 |
Clinical Trials (6)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Single-dose Intraoperative Methadone for Early Ambulation and Sustained Pain Control in Spinal Fusion Surgery Patients[NCT02989597] | Phase 4 | 10 participants (Actual) | Interventional | 2017-07-29 | Terminated (stopped due to Due to personnel loss and logistical issues the study was unable to be completed as planned.) | ||
| Study of the Efficiency of the Ketamine With Low Analgesic Doses, in Association With High Opioids, in the Treatment of the Rebels Pains, in Palliative Phase of the Cancerous Disease[NCT01326325] | Phase 3 | 24 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| Does Intraoperative Methadone Prevent Postoperative Pain in Bariatric Surgery?[NCT02775474] | Phase 4 | 32 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| Clinical Effectiveness and Safety of Intraoperative Methadone in Patients Undergoing Laparoscopic Hysterectomy: a Prospective, Double-blind, Randomised Controlled Trial[NCT03908060] | 126 participants (Actual) | Interventional | 2019-05-06 | Active, not recruiting | |||
| The Effect of Methadone on Perioperative Analgesia After Posterior Lumbar Fusion - A Randomized, Placebo-controlled, Double-blinded Study[NCT01125059] | 0 participants (Actual) | Interventional | 2010-05-31 | Withdrawn (stopped due to Unable to fulfill recruitment) | |||
| The Influence of Pharmacogenetics on Methadone Dose, Safety, and Outcomes After Spine Fusion[NCT01677650] | Phase 1 | 0 participants (Actual) | Interventional | 2014-03-31 | Withdrawn (stopped due to Investigator moved to new institution) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
2 reviews available for methadone and Nausea
| Article | Year |
|---|---|
Drug therapy: analgetic drugs--the potent analgetics.
Topics: Analgesics; Blood Circulation; Fentanyl; Humans; Intestines; Levallorphan; Meperidine; Methadone; Me | 1972 |
Editorial: Analgesia in myocardial infarction.
Topics: Analgesia; Analgesics; Animals; Blood Pressure; Cyclizine; Heart Arrest; Heroin; Humans; Injections, | 1974 |
Trials
7 trials available for methadone and Nausea
| Article | Year |
|---|---|
Switching Opioid-Dependent Patients From Methadone to Morphine: Safety, Tolerability, and Methadone Pharmacokinetics.
Topics: Adult; Analgesics, Opioid; Double-Blind Method; Drug Substitution; Female; Headache; Humans; Ibogain | 2016 |
Pharmacokinetic and pharmacodynamic study of the concomitant administration of methadone and TMC125 in HIV-negative volunteers.
Topics: Adult; Area Under Curve; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combinat | 2008 |
Comparison of epidural methadone with epidural diamorphine for analgesia following caesarean section.
Topics: Analgesia, Epidural; Analgesia, Obstetrical; Cesarean Section; Double-Blind Method; Female; Heroin; | 1993 |
Comparison of ondansetron and metoclopramide for the prevention of post-operative nausea and vomiting after major gynaecological surgery.
Topics: Adolescent; Adult; Analgesics, Opioid; Antiemetics; Double-Blind Method; Female; Humans; Hysterectom | 1996 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
Narcotic withdrawal symptoms in heroin users treated with propranolol.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Clinical Trials as Topic; Female; Heroin; Hu | 1972 |
The prevention of analgesic-induced nausea and vomiting by cyclizine.
Topics: Analgesia; Clinical Trials as Topic; Codeine; Cyclizine; Female; Humans; Levorphanol; Male; Meperidi | 1968 |
Other Studies
5 other studies available for methadone and Nausea
| Article | Year |
|---|---|
Safety profile of intravenous patient-controlled analgesia for breakthrough pain in cancer patients: a case series study.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Breakthrough Pain; Constipation; Female; Fentanyl; | 2014 |
Efficacy and safety of intraoperative intravenous methadone during general anaesthesia for caesarean delivery: a retrospective case-control study.
Topics: Adult; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Genera | 2013 |
The pharmacokinetics of methadone in healthy subjects and opiate users.
Topics: Adolescent; Adult; Biological Availability; Female; Half-Life; Humans; Male; Metabolic Clearance Rat | 1997 |
Opioid substitution to reduce adverse effects in cancer pain management.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Hospice Care; Humans; Male; Medical A | 1999 |
Rapid elevation of biogenic amine metabolites in human CSF following probenecid.
Topics: Administration, Oral; Affective Symptoms; Dihydroxyphenylalanine; Female; Headache; Humans; Hydroxyi | 1970 |