Page last updated: 2024-10-30

methadone and Nausea

methadone has been researched along with Nausea in 14 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.

Research Excerpts

ExcerptRelevanceReference
"The efficacy of ondansetron 4 mg was compared with metoclopramide 10 mg for the prevention of post-operative nausea and vomiting in patients after major gynaecological abdominal surgery."9.08Comparison of ondansetron and metoclopramide for the prevention of post-operative nausea and vomiting after major gynaecological surgery. ( Chen, PP; Chui, PT; Gin, T, 1996)
"The efficacy of ondansetron 4 mg was compared with metoclopramide 10 mg for the prevention of post-operative nausea and vomiting in patients after major gynaecological abdominal surgery."5.08Comparison of ondansetron and metoclopramide for the prevention of post-operative nausea and vomiting after major gynaecological surgery. ( Chen, PP; Chui, PT; Gin, T, 1996)
" The most frequent treatment-emergent non-OWS adverse events were headache, nausea, constipation, and neck pain."2.82Switching Opioid-Dependent Patients From Methadone to Morphine: Safety, Tolerability, and Methadone Pharmacokinetics. ( Cape, G; Devane, J; Friedhoff, L; Glue, P; Gray, A; Harland, S; Howes, J; Hung, CT; Hung, N; Lam, F; Lockhart, M; Tunnicliff, D; Weis, H, 2016)
" Plasma concentrations and pharmacokinetic parameters of R- and S-methadone isomers were determined on days -1, 7, and 14 and of TMC125 on days 7 and 14."2.73Pharmacokinetic and pharmacodynamic study of the concomitant administration of methadone and TMC125 in HIV-negative volunteers. ( De Smedt, G; Hoetelmans, RM; Kakuda, TN; Peeters, M; Schöller-Gyüre, M; Stevens, T; van den Brink, W; Vanaken, H; Vandermeulen, K; Woodfall, B, 2008)
"IV-PCA provided timely, safe and useful analgesia for patients with severe breakthrough pain and may be useful to help titration of opioids, weaning to oral analgesia and to decide for interventional procedures."1.40Safety profile of intravenous patient-controlled analgesia for breakthrough pain in cancer patients: a case series study. ( Ashmawi, HA; Cascudo, GM; de Santana Neto, J; Guimaraes, GM; Neto, JO; Sousa, AM, 2014)
" The median elimination half-life of methadone in healthy subjects was 33-46 h depending on the method used to calculate this parameter."1.30The pharmacokinetics of methadone in healthy subjects and opiate users. ( Calvert, R; Feely, M; Hay, AW; Raistrick, D; Rostami-Hodjegan, A; Shires, S; Tucker, GT; Wolff, K, 1997)
"To assess the effect of opioid substitution (substituting one member of the opioid class for another) on the incidence and severity of adverse effects in palliative care patients who experience unacceptable, refractory adverse effects when taking an opioid drug."1.30Opioid substitution to reduce adverse effects in cancer pain management. ( Ashby, MA; Jackson, KA; Martin, P, 1999)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19905 (35.71)18.7374
1990's5 (35.71)18.2507
2000's1 (7.14)29.6817
2010's3 (21.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sousa, AM1
de Santana Neto, J1
Guimaraes, GM1
Cascudo, GM1
Neto, JO1
Ashmawi, HA1
Glue, P1
Cape, G1
Tunnicliff, D1
Lockhart, M1
Lam, F1
Gray, A1
Hung, N1
Hung, CT1
Harland, S1
Devane, J1
Howes, J1
Weis, H1
Friedhoff, L1
Russell, T1
Mitchell, C1
Paech, MJ1
Pavy, T1
Schöller-Gyüre, M1
van den Brink, W1
Kakuda, TN1
Woodfall, B1
De Smedt, G1
Vanaken, H1
Stevens, T1
Peeters, M1
Vandermeulen, K1
Hoetelmans, RM1
Haynes, SR1
Davidson, I1
Allsop, JR1
Dutton, DA1
Chen, PP1
Chui, PT2
Gin, T2
Wolff, K1
Rostami-Hodjegan, A1
Shires, S1
Hay, AW1
Feely, M1
Calvert, R1
Raistrick, D1
Tucker, GT1
Ashby, MA1
Martin, P1
Jackson, KA1
Grosz, HJ1
Vandam, LD1
Kerr, F1
Donald, KW1
Dundee, JW1
Jones, PO1
Tamarkin, NR1
Goodwin, FK1
Axelrod, J1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Single-dose Intraoperative Methadone for Early Ambulation and Sustained Pain Control in Spinal Fusion Surgery Patients[NCT02989597]Phase 410 participants (Actual)Interventional2017-07-29Terminated (stopped due to Due to personnel loss and logistical issues the study was unable to be completed as planned.)
Study of the Efficiency of the Ketamine With Low Analgesic Doses, in Association With High Opioids, in the Treatment of the Rebels Pains, in Palliative Phase of the Cancerous Disease[NCT01326325]Phase 324 participants (Actual)Interventional2011-07-31Completed
Does Intraoperative Methadone Prevent Postoperative Pain in Bariatric Surgery?[NCT02775474]Phase 432 participants (Actual)Interventional2016-06-30Completed
Clinical Effectiveness and Safety of Intraoperative Methadone in Patients Undergoing Laparoscopic Hysterectomy: a Prospective, Double-blind, Randomised Controlled Trial[NCT03908060]126 participants (Actual)Interventional2019-05-06Active, not recruiting
The Effect of Methadone on Perioperative Analgesia After Posterior Lumbar Fusion - A Randomized, Placebo-controlled, Double-blinded Study[NCT01125059]0 participants (Actual)Interventional2010-05-31Withdrawn (stopped due to Unable to fulfill recruitment)
The Influence of Pharmacogenetics on Methadone Dose, Safety, and Outcomes After Spine Fusion[NCT01677650]Phase 10 participants (Actual)Interventional2014-03-31Withdrawn (stopped due to Investigator moved to new institution)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for methadone and Nausea

ArticleYear
Drug therapy: analgetic drugs--the potent analgetics.
    The New England journal of medicine, 1972, Feb-03, Volume: 286, Issue:5

    Topics: Analgesics; Blood Circulation; Fentanyl; Humans; Intestines; Levallorphan; Meperidine; Methadone; Me

1972
Editorial: Analgesia in myocardial infarction.
    British heart journal, 1974, Volume: 36, Issue:2

    Topics: Analgesia; Analgesics; Animals; Blood Pressure; Cyclizine; Heart Arrest; Heroin; Humans; Injections,

1974

Trials

7 trials available for methadone and Nausea

ArticleYear
Switching Opioid-Dependent Patients From Methadone to Morphine: Safety, Tolerability, and Methadone Pharmacokinetics.
    Journal of clinical pharmacology, 2016, Volume: 56, Issue:8

    Topics: Adult; Analgesics, Opioid; Double-Blind Method; Drug Substitution; Female; Headache; Humans; Ibogain

2016
Pharmacokinetic and pharmacodynamic study of the concomitant administration of methadone and TMC125 in HIV-negative volunteers.
    Journal of clinical pharmacology, 2008, Volume: 48, Issue:3

    Topics: Adult; Area Under Curve; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combinat

2008
Comparison of epidural methadone with epidural diamorphine for analgesia following caesarean section.
    Acta anaesthesiologica Scandinavica, 1993, Volume: 37, Issue:4

    Topics: Analgesia, Epidural; Analgesia, Obstetrical; Cesarean Section; Double-Blind Method; Female; Heroin;

1993
Comparison of ondansetron and metoclopramide for the prevention of post-operative nausea and vomiting after major gynaecological surgery.
    European journal of anaesthesiology, 1996, Volume: 13, Issue:5

    Topics: Adolescent; Adult; Analgesics, Opioid; Antiemetics; Double-Blind Method; Female; Humans; Hysterectom

1996
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave

1992
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave

1992
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave

1992
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave

1992
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave

1992
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave

1992
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave

1992
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave

1992
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave

1992
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave

1992
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave

1992
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave

1992
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave

1992
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave

1992
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave

1992
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:1

    Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave

1992
Narcotic withdrawal symptoms in heroin users treated with propranolol.
    Lancet (London, England), 1972, Sep-16, Volume: 2, Issue:7777

    Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Clinical Trials as Topic; Female; Heroin; Hu

1972
The prevention of analgesic-induced nausea and vomiting by cyclizine.
    The British journal of clinical practice, 1968, Volume: 22, Issue:9

    Topics: Analgesia; Clinical Trials as Topic; Codeine; Cyclizine; Female; Humans; Levorphanol; Male; Meperidi

1968

Other Studies

5 other studies available for methadone and Nausea

ArticleYear
Safety profile of intravenous patient-controlled analgesia for breakthrough pain in cancer patients: a case series study.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2014, Volume: 22, Issue:3

    Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Breakthrough Pain; Constipation; Female; Fentanyl;

2014
Efficacy and safety of intraoperative intravenous methadone during general anaesthesia for caesarean delivery: a retrospective case-control study.
    International journal of obstetric anesthesia, 2013, Volume: 22, Issue:1

    Topics: Adult; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Genera

2013
The pharmacokinetics of methadone in healthy subjects and opiate users.
    British journal of clinical pharmacology, 1997, Volume: 44, Issue:4

    Topics: Adolescent; Adult; Biological Availability; Female; Half-Life; Humans; Male; Metabolic Clearance Rat

1997
Opioid substitution to reduce adverse effects in cancer pain management.
    The Medical journal of Australia, 1999, Jan-18, Volume: 170, Issue:2

    Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Hospice Care; Humans; Male; Medical A

1999
Rapid elevation of biogenic amine metabolites in human CSF following probenecid.
    Life sciences. Pt. 1: Physiology and pharmacology, 1970, Dec-15, Volume: 9, Issue:24

    Topics: Administration, Oral; Affective Symptoms; Dihydroxyphenylalanine; Female; Headache; Humans; Hydroxyi

1970