Page last updated: 2024-10-30

methadone and Mood Disorders

methadone has been researched along with Mood Disorders in 20 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Mood Disorders: Those disorders that have a disturbance in mood as their predominant feature.

Research Excerpts

ExcerptRelevanceReference
"Methadone-maintained pregnant patients with mood disorders have compromised treatment outcomes ( [1] )."7.75The impact of mood disorders on the delivery and neonatal outcomes of methadone-maintained pregnant patients. ( Chisolm, MS; Fitzsimons, H; Heil, SH; Jones, HE; O'Grady, KE; Tuten, M, 2009)
"This study examines prevalence rates for DSM-III-R anxiety and affective disorders in three follow-up samples of opioid addicts who were treated with methadone maintenance."5.08Psychiatric comorbidity: prevalence in methadone maintenance treatment. ( Haas, N; Huggins, N; Khuder, S; McLellan, AT; Milby, JB; Schumacher, JE; Sims, MK; Woody, G, 1996)
" Dole DD-RG) patients according to the following six discussion points: (1) Treatment of personality disorders during Methadone Maintenance Treatment (MMT); (2) Treatment of Mood Disorders during MMT; (3) Treatment of Anxiety Disorders during MMT; (4) Treatment of Psychotic Disorders during MMT; (5) Treatment of violence during MMT; (6) Treatment of Alcohol Use Disorder (AUD) during MMT."5.01What we have learned from the Methadone Maintenance Treatment of Dual Disorder Heroin Use Disorder patients. ( Maremmani, AGI; Maremmani, I; Pacini, M, 2019)
"Methadone-maintained pregnant patients with mood disorders have compromised treatment outcomes ( [1] )."3.75The impact of mood disorders on the delivery and neonatal outcomes of methadone-maintained pregnant patients. ( Chisolm, MS; Fitzsimons, H; Heil, SH; Jones, HE; O'Grady, KE; Tuten, M, 2009)
"We report nine cases where fluoxetine (FX) (20 mg/day) was added to maintenance treatment with methadone (MTD) (dose range: 30-100 mg) in addicts with affective disorders."3.69Fluoxetine addition to methadone in addicts: pharmacokinetic aspects. ( Baumann, P; Bertschy, G; Eap, CB; Powell, K, 1996)
"This hyperalgesia is evident in people with a history of heroin use and is not modified by methadone or buprenorphine treatment but is reduced by long-term abstinence from opioids."1.32Pleasure into pain: the consequences of long-term opioid use. ( White, JM, 2004)
"Women with ASPD were unlikely to have alcohol use disorder, but likely to have opioid use disorder."1.30Gender differences in psychiatric comorbidity among cocaine-using opiate addicts. ( Foote, J; Handelsman, L; Kang, SY; Magura, S; Rosenblum, A, 1998)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19902 (10.00)18.7374
1990's6 (30.00)18.2507
2000's10 (50.00)29.6817
2010's2 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Maremmani, AGI1
Pacini, M2
Maremmani, I2
Treloar, C1
Holt, M1
Popovic, D1
Romano, A1
Maremmani, AG1
Perugi, G1
Deltito, J1
Akiskal, K1
Akiskal, H1
Tuten, M2
Heil, SH1
O'Grady, KE1
Fitzsimons, H1
Chisolm, MS1
Jones, HE2
Fischer, M1
Reif, A1
Polak, T1
Pfuhlmann, B1
Fallgatter, AJ1
White, JM2
Mitchell, TB1
Dyer, KR1
Newcombe, D1
Salter, A1
Somogyi, AA1
Bochner, F1
Seifert, J1
Metzner, C1
Paetzold, W1
Borsutzky, M1
Ohlmeier, M1
Passie, T1
Hauser, U1
Becker, H1
Wiese, B1
Emrich, H1
Schneider, U1
Rachid, F1
Golaz, J1
Bondolfi, G1
Bertschy, G3
Fitzsimons, HE1
Vaidya, V1
Shi, J1
Zhao, LY1
Epstein, DH1
Zhang, XL1
Lu, L1
Kanof, PD2
Aronson, MJ2
Ness, R2
Baumann, P2
Milby, JB1
Sims, MK1
Khuder, S1
Schumacher, JE1
Huggins, N1
McLellan, AT1
Woody, G1
Haas, N1
Eap, CB1
Powell, K1
Magura, S1
Kang, SY1
Rosenblum, A1
Handelsman, L2
Foote, J1
Calsyn, DA1
Wells, EA1
Fleming, C1
Saxon, AJ1
Cochrane, KJ1
Peachey, JE1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
MOms in REcovery (MORE): Defining Optimal Care for Pregnant Women and Infants[NCT04251208]444 participants (Actual)Observational2019-07-30Active, not recruiting
A Pilot Randomized Comparative Effectiveness Clinical Trial of Buprenorphine vs. Methadone for the Treatment of Opioid Dependence in Pregnancy.[NCT03098407]55 participants (Actual)Interventional2017-04-20Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for methadone and Mood Disorders

ArticleYear
What we have learned from the Methadone Maintenance Treatment of Dual Disorder Heroin Use Disorder patients.
    International journal of environmental research and public health, 2019, 02-03, Volume: 16, Issue:3

    Topics: Alcoholism; Antidepressive Agents; Antipsychotic Agents; Anxiety Disorders; Craving; Drug Interactio

2019

Trials

3 trials available for methadone and Mood Disorders

ArticleYear
Mood and affect during detoxification of opiate addicts: a comparison of buprenorphine versus methadone.
    Addiction biology, 2005, Volume: 10, Issue:2

    Topics: Adult; Anticonvulsants; Buprenorphine; Carbamazepine; Diagnostic and Statistical Manual of Mental Di

2005
Psychiatric comorbidity: prevalence in methadone maintenance treatment.
    The American journal of drug and alcohol abuse, 1996, Volume: 22, Issue:1

    Topics: Adult; Anxiety Disorders; Comorbidity; Female; Follow-Up Studies; Humans; Male; Methadone; Mood Diso

1996
The dysphoria of heroin addiction.
    The American journal of drug and alcohol abuse, 1992, Volume: 18, Issue:3

    Topics: Adolescent; Adult; Female; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Mood Disorders;

1992

Other Studies

16 other studies available for methadone and Mood Disorders

ArticleYear
Drug treatment clients' readiness for hepatitis C treatment: implications for expanding treatment services in drug and alcohol settings.
    Australian health review : a publication of the Australian Hospital Association, 2008, Volume: 32, Issue:3

    Topics: Adolescent; Adult; Female; Health Care Surveys; Health Knowledge, Attitudes, Practice; Hepatitis C;

2008
Affective temperaments in heroin addiction.
    Journal of affective disorders, 2009, Volume: 117, Issue:3

    Topics: Adult; Alcoholism; Anxiety Disorders; Bipolar Disorder; Cohort Studies; Comorbidity; Cyclothymic Dis

2009
The impact of mood disorders on the delivery and neonatal outcomes of methadone-maintained pregnant patients.
    The American journal of drug and alcohol abuse, 2009, Volume: 35, Issue:5

    Topics: Adult; Analysis of Variance; Chi-Square Distribution; Diagnosis, Dual (Psychiatry); Female; Genital

2009
The impact of mood disorders on the delivery and neonatal outcomes of methadone-maintained pregnant patients.
    The American journal of drug and alcohol abuse, 2009, Volume: 35, Issue:5

    Topics: Adult; Analysis of Variance; Chi-Square Distribution; Diagnosis, Dual (Psychiatry); Female; Genital

2009
The impact of mood disorders on the delivery and neonatal outcomes of methadone-maintained pregnant patients.
    The American journal of drug and alcohol abuse, 2009, Volume: 35, Issue:5

    Topics: Adult; Analysis of Variance; Chi-Square Distribution; Diagnosis, Dual (Psychiatry); Female; Genital

2009
The impact of mood disorders on the delivery and neonatal outcomes of methadone-maintained pregnant patients.
    The American journal of drug and alcohol abuse, 2009, Volume: 35, Issue:5

    Topics: Adult; Analysis of Variance; Chi-Square Distribution; Diagnosis, Dual (Psychiatry); Female; Genital

2009
False-positive methadone drug screens during quetiapine treatment.
    The Journal of clinical psychiatry, 2010, Volume: 71, Issue:12

    Topics: Adult; Antipsychotic Agents; Cross Reactions; Dibenzothiazepines; False Positive Reactions; Female;

2010
Pleasure into pain: the consequences of long-term opioid use.
    Addictive behaviors, 2004, Volume: 29, Issue:7

    Topics: Analgesics, Opioid; Drug Tolerance; Humans; Hyperalgesia; Methadone; Mood Disorders; Narcotics; Sens

2004
Subjective and physiological responses among racemic-methadone maintenance patients in relation to relative (S)- vs. (R)-methadone exposure.
    British journal of clinical pharmacology, 2004, Volume: 58, Issue:6

    Topics: Adult; Area Under Curve; Blood Pressure; Female; Heart Rate; Humans; Isomerism; Male; Methadone; Mid

2004
Induction of a mixed depressive episode during rTMS treatment in a patient with refractory major depression.
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2006, Volume: 7, Issue:4

    Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Antidepressive

2006
Mood disorders affect drug treatment success of drug-dependent pregnant women.
    Journal of substance abuse treatment, 2007, Volume: 32, Issue:1

    Topics: Adult; Diagnosis, Dual (Psychiatry); Diagnostic and Statistical Manual of Mental Disorders; Female;

2007
Long-term methadone maintenance reduces protracted symptoms of heroin abstinence and cue-induced craving in Chinese heroin abusers.
    Pharmacology, biochemistry, and behavior, 2007, Volume: 87, Issue:1

    Topics: Adult; Blood Pressure; China; Cues; Heart Rate; Heroin Dependence; Humans; Male; Methadone; Mood Dis

2007
Receptor physiology and hormone secretion in affective illness.
    Psychopharmacology bulletin, 1983, Volume: 19, Issue:3

    Topics: Acetylcholine; Antidepressive Agents; Biogenic Amines; Blood Platelets; Depression; Humans; Methadon

1983
Organic mood syndrome associated with detoxification from methadone maintenance.
    The American journal of psychiatry, 1993, Volume: 150, Issue:3

    Topics: Adult; Dose-Response Relationship, Drug; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Mo

1993
Vulnerability to fluoxetine-induced indifference syndrome among opiate addicts: a case report.
    Biological psychiatry, 1995, Sep-15, Volume: 38, Issue:6

    Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder; Fluoxetine; Humans; Male; Meth

1995
Fluoxetine addition to methadone in addicts: pharmacokinetic aspects.
    Therapeutic drug monitoring, 1996, Volume: 18, Issue:5

    Topics: Adult; Analgesics, Opioid; Antidepressive Agents, Second-Generation; Drug Interactions; Female; Fluo

1996
Gender differences in psychiatric comorbidity among cocaine-using opiate addicts.
    Journal of addictive diseases, 1998, Volume: 17, Issue:3

    Topics: Adult; Alcoholism; Anxiety Disorders; Cocaine-Related Disorders; Comorbidity; Female; Humans; Male;

1998
Changes in Millon Clinical Multiaxial Inventory scores among opiate addicts as a function of retention in methadone maintenance treatment and recent drug use.
    The American journal of drug and alcohol abuse, 2000, Volume: 26, Issue:2

    Topics: Adult; Antisocial Personality Disorder; Anxiety Disorders; Female; Follow-Up Studies; Humans; Male;

2000
The role of drugs in the treatment of opioid addicts.
    The Medical journal of Australia, 1986, Oct-20, Volume: 145, Issue:8

    Topics: Alcoholism; Anxiety; Clonidine; Dextropropoxyphene; Heroin; Humans; Inactivation, Metabolic; Kinetic

1986