methadone has been researched along with Long Sleeper Syndrome in 38 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study examined the cross-sectional associations among pain intensity, pain catastrophizing, and sleep disturbance among patients receiving methadone maintenance treatment (MMT) for opioid use disorder (OUD) and reporting co-occurring chronic pain." | 7.96 | Associations Among Sleep Disturbance, Pain Catastrophizing, and Pain Intensity for Methadone-maintained Patients With Opioid Use Disorder and Chronic Pain. ( Barry, DT; Beitel, M; Edwards, KA; Eller, A; Ponce Martinez, C; Roos, CR, 2020) |
| "The success of rehabilitation is not influenced solely by drug abstinence, but also by the state of general health and well-being, which for patients in methadone maintenance treatment (MMT) frequently is compromised by experiencing pain, depression and sleep disorders." | 7.78 | Pain depression and sleep disorders among methadone maintenance treatment patients. ( Lawental, E; Pud, D; Zlotnick, C, 2012) |
| "Following the findings of perceived poor sleep and of chronic pain among former heroin addicts, current methadone maintenance treatment (MMT) patients, and its possible relation to methadone dose, we studied these patients' objective sleep parameters." | 7.75 | Documented poor sleep among methadone-maintained patients is associated with chronic pain and benzodiazepine abuse, but not with methadone dose. ( Adelson, M; Peles, E; Schreiber, S, 2009) |
| "Poor sleep is a major complaint of people with human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) and undergoing methadone maintenance therapy (MMT)." | 5.34 | Effects of treatment of sleep disorders on sleep, psychological and cognitive functioning and biomarkers in individuals with HIV/AIDS and under methadone maintenance therapy. ( Alikhani, M; Brand, S; Davarinejad, O; Dürsteler, K; Ebrahimi, A; Farnia, V; Khazaie, H; Mohamadi, E; Radmehr, F; Sadeghi Bahmani, D, 2020) |
| "Methadone maintenance treatment (MMT) might be associated with the symptoms of depression and anxiety, sleep disturbances and sexual dysfunctions." | 5.30 | The effects of crocin on psychological parameters in patients under methadone maintenance treatment: a randomized clinical trial. ( Asemi, Z; Banafshe, HR; Ghaderi, A; Khalatbari-Mohseni, A; Mirhosseini, N; Omidi, A, 2019) |
| "This study examined the cross-sectional associations among pain intensity, pain catastrophizing, and sleep disturbance among patients receiving methadone maintenance treatment (MMT) for opioid use disorder (OUD) and reporting co-occurring chronic pain." | 3.96 | Associations Among Sleep Disturbance, Pain Catastrophizing, and Pain Intensity for Methadone-maintained Patients With Opioid Use Disorder and Chronic Pain. ( Barry, DT; Beitel, M; Edwards, KA; Eller, A; Ponce Martinez, C; Roos, CR, 2020) |
| "The success of rehabilitation is not influenced solely by drug abstinence, but also by the state of general health and well-being, which for patients in methadone maintenance treatment (MMT) frequently is compromised by experiencing pain, depression and sleep disorders." | 3.78 | Pain depression and sleep disorders among methadone maintenance treatment patients. ( Lawental, E; Pud, D; Zlotnick, C, 2012) |
| "Following the findings of perceived poor sleep and of chronic pain among former heroin addicts, current methadone maintenance treatment (MMT) patients, and its possible relation to methadone dose, we studied these patients' objective sleep parameters." | 3.75 | Documented poor sleep among methadone-maintained patients is associated with chronic pain and benzodiazepine abuse, but not with methadone dose. ( Adelson, M; Peles, E; Schreiber, S, 2009) |
| "Biofeedback was used as a means to relieve stress and anxiety for methadone patients." | 3.66 | Biofeedback application to drug addiction in the University of Colorado drug rehabilitation program. ( Brinkman, DN, 1978) |
| "Methadone maintenance treatment clinic." | 2.73 | Melatonin for perceived sleep disturbances associated with benzodiazepine withdrawal among patients in methadone maintenance treatment: a double-blind randomized clinical trial. ( Adelson, M; Bar-Hamburger, R; Hetzroni, T; Peles, E; Schreiber, S, 2007) |
| " There was credible evidence of a strong relationship between opioids and SDB with noted risk factors including use of methadone, high opioid dosing (>200 mg MED) and combining opioids with benzodiazepines." | 2.52 | Opioid Therapy and Sleep Disorders: Risks and Mitigation Strategies. ( Cheatle, MD; Webster, LR, 2015) |
| "Methadone maintenance treatment (MMT) has been shown to be an effective therapeutic strategy for opioid users." | 1.48 | Factors affecting the dose of methadone among patients receiving methadone maintenance therapy in Taiwan. ( Chung, KS; Hsu, CY; Li, DJ; Wu, HC; Yen, CF, 2018) |
| "Heroin abuse is a major public health problem with high morbidity and mortality." | 1.37 | Sleeping problems among Chinese heroin-dependent individuals. ( Chen, X; Hao, W; Liao, Y; Liu, T; Luo, T; Tang, J, 2011) |
| "Our objectives were to: (1) characterize obstructive sleep apnea (OSA) and CSA in patients in methadone maintenance treatment (MMT) for opioid dependence; (2) examine factors associated with SDB in this population; and (3) investigate whether SDB was related to severity of subjective sleep complaints in MMT patients with subjective sleep disturbances." | 1.36 | Obstructive sleep apnea is more common than central sleep apnea in methadone maintenance patients with subjective sleep complaints. ( Anderson, BJ; Corso, RP; Kurth, ME; Millman, RP; Sharkey, KM; Stein, MD, 2010) |
| "The SOWS measures withdrawal symptoms at the time of assessment." | 1.34 | Psychometric evaluation of the Dutch version of the Subjective Opiate Withdrawal Scale (SOWS). ( De Jong, CA; Dijkstra, BA; Krabbe, PF; Riezebos, TG; van der Staak, CP, 2007) |
| "Methadone serum levels were available in 55 patients, assessed by Gas Chromatography Mass Spectroscopy." | 1.33 | Variables associated with perceived sleep disorders in methadone maintenance treatment (MMT) patients. ( Adelson, M; Peles, E; Schreiber, S, 2006) |
| "Three patients with restless legs syndrome, two of whom also had nocturnal myoclonus, responded well to treatment with low doses of opioids." | 1.27 | Response to opioids in three patients with restless legs syndrome. ( Sateia, MJ; Trzepacz, PT; Violette, EJ, 1984) |
| "The restless legs syndrome is a sensory and motor disorder of evening, repose, and sleep." | 1.27 | Dominantly inherited restless legs with myoclonus and periodic movements of sleep: a syndrome related to the endogenous opiates? ( Côté, L; Fahn, S; Hening, W; Walters, A, 1986) |
| " Nocturnal sleep was not markedly altered during the chronic administration of methadone." | 1.25 | Human sleep and EEG through a cycle of methadone dependence. ( Kay, DC, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (21.05) | 18.7374 |
| 1990's | 1 (2.63) | 18.2507 |
| 2000's | 8 (21.05) | 29.6817 |
| 2010's | 17 (44.74) | 24.3611 |
| 2020's | 4 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Bertz, JW | 1 |
| Epstein, DH | 3 |
| Reamer, D | 1 |
| Kowalczyk, WJ | 2 |
| Phillips, KA | 2 |
| Kennedy, AP | 1 |
| Jobes, ML | 1 |
| Ward, G | 1 |
| Plitnick, BA | 1 |
| Figueiro, MG | 1 |
| Rea, MS | 1 |
| Preston, KL | 2 |
| Le, TA | 1 |
| Dang, AD | 1 |
| Tran, AHT | 1 |
| Nguyen, LH | 1 |
| Nguyen, THT | 1 |
| Phan, HT | 1 |
| Latkin, CA | 1 |
| Tran, BX | 1 |
| Ho, CSH | 1 |
| Ho, RCM | 1 |
| Finan, PH | 2 |
| Mun, CJ | 1 |
| Agage, D | 1 |
| Smith, MT | 1 |
| Tripathi, R | 1 |
| Rao, R | 1 |
| Dhawan, A | 1 |
| Jain, R | 1 |
| Sinha, S | 1 |
| Ponce Martinez, C | 1 |
| Edwards, KA | 1 |
| Roos, CR | 1 |
| Beitel, M | 1 |
| Eller, A | 1 |
| Barry, DT | 1 |
| Alikhani, M | 1 |
| Ebrahimi, A | 1 |
| Farnia, V | 1 |
| Khazaie, H | 1 |
| Radmehr, F | 1 |
| Mohamadi, E | 1 |
| Davarinejad, O | 1 |
| Dürsteler, K | 1 |
| Sadeghi Bahmani, D | 1 |
| Brand, S | 1 |
| Peles, E | 4 |
| Hacohen, S | 1 |
| Sason, A | 1 |
| Lamberg, S | 1 |
| Schrieber, S | 1 |
| Adelson, M | 4 |
| Dunn, KE | 1 |
| Andrew Tompkins, D | 1 |
| Strain, EC | 1 |
| Li, DJ | 1 |
| Chung, KS | 1 |
| Wu, HC | 1 |
| Hsu, CY | 1 |
| Yen, CF | 1 |
| Khalatbari-Mohseni, A | 1 |
| Banafshe, HR | 2 |
| Mirhosseini, N | 1 |
| Asemi, Z | 1 |
| Ghaderi, A | 2 |
| Omidi, A | 1 |
| Javdan, NS | 1 |
| Ghoreishi, FS | 1 |
| Sehat, M | 1 |
| Cheatle, MD | 1 |
| Webster, LR | 1 |
| Nordmann, S | 1 |
| Lions, C | 1 |
| Vilotitch, A | 1 |
| Michel, L | 1 |
| Mora, M | 1 |
| Spire, B | 1 |
| Maradan, G | 1 |
| Morel, A | 1 |
| Roux, P | 1 |
| Carrieri, MP | 1 |
| Zahari, Z | 1 |
| Inrahim, MA | 1 |
| Tan, SC | 1 |
| Mohamad, N | 1 |
| Ismail, R | 1 |
| Schreiber, S | 3 |
| Sharkey, KM | 4 |
| Kurth, ME | 4 |
| Corso, RP | 4 |
| Brower, KJ | 1 |
| Millman, RP | 4 |
| Stein, MD | 5 |
| Anderson, BJ | 4 |
| Xiao, L | 1 |
| Tang, YL | 1 |
| Smith, AK | 1 |
| Xiang, YT | 1 |
| Sheng, LX | 1 |
| Chi, Y | 1 |
| Du, WJ | 1 |
| Guo, S | 1 |
| Jiang, ZN | 1 |
| Zhang, GF | 1 |
| Luo, XN | 1 |
| Vecchierini, MF | 1 |
| Laaban, JP | 1 |
| Desjobert, M | 1 |
| Gagnadoux, F | 1 |
| Chabolle, F | 1 |
| Meurice, JC | 1 |
| Sapène, M | 1 |
| Serrier, P | 1 |
| Lévy, P | 1 |
| Liao, Y | 1 |
| Tang, J | 1 |
| Liu, T | 1 |
| Chen, X | 1 |
| Luo, T | 1 |
| Hao, W | 1 |
| Pud, D | 1 |
| Zlotnick, C | 1 |
| Lawental, E | 1 |
| Beswick, T | 1 |
| Best, D | 1 |
| Rees, S | 1 |
| Bearn, J | 1 |
| Gossop, M | 1 |
| Strang, J | 1 |
| Herman, DS | 1 |
| Bishop, S | 1 |
| Lassor, JA | 1 |
| Weinstock, M | 1 |
| Anthony, J | 1 |
| Dijkstra, BA | 1 |
| Krabbe, PF | 1 |
| Riezebos, TG | 1 |
| van der Staak, CP | 1 |
| De Jong, CA | 1 |
| Shi, J | 1 |
| Zhao, LY | 1 |
| Zhang, XL | 1 |
| Lu, L | 1 |
| Hetzroni, T | 1 |
| Bar-Hamburger, R | 1 |
| Trzepacz, PT | 1 |
| Violette, EJ | 1 |
| Sateia, MJ | 1 |
| Oyefeso, A | 1 |
| Sedgwick, P | 1 |
| Ghodse, H | 1 |
| Kay, DC | 1 |
| Brinkman, DN | 1 |
| Gomez, E | 1 |
| Mikhail, AR | 1 |
| Zelson, C | 1 |
| Davis, MM | 1 |
| Shanks, B | 1 |
| Mintz, J | 1 |
| O'Brien, CP | 1 |
| O'Hare, K | 1 |
| Goldschmidt, J | 1 |
| Walters, A | 1 |
| Hening, W | 1 |
| Côté, L | 1 |
| Fahn, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pomegranate Juice Consumption by Patients Under Medication for Addiction Treatment as a Regulator of Craving and Blood Redox Status: The Study Protocol of a Randomized Control Trial (the NUTRIDOPE Study)[NCT05861544] | 58 participants (Anticipated) | Interventional | 2023-03-23 | Enrolling by invitation | |||
| Behavioral Intervention to Improve Insomnia Symptoms in Patients With Opioid Use Disorder[NCT05588726] | 0 participants (Actual) | Interventional | 2022-01-01 | Withdrawn (stopped due to Staff no longer available to continue enrollment and other research activities) | |||
| [NCT00261183] | Phase 3 | 100 participants | Interventional | 2004-12-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for methadone and Long Sleeper Syndrome
| Article | Year |
|---|---|
Opioids and sleep - a review of literature.
Topics: Analgesics, Opioid; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Slee | 2020 |
Opioid Therapy and Sleep Disorders: Risks and Mitigation Strategies.
Topics: Analgesics, Opioid; Benzodiazepines; Chronic Pain; Drug Overdose; Humans; Methadone; Sleep Wake Diso | 2015 |
8 trials available for methadone and Long Sleeper Syndrome
| Article | Year |
|---|---|
Sleep reductions associated with illicit opioid use and clinic-hour changes during opioid agonist treatment for opioid dependence: Measurement by electronic diary and actigraphy.
Topics: Actigraphy; Adult; Ambulatory Care Facilities; Appointments and Schedules; Buprenorphine; Cross-Over | 2019 |
Effects of treatment of sleep disorders on sleep, psychological and cognitive functioning and biomarkers in individuals with HIV/AIDS and under methadone maintenance therapy.
Topics: Acquired Immunodeficiency Syndrome; Adult; Biomarkers; Cognition; Humans; Male; Methadone; Sleep; Sl | 2020 |
The effects of crocin on psychological parameters in patients under methadone maintenance treatment: a randomized clinical trial.
Topics: Adult; Anxiety; Carotenoids; Depression; Double-Blind Method; Drug Therapy, Combination; Humans; Met | 2019 |
Home polysomnography in methadone maintenance patients with subjective sleep complaints.
Topics: Adult; Analgesics, Opioid; Female; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders; P | 2009 |
Nocturnal sleep architecture disturbances in early methadone treatment patients.
Topics: Adult; Body Mass Index; Case-Control Studies; Humans; Linear Models; Male; Methadone; Narcotics; Opi | 2010 |
Trazodone for sleep disturbance during methadone maintenance: a double-blind, placebo-controlled trial.
Topics: Adult; Double-Blind Method; Female; Humans; Hypnotics and Sedatives; Male; Methadone; Narcotics; Opi | 2012 |
Melatonin for perceived sleep disturbances associated with benzodiazepine withdrawal among patients in methadone maintenance treatment: a double-blind randomized clinical trial.
Topics: Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Central Nervous System Depressants; Circad | 2007 |
Double-blind detoxification of methadone maintenance patients.
Topics: Administration, Oral; Adult; Consumer Behavior; Heroin Dependence; Humans; Methadone; Middle Aged; P | 1975 |
28 other studies available for methadone and Long Sleeper Syndrome
| Article | Year |
|---|---|
Factors Associated with Sleep Disorders among Methadone-Maintained Drug Users in Vietnam.
Topics: Adult; Cross-Sectional Studies; Drug Users; Female; Humans; Male; Methadone; Opiate Substitution Tre | 2019 |
Multimodal assessment of sleep in men and women during treatment for opioid use disorder.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Cohort Studies; Ecological Momentary Assessment; Electroen | 2020 |
Associations Among Sleep Disturbance, Pain Catastrophizing, and Pain Intensity for Methadone-maintained Patients With Opioid Use Disorder and Chronic Pain.
Topics: Adult; Catastrophization; Chronic Pain; Cross-Sectional Studies; Female; Humans; Male; Methadone; Mi | 2020 |
Is a History of Sexual Abuse Related to Poor Sleep Among Former Opioid-Addicted Women With and Without Methadone Maintenance Treatment?
Topics: Adult; Adult Survivors of Child Abuse; Analgesics, Opioid; Female; Humans; Male; Methadone; Middle A | 2017 |
Frequency and correlates of sleep disturbance in methadone and buprenorphine-maintained patients.
Topics: Adult; Buprenorphine; Comorbidity; Female; Humans; Male; Methadone; Middle Aged; Opiate Substitution | 2018 |
Frequency and correlates of sleep disturbance in methadone and buprenorphine-maintained patients.
Topics: Adult; Buprenorphine; Comorbidity; Female; Humans; Male; Methadone; Middle Aged; Opiate Substitution | 2018 |
Frequency and correlates of sleep disturbance in methadone and buprenorphine-maintained patients.
Topics: Adult; Buprenorphine; Comorbidity; Female; Humans; Male; Methadone; Middle Aged; Opiate Substitution | 2018 |
Frequency and correlates of sleep disturbance in methadone and buprenorphine-maintained patients.
Topics: Adult; Buprenorphine; Comorbidity; Female; Humans; Male; Methadone; Middle Aged; Opiate Substitution | 2018 |
Factors affecting the dose of methadone among patients receiving methadone maintenance therapy in Taiwan.
Topics: Adult; Age Factors; Analgesics, Opioid; Cohort Studies; Comorbidity; Dose-Response Relationship, Dru | 2018 |
Mental health and cognitive function responses to quetiapine in patients with methamphetamine abuse under methadone maintenance treatment.
Topics: Adolescent; Adult; Aged; Amphetamine-Related Disorders; Antidepressive Agents; Cognition; Depression | 2019 |
A prospective, longitudinal study of sleep disturbance and comorbidity in opiate dependence (the ANRS Methaville study).
Topics: Adult; Analgesics, Opioid; Female; Humans; Longitudinal Studies; Male; Methadone; Narcotic Antagonis | 2016 |
Sleep quality in opioid-naive and opioid-dependent patientson methadone maintenance therapy in Malaysia.
Topics: Analgesics, Opioid; Humans; Malaysia; Male; Methadone; Opioid-Related Disorders; Sleep; Sleep Wake D | 2016 |
Documented poor sleep among methadone-maintained patients is associated with chronic pain and benzodiazepine abuse, but not with methadone dose.
Topics: Adult; Benzodiazepines; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Male; Met | 2009 |
Obstructive sleep apnea is more common than central sleep apnea in methadone maintenance patients with subjective sleep complaints.
Topics: Adult; Body Mass Index; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Diso | 2010 |
Assessing sleep in opioid dependence: a comparison of subjective ratings, sleep diaries, and home polysomnography in methadone maintenance patients.
Topics: Adult; Female; Humans; Male; Medical Records; Methadone; Middle Aged; Opiate Substitution Treatment; | 2011 |
[Therapeutic strategies of obstructive sleep apnea syndrome integrating combined treatments?].
Topics: Alcohol Drinking; Benzodiazepines; Combined Modality Therapy; Continuous Positive Airway Pressure; E | 2010 |
Sleeping problems among Chinese heroin-dependent individuals.
Topics: Adult; Alcohol Drinking; Asian People; China; Female; Follow-Up Studies; Heroin Dependence; Humans; | 2011 |
Pain depression and sleep disorders among methadone maintenance treatment patients.
Topics: Adult; Analysis of Variance; Depressive Disorder; Female; Health Status; Humans; Male; Mental Health | 2012 |
Major disruptions of sleep during treatment of the opiate withdrawal syndrome: differences between methadone and lofexidine detoxification treatments.
Topics: Clonidine; Humans; Methadone; Narcotic Antagonists; Narcotics; Sleep Wake Disorders; Substance Withd | 2003 |
Sleep disturbances among methadone maintained patients.
Topics: Adult; Alcohol Drinking; Female; Humans; Least-Squares Analysis; Male; Methadone; Opioid-Related Dis | 2004 |
Variables associated with perceived sleep disorders in methadone maintenance treatment (MMT) patients.
Topics: Adult; Diagnostic and Statistical Manual of Mental Disorders; Female; Humans; Israel; Male; Methadon | 2006 |
Psychometric evaluation of the Dutch version of the Subjective Opiate Withdrawal Scale (SOWS).
Topics: Adult; Anxiety; Body Temperature; Body Temperature Regulation; Facial Expression; Heroin Dependence; | 2007 |
Long-term methadone maintenance reduces protracted symptoms of heroin abstinence and cue-induced craving in Chinese heroin abusers.
Topics: Adult; Blood Pressure; China; Cues; Heart Rate; Heroin Dependence; Humans; Male; Methadone; Mood Dis | 2007 |
Response to opioids in three patients with restless legs syndrome.
Topics: Codeine; Female; Humans; Male; Methadone; Middle Aged; Myoclonus; Oxycodone; Receptors, Opioid; Rest | 1984 |
Subjective sleep-wake parameters in treatment-seeking opiate addicts.
Topics: Adult; Circadian Rhythm; Female; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders; Pat | 1997 |
Human sleep and EEG through a cycle of methadone dependence.
Topics: Adult; Brain Diseases; Dreams; Electroencephalography; Fourier Analysis; Heroin Dependence; Humans; | 1975 |
Biofeedback application to drug addiction in the University of Colorado drug rehabilitation program.
Topics: Anxiety; Biofeedback, Psychology; Colorado; Costs and Cost Analysis; Electromyography; Heroin Depend | 1978 |
Treatment of methadone withdrawal with cerebral electrotherapy (electrosleep).
Topics: Adolescent; Adult; Anxiety; Electronarcosis; Evaluation Studies as Topic; Heroin Dependence; Humans; | 1979 |
Acute management of neonatal addiction.
Topics: Antidiarrheals; Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant | 1975 |
Neurological aspects of perinatal narcotic addiction and methadone treatment.
Topics: Auditory Perception; Autonomic Nervous System; Birth Weight; Central Nervous System Diseases; Child | 1975 |
Dominantly inherited restless legs with myoclonus and periodic movements of sleep: a syndrome related to the endogenous opiates?
Topics: Aged; Dextropropoxyphene; Electrocardiography; Electroencephalography; Electrooculography; Endorphin | 1986 |