methadone has been researched along with Long QT Syndrome in 132 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methadone has been associated with QTc prolongation and ventricular arrhythmias but the prevalence of QTc prolongation and association with ventricular arrhythmias remains unclear." | 7.81 | Methadone Therapy in Underserved Urban Community: QTc Prolongation and Life-Threatening Ventricular Arrhythmias. ( Cheng, A; Chowdhury, M; Khilkin, M; Palma, E; Wong, J, 2015) |
| "We conducted a prospective cohort study in a chronic pain clinic including 82 patients receiving methadone and 102 patients receiving non-methadone opioid therapy." | 7.81 | The QTc effect of low-dose methadone for chronic pain: a prospective pilot study. ( Ashburn, MA; Edson, E; Farrar, JT; Grodofsky, S; Hatchimonji, J; Huang, S; Lacy, K; Speck, RM, 2015) |
| "To assess the relative frequency of reporting of adverse events involving ventricular arrhythmia, cardiac arrest, corrected QT interval (QTc) prolongation or torsade de pointes to the US Food and Drug Administration (FDA) between buprenorphine and methadone." | 7.81 | Arrhythmia associated with buprenorphine and methadone reported to the Food and Drug Administration. ( Haigney, MC; Kao, DP; Krantz, MJ; Mehler, PS, 2015) |
| "High-dose methadone has been associated with rate-corrected QT (QTc) prolongation and 'torsade de pointes'." | 7.77 | Methadone maintenance, QTc and torsade de pointes: who needs an electrocardiogram and what is the prevalence of QTc prolongation? ( Gossop, M; Lintzeris, N; Markides, V; Mayet, S; Strang, J, 2011) |
| "Methadone is associated with QT prolongation and higher reporting of syncope in a population of heroin addicts." | 7.74 | Syncope and QT prolongation among patients treated with methadone for heroin dependence in the city of Copenhagen. ( Ege, P; Fanoe, S; Hvidt, C; Jensen, GB, 2007) |
| "Outpatient pain management center and methadone maintenance treatment programs." | 7.72 | Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes. ( Krantz, MJ; Kutinsky, IB; Mehler, PS; Robertson, AD, 2003) |
| "Methadone is a synthetic opioid frequently used in drug maintenance programs for heroin addicts." | 6.43 | Methadone-induced Torsade de pointes tachycardias. ( Ammann, P; Maeder, M; Osswald, S; Schaer, BA; Sticherling, C, 2005) |
| "Methadone can cause a prolonged QTc interval that can lead to ventricular arrhythmias." | 5.46 | The frequency of QTc prolongation among pediatric and young adult patients receiving methadone for cancer pain. ( Bruera, E; Liu, D; Madden, K; Park, M, 2017) |
| "Drug-induced long QT syndrome is a serious adverse drug reaction." | 5.33 | Drug-induced long QT syndrome in injection drug users receiving methadone: high frequency in hospitalized patients and risk factors. ( Broers, B; Chabert, J; Dayer, P; Desmeules, JA; Ehret, GB; Gaspoz, JM; Gex-Fabry, M; Musset, T; Perrier, A; Piguet, V; Shah, D; Voide, C, 2006) |
| "The purpose of this study was to determine the effect of initiation of methadone on QTc interval in patients with cancer pain seen at the palliative care setting." | 5.14 | The effect of oral methadone on the QTc interval in advanced cancer patients: a prospective pilot study. ( Bruera, E; de la Cruz, M; El Osta, B; Hui, D; Palmer, JL; Reddy, S; Walker, P, 2010) |
| "Nearly 20 studies showed a prolonged QT interval secondary to methadone in patients exhibiting the following features: (1) patients with cardiac pathologies, notably bradycardia, congenital long QT interval, myocardial pathologies related to AIDS and electrolyte disturbances; (2) patients receiving concomitant treatment with substances known to prolong QT interval, such as psychoactive stimulants, narcoleptics, tricyclic antidepressants, antiarrhythmic agents, macrolids, quinolones, non diuretic hypokalemiants and certain corticoids; (3) patients receiving treatments that inhibit methadone's metabolism, particularly those that act on the cytochrome P450 3A4 such as SSRI, antifungal agents, some macrolids and some retroviral agents." | 4.88 | [Review of cases of prolonged QTC and wave burst arrhythmia in patients treated with methadone]. ( Berleur, MP; Kerbage, H; Laqueille, X; Richa, S; Scart-Gres, C, 2012) |
| "To examine the recent literature with regards to methadone, prolongation of the QT interval, torsade de pointes and the implications for palliative care clinicians." | 4.85 | Prolonged QT interval and methadone: implications for palliative care. ( Beattie, JM; Wilcock, A, 2009) |
| "To compare the risks of cardiac arrythmias, long QT syndrome and overall mortality between patients with opioid use disorders (OUD) who were prescribed methadone, buprenorphine or naltrexone." | 4.31 | Cardiac and mortality outcome differences between methadone, buprenorphine and naltrexone prescriptions in patients with an opioid use disorder. ( Berger, NA; Davis, PB; Kaelber, DC; Volkow, ND; Wang, L; Xu, R, 2023) |
| "The full potential of methadone maintenance treatment (MMT) is often limited by the large inter-individual variability in both pharmacokinetics (PK) and pharmacodynamics (PD), and by the risk of torsade de pointes, a severe adverse effect caused by QTc prolongation." | 4.12 | A genetic-based population PK/PD modeling of methadone in Chinese opiate dependence patients. ( Guo, D; Lou, X; Shi, S; Shu, Y; Tan, Z; Yang, H; Yu, L; Zhou, H, 2022) |
| "Electrocardiogram changes due to acute opioid toxicity in children are not common, although in the case of methadone poisoning, long QT interval and associated arrhythmias should be anticipated." | 4.02 | Electrocardiographic Changes in Children With Acute Opioid Poisoning: A Cross-Sectional Study. ( Arzanin, F; Chahkandi, T; Kafian Atary, S; Rabiee, N; Riasi, H; Salehi, F, 2021) |
| "The effect of methadone on corrected QT interval (QTc) in patients with cancer pain is not well-known." | 3.91 | Evaluation of QTc Interval Prolongation Among Patients With Cancer Using Enteral Methadone. ( Hartman, A; Kale, SS; Lehman, A; Lovell, AG; Protus, BM; Saphire, ML, 2019) |
| "Our study examined the frequency of QTc prolongation among pediatric and young adult patients starting methadone for cancer pain." | 3.91 | Corrected QT Interval Prolongation in Pediatric and Young Adult Patients on Methadone for Cancer-Related Pain. ( Bruera, E; Jo, E; Liu, D; Madden, K; Williams, JL, 2019) |
| "Methadone has been associated with QTc prolongation and ventricular arrhythmias but the prevalence of QTc prolongation and association with ventricular arrhythmias remains unclear." | 3.81 | Methadone Therapy in Underserved Urban Community: QTc Prolongation and Life-Threatening Ventricular Arrhythmias. ( Cheng, A; Chowdhury, M; Khilkin, M; Palma, E; Wong, J, 2015) |
| "To assess the relative frequency of reporting of adverse events involving ventricular arrhythmia, cardiac arrest, corrected QT interval (QTc) prolongation or torsade de pointes to the US Food and Drug Administration (FDA) between buprenorphine and methadone." | 3.81 | Arrhythmia associated with buprenorphine and methadone reported to the Food and Drug Administration. ( Haigney, MC; Kao, DP; Krantz, MJ; Mehler, PS, 2015) |
| "We conducted a prospective cohort study in a chronic pain clinic including 82 patients receiving methadone and 102 patients receiving non-methadone opioid therapy." | 3.81 | The QTc effect of low-dose methadone for chronic pain: a prospective pilot study. ( Ashburn, MA; Edson, E; Farrar, JT; Grodofsky, S; Hatchimonji, J; Huang, S; Lacy, K; Speck, RM, 2015) |
| "Corrected QT interval (QTc) prolongation is long considered as a predisposing factor for the occurrence of torsade de pointes (TdP) and sudden cardiac arrest in methadone maintenance treatment." | 3.80 | The correlation between prolonged corrected QT interval with the frequency of respiratory arrest, endotracheal intubation, and mortality in acute methadone overdose. ( Azizi, Z; Farsi, D; Hassanian-Moghaddam, H; Jamshidnejad, N; Mirafzal, A; Zehtabchi, S, 2014) |
| "1646 cases of ventricular arrhythmia or cardiac arrest and 379 cases of QTc prolongation or torsade de pointes were associated with methadone." | 3.79 | Trends in reporting methadone-associated cardiac arrhythmia, 1997-2011: an analysis of registry data. ( Bucher Bartelson, B; Dart, R; Kao, D; Katz, D; Khatri, V; Krantz, MJ; Mehler, PS, 2013) |
| "Illicit drugs such as cocaine, and methadone can induce acquired long QT syndrome." | 3.77 | Cardiovascular-associated disease in an addicted population: an observation study. ( Bignamini, E; Cappa, C; Compostino, R; De Vivo, E; Demarie, D; Ferro, S; Imazio, M; Marletta, G; Trinchero, R, 2011) |
| "High-dose methadone has been associated with rate-corrected QT (QTc) prolongation and 'torsade de pointes'." | 3.77 | Methadone maintenance, QTc and torsade de pointes: who needs an electrocardiogram and what is the prevalence of QTc prolongation? ( Gossop, M; Lintzeris, N; Markides, V; Mayet, S; Strang, J, 2011) |
| "Methadone is associated with prolongation of the corrected QT interval (QTc) and torsade de pointes in case series, cross sectional studies, a prospective cohort study, and one randomized trial." | 3.74 | Heterogeneous impact of methadone on the QTc interval: what are the practical implications? ( Krantz, MJ, 2008) |
| "Methadone is associated with QT prolongation and higher reporting of syncope in a population of heroin addicts." | 3.74 | Syncope and QT prolongation among patients treated with methadone for heroin dependence in the city of Copenhagen. ( Ege, P; Fanoe, S; Hvidt, C; Jensen, GB, 2007) |
| "A woman developed a prolonged QT interval and torsade de pointes while on methadone treatment for heroin addiction." | 3.73 | A twist on torsade: a prolonged QT interval on methadone. ( Hunt, SC; Lamont, P, 2006) |
| "Outpatient pain management center and methadone maintenance treatment programs." | 3.72 | Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes. ( Krantz, MJ; Kutinsky, IB; Mehler, PS; Robertson, AD, 2003) |
| "To reduce the risk of cardiac arrhythmias and to improve patient outcomes, consideration of accurate patient selection, concomitant medications, electrolyte monitoring, and vigilant ECG monitoring should be considered." | 2.82 | Effects of opioid receptor agonist and antagonist medications on electrocardiogram changes and presentation of cardiac arrhythmia: review article. ( Catanzaro, JN; Delisle, BP; Di Biase, L; Elayi, CS; Etaee, F; Komaki, A; Natale, A; Tobin, M; Vuppala, S, 2022) |
| "Methadone is a synthetic opioid frequently used in drug maintenance programs for heroin addicts." | 2.43 | Methadone-induced Torsade de pointes tachycardias. ( Ammann, P; Maeder, M; Osswald, S; Schaer, BA; Sticherling, C, 2005) |
| "Oral methadone is a feasible alternative to IV methadone for patients undergoing spine surgery regarding both pain scores and postoperative opioid consumption." | 1.91 | Comparison of oral versus intravenous methadone on postoperative pain and opioid use after adult spinal deformity surgery: A retrospective, non-inferiority analysis. ( Dunn, LK; Esfahani, K; Naik, BI; Tennant, W; Tsang, S, 2023) |
| "Methadone has been associated with prolongation of the QTc interval (QTc) on electrocardiogram (ECG)." | 1.62 | Effect of methadone on QTc in infants. ( Arora, G; Maurer, S; May, C; Miller, M; Riley, M; Shenk, J; Snyder, K, 2021) |
| "Methadone is an opioid commonly used for acute pain management in burn patients." | 1.56 | Risk Factors and Prevalence of QTc Prolongation in Adult Burn Patients Receiving Methadone. ( Boyd, AN; Hartman, BC; Hester, AM; Schoenle, MK; Sood, R; Walroth, TA, 2020) |
| " Guidelines on the safe use of methadone have limited applicability to children since their cardiac intervals differ from those of adults." | 1.56 | Methadone's Effect on Cardiac Repolarization: Safety in the PICU. ( Friedman, SD; Kovach, JR; Thompson, NE, 2020) |
| " Information on demographics, dosing of methadone, and the use of electrocardiograms (ECGs) was collected." | 1.51 | Attitudes, Beliefs, and Practices of Pediatric Palliative Care Physicians Regarding the Use of Methadone in Children With Advanced Cancer. ( Bruera, E; Liu, D; Madden, K, 2019) |
| " Both SNP-based and gene-based approaches were used, and we tested also the interaction of the top SNP with methadone dosage to predict the QTc length." | 1.51 | QT length during methadone maintenance treatment: gene × dose interaction. ( Bellivier, F; Bloch, V; Laplanche, JL; Lepine, JP; Marees, AT; Marie-Claire, C; Mouly, S; Naccache, F; Prince, N; Vorspan, F; Zerdazi, EH, 2019) |
| "Methadone can cause a prolonged QTc interval that can lead to ventricular arrhythmias." | 1.46 | The frequency of QTc prolongation among pediatric and young adult patients receiving methadone for cancer pain. ( Bruera, E; Liu, D; Madden, K; Park, M, 2017) |
| "Methadone is a widely used opioid agonist treatment associated with QT prolongation and torsades de pointes." | 1.46 | QT interval prolongation in opioid agonist treatment: analysis of continuous 12-lead electrocardiogram recordings. ( Brown, AL; Calver, L; Dunlop, AJ; Gill, A; Isbister, GK; Scott, AJ, 2017) |
| "Methadone maintenance treatment physicians normalized most episodes as outpatients, often in collaboration with patients' primary care physicians." | 1.46 | Long QTc During Methadone Maintenance: Contributors and Interventions Over 4 Years. ( Batres-Y-Carr, T; Thuras, P; Westermeyer, J; Yoon, G, 2017) |
| "Three were prescribed methadone for opiate dependence (80, 90 and 125 mg daily), one also with hypokalemia; one prescribed escitalopram with hypokalaemia/hypomagnesaemia; three more with hypokalaemia alone." | 1.46 | The prevalence of QT prolongation in a population of patients with substance use disorders. ( Brown, A; Dunlop, AJ; Isbister, GK; Sadler, C; Scott, AJ, 2017) |
| "We present a case of seizure activity in a woman in whom EKG led to a diagnosis of intermittent monomorphic and polymorphic ventricular tachycardia (torsades de pointes), highlighting the need for careful consideration of alternative causes of seizures, even in patients with known epilepsy." | 1.46 | Ventricular tachycardia and prolonged QT interval presenting as seizure-like activity. ( Mitchell, SH; Morris, SC; Wentlandt, M, 2017) |
| "Methadone dose/weight was moderately correlated with QTc, and independently associated with longer QTc at both 440 and 470 cut-offs." | 1.43 | Methadone maintenance dose/weight ratio, long QTc, and EKG screening. ( Adabag, S; Anand, V; Batres-Y-Carr, T; Thuras, P; Westermeyer, J; Yoon, G, 2016) |
| "Methadone was by far the leading medication implicated in the development of TdP and an independent predictor in both univariate and multivariate analyses despite the fact that it was not the most common QT-prolonging medication in our population." | 1.43 | Drug-induced torsades de pointes in an underserved urban population. Methadone: is there therapeutic equipoise? ( Baldinger, SH; Di Biase, L; Engstrom, K; Ferrick, KJ; Fisher, JD; Garcia, MJ; Golive, A; Goodman-Meza, D; Gross, J; Kim, S; Krumerman, A; Makkiya, M; Medrano, F; Rangasamy, S; Romero, J; Valencia, CR, 2016) |
| "The serum Cmin methadone level was 1124 nmol/L (range, 547-1581 nmol/L)." | 1.42 | Effects of Hemodialysis on Methadone Pharmacokinetics and QTc. ( Arnesen, M; Brørs, O; Gjesdal, K; Hullstein, I; Krajci, P; Kringen, M; Müller, LD; Opdal, MS; Sagedal, S; Sayed, K, 2015) |
| " In a linear regression model, longer QTc interval was associated with methadone dosage and with one genetic factor." | 1.40 | KCNH2 polymorphism and methadone dosage interact to enhance QT duration. ( Bloch, V; Curis, E; Deveaux, LL; Drici, MD; Hajj, A; Ksouda, K; Laplanche, JL; Lépine, JP; Messali, A; Mouly, S; Peoc'h, K; Prince, N; Scherrmann, JM; Vorspan, F, 2014) |
| " The primary reasons respondents did not utilize methadone included a lack of knowledge of methadone's pharmacodynamics (39%), effectiveness (39%), and/or dosing equivalence (34%)." | 1.39 | Attitudes and practices of pediatric oncologists regarding methadone use in the treatment of cancer-related pain: results of a North American Survey. ( Davies, D; Friebert, S; Kim, M; Roth, M; Wang, D; Zelcer, S, 2013) |
| "Sudden cardiac death was recorded in five patients, and torsade de pointes was recorded in seven other patients." | 1.39 | Drug-induced long QT in adult psychiatric inpatients: the 5-year cross-sectional ECG Screening Outcome in Psychiatry study. ( Berney, P; Dayer, P; Gaspoz, JM; Gex-Fabry, M; Girardin, FR; Shah, D, 2013) |
| "Being diagnosed with congestive heart failure and taking methadone were the only individual variables that showed a statistically significant association with a QTc prolongation > 500 ms." | 1.39 | Comparison of QTc interval prolongation for patients in methadone versus buprenorphine maintenance treatment: a 5-year follow-up. ( Blackinton Gale, R; Casarella, J; Drexler, K; Fareed, A; Patil, D; Scheinberg, K; Vayalapalli, S, 2013) |
| "1%, depending on definition applied) in patients receiving relatively low daily doses of methadone therapy, with no evidence of a dose-response relationship." | 1.38 | Increased incidence of QT interval prolongation in a population receiving lower doses of methadone maintenance therapy. ( Keenan, E; Kiernan, G; Mahon, NG; McCarthy, C; McGorrian, C; Roy, AK; Sweeney, B, 2012) |
| "Methadone treatment is a well-recognised cause of QT interval lengthening in adults." | 1.37 | Maternal methadone therapy increases QTc interval in newborn infants. ( Bhoyar, A; Ewer, AK; Holder, G; Hussain, T; Parikh, R, 2011) |
| "Methadone dose was reduced in five patients with improvement of QT interval and resolution of arrhythmia." | 1.36 | Ventricular arrhythmias in patients treated with methadone for opioid dependence. ( Hanon, S; Rosman, J; Schweitzer, P; Seewald, RM; Yang, F, 2010) |
| " Of the 140 patients treated at the clinic between 2002 and 2009, 85 were excluded from the study because they had been treated as guests (had been in treatment in other clinics but received methadone dosing temporarily from our clinic), were treated in the clinic for less than 6 months, or dropped out of treatment." | 1.36 | Onsite QTc interval screening for patients in methadone maintenance treatment. ( Amar, R; Byrd-Sellers, J; Casarella, J; Drexler, K; Fareed, A; Lutchman, TS; Smith-Cox, J; Vayalapalli, S, 2010) |
| "Methadone subjects were significantly (odds ratio of 7." | 1.35 | Electrocardiogram characteristics of methadone and buprenorphine maintained subjects. ( Athanasos, P; Compton, P; Farquharson, AL; Hay, J; Psaltis, P, 2008) |
| "Mean methadone dose was 170." | 1.34 | Corrected-QT intervals as related to methadone dose and serum level in methadone maintenance treatment (MMT) patients: a cross-sectional study. ( Adelson, M; Bodner, G; Kreek, MJ; Peles, E; Rados, V, 2007) |
| "Methadone treatment is a well recognised cause of QT interval lengthening in adults." | 1.34 | Maternal methadone may cause arrhythmias in neonates. ( Ewer, AK; Hussain, T, 2007) |
| "Oral methadone therapy is an effective and increasingly popular treatment for opioid dependency and chronic pain." | 1.34 | QTc prolongation and torsades de pointes associated with methadone therapy. ( Brooks, DE; Katz, KD; Routhier, DD, 2007) |
| "Methadone was subsequently shown to prolong the QT interval as well." | 1.34 | Physician awareness of the cardiac effects of methadone: results of a national survey. ( Bucher Bartelson, B; Krantz, MJ; Rowan, SB; Schmittner, J, 2007) |
| "(3) Methadone has a long plasma elimination half-life, and this poses a risk of accumulation." | 1.33 | Torsades de pointes with methadone. ( , 2005) |
| "Drug-induced long QT syndrome is a serious adverse drug reaction." | 1.33 | Drug-induced long QT syndrome in injection drug users receiving methadone: high frequency in hospitalized patients and risk factors. ( Broers, B; Chabert, J; Dayer, P; Desmeules, JA; Ehret, GB; Gaspoz, JM; Gex-Fabry, M; Musset, T; Perrier, A; Piguet, V; Shah, D; Voide, C, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 57 (43.18) | 29.6817 |
| 2010's | 63 (47.73) | 24.3611 |
| 2020's | 12 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Etaee, F | 1 |
| Tobin, M | 1 |
| Vuppala, S | 1 |
| Komaki, A | 1 |
| Delisle, BP | 1 |
| Di Biase, L | 2 |
| Catanzaro, JN | 1 |
| Natale, A | 1 |
| Elayi, CS | 1 |
| Guo, D | 1 |
| Tan, Z | 1 |
| Lou, X | 1 |
| Shi, S | 1 |
| Shu, Y | 1 |
| Zhou, H | 1 |
| Yu, L | 1 |
| Yang, H | 1 |
| Ryan, K | 1 |
| Benz, P | 1 |
| Zosel, A | 1 |
| Farkas, A | 1 |
| Theobald, J | 1 |
| Esfahani, K | 1 |
| Tennant, W | 1 |
| Tsang, S | 1 |
| Naik, BI | 1 |
| Dunn, LK | 1 |
| Wang, L | 1 |
| Volkow, ND | 1 |
| Berger, NA | 1 |
| Davis, PB | 1 |
| Kaelber, DC | 1 |
| Xu, R | 1 |
| Riasi, H | 1 |
| Rabiee, N | 1 |
| Chahkandi, T | 1 |
| Arzanin, F | 1 |
| Kafian Atary, S | 1 |
| Salehi, F | 1 |
| Walroth, TA | 3 |
| Boyd, AN | 1 |
| Hester, AM | 1 |
| Schoenle, MK | 1 |
| Hartman, BC | 1 |
| Sood, R | 1 |
| Friedman, SD | 1 |
| Kovach, JR | 1 |
| Thompson, NE | 1 |
| Titus-Lay, EN | 2 |
| Jaynes, HA | 2 |
| Tomaselli Muensterman, E | 2 |
| Ott, CA | 2 |
| Desta, Z | 1 |
| Williams, G | 2 |
| Moe, PR | 2 |
| Wilbrandt, M | 2 |
| Tisdale, JE | 2 |
| Snyder, K | 1 |
| Maurer, S | 1 |
| Riley, M | 1 |
| May, C | 1 |
| Miller, M | 1 |
| Shenk, J | 1 |
| Arora, G | 1 |
| Madden, K | 3 |
| Park, M | 1 |
| Liu, D | 3 |
| Bruera, E | 4 |
| Isbister, GK | 3 |
| Brown, AL | 1 |
| Gill, A | 1 |
| Scott, AJ | 2 |
| Calver, L | 2 |
| Dunlop, AJ | 3 |
| Mijatović, V | 1 |
| Samojlik, I | 1 |
| Petković, S | 1 |
| Vukmirović, S | 1 |
| Uvelin, A | 1 |
| Dickov, A | 1 |
| Westermeyer, J | 2 |
| Thuras, P | 2 |
| Yoon, G | 2 |
| Batres-Y-Carr, T | 2 |
| Mikkelsen, CR | 1 |
| Jornil, JR | 1 |
| Andersen, LV | 1 |
| Hasselstrøm, JB | 1 |
| Polak, S | 1 |
| Schwinghammer, AJ | 1 |
| Wilson, MD | 1 |
| Hall, BA | 1 |
| Zerdazi, EH | 1 |
| Vorspan, F | 2 |
| Marees, AT | 1 |
| Naccache, F | 1 |
| Lepine, JP | 2 |
| Laplanche, JL | 2 |
| Prince, N | 2 |
| Marie-Claire, C | 1 |
| Bellivier, F | 1 |
| Mouly, S | 2 |
| Bloch, V | 2 |
| Lovell, AG | 1 |
| Protus, BM | 1 |
| Saphire, ML | 1 |
| Kale, SS | 1 |
| Lehman, A | 1 |
| Hartman, A | 1 |
| Ramoz, N | 1 |
| Soroosh, D | 1 |
| Neamatshahi, M | 1 |
| Zarmehri, B | 1 |
| Nakhaee, S | 1 |
| Mehrpour, O | 1 |
| Schmith, VD | 1 |
| Curd, L | 1 |
| Lohmer, LRL | 1 |
| Laffont, CM | 1 |
| Andorn, A | 1 |
| Young, MA | 1 |
| Piccininni, JA | 1 |
| Killinger, JS | 1 |
| Hammad, HT | 1 |
| Gerber, LM | 1 |
| Dayton, JD | 1 |
| Jo, E | 1 |
| Williams, JL | 1 |
| Tamraz, B | 1 |
| Reisner, L | 1 |
| French, AL | 1 |
| King, ST | 1 |
| Fischl, MA | 1 |
| Ofotokun, I | 1 |
| Kashuba, A | 1 |
| Milam, J | 1 |
| Murphy, K | 1 |
| Augenbraun, M | 1 |
| Liu, C | 1 |
| Finley, PR | 1 |
| Aouizerat, B | 1 |
| Cocohoba, J | 1 |
| Gange, S | 1 |
| Bacchetti, P | 1 |
| Greenblatt, RM | 1 |
| Upadhya, B | 1 |
| Ntim, W | 1 |
| Brandon Stacey, R | 1 |
| Henderson, R | 1 |
| Leedy, D | 1 |
| O'Brien, FX | 1 |
| Knovich, MA | 1 |
| Kao, D | 2 |
| Bucher Bartelson, B | 2 |
| Khatri, V | 1 |
| Dart, R | 1 |
| Mehler, PS | 7 |
| Katz, D | 1 |
| Krantz, MJ | 13 |
| Fareed, A | 3 |
| Vayalapalli, S | 3 |
| Scheinberg, K | 2 |
| Gale, R | 1 |
| Casarella, J | 3 |
| Drexler, K | 3 |
| Vallecillo, G | 1 |
| Mojal, S | 1 |
| Roquer, A | 1 |
| Martinez, D | 1 |
| Rossi, P | 1 |
| Fonseca, F | 2 |
| Muga, R | 1 |
| Torrens, M | 2 |
| Mason, JW | 1 |
| Mercadante, S | 1 |
| Prestia, G | 1 |
| Adile, C | 1 |
| Casuccio, A | 1 |
| Hasnain, M | 1 |
| Vieweg, WV | 1 |
| Breden Crouse, EL | 1 |
| Hancox, JC | 1 |
| Patil, D | 1 |
| Blackinton Gale, R | 1 |
| Girardin, FR | 1 |
| Gex-Fabry, M | 2 |
| Berney, P | 1 |
| Shah, D | 2 |
| Gaspoz, JM | 2 |
| Dayer, P | 3 |
| Farsi, D | 1 |
| Mirafzal, A | 2 |
| Hassanian-Moghaddam, H | 2 |
| Azizi, Z | 1 |
| Jamshidnejad, N | 1 |
| Zehtabchi, S | 1 |
| Hajj, A | 1 |
| Ksouda, K | 1 |
| Peoc'h, K | 1 |
| Curis, E | 1 |
| Messali, A | 1 |
| Deveaux, LL | 1 |
| Scherrmann, JM | 1 |
| Drici, MD | 1 |
| Park, H | 1 |
| Collins, KM | 1 |
| Biary, R | 1 |
| Su, M | 1 |
| Grodofsky, S | 1 |
| Edson, E | 1 |
| Huang, S | 1 |
| Speck, RM | 1 |
| Hatchimonji, J | 1 |
| Lacy, K | 1 |
| Farrar, JT | 1 |
| Ashburn, MA | 1 |
| Chowdhury, M | 1 |
| Wong, J | 1 |
| Cheng, A | 1 |
| Khilkin, M | 1 |
| Palma, E | 1 |
| Opdal, MS | 1 |
| Arnesen, M | 1 |
| Müller, LD | 1 |
| Hullstein, I | 1 |
| Sayed, K | 1 |
| Brørs, O | 1 |
| Kringen, M | 1 |
| Sagedal, S | 1 |
| Gjesdal, K | 1 |
| Krajci, P | 1 |
| Kao, DP | 1 |
| Haigney, MC | 6 |
| Talebi, S | 1 |
| Azhir, A | 1 |
| Zuber, S | 1 |
| Soman, S | 1 |
| Visco, F | 1 |
| Totouom-Tangho, H | 1 |
| Kalantar, H | 1 |
| Worku Hassen, G | 1 |
| Romero, J | 1 |
| Baldinger, SH | 1 |
| Goodman-Meza, D | 1 |
| Engstrom, K | 1 |
| Valencia, CR | 1 |
| Golive, A | 1 |
| Medrano, F | 1 |
| Rangasamy, S | 1 |
| Makkiya, M | 1 |
| Fisher, JD | 1 |
| Gross, J | 1 |
| Krumerman, A | 1 |
| Kim, S | 1 |
| Garcia, MJ | 1 |
| Ferrick, KJ | 1 |
| Brown, A | 1 |
| Sadler, C | 1 |
| Cataldo, M | 1 |
| Krantz, M | 1 |
| Adabag, S | 1 |
| Anand, V | 1 |
| Glue, P | 1 |
| Cape, G | 1 |
| Tunnicliff, D | 1 |
| Lockhart, M | 1 |
| Lam, F | 1 |
| Hung, N | 1 |
| Hung, CT | 1 |
| Harland, S | 1 |
| Devane, J | 1 |
| Crockett, RS | 1 |
| Howes, J | 1 |
| Darpo, B | 1 |
| Zhou, M | 1 |
| Weis, H | 1 |
| Friedhoff, L | 1 |
| Wentlandt, M | 1 |
| Morris, SC | 1 |
| Mitchell, SH | 1 |
| Juba, KM | 1 |
| Khadem, TM | 1 |
| Hutchinson, DJ | 1 |
| Brown, JE | 1 |
| Kam, AJ | 1 |
| Manini, AF | 1 |
| Nelson, LS | 1 |
| Marti-Almor, J | 1 |
| Pastor, A | 1 |
| Cladellas, M | 1 |
| Farré, M | 1 |
| de la Torre, R | 1 |
| Athanasos, P | 1 |
| Farquharson, AL | 1 |
| Compton, P | 1 |
| Psaltis, P | 1 |
| Hay, J | 1 |
| Wieneke, H | 1 |
| Conrads, H | 1 |
| Wolstein, J | 1 |
| Breuckmann, F | 1 |
| Gastpar, M | 1 |
| Erbel, R | 1 |
| Scherbaum, N | 1 |
| Stringer, J | 1 |
| Welsh, C | 1 |
| Tommasello, A | 1 |
| Anchersen, K | 2 |
| Clausen, T | 2 |
| Gossop, M | 3 |
| Hansteen, V | 5 |
| Waal, H | 5 |
| George, S | 2 |
| Moreira, K | 1 |
| Fapohunda, M | 1 |
| Wilcock, A | 1 |
| Beattie, JM | 1 |
| Reddy, S | 1 |
| Hui, D | 1 |
| El Osta, B | 1 |
| de la Cruz, M | 1 |
| Walker, P | 1 |
| Palmer, JL | 1 |
| Hanon, S | 1 |
| Seewald, RM | 1 |
| Yang, F | 1 |
| Schweitzer, P | 1 |
| Rosman, J | 1 |
| Byrd-Sellers, J | 1 |
| Amar, R | 1 |
| Smith-Cox, J | 1 |
| Lutchman, TS | 1 |
| Byrne, A | 1 |
| Hallinan, R | 1 |
| Newman, RG | 1 |
| Heppe, DB | 1 |
| Perrin-Terrin, A | 1 |
| Pathak, A | 1 |
| Lapeyre-Mestre, M | 1 |
| Parikh, R | 1 |
| Hussain, T | 2 |
| Holder, G | 1 |
| Bhoyar, A | 1 |
| Ewer, AK | 2 |
| Demarie, D | 1 |
| Marletta, G | 1 |
| Imazio, M | 1 |
| Cappa, C | 1 |
| Ferro, S | 1 |
| Compostino, R | 1 |
| De Vivo, E | 1 |
| Trinchero, R | 1 |
| Bignamini, E | 1 |
| Mayet, S | 1 |
| Lintzeris, N | 1 |
| Markides, V | 1 |
| Strang, J | 1 |
| Miller, MA | 1 |
| Bhasin, K | 1 |
| Reddy, VY | 1 |
| d'Avila, A | 1 |
| Stimmel, B | 3 |
| Martin, JA | 1 |
| Campbell, A | 1 |
| Killip, T | 1 |
| Kotz, M | 1 |
| Kreek, MJ | 2 |
| McCarroll, BA | 1 |
| Mehta, D | 1 |
| Payte, JT | 1 |
| Taylor, T | 1 |
| Wilford, BB | 1 |
| Bart, G | 1 |
| Chang, KC | 1 |
| Huang, CL | 1 |
| Liang, HY | 1 |
| Chang, SS | 1 |
| Wang, YC | 1 |
| Liang, WM | 1 |
| Lane, HY | 1 |
| Chen, CH | 1 |
| Stephen Huang, SK | 1 |
| Roy, AK | 1 |
| McCarthy, C | 1 |
| Kiernan, G | 1 |
| McGorrian, C | 1 |
| Keenan, E | 1 |
| Mahon, NG | 1 |
| Sweeney, B | 1 |
| Florian, J | 1 |
| Garnett, CE | 1 |
| Nallani, SC | 1 |
| Rappaport, BA | 1 |
| Throckmorton, DC | 1 |
| Laqueille, X | 1 |
| Richa, S | 1 |
| Kerbage, H | 1 |
| Scart-Gres, C | 1 |
| Berleur, MP | 1 |
| Spevak, C | 1 |
| Hamsher, C | 1 |
| Brown, CQ | 1 |
| Wedam, EF | 1 |
| Stallvik, M | 1 |
| Nordstrand, B | 1 |
| Kristensen, Ø | 1 |
| Bathen, J | 2 |
| Skogvoll, E | 1 |
| Spigset, O | 2 |
| Roth, M | 1 |
| Davies, D | 1 |
| Friebert, S | 1 |
| Wang, D | 1 |
| Kim, M | 1 |
| Zelcer, S | 1 |
| Kutinsky, IB | 1 |
| Robertson, AD | 1 |
| Martell, BA | 2 |
| Arnsten, JH | 2 |
| Ray, B | 1 |
| Gourevitch, MN | 2 |
| Kornick, CA | 1 |
| Kilborn, MJ | 1 |
| Santiago-Palma, J | 1 |
| Schulman, G | 1 |
| Thaler, HT | 1 |
| Keefe, DL | 1 |
| Katchman, AN | 1 |
| Pezzullo, JC | 1 |
| Ebert, SN | 1 |
| Woosley, RL | 2 |
| Payne, R | 1 |
| Manfredi, PL | 1 |
| Gil, M | 1 |
| Sala, M | 1 |
| Anguera, I | 1 |
| Chapinal, O | 1 |
| Cervantes, M | 1 |
| Guma, JR | 1 |
| Segura, F | 1 |
| Decerf, JA | 1 |
| Gressens, B | 1 |
| Brohet, C | 1 |
| Liolios, A | 1 |
| Hantson, P | 1 |
| Lucchini, A | 1 |
| Barbaro, G | 1 |
| Barbarini, G | 1 |
| Piguet, V | 2 |
| Desmeules, J | 1 |
| Ehret, G | 1 |
| Stoller, R | 1 |
| Schmittner, J | 4 |
| Schroeder, JR | 1 |
| Epstein, DH | 1 |
| Preston, KL | 1 |
| Krook, AL | 3 |
| Hrovatin, E | 1 |
| Zardo, F | 1 |
| Brieda, M | 1 |
| Dametto, E | 1 |
| Piazza, R | 1 |
| Antonini-Canterin, F | 1 |
| Cassin, M | 1 |
| Meneguzzo, N | 1 |
| Viel, E | 1 |
| Lestuzzi, C | 1 |
| Di Gennaro, G | 1 |
| Nicolosi, GL | 1 |
| Maremmani, I | 1 |
| Pacini, M | 1 |
| Cesaroni, C | 1 |
| Lovrecic, M | 1 |
| Perugi, G | 1 |
| Tagliamonte, A | 1 |
| Pearson, EC | 1 |
| Sticherling, C | 1 |
| Schaer, BA | 1 |
| Ammann, P | 1 |
| Maeder, M | 1 |
| Osswald, S | 1 |
| Østvold, C | 1 |
| Topper, M | 1 |
| Rademacher, S | 1 |
| Dietz, R | 1 |
| Haverkamp, W | 1 |
| Fayez, K | 1 |
| Juan-Diego, H | 1 |
| Oscar A, de LC | 1 |
| Ehret, GB | 2 |
| Voide, C | 1 |
| Chabert, J | 1 |
| Broers, B | 2 |
| Musset, T | 1 |
| Perrier, A | 1 |
| Desmeules, JA | 2 |
| Chatterjee, B | 1 |
| Bürgi, U | 1 |
| Fredheim, OM | 1 |
| Borchgrevink, PC | 1 |
| Hegrenaes, L | 1 |
| Kaasa, S | 1 |
| Dale, O | 1 |
| Klepstad, P | 1 |
| Lamont, P | 1 |
| Hunt, SC | 1 |
| Baker, WA | 1 |
| Petrosillo, N | 1 |
| Lisena, FP | 1 |
| Chinello, P | 1 |
| Justo, D | 1 |
| Skjervold, B | 1 |
| Andersen, HT | 1 |
| Ekgren, JS | 1 |
| Peles, E | 1 |
| Bodner, G | 1 |
| Rados, V | 1 |
| Adelson, M | 1 |
| Eap, CB | 1 |
| Crettol, S | 1 |
| Rougier, JS | 1 |
| Schläpfer, J | 1 |
| Sintra Grilo, L | 1 |
| Déglon, JJ | 1 |
| Besson, J | 1 |
| Croquette-Krokar, M | 1 |
| Carrupt, PA | 1 |
| Abriel, H | 1 |
| Fanoe, S | 1 |
| Hvidt, C | 1 |
| Ege, P | 1 |
| Jensen, GB | 1 |
| Routhier, DD | 1 |
| Katz, KD | 1 |
| Brooks, DE | 1 |
| Le Page, L | 1 |
| Lion-Daolio, S | 1 |
| Guillaumont, MP | 1 |
| Grignon, P | 1 |
| Smail, A | 1 |
| Ducroix, JP | 1 |
| Al-Sardar, H | 1 |
| Sekine, R | 1 |
| Obbens, EA | 1 |
| Coyle, N | 1 |
| Inturrisi, CE | 1 |
| Rowan, SB | 1 |
| Wong, SC | 1 |
| Roberts, JR | 1 |
| Patel, AM | 1 |
| Singh, JP | 1 |
| Ruskin, JN | 1 |
| Cruciani, RA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Methadone-Induced QT Interval Prolongation in a Narcotic Treatment Center: Identifying Patients at Risk and Simplifying ECG Monitoring[NCT02898337] | 170 participants (Anticipated) | Observational | 2016-11-30 | Completed | |||
| Factors Associated With the Variance of Oral Methadone Dosage at Steady State of Maintenance Treatment: Description of Bio-markers of Phenotype and Genotype.[NCT00894452] | 210 participants (Actual) | Observational | 2008-12-31 | Completed | |||
| Influence of KCNH2 Polymorphisms on the QTc Interval in Kelantanese Malays Patients Receiving Methadone Maintenance Therapy (MMT) in Malaysia[NCT03603158] | 111 participants (Actual) | Observational | 2011-02-01 | Completed | |||
| Development and Evaluation of a Methadone Protocol for Severe Chronic Pain Management[NCT02335398] | Phase 4 | 34 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| An Open-label, Randomised Pilot Study Comparing the Efficacy, Safety and Tolerability of Raltegravir With Protease Inhibitor-based Therapy in Treatment-naïve, HIV/Hepatitis C Co-infected Injecting Drug Users Receiving Methadone[NCT01105611] | Phase 4 | 40 participants (Anticipated) | Interventional | 2010-08-31 | Recruiting | ||
| Opioid Switching From Oral Slow Release Morphine to Oral Methadone May Improve Pain Control in Chronic Non-malignant Pain: a Nine-month Follow-up Study.[NCT00356083] | Phase 3 | 12 participants (Actual) | Interventional | 2004-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for methadone and Long QT Syndrome
| Article | Year |
|---|---|
Effects of opioid receptor agonist and antagonist medications on electrocardiogram changes and presentation of cardiac arrhythmia: review article.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Electrocardiography; Humans; Long QT Syndrome; Methadone; | 2022 |
Methadone-associated Q-T interval prolongation and torsades de pointes.
Topics: Animals; Humans; Long QT Syndrome; Methadone; Risk Factors; Torsades de Pointes | 2009 |
Methadone and the heart: what the clinician needs to know.
Topics: Animals; Dose-Response Relationship, Drug; Female; Heart Conduction System; Humans; Infusions, Intra | 2008 |
Prolonged QT interval and methadone: implications for palliative care.
Topics: Female; Humans; Long QT Syndrome; Male; Methadone; Narcotics; Palliative Care; Patient Selection; To | 2009 |
[Review of cases of prolonged QTC and wave burst arrhythmia in patients treated with methadone].
Topics: Adult; Analgesics, Opioid; Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Drug Interactio | 2012 |
The clinical significance of QT interval prolongation in anesthesia and pain management: what you should and should not worry about.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Anesthetics, Inhalation; Droperidol; Humans; Long QT Synd | 2012 |
QT interval prolongation in patients on methadone with concomitant drugs.
Topics: Adult; Female; Humans; Long QT Syndrome; Male; Methadone | 2004 |
Methadone-induced Torsade de pointes tachycardias.
Topics: Adult; Analgesics, Opioid; Cocaine-Related Disorders; Electrocardiography; Female; Humans; Long QT S | 2005 |
Methadone-associated long QT syndrome: improving pharmacotherapy for dependence on illegal opioids and lessons learned for pharmacology.
Topics: Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Electr | 2007 |
Methadone: to ECG or not to ECG...That is still the question.
Topics: Clinical Trials as Topic; Electrocardiography; Incidence; Long QT Syndrome; Methadone; PubMed; Risk | 2008 |
6 trials available for methadone and Long QT Syndrome
| Article | Year |
|---|---|
Ascending Single-Dose, Double-Blind, Placebo-Controlled Safety Study of Noribogaine in Opioid-Dependent Patients.
Topics: Adult; Area Under Curve; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; | 2016 |
Levo-alpha-acetylmethadol (LAAM) induced QTc-prolongation - results from a controlled clinical trial.
Topics: Adult; Electrocardiography; Female; Heart Rate; Heroin Dependence; Humans; Long QT Syndrome; Male; M | 2009 |
The effect of oral methadone on the QTc interval in advanced cancer patients: a prospective pilot study.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relationship, Drug; Electrocardiog | 2010 |
QT interval prolongation: prevalence, risk factors and pharmacovigilance data among methadone-treated patients in France.
Topics: Adult; Death, Sudden; Death, Sudden, Cardiac; Female; France; Heart Diseases; Humans; Long QT Syndro | 2011 |
A modeling and simulation approach to characterize methadone QT prolongation using pooled data from five clinical trials in MMT patients.
Topics: Adult; Computer Simulation; Dose-Response Relationship, Drug; Female; Humans; Long QT Syndrome; Male | 2012 |
Opioid switching from morphine to methadone causes a minor but not clinically significant increase in QTc time: A prospective 9-month follow-up study.
Topics: Aged; Analgesics, Opioid; Drug Administration Schedule; Electrocardiography; Female; Follow-Up Studi | 2006 |
116 other studies available for methadone and Long QT Syndrome
| Article | Year |
|---|---|
A genetic-based population PK/PD modeling of methadone in Chinese opiate dependence patients.
Topics: China; Dose-Response Relationship, Drug; Electrocardiography; Humans; Long QT Syndrome; Methadone; O | 2022 |
QTc Prolongation in Poison Center Exposures to CredibleMeds List of Substances with "Known Risk of Torsades de Pointes".
Topics: Amitriptyline; Arrhythmias, Cardiac; Diphenhydramine; Electrocardiography; Flecainide; Humans; Long | 2022 |
Comparison of oral versus intravenous methadone on postoperative pain and opioid use after adult spinal deformity surgery: A retrospective, non-inferiority analysis.
Topics: Adult; Analgesics, Opioid; Cohort Studies; Humans; Long QT Syndrome; Methadone; Morphine; Opioid-Rel | 2023 |
Cardiac and mortality outcome differences between methadone, buprenorphine and naltrexone prescriptions in patients with an opioid use disorder.
Topics: Buprenorphine; Humans; Long QT Syndrome; Methadone; Naltrexone; Opiate Substitution Treatment; Opioi | 2023 |
Electrocardiographic Changes in Children With Acute Opioid Poisoning: A Cross-Sectional Study.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Child; Child, Preschool; Cross-Sectional Studies; Electroc | 2021 |
Risk Factors and Prevalence of QTc Prolongation in Adult Burn Patients Receiving Methadone.
Topics: Adult; Burns; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Indiana; Long Q | 2020 |
Methadone's Effect on Cardiac Repolarization: Safety in the PICU.
Topics: Adolescent; Adult; Child; Electrocardiography; Humans; Intensive Care Units, Pediatric; Long QT Synd | 2020 |
Methadone-associated QT interval prolongation in patients undergoing maintenance therapy in an urban opioid treatment program.
Topics: Adult; Female; Humans; Long QT Syndrome; Male; Methadone; Middle Aged; Opioid-Related Disorders; Pro | 2021 |
Effect of methadone on QTc in infants.
Topics: Analgesics, Opioid; Child; Electrocardiography; Humans; Infant; Long QT Syndrome; Methadone; Prospec | 2021 |
Accuracy of a single-lead mobile smartphone electrocardiogram for QT interval measurement in patients undergoing maintenance methadone therapy.
Topics: Adult; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Methadone; Middle Aged; Opioid-R | 2021 |
The frequency of QTc prolongation among pediatric and young adult patients receiving methadone for cancer pain.
Topics: Adolescent; Adult; Analgesics, Opioid; Cancer Pain; Child; Child, Preschool; Dose-Response Relations | 2017 |
QT interval prolongation in opioid agonist treatment: analysis of continuous 12-lead electrocardiogram recordings.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Dose-Response Relationship, Drug; Electrocardiography; Fem | 2017 |
Cardiovascular effects of methadone and concomitant use of diazepam during methadone maintenance treatment induction: low concentration risk.
Topics: Adult; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Electrocardiography; Female; H | 2017 |
Long QTc During Methadone Maintenance: Contributors and Interventions Over 4 Years.
Topics: Adult; Aged; Analgesics, Opioid; Electrocardiography; Humans; Long QT Syndrome; Male; Methadone; Mid | 2017 |
Utilizing postmortem drug concentrations in mechanistic modeling and simulation of cardiac effects: a proof of concept study with methadone.
Topics: Autopsy; Computer Simulation; Electrocardiography; Forensic Toxicology; Heart; Humans; Long QT Syndr | 2018 |
Corrected QT Interval Prolongation in Hospitalized Pediatric Patients Receiving Methadone.
Topics: Child; Child, Preschool; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Infa | 2018 |
QT length during methadone maintenance treatment: gene × dose interaction.
Topics: Adult; Dose-Response Relationship, Drug; Electrocardiography; Female; Genetic Predisposition to Dise | 2019 |
Evaluation of QTc Interval Prolongation Among Patients With Cancer Using Enteral Methadone.
Topics: Adult; Aged; Analgesics, Opioid; Cancer Pain; Dose-Response Relationship, Drug; Female; Humans; Long | 2019 |
Attitudes, Beliefs, and Practices of Pediatric Palliative Care Physicians Regarding the Use of Methadone in Children With Advanced Cancer.
Topics: Administration, Intravenous; Administration, Oral; Adult; Aged; Analgesics, Opioid; Cancer Pain; Chi | 2019 |
QT length during methadone maintenance treatment: Gene x dose interaction.
Topics: Electrocardiography; Humans; Long QT Syndrome; Methadone; Opiate Substitution Treatment; Pharmacogen | 2019 |
Drug-induced prolonged corrected QT interval in patients with methadone and opium overdose.
Topics: Adult; Analgesics, Opioid; Cross-Sectional Studies; Drug Overdose; Female; Humans; Iran; Long QT Syn | 2019 |
Evaluation of the Effects of a Monthly Buprenorphine Depot Subcutaneous Injection on QT Interval During Treatment for Opioid Use Disorder.
Topics: Adult; Age Factors; Aged; Barbiturates; Buprenorphine; Delayed-Action Preparations; Dose-Response Re | 2019 |
QT Interval Prolongation in the Pediatric Oncologic Population on Methadone.
Topics: Adolescent; Adult; Analgesics, Opioid; Cancer Pain; Child; Child, Preschool; Female; Follow-Up Studi | 2020 |
Corrected QT Interval Prolongation in Pediatric and Young Adult Patients on Methadone for Cancer-Related Pain.
Topics: Adolescent; Adult; Age Factors; Analgesics, Opioid; Cancer Pain; Child; Child, Preschool; Electrocar | 2019 |
Association between Use of Methadone, Other Central Nervous System Depressants, and QTc Interval-Prolonging Medications and Risk of Mortality in a Large Cohort of Women Living with or at Risk for Human Immunodeficiency Virus Infection.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Aged; Benzodiazepines; Cause of Death; CD4 Ly | 2019 |
Prolongation of QTc intervals and risk of death among patients with sickle cell disease.
Topics: Adult; Anemia, Sickle Cell; Death, Sudden, Cardiac; Echocardiography; Electrocardiography; Female; F | 2013 |
Trends in reporting methadone-associated cardiac arrhythmia, 1997-2011: an analysis of registry data.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Anti-Retroviral Agents; Heart Arrest; HIV Infections | 2013 |
QTc interval prolongation for patients in methadone maintenance treatment: a five years follow-up study.
Topics: Aged; Electrocardiography; Female; Follow-Up Studies; Humans; Long QT Syndrome; Male; Methadone; Mid | 2013 |
Risk of QTc prolongation in a cohort of opioid-dependent HIV-infected patients on methadone maintenance therapy.
Topics: Adult; CD4 Lymphocyte Count; Cross-Sectional Studies; Female; HIV Infections; Humans; Linear Models; | 2013 |
Editorial commentary: the methadone menace.
Topics: Female; HIV Infections; Humans; Long QT Syndrome; Male; Methadone; Opioid-Related Disorders | 2013 |
Changes of QTc interval after opioid switching to oral methadone.
Topics: Aged; Analgesics, Opioid; Electrocardiography; Female; Humans; Linear Models; Long QT Syndrome; Male | 2013 |
Methadone and torsade de pointes: how can we better understand the association?
Topics: Age Factors; Analgesics, Opioid; Female; Humans; Long QT Syndrome; Male; Methadone; Risk Factors; Se | 2013 |
Comparison of QTc interval prolongation for patients in methadone versus buprenorphine maintenance treatment: a 5-year follow-up.
Topics: Adult; Aged; Buprenorphine; Comorbidity; Dose-Response Relationship, Drug; Electrocardiography; Epid | 2013 |
Drug-induced long QT in adult psychiatric inpatients: the 5-year cross-sectional ECG Screening Outcome in Psychiatry study.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Case-Control Studies; Citalopram; Cross-Sectional Stu | 2013 |
The correlation between prolonged corrected QT interval with the frequency of respiratory arrest, endotracheal intubation, and mortality in acute methadone overdose.
Topics: Adolescent; Adult; Aged; Cross-Sectional Studies; Drug Overdose; Electrocardiography; Female; Humans | 2014 |
KCNH2 polymorphism and methadone dosage interact to enhance QT duration.
Topics: Adult; Aged; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Gene-Environment Inte | 2014 |
KCNH2 polymorphism and methadone dosage interact to enhance QT duration.
Topics: Adult; Aged; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Gene-Environment Inte | 2014 |
KCNH2 polymorphism and methadone dosage interact to enhance QT duration.
Topics: Adult; Aged; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Gene-Environment Inte | 2014 |
KCNH2 polymorphism and methadone dosage interact to enhance QT duration.
Topics: Adult; Aged; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Gene-Environment Inte | 2014 |
Letter to the editor in response to: The correlation between prolonged corrected QT interval with the frequency of respiratory arrest, endotracheal intubation, and mortality in acute methadone overdose.
Topics: Drug Overdose; Female; Humans; Intubation, Intratracheal; Long QT Syndrome; Male; Methadone; Respira | 2014 |
Reply to the letter to the editor in response to: The correlation between prolonged corrected QT interval with the frequency of respiratory arrest, endotracheal intubation, and mortality in acute methadone overdose.
Topics: Drug Overdose; Female; Humans; Intubation, Intratracheal; Long QT Syndrome; Male; Methadone; Respira | 2014 |
The QTc effect of low-dose methadone for chronic pain: a prospective pilot study.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Pain; Cohort Studies; Dose-Response Rela | 2015 |
Methadone Therapy in Underserved Urban Community: QTc Prolongation and Life-Threatening Ventricular Arrhythmias.
Topics: Adult; Aged; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Drug Interactions; Electrocardi | 2015 |
Effects of Hemodialysis on Methadone Pharmacokinetics and QTc.
Topics: Aged; Electrocardiography; Female; Hemodialysis Solutions; Humans; Kidney Failure, Chronic; Long QT | 2015 |
Arrhythmia associated with buprenorphine and methadone reported to the Food and Drug Administration.
Topics: Adult; Arrhythmias, Cardiac; Buprenorphine; Female; Heart Arrest; Humans; Long QT Syndrome; Male; Me | 2015 |
Underestimated and unreported prolonged QTc by automated ECG analysis in patients on methadone: can we rely on computer reading?
Topics: Analgesics, Opioid; Diagnosis, Computer-Assisted; Diagnostic Errors; Electrocardiography; Female; Hu | 2015 |
Drug-induced torsades de pointes in an underserved urban population. Methadone: is there therapeutic equipoise?
Topics: Age Distribution; Causality; Comorbidity; Drug-Related Side Effects and Adverse Reactions; Female; H | 2016 |
The prevalence of QT prolongation in a population of patients with substance use disorders.
Topics: Adult; Age Factors; Aged; Electrocardiography; Female; Hospitals, General; Humans; Long QT Syndrome; | 2017 |
Arrhythmia associated with buprenorphine and methadone reported to the Food and Drug Administration.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Buprenorphine; Dose-Response Relationship, Drug; Humans; L | 2016 |
Reply to Cataldo (2016): Arrhythmia associated with buprenorphine and methadone reported to the Food and Drug Administration.
Topics: Arrhythmias, Cardiac; Buprenorphine; Electrocardiography; Humans; Long QT Syndrome; Methadone; Torsa | 2016 |
Methadone maintenance dose/weight ratio, long QTc, and EKG screening.
Topics: Adult; Body Weight; Brugada Syndrome; Cardiac Conduction System Disease; Dose-Response Relationship, | 2016 |
Ventricular tachycardia and prolonged QT interval presenting as seizure-like activity.
Topics: Adult; Alcoholism; Anti-Arrhythmia Agents; Anticonvulsants; Diuretics; Electrocardiography; Emergenc | 2017 |
Methadone and Corrected QT Prolongation in Pain and Palliative Care Patients: A Case-Control Study.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cancer Pain; Case-Control Studies; Dose-Response | 2017 |
First, remove the offending agent.
Topics: Defibrillators, Implantable; Humans; Long QT Syndrome; Methadone | 2008 |
Prevalence of long QTc interval in methadone maintenance patients.
Topics: Adolescent; Adult; Arrhythmias, Cardiac; Electrocardiography; Female; Heart Rate; Humans; Logistic M | 2009 |
Electrocardiogram characteristics of methadone and buprenorphine maintained subjects.
Topics: Adult; Buprenorphine; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Long QT | 2008 |
Heterogeneous impact of methadone on the QTc interval: what are the practical implications?
Topics: Adolescent; Adult; Analgesics, Opioid; Electrocardiography; Heroin Dependence; Humans; Long QT Syndr | 2008 |
Prevalence and clinical relevance of corrected QT interval prolongation during methadone and buprenorphine treatment: a mortality assessment study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Buprenorphine; Female; Humans; Long QT Syndrome; Male; M | 2009 |
Ventricular arrhythmias in patients treated with methadone for opioid dependence.
Topics: Adult; Cardiac Pacing, Artificial; Dose-Response Relationship, Drug; Drug Administration Schedule; E | 2010 |
Onsite QTc interval screening for patients in methadone maintenance treatment.
Topics: Aged; Dose-Response Relationship, Drug; Electrocardiography; Feasibility Studies; Female; Heart Cond | 2010 |
Does electrocardiography improve methadone safety?
Topics: Cause of Death; Electrocardiography; Humans; Long QT Syndrome; Methadone; Narcotics; Norway; Opioid- | 2010 |
The effect of oral methadone on the QTc interval in advanced cancer patients: a prospective pilot study.
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Heroin Dependence; Humans; Long QT Syndrome; M | 2010 |
Opioid maintenance patients with QTc prolongation: congenital long QT syndrome mutation may be a contributing risk factor.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Electrocardiography; Female; Genetic Testing; Heterozygote | 2010 |
Maternal methadone therapy increases QTc interval in newborn infants.
Topics: Case-Control Studies; Electrocardiography; Female; Humans; Infant, Newborn; Long QT Syndrome; Male; | 2011 |
Cardiovascular-associated disease in an addicted population: an observation study.
Topics: Adult; Buprenorphine; Cardiovascular Diseases; Electrocardiography; Female; Humans; Hypertension; Lo | 2011 |
Methadone maintenance, QTc and torsade de pointes: who needs an electrocardiogram and what is the prevalence of QTc prolongation?
Topics: Adult; Analgesics, Opioid; Cross-Sectional Studies; Electrocardiography; Female; Humans; London; Lon | 2011 |
Left cardiac sympathetic denervation for the treatment of methadone-induced long QT syndrome.
Topics: Defibrillators, Implantable; Device Removal; Electrocardiography; Heart; Heroin Dependence; Humans; | 2011 |
QT or not QT, that is the question: routine electrocardiograms for individuals in methadone maintenance treatment.
Topics: Humans; Long QT Syndrome; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Patien | 2011 |
First, do no harm: QT interval screening in methadone maintenance treatment.
Topics: Humans; Long QT Syndrome; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Patien | 2011 |
QT interval screening in methadone maintenance treatment: report of a SAMHSA expert panel.
Topics: Humans; Long QT Syndrome; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Patien | 2011 |
CSAT's QT interval screening in methadone report: outrageous fortune or sea of troubles?
Topics: Humans; Long QT Syndrome; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Patien | 2011 |
Gender-specific differences in susceptibility to low-dose methadone-associated QTc prolongation in patients with heroin dependence.
Topics: Action Potentials; Adult; Analgesics, Opioid; China; Cross-Sectional Studies; Dose-Response Relation | 2012 |
Individual patient assessment of methadone-induced QT prolongation with digital holter recording.
Topics: Adult; Analgesics, Opioid; Chronic Pain; Dose-Response Relationship, Drug; Electrocardiography, Ambu | 2012 |
Increased incidence of QT interval prolongation in a population receiving lower doses of methadone maintenance therapy.
Topics: Adult; Cross-Sectional Studies; Dose-Response Relationship, Drug; Electrocardiography; Female; Human | 2012 |
Corrected QT interval during treatment with methadone and buprenorphine--relation to doses and serum concentrations.
Topics: Adult; Arrhythmias, Cardiac; Buprenorphine; Electrocardiography; Female; Humans; International Class | 2013 |
Attitudes and practices of pediatric oncologists regarding methadone use in the treatment of cancer-related pain: results of a North American Survey.
Topics: Female; Health Knowledge, Attitudes, Practice; Humans; Long QT Syndrome; Male; Medical Oncology; Met | 2013 |
Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes.
Topics: Adult; Aged; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Hypokalemia; Lon | 2003 |
The impact of methadone induction on cardiac conduction in opiate users.
Topics: Adult; Electrocardiography; Female; Heroin Dependence; Humans; Long QT Syndrome; Male; Methadone | 2003 |
Synthetic opioids and QT prolongation.
Topics: Heroin Dependence; Humans; Long QT Syndrome; Methadone; Narcotics; Syncope | 2003 |
Medications that prolong the QT interval.
Topics: Analgesics, Opioid; Electrocardiography; Humans; Long QT Syndrome; Methadone; Risk | 2003 |
QTc interval prolongation associated with intravenous methadone.
Topics: Cell Line; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Infusions, Intrave | 2003 |
QT prolongation and Torsades de Pointes in patients infected with human immunodeficiency virus and treated with methadone.
Topics: Adult; Analgesics, Opioid; Antiretroviral Therapy, Highly Active; Dose-Response Relationship, Drug; | 2003 |
Methadone and affairs of the heart and of the brain.
Topics: Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Electrocardiography; Humans; Long QT Syndr | 2003 |
Methadone and QT prolongation: a dose-dependent effect?
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Humans; Long QT Syndrome; Methadone; Torsades | 2004 |
Can methadone prolong the QT interval?
Topics: Adult; Analgesics, Opioid; Fatal Outcome; Humans; Long QT Syndrome; Male; Methadone | 2004 |
Methadone and QT prolongation in HIV-infected patients.
Topics: Analgesics, Opioid; HIV Infections; Humans; Long QT Syndrome; Methadone; Torsades de Pointes | 2004 |
QT interval increased after single dose of lofexidine.
Topics: Adult; Clonidine; Female; Humans; Long QT Syndrome; Methadone; Narcotic Antagonists | 2004 |
[Routine ECG in methadone-assisted rehabilitation is wrong prioritization].
Topics: Dose-Response Relationship, Drug; Electrocardiography; Humans; Long QT Syndrome; Methadone; Narcotic | 2004 |
[Long QT and torsade de pointes in a patient with acquired human immunodeficiency virus infection in multitherapy with drugs affecting cytochrome P450].
Topics: Acquired Immunodeficiency Syndrome; Analgesics, Opioid; Antifungal Agents; Antiretroviral Therapy, H | 2004 |
QTc interval prolongation in patients on long-term methadone maintenance therapy.
Topics: Adult; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart Rate; Heroin Dependence; | 2005 |
Torsades de pointes with methadone.
Topics: Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Drug Interactions; Heroin; Humans; Hypokalemia; L | 2005 |
QT prolongation and torsades de pointes among methadone users: reports to the FDA spontaneous reporting system.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Databases, Factual; Female; Humans | 2005 |
[Methadone-induced heart arrhythmia].
Topics: Adult; Electrocardiography; Fatal Outcome; Female; Humans; Long QT Syndrome; Male; Methadone; Middle | 2005 |
QT prolongation and syncope with methadone, doxepin, and a beta-blocker.
Topics: Adrenergic beta-Antagonists; Adult; Anxiety Disorders; Doxepin; Electrocardiography; Humans; Long QT | 2005 |
Re: Methadone in the management of intractable neuropathic noncancer pain.
Topics: Analgesics, Opioid; Electrocardiography; Humans; Long QT Syndrome; Methadone; Neuralgia; Pain, Intra | 2006 |
Drug-induced long QT syndrome in injection drug users receiving methadone: high frequency in hospitalized patients and risk factors.
Topics: Adolescent; Adult; Electrocardiography; Female; Follow-Up Studies; Humans; Long QT Syndrome; Male; M | 2006 |
Syncope of a drug addict - a special case.
Topics: Adult; Female; Heroin Dependence; Humans; Long QT Syndrome; Methadone; Narcotics; Syncope; Torsades | 2006 |
QTc prolongation: methadone's efficacy-safety paradox.
Topics: Analgesics, Opioid; Heroin Dependence; Humans; Long QT Syndrome; Methadone; Randomized Controlled Tr | 2006 |
A twist on torsade: a prolonged QT interval on methadone.
Topics: Female; Humans; Long QT Syndrome; Methadone; Middle Aged; Torsades de Pointes | 2006 |
Cocaine and methadone: parallel effects on the QTc interval.
Topics: Cocaine; Dopamine Uptake Inhibitors; Heart Rate; Humans; Long QT Syndrome; Methadone; Potassium Chan | 2006 |
QTc prolongation in human immunodeficiency virus-infected persons.
Topics: Adolescent; Adult; Aged; Anti-HIV Agents; Electrocardiography; Female; HIV Infections; Humans; Long | 2006 |
Methadone-induced long QT syndrome vs methadone-induced torsades de pointes.
Topics: Adolescent; Adult; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Methadone; Middle Ag | 2006 |
QTc prolongation among hospitalized patients receiving methadone.
Topics: Adolescent; Adult; Electrocardiography; Female; Follow-Up Studies; Humans; Inpatients; Long QT Syndr | 2006 |
Methadone and the QT interval: relations to the serum concentrations of methadone and its enantiomers (R)-methadone and (S)-methadone.
Topics: Adult; Drug Monitoring; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Methadone; Narc | 2006 |
[Heart arrhythmia and sudden death during methadone therapy].
Topics: Death, Sudden; Death, Sudden, Cardiac; Humans; Long QT Syndrome; Methadone; Narcotics; Opioid-Relate | 2007 |
Corrected-QT intervals as related to methadone dose and serum level in methadone maintenance treatment (MMT) patients: a cross-sectional study.
Topics: Adolescent; Adult; Cross-Sectional Studies; Electrocardiography; Female; Follow-Up Studies; Heroin D | 2007 |
[Methadone treatment and heart arrhythmia].
Topics: Death, Sudden; Death, Sudden, Cardiac; Humans; Long QT Syndrome; Methadone; Narcotics | 2007 |
Stereoselective block of hERG channel by (S)-methadone and QT interval prolongation in CYP2B6 slow metabolizers.
Topics: Adult; Alleles; Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B6; DNA, Com | 2007 |
Syncope and QT prolongation among patients treated with methadone for heroin dependence in the city of Copenhagen.
Topics: Adult; Buprenorphine; Cross-Sectional Studies; Dose-Response Relationship, Drug; Electrocardiography | 2007 |
Maternal methadone may cause arrhythmias in neonates.
Topics: Electrocardiography; Female; Humans; Infant, Newborn; Long QT Syndrome; Methadone; Narcotics; Pregna | 2007 |
QTc prolongation and torsades de pointes associated with methadone therapy.
Topics: Electrocardiography; Female; Humans; Long QT Syndrome; Methadone; Middle Aged; Narcotics; Opioid-Rel | 2007 |
[Methadone and arrhythmia--final comment].
Topics: Humans; Long QT Syndrome; Methadone; Narcotics; Opioid-Related Disorders; Risk Factors | 2007 |
[An abnormal electrocardiogram in a drug addict patient].
Topics: Bradycardia; Diagnosis, Differential; Electrocardiography; Humans; Long QT Syndrome; Male; Methadone | 2007 |
Methadone-associated QT prolongation and torsades de pointes.
Topics: Analgesics, Opioid; Humans; Long QT Syndrome; Methadone; Opioid-Related Disorders; Torsades de Point | 2007 |
Methadone-associated QT prolongation and torsades de pointes. Dubrey and Groscott-Mason's patient was underttreated for her atrial fibrillation.
Topics: Analgesics, Opioid; Atrial Fibrillation; Humans; Long QT Syndrome; Methadone; Opioid-Related Disorde | 2007 |
The successful use of parenteral methadone in a patient with a prolonged QTc interval.
Topics: Analgesics, Opioid; Carcinoma, Renal Cell; Humans; Infusions, Parenteral; Kidney Neoplasms; Long QT | 2007 |
Physician awareness of the cardiac effects of methadone: results of a national survey.
Topics: Arrhythmias, Cardiac; Awareness; Heroin Dependence; Humans; Long QT Syndrome; Methadone; Narcotics; | 2007 |
Case files of the Drexel University Medical Toxicology Fellowship: methadone-induced QTc prolongation.
Topics: Adult; Drug Overdose; Electrocardiography; Emergency Medical Services; Humans; Long QT Syndrome; Mal | 2007 |
Role of implantable cardioverter-defibrillators in patients with methadone-induced long QT syndrome.
Topics: Cohort Studies; Defibrillators, Implantable; Electrocardiography; Female; Humans; Long QT Syndrome; | 2008 |