methadone has been researched along with Inflammation in 18 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In a double-blind, randomly stratified clinical trial investigating whether add-on dextromethorphan (60-120 mg/day) attenuated inflammation and the combined use of opioids in heroin-dependent patients undergoing methadone maintenance treatment, we evaluated whether inflammation is related to the progression of opioid dependence." | 9.16 | Dextromethorphan attenuated inflammation and combined opioid use in humans undergoing methadone maintenance treatment. ( Chang, YH; Chen, PS; Chen, SH; Chen, SL; Chu, CH; Hong, JS; Lee, IH; Lee, SY; Lu, RB; Tao, PL; Yang, YK; Yeh, TL, 2012) |
| " Thus, the present study aimed to investigate whether the damaging effects of morphine dependence were reversed by the spontaneous morphine withdrawal or incubation with methadone and/or naloxone in Sertoli (TM4) cells using an in- vitro cell model of morphine dependence." | 8.02 | Morphine dependence and withdrawal-induced changes in mouse Sertoli cell (TM4) line: Evaluation of apoptotic, inflammatory and oxidative stress biomarkers. ( Miladi-Gorji, H; Pourhassanali, N; Zarbakhsh, S, 2021) |
| " In a double-blind, randomly stratified clinical trial investigating whether add-on dextromethorphan (60-120 mg/day) attenuated inflammation and the combined use of opioids in heroin-dependent patients undergoing methadone maintenance treatment, we evaluated whether inflammation is related to the progression of opioid dependence." | 5.16 | Dextromethorphan attenuated inflammation and combined opioid use in humans undergoing methadone maintenance treatment. ( Chang, YH; Chen, PS; Chen, SH; Chen, SL; Chu, CH; Hong, JS; Lee, IH; Lee, SY; Lu, RB; Tao, PL; Yang, YK; Yeh, TL, 2012) |
| " Thus, the present study aimed to investigate whether the damaging effects of morphine dependence were reversed by the spontaneous morphine withdrawal or incubation with methadone and/or naloxone in Sertoli (TM4) cells using an in- vitro cell model of morphine dependence." | 4.02 | Morphine dependence and withdrawal-induced changes in mouse Sertoli cell (TM4) line: Evaluation of apoptotic, inflammatory and oxidative stress biomarkers. ( Miladi-Gorji, H; Pourhassanali, N; Zarbakhsh, S, 2021) |
| "Here, we report a patient who developed acute bilateral hearing loss, ataxia and paraparesis subsequently to intravenous methadone-abuse." | 4.02 | Intravenous methadone causes acute toxic and delayed inflammatory encephalopathy with persistent neurocognitive impairments. ( Haessner, S; Johnen, A; Landmeyer, NC; Meyer Zu Hörste, G; Pawlitzki, M; Repple, J; Schulte-Mecklenbeck, A; Wiendl, H, 2021) |
| " In this study, we aimed to investigate the effects of two opioids (morphine and methadone) against inflammation in lipopolysaccharide (LPS)-stimulated synoviocytes by analyzing microsomal prostaglandin E synthase-1 (mPGES-1) and prostaglandin-endoperoxide synthase 2 (PTGS2) expression." | 3.91 | Morphine, but not methadone, inhibits microsomal prostaglandin E synthase-1 and prostaglandin-endoperoxide synthase 2 in lipopolysaccharide-stimulated horse synoviocytes. ( Ambrósio, CE; Carregaro, AB; Cordeiro, YG; Fukumasu, H; Melo, CF; Roballo, KC; Schwarzbach, SV; Xavier, PLP, 2019) |
| "Antinociceptive effect of narcotic analgesics, fentanyl, oxycodone and methadone in inflammatory pain state was described in the von Frey filament test using the complete Freund's adjuvant (CFA)-induced mouse inflammatory pain model." | 3.80 | Differential alternation of the antinociceptive effect of narcotic analgesics on the inflammatory pain state. ( Aoki, Y; Mizoguchi, H; Sakurada, S; Sakurada, T; Watanabe, C, 2014) |
| " The effect of experimental inflammation on methadone analgesia was evaluated in rats, by the tail-flick test, after single intravenous (0." | 3.69 | Altered methadone analgesia due to changes in plasma protein binding: role of the route of administration. ( Calvo, R; Garrido, MJ; Gómez, E; Martínez-Jordá, R; Suárez, E, 1995) |
| "Medication-assisted treatment for opioid use disorder with methadone or buprenorphine may ameliorate some of this risk; however, there is presently limited research in humans, including in non-HIV populations, describing changes in immune activation on these treatments which is of paramount importance for those with HIV infection." | 2.61 | The Opioid Epidemic: Impact on Inflammation and Cardiovascular Disease Risk in HIV. ( Hileman, CO; McComsey, GA, 2019) |
| "Methadone (MET)-based treatment is currently one of the best known approaches in the treatment of opioid dependence." | 1.48 | Histopathological study of liver tissue due to methadone consumption and its effect on liver enzymes and inflammatory indices in rat. ( Ahmadi, MRH; Amraei, M; Azizi, M; Daemi, A; Mohamadpour, M; Omidi, M; Shirzadpour, E, 2018) |
| " Plasma TNF-α and IL-6 levels were significantly correlated with the dairy methadone dosage administered, and the IL-1β level was significantly correlated with the duration of methadone maintenance treatment." | 1.42 | Inflammatory response in heroin addicts undergoing methadone maintenance treatment. ( Chan, YY; Chang, JL; Lin, JC; Lin, JG; Lo, WY; Yang, SN, 2015) |
| "The new definition of the term sudden infant death syndrome (SIDS) and the criteria introduced in San Diego for the subclassification of cases have been used to re-classify the first 100 consecutive cases of sudden and unexpected infant deaths that were registered with the German SIDS study (GeSID)." | 1.33 | The San Diego definition of SIDS: practical application and comparison with the GeSID classification. ( Bajanowski, T; Brinkmann, B; Vennemann, M, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.11) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 10 (55.56) | 24.3611 |
| 2020's | 4 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Pourhassanali, N | 1 |
| Zarbakhsh, S | 1 |
| Miladi-Gorji, H | 1 |
| Azzoni, L | 1 |
| Giron, LB | 1 |
| Vadrevu, S | 1 |
| Zhao, L | 2 |
| Lalley-Chareczko, L | 1 |
| Hiserodt, E | 1 |
| Fair, M | 1 |
| Lynn, K | 1 |
| Trooskin, S | 1 |
| Mounzer, K | 1 |
| Abdel-Mohsen, M | 1 |
| Montaner, LJ | 1 |
| Hileman, CO | 1 |
| McComsey, GA | 1 |
| Lu, RB | 2 |
| Wang, TY | 1 |
| Lee, SY | 2 |
| Chen, SL | 2 |
| Chang, YH | 2 |
| See Chen, P | 1 |
| Lin, SH | 1 |
| Chu, CH | 2 |
| Huang, SY | 1 |
| Tzeng, NS | 1 |
| Lee, IH | 2 |
| Chin Chen, K | 1 |
| Kuang Yang, Y | 1 |
| Chen, P | 1 |
| Chen, SH | 2 |
| Hong, JS | 2 |
| Halim, AA | 1 |
| Alsayed, B | 1 |
| Embarak, S | 1 |
| Yaseen, T | 1 |
| Dabbous, S | 1 |
| Fontaine, O | 1 |
| Dueluzeau, R | 1 |
| Raibaud, P | 1 |
| Chabanet, C | 1 |
| Popoff, MR | 1 |
| Badoual, J | 1 |
| Gabilan, JC | 1 |
| Andremont, A | 1 |
| Gómez, L | 1 |
| Andrés, S | 1 |
| Sánchez, J | 1 |
| Alonso, JM | 1 |
| Rey, J | 1 |
| López, F | 1 |
| Jiménez, A | 1 |
| Yan, Z | 1 |
| Zhou, L | 1 |
| Zhao, Y | 3 |
| Wang, J | 6 |
| Huang, L | 2 |
| Hu, K | 1 |
| Liu, H | 4 |
| Wang, H | 3 |
| Guo, Z | 1 |
| Song, Y | 1 |
| Huang, H | 4 |
| Yang, R | 1 |
| Owen, TW | 1 |
| Al-Kaysi, RO | 1 |
| Bardeen, CJ | 1 |
| Cheng, Q | 1 |
| Wu, S | 1 |
| Cheng, T | 1 |
| Zhou, X | 1 |
| Wang, B | 4 |
| Zhang, Q | 4 |
| Wu, X | 2 |
| Yao, Y | 3 |
| Ochiai, T | 1 |
| Ishiguro, H | 2 |
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| Kubota, Y | 2 |
| Hara, M | 1 |
| Sunada, K | 1 |
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| Kajioka, J | 1 |
| Fujishima, A | 1 |
| Jiao, J | 3 |
| Gai, QY | 3 |
| Wang, W | 2 |
| Zang, YP | 2 |
| Niu, LL | 2 |
| Fu, YJ | 3 |
| Wang, X | 4 |
| Yao, LP | 1 |
| Qin, QP | 1 |
| Wang, ZY | 1 |
| Liu, J | 4 |
| Aleksic Sabo, V | 1 |
| Knezevic, P | 1 |
| Borges-Argáez, R | 1 |
| Chan-Balan, R | 1 |
| Cetina-Montejo, L | 1 |
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| Wilson, BK | 1 |
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| Achberger, AM | 1 |
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| Schwehr, K | 1 |
| Santschi, PH | 1 |
| Sylvan, JB | 1 |
| Quigg, A | 1 |
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| Gao, S | 1 |
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| Gilson, E | 1 |
| Ye, J | 1 |
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| Zhang, Y | 7 |
| Hu, Z | 1 |
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| Shao, H | 1 |
| Gestwicki, JE | 1 |
| Tsai, S | 1 |
| Park, JI | 1 |
| Wang, Y | 7 |
| Zhao, R | 1 |
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| Guo, G | 1 |
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| Barrett, HE | 1 |
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| van Gaalen, K | 1 |
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| Shirzadpour, E | 1 |
| Schwarzbach, SV | 1 |
| Melo, CF | 1 |
| Xavier, PLP | 1 |
| Roballo, KC | 1 |
| Cordeiro, YG | 1 |
| Ambrósio, CE | 1 |
| Fukumasu, H | 1 |
| Carregaro, AB | 1 |
| Aoki, Y | 1 |
| Mizoguchi, H | 1 |
| Watanabe, C | 1 |
| Sakurada, T | 1 |
| Sakurada, S | 1 |
| Chan, YY | 1 |
| Yang, SN | 1 |
| Lin, JC | 1 |
| Chang, JL | 1 |
| Lo, WY | 1 |
| Hutchinson, MR | 1 |
| Lewis, SS | 1 |
| Coats, BD | 1 |
| Rezvani, N | 1 |
| Wieseler, JL | 1 |
| Somogyi, AA | 1 |
| Yin, H | 1 |
| Maier, SF | 1 |
| Rice, KC | 1 |
| Watkins, LR | 1 |
| Tao, PL | 1 |
| Chen, PS | 1 |
| Yeh, TL | 1 |
| Yang, YK | 1 |
| Bajanowski, T | 1 |
| Brinkmann, B | 1 |
| Vennemann, M | 1 |
| Gómez, E | 1 |
| Martínez-Jordá, R | 1 |
| Suárez, E | 1 |
| Garrido, MJ | 1 |
| Calvo, R | 1 |
| Rothbard, MJ | 1 |
| Gregory, T | 1 |
| Salerno, LJ | 1 |
| Lamb, D | 1 |
| Roberts, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pomegranate Juice Consumption by Patients Under Medication for Addiction Treatment as a Regulator of Craving and Blood Redox Status: The Study Protocol of a Randomized Control Trial (the NUTRIDOPE Study)[NCT05861544] | 58 participants (Anticipated) | Interventional | 2023-03-23 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for methadone and Inflammation
| Article | Year |
|---|---|
The Opioid Epidemic: Impact on Inflammation and Cardiovascular Disease Risk in HIV.
Topics: Analgesics, Opioid; Buprenorphine; Cardiovascular Diseases; HIV Infections; Humans; Inflammation; Me | 2019 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Periodontal complications of prescription and recreational drugs.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Calcium Channel | 2018 |
2 trials available for methadone and Inflammation
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Dextromethorphan attenuated inflammation and combined opioid use in humans undergoing methadone maintenance treatment.
Topics: Adult; Amphetamine; Amphetamine-Related Disorders; Analgesics, Opioid; Central Nervous System Stimul | 2012 |
14 other studies available for methadone and Inflammation
| Article | Year |
|---|---|
Morphine dependence and withdrawal-induced changes in mouse Sertoli cell (TM4) line: Evaluation of apoptotic, inflammatory and oxidative stress biomarkers.
Topics: Analgesics, Opioid; Animals; Apoptosis; Biomarkers; Cell Line; Cyclic AMP; Glial Cell Line-Derived N | 2021 |
Methadone use is associated with increased levels of sCD14, immune activation, and inflammation during suppressed HIV infection.
Topics: Analgesics, Opioid; Cross-Sectional Studies; Cytokines; HIV Infections; Humans; Immunoglobulin G; In | 2022 |
Correlation between interleukin-6 levels and methadone maintenance therapy outcomes.
Topics: Adolescent; Adult; Aged; Biomarkers; Brain-Derived Neurotrophic Factor; C-Reactive Protein; Female; | 2019 |
Suppressor capacity of copper nanoparticles biosynthesized using Crocus sativus L. leaf aqueous extract on methadone-induced cell death in adrenal phaeochromocytoma (PC12) cell line.
Topics: Animals; Antioxidants; Cell Survival; Copper; Crocus; Cytokines; Drug Screening Assays, Antitumor; I | 2020 |
Intravenous methadone causes acute toxic and delayed inflammatory encephalopathy with persistent neurocognitive impairments.
Topics: Administration, Intravenous; Analgesics, Opioid; Ataxia; Brain; Brain Diseases; Brain Edema; Cogniti | 2021 |
Histopathological study of liver tissue due to methadone consumption and its effect on liver enzymes and inflammatory indices in rat.
Topics: Alanine Transaminase; Alkaline Phosphatase; Analgesics, Opioid; Animals; Aspartate Aminotransferases | 2018 |
Morphine, but not methadone, inhibits microsomal prostaglandin E synthase-1 and prostaglandin-endoperoxide synthase 2 in lipopolysaccharide-stimulated horse synoviocytes.
Topics: Analgesics, Opioid; Animals; Cells, Cultured; Cyclooxygenase 2; Gene Expression Regulation, Enzymolo | 2019 |
Differential alternation of the antinociceptive effect of narcotic analgesics on the inflammatory pain state.
Topics: Animals; Fentanyl; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Methadone; Mice; Narcotics; | 2014 |
Inflammatory response in heroin addicts undergoing methadone maintenance treatment.
Topics: Adult; Case-Control Studies; Female; Heroin; Heroin Dependence; Humans; Inflammation; Interleukin-10 | 2015 |
Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences.
Topics: Analgesics, Opioid; Animals; Gliosis; Hyperalgesia; Immunity, Innate; Inflammation; Inflammation Med | 2010 |
The San Diego definition of SIDS: practical application and comparison with the GeSID classification.
Topics: Age Distribution; Bedding and Linens; California; Child Abuse; Child Development; Forensic Medicine; | 2006 |
Altered methadone analgesia due to changes in plasma protein binding: role of the route of administration.
Topics: Animals; Carrier Proteins; Drug Administration Routes; Inflammation; Injections, Intravenous; Inject | 1995 |
Intrapartum gonococcal amnionitis.
Topics: Acute Disease; Adult; Amnion; Apgar Score; Female; Gonorrhea; Heroin Dependence; Humans; Infant, New | 1975 |
Starch and talc emboli in drug addicts' lungs.
Topics: Acetaminophen; Adult; Alcohols; Amobarbital; Animals; Barbiturates; Female; Foreign-Body Reaction; H | 1972 |