Page last updated: 2024-10-30

methadone and Infant, Small for Gestational Age

methadone has been researched along with Infant, Small for Gestational Age in 12 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Infant, Small for Gestational Age: An infant having a birth weight lower than expected for its gestational age.

Research Excerpts

ExcerptRelevanceReference
" In early pregnancy, 10,704 pregnant persons were exposed to buprenorphine and 4387 to methadone."8.12Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy. ( Bateman, BT; Connery, HS; Davis, JM; Gray, KJ; Hernández-Díaz, S; Huybrechts, KF; Jones, HE; Lester, B; Mogun, H; Straub, L; Suarez, EA; Terplan, M, 2022)
"To examine the association between retention in methadone treatment during pregnancy and key neonatal outcomes."7.74Methadone in pregnancy: treatment retention and neonatal outcomes. ( Burns, L; Lim, K; Mattick, RP; Wallace, C, 2007)
"Weight loss was less in small for gestational age compared to appropriately grown infants (p<0."5.38Postnatal weight loss in substitute methadone-exposed infants: implications for the management of breast feeding. ( Campbell, N; Dryden, C; Mactier, H; Young, D, 2012)
" In early pregnancy, 10,704 pregnant persons were exposed to buprenorphine and 4387 to methadone."4.12Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy. ( Bateman, BT; Connery, HS; Davis, JM; Gray, KJ; Hernández-Díaz, S; Huybrechts, KF; Jones, HE; Lester, B; Mogun, H; Straub, L; Suarez, EA; Terplan, M, 2022)
"Two national cohorts of women receiving opioid maintenance treatment during pregnancy showed small but not statistically significant differences in neonatal outcomes in favour of buprenorphine compared with methadone."3.88Neonatal outcomes after fetal exposure to methadone and buprenorphine: national registry studies from the Czech Republic and Norway. ( Engeland, A; Gabrhelík, R; Handal, M; Lund, IO; Mravčík, V; Nechanská, B; Skurtveit, S, 2018)
"  Methadone use in pregnancy has been associated with adverse perinatal outcomes and neonatal abstinence syndrome (NAS)."3.78Methadone and perinatal outcomes: a prospective cohort study. ( Carmody, D; Clarke, T; Cleary, BJ; Eogan, M; Fahey, T; Gallagher, PJ; Gleeson, J; McDermott, C; Murphy, DJ; O'Connell, MP; O'Sullivan, A; White, MJ, 2012)
"To examine the association between retention in methadone treatment during pregnancy and key neonatal outcomes."3.74Methadone in pregnancy: treatment retention and neonatal outcomes. ( Burns, L; Lim, K; Mattick, RP; Wallace, C, 2007)
" Mean birthweight of infants born to mothers abusing heroin during the pregnancy was 2,490 gm, an effect primarily of intrauterine growth retardation."3.65Differential effects of maternal heroin and methadone use on birthweight. ( Albin, S; Berle, B; Eidelman, AI; Gartner, LM; Kandall, SR; Lowinson, J, 1976)
"Weight loss was less in small for gestational age compared to appropriately grown infants (p<0."1.38Postnatal weight loss in substitute methadone-exposed infants: implications for the management of breast feeding. ( Campbell, N; Dryden, C; Mactier, H; Young, D, 2012)
"85% of the newborns had withdrawal symptoms and 12% had convulsions the severity of which was not correlated with the type of drug abuse."1.27Investigation of 89 children born by drug-dependent mothers. I. Neonatal course. ( Andersen, GE; Buckley, W; Friis-Hansen, B; Olofsson, M, 1983)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19906 (50.00)18.7374
1990's1 (8.33)18.2507
2000's1 (8.33)29.6817
2010's3 (25.00)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Suarez, EA3
Huybrechts, KF3
Straub, L3
Hernández-Díaz, S3
Jones, HE3
Connery, HS3
Davis, JM3
Gray, KJ3
Lester, B3
Terplan, M3
Mogun, H3
Bateman, BT3
Nechanská, B1
Mravčík, V1
Skurtveit, S1
Lund, IO1
Gabrhelík, R1
Engeland, A1
Handal, M1
Dryden, C1
Young, D1
Campbell, N1
Mactier, H1
Cleary, BJ1
Eogan, M1
O'Connell, MP1
Fahey, T1
Gallagher, PJ1
Clarke, T1
White, MJ1
McDermott, C1
O'Sullivan, A1
Carmody, D1
Gleeson, J1
Murphy, DJ1
Burns, L1
Mattick, RP1
Lim, K1
Wallace, C1
Olofsson, M1
Buckley, W1
Andersen, GE1
Friis-Hansen, B1
Hogerzeil, HV1
Soepatmi, S1
Kreijenbroek, M1
Treffers, PE1
Dar, H1
Schmidt, R1
Nitowsky, HM1
Oleske, JM1
Kandall, SR1
Albin, S1
Lowinson, J1
Berle, B1
Eidelman, AI1
Gartner, LM1
Lam, SK1
To, WK1
Duthie, SJ1
Ma, HK1
Ellwood, DA1
Sutherland, P1
Kent, C1
O'Connor, M1

Other Studies

12 other studies available for methadone and Infant, Small for Gestational Age

ArticleYear
Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.
    The New England journal of medicine, 2022, 12-01, Volume: 387, Issue:22

    Topics: Buprenorphine; Cesarean Section; Cohort Studies; Female; Humans; Infant; Infant, Low Birth Weight; I

2022
Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.
    The New England journal of medicine, 2022, 12-01, Volume: 387, Issue:22

    Topics: Buprenorphine; Cesarean Section; Cohort Studies; Female; Humans; Infant; Infant, Low Birth Weight; I

2022
Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.
    The New England journal of medicine, 2022, 12-01, Volume: 387, Issue:22

    Topics: Buprenorphine; Cesarean Section; Cohort Studies; Female; Humans; Infant; Infant, Low Birth Weight; I

2022
Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.
    The New England journal of medicine, 2022, 12-01, Volume: 387, Issue:22

    Topics: Buprenorphine; Cesarean Section; Cohort Studies; Female; Humans; Infant; Infant, Low Birth Weight; I

2022
Neonatal outcomes after fetal exposure to methadone and buprenorphine: national registry studies from the Czech Republic and Norway.
    Addiction (Abingdon, England), 2018, Volume: 113, Issue:7

    Topics: Abortion, Spontaneous; Adult; Analgesics, Opioid; Apgar Score; Buprenorphine; Czech Republic; Female

2018
Postnatal weight loss in substitute methadone-exposed infants: implications for the management of breast feeding.
    Archives of disease in childhood. Fetal and neonatal edition, 2012, Volume: 97, Issue:3

    Topics: Adolescent; Adult; Birth Weight; Bottle Feeding; Breast Feeding; Female; Gestational Age; Humans; In

2012
Methadone and perinatal outcomes: a prospective cohort study.
    Addiction (Abingdon, England), 2012, Volume: 107, Issue:8

    Topics: Adult; Benzodiazepines; Dose-Response Relationship, Drug; Female; Heroin Dependence; Humans; Infant,

2012
Methadone in pregnancy: treatment retention and neonatal outcomes.
    Addiction (Abingdon, England), 2007, Volume: 102, Issue:2

    Topics: Adult; Female; Humans; Infant, Newborn; Infant, Premature; Infant, Small for Gestational Age; Methad

2007
Investigation of 89 children born by drug-dependent mothers. I. Neonatal course.
    Acta paediatrica Scandinavica, 1983, Volume: 72, Issue:3

    Topics: Adult; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Infant, Small

1983
[Pregnancy in heroin addiction; an 11-year survey at the Wilhelmina Gasthuis in Amsterdam].
    Nederlands tijdschrift voor geneeskunde, 1982, Feb-20, Volume: 126, Issue:8

    Topics: Female; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn; Infant, Premature; Infant, Sma

1982
Palmar crease variants and their clinical significance: a study of newborns at risk.
    Pediatric research, 1977, Volume: 11, Issue:2

    Topics: Adult; Age Factors; Child; Child, Preschool; Dermatoglyphics; Down Syndrome; Female; Fetus; Hand; Hu

1977
Experiences with 118 infants born to narcotic-using mothers. Does a lowered serum-ionized calcium level contribute to the symptoms of withdrawal?
    Clinical pediatrics, 1977, Volume: 16, Issue:5

    Topics: Calcium; Female; Follow-Up Studies; Heroin Dependence; Humans; Infant, Low Birth Weight; Infant, New

1977
Differential effects of maternal heroin and methadone use on birthweight.
    Pediatrics, 1976, Volume: 58, Issue:5

    Topics: Adult; Birth Weight; Dose-Response Relationship, Drug; Ethnicity; Female; Gestational Age; Heroin; H

1976
Narcotic addiction in pregnancy with adverse maternal and perinatal outcome.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1992, Volume: 32, Issue:3

    Topics: Adult; Female; Fetal Growth Retardation; Heroin Dependence; Hong Kong; Humans; Infant, Low Birth Wei

1992
Maternal narcotic addiction: pregnancy outcome in patients managed by a specialized drug-dependency antenatal clinic.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1987, Volume: 27, Issue:2

    Topics: Adolescent; Adult; Female; Fetal Death; Health Facilities; Heroin Dependence; Humans; Infant, Newbor

1987