Page last updated: 2024-10-30

methadone and Infant, Premature, Diseases

methadone has been researched along with Infant, Premature, Diseases in 5 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Infant, Premature, Diseases: Diseases that occur in PREMATURE INFANTS.

Research Excerpts

Excerpt	Relevance	Reference
"They were also offered residential treatment before pregnancy and after the child was born."	1.35	Patterns in sleep-wakefulness in three-month old infants exposed to methadone or buprenorphine. ( Bakstad, B; Martinsen, H; Røislien, J; Sarfi, M; Waal, H, 2009)

Research

Studies (5)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (20.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	2 (40.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Hall, ES	1
Wexelblatt, SL	1
Crowley, M	1
Grow, JL	1
Jasin, LR	1
Klebanoff, MA	1
McClead, RE	1
Meinzen-Derr, J	1
Mohan, VK	1
Stein, H	1
Walsh, MC	1
Sarfi, M	1
Martinsen, H	1
Bakstad, B	1
Røislien, J	1
Waal, H	1
Backes, CH	1
Backes, CR	1
Gardner, D	1
Nankervis, CA	1
Giannone, PJ	1
Cordero, L	1
Connaughton, JF	1
Finnegan, LP	1
Schut, J	1
Emich, JP	1
Thornton, L	1
Clune, M	1
Maguire, R	1
Griffin, E	1
O'Connor, J	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Morphine Versus Methadone for Opiate Exposed Infants With Neonatal Abstinence Syndrome[NCT02851303]			Phase 4	61 participants (Actual)	Interventional	2016-10-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Breastfeeding Initiation and Continuation at Hospital Discharge

Assessed through chart review of discharge summary documentation of method of infant feeding at time of discharge (NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days

Intervention	Participants (Count of Participants)
Morphine	5
Methadone	5

Length of Hospital Stay

Number of days in hospital after birth (NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days

Intervention	days (Mean)
Morphine	17.9
Methadone	16.1

Length of Treatment

(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days

Intervention	days (Mean)
Morphine	14.7
Methadone	12.8

Need for Additional Agent to Treat Withdrawal, Determined by Chart Review of Medication Administration Record of Administered Medications for Withdrawal Treatment (Example: Clonidine or Phenobarbital)

clonidine (NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days

Intervention	Participants (Count of Participants)
Morphine	1
Methadone	0

Need for Feeding Assistance, Determined by Chart Review of Discharge Summary, Specifically Evaluating for Need for Nasogastric Tube Placement or Peripheral Parenteral Nutrition.

(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days

Intervention	Participants (Count of Participants)
Morphine	11
Methadone	6

Need for NICU Transfer, as Determined by Chart Review of Discharge Summary.

(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days

Intervention	Participants (Count of Participants)
Morphine	0
Methadone	3

Total Morphine Equivalent Dose Received

(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days

Intervention	morphine equivalents mg (Mean)
Morphine	9.86
Methadone	33.0

Other Studies

5 other studies available for methadone and Infant, Premature, Diseases

Article	Year
A multicenter cohort study of treatments and hospital outcomes in neonatal abstinence syndrome. Pediatrics, 2014, Volume: 134, Issue:2 Topics: Adult; Clinical Protocols; Female; Humans; Hypnotics and Sedatives; Infant, Newborn; Infant, Prematu	2014
Patterns in sleep-wakefulness in three-month old infants exposed to methadone or buprenorphine. Early human development, 2009, Volume: 85, Issue:12 Topics: Adult; Buprenorphine; Chronobiology Disorders; Female; Humans; Infant; Infant Behavior; Infant, Newb	2009
Neonatal abstinence syndrome: transitioning methadone-treated infants from an inpatient to an outpatient setting. Journal of perinatology : official journal of the California Perinatal Association, 2012, Volume: 32, Issue:6 Topics: Ambulatory Care; Female; Hospitalization; Humans; Infant, Newborn; Infant, Premature, Diseases; Leng	2012
Current concepts in the management of the pregnant opiate addict. Addictive diseases, 1975, Volume: 2, Issue:1-2 Topics: Administration, Oral; Anesthesia, Conduction; Anesthesia, Obstetrical; Birth Weight; Counseling; Fem	1975
Narcotic addiction: the expectant mother and her baby. Irish medical journal, 1990, Volume: 83, Issue:4 Topics: Adolescent; Adult; Diseases in Twins; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Pr	1990