Page last updated: 2024-10-30

methadone and Infant, Newborn, Diseases

methadone has been researched along with Infant, Newborn, Diseases in 118 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Infant, Newborn, Diseases: Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts.

Research Excerpts

ExcerptRelevanceReference
"To assess the outcomes of infants born to mothers receiving methadone for the management of pain in pregnancy."7.72Outcomes of infants born to mothers receiving methadone for pain management in pregnancy. ( Kuschel, C; Sharpe, C, 2004)
"The course of pregnancy and delivery in 28 women under closely supervised methadone maintenance (group 1) was compared with that of 57 women using heroin or methadone under less controlled circumstances (group 2) and with that of 30 women free of mood-altering medications (group 3)."7.65Narcotic dependency in pregnancy. Methadone maintenance compared to use of street drugs. ( Adamsons, K; Stimmel, B, 1976)
"Methadone use was associated with 21."5.91Opioid and Methadone Use for Infants With Surgically Treated Necrotizing Enterocolitis. ( Keane, OA; Kelley-Quon, LI; Kim, E; Kim, ES; Lakshmanan, A; Mahdi, EM; Ourshalimian, S; Song, AY; Zamora, AK, 2023)
" Opioid exposure during pregnancy included 16 202 pregnancies exposed to codeine, 4540 to oxycodone, 1244 to tramadol, 260 to methadone (dispensed for pain), 90 to hydromorphone, and 63 to morphine compared with 25 710 exposed to hydrocodone."4.12Characteristics of Prescription Opioid Analgesics in Pregnancy and Risk of Neonatal Opioid Withdrawal Syndrome in Newborns. ( Bateman, BT; Esposito, DB; Hernández-Díaz, S; Huybrechts, KF; Mogun, H; Straub, L; Werler, MM, 2022)
"To assess the outcomes of infants born to mothers receiving methadone for the management of pain in pregnancy."3.72Outcomes of infants born to mothers receiving methadone for pain management in pregnancy. ( Kuschel, C; Sharpe, C, 2004)
" The majority of women in the CDU clinic were treated for narcotic addiction with methadone (90%) but most continued to use heroin during pregnancy (68%)."3.70The drug epidemic: effects on newborn infants and health resource consumption at a tertiary perinatal centre. ( Davis, PG; Henschke, PN; Kelly, JJ, 2000)
" Both of the mothers were on methadone maintenance for narcotic dependency prior to the diagnosis of pregnancy."3.68Diazepam abuse in pregnant women on methadone maintenance. Implications for the neonate. ( Hinderliter, SA; Sutton, LR, 1990)
"This study compares the first year's health, neurodevelopmental status, and environment of infants of drug-dependent mothers attending methadone programs during pregnancy with those of drug-dependent mothers not enrolled in treatment programs (untreated)."3.66Follow-up of methadone-treated and untreated narcotic-dependent women and their infants: health, developmental, and social implications. ( Desmond, MM; Wait, RB; Wilson, GS, 1981)
"The effects of maternal use of methadone during pregnancy on tests of thyroid function were studied in 14 women and their offspring."3.66Effects of methadone on thyroid function in mother, fetus, and newborn. ( Chandavasu, O; Dube, SK; Evans, HE; Glass, L; Jhaveri, RC; Khan, F; Rosenfeld, W; Salazar, JD, 1980)
"A review of research concerning the effects of methadone on infants born to mothers who received the drug during their pregnancy is presented."3.66The congenitally methadone-addicted infant. ( Fleming, JW; Rosser, P, 1979)
" Heroin abuse declined while methadone usage increased during those years."3.65The narcotic-dependent mother: fetal and neonatal consequences. ( Albin, S; Eidelman, A; Gartner, LM; Kandall, SR; Lee, KS; Lowinson, J, 1977)
"The course of pregnancy and delivery in 28 women under closely supervised methadone maintenance (group 1) was compared with that of 57 women using heroin or methadone under less controlled circumstances (group 2) and with that of 30 women free of mood-altering medications (group 3)."3.65Narcotic dependency in pregnancy. Methadone maintenance compared to use of street drugs. ( Adamsons, K; Stimmel, B, 1976)
"Immediate attention must be given to the respiratory system of the heroin abuser; then he should be given naloxone HCl."3.65Treating heroin overdose. ( Calabro, JJ; Neaderthal, RL, 1975)
" Morphine was detected in significant amounts in maternal and fetal urine regardless of whether the mother was on a methadone program or whether she denied any use of heroin during the last trimester of pregnancy."3.65A study of factors that influence the severity of neonatal narcotic withdrawal. ( Chavez, CJ; Ostrea, EM; Strauss, ME, 1975)
"Drug addiction during pregnancy has been managed in two ways: the detoxification program and the methadone-maintenance treatment program."3.65Drug addiction in pregnancy and the neonate. ( Ackerman, BD; Blinick, G; Jerez, E; Wallach, RC, 1976)
"Methadone use was associated with 21."1.91Opioid and Methadone Use for Infants With Surgically Treated Necrotizing Enterocolitis. ( Keane, OA; Kelley-Quon, LI; Kim, E; Kim, ES; Lakshmanan, A; Mahdi, EM; Ourshalimian, S; Song, AY; Zamora, AK, 2023)
"85% of the newborns had withdrawal symptoms and 12% had convulsions the severity of which was not correlated with the type of drug abuse."1.27Investigation of 89 children born by drug-dependent mothers. I. Neonatal course. ( Andersen, GE; Buckley, W; Friis-Hansen, B; Olofsson, M, 1983)
"The increased rate of prematurity, intrauterine growth retardation, and perinatal complications associated with perinatal exposure to cocaine or methamphetamine was greater than that predicted by coexisting risk factors and was consistent with the pharmacologic properties of these drugs."1.27Perinatal cocaine and methamphetamine exposure: maternal and neonatal correlates. ( Dixon, SD; Oro, AS, 1987)
"Thrombocytosis was not related to withdrawal symptoms or treatment (phenobarbital or paregoric)."1.26Thrombocytosis and increased circulating platelet aggregates in newborn infants of polydrug users. ( Burstein, Y; Giardina, PJ; Kandall, SR; Peterson, CM; Rausen, AR; Siljestrom, K, 1979)
" It is suggested that reduction of methadone dosage in late pregnancy results in reduced incidence of withdrawal but must be carefully carried out."1.26Observation and treatment of neonatal narcotic withdrawal. ( Chappel, JN; Davis, R; Gumpel, J; Madden, JD; Mejia, A; Zuspan, F, 1977)
"Neonatal withdrawal symptoms appear to be related to individual variation in maternal metabolism of the drug, placental transfer of methadone, and most importantly, to the individual variations in the rate of excretion of methadone as reflected in the neonatal plasma t 1/2."1.26Pharmacologic observations on the neonatal withdrawal syndrome. ( Pippenger, CE; Rosen, TS, 1976)
" No significant association was found between maternal dosage of methadone in the last trimester of pregnancy and lentth of gestation, birth weight, or the reported presence of withdrawal symptoms in the neonate."1.25Results of 313 consecutive live births of infants delivered to patients in the New York City Methadone Maintenance Treatment Program. ( Bashkow, S; Calko, D; Newman, RG, 1975)
"Several cases of chronic unsuspected infections in addicts' infants are reported, raising the question of the significance of undiagnosed infection as it affects growth."1.25Somatic growth effects of perinatal addiction. ( Wilson, GS, 1975)

Research

Studies (118)

TimeframeStudies, this research(%)All Research%
pre-1990110 (93.22)18.7374
1990's2 (1.69)18.2507
2000's3 (2.54)29.6817
2010's1 (0.85)24.3611
2020's2 (1.69)2.80

Authors

AuthorsStudies
Esposito, DB1
Huybrechts, KF1
Werler, MM1
Straub, L1
Hernández-Díaz, S1
Mogun, H1
Bateman, BT1
Keane, OA1
Zamora, AK1
Ourshalimian, S1
Mahdi, EM1
Song, AY1
Kim, E1
Lakshmanan, A1
Kim, ES1
Kelley-Quon, LI1
Dyer, O1
HILL, RM1
DESMOND, MM2
Sharpe, C1
Kuschel, C1
Wilson, GS3
Wait, RB1
Rosen, TS3
Johnson, HL1
Strauss, ME7
Reynolds, KS1
Dube, SK3
Jhaveri, RC3
Rosenfeld, W3
Evans, HE6
Khan, F3
Spergel, G1
Harris, VJ1
Srinivasan, G1
Carin, I1
Glass, L7
Parekh, A1
Solomon, N1
Steigman, J1
Wong, S1
Chasnoff, IJ4
Burns, WJ4
Schnoll, SH2
Marcus, J1
Hans, SL1
Jeremy, RJ1
Finnegan, LP7
Lin, TH1
Reeser, DS1
Shaffer, TH1
Delivoria-Papadopoulos, M1
Olofsson, M3
Buckley, W3
Andersen, GE3
Friis-Hansen, B3
Hatcher, R3
Amato, M1
Frei, H1
Bühlmann, U1
Aylward, GP1
Householder, J1
Burns, W1
Chasnoff, I1
Salazar, JD1
Chandavasu, O1
Dinges, DF1
Davis, MM3
Glass, P1
Bashore, RA1
Ketchum, JS1
Staisch, KJ1
Barrett, CT1
Zimmermann, EG1
Green, M2
Suffet, F2
Schaeffer, HA1
Rojansky, N1
Achiron, R1
Mintz, M1
Zakut, H1
Di Comite, A1
Saracino, P1
Tonti, R1
De Vita, L1
Kelly, JJ1
Davis, PG1
Henschke, PN1
Oei, J1
Feller, JM1
Lui, K1
Maykut, MO1
Fraser, AC1
Challis, RE1
Scopes, JW1
Dar, H1
Schmidt, R1
Nitowsky, HM1
Neumann, LL2
Cohen, SN2
Connaughton, JF2
Reeser, D1
Schut, J2
Ghodse, AH1
Reed, JL1
Mack, JW1
Burstein, Y1
Giardina, PJ1
Rausen, AR1
Kandall, SR4
Siljestrom, K1
Peterson, CM1
de Lange, EE1
Nathenson, G1
Zakrzewski, B1
Fleming, JW1
Rosser, P1
Silverman, I1
Taleporos, E1
Turkel, WV1
Kaltenbach, K1
Graziani, LJ1
Werblun, MN1
Cullison, SW1
Erickson, SH1
Albin, S2
Gartner, LM2
Lee, KS1
Eidelman, A1
Lowinson, J2
Goddard, J1
Madden, JD2
Davis, RC3
Chappel, JN3
Zuspan, F1
Gumpel, J1
Mejia, A1
Davis, R1
Oleske, JM1
Reveri, M1
Pyati, SP1
Pildes, RS2
Harper, RG5
Solish, G1
Feingold, E1
Gersten-Woolf, NB1
Sokal, MM1
Stimmel, B1
Adamsons, K1
Starr, RH2
Ostrea, EM4
Chavez, CJ3
Stryker, JC3
Soloway, IH1
Walters, DB1
Andresko, M2
Wardell, JN3
Newman, RG3
Bashkow, S1
Calko, D1
Blinick, G3
Inturrisi, CE1
Jerez, E3
Wallach, RC3
Rahbar, F1
Neaderthal, RL1
Calabro, JJ1
Zelson, C3
Pippenger, CE2
Emich, JP1
Shanks, B1
Lodge, A2
Marcus, MM1
Ramer, CM3
Dreyer, E1
Comstock, M1
Vargas, GC1
Vidyasagar, D1
Keith, LG1
Mejia-Zelaya, A1
Madden, J1
Kron, RE2
Litt, M2
Lessen-Firestone, JK1
Eng, D1
Phoenix, MD1
Ackerman, BD1
Lam, SK1
To, WK1
Duthie, SJ1
Ma, HK1
Sutton, LR1
Hinderliter, SA1
Oro, AS1
Dixon, SD1
Bohlin, AB1
Larsson, G1
Tunell, R1
Scanlon, JW1
Solish, GI2
Purow, HM1
Sang, E2
Panepinto, WC1
Dunkel, LD1
Soule, AB1
Standley, K1
Copans, SA1
Davis, M1
Lipsitz, PJ1
Blatman, S3
Thornton, WE1
Thornton, BP1
Kreek, MJ1
Schecter, A1
Gutjahr, CL1
Bowen, D1
Field, F1
Queenan, J1
Merkatz, I1
Waldmann, H1
Lee, SJ1
Casalino, M1
Sia, CG1
Blenman, S1
Purow, H1
Scott, NR1
Ryan, JJ1
Ramer, BS1
Webb, GA1
Mondanaro, J1
Brown, BS1
Glendinning, ST1
Rothstein, P1
Gould, JB1
Zavell, PM1
Statzer, DE1
Rajegowda, BK1
Masó, G1
Swartz, DP1
Leblanc, W1
Sullivan, RD1
Fischbach, AL1
Hornick, FW1
Annunziato, D1
Reddy, AM1
Stern, G1
Faller, W1
Berkelhamer, JE1
Esterly, JR1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot Randomized Comparative Effectiveness Clinical Trial of Buprenorphine vs. Methadone for the Treatment of Opioid Dependence in Pregnancy.[NCT03098407]55 participants (Actual)Interventional2017-04-20Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for methadone and Infant, Newborn, Diseases

ArticleYear
Psychological characteristics and development of narcotic-addicted infants.
    Drug and alcohol dependence, 1983, Volume: 12, Issue:4

    Topics: Child Behavior Disorders; Developmental Disabilities; Heroin; Humans; Infant, Newborn; Infant, Newbo

1983
Infants of drug-dependent mothers.
    Seminars in roentgenology, 1983, Volume: 18, Issue:3

    Topics: Abnormalities, Drug-Induced; Female; Fetal Alcohol Spectrum Disorders; Fetal Growth Retardation; Her

1983
The neonatal narcotic withdrawal syndrome: a therapeutic challenge.
    Clinics in perinatology, 1975, Volume: 2, Issue:1

    Topics: Barbiturates; Chlorpromazine; Diazepam; Humans; Infant Care; Infant, Newborn; Infant, Newborn, Disea

1975
The effect of maternal narcotic addiction on the newborn infant.
    Psychological medicine, 1977, Volume: 7, Issue:4

    Topics: Abnormalities, Drug-Induced; Breast Feeding; Female; Fertility; Heroin Dependence; Humans; Infant Mo

1977
Narcotic poisoning: a review of the literature.
    The American journal of psychiatry, 1974, Volume: 131, Issue:8

    Topics: Chemical and Drug Induced Liver Injury; Drug Contamination; Endocarditis; Heroin Dependence; Humans;

1974

Trials

1 trial available for methadone and Infant, Newborn, Diseases

ArticleYear
Neonatal methadone withdrawal. Effect of two treatment regimens.
    American journal of diseases of children (1960), 1983, Volume: 137, Issue:12

    Topics: Blood Pressure; Carbon Dioxide; Drug Administration Schedule; Female; Humans; Hydrogen-Ion Concentra

1983

Other Studies

112 other studies available for methadone and Infant, Newborn, Diseases

ArticleYear
Characteristics of Prescription Opioid Analgesics in Pregnancy and Risk of Neonatal Opioid Withdrawal Syndrome in Newborns.
    JAMA network open, 2022, 08-01, Volume: 5, Issue:8

    Topics: Adult; Analgesics, Opioid; Codeine; Cohort Studies; Female; Humans; Hydrocodone; Hydromorphone; Infa

2022
Opioid and Methadone Use for Infants With Surgically Treated Necrotizing Enterocolitis.
    JAMA network open, 2023, Jun-01, Volume: 6, Issue:6

    Topics: Analgesics, Opioid; Child; Cohort Studies; Enterocolitis, Necrotizing; Female; Humans; Infant; Infan

2023
US pledges better protection for babies born to addicts.
    BMJ (Clinical research ed.), 2016, Mar-22, Volume: 352

    Topics: Adult; Child of Impaired Parents; Child Protective Services; Female; Heroin Dependence; Humans; Infa

2016
Management of the narcotic withdrawal syndrome in the neonate.
    Pediatric clinics of North America, 1963, Volume: 10

    Topics: Barbiturates; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exc

1963
Outcomes of infants born to mothers receiving methadone for pain management in pregnancy.
    Archives of disease in childhood. Fetal and neonatal edition, 2004, Volume: 89, Issue:1

    Topics: Analgesics, Opioid; Chronic Disease; Delivery, Obstetric; Drug Administration Schedule; Female; Gest

2004
Follow-up of methadone-treated and untreated narcotic-dependent women and their infants: health, developmental, and social implications.
    The Journal of pediatrics, 1981, Volume: 98, Issue:5

    Topics: Adult; Developmental Disabilities; Female; Follow-Up Studies; Health Status; Humans; Infant; Infant,

1981
Children of methadone-maintained mothers: follow-up to 18 months of age.
    The Journal of pediatrics, 1982, Volume: 101, Issue:2

    Topics: Abnormalities, Drug-Induced; Developmental Disabilities; Female; Follow-Up Studies; Humans; Infant;

1982
Urinary catecholamines, plasma renin activity and blood pressure in newborns: effects of narcotic withdrawal.
    Developmental pharmacology and therapeutics, 1981, Volume: 3, Issue:2

    Topics: Catecholamines; Diastole; Female; Heroin; Humans; Hypertension; Infant, Newborn; Infant, Newborn, Di

1981
Perinatal addiction: the effects of maternal narcotic and nonnarcotic substance abuse on the fetus and neonate.
    NIDA research monograph, 1984, Volume: 49

    Topics: Adult; Arousal; Birth Weight; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, D

1984
The Moro reaction: a scoring system for neonatal narcotic withdrawal.
    Developmental medicine and child neurology, 1984, Volume: 26, Issue:4

    Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Pregnancy; Reflex, Startle; S

1984
Differential motor and state functioning in newborns of women on methadone.
    NIDA research monograph, 1982, Volume: 41

    Topics: Adolescent; Adult; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Pregnancy;

1982
The effects of perinatal addiction on pulmonary function in the newborn.
    NIDA research monograph, 1982, Volume: 41

    Topics: Birth Weight; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lung; M

1982
[Condition of 89 newborn infants of drug-addicted mothers].
    Ugeskrift for laeger, 1983, Feb-21, Volume: 145, Issue:8

    Topics: Abnormalities, Drug-Induced; Adult; Apgar Score; Female; Heroin Dependence; Humans; Infant, Low Birt

1983
Pentazocine and tripelennamine ('T's and blue's'): effects on the fetus and neonate.
    Developmental pharmacology and therapeutics, 1983, Volume: 6, Issue:3

    Topics: Adult; Female; Fetus; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Opioid-Related

1983
Investigation of 89 children born by drug-dependent mothers. I. Neonatal course.
    Acta paediatrica Scandinavica, 1983, Volume: 72, Issue:3

    Topics: Adult; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Infant, Small

1983
Investigation of 89 children born by drug-dependent mothers. II. Follow-up 1-10 years after birth.
    Acta paediatrica Scandinavica, 1983, Volume: 72, Issue:3

    Topics: Adult; Child; Child Behavior Disorders; Child, Institutionalized; Child, Preschool; Female; Follow-U

1983
[Drug withdrawal syndrome in the neonate].
    Schweizerische medizinische Wochenschrift, 1982, Mar-27, Volume: 112, Issue:13

    Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Psychotropic Drugs; Substance

1982
Methadone outcome studies: is it more than the methadone?
    The Journal of pediatrics, 1982, Volume: 101, Issue:2

    Topics: Abnormalities, Drug-Induced; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Met

1982
Polydrug- and methadone-addicted newborns: a continuum of impairment?
    Pediatrics, 1982, Volume: 70, Issue:2

    Topics: Abnormalities, Drug-Induced; Birth Weight; Child Behavior; Female; Heroin Dependence; Humans; Infant

1982
Infants born to narcotic-addicted mothers.
    Psychological bulletin, 1982, Volume: 92, Issue:2

    Topics: Child Development; Female; Heroin; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Metha

1982
Effects of methadone on thyroid function in mother, fetus, and newborn.
    Pediatrics, 1980, Volume: 65, Issue:3

    Topics: Adolescent; Adult; Age Factors; Female; Fetal Blood; Humans; Infant, Newborn; Infant, Newborn, Disea

1980
Fetal exposure to narcotics: neonatal sleep as a measure of nervous system disturbance.
    Science (New York, N.Y.), 1980, Aug-01, Volume: 209, Issue:4456

    Topics: Birth Weight; Female; Heroin; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases;

1980
Heroin addiction and pregnancy.
    The Western journal of medicine, 1981, Volume: 134, Issue:6

    Topics: Animals; Female; Fetal Diseases; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseas

1981
The Neonatal Narcotic Withdrawal Index: a device for the improvement of care in the abstinence syndrome.
    The American journal of drug and alcohol abuse, 1981, Volume: 8, Issue:2

    Topics: Female; Heroin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Opium; Pregnancy; Psy

1981
Relationship of thyroid hormone levels to the severity of the narcotic withdrawal syndrome.
    Developmental pharmacology and therapeutics, 1981, Volume: 3, Issue:4

    Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Pregnancy; Prospective

1981
[Newborn neonatal drug-withdrawal syndrome].
    Harefuah, 1981, Nov-01, Volume: 101, Issue:9

    Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Methadone; Opiu

1981
[Jaundice in the newborn infant of a "poly-drug-dependent" mother. Heroin and methadone, G6PDH deficiency and antagonism in the enzymatic modulation].
    Minerva pediatrica, 1980, Apr-15, Volume: 32, Issue:7

    Topics: Adult; Drug Antagonism; Female; Glucosephosphate Dehydrogenase Deficiency; Heroin Dependence; Humans

1980
The drug epidemic: effects on newborn infants and health resource consumption at a tertiary perinatal centre.
    Journal of paediatrics and child health, 2000, Volume: 36, Issue:3

    Topics: Adult; Ambulatory Care Facilities; Amphetamines; Australia; Benzodiazepines; Cannabis; Cocaine; Como

2000
Coordinated outpatient care of the narcotic-dependent infant.
    Journal of paediatrics and child health, 2001, Volume: 37, Issue:3

    Topics: Ambulatory Care; Child Health Services; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases;

2001
Pharmacotherapy of narcotic dependence.
    Progress in neuro-psychopharmacology, 1977, Volume: 1, Issue:1-2

    Topics: Buprenorphine; Cyclazocine; Dextropropoxyphene; Diphenoxylate; Female; Humans; Infant, Newborn; Infa

1977
Drug addiction in pregnancy.
    Lancet (London, England), 1976, Oct-23, Volume: 2, Issue:7991

    Topics: Adult; Female; Follow-Up Studies; Heroin; Heroin Dependence; Humans; Infant, Newborn; Infant, Newbor

1976
Late withdrawal symptoms in babies born to methadone addicts.
    Lancet (London, England), 1977, Dec-10, Volume: 2, Issue:8050

    Topics: Adult; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal

1977
Palmar crease variants and their clinical significance: a study of newborns at risk.
    Pediatric research, 1977, Volume: 11, Issue:2

    Topics: Adult; Age Factors; Child; Child, Preschool; Dermatoglyphics; Down Syndrome; Female; Fetus; Hand; Hu

1977
Management of pregnant drug-dependent women.
    Annals of the New York Academy of Sciences, 1978, Volume: 311

    Topics: Family Therapy; Female; Heroin Dependence; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant

1978
Perinatal addiction: outcome and management.
    American journal of obstetrics and gynecology, 1977, Nov-15, Volume: 129, Issue:6

    Topics: Abruptio Placentae; Apgar Score; Breech Presentation; Cesarean Section; Counseling; Female; Fetal Gr

1977
Thrombocytosis and increased circulating platelet aggregates in newborn infants of polydrug users.
    The Journal of pediatrics, 1979, Volume: 94, Issue:6

    Topics: Amphetamine; Cocaine; Diazepam; Female; Heroin Dependence; Humans; Infant; Infant, Newborn; Infant,

1979
[The effect of heroin and methadone on pregnancy and the newborn infant].
    Nederlands tijdschrift voor geneeskunde, 1979, Jul-07, Volume: 123, Issue:27

    Topics: Female; Fetus; Heroin; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Labor,

1979
Perinatal drug abuse.
    Pediatric annals, 1979, Volume: 8, Issue:2

    Topics: Amphetamines; Barbiturates; Cannabis; Cocaine; Female; Fetal Alcohol Spectrum Disorders; Heroin Depe

1979
Urinary excretion of methadone during neonatal withdrawal: clinical application.
    The International journal of the addictions, 1979, Volume: 14, Issue:4

    Topics: Age Factors; Dose-Response Relationship, Drug; Hemagglutination Inhibition Tests; Humans; Infant, Ne

1979
The congenitally methadone-addicted infant.
    Birth defects original article series, 1979, Volume: 15, Issue:7

    Topics: Child Development; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchan

1979
Outcomes of pregnancy for addicts receiving comprehensive care.
    The American journal of drug and alcohol abuse, 1979, Volume: 6, Issue:4

    Topics: Adult; Bilirubin; Birth Weight; Comprehensive Health Care; Female; Gestational Age; Humans; Infant,

1979
Methadone exposure in utero: developmental status at one and two years of age.
    Pharmacology, biochemistry, and behavior, 1979, Volume: 11 Suppl

    Topics: Aging; Female; Growth; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Intelligence Test

1979
Narcotic abuse in pregnancy.
    The Journal of family practice, 1979, Volume: 9, Issue:4

    Topics: Adult; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Pre

1979
The narcotic-dependent mother: fetal and neonatal consequences.
    Early human development, 1977, Volume: 1, Issue:2

    Topics: Adult; Female; Fetal Death; Fetus; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn; Inf

1977
Management of neonatal drug withdrawal.
    The Journal of pediatrics, 1978, Volume: 92, Issue:5

    Topics: Diazepam; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Seizures

1978
Problems pertaining to the care of newborn infants of drug-addicted women.
    The Journal of reproductive medicine, 1978, Volume: 20, Issue:6

    Topics: Apnea; Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Narcotics; P

1978
Psychosocial care of the pregnant narcotic addict.
    The Journal of reproductive medicine, 1978, Volume: 20, Issue:6

    Topics: Behavior Therapy; Female; Heroin Dependence; Humans; Infant, Low Birth Weight; Infant, Newborn; Infa

1978
Observation and treatment of neonatal narcotic withdrawal.
    American journal of obstetrics and gynecology, 1977, Jan-15, Volume: 127, Issue:2

    Topics: Diazepam; Drug Therapy, Combination; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, New

1977
Experiences with 118 infants born to narcotic-using mothers. Does a lowered serum-ionized calcium level contribute to the symptoms of withdrawal?
    Clinical pediatrics, 1977, Volume: 16, Issue:5

    Topics: Calcium; Female; Follow-Up Studies; Heroin Dependence; Humans; Infant, Low Birth Weight; Infant, New

1977
Neonatal withdrawal symptoms associated with glutethimide (Doriden) addiction in the mother during pregnancy.
    Clinical pediatrics, 1977, Volume: 16, Issue:5

    Topics: Female; Glutethimide; Heroin Dependence; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant,

1977
Maternal ingested methadone, body fluid methadone, and the neonatal withdrawal syndrome.
    American journal of obstetrics and gynecology, 1977, Oct-15, Volume: 129, Issue:4

    Topics: Amniotic Fluid; Body Fluids; Female; Fetal Blood; Fetus; Heroin Dependence; Humans; Infant, Newborn;

1977
Narcotic dependency in pregnancy. Methadone maintenance compared to use of street drugs.
    JAMA, 1976, Mar-15, Volume: 235, Issue:11

    Topics: Adolescent; Adult; Apgar Score; Birth Weight; Child, Preschool; Female; Follow-Up Studies; Heroin De

1976
Behavioural concomitants of prenatal addiction to narcotics.
    The Journal of pediatrics, 1976, Volume: 89, Issue:5

    Topics: Child Development; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Feta

1976
Neonatal drug dependence: developmental and bio-cultural considerations.
    Addictive diseases, 1976, Volume: 2, Issue:4

    Topics: Birth Weight; Family Characteristics; Female; Fetus; Humans; Infant Mortality; Infant, Newborn; Infa

1976
Relationship of neonatal withdrawal to maternal methadone dose.
    The American journal of drug and alcohol abuse, 1976, Volume: 3, Issue:2

    Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Preg

1976
Results of 313 consecutive live births of infants delivered to patients in the New York City Methadone Maintenance Treatment Program.
    American journal of obstetrics and gynecology, 1975, Jan-15, Volume: 121, Issue:2

    Topics: Adolescent; Adult; Apgar Score; Birth Weight; Drug and Narcotic Control; Female; Fetus; Follow-Up St

1975
Methadone assays in pregnant women and progeny.
    American journal of obstetrics and gynecology, 1975, Mar-01, Volume: 121, Issue:5

    Topics: Amniotic Fluid; Chromatography, Gas; Female; Fetus; Heroin Dependence; Humans; Infant, Newborn; Infa

1975
Observations on methadone withdrawal in 16 neonates.
    Clinical pediatrics, 1975, Volume: 14, Issue:4

    Topics: Adolescent; Adult; Birth Weight; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn

1975
Treating heroin overdose.
    American family physician, 1975, Volume: 11, Issue:2

    Topics: Arrhythmias, Cardiac; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Emer

1975
Acute management of neonatal addiction.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Antidiarrheals; Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant

1975
Disposition of methadone and its relationship to severity of withdrawal in the newborn.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Administration, Oral; Chromatography, Gas; Dose-Response Relationship, Drug; Female; Fetal Blood; Ha

1975
A study of factors that influence the severity of neonatal narcotic withdrawal.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Administration, Oral; Bilirubin; Birth Weight; Body Weight; Dose-Response Relationship, Drug; Enviro

1975
Current concepts in the management of the pregnant opiate addict.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Administration, Oral; Anesthesia, Conduction; Anesthesia, Obstetrical; Birth Weight; Counseling; Fem

1975
Neurological aspects of perinatal narcotic addiction and methadone treatment.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Auditory Perception; Autonomic Nervous System; Birth Weight; Central Nervous System Diseases; Child

1975
Part II. Behavioral and electrophysiological characteristics of the addicted neonate.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Acoustic Stimulation; Arousal; Attention; Birth Weight; Electrophysiology; Evoked Potentials; Female

1975
Neonatal addiction: a two-year study. Part I. Clinical and developmental characteristics of infants of mothers on methadone maintenance.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Administration, Oral; Age Factors; Attention; Birth Weight; Child Development; Diazepam; Dose-Respon

1975
Somatic growth effects of perinatal addiction.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Birth Weight; Cephalometry; Child; Child Development; Child Nutritional Physiological Phenomena; Chi

1975
Differential effects of heroin and methadone on birth weights.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Birth Weight; Dose-Response Relationship, Drug; Female; Fetus; Gestational Age; Heroin Dependence; H

1975
Effect of maternal heroin addiction on 67 liveborn neonates. Withdrawal symptoms, small body size, and small head circumference were frequent findings.
    Clinical pediatrics, 1975, Volume: 14, Issue:8

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Birth Weight; Blood Glucose; Cephalomet

1975
Clinical observations on methadone-maintained pregnancies.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Administration, Oral; Adult; Birth Weight; Counseling; Dose-Response Relationship, Drug; Female; Fet

1975
Narcotic addiction in the newborn: differences in behavior generated by methadone and heroin.
    International journal of clinical pharmacology and biopharmacy, 1975, Volume: 12, Issue:1-2

    Topics: Adaptation, Physiological; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, New

1975
Behavior of narcotics-addicted newborns.
    Child development, 1975, Volume: 46, Issue:4

    Topics: Adult; Attention; Female; Habituation, Psychophysiologic; Heroin; Humans; Infant, Newborn; Infant, N

1975
Neonatal narcotic abstinence: Effects of pharmacotherapeutic agents and maternal drug usage on nutritive sucking behavior.
    The Journal of pediatrics, 1976, Volume: 88, Issue:4 Pt 1

    Topics: Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Opium; Phenob

1976
A study of factors that influence the severity of neonatal narcotic withdrawal.
    The Journal of pediatrics, 1976, Volume: 88, Issue:4 Pt 1

    Topics: Apgar Score; Female; Gestational Age; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lighting;

1976
Drug addiction in pregnancy and the neonate.
    American journal of obstetrics and gynecology, 1976, May-15, Volume: 125, Issue:2

    Topics: Alcoholic Intoxication; Birth Weight; Diazepam; Female; Heroin Dependence; Hospitalization; Humans;

1976
Pharmacologic observations on the neonatal withdrawal syndrome.
    The Journal of pediatrics, 1976, Volume: 88, Issue:6

    Topics: Female; Half-Life; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Kinetics;

1976
Narcotic addiction in pregnancy with adverse maternal and perinatal outcome.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1992, Volume: 32, Issue:3

    Topics: Adult; Female; Fetal Growth Retardation; Heroin Dependence; Hong Kong; Humans; Infant, Low Birth Wei

1992
Diazepam abuse in pregnant women on methadone maintenance. Implications for the neonate.
    Clinical pediatrics, 1990, Volume: 29, Issue:2

    Topics: Adult; Diazepam; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Infant, Newborn, Diseas

1990
Perinatal cocaine and methamphetamine exposure: maternal and neonatal correlates.
    The Journal of pediatrics, 1987, Volume: 111, Issue:4

    Topics: Apgar Score; Birth Weight; Child Behavior; Cocaine; Female; Fetal Growth Retardation; Gestational Ag

1987
[Withdrawal symptoms and behavioral disorders in children of mothers taking heroin/methadone during pregnancy].
    Lakartidningen, 1985, Aug-07, Volume: 82, Issue:32-33

    Topics: Adult; Child Behavior Disorders; Child Development; Child, Preschool; Female; Follow-Up Studies; Her

1985
Letter: Pentazocine and neonatal withdrawal symptoms.
    The Journal of pediatrics, 1974, Volume: 85, Issue:5

    Topics: Female; Glutethimide; Humans; Infant, Newborn; Infant, Newborn, Diseases; Long-Term Care; Maternal-F

1974
Infant of the addicted mother.
    The New England journal of medicine, 1973, Jun-28, Volume: 288, Issue:26

    Topics: Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Disea

1973
The effect of a methadone treatment program upon pregnant heroin addicts and their newborn infants.
    Pediatrics, 1974, Volume: 54, Issue:3

    Topics: Adult; Birth Weight; Blood Glucose; Calcium; Female; Fetus; Gestational Age; Heroin Dependence; Huma

1974
Methadone maintenance during pregnancy: pregnancy, birth, and neonate characteristics.
    American journal of obstetrics and gynecology, 1974, Dec-01, Volume: 120, Issue:7

    Topics: Adolescent; Adult; Apgar Score; Birth Weight; Female; Gestational Age; Heroin Dependence; Humans; In

1974
Clinical uses of the Brazelton Neonatal Scale.
    Pediatrics, 1974, Volume: 54, Issue:5

    Topics: Child Behavior; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Metha

1974
Pregnancies of methadone patients. Findings in New York City Methadone Maintenance Treatment Program.
    New York state journal of medicine, 1974, Volume: 74, Issue:1

    Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases;

1974
Newborn infants of mothers on methadone maintenance.
    New York state journal of medicine, 1974, Volume: 74, Issue:6

    Topics: Body Weight; Camphor; Diazepam; Female; Gestational Age; Humans; Infant, Newborn; Infant, Newborn, D

1974
Analyses of methadone and other drugs in maternal and neonatal body fluids: use in evaluation of symptoms in a neonate of mother maintained on methadone.
    The American journal of drug and alcohol abuse, 1974, Volume: 1, Issue:3

    Topics: Adult; Amniotic Fluid; Body Fluids; Escherichia coli Infections; Female; Fetal Blood; Heroin Depende

1974
Methadone maintenance, pregnancy, and progeny.
    JAMA, 1973, Jul-30, Volume: 225, Issue:5

    Topics: Administration, Oral; Adult; Apgar Score; Birth Weight; Female; Fetal Death; Heroin; Heroin Dependen

1973
[Psychiatric emergencies during pregnancy and in the puerperium].
    Munchener medizinische Wochenschrift (1950), 1973, Jun-01, Volume: 115, Issue:22

    Topics: Amphetamine; Cannabis; Emergencies; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lyse

1973
Neonatal narcotic addiction. Comparative effects of maternal intake of heroin and methadone.
    The New England journal of medicine, 1973, Dec-06, Volume: 289, Issue:23

    Topics: Adult; Apgar Score; Birth Weight; Chlorpromazine; Female; Gestational Age; Heroin Dependence; Humans

1973
Methadone maintenance during pregnancy.
    American journal of diseases of children (1960), 1973, Volume: 126, Issue:4

    Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Pregnancy;

1973
Results of 120 deliveries of patients in the New York City methadone maintenance treatment program.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2

    Topics: Adolescent; Adult; Birth Weight; Delivery, Obstetric; Demography; Ethnicity; Female; Heroin Dependen

1973
Observations on the sudden death of infants born to addicted mothers.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2

    Topics: Adult; Death, Sudden; Female; Heroin Dependence; Humans; Infant; Infant Mortality; Infant, Newborn;

1973
The effect of a methadone treatment program upon pregnant addicts and their infants.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2

    Topics: Adult; Apgar Score; Female; Hepatitis; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn;

1973
Clinical evaluation of pregnant methadone maintenance patients and their newborn infants.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2

    Topics: Adolescent; Adult; Community Health Services; Evaluation Studies as Topic; Female; Heroin Dependence

1973
Treatment experiences with the pregnant addict.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2

    Topics: Adolescent; Adult; Amniotic Fluid; Female; Gestational Age; Hepatitis; Heroin Dependence; Humans; In

1973
Neonatal effects of heroin addiction and methadone-treated pregnancies. Preliminary report on 70 live births.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2

    Topics: Adult; Birth Weight; Dose-Response Relationship, Drug; Female; Heroin Dependence; Humans; Infant, Ne

1973
Pregnancy in the context of narcotic addiction and methadone maintenance.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2

    Topics: Adult; Alcoholism; Barbiturates; Chicago; Female; Heroin Dependence; Humans; Infant Mortality; Infan

1973
Methadone effects on pregnancy and the newborn.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2

    Topics: Adolescent; Adult; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Ma

1973
Late presentation of drug withdrawal symptoms in newborns.
    American journal of diseases of children (1960), 1974, Volume: 127, Issue:1

    Topics: Birth Weight; Camphor; Diazepam; Female; Gestational Age; Heroin Dependence; Humans; Infant; Infant,

1974
Narcotic withdrawal in the newborn infant.
    Journal of the National Medical Association, 1974, Volume: 66, Issue:2

    Topics: Diazepam; Female; Fetus; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Mate

1974
Born with a habit. Infants of drug-addicted mothers.
    Pediatric clinics of North America, 1974, Volume: 21, Issue:2

    Topics: Abnormalities, Drug-Induced; Adult; Age Factors; Barbiturates; Camphor; Chlorpromazine; Codeine; Dia

1974
Perinatal tips.
    Michigan medicine, 1974, Volume: 73, Issue:9

    Topics: Chlorpromazine; Education, Medical, Continuing; Female; Humans; Infant, Newborn; Infant, Newborn, Di

1974
Heroin addiction during pregnancy.
    American journal of obstetrics and gynecology, 1972, May-15, Volume: 113, Issue:2

    Topics: Adolescent; Adult; Amniocentesis; Bilirubin; Birth Weight; Female; Gestational Age; Heroin; Humans;

1972
Methadone withdrawal in newborn infants.
    The Journal of pediatrics, 1972, Volume: 81, Issue:3

    Topics: Female; Gestational Age; Heroin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Maternal-

1972
Treatment of a pregnant opiate addict with oral methadone.
    Arizona medicine, 1972, Volume: 29, Issue:2

    Topics: Administration, Oral; Adult; Female; Heroin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Met

1972
Narcotic withdrawal in the newborn.
    American family physician, 1972, Volume: 6, Issue:1

    Topics: Birth Weight; Chlorpromazine; Cocaine; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, N

1972
Neonatal addiction to methadone.
    Pediatrics, 1971, Volume: 47, Issue:4

    Topics: Female; Heroin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Methado

1971
Observations on heroin and methadone withdrawal in the newborn.
    Pediatrics, 1971, Volume: 48, Issue:3

    Topics: Adolescent; Adult; Apgar Score; Birth Weight; Female; Heroin; Humans; Infant, Newborn; Infant, Newbo

1971
Neonatal biliary tract infection coincident with maternal methadone therapy.
    Pediatrics, 1971, Volume: 48, Issue:6

    Topics: Adult; Cholangitis; Cholecystitis; Female; Heroin; Humans; Infant, Newborn; Infant, Newborn, Disease

1971
Methadone and children.
    Pediatrics, 1971, Volume: 48, Issue:2

    Topics: Adolescent; Adult; Child, Preschool; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Mat

1971