Page last updated: 2024-10-30

methadone and Impotence

methadone has been researched along with Impotence in 21 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Research Excerpts

ExcerptRelevanceReference
"While methadone effectively treats opiate dependence, the side effect of erectile dysfunction (ED) may interfere with treatment adherence and benefits."7.79Risk factors of erectile dysfunction in patients receiving methadone maintenance therapy. ( Abdul Aziz, S; Baharudin, A; Das, S; Ibrahim, N; Midin, M; Mislan, N; Nik Jaafar, NR; Sidi, H, 2013)
"Erectile dysfunction (ED) is common among methadone-maintained patients and reduces their quality of life."7.78Erectile dysfunction among male heroin addicts receiving methadone maintenance treatment in Guangdong, China. ( Chen, J; Chen, W; He, Q; Li, X; Ling, L; Xia, Y, 2012)
"While methadone effectively treats opiate dependence, the side effect of erectile dysfunction (ED) may interfere with treatment adherence and benefits."3.79Risk factors of erectile dysfunction in patients receiving methadone maintenance therapy. ( Abdul Aziz, S; Baharudin, A; Das, S; Ibrahim, N; Midin, M; Mislan, N; Nik Jaafar, NR; Sidi, H, 2013)
"Erectile dysfunction (ED) is common among methadone-maintained patients and reduces their quality of life."3.78Erectile dysfunction among male heroin addicts receiving methadone maintenance treatment in Guangdong, China. ( Chen, J; Chen, W; He, Q; Li, X; Ling, L; Xia, Y, 2012)
"Bupropion is a dopamine reuptake inhibitor which can potentially improve erectile function among male patients on methadone (MMT)."2.87Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Trial of Bupropion as Treatment for Methadone-Emergent Sexual Dysfunction in Men. ( Loh, HS; Ng, CG; Ong, TA; Sulaiman, AH; Yee, A, 2018)
"Methadone has long been regarded as an effective treatment for opioid dependence."1.43Sexual Dysfunction in Heroin Dependents: A Comparison between Methadone and Buprenorphine Maintenance Treatment. ( Danaee, M; Loh, HS; Ng, CG; Sulaiman, AH; Yee, A, 2016)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19907 (33.33)18.7374
1990's0 (0.00)18.2507
2000's4 (19.05)29.6817
2010's10 (47.62)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ramli, FF1
Shuid, AN1
Pakri Mohamed, RM1
Tg Abu Bakar Sidik, TMI1
Naina Mohamed, I1
Lugoboni, F2
Zamboni, L1
Federico, A1
Tamburin, S1
Seftel, AD1
Yee, A2
Loh, HS2
Ong, TA1
Ng, CG2
Sulaiman, AH2
Nik Jaafar, NR1
Mislan, N1
Abdul Aziz, S1
Baharudin, A1
Ibrahim, N1
Midin, M1
Das, S1
Sidi, H1
Danaee, M1
Vecchierini, MF1
Laaban, JP1
Desjobert, M1
Gagnadoux, F1
Chabolle, F1
Meurice, JC1
Sapène, M1
Serrier, P1
Lévy, P1
Zhang, Y1
Wang, P1
Ma, Z1
Xu, Z1
Li, Y1
Chen, W1
Li, X2
Ling, L1
Xia, Y1
Chen, J1
He, Q1
Babakhanian, M1
Alam Mehrjerdi, Z1
Shenaiy, Y1
Brown, R1
Balousek, S1
Mundt, M1
Fleming, M1
Highleyman, L1
Quaglio, G1
Pattaro, C1
Melara, B1
Mezzelani, P1
Des Jarlais, DC1
Hallinan, R1
Byrne, A1
Agho, K1
McMahon, C1
Tynan, P1
Attia, J1
Hanbury, R1
Cohen, M1
Stimmel, B2
Crowley, TJ1
Simpson, R1
Cicero, TJ1
Bell, RD1
Wiest, WG1
Allison, JH1
Polakoski, K1
Robins, E1
Chappel, JN1
Mintz, J1
O'Hare, K1
O'Brien, CP1
Goldschmidt, J1
Espejo, R1
Hogben, G1
Cassidy, WJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Analgesic Efficacy of Testosterone Replacement in Hypogonadal Opioid-treated Chronic Pain Patients: A Pilot Study.[NCT00398034]Phase 20 participants (Actual)Interventional2006-10-30Withdrawn (stopped due to The original PI (David Siegel) Left the VA)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for methadone and Impotence

ArticleYear
Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Trial of Bupropion as Treatment for Methadone-Emergent Sexual Dysfunction in Men.
    American journal of men's health, 2018, Volume: 12, Issue:5

    Topics: Adult; Bupropion; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedul

2018

Other Studies

20 other studies available for methadone and Impotence

ArticleYear
Health-Seeking Behavior for Erectile Dysfunction in Methadone Maintenance Treatment Patients.
    International journal of environmental research and public health, 2019, 11-01, Volume: 16, Issue:21

    Topics: Adult; Drug Users; Erectile Dysfunction; Health Behavior; Humans; Malaysia; Male; Methadone; Middle

2019
Erectile dysfunction and quality of life in men receiving methadone or buprenorphine maintenance treatment. A cross-sectional multicentre study.
    PloS one, 2017, Volume: 12, Issue:11

    Topics: Adolescent; Adult; Aged; Buprenorphine; Cross-Sectional Studies; Erectile Dysfunction; Humans; Male;

2017
Re: Erectile Dysfunction and Quality of Life in Men Receiving Methadone or Buprenorphine Maintenance Treatment. A Cross-Sectional Multicentre Study.
    The Journal of urology, 2018, Volume: 199, Issue:5

    Topics: Buprenorphine; Cross-Sectional Studies; Erectile Dysfunction; Humans; Male; Methadone; Quality of Li

2018
Risk factors of erectile dysfunction in patients receiving methadone maintenance therapy.
    The journal of sexual medicine, 2013, Volume: 10, Issue:8

    Topics: Adult; Aged; Erectile Dysfunction; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders; R

2013
Sexual Dysfunction in Heroin Dependents: A Comparison between Methadone and Buprenorphine Maintenance Treatment.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Adult; Buprenorphine; Cross-Sectional Studies; Erectile Dysfunction; Heroin Dependence; Humans; Main

2016
[Therapeutic strategies of obstructive sleep apnea syndrome integrating combined treatments?].
    Revue des maladies respiratoires, 2010, Volume: 27 Suppl 3

    Topics: Alcohol Drinking; Benzodiazepines; Combined Modality Therapy; Continuous Positive Airway Pressure; E

2010
Sexual function of 612 male addicts treated by methadone.
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2011, Volume: 36, Issue:8

    Topics: Adult; Erectile Dysfunction; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Substance With

2011
Erectile dysfunction among male heroin addicts receiving methadone maintenance treatment in Guangdong, China.
    Journal of addiction medicine, 2012, Volume: 6, Issue:3

    Topics: Adult; China; Comorbidity; Dose-Response Relationship, Drug; Erectile Dysfunction; Heroin Dependence

2012
Sexual dysfunction in male crystalline heroin dependents before and after MMT: a pilot study.
    Archives of Iranian medicine, 2012, Volume: 15, Issue:12

    Topics: Adult; Erectile Dysfunction; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Pilot Projects

2012
Methadone maintenance and male sexual dysfunction.
    Journal of addictive diseases, 2005, Volume: 24, Issue:2

    Topics: Adult; Demography; Erectile Dysfunction; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Rel

2005
Drug interactions and anti-HIV therapy.
    BETA : bulletin of experimental treatments for AIDS : a publication of the San Francisco AIDS Foundation, 2005,Summer, Volume: 17, Issue:4

    Topics: AIDS-Related Opportunistic Infections; Anti-HIV Agents; Anticholesteremic Agents; Contraceptives, Or

2005
Erectile dysfunction in male heroin users, receiving methadone and buprenorphine maintenance treatment.
    Drug and alcohol dependence, 2008, Apr-01, Volume: 94, Issue:1-3

    Topics: Adolescent; Adult; Buprenorphine; Depression; Erectile Dysfunction; Heroin Dependence; Humans; Male;

2008
Erectile dysfunction in men receiving methadone and buprenorphine maintenance treatment.
    The journal of sexual medicine, 2008, Volume: 5, Issue:3

    Topics: Adult; Age Factors; Buprenorphine; Depression; Dose-Response Relationship, Drug; Erectile Dysfunctio

2008
Adequacy of sexual performance in men maintained on methadone.
    The American journal of drug and alcohol abuse, 1977, Volume: 4, Issue:1

    Topics: Adult; Ejaculation; Erectile Dysfunction; Female; Humans; Libido; Male; Methadone; Sexual Dysfunctio

1977
Methadone dose and human sexual behavior.
    The International journal of the addictions, 1978, Volume: 13, Issue:2

    Topics: Adult; Dose-Response Relationship, Drug; Ejaculation; Erectile Dysfunction; Female; Heroin Dependenc

1978
Function of the male sex organs in heroin and methadone users.
    The New England journal of medicine, 1975, Apr-24, Volume: 292, Issue:17

    Topics: Adult; Cell Count; Cell Movement; Ejaculation; Erectile Dysfunction; Genitalia, Male; Heroin Depende

1975
Methadone and chemotherapy in drug addiction. Genocidal or lifesaving?
    JAMA, 1974, May-06, Volume: 228, Issue:6

    Topics: Alcoholics Anonymous; Erectile Dysfunction; Ethics; Evaluation Studies as Topic; Follow-Up Studies;

1974
Sexual problems of heroin addicts.
    Archives of general psychiatry, 1974, Volume: 31, Issue:5

    Topics: Adult; Age Factors; Black or African American; Educational Status; Ejaculation; Erectile Dysfunction

1974
Sexual performance of men on methadone maintenance.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 1

    Topics: Adult; Alcoholism; Erectile Dysfunction; Heroin Dependence; Humans; Male; Methadone

1973
Maintenance methadone treatment of drug dependency.
    Canadian Psychiatric Association journal, 1972, Volume: 17, Issue:2

    Topics: Administration, Oral; Adult; Constipation; Erectile Dysfunction; Evaluation Studies as Topic; Female

1972