methadone has been researched along with Hypokalemia in 4 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Hypokalemia: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the relationship between the daily dose of the synthetic opioid methadone and the corrected QT (QTc) interval in a series of methadone-treated patients who developed torsade de pointes." | 7.72 | Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes. ( Krantz, MJ; Kutinsky, IB; Mehler, PS; Robertson, AD, 2003) |
| "Nearly 20 studies showed a prolonged QT interval secondary to methadone in patients exhibiting the following features: (1) patients with cardiac pathologies, notably bradycardia, congenital long QT interval, myocardial pathologies related to AIDS and electrolyte disturbances; (2) patients receiving concomitant treatment with substances known to prolong QT interval, such as psychoactive stimulants, narcoleptics, tricyclic antidepressants, antiarrhythmic agents, macrolids, quinolones, non diuretic hypokalemiants and certain corticoids; (3) patients receiving treatments that inhibit methadone's metabolism, particularly those that act on the cytochrome P450 3A4 such as SSRI, antifungal agents, some macrolids and some retroviral agents." | 4.88 | [Review of cases of prolonged QTC and wave burst arrhythmia in patients treated with methadone]. ( Berleur, MP; Kerbage, H; Laqueille, X; Richa, S; Scart-Gres, C, 2012) |
| "To investigate the relationship between the daily dose of the synthetic opioid methadone and the corrected QT (QTc) interval in a series of methadone-treated patients who developed torsade de pointes." | 3.72 | Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes. ( Krantz, MJ; Kutinsky, IB; Mehler, PS; Robertson, AD, 2003) |
| "(1) Methadone is an opiate used for replacement therapy of opiate addiction that causes dose-dependent QT prolongation." | 1.33 | Torsades de pointes with methadone. ( , 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Laqueille, X | 1 |
| Richa, S | 1 |
| Kerbage, H | 1 |
| Scart-Gres, C | 1 |
| Berleur, MP | 1 |
| Krantz, MJ | 1 |
| Kutinsky, IB | 1 |
| Robertson, AD | 1 |
| Mehler, PS | 1 |
| Justo, D | 1 |
| Gal-Oz, A | 1 |
| Paran, Y | 1 |
| Goldin, Y | 1 |
| Zeltser, D | 1 |
1 review available for methadone and Hypokalemia
| Article | Year |
|---|---|
[Review of cases of prolonged QTC and wave burst arrhythmia in patients treated with methadone].
Topics: Adult; Analgesics, Opioid; Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Drug Interactio | 2012 |
3 other studies available for methadone and Hypokalemia
| Article | Year |
|---|---|
Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes.
Topics: Adult; Aged; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Hypokalemia; Lon | 2003 |
Torsades de pointes with methadone.
Topics: Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Drug Interactions; Heroin; Humans; Hypokalemia; L | 2005 |
Methadone-associated Torsades de Pointes (polymorphic ventricular tachycardia) in opioid-dependent patients.
Topics: Adult; Female; Heroin Dependence; Humans; Hypokalemia; Methadone; Middle Aged; Narcotics; Renal Insu | 2006 |