Page last updated: 2024-10-30

methadone and Hepatitis A

methadone has been researched along with Hepatitis A in 10 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Hepatitis A: INFLAMMATION of the LIVER in humans caused by a member of the HEPATOVIRUS genus, HUMAN HEPATITIS A VIRUS. It can be transmitted through fecal contamination of food or water.

Research Excerpts

ExcerptRelevanceReference
"The survey of viral infections in the liver investigated by means of serological markers of hepatitis A, B and C in drug addicts on methadone maintenance treatment is important for the next procedures."7.72[Prevalence of serological markers of viral hepatitis B and hepatitis C in drug-dependent individuals treated at the Drop Methadone Center in Prague]. ( Urbánek, P; Wilczek, H, 2003)
"We evaluated the efficacy of a hepatitis care coordination intervention to improve linkage to hepatitis A virus (HAV) and hepatitis B virus (HBV) vaccination and clinical evaluation of hepatitis C virus (HCV) infection among methadone maintenance patients."5.17A randomized trial of a hepatitis care coordination model in methadone maintenance treatment. ( Bodenheimer, HC; Coffin, L; Delucchi, KL; Des Jarlais, DC; Hall, J; Hammer, H; Hengl, NS; Hettema, J; Jordan, AE; Khalili, M; Manuel, JK; Masson, CL; McKnight, C; Min, A; Pepper, N; Perlman, DC; Seewald, RM; Shapiro, B; Shopshire, MS; Sorensen, JL; Young, C, 2013)
"This randomized, controlled study (n = 256) was conducted to compare three interventions designed to promote hepatitis A virus (HAV) and hepatitis B virus (HBV) vaccination completion, among clients undergoing methadone maintenance treatment (MMT) in Los Angeles and Santa Monica."5.14Predictors of hepatitis knowledge improvement among methadone maintained clients enrolled in a hepatitis intervention program. ( Cohen, A; Greengold, B; Marfisee, M; Nyamathi, A; Sinha, K; Tyler, D, 2010)
"The survey of viral infections in the liver investigated by means of serological markers of hepatitis A, B and C in drug addicts on methadone maintenance treatment is important for the next procedures."3.72[Prevalence of serological markers of viral hepatitis B and hepatitis C in drug-dependent individuals treated at the Drop Methadone Center in Prague]. ( Urbánek, P; Wilczek, H, 2003)
" Among 42 active heroin users or former heroin addicts maintained on methadone, 79% were heavy alcohol abusers."3.65The spectrum and causes of liver diseases in narcotic addicts. ( Gelb, AM; Mildvan, D; Stenger, RJ, 1977)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19904 (40.00)18.7374
1990's0 (0.00)18.2507
2000's2 (20.00)29.6817
2010's4 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Masson, CL3
Delucchi, KL2
McKnight, C3
Hettema, J2
Khalili, M2
Min, A2
Jordan, AE3
Pepper, N1
Hall, J1
Hengl, NS1
Young, C3
Shopshire, MS2
Manuel, JK1
Coffin, L1
Hammer, H1
Shapiro, B1
Seewald, RM2
Bodenheimer, HC1
Sorensen, JL3
Des Jarlais, DC3
Perlman, DC3
Larios, SE1
Hengl, N1
Nyamathi, A1
Tyler, D1
Sinha, K1
Marfisee, M1
Cohen, A1
Greengold, B1
Wilczek, H1
Urbánek, P1
Tennant, F1
Gelb, AM1
Mildvan, D1
Stenger, RJ1
Clark, MO1
Lewis, JF1
Stimmel, B1
Vernace, S1
Heller, E1
Tobias, H1
Arroyave, F1
Little, D1
Letemendia, F1
De Alarcon, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Nurse Case Management to Improve Linkage to Hepatitis C Care and Treatment Initiation in HIV Co-infection: A Randomized Controlled Trial[NCT02707991]68 participants (Actual)Interventional2016-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants Linked to Care

"This will be assessed based on the number of participants who attend an appointment at the Viral Hepatitis Clinic within 60 days of enrolling in the study. A participant is considered linked to care if he/she attends an appointment at the clinic. A participant is considered not linked to care if he/she does not attend an appointment at the clinic. Whether a participant linked to care will be determined by looking at the medical record, where all attended appointments are documented. If no attended appointment is documented, this will be considered non-attendance/not linked to care." (NCT02707991)
Timeframe: 60 days

InterventionParticipants (Count of Participants)
Enhanced Usual Care8
Nurse Case Management16

Time to Hepatitis C Treatment Initiation

Number of days from study enrollment to receipt of the first dose of hepatitis C treatment (NCT02707991)
Timeframe: 6 months

Interventiondays (Mean)
Enhanced Usual Care103
Nurse Case Management79.3

Trials

4 trials available for methadone and Hepatitis A

ArticleYear
A randomized trial of a hepatitis care coordination model in methadone maintenance treatment.
    American journal of public health, 2013, Volume: 103, Issue:10

    Topics: Adult; Confidence Intervals; Female; Hepatitis A; Hepatitis B; Humans; Male; Methadone; Middle Aged;

2013
Education and counseling in the methadone treatment setting improves knowledge of viral hepatitis.
    Journal of substance abuse treatment, 2014, Volume: 46, Issue:4

    Topics: Adult; Counseling; Female; Follow-Up Studies; Health Knowledge, Attitudes, Practice; Hepatitis A; He

2014
Viral hepatitis among drug users in methadone maintenance: associated factors, vaccination outcomes, and interventions.
    Journal of addictive diseases, 2014, Volume: 33, Issue:4

    Topics: Adult; Aged; Female; Hepatitis A; Hepatitis B; Hepatitis C; Humans; Male; Methadone; Middle Aged; Ne

2014
Predictors of hepatitis knowledge improvement among methadone maintained clients enrolled in a hepatitis intervention program.
    Journal of community health, 2010, Volume: 35, Issue:4

    Topics: Female; Follow-Up Studies; Health Knowledge, Attitudes, Practice; Health Promotion; Hepatitis A; Hep

2010

Other Studies

6 other studies available for methadone and Hepatitis A

ArticleYear
[Prevalence of serological markers of viral hepatitis B and hepatitis C in drug-dependent individuals treated at the Drop Methadone Center in Prague].
    Casopis lekaru ceskych, 2003, Volume: 142, Issue:4

    Topics: Adult; Czech Republic; Female; Hepatitis A; Hepatitis B; Hepatitis C; Humans; Male; Methadone; Middl

2003
Hepatitis C, B, D, and A: contrasting features and liver function abnormalities in heroin addicts.
    Journal of addictive diseases, 2001, Volume: 20, Issue:1

    Topics: Carrier State; Hepatitis A; Hepatitis B; Hepatitis C; Hepatitis D; Heroin Dependence; Humans; Liver

2001
The spectrum and causes of liver diseases in narcotic addicts.
    The American journal of gastroenterology, 1977, Volume: 67, Issue:4

    Topics: Acute Disease; Alcoholism; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Chronic Disease;

1977
Incidence of hepatitis-associated antigen among patients in a methadone clinic.
    Southern medical journal, 1973, Volume: 66, Issue:3

    Topics: Adult; Female; Hepatitis A; Hepatitis B Antigens; Humans; Male; Methadone; Middle Aged; Substance-Re

1973
Hepatitis B antigen and antibody in former heroin addicts on methadone maintenance: correlation with clinical and histological findings.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 1

    Topics: Alcoholism; Antibodies; Antibody Specificity; Biopsy; Hepatitis A; Hepatitis B Antigens; Heroin Depe

1973
Misuse of heroin and methadone in the City of Oxford.
    The British journal of psychiatry : the journal of mental science, 1972, Volume: 120, Issue:558

    Topics: Adolescent; Adult; Crime; England; Female; Hepatitis A; Heroin; Hospitalization; Humans; Injections,

1972